Peter Barnes
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British pulmonary scientist and clinician
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Why Is Peter Barnes Influential?
(Suggest an Edit or Addition)According to Wikipedia, Sir Peter John Barnes, FRCP, FCCP, FMedSci, FRS is a British respiratory scientist and clinician, a specialist in the mechanisms and treatment of asthma and chronic obstructive pulmonary disease . He was Margaret Turner-Warwick Professor of Thoracic Medicine at the National Heart & Lung Institute, previous head of respiratory medicine at Imperial College and honorary consultant physician at the Royal Brompton Hospital London. He is one of the most highly cited scientists in the world
Peter Barnes 's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. (2007) (12905)
- Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. (1997) (4674)
- Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report. GOLD Executive Summary. (2017) (3143)
- Global strategy for asthma management and prevention: GINA executive summary (2008) (2982)
- Chronic obstructive pulmonary disease. (2000) (2258)
- Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsìveness, and the late asthmatic response (2000) (1869)
- Systemic manifestations and comorbidities of COPD (2009) (1561)
- Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group. (1997) (1536)
- Anti-inflammatory actions of glucocorticoids: molecular mechanisms. (1998) (1505)
- Increased nitric oxide in exhaled air of asthmatic patients (1994) (1480)
- Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma. (1996) (1458)
- Immunology of asthma and chronic obstructive pulmonary disease (2008) (1349)
- Exhaled breath condensate: methodological recommendations and unresolved questions (2005) (1229)
- Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease: the GOLD science committee report 2019 (2019) (1127)
- Decreased histone deacetylase activity in chronic obstructive pulmonary disease. (2005) (972)
- Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. (2007) (946)
- Glucocorticoid resistance in inflammatory diseases (2009) (909)
- The cytokine network in asthma and chronic obstructive pulmonary disease. (2008) (890)
- Neutrophilic inflammation in severe persistent asthma. (1999) (880)
- Inflammatory mechanisms in patients with chronic obstructive pulmonary disease. (2016) (858)
- Exhaled markers of pulmonary disease. (2001) (841)
- Inflammatory mediators of asthma: an update. (1998) (799)
- Exacerbations of chronic obstructive pulmonary disease (2007) (797)
- Glucocorticoid Receptor Recruitment of Histone Deacetylase 2 Inhibits Interleukin-1β-Induced Histone H4 Acetylation on Lysines 8 and 12 (2000) (746)
- Isoprostanes: markers and mediators of oxidative stress (2004) (730)
- Efficacy and safety of inhaled corticosteroids. New developments. (1998) (725)
- Anti-inflammatory actions of steroids: molecular mechanisms. (1993) (723)
- Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma. (1998) (716)
- Chronic obstructive pulmonary disease in non-smokers (2009) (716)
- Mediators of Chronic Obstructive Pulmonary Disease (2004) (700)
- Exhaled and nasal nitric oxide measurements: recommendations. The European Respiratory Society Task Force. (1997) (699)
- How corticosteroids control inflammation: Quintiles Prize Lecture 2005 (2006) (696)
- Low dose inhaled budesonide and formoterol in mild persistent asthma: the OPTIMA randomized trial. (2001) (694)
- Inhaled glucocorticoids for asthma. (1995) (628)
- Neural control of human airways in health and disease. (2015) (623)
- Histone deacetylase 2–mediated deacetylation of the glucocorticoid receptor enables NF-κB suppression (2006) (622)
- Inhaled glucocorticoids decrease nitric oxide in exhaled air of asthmatic patients. (1996) (595)
- Effects of inhaled and oral glucocorticoids on inflammatory indices in asthma and COPD. (1997) (591)
- Sex and gender: modifiers of health, disease, and medicine (2020) (589)
- Effect of incorrect use of dry powder inhalers on management of patients with asthma and COPD. (2008) (574)
- Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease. (2013) (571)
- Exhaled 8-isoprostane as an in vivo biomarker of lung oxidative stress in patients with COPD and healthy smokers. (2000) (568)
- Oxidative stress in COPD. (2013) (559)
- In situ hybridization. (1997) (557)
- Increased 8-isoprostane, a marker of oxidative stress, in exhaled condensate of asthma patients. (1999) (556)
- Histone acetylation and deacetylation: importance in inflammatory lung diseases (2005) (549)
- Reactive oxygen species and airway inflammation. (1990) (530)
- Nitric oxide and asthmatic inflammation. (1995) (521)
- Nuclear factor-kappa B. (1997) (516)
- Regional lung deposition and bronchodilator response as a function of beta2-agonist particle size. (2005) (508)
- A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression (2002) (496)
- Efficacy and Safety of Inhaled Corticosteroids in Asthma (1993) (487)
- Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages. (2001) (481)
- Release and activity of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 by alveolar macrophages from patients with chronic obstructive pulmonary disease. (2002) (474)
- Theophylline Restores Histone Deacetylase Activity and Steroid Responses in COPD Macrophages (2004) (473)
- New concepts in the pathogenesis of bronchial hyperresponsiveness and asthma. (1989) (472)
- Acute and chronic effects of cigarette smoking on exhaled nitric oxide. (1995) (472)
- Glucocorticosteroids: current and future directions (2011) (471)
- Increased formation of the potent oxidant peroxynitrite in the airways of asthmatic patients is associated with induction of nitric oxide synthase: effect of inhaled glucocorticoid (1998) (460)
- Beta-adrenergic receptors and their regulation. (1995) (459)
- Activation and localization of transcription factor, nuclear factor-kappaB, in asthma. (1998) (453)
- A new approach to the treatment of asthma. (1989) (452)
- Nitric oxide and lung disease. (1993) (446)
- Cytokines in asthma (1999) (438)
- Neuropeptides in the respiratory tract. Part I. (1991) (436)
- Theophylline: new perspectives for an old drug. (2003) (430)
- A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma. (2009) (424)
- Effect of high dose inhaled steroid on cells, cytokines, and proteases in induced sputum in chronic obstructive pulmonary disease. (1999) (422)
- Changes in sputum eosinophils predict loss of asthma control. (2000) (422)
- Granulocyte activation markers in induced sputum: comparison between chronic obstructive pulmonary disease, asthma, and normal subjects. (1997) (420)
- Increased nitric oxide in exhaled air of normal human subjects with upper respiratory tract infections. (1995) (415)
- p38 Mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: role in steroid-insensitive asthma. (2002) (411)
- Nocturnal asthma and changes in circulating epinephrine, histamine, and cortisol. (1980) (411)
- Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic response (2000) (409)
- Inflammatory mediators and asthma. (1988) (405)
- COPD as a disease of accelerated lung aging(a). (2009) (400)
- Nitric oxide is the endogenous neurotransmitter of bronchodilator nerves in humans. (1992) (394)
- Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase (2004) (390)
- Corticosteroid effects on cell signalling (2006) (386)
- Evidence for Involvement of NF-κB in the Transcriptional Control of COX-2 Gene Expression by IL-1β ☆ (1997) (385)
- A European Respiratory Society technical standard: exhaled biomarkers in lung disease (2017) (383)
- Tumor necrosis factor-alpha increases airway responsiveness and sputum neutrophilia in normal human subjects. (1995) (377)
- Exhaled nitric oxide in pulmonary diseases: a comprehensive review. (2010) (377)
- Inhaled Combined Budesonide–Formoterol as Needed in Mild Asthma (2018) (373)
- Cellular and molecular mechanisms of chronic obstructive pulmonary disease. (2014) (367)
- Oxidative stress reduces histone deacetylase 2 activity and enhances IL-8 gene expression: role of tyrosine nitration. (2004) (365)
- New anti-inflammatory targets for chronic obstructive pulmonary disease (2013) (361)
- Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary (2017) (360)
- Exacerbations of asthma: a descriptive study of 425 severe exacerbations. The FACET International Study Group. (1999) (359)
- Increased levels of the chemokines GROα and MCP-1 in sputum samples from patients with COPD (2002) (358)
- Regulation of pulmonary vascular tone. (1995) (357)
- Measurement of exhaled nitric oxide in children, 2001 (2002) (357)
- Inhaled corticosteroids increase interleukin-10 but reduce macrophage inflammatory protein-1alpha, granulocyte-macrophage colony-stimulating factor, and interferon-gamma release from alveolar macrophages in asthma. (1998) (349)
- Expression of inducible nitric oxide in human lung epithelial cells. (1994) (349)
- Positional cloning of a novel gene influencing asthma from Chromosome 2q14 (2003) (342)
- Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms. (2004) (341)
- How Do Corticosteroids Work in Asthma? (2003) (336)
- Transcription factors and asthma. (1998) (336)
- The cytokine network in chronic obstructive pulmonary disease. (2009) (335)
- Impaired inhibition by dexamethasone of cytokine release by alveolar macrophages from patients with chronic obstructive pulmonary disease. (2003) (335)
- Mechanisms in COPD: differences from asthma. (2000) (332)
- Induction of cyclo‐oxygenase‐2 by cytokines in human pulmonary epithelial cells: regulation by dexamethasone (1994) (331)
- Lung delivery studies using siRNA conjugated to TAT(48-60) and penetratin reveal peptide induced reduction in gene expression and induction of innate immunity. (2007) (330)
- Tolerance to the Nonbronchodilator Effects of Inhaled β2-Agonists in Asthma (1992) (330)
- Allergen-induced late asthmatic reactions are associated with elevation of exhaled nitric oxide. (1995) (326)
- Elevated levels of exhaled nitric oxide in bronchiectasis. (1995) (325)
- Alveolar Macrophages as Orchestrators of COPD (2004) (322)
- Exhaled nitric oxide in chronic obstructive pulmonary disease. (1998) (318)
- Autoradiographic visualization of beta-adrenoceptor subtypes in human lung. (1985) (317)
- Reproducibility of exhaled nitric oxide measurements in healthy and asthmatic adults and children (2003) (315)
- Defective macrophage phagocytosis of bacteria in COPD (2009) (315)
- As‐Needed Budesonide–Formoterol versus Maintenance Budesonide in Mild Asthma (2018) (310)
- Targeting phosphoinositide-3-kinase-delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease. (2010) (309)
- Raised levels of exhaled carbon monoxide are associated with an increased expression of heme oxygenase-1 in airway macrophages in asthma: a new marker of oxidative stress (1998) (308)
- Chronic obstructive pulmonary disease (2012) (302)
- Expression and activity of histone deacetylases in human asthmatic airways. (2002) (302)
- Oxidative stress–induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease (2015) (299)
- Neurogenic inflammation in the airways. (2001) (297)
- Increased exhaled nitric oxide in asthma is mainly derived from the lower respiratory tract. (1996) (296)
- Importance of inhaler devices in the management of airway disease. (2008) (294)
- Pulmonary biomarkers in chronic obstructive pulmonary disease. (2006) (294)
- 8-Isoprostane, a marker of oxidative stress, is increased in exhaled breath condensate of patients with obstructive sleep apnea after night and is reduced by continuous positive airway pressure therapy. (2003) (293)
- Haplotype associated with low interleukin-10 production in patients with severe asthma (1998) (292)
- Airway inflammation after controlled exposure to diesel exhaust particulates. (2000) (290)
- Role of HDAC2 in the pathophysiology of COPD. (2009) (289)
- Exhaled leukotrienes and prostaglandins in COPD (2003) (287)
- Increased leukotriene B4 and 8-isoprostane in exhaled breath condensate of patients with exacerbations of COPD (2003) (287)
- Exhaled ethane, a marker of lipid peroxidation, is elevated in chronic obstructive pulmonary disease. (2000) (286)
- EFFECT OF A GINKGOLIDE MIXTURE (BN 52063) IN ANTAGONISING SKIN AND PLATELET RESPONSES TO PLATELET ACTIVATING FACTOR IN MAN (1987) (285)
- Systematic assessment of difficult-to-treat asthma (2003) (283)
- Mechanisms and resistance in glucocorticoid control of inflammation (2010) (282)
- The effect of airway epithelium on smooth muscle contractility in bovine trachea (1985) (281)
- New concepts in chronic obstructive pulmonary disease. (2003) (280)
- Cellular and molecular mechanisms of asthma and COPD. (2017) (280)
- Relative corticosteroid insensitivity of peripheral blood mononuclear cells in severe asthma. (2006) (279)
- Biomarkers of some pulmonary diseases in exhaled breath (2002) (278)
- Corticosteroids: the drugs to beat. (2006) (277)
- Alveolar macrophage-mediated elastolysis: roles of matrix metalloproteinases, cysteine, and serine proteases. (2002) (276)
- The costs of asthma. (1996) (275)
- Effect of differing doses of inhaled budesonide on markers of airway inflammation in patients with mild asthma (1999) (275)
- Increased production of the potent oxidant peroxynitrite in the lungs of patients with idiopathic pulmonary fibrosis. (1997) (274)
- Exhaled nitric oxide: a new lung function test. (1996) (273)
- The need to improve inhalation technique in Europe: a report from the Aerosol Drug Management Improvement Team. (2006) (272)
- Bradykinin–evoked sensitization of airway sensory nerves: A mechanism for ACE–inhibitor cough (1996) (271)
- Nitric oxide and airway disease. (1995) (268)
- Human airway smooth muscle cells express and release RANTES in response to T helper 1 cytokines: regulation by T helper 2 cytokines and corticosteroids. (1997) (265)
- Effect of a nitric oxide synthase inhibitor and a glucocorticosteroid on exhaled nitric oxide. (1995) (265)
- Increased nitrotyrosine in exhaled breath condensate of patients with asthma. (2000) (264)
- Increased 8-isoprostane and interleukin-6 in breath condensate of obstructive sleep apnea patients. (2002) (263)
- Protective effects of a glucocorticoid on downregulation of pulmonary beta 2-adrenergic receptors in vivo. (1995) (263)
- Combined use of exhaled hydrogen peroxide and nitric oxide in monitoring asthma. (1998) (263)
- Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared with non-severe asthma (2008) (263)
- 8-Isoprostane as a biomarker of oxidative stress in interstitial lung diseases. (1998) (260)
- Balance of matrix metalloprotease-9 and tissue inhibitor of metalloprotease-1 from alveolar macrophages in cigarette smokers. Regulation by interleukin-10. (2000) (260)
- A comparison of low-dose inhaled budesonide plus theophylline and high-dose inhaled budesonide for moderate asthma. (1997) (260)
- Changes in the dose of inhaled steroid affect exhaled nitric oxide levels in asthmatic patients. (1996) (259)
- Immunomodulation by theophylline in asthma. Demonstration by withdrawal of therapy. (1995) (257)
- Abnormal glucocorticoid receptor-activator protein 1 interaction in steroid-resistant asthma (1995) (254)
- Oxidative Stress Induces NFκB DNA Binding and Inducible NOS mRNA in Human Epithelial Cells (1994) (253)
- Neutrophil chemotactic activity of sputum from patients with COPD: role of interleukin 8 and leukotriene B4. (2003) (252)
- Accelerated ageing of the lung in COPD: new concepts (2015) (250)
- Targeting cytokines to treat asthma and chronic obstructive pulmonary disease (2018) (248)
- Bradykinin-induced bronchoconstriction in humans. Mode of action. (1987) (247)
- Histone acetylase and deacetylase activity in alveolar macrophages and blood mononocytes in asthma. (2004) (247)
- The Effects of a Monoclonal Antibody Directed against Tumor Necrosis Factor-α in Asthma (2006) (247)
- Inhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2, open-label, randomised controlled trial (2021) (246)
- COPD: current therapeutic interventions and future approaches (2005) (246)
- Clinical aspects of exhaled nitric oxide. (2000) (244)
- Theophylline in the management of asthma: time for reappraisal? (1994) (242)
- Therapeutic strategies for allergic diseases (1999) (240)
- Dose-dependent onset and cessation of action of inhaled budesonide on exhaled nitric oxide and symptoms in mild asthma (2002) (240)
- Effect of inhaled budesonide on lung function and airway inflammation. Assessment by various inflammatory markers in mild asthma. (1999) (240)
- COPD as a disease of accelerated lung aging. (2009) (239)
- Autoradiographic visualization of muscarinic receptor subtypes in human and guinea pig lung. (1990) (237)
- Bronchoconstrictor response to inhaled capsaicin in humans. (1985) (237)
- Molecular mechanisms of corticosteroid resistance. (2008) (236)
- Exhaled leukotrienes and prostaglandins in asthma. (2002) (234)
- Identification of cyclic AMP phosphodiesterases 3, 4 and 7 in human CD4+ and CD8+ T‐lymphocytes: role in regulating proliferation and the biosynthesis of interleukin‐2 (1996) (233)
- Autonomic regulation of the airways. (1984) (232)
- Insights into oxidative stress: the isoprostanes. (2007) (231)
- Modulation of neurotransmission in airways. (1992) (231)
- Efficacy of inhaled corticosteroids in asthma. (1998) (229)
- Exhaled biomarkers. (2006) (223)
- Rhinovirus infection induces degradation of antimicrobial peptides and secondary bacterial infection in chronic obstructive pulmonary disease. (2012) (223)
- Platelet-activating factor as a mediator of allergic disease. (1988) (223)
- Chronic idiopathic cough: a discrete clinical entity? (2005) (222)
- Chronic Obstructive Pulmonary Disease and Lung Cancer: New Molecular Insights (2011) (222)
- Inhibition of PI3Kdelta restores glucocorticoid function in smoking-induced airway inflammation in mice. (2009) (219)
- Nuclear localisation of p65 in sputum macrophages but not in sputum neutrophils during COPD exacerbations. (2003) (218)
- Glucocorticoid receptor nuclear translocation in airway cells after inhaled combination therapy. (2005) (217)
- Exhaled 8-isoprostane as a new non-invasive biomarker of oxidative stress in cystic fibrosis (2000) (216)
- The pharmacological properties of tiotropium. (2000) (214)
- Increased leukotrienes in exhaled breath condensate in childhood asthma. (2002) (214)
- Increased nitrosothiols in exhaled breath condensate in inflammatory airway diseases. (2001) (213)
- Is exposure to biomass smoke the biggest risk factor for COPD globally? (2010) (213)
- Glucocorticosteroids increase beta 2-adrenergic receptor transcription in human lung. (1995) (211)
- Inhibition by red wine extract, resveratrol, of cytokine release by alveolar macrophages in COPD (2003) (211)
- Elevation of exhaled ethane concentration in asthma. (2000) (211)
- Repression of Cyclooxygenase-2 and Prostaglandin E2Release by Dexamethasone Occurs by Transcriptional and Post-transcriptional Mechanisms Involving Loss of Polyadenylated mRNA* (1998) (210)
- Capsazepine inhibits cough induced by capsaicin and citric acid but not by hypertonic saline in guinea pigs. (1995) (209)
- Exhaled nitric oxide from lung periphery is increased in COPD (2005) (209)
- Prejunctional inhibitory muscarinic receptors on cholinergic nerves in human and guinea pig airways. (1988) (208)
- Defective glucocorticoid receptor nuclear translocation and altered histone acetylation patterns in glucocorticoid-resistant patients. (2004) (206)
- New therapies for asthma: is there any progress? (2010) (205)
- Cytokines as mediators of chronic asthma. (1994) (204)
- NF-kB: a pivotal role in asthma and a new target for therapy (1997) (203)
- Stimulation of degranulation from human eosinophils by platelet-activating factor. (1989) (203)
- A muscarinic agonist inhibits reflex bronchoconstriction in normal but not in asthmatic subjects. (1989) (202)
- Th2 cytokines and asthma: an introduction (2001) (198)
- New drugs for asthma (1992) (198)
- Modulation of neurogenic inflammation: novel approaches to inflammatory disease. (1990) (197)
- Chronic Obstructive Pulmonary Disease: Effects beyond the Lungs (2010) (197)
- Effect of platelet-activating factor on airway vascular permeability: possible mechanisms. (1987) (197)
- Pathophysiology of asthma. (2003) (195)
- Increased exhaled cysteinyl-leukotrienes and 8-isoprostane in aspirin-induced asthma. (2002) (194)
- Nasal nitric oxide is increased in patients with asthma and allergic rhinitis and may be modulated by nasal glucocorticoids. (1997) (193)
- Asthma : basic mechanisms and clinical management (1988) (192)
- New molecular targets for the treatment of neutrophilic diseases. (2007) (192)
- Prospects for new drugs for chronic obstructive pulmonary disease (2004) (192)
- Diagnostic performance of an electronic nose, fractional exhaled nitric oxide, and lung function testing in asthma. (2010) (192)
- An in vitro study of the properties of single vagal afferents innervating guinea‐pig airways. (1993) (190)
- Analysis of expired air for oxidation products. (2002) (189)
- Effect of a 5-lipoxygenase inhibitor on leukotriene generation and airway responses after allergen challenge in asthmatic patients. (1991) (189)
- Matrix metalloproteinase-9 expression in asthma: effect of asthma severity, allergen challenge, and inhaled corticosteroids. (2002) (189)
- IκBα Degradation and Nuclear Factor-κB DNA Binding Are Insufficient for Interleukin-1β and Tumor Necrosis Factor-α-induced κB-dependent Transcription* (1998) (189)
- Expression and release of interleukin-8 by human airway smooth muscle cells: inhibition by Th-2 cytokines and corticosteroids. (1998) (186)
- Treatment of airway mucus hypersecretion (2006) (185)
- Induction of cyclo‐oxygenase‐2 by cytokines in human cultured airway smooth muscle cells: novel inflammatory role of this cell type (1997) (184)
- Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress (2011) (183)
- Analysis of exhaled breath condensate for monitoring airway inflammation. (2002) (181)
- Plasma exudation. Correlation between Evans blue dye and radiolabeled albumin in guinea pig airways in vivo. (1989) (181)
- Effect of a leukotriene B4 receptor antagonist, LY293111, on allergen induced responses in asthma. (1996) (180)
- TGFβ1 allele association with asthma severity (2001) (180)
- Specific CXC but not CC chemokines cause elevated monocyte migration in COPD: a role for CXCR2 (2004) (180)
- Differential IkappaB kinase activation and IkappaBalpha degradation by interleukin-1beta and tumor necrosis factor-alpha in human U937 monocytic cells. Evidence for additional regulatory steps in kappaB-dependent transcription. (1999) (177)
- Exhaled carbon monoxide and nitric oxide in COPD. (2001) (176)
- Cellular Senescence as a Mechanism and Target in Chronic Lung Diseases. (2019) (175)
- Delayed eosinophil apoptosis in asthma. (2000) (174)
- Elevated expression of endothelin-1 and endothelin-converting enzyme-1 in idiopathic pulmonary fibrosis: possible involvement of proinflammatory cytokines. (1997) (173)
- Severe asthma: advances in current management and future therapy. (2012) (171)
- Increased pulmonary α-adrenergic and reduced β-adrenergic receptors in experimental asthma (1980) (171)
- Endogenous nitric oxide is decreased in asthmatic patients by an inhibitor of inducible nitric oxide synthase. (1996) (170)
- Defective phagocytosis in airways disease. (2012) (169)
- Distribution of receptor targets in the lung. (2004) (169)
- Glucocorticoids: effects on gene transcription. (2004) (167)
- High levels of interleukin-6 in the exhaled breath condensate of patients with COPD. (2003) (166)
- Evidence for involvement of NF-kappaB in the transcriptional control of COX-2 gene expression by IL-1beta. (1997) (166)
- VIP and PHM and their role in nonadrenergic inhibitory responses in isolated human airways. (1986) (165)
- Maternally imprinted microRNAs are differentially expressed during mouse and human lung development (2007) (165)
- Increased interleukin-4 and decreased interferon-gamma in exhaled breath condensate of children with asthma. (2002) (165)
- Glucocorticoid receptor localization in normal and asthmatic lung. (1996) (165)
- Treatment effects of low-dose theophylline combined with an inhaled corticosteroid in COPD. (2010) (164)
- SEVERE PREMENSTRUAL EXACERBATIONS OF ASTHMA: EFFECT OF INTRAMUSCULAR PROGESTERONE (1988) (163)
- Increased levels of exhaled carbon monoxide in bronchiectasis: a new marker of oxidative stress (1998) (163)
- Elevated concentrations of exhaled hydrogen peroxide in asthmatic patients. (2001) (163)
- Expression of RANTES mRNA and protein in airways of patients with mild asthma. (1996) (163)
- L-arginine increases exhaled nitric oxide in normal human subjects. (1995) (163)
- Increase in exhaled nitric oxide levels in patients with difficult asthma and correlation with symptoms and disease severity despite treatment with oral and inhaled corticosteroids (1998) (162)
- Effect of theophylline on induced sputum inflammatory indices and neutrophil chemotaxis in chronic obstructive pulmonary disease. (2002) (162)
- Oxidative stress-induced antibodies to carbonyl-modified protein correlate with severity of chronic obstructive pulmonary disease. (2012) (161)
- The Electronic Nose in Respiratory Medicine (2012) (160)
- Senescence in COPD and Its Comorbidities. (2017) (160)
- Reduced histone deacetylase in COPD: clinical implications. (2006) (159)
- Inhibition of macrophage inflammatory protein-1 alpha expression by IL-10. Differential sensitivities in human blood monocytes and alveolar macrophages. (1995) (159)
- Increased tachykinin receptor gene expression in asthmatic lung and its modulation by steroids. (1993) (158)
- Characterization of allergen-induced bronchial hyperresponsiveness and airway inflammation in actively sensitized brown-Norway rats. (1991) (157)
- Modulation of cholinergic neural bronchoconstriction by endogenous nitric oxide and vasoactive intestinal peptide in human airways in vitro. (1993) (157)
- Cytokine induction of cytosolic phospholipase A2 and cyclooxygenase-2 mRNA is suppressed by glucocorticoids in human epithelial cells. (1996) (157)
- Air pollution and asthma. (1994) (157)
- Nasal nitric oxide measurements for the screening of primary ciliary dyskinesia (2003) (156)
- Inhaled corticosteroids are not beneficial in chronic obstructive pulmonary disease. (2000) (155)
- CXCR3 and CCR5 chemokines in induced sputum from patients with COPD. (2008) (155)
- Integrated care pathways for airway diseases (AIRWAYS-ICPs) (2014) (155)
- Increased p21(CIP1/WAF1) and B cell lymphoma leukemia-x(L) expression and reduced apoptosis in alveolar macrophages from smokers. (2002) (155)
- Differences in binding of glucocorticoid receptor to DNA in steroid-resistant asthma. (1995) (154)
- Nitration of distinct tyrosine residues causes inactivation of histone deacetylase 2. (2009) (154)
- Inhaled Corticosteroids (2010) (153)
- Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a Selective Inhibitor of Phosphodiesterase 7: In Vitro Studies in Human Monocytes, Lung Macrophages, and CD8+ T-Lymphocytes (2004) (153)
- Glucocorticoid resistance in asthma. (1995) (152)
- New treatments for copd (2002) (152)
- Regulation of Th2 Cytokine Genes by p38 MAPK-Mediated Phosphorylation of GATA-31 (2007) (151)
- SINGLE-DOSE SLOW-RELEASE AMINOPHYLLINE AT NIGHT PREVENTS NOCTURNAL ASTHMA (1982) (151)
- Unbalanced oxidant-induced DNA damage and repair in COPD: a link towards lung cancer (2011) (151)
- Increased leukotriene B4 and interleukin-6 in exhaled breath condensate in cystic fibrosis. (2003) (151)
- Therapeutic approaches to asthma-chronic obstructive pulmonary disease overlap syndromes. (2015) (150)
- A dose-dependent effect of the novel inhaled corticosteroid ciclesonide on airway responsiveness to adenosine-5'-monophosphate in asthmatic patients. (1999) (150)
- Epigenetics and airways disease (2006) (150)
- Mechanisms of action of glucocorticoids in asthma. (1996) (149)
- Suppression of lipopolysaccharide-induced tumor necrosis factor-alpha generation from human peripheral blood monocytes by inhibitors of phosphodiesterase 4: interaction with stimulants of adenylyl cyclase. (1995) (149)
- Sputum matrix metalloproteases: comparison between chronic obstructive pulmonary disease and asthma. (2005) (149)
- Cellular profiles in asthmatic airways: a comparison of induced sputum, bronchial washings, and bronchoalveolar lavage fluid. (1997) (148)
- p65-activated Histone Acetyltransferase Activity Is Repressed by Glucocorticoids (2001) (148)
- Measurement of bronchial and alveolar nitric oxide production in normal children and children with asthma. (2006) (147)
- Muscarinic receptor subtypes in airways. (1993) (147)
- NF-κB and Activator Protein 1 Response Elements and the Role of Histone Modifications in IL-1β-Induced TGF-β1 Gene Transcription1 (2006) (147)
- Nitric oxide as an endogenous modulator of cholinergic neurotransmission in guinea-pig airways. (1991) (147)
- Effect of corticosteroids on airway hyperresponsiveness. (1990) (147)
- Scientific rationale for using a single inhaler for asthma control (2007) (145)
- Chronic Obstructive Pulmonary Disease: A Growing but Neglected Global Epidemic (2007) (145)
- Elevated levels of expired breath hydrogen peroxide in bronchiectasis. (1998) (145)
- Corticosteroid-resistant bronchial asthma is associated with increased c-fos expression in monocytes and T lymphocytes. (1998) (145)
- Autoradiographic localization of autonomic receptors in airway smooth muscle. Marked differences between large and small airways. (1983) (145)
- Quantifying proliferation of cultured human and rabbit airway smooth muscle cells in response to serum and platelet-derived growth factor. (1992) (145)
- Addition of leukotriene antagonists to therapy in chronic persistent asthma: a randomised double-blind placebo-controlled trial (2001) (144)
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- Prostaglandin D2 potentiates airway responsiveness to histamine and methacholine. (1986) (117)
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- Greater effect of inhaled budesonide on adenosine 5'-monophosphate-induced than on sodium-metabisulfite-induced bronchoconstriction in asthma. (1992) (116)
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- Update on asthma. (2003) (116)
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- Tiotropium bromide (Ba 679 BR), a novel long-acting muscarinic antagonist for the treatment of obstructive airways disease. (1995) (115)
- Alternative mechanisms for tiotropium. (2009) (115)
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- Low-dose theophylline reduces eosinophilic inflammation but not exhaled nitric oxide in mild asthma. (2001) (115)
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- Histone deacetylase-2 and airway disease (2009) (114)
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- Tumour Necrosis Factor-α Regulates Human Eosinophil Apoptosis via Ligation of TNF-Receptor 1 and Balance between NF-κB and AP-1 (2014) (46)
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- Decreased PTEN amplifies PI3K signaling and enhances pro-inflammatory cytokine release in COPD (2016) (0)
- News Review: Lipid Technology 4/2007 (2007) (0)
- Fluticasone Furoate, A Novel Enhanced-affinity Inhaled Corticosteroid, Has A Longer Duration Of Anti-inflammatory Action Than Fluticasone Propionate And Budesonide (2010) (0)
- LSC Abstract – GM-CSF drives human lung tissue macrophages towards a more pro-inflammatory phenotype (2016) (0)
- Book Review: Bronchial Hyperreactivity (1983) (0)
- Effects of phosphoinositide-3-kinase inhibitors on steroid-insensitive airway inflammation in poly(I:C) and allergen challenged mice (2016) (0)
- Comparison of budesonide and fluticasone propionate on COPD macrophage phagocytosis and killing of bacteria (2014) (0)
- Sensory and Inflammatory Peptide Receptors in Airways (2020) (0)
- TRPV 1 in the airways (0)
- News Review: Lipid Technology 6/2007 (2007) (0)
- Monocyte sub-populations do not reflect differences in COPD macrophage phenotype (2015) (0)
- COPD : burden of disease , imaging and management (2011) (0)
- Impaired protein tyrosine phosphatase PTPRR reduces response to corticosteroid in mononuclear cells (2013) (0)
- Gene theraphy in inflammatory diseases (edited by C.H. Evans and P.D. Robbins) (2001) (0)
- The Pathogenesis and Treatment of Asthma as an Inflammatory Disease (2000) (0)
- Differential autoradiographic localization of leukotriene binding sites in guinea pig airways. (1987) (0)
- Mast cell effector mechanisms. Discussion (1996) (0)
- Colony stimulating factors cannot correct defective phagocytosis in COPD lung tissue macrophages (2016) (0)
- Recent advances inasthma (1992) (0)
- Allergic Respiratory Inflammation and Remodeling (2016) (0)
- Methylxanthines and Phosphodiesterase in Hibitors (2008) (0)
- Concordance between airway inflammation and health status in COPD patients with bacterial colonisation (2013) (0)
- eosinophil but not neutrophil apoptosis Caspase-catalyzed cleavage and activation of Mst1 correlates with (2013) (0)
- Exhaled nitric oxide in pulmonary diseases: a comprehensive review | NOVA. The University of Newcastle's Digital Repository (2010) (0)
- Autonomic receptors (1991) (0)
- Chapter 40 – Drugs (2009) (0)
- Other Mediators of Airway Disease (2002) (0)
- Modulation de l'histone deacetylase (2001) (0)
- Novel Anti-inflammatory Therapies (2004) (0)
- Late-breaking abstract: HRCT comparisons of tobacco smoking (TS-COPD) and biomass smoke induced COPD (BS-COPD) phenotypes from an Indian rural setting (2014) (0)
- Nasal Challenge with Hypertonic Saline (HTS) and Assessment of Neural Reflex Activation (NRA). (2009) (0)
- Location of beta(1) & beta(2)-adrenoreceptors in the developing porcine lung (1999) (0)
- Microtubule Instability in COPD Leads to Defective Macrophage Phagocytosis of Bacteria. (2009) (0)
- About the Authors (2003) (0)
- 896 Exhaled breath profile of inflammatory and oxidative markers in lung diseases (2000) (0)
- Increased Deposition Of Activated Complement In Peripheral Lung Vessels Of Smokers (2010) (0)
- Pathophysiology and clinical presentations of cough. Discussion (1996) (0)
- Nocturnal asthma. (1987) (0)
- [Pathogenetic importance of eosinophilic granulocytes. II. Hypereosinophilic diseases]. (1988) (0)
- Nitrosative stress in ACO. (2019) (0)
- PHOSPHODIESTERASE INHIBITORS: WILL THEY REPLACE THEOPHYLLINE? (1993) (0)
- Contributors (2006) (0)
- Oxidative stress-induced corticosteroid insensitivity is reversed by formoterol via inhibition of PI3K signalling in peripheral blood mononuclear cells from patients with COPD and severe asthma (2011) (0)
- Histamine levels following adenosine monophosphate challenge (2005) (0)
- Substance P Enhances the Transient Ventilatory Hypoxic Response in Man (1985) (0)
- ESAT-6 from Mycobacterium tuberculosis inhibits T cell IFN-{gamma} production through p38 MAP kinase pathway (2011) (0)
- Bromodomain and extra-terminal (BET) proteins regulate antioxidant gene expression (2013) (0)
- DJ-1 and its anti-oxidative stress response regulates the expression of sirtuin-1 in COPD epithelial cells (2017) (0)
- 169 Protein kinase C isoenzymes in airway smooth muscle (1997) (0)
- Induction Of Wnt4 And Its Role In Inflammation In COPD (2012) (0)
- DECREASED MACROPHAGE FUNCTION IN COPD (2009) (0)
- Inhibition of dynein motors improves macrophage phagocytosis in COPD (2017) (0)
- Epithelial Cell and Lung Cancer: Introduction (2010) (0)
- C0mposicipon pharmaceutical comprising resveratrol to treat inflammatory disorders repiratorios. (2001) (0)
- Failure to thrive (2008) (0)
- p38 MAPK inhibitors in COPD (2012) (0)
- Effect of JQ-1 on monocyte-derived macrophage (MDM) phagocytosis of bacteria and cytokine release (2013) (0)
- Effects Of PF-956980, A Pan JAK Inhibitor, On Glucocorticosteroid Resistant Release Of CXCR3 Chemokines From Human bronchial Epithelial Cells (2010) (0)
- Molecular biology. Inflammatory activities. (1991) (0)
- Airway mucosal blood flow : response to automonic and inflammatory stimuli. Discussion (1990) (0)
- Chapter 53 – Mediator Antagonists (2002) (0)
- CHAPTER 90 – Genomic Aspects of Chronic Obstructive Pulmonary Disease (2009) (0)
- Increased α- and Reduced β-Adrenoreceptor Numbers in Experimental Asthma (1980) (0)
- Increased susceptibility of M2 monocyte-derived macrophages from COPD patients to oxidative stress (2013) (0)
- Chapter 33 – Pathophysiology of Asthma (2009) (0)
- Inhibition of Th2 Cytokine Production from Differentiated T Cells by a Novel Anti-Inflammatory Agent. (2009) (0)
- Inhibition ofinterleukin-8 expression bydexamethasone inhuman cultured airwayepithelial cells (1993) (0)
- ESSENTIALS OF COPD ESSENTIALS OF COPD (2005) (0)
- Increased Expression Of Aquaporin 5 In Bronchial Glands Of Smokers With Or Without COPD (2010) (0)
- Long-Acting Inhaled Beta2 Receptor Agonist Drugs (2020) (0)
- Novel targets and therapies in COPD (2012) (0)
- o-Adrenoceptor binding in guinea-pig lung using [3H]-prazosin (2007) (0)
- EVS7-4 Scientific rationale for combination inhalers (2006) (0)
- Contents Vol. 72, 2005 (2005) (0)
- Do ICS/LABA fixed combinations provide superior asthma control compared to separate inhalers? (2010) (0)
- Accelerated Lung Aging and Cellular Senescence in COPD (2020) (0)
- SERIES "NONINVASIVE MONITORING OF AIRWAY INFLAMMATION" Edited by H. Magnussen and F.E. Hargreave Number 4 in this Series Clinical aspects of exhaled nitric oxide (2000) (0)
- 41 – Mediator Antagonists (1998) (0)
- Steroids Selectively Increase β-Adrenoceptors in Foetal Alveoli: Autoradiographic Evidence (1983) (0)
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