Peter J. Ratcliffe
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British biologist & Nobel laureate in medicine
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Why Is Peter J. Ratcliffe Influential?
(Suggest an Edit or Addition)According to Wikipedia, Sir Peter John Ratcliffe, FRS, FMedSci is a British Nobel Laureate physician-scientist who is trained as a nephrologist. He was a practising clinician at the John Radcliffe Hospital, Oxford and Nuffield Professor of Clinical Medicine and head of the Nuffield Department of Clinical Medicine at the University of Oxford from 2004 to 2016. He has been a Fellow of Magdalen College, Oxford since 2004. In 2016 he became Clinical Research Director at the Francis Crick Institute, retaining a position at Oxford as a member of the Ludwig Institute of Cancer Research and director of the Target Discovery Institute, University of Oxford.
Peter J. Ratcliffe's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis (1999) (4924)
- C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation (2001) (3193)
- Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. (2008) (2636)
- Regulation of angiogenesis by hypoxia: role of the HIF system (2003) (2328)
- Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis (1998) (2183)
- Oxygen sensing by HIF hydroxylases (2004) (1916)
- Hypoxia-inducible expression of tumor-associated carbonic anhydrases. (2000) (1265)
- The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages (2000) (1112)
- Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. (1997) (1071)
- Independent function of two destruction domains in hypoxia‐inducible factor‐α chains activated by prolyl hydroxylation (2001) (1062)
- Differential Function of the Prolyl Hydroxylases PHD1, PHD2, and PHD3 in the Regulation of Hypoxia-inducible Factor* (2004) (984)
- Contrasting Properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-Associated Renal Cell Carcinoma (2005) (912)
- HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability. (2005) (889)
- Hypoxia Inducible Factor-α Binding and Ubiquitylation by the von Hippel-Lindau Tumor Suppressor Protein* (2000) (858)
- The oncometabolite 2‐hydroxyglutarate inhibits histone lysine demethylases (2011) (851)
- Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization (2009) (781)
- Widespread, hypoxia‐inducible expression of HIF‐2α in distinct cell populations of different organs (2003) (748)
- Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha. (1998) (686)
- Hypoxia-inducible Factor (HIF) Asparagine Hydroxylase Is Identical to Factor Inhibiting HIF (FIH) and Is Related to the Cupin Structural Family* (2002) (681)
- HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors. (2001) (651)
- High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq. (2011) (637)
- Dynamic regulatory network controlling Th17 cell differentiation (2013) (626)
- Role of HIF-1 alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis (vol 394, pg 485, 1998) (1998) (579)
- Hypoxia and Mitochondrial Inhibitors Regulate Expression of Glucose Transporter-1 via Distinct Cis-acting Sequences (*) (1995) (579)
- Hypoxic Regulation of Lactate Dehydrogenase A (1995) (564)
- Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit* (1997) (540)
- Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys. (2002) (528)
- Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts* (2009) (515)
- Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer. (1994) (509)
- Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix. (2001) (508)
- HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron. (2002) (499)
- Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling (2011) (491)
- Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism (2008) (482)
- Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL (2002) (454)
- Concordant Regulation of Gene Expression by Hypoxia and 2-Oxoglutarate-dependent Dioxygenase Inhibition (2006) (443)
- Prognostic significance of a novel hypoxia-regulated marker, carbonic anhydrase IX, in invasive breast carcinoma. (2001) (431)
- The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. (2000) (413)
- Activation of the HIF pathway in cancer. (2001) (411)
- Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia. (2003) (402)
- Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism. (1993) (400)
- Targeting gene expression to hypoxic tumor cells (1997) (395)
- Identification of the renal erythropoietin-producing cells using transgenic mice. (1993) (393)
- Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease. (2001) (364)
- Oxygen sensing, hypoxia-inducible factor-1 and the regulation of mammalian gene expression. (1998) (357)
- Structure of Factor-inhibiting Hypoxia-inducible Factor (HIF) Reveals Mechanism of Oxidative Modification of HIF-1α* (2003) (344)
- Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells. (2003) (337)
- Oxygen sensors and angiogenesis. (2002) (326)
- Factors influencing success of clinical genome sequencing across a broad spectrum of disorders (2015) (319)
- Signalling hypoxia by HIF hydroxylases. (2005) (314)
- Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling (2000) (288)
- Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival (2014) (288)
- Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents. (1995) (284)
- Expression of hypoxia-inducible factors in human renal cancer: relationship to angiogenesis and to the von Hippel-Lindau gene mutation. (2002) (282)
- Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha. (2008) (279)
- Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH) (2006) (271)
- Carbonic anhydrase IX, an endogenous hypoxia marker, expression in head and neck squamous cell carcinoma and its relationship to hypoxia, necrosis, and microvessel density. (2001) (268)
- Genotype at a promoter polymorphism of the interleukin-6 gene is associated with baseline levels of plasma C-reactive protein. (2002) (265)
- Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways (2014) (264)
- The Role of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) in Hypoxic Induction of Gene Expression (1996) (262)
- The human side of hypoxia-inducible factor (2008) (258)
- Oxygen-regulated and Transactivating Domains in Endothelial PAS Protein 1: Comparison with Hypoxia-inducible Factor-1α* (1999) (256)
- HIF-1 and HIF-2: working alone or together in hypoxia? (2007) (255)
- Functional analysis of an oxygen-regulated transcriptional enhancer lying 3' to the mouse erythropoietin gene. (1991) (255)
- Feedback modulation of renal and hepatic erythropoietin mRNA in response to graded anemia and hypoxia. (1992) (252)
- Polycystin, the polycystic kidney disease 1 protein, is expressed by epithelial cells in fetal, adult, and polycystic kidney. (1996) (251)
- Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer (2013) (243)
- Expression of the hypoxia-inducible and tumor-associated carbonic anhydrases in ductal carcinoma in situ of the breast. (2001) (243)
- Organ distribution of the three rat endothelin messenger RNAs and the effects of ischemia on renal gene expression. (1992) (238)
- Control of the Hypoxic Response in Drosophila melanogaster by the Basic Helix-Loop-Helix PAS Protein Similar (2002) (231)
- Aberrant succination of proteins in fumarate hydratase‐deficient mice and HLRCC patients is a robust biomarker of mutation status (2011) (231)
- HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O2 levels (2003) (225)
- Measured haplotype analysis of the angiotensin-I converting enzyme gene. (1998) (221)
- Hypoxia, Hypoxia-inducible Transcription Factors, and Renal Cancer. (2016) (221)
- The macrophage – a novel system to deliver gene therapy to pathological hypoxia (2000) (219)
- HLA has strongest association with IgA nephropathy in genome-wide analysis. (2010) (216)
- The hypoxia‐inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens (2011) (215)
- Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL. (2002) (213)
- The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis. (2003) (208)
- ENDOTHELIN: AN IMPORTANT FACTOR IN ACUTE RENAL FAILURE? (1988) (207)
- Abnormal Sympathoadrenal Development and Systemic Hypotension in PHD3−/− Mice (2008) (206)
- Asparaginyl Hydroxylation of the Notch Ankyrin Repeat Domain by Factor Inhibiting Hypoxia-inducible Factor* (2007) (206)
- Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain. (2001) (204)
- Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay. (2007) (200)
- Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha-subunit (HIF-1alpha). Characterization of hif-1alpha-dependent and -independent hypoxia-inducible gene expression. (1998) (194)
- Genetic susceptibility for human familial essential hypertension in a region of homology with blood pressure linkage on rat chromosome 10. (1997) (191)
- First United Kingdom Heart and Renal Protection (UK-HARP-I) study: biochemical efficacy and safety of simvastatin and safety of low-dose aspirin in chronic kidney disease. (2005) (189)
- Mutation of von Hippel–Lindau Tumour Suppressor and Human Cardiopulmonary Physiology (2006) (184)
- Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice. (2011) (180)
- Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies (2009) (175)
- Effects of iron supplementation and depletion on hypoxic pulmonary hypertension: two randomized controlled trials. (2009) (167)
- Late referral for maintenance dialysis. (1984) (164)
- Regulation of human metabolism by hypoxia-inducible factor (2010) (155)
- PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase. (2010) (154)
- Mechanisms of hypoxia signalling: new implications for nephrology (2019) (151)
- The increase in pulmonary arterial pressure caused by hypoxia depends on iron status (2008) (150)
- Extensive regulation of the non-coding transcriptome by hypoxia: role of HIF in releasing paused RNApol2 (2013) (149)
- Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression (2012) (148)
- Genetic Analysis of Pathways Regulated by the von Hippel-Lindau Tumor Suppressor in Caenorhabditis elegans (2004) (147)
- 2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase. (2003) (143)
- Carbonic anhydrase XII is a marker of good prognosis in invasive breast carcinoma (2003) (142)
- Differential Sensitivity of Hypoxia Inducible Factor Hydroxylation Sites to Hypoxia and Hydroxylase Inhibitors* (2011) (142)
- The pVHL-associated SCF ubiquitin ligase complex: Molecular genetic analysis of elongin B and C, Rbx1 and HIF-1α in renal cell carcinoma (2001) (141)
- Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans. (2012) (131)
- Genetic Analysis of the Role of the Asparaginyl Hydroxylase Factor Inhibiting Hypoxia-inducible Factor (HIF) in Regulating HIF Transcriptional Target Genes* (2004) (131)
- 5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation. (2013) (131)
- Loss or silencing of the PHD1 prolyl hydroxylase protects livers of mice against ischemia/reperfusion injury. (2010) (130)
- Proteomics-based Identification of Novel Factor Inhibiting Hypoxia-inducible Factor (FIH) Substrates Indicates Widespread Asparaginyl Hydroxylation of Ankyrin Repeat Domain-containing Proteins*S⃞ (2009) (125)
- The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity (2012) (120)
- HIF hydroxylase pathways in cardiovascular physiology and medicine. (2015) (120)
- Age-dependent expression of the erythropoietin gene in rat liver and kidneys. (1992) (119)
- Identification of hypoxically inducible mRNAs in HeLa cells using differential-display PCR. Role of hypoxia-inducible factor-1. (1996) (118)
- New horizons in hypoxia signaling pathways (2017) (116)
- Prediction of patient responses to antihypertensive drugs using genetic polymorphisms: investigation of renin-angiotensin system genes. (1996) (114)
- Organ distribution of erythropoietin messenger RNA in normal and uremic rats. (1991) (114)
- Expression of Idh1R132H in the Murine Subventricular Zone Stem Cell Niche Recapitulates Features of Early Gliomagenesis (2016) (113)
- The hypoxia-inducible genes VEGF and CA9 are differentially regulated in superficial vs invasive bladder cancer (2002) (113)
- Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants (2019) (110)
- Pharmacological targeting of the HIF hydroxylases--A new field in medicine development. (2016) (110)
- Determination and comparison of specific activity of the HIF‐prolyl hydroxylases (2004) (110)
- Segregation and linkage analysis of serum angiotensin I-converting enzyme levels: evidence for two quantitative-trait loci. (1995) (109)
- Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. (2012) (109)
- Trans-ethnic fine mapping of a quantitative trait locus for circulating angiotensin I-converting enzyme (ACE). (2001) (108)
- Inherent DNA‐binding specificities of the HIF‐1α and HIF‐2α transcription factors in chromatin (2018) (107)
- Regulation of HIF by the von Hippel‐Lindau Tumour Suppressor: Implications for Cellular Oxygen Sensing (2001) (107)
- Hypoxia response elements. (1997) (107)
- Target gene selectivity of hypoxia-inducible factor-α in renal cancer cells is conveyed by post-DNA-binding mechanisms (2007) (107)
- Gene array of VHL mutation and hypoxia shows novel hypoxia-induced genes and that cyclin D1 is a VHL target gene (2004) (107)
- Peptide blockade of HIFα degradation modulates cellular metabolism and angiogenesis (2002) (107)
- Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy (2014) (106)
- Human AlkB Homologue 5 Is a Nuclear 2-Oxoglutarate Dependent Oxygenase and a Direct Target of Hypoxia-Inducible Factor 1α (HIF-1α) (2011) (106)
- Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism. (2010) (104)
- Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases. (2013) (104)
- HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation. (2006) (104)
- The use of dioxygen by HIF prolyl hydroxylase (PHD1). (2002) (103)
- Tibetans living at sea level have a hyporesponsive hypoxia-inducible factor system and blunted physiological responses to hypoxia (2013) (102)
- Regulation of Type II Transmembrane Serine Proteinase TMPRSS6 by Hypoxia-inducible Factors (2010) (97)
- OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation (2014) (96)
- Distribution of erythropoietin producing cells in rat kidneys during hypoxic hypoxia. (1993) (96)
- Reversion of lethality and growth defects in Fatiga oxygen‐sensor mutant flies by loss of Hypoxia‐Inducible Factor‐α/Sima (2005) (94)
- Optimal Translational Termination Requires C4 Lysyl Hydroxylation of eRF1 (2014) (94)
- Normoxic stabilization of hypoxia-inducible factor-1alpha by modulation of the labile iron pool in differentiating U937 macrophages: effect of natural resistance-associated macrophage protein 1. (2006) (94)
- Molecular mechanisms of carbonic anhydrase IX‐mediated pH regulation under hypoxia (2008) (94)
- correction: Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis (1998) (94)
- The pVHL-hIF-1 system. A key mediator of oxygen homeostasis. (2001) (93)
- Sites of erythropoietin production. (1997) (90)
- Expression of a homologously recombined erythopoietin-SV40 T antigen fusion gene in mouse liver: evidence for erythropoietin production by Ito cells. (1994) (90)
- Increased plasma viscosity as a reason for inappropriate erythropoietin formation. (1993) (90)
- Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2α gain-of-function mutation (2011) (89)
- Regulation of the Drosophila bHLH-PAS protein Sima by hypoxia: functional evidence for homology with mammalian HIF-1 alpha. (1998) (87)
- Increased Angiogenesis Protects against Adipose Hypoxia and Fibrosis in Metabolic Disease-resistant 11β-Hydroxysteroid Dehydrogenase Type 1 (HSD1)-deficient Mice* (2011) (87)
- Oxygen-dependent modulation of erythropoietin mRNA levels in isolated rat kidneys studied by RNase protection (1990) (86)
- Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases (2016) (86)
- New insights into an enigmatic tumour suppressor (2003) (86)
- The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity (2012) (83)
- U.K. Prospective Diabetes Study. XV: Relationship of renin-angiotensin system gene polymorphisms with microalbuminuria in NIDDM. (1995) (83)
- Rapid genetic analysis of families with polycystic kidney disease 1 by means of a microsatellite marker (1991) (82)
- FIH‐Dependent Asparaginyl Hydroxylation of Ankyrin Repeat Domain‐Containing Proteins (2009) (79)
- Pan-genomic binding of hypoxia-inducible transcription factors (2013) (79)
- A Role for Cytosolic Fumarate Hydratase in Urea Cycle Metabolism and Renal Neoplasia (2013) (79)
- Regulation of growth differentiation factor 15 expression by intracellular iron. (2009) (76)
- Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity. (2004) (75)
- Electrocardiographic measures of left ventricular hypertrophy show greater heritability than echocardiographic left ventricular mass. (2002) (74)
- Clinical iron deficiency disturbs normal human responses to hypoxia (2016) (73)
- The interstitial response to renal injury: fibroblast-like cells show phenotypic changes and have reduced potential for erythropoietin gene expression. (1997) (73)
- Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors. (2012) (73)
- Insulin-like growth factors decrease oxygen-regulated erythropoietin production by human hepatoma cells (Hep G2). (1992) (72)
- Expression of Hypoxia-Inducible Factor-1 (cid:1) and -2 (cid:1) in Hypoxic and Ischemic Rat Kidneys (2002) (70)
- Oxygen sensing and hypoxia-induced responses. (2007) (70)
- Cellular oxygen sensing in health and disease (2008) (69)
- Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer (2016) (69)
- Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains (2011) (68)
- Hif-2α is not essential for cell-autonomous hematopoietic stem cell maintenance. (2013) (67)
- Adult hematopoietic stem cells lacking Hif-1α self-renew normally. (2016) (66)
- Asparagine and Aspartate Hydroxylation of the Cytoskeletal Ankyrin Family Is Catalyzed by Factor-inhibiting Hypoxia-inducible Factor* (2010) (64)
- Interaction of Hydroxylated Collagen IV with the von Hippel-Lindau Tumor Suppressor* (2007) (64)
- Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses (2017) (64)
- Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility (2010) (63)
- Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases* (2016) (63)
- Leu‐574 of human HIF‐1α is a molecular determinant of prolyl hydroxylation (2004) (63)
- Drosophila melanogaster SL2 cells contain a hypoxically inducible DNA binding complex which recognises mammalian HIF‐1 binding sites (1996) (61)
- Targeting tumors through the HIF system (2000) (60)
- Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected]. (2004) (60)
- Mutation analysis of hypoxia-inducible factors HIF1A and HIF2A in renal cell carcinoma. (2009) (60)
- Regulation of ventilatory sensitivity and carotid body proliferation in hypoxia by the PHD2/HIF‐2 pathway (2015) (59)
- Capture‐C reveals preformed chromatin interactions between HIF‐binding sites and distant promoters (2016) (59)
- Gene panel sequencing improves the diagnostic work-up of patients with idiopathic erythrocytosis and identifies new mutations (2016) (59)
- Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases. (2003) (58)
- Clinical importance of acquired cystic disease of the kidney in patients undergoing dialysis. (1983) (58)
- Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance (2015) (57)
- A Ribosomopathy Reveals Decoding Defective Ribosomes Driving Human Dysmorphism. (2017) (57)
- Regulation of HIF: prolyl hydroxylases. (2006) (56)
- Evidence for abnormal Na+/H+ antiport activity detected by phosphorus nuclear magnetic resonance spectroscopy in exercising skeletal muscle of patients with essential hypertension. (1990) (55)
- The HIF prolyl hydroxylase PHD3 is a potential substrate of the TRiC chaperonin (2004) (54)
- Characterization of different isoforms of the HIF prolyl hydroxylase PHD1 generated by alternative initiation. (2006) (54)
- From Erythropoietin to Oxygen: Hypoxia-Inducible Factor Hydroxylases and the Hypoxia Signal Pathway (2002) (54)
- Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2 (2013) (54)
- The HIF pathway: implications for patterns of gene expression in cancer. (2001) (53)
- On the pivotal role of PPARα in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury (2016) (51)
- A cross-sectional study of the prevalence and associations of iron deficiency in a cohort of patients with chronic obstructive pulmonary disease (2015) (50)
- Heterogeneous Effects of Direct Hypoxia Pathway Activation in Kidney Cancer (2015) (50)
- Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2. (2007) (50)
- The SIN3A histone deacetylase complex is required for a complete transcriptional response to hypoxia (2017) (50)
- Characterisation of functional domains within the mouse erythropoietin 3' enhancer conveying oxygen-regulated responses in different cell lines. (1994) (49)
- Puzzling Patterns of Predisposition (2009) (49)
- Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates (2019) (48)
- Fumarate hydratase deficiency and cancer: activation of hypoxia signaling? (2007) (47)
- Direct nephrotoxicity of Russell's viper venom demonstrated in the isolated perfused rat kidney. (1989) (47)
- Asparagine beta-hydroxylation stabilizes the ankyrin repeat domain fold. (2009) (47)
- Regulation of the erythropoietin gene. (1995) (47)
- A photoreactive small-molecule probe for 2-oxoglutarate oxygenases. (2011) (47)
- Hypoxic and pharmacological activation of HIF inhibits SARS-CoV-2 infection of lung epithelial cells (2020) (47)
- Oxygen regulated gene expression: erythropoietin as a model system. (1997) (47)
- Adipocyte Pseudohypoxia Suppresses Lipolysis and Facilitates Benign Adipose Tissue Expansion (2014) (45)
- Erythrocytes alter the pattern of renal hypoxic injury: predominance of proximal tubular injury with moderate hypoxia. (1989) (45)
- Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth (2014) (44)
- MASSIVE THROMBOSIS AROUND SUBCLAVIAN CANNULAS USED FOR HAEMODIALYSIS (1982) (44)
- Cerebrovascular disease in dementia: the importance of atrial fibrillation. (1985) (42)
- Bleeding oesophageal varices and hepatic dysfunction in adult polycystic kidney disease. (1984) (42)
- Signaling hypoxia by hypoxia-inducible factor protein hydroxylases: a historical overview and future perspectives (2014) (41)
- Molecular biology of erythropoietin. (1993) (41)
- Faculty Opinions recommendation of Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3. (2002) (40)
- Sodium sulfite is a potential hypoxia inducer that mimics hypoxic stress in Caenorhabditis elegans (2011) (39)
- Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain (2015) (39)
- Erratum: Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival (2015) (39)
- Roles of individual prolyl‐4‐hydroxylase isoforms in the first 24 hours following transient focal cerebral ischaemia: insights from genetically modified mice (2012) (38)
- Erythrocytosis associated with a novel missense mutation in the BPGM gene (2010) (37)
- Pathways for Oxygen Regulation and Homeostasis: The 2016 Albert Lasker Basic Medical Research Award. (2016) (35)
- Selection of Mutant CHO Cells with Constitutive Activation of the HIF System and Inactivation of the von Hippel-Lindau Tumor Suppressor* (2001) (35)
- Effect of inhibitors of oxidative phosphorylation on erythropoietin mRNA in isolated perfused rat kidneys. (1991) (35)
- Delivery of erythropoietin by encapsulated myoblasts in a genetic model of severe anemia. (2002) (35)
- Understanding hypoxia signalling in cells--a new therapeutic opportunity? (2006) (33)
- Signalling cross talk of the HIF system: involvement of the FIH protein. (2009) (33)
- The prolyl hydroxylase enzymes that act as oxygen sensors regulating destruction of hypoxia-inducible factor alpha. (2004) (32)
- Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway (2017) (30)
- PHD2 inactivation in Type I cells drives HIF‐2α‐dependent multilineage hyperplasia and the formation of paraganglioma‐like carotid bodies (2018) (30)
- Genetic evidence of a precisely tuned dysregulation in the hypoxia signaling pathway during oncogenesis. (2014) (30)
- Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases. (2015) (29)
- Comparison of the human and mouse erythropoietin genes shows extensive homology in the flanking regions. (1993) (29)
- MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH). (2009) (29)
- The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases (2018) (27)
- Systemic silencing of Phd2 causes reversible immune regulatory dysfunction (2019) (26)
- ExCITED about HIF (2003) (26)
- Acute renal failure in hemorrhagic hypotension: cellular energetics and renal function. (1986) (26)
- Leu-574 of human HIF-1alpha is a molecular determinant of prolyl hydroxylation. (2004) (26)
- Striking Oxygen Sensitivity of the Peptidylglycine α-Amidating Monooxygenase (PAM) in Neuroendocrine Cells* (2015) (25)
- Insights into the Role of the von Hippel-Lindau Gene Product (2001) (25)
- A large duplicated area in the polycystic kidney disease 1 (PKD1) region of chromosome 16 is prone to rearrangement. (1994) (25)
- 31P nuclear magnetic resonance study of steady-state adenosine 5'-triphosphate levels during graded hypoxia in the isolated perfused rat kidney. (1988) (24)
- Renal cyst formation in Fh 1-deficient mice is independent of the Hif / Phd pathway (2011) (23)
- Renal innervation plays no role in oxygen-dependent control of erythropoietin mRNA levels. (1992) (23)
- Selection and Analysis of a Mutant Cell Line Defective in the Hypoxia-inducible Factor-1 α-Subunit (HIF-1α) (1998) (23)
- Update on hypoxia-inducible factors and hydroxylases in oxygen regulatory pathways: from physiology to therapeutics (2017) (23)
- Production of Erythropoietin by Liver Cells in Vivo and in Vitro (1994) (22)
- Quantitative Mass Spectrometry Reveals Dynamics of Factor-inhibiting Hypoxia-inducible Factor-catalyzed Hydroxylation* (2011) (21)
- Marked and rapid effects of pharmacological HIF-2α antagonism on hypoxic ventilatory control (2020) (20)
- Mutation of the von Hippel-Lindau gene alters human cardiopulmonary physiology. (2008) (20)
- Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex. (2002) (19)
- UK Prospective Diabetes Study (UKPDS) 14: association of angiotensin-converting enzyme insertion/deletion polymorphism with myocardial infarction in NIDDM (1995) (19)
- The HIF complex recruits the histone methyltransferase SET1B to activate specific hypoxia-inducible genes (2021) (19)
- 87-rubidium NMR: a novel method of measuring cation flux in intact kidney. (1989) (18)
- Expression of endothelins 1 and 3 in the rat kidney. (1995) (18)
- Hypercholesterolaemia and vascular disease after transplantation (1991) (18)
- Evaluation of aspirin metabolites as inhibitors of hypoxia-inducible factor hydroxylases. (2008) (17)
- Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion. (2013) (17)
- Modls: Post-translational modification localization scoring with automatic specificity expansion (2012) (16)
- Phorbol ester inhibits erythropoietin production in human hepatoma cells (Hep G2). (1992) (16)
- The lens after renal transplantation. (1990) (16)
- Angiogenesis: escape from hypoxia (2009) (16)
- A competitive radioimmunoassay using a monoclonal antibody to detect the factor X activator of Russell's viper venom. (1987) (15)
- Timing of the onset of changes in renal energetics in relation to blood pressure and glomerular filtration in haemorrhagic hypotension in the rat. (1989) (15)
- Influence of hypoxia on hepatic and renal endothelin gene expression (1996) (14)
- Hypoxia drives glucose transporter 3 expression through hypoxia-inducible transcription factor (HIF)–mediated induction of the long noncoding RNA NICI (2019) (14)
- Regulation of gene expression by oxygen levels in mammalian cells. (1999) (13)
- Rapid oxygen-dependent changes in erythropoietin mRNA in perfused rat kidneys: evidence against mediation by cAMP. (1992) (12)
- Structure‐Activity Relationship and Crystallographic Studies on 4‐Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors (2019) (12)
- Ischaemic acute renal failure: why does it occur? (1989) (12)
- Regulation of expression of the erythropoietin gene (1998) (12)
- Recurrent cerebral abscess in association with pulmonary arteriovenous fistulae. (1982) (11)
- Bleeding Esophageal Varices and Hepatic Dysfunction in Adult Polycystic Kidney Disease (1984) (11)
- Hyperplasia of pulmonary neuroepithelial bodies (NEB) in lungs of prolyl hydroxylase -1(PHD-1) deficient mice. (2012) (10)
- Analysis of Cis‐acting Sequences Required for Operation of the Erythropoietin 3’Enhancer in Different Cell Lines a (1994) (10)
- Tubular reabsorption rates for myoglobin in the isolated perfused rat kidney. (1986) (10)
- Oxygen-dependent expression of the erythropoietin gene in rat hepatocytes in vitro (1993) (9)
- Beyond erythropoietin: the oxygen sensor. (1997) (9)
- Co-incidence of RCC-susceptibility polymorphisms with HIF cis-acting sequences supports a pathway tuning model of cancer (2019) (9)
- Microencapsulated octreotide pamoate in advanced gastrointestinal and pancreatic cancer: a phase I study. (1998) (9)
- Hyperplasia and hypertrophy of pulmonary neuroepithelial bodies, presumed airway hypoxia sensors, in hypoxia-inducible factor prolyl hydroxylase-deficient mice (2016) (9)
- Long-term survival following left ventricular aneurysmectomy. (1983) (9)
- Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation (2022) (8)
- Erratum: Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hyposia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes (Journal of Biological Chemistry (2004) 279 (42719-42725)) (2004) (7)
- HEMATOPOIESIS AND STEM CELLS Hif-2 a is not essential for cell-autonomous hematopoietic stem cell maintenance (2013) (6)
- Photoactivable peptides for identifying enzyme-substrate and protein-protein interactions. (2011) (6)
- Novel Insights into FH-associated Disease are KEAPing the Lid on Oncogenic HIF Signalling (2011) (6)
- Genetic basis of oxygen sensing in the carotid body: HIF2α and an isoform switch in cytochrome c oxidase subunit 4 (2020) (6)
- CAIX expression, a potential intrinisic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in localy advanced carcinoma of the cervix (2001) (6)
- MORPHINE TRANSPORT IN THE ISOLATED PERFUSED RAT-KIDNEY (1985) (6)
- For their discoveries of how cells sense and adapt to oxygen availability (2019) (5)
- Quantification of 32P-labeled samples in gel fragments using the flat-bed liquid scintillation counter. (1991) (5)
- Augmented 5-HT Secretion in Pulmonary Neuroepithelial Bodies from PHD1 Null Mice. (2015) (5)
- Precisely Tuned Inhibition of HIF Prolyl Hydroxylases Is Key for Cardioprotection After Ischemia (2021) (5)
- Evidence for the presence of oligophosphoglyceroyl-ATP in rat offney. (1986) (5)
- Hypoxia drives glucose transporter 3 expression through hypoxia-inducible transcription factor (HIF)-mediated induction of the long noncoding RNA NICI. (2020) (5)
- Nuclear entry and export of FIH are mediated by HIF1α and exportin1, respectively (2018) (4)
- Prevention and Reversal of Mercuric Chloride-Induced Increases in Renal Vascular Resistance by Captopril (1989) (4)
- Nuclear magnetic resonance studies of87Rb+transport in perfused rat kidney (1988) (4)
- Erythropoietin‐producing Cells in Transgenic Mice Expressing SV40 Large T Antigen Directed by Erythropoietin Control Sequences (1994) (4)
- ACUTE RENAL-FAILURE IN THE ISOLATED PERFUSED KIDNEY, INDUCED BY RUSSELLS VIPER VENOM (1985) (4)
- Evidence for a quantitative trait locus for plasma fibrinogen from a family–based association study (2001) (4)
- Oxygen Sensing and Erythropoietin mRNA Production in Isolated Perfused Rat Kidneys (1992) (3)
- Hypoxia drives glucose transporter 3 expression through HIF-mediated induction of the long noncoding RNA NICI (2019) (3)
- The erythropoietin-producing cells. (1996) (3)
- The Isolated Perfused Rat Kidney: Filtering and Non-Filtering Models in the Assessment of Altered Renal Vascular Resistance in Nephrotoxicity (1989) (3)
- Unlocking the complexity of hypoxia non-coding transcriptome landscape of breast cancer (2014) (3)
- Developmental role of PHD2 in the pathogenesis of pseudohypoxic pheochromocytoma (2021) (3)
- Development of branched structures and the cellular response to hypoxia: An evolutionary perspective (2001) (3)
- The MRC British Genetics of Hypertension Study - Genome-wide screen results (2002) (3)
- Hypoxia, Erythropoietin Gene Expression, and Erythropoiesis (2011) (3)
- Benefits and Risks of Manipulating the HIF Hydroxylase Pathway in Ischemic Heart Disease (2012) (3)
- Analysis of von Hippel-Lindau tumor suppressor as a mediator of cellular oxygen sensing. (2004) (3)
- HEMATOPOIESIS AND STEM CELLS Adult hematopoietic stem cells lacking Hif-1 a self-renew normally (2016) (2)
- Prolyl Hydroxylase Phd3 Is Essential For Hypoxic Regulation Of Neutrophilic Inflammation (2011) (2)
- New HIF2α inhibitors: potential implications as therapeutics for advanced pheochromocytomas and paragangliomas (2017) (2)
- Abnormal whole-body energy metabolism in iron-deficient humans despite preserved skeletal muscle oxidative phosphorylation (2022) (2)
- Clinical Importance of Acquired Cystic Disease of the Kidney in Patients Undergoing Dialysis (1984) (2)
- Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways (2014) (2)
- Genome-Wide Analysis Identifies Strong Association Between HLA and IgA Nephropathy (2010) (2)
- A new tool for checks of data precision within the MRC British genetics of hypertension study (2000) (2)
- A Comprehensive Study of the VHL-R200W Chuvash Polycythemia Mutation Reveals a Gradual Dysregulation of the Hypoxia Pathway in Oncogenesis (2014) (2)
- Author response: Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates (2019) (2)
- The role of 2-oxoglutarate dependent dioxygenases in normal haematopoiesis and acute myeloid leukemia (2015) (2)
- Endothelial Oxygen Sensing in Alveolar Maintenance (2020) (2)
- Gene regulation by hypoxia (2000) (2)
- 31P nuclear magnetic resonance in the investigation of renal ischemia during hypotension. (1987) (1)
- Oxygen Sensing and Vascular Growth Factor Gene Expression: Comparison with Erythropoietin Regulation (1995) (1)
- RAPID GENETIC-ANALYSIS OF POLYCYSTIC KIDNEY DISEASE-1 (PKD1) FAMILIES WITH A CLOSELY LINKED, HIGHLY POLYMORPHIC MICROSATELLITE (1991) (1)
- Erythropoietin: An Historical Overview of Physiology, Molecular Biology and Gene Regulation (2008) (1)
- Erratum: Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis (Nature (1998) 394 (485-490)) (1998) (1)
- No support for linkage of chromosome 17(q21-24) to Essential Hypertension in the MRC British Genetics of Hypertension (MRC BRIGHT) Study. (2001) (1)
- Prognostic S ignificance o f a N ovel H ypoxia-Regulate d Marker, C arbonic A nhydrase I X, i n I nvasive B reast Carcinoma (2001) (1)
- OXYGEN-DEPENDENT EXPRESSION OF ERYTHROPOIETIN MESSENGER-RNA IN RAT KIDNEYS (1995) (1)
- The acute hypoxic ventilatory response is augmented in PHD2-deficient mice (2008) (1)
- Factor inhibiting HIF can catalyze two asparaginyl hydroxylations in VNVN motifs of ankyrin fold proteins (2022) (1)
- Advances in Brief Predominant Role of Hypoxia-Inducible Transcription Factor ( Hif )-1 versus Hif-2 in Regulation of the Transcriptional Response to Hypoxia 1 (2003) (1)
- Isoform-resolved mRNA profiling of ribosome load defines interplay of HIF and mTOR dysregulation in kidney cancer (2022) (1)
- Widespread hydroxylation of unstructured lysine-rich protein domains by JMJD6 (2022) (1)
- Regulation of HIF-1 by oxygen: The role of prolyl hydroxylase and the VHL tumor suppressor (2003) (1)
- P-31 MAGNETIC-RESONANCE SPECTROSCOPY IN RENAL ISCHEMIA (1986) (1)
- Erratum: Predominant role of hypoxia-inducible transcription factor (Hif)-1α versus Hif-2α in regulation of the transcriptional response to hypoxia (Cancer Research (October 1, 2003)(6130-6134)) (2003) (1)
- Analysis of the angiotensinogen gene in the MRC British genetics of Hypertension study. (2015) (1)
- HIF and cancer (2003) (1)
- Harveian Oration 2020: Elucidation of molecular oxygen sensing mechanisms in human cells: implications for medicine. (2021) (1)
- A cross-sectional study of the prevalence and associations of iron de fi ciency in a cohort of patients with chronic obstructive pulmonary disease (2015) (1)
- 31Phosphorus NMR Studies of Mercuric Chloride Nephrotoxicity in the in Vitro Perfused Rat Kidney (1989) (1)
- MOLECULAR VARIANTS OF THE RENIN-ANGIOTENSIN SYSTEM DO NOT PREDICT RESPONSE TO ANTIHYPERTENSIVE AGENTS (1994) (1)
- Erythropoietin: Effects on Haem Biosynthesis (2000) (1)
- Hypoxia Signalling and Disease (2010) (0)
- Cerebrovascular disease indementia: theimportance ofatrial fibrillation (1985) (0)
- Oxygen-regulated gene expression in mammalian cells (1997) (0)
- Abstract 119: Pan-cancer analysis of HIF pathways defines a robust molecular signature that reflects tissue and cellular hypoxia in bulk and single-cell RNA-seq analyses (2022) (0)
- A LARGE DUPLICATED AREA ON THE PROXIMAL EDGE OF THE POLYCYSTIC KIDNEY-DISEASE-1 (PKDI) REGION IS PRONE TO REARRANGEMENT (1995) (0)
- SET1B facilitates activation of the hypoxia response through site-specific histone methylation (2020) (0)
- Expression of Hypoxia-inducible Factors in Human Renal Cancer : Relationship to Angiogenesis and to the von Hippel-Lindau Gene Mutation 1 (2002) (0)
- erratum Perinuclear localizationof chromatin facilitates transcriptional silencing (0)
- Increased sensitivity to glucose deprivation in HIF-1B/ARNT deficient cells compared to parental cells - a contributing factor to ereduced xenograft growth? (1998) (0)
- Synergistic inhibition of tumour cell proliferation and upregulation of Hif-1 alpha using two anti-transferrin receptor antibodies. (2004) (0)
- HIF inhibitors for use in the treatment of anemia hydroxylase. (2003) (0)
- Electrocardiographic markers of cardiac hypertrophy show greater heritability than echocardiographic left ventricular mass: A family study (2002) (0)
- Abstract A29: Hypoxia regulated long noncoding RNAs and antisense transcripts in breast cancer: Novel insights of noncoding transcriptional regulation in hypoxic microenvironment (2016) (0)
- Fibroblast-like cells in renal injury show phenotypic changes and hare reduced potential for erythropoietin gene expression. (1999) (0)
- A novel promoter-enhancer for hypoxia-selective gene therapy. (2002) (0)
- Erratum. Adipocyte Pseudohypoxia Suppresses Lipolysis and Facilitates Benign Adipose Tissue Expansion. Diabetes 2015;64:733–745 (2021) (0)
- University of Birmingham Mutation analysis of HIF-prolylhydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility (2010) (0)
- Selection of a Mutant Cell Line Defective in Hypoxia Inducible Factor Alpha (HIF-1α) (1998) (0)
- Expression of Idh1R132H in the murine subventricular zone stem cell niche recapitulates early gliomagenesis (2016) (0)
- Author Correction: Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation (2022) (0)
- Oncogenic switching of hypoxia signalling pathways (2014) (0)
- atrial fibrillation . dementia : the importance of Cerebrovascular disease in (2008) (0)
- Role of hypoxia-inducible factor-1 (HIF-1) is angiogenesis and tumour biology (1999) (0)
- Ultrastructural characterization of erythropoietin producing cells in the kidney and liver using transgenic mice (1994) (0)
- Crystal structure of a hydroxylated HIF-1 alpha peptide bound to the pVHL/elongin-C/elongin-B complex (2002) (0)
- Characterization of hypoxia inducible factor pathway in neuroprotection and neurorestoration following cerebral ischaemia (2013) (0)
- Hypoxia-Responsive Elements (1997) (0)
- Abstract 677: Bi-directional crosstalk between the HIF and AHR transcription factors in clear cell kidney cancer (2022) (0)
- Abstract P2-05-01: The non-coding transcriptome of hypoxic breast cancer: Novel insights of clinical relevant long non-coding RNA in hypoxia signalling (2015) (0)
- Signalling hypoxia by protein hydroxylation: Transcriptional architecture of the HIF response (2017) (0)
- Abstract MP121: Deleting the 2-oxoglutarate- and Iron-dependent Prolyl Hydroxylase Ogfod1 Alters Purine Nucleotide Regulation and is Cardioprotective (2020) (0)
- Abstract 3766: Correlating locus-specific changes in histone trimethylation and gene expression in hypoxia (2022) (0)
- Hypoxia Inducible Factor-1 dependent gene expression in tumours. (1997) (0)
- Differential Regulation Of Neutrophil (pmn) Survival By The Prolyl Hydroxylase Enzymes Phd2 And Phd3 (2013) (0)
- Functional variation in the hypoxia-inducible factor (HIF) pathway in humans (2012) (0)
- Increased Sensitivity to Renal Ischaemia During Haemorrhagic Hypotension Demonstrated in the Spontaneously Hypertensive Rat by31P???Nuclear Magnetic Resonance (1985) (0)
- oss or Silencing of the PHD 1 Prolyl Hydroxylase Protects Livers of Mice gainst Ischemia / Reperfusion Injury (0)
- Oncogenic switching of hypoxia signalling pathways (2014) (0)
- Thelens after renal transplantation (1990) (0)
- Abstract 862: Negative cellular outcomes following acute in vivo Vhl inactivation in mice (2022) (0)
- Pontin and reptin: Two novel regulators of the transcriptional response to hypoxia (2011) (0)
- Loss of the Prolyl Hydroxylase OGFOD1 In Vivo Leads to Metabolic Alterations (2018) (0)
- Elevated 2HG does not cause features of tumorigenesis (2021) (0)
- Multi-level interaction between HIF and AHR transcriptional pathways in kidney carcinoma (2023) (0)
- Differentiation modulates the hypoxia-inducible gene program in macrophages: Effects of alterations in iron homeostasis (2004) (0)
- Elucidation of Oxygen Sensing Mechanisms in Human and Animal Cells (2019) (0)
- Ischaemic Acute Renal Failure in an Intact Animal Model (1990) (0)
- Functional role of the oxygen sensors PHD1, PHD2 and PHD3: a gene-inactivation study in mice (2006) (0)
- Factor Inhibiting HIF (FIH1) modulates cardiac function, calcium kinetics and metabolism (2016) (0)
- Oral Presentations 2 (2004) (0)
- Systemic silencing of HIF hydroxylase PHD2 causes reversible immunoregulatory dysfunction (2019) (0)
- Abstract 3436: Pan-cancer analysis of the HIF-transcriptional pathway and its association with genetic susceptibility to cancer (2020) (0)
- Abstract 1587: Multi region single cell sequencing reveals dedifferentiation programs, angiogenic heterogeneity and the effect of microenvironmental hypoxia in ccRCC tumors (2022) (0)
- Cellular models for characterisation of MINA53, a 2-oxoglutarate-dependent dioxygenase (2012) (0)
- Hif hydroxylase inhibitors for anemia treatment (2003) (0)
- 8-Hydroxyquinoline-5-Carboxylic Acid is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation (2013) (0)
- Advances in Brief Effect of Ascorbate on the Activity of Hypoxia-inducible Factor in Cancer Cells 1 (2003) (0)
- Abstract 939: A novel lineage-tracing model of Vhldeletion reveals time-dependent cellular changes in the kidney (2022) (0)
- 54: Proffered Paper: Hypoxic regulation of the long non-coding transcriptome in breast cancer (2014) (0)
- Contrasting roles of HIF-1 and 2 in ventilatory acclimatisation to hypoxia (2015) (0)
- A physiological study of Tibetan natives at sea level (2012) (0)
- Hypoxia shapes the immune landscape in lung injury promoting inflammation persistence (2022) (0)
- Interaction between the von Hippel-Lindau gene product (pVHL) and hypoxia-inducible factor 1 is disrupted by disease causing pVHL mutants (1999) (0)
- The MRC BRIGHT study: Demographic and biochemical characteristics of the sibling-pair resource (2004) (0)
- The cancer connection : von Hippel – Lindau disease (2016) (0)
- University of Birmingham Expression of Idh1(R132H) in the Murine Subventricular Zone Stem Cell Niche Recapitulates Features of Early Gliomagenesis (0)
- LOWERING HB OXYGEN-AFFINITY PROTECTS AGAINST HYPOXIC RENAL INJURY (1991) (0)
- Host resistance to a gastrointestinal parasite regulated by Mina, an immunoregulatory member of the JmjC protein family (P1014) (2013) (0)
- Cell signalling / renal repair (2013) (0)
- Publisher Correction: Abnormal whole-body energy metabolism in iron-deficient humans despite preserved skeletal muscle oxidative phosphorylation (2022) (0)
- Pan-cancer analysis of tissue and single-cell HIF-pathway activation using a conserved gene signature (2022) (0)
- Abstract 317: Endoplasmic Reticulum Stress Alters the Localization of the Prolyl Hydroxylase Ogfod1 in Adult Mouse Cardiomyocytes (2020) (0)
- Corrigendum: Contrasting effects on HIF-1α regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease. (2021) (0)
- Carbonic anhydrase IX: A highly specific promoter for hypoxia mediated gene therapy. (2003) (0)
- Effect of hypoxia on reporter gene expression in various cell lines Hypoxic Cells Species and type % 02 induction Hep 3 B Human hepatoma (2005) (0)
- A Role For Prolyl Hydroxylase Domain (PHD) Proteins In Respiratory Control (2011) (0)
- Regulation of endogenous erythropoietin production (2009) (0)
- Tumour suppression by a protein hydroxylase (2016) (0)
- HIF-1α Is Not Essential For The Establishment Of MLL-Leukaemic Stem Cells (2013) (0)
- Therapie genique de ciblage (1995) (0)
- How Cells Sense Oxygen (2001) (0)
- Publisher Correction: The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases (2018) (0)
- P-31 NMR study of graded hypoxia in the isolated perfused rat kidney. (1986) (0)
- Phd 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses (2017) (0)
- Increased frequency and earlier onset of pituitary tumours in mice deleted for a multiple endocrine neoplasia type 1 allele and null for prolyl hydroxylase domain protein 1 (Men1+/-/Phd1-/-) (2014) (0)
- The ribosomal prolyl hydroxylase ogfod1 alters the proteomic landscape to protect the heart from injury (2020) (0)
- Isoform resolved measurements of absolute translational efficiency define interplay of HIF and mTOR dysregulation in kidney cancer (2021) (0)
- The HIF hydroxylase pathway and the tumour microenvironment (2008) (0)
- FACTOR INHIBITING HIF (FIH1) MODULATES CARDIAC FUNCTION AND METABOLISM Abstracts (2018) (0)
- A cross-sectional study of the prevalence and associations of iron deficiency in a cohort of patients with chronic obstructive (2015) (0)
- Leading Edge BenchMarks Into Thin Air : HowWe Sense and Respond to Hypoxia (2016) (0)
- New horizons in hypoxia signaling pathways in health and disease (2018) (0)
- Annual Scientific Meeting of the British Hypertension Society, Cambridge, UK, 11–13 September 2000 (2000) (0)
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