Peter James O’brien
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Biology
Peter James O’brien's Degrees
- PhD Genetics Stanford University
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(Suggest an Edit or Addition)Peter James O’brien's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Identification of a mutation in porcine ryanodine receptor associated with malignant hyperthermia. (1991) (1454)
- Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties. (2004) (987)
- Molecular mechanisms of quinone cytotoxicity. (1991) (948)
- High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening (2006) (568)
- Aldehyde Sources, Metabolism, Molecular Toxicity Mechanisms, and Possible Effects on Human Health (2005) (566)
- Prooxidant activity and cellular effects of the phenoxyl radicals of dietary flavonoids and other polyphenolics. (2002) (499)
- An intracellular GSH-peroxidase with a lipid peroxide substrate. (1968) (420)
- Flavonoid B-ring chemistry and antioxidant activity: fast reaction kinetics. (2001) (401)
- Cellular and in vivo hepatotoxicity caused by green tea phenolic acids and catechins. (2006) (348)
- Mitochondrial function and toxicity: role of the B vitamin family on mitochondrial energy metabolism. (2006) (347)
- Intracellular mechanisms for the decomposition of a lipid peroxide. I. Decomposition of a lipid peroxide by metal ions, heme compounds, and nucleophiles. (1969) (327)
- Cardiac troponin I is a sensitive, specific biomarker of cardiac injury in laboratory animals (2006) (286)
- Fanconi anemia group C protein prevents apoptosis in hematopoietic cells through redox regulation of GSTP1 (2001) (255)
- Cardiac troponin is the most effective translational safety biomarker for myocardial injury in cardiotoxicity. (2008) (251)
- Dietary flavonoid iron complexes as cytoprotective superoxide radical scavengers. (2003) (239)
- Cancer Chemoprevention and Apoptosis Mechanisms Induced by Dietary Polyphenolics (2000) (230)
- Properties and regulation of glutathione peroxidase. (1970) (227)
- Metabolic products and pathways of fluorotelomer alcohols in isolated rat hepatocytes. (2005) (222)
- Molecular Mechanisms of Hydrogen Sulfide Toxicity (2006) (221)
- In vivo differential prenylation of retinal cyclic GMP phosphodiesterase catalytic subunits. (1992) (205)
- Peroxidative metabolism of apigenin and naringenin versus luteolin and quercetin: glutathione oxidation and conjugation. (2001) (201)
- Mitochondrial function and toxicity: role of B vitamins on the one-carbon transfer pathways. (2006) (197)
- The formaldehyde metabolic detoxification enzyme systems and molecular cytotoxic mechanism in isolated rat hepatocytes. (2001) (195)
- H2S cytotoxicity mechanism involves reactive oxygen species formation and mitochondrial depolarisation. (2004) (186)
- Differential reactivity of cardiac and skeletal muscle from various species in a cardiac troponin I immunoassay. (1997) (181)
- Mechanism of mitochondrial uncouplers, inhibitors, and toxins: focus on electron transfer, free radicals, and structure-activity relationships. (2005) (179)
- Cytochrome P-450 as a microsomal peroxidase utilizing a lipid peroxide substrate. (1971) (175)
- Carcinogenic metal induced sites of reactive oxygen species formation in hepatocytes. (2003) (173)
- Radical formation during the peroxidase catalyzed metabolism of carcinogens and xenobiotics: the reactivity of these radicals with GSH, DNA, and unsaturated lipid. (1988) (172)
- 2,5‐Di(tert‐butyl)‐1,4‐benzohydroquinone — a novel inhibitor of liver microsomal Ca2+ sequestration (1987) (170)
- Drug-induced mitochondrial toxicity (2005) (166)
- Cardiac troponin T is a sensitive, specific biomarker of cardiac injury in laboratory animals. (1997) (162)
- Boldine and its antioxidant or health-promoting properties. (2006) (161)
- Evaluation of the Substrate Specificity of Human Mast Cell Tryptase βI and Demonstration of Its Importance in Bacterial Infections of the Lung* (2001) (160)
- Quinone toxicity in hepatocytes without oxidative stress. (1986) (158)
- The cytotoxic mechanism of glyoxal involves oxidative stress. (2004) (155)
- Hydroperoxide catalyzed liver microsomal aromatic hydroxylation reactions involving cytochrome P-450. (1974) (152)
- Mechanism of peroxide-inactivation of the sulphydryl enzyme glyceraldehyde-3-phosphate dehydrogenase. (1969) (148)
- Advantages of glutamate dehydrogenase as a blood biomarker of acute hepatic injury in rats (2002) (142)
- Glutathione-dependent generation of reactive oxygen species by the peroxidase-catalyzed redox cycling of flavonoids. (1999) (140)
- Idiosyncratic NSAID drug induced oxidative stress. (2002) (129)
- Role of hydrazine in isoniazid-induced hepatotoxicity in a hepatocyte inflammation model. (2008) (128)
- Rapid ventricular pacing of dogs to heart failure: biochemical and physiological studies. (1990) (123)
- Caffeic acid, chlorogenic acid, and dihydrocaffeic acid metabolism: glutathione conjugate formation. (2001) (122)
- A conceptual framework for predicting the toxicity of reactive chemicals: modeling soft electrophilicity (2006) (121)
- Molecular cytotoxic mechanisms of anticancer hydroxychalcones. (2004) (121)
- Prooxidant and antioxidant activity of vitamin E analogues and troglitazone. (2005) (118)
- 1-bromoalkanes as new potent nontoxic glutathione depletors in isolated rat hepatocytes. (1991) (115)
- Endogenous and endobiotic induced reactive oxygen species formation by isolated hepatocytes. (2002) (112)
- Microsomal electron transport. I. Reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase and cytochrome P-450 as electron carriers in microsomal NADPH-peroxidase activity. (1973) (106)
- Repeated acetaminophen dosing in rats: adaptation of hepatic antioxidant system (2000) (101)
- Further studies on lipid-peroxide formation in isolated hepatocytes. (1975) (99)
- Human and animal hepatocytes in vitro with extrapolation in vivo. (2004) (96)
- Hydroperoxide dependent O-dealkylation reactions catalyzed by liver microsomal cytochrome P450. (1975) (96)
- Quantitative structure toxicity relationships for phenols in isolated rat hepatocytes. (2003) (93)
- Effects of phosphodiesterase 3,4,5 inhibitors on hepatocyte cAMP levels, glycogenolysis, gluconeogenesis and suceptibility to a mitochondrial toxin (2003) (92)
- Toxicity of glyoxals--role of oxidative stress, metabolic detoxification and thiamine deficiency. (2003) (90)
- Cytochrome P-450 as a microsomal peroxidase in steroid hydroperoxide reduction. (1972) (90)
- Intracellular mechanisms for the decomposition of a lipid peroxide. II. Decomposition of a lipid peroxide by subcellular fractions. (1969) (87)
- High Content Analysis Provides Mechanistic Insights on the Pathways of Toxicity Induced by Amine-Modified Polystyrene Nanoparticles (2014) (87)
- Fructose and carbonyl metabolites as endogenous toxins. (2009) (86)
- The effects of heme-binding proteins on the peroxidative and catalatic activities of hemin. (1999) (86)
- Modulating hypoxia-induced hepatocyte injury by affecting intracellular redox state. (1995) (85)
- Mechanism of sulfite cytotoxicity in isolated rat hepatocytes. (2008) (85)
- Possible higher valence states of cytochrome P-450 during oxidative reactions. (1974) (85)
- Catechin metabolism: glutathione conjugate formation catalyzed by tyrosinase, peroxidase, and cytochrome p450. (2001) (84)
- Fully-automated spectrophotometric method for measurement of antioxidant activity of catalase. (2000) (79)
- Compensatory downregulation of myocardial Ca channel in SR from dogs with heart failure. (1993) (78)
- Oxidative Stress Mediated Idiosyncratic Drug Toxicity (2005) (78)
- Coenzyme Q Cytoprotective Mechanisms for Mitochondrial Complex I Cytopathies Involves NAD(P)H: Quinone Oxidoreductase 1(NQO1) (2002) (77)
- High-content analysis in toxicology: screening substances for human toxicity potential, elucidating subcellular mechanisms and in vivo use as translational safety biomarkers. (2014) (75)
- Application of quantitative structure-toxicity relationships for the comparison of the cytotoxicity of 14 p-benzoquinone congeners in primary cultured rat hepatocytes versus PC12 cells. (2004) (74)
- Comparative quantitative structure toxicity relationships for flavonoids evaluated in isolated rat hepatocytes and HeLa tumor cells. (2002) (73)
- Oxygen activation during peroxidase catalysed metabolism of flavones or flavanones. (1999) (72)
- Prevention of hydrogen sulfide (H2S)-induced mouse lethality and cytotoxicity by hydroxocobalamin (vitamin B(12a)). (2007) (72)
- Mitochondrial involvement in genetically determined transition metal toxicity I. Iron toxicity. (2006) (72)
- Peroxidases: a role in the metabolism and side effects of drugs. (2005) (71)
- Mechanisms of H2O2 formation by leukocytes. Evidence for a plasma membrane location. (1975) (71)
- Peroxidase-mediated irreversible binding of arylamine carcinogens to DNA in intact polymorphonuclear leukocytes activated by a tumor promoter. (1985) (70)
- The role of the skeletal muscle ryanodine receptor gene in malignant hyperthermia. (1992) (69)
- Biochemical and functional disturbances in red blood cells of herring gulls ingesting Prudhoe Bay crude oil. (1985) (69)
- Involvement of cytochrome P-450 in the intracellular formation of lipid peroxides. (1975) (67)
- Lysosomal involvement in hepatocyte cytotoxicity induced by Cu(2+) but not Cd(2+). (2001) (67)
- The effects of antioxidants on the metabolism and mutagenicity of benzo[a]pyrene in vitro. (1977) (67)
- Molecular mechanisms of chloroacetaldehyde-induced cytotoxicity in isolated rat hepatocytes. (1993) (66)
- Reductive metabolism of nitroprusside in rat hepatocytes and human erythrocytes. (1991) (66)
- The effectiveness of a lipid peroxide in oxidizing protein and non-protein thiols. (1968) (66)
- The possible involvement of a peroxidase in prostaglandin biosynthesis. (1976) (64)
- Metabolism of caffeic acid by isolated rat hepatocytes and subcellular fractions. (2002) (63)
- The possible involvement of singlet oxygen in prostaglandin biosynthesis. (1976) (61)
- Catalase Activity Assays (2006) (61)
- Simultaneous Detection of the Antioxidant and Pro-oxidant Activity of Dietary Polyphenolics in a Peroxidase System (2003) (60)
- The consequences of lipid peroxidation in isolated hepatocytes. (1975) (59)
- Hybrid quantum dot-fatty ester stealth nanoparticles: toward clinically relevant in vivo optical imaging of deep tissue. (2011) (58)
- Methotrexate induced mitochondrial injury and cytochrome c release in rat liver hepatocytes (2018) (57)
- Singlet oxygen formation during hemoprotein catalyzed lipid peroxide decomposition. (1977) (57)
- High content analysis of cytotoxic effects of pDMAEMA on human intestinal epithelial and monocyte cultures. (2010) (55)
- Enzyme-generated electronically excited carbonyl compounds, Acetone phosphorescence during the peroxidase-catalyzed aerobic oxidation of isobutanal. (1978) (55)
- Hepatocyte injury resulting from the inhibition of mitochondrial respiration at low oxygen concentrations involves reductive stress and oxygen activation. (1995) (54)
- Differential reactivity of cardiac and skeletal muscle from various species in two generations of cardiac troponin-T immunoassays. (1998) (54)
- Effects of ingestion of hibernia and Prudhoe Bay crude oils on hepatic and renal mixed function oxidase in nestling herring gulls (Larus argentatus). (1985) (53)
- Protective effects of ferulic acid and related polyphenols against glyoxal- or methylglyoxal-induced cytotoxicity and oxidative stress in isolated rat hepatocytes. (2015) (53)
- The cellular localisation of glutathione peroxidase and its release from mitochondria during swelling. (1970) (52)
- Blood cardiac troponin in toxic myocardial injury: archetype of a translational safety biomarker (2006) (52)
- Mitochondrial involvement in genetically determined transition metal toxicity II. Copper toxicity. (2006) (52)
- Prevention of cyanide-induced cytotoxicity by nutrients in isolated rat hepatocytes. (1994) (51)
- The peroxidase nature of cytochrome P-420 utilizing a lipid peroxide substrate. (1971) (51)
- Metabolism, not autoxidation, plays a role in α-oxoaldehyde- and reducing sugar-induced erythrocyte GSH depletion: Relevance for diabetes mellitus (2003) (51)
- Products of oxidation of a protein thiol group after reaction with various oxidizing agents. (1967) (51)
- Bioactivation of fluorotelomer alcohols in isolated rat hepatocytes. (2009) (51)
- Compartmentation of enzymes in the rat liver mitochondrial matrix. (1975) (51)
- Structure–activity relationships for thiol reactivity and rat or human hepatocyte toxicity induced by substituted p‐benzoquinone compounds (2008) (51)
- A comparison of hepatocyte cytotoxic mechanisms for chromate and arsenite. (2005) (50)
- Oxygen stores and aerobic dive limit of ringed seals (Phoca hispida) (1992) (49)
- Quinone toxicity in hepatocytes: studies on mitochondrial Ca2+ release induced by benzoquinone derivatives. (1987) (49)
- Hepatocyte toxicity of mechlorethamine and other alkylating anticancer drugs. Role of lipid peroxidation. (1992) (48)
- Quantitative structure toxicity relationships for catechols in isolated rat hepatocytes. (2004) (48)
- Structure–activity relationships for hepatocyte toxicity and electrophilic reactivity of α,β‐unsaturated esters, acrylates and methacrylates (2008) (47)
- Free-radical-mediated DNA binding. (1985) (46)
- Myocardial myoglobin deficiency in various animal models of congestive heart failure. (1992) (46)
- The involvement of semidehydroascorbate reductase in the oxidation of NADH by lipid peroxide in mitochondria and microsomes. (1973) (45)
- Prooxidant activity of free radicals derived from phenol-containing neurotransmitters. (2002) (45)
- Involvement of nitric oxide in nitroprusside-induced hepatocyte cytotoxicity. (1996) (45)
- Cytoprotective mechanisms of carbonyl scavenging drugs in isolated rat hepatocytes. (2009) (44)
- Serum cardiac troponin I concentrations in dogs with leishmaniasis: correlation with age and clinicopathologic abnormalities. (2012) (44)
- Metabolic mechanisms of methanol/formaldehyde in isolated rat hepatocytes: carbonyl-metabolizing enzymes versus oxidative stress. (2011) (44)
- Acrolein and chloroacetaldehyde: an examination of the cell and cell-free biomarkers of toxicity. (2013) (44)
- Use of a DNA-based test for the mutation associated with porcine stress syndrome (malignant hyperthermia) in 10,000 breeding swine. (1993) (44)
- Peroxidase catalysed oxygen activation by arylamine carcinogens and phenol. (1985) (44)
- Peroxidase catalysed formation of cytotoxic prooxidant phenothiazine free radicals at physiological pH. (2004) (43)
- Allyl alcohol- and acrolein-induced toxicity in isolated rat hepatocytes. (1989) (43)
- 2-Chloroacetaldehyde-induced cerebral glutathione depletion and neurotoxicity. (1996) (43)
- Structure-activity relationships for halobenzene induced cytotoxicity in rat and human hepatoctyes (2007) (43)
- Peroxidaze Catalyzed singlet oxygen formation from hydrogen peroxide (1977) (42)
- N-OXIDATION OF AROMATIC AMINES BY INTRACELLULAR OXIDASES (2002) (42)
- Preventing cell death induced by carbonyl stress, oxidative stress or mitochondrial toxins with vitamin B anti-AGE agents. (2008) (41)
- Menadione (2-methyl-1,4-naphthoquinone)-induced Ca2+ release from rat-liver mitochondria is caused by NAD(P)H oxidation. (1986) (41)
- Amodiaquine-induced oxidative stress in a hepatocyte inflammation model. (2009) (41)
- Differences in glyoxal and methylglyoxal metabolism determine cellular susceptibility to protein carbonylation and cytotoxicity. (2011) (41)
- Properties of rat liver mitochondria with intermembrane Cytochrome c. (1976) (41)
- Singlet oxygen formation by a peroxidase, H2O2 and halide system. (1979) (41)
- Application of quantitative structure-toxicity relationships for acute NSAID cytotoxicity in rat hepatocytes. (2005) (40)
- Respiratory chain defect of myocardial mitochondria in idiopathic dilated cardiomyopathy of Doberman pinscher dogs. (1992) (40)
- Nitrofurantoin-mediated oxidative stress cytotoxicity in isolated rat hepatocytes. (1988) (39)
- Evaluation of alamar blue reduction for the in vitro assay of hepatocyte toxicity. (1999) (39)
- Myocardial Ca(2+)- and ATP-cycling imbalances in end-stage dilated and ischemic cardiomyopathies. (1995) (38)
- Marginal dietary thiamin deficiency induces the formation of colonic aberrant crypt foci (ACF) in rats. (2003) (38)
- Rapid, simple and sensitive microassay for skeletal and cardiac muscle myoglobin and hemoglobin: use in various animals indicates functional role of myohemoproteins (1992) (38)
- Hepatocyte cytotoxicity induced by various hepatotoxins mediated by cytochrome P-450IIE1: protection with diethyldithiocarbamate administration. (1992) (38)
- Application of structure–activity relationships to investigate the molecular mechanisms of hepatocyte toxicity and electrophilic reactivity of α,β‐unsaturated aldehydes (2008) (38)
- The mechanism of action of cytochrome P-450. Occurrence of the 'NIH shift' during hydroperoxide-dependent aromatic hydroxylations. (1978) (38)
- Effect of diquat on the antioxidant system and cell growth in human neuroblastoma cells. (2002) (37)
- Hydroperoxides and superoxides in microsomal oxidations (1978) (37)
- Usefulness of transesophageal echocardiography in predicting mortality and morbidity in stroke patients without clinically known cardiac sources of embolus. (1998) (37)
- Catecholic iron complexes as cytoprotective superoxide scavengers against hypoxia:reoxygenation injury in isolated hepatocytes. (1998) (36)
- Canine malignant hyperthermia: diagnosis of susceptibility in a breeding colony. (1983) (36)
- Differential effects of antioxidants, steroids and other compounds on benzo(a)pyrene 3-hydroxylase activity in various tissues of rat. (1979) (35)
- Modulating carbonyl cytotoxicity in intact rat hepatocytes by inhibiting carbonyl metabolizing enzymes. II. Aromatic aldehydes. (2003) (35)
- Calcium sequestration by isolated sarcoplasmic reticulum: real-time monitoring using ratiometric dual-emission spectrofluorometry and the fluorescent calcium-binding dye indo-1 (1990) (35)
- The prevention of CCl4-induced liver necrosis in mice by naturally occurring methylenedioxybenzenes. (1996) (35)
- Deficiencies of myocardial troponin-T and creatine kinase MB isoenzyme in dogs with idiopathic dilated cardiomyopathy. (1997) (35)
- High-content analysis for drug delivery and nanoparticle applications. (2015) (34)
- Toxicity of nitrobenzene compounds towards isolated hepatocytes: dependence on reduction potential. (1990) (34)
- Porcine malignant hyperthermia susceptibility: erythrocytic osmotic fragility. (1985) (34)
- Herbal monoterpene alcohols inhibit propofol metabolism and prolong anesthesia time. (2006) (34)
- Blood volume increase in salt-induced pulmonary hypertension, heart failure and ascites in broiler and White Leghorn chickens. (1993) (33)
- Metabolic activation of 4-hydroxyanisole by isolated rat hepatocytes. (2002) (33)
- Toxicity of petroleum crude oils and their effect on xenobiotic metabolizing enzyme activities in the chicken embryo in ovo. (1986) (32)
- Chloroacetaldehyde-induced hepatocyte cytotoxicity. Mechanisms for cytoprotection. (1994) (32)
- The inactivation of isocitrate dehydrogenase by a lipid peroxide. (1971) (32)
- Biochemical transformation of canine skeletal muscle for use in cardiac-assist devices. (1990) (32)
- Hepatocyte susceptibility to glyoxal is dependent on cell thiamin content. (2007) (32)
- Changes in erythrocyte deformability in NaCl-induced right-sided cardiac failure in broiler chickens. (1992) (32)
- Phenol oxidation product(s), formed by a peroxidase reaction, that bind to DNA. (1985) (32)
- Role of sulfhydryl groups in benzoquinone-induced Ca2+ release by rat liver mitochondria. (1988) (32)
- The glutathione dependence of inorganic sulfate formation from L- or D-cysteine in isolated rat hepatocytes. (1998) (31)
- Molecular mechanisms of nitrofurantoin-induced hepatocyte toxicity in aerobic versus hypoxic conditions. (1993) (31)
- Oxidation of glutathione by free radical intermediates formed during peroxidase‐catalysed N‐demethylation reactions (1983) (31)
- Iron complexes of deferiprone and dietary plant catechols as cytoprotective superoxide radical scavengers(1). (2001) (31)
- Sulfation and glucuronidation of phenols: implications in coenyzme Q metabolism. (2005) (30)
- A head-to-head Caco-2 assay comparison of the mechanisms of action of the intestinal permeation enhancers: SNAC and sodium caprate (C10). (2020) (30)
- Sarcoplasmic reticulum Ca-release channel and ATP-synthesis activities are early myocardial markers of heart failure produced by rapid ventricular pacing in dogs. (1994) (30)
- The mycotoxin patulin increases colonic epithelial permeability in vitro. (2012) (30)
- Cytotoxic molecular mechanisms and cytoprotection by enzymic metabolism or autoxidation for glyceraldehyde, hydroxypyruvate and glycolaldehyde. (2011) (29)
- The molecular mechanisms of diallyl disulfide and diallyl sulfide induced hepatocyte cytotoxicity. (2009) (29)
- Accelerated cytotoxicity mechanism screening using drug metabolising enzyme modulators. (2005) (29)
- The Association between Glyceraldehyde-Derived Advanced Glycation End-Products and Colorectal Cancer Risk (2015) (29)
- [43] A peroxidase assay for cytochrome P-450 (1978) (28)
- Glutathione oxidation during peroxidase catalysed drug metabolism. (1987) (28)
- Lysosomal oxidative stress cytotoxicity induced by nitrofurantoin redox cycling in hepatocytes. (2001) (28)
- Glyoxal markedly compromises hepatocyte resistance to hydrogen peroxide. (2006) (28)
- Hydrogen peroxide supports human and rat cytochrome P450 1A2-catalyzed 2-amino-3-methylimidazo[4,5-f]quinoline bioactivation to mutagenic metabolites: significance of cytochrome P450 peroxygenase. (1997) (28)
- The role of cytochrome P-450 in the hydroperoxide-catalyzed oxidation of alcohols by rat-liver microsomes. (1977) (28)
- Molecular mechanism for prevention of N-acetyl-p-benzoquinoneimine cytotoxicity by the permeable thiol drugs diethyldithiocarbamate and dithiothreitol. (1991) (27)
- CHAPTER 9 – Multiple Mechanisms of Metabolic Activation of Aromatic Amine Carcinogens (1984) (27)
- High content analysis to determine cytotoxicity of the antimicrobial peptide, melittin and selected structural analogs (2011) (27)
- Flutamide-Induced Cytotoxicity and Oxidative Stress in an In Vitro Rat Hepatocyte System (2014) (27)
- Cytoprotection by almond skin extracts or catechins of hepatocyte cytotoxicity induced by hydroperoxide (oxidative stress model) versus glyoxal or methylglyoxal (carbonylation model). (2010) (26)
- Drug‐Associated Mitochondrial Toxicity (2008) (26)
- Cytotoxicity induced by N-methyl-N'-nitro-N-nitrosoguanidine may involve S-nitrosyl glutathione and nitric oxide. (1995) (26)
- The effects of partial thiamin deficiency and oxidative stress (i.e., glyoxal and methylglyoxal) on the levels of α‐oxoaldehyde plasma protein adducts in Fischer 344 rats (2005) (25)
- Hepatocyte cytotoxicity induced by hydroperoxide (oxidative stress model) or glyoxal (carbonylation model): prevention by bioactive nut extracts or catechins. (2009) (25)
- Evaluation of Azathioprine-Induced Cytotoxicity in an In Vitro Rat Hepatocyte System (2014) (25)
- Effects of asbestos on membrane transport and metabolism of benzo(a)pyrene. (1980) (25)
- Peroxidase-catalyzed benzidine binding to DNA and other macromolecules. (1985) (25)
- A-CD estrogens. I. Substituent effects, hormone potency, and receptor subtype selectivity in a new family of flexible estrogenic compounds. (2011) (24)
- Myeloperoxidase catalysed cooxidative metabolism of methimazole: oxidation of glutathione and NADH by free radical intermediates. (1990) (24)
- Metabolic activation of 3-hydroxyanisole by isolated rat hepatocytes. (2003) (24)
- Mechanisms of hydrogen peroxide formation in leukocytes: the NAD(P)H oxidase activity of myeloperoxidase. (1975) (24)
- Porcine malignant hyperthermia susceptibility: hypersensitive calcium-release mechanism of skeletal muscle sarcoplasmic reticulum. (1986) (24)
- Effect of a high omega-3 fatty acid diet on cardiac contractile performance in Oncorhynchus mykiss. (1996) (24)
- Prevention of nitrofurantoin-induced cytotoxicity in isolated hepatocytes by fructose. (1991) (24)
- Antidotal effect of dihydroxyacetone against cyanide toxicity in vivo. (1996) (24)
- Canine malignant hyperthermia susceptibility: erythrocytic defects--osmotic fragility, glucose-6-phosphate dehydrogenase deficiency and abnormal Ca2+ homeostasis. (1984) (24)
- Hydroxyl-radical formation during prostaglandin formation catalysed by prostaglandin cyclo-oxygenase [proceedings]. (1978) (23)
- Mechanisms of H2O2 formation by leukocytes. Properties of the NAD(P)H oxidase activity of intact leukocytes. (1975) (23)
- The prevention of ferric nitrilotriacetate-induced nephro- and hepatotoxicity by methylenedioxybenzene antioxidants. (1997) (23)
- Diaziquone-induced cytotoxicity in isolated rat hepatocytes. (1989) (22)
- Superoxide radical scavenging and attenuation of hypoxia-reoxygenation injury by neurotransmitter ferric complexes in isolated rat hepatocytes (2000) (22)
- Rapid and specific efflux of glutathione before hepatocyte injury induced by hypoxia. (1997) (22)
- Myocardial Ca-sequestration failure and compensatory increase in Ca-ATPase with congestive cardiomyopathy: kinetic characterization by a homogenate microassay using real-time ratiometric indo-1 spectrofluorometry (1991) (22)
- Malignant hyperthermia susceptibility: biochemical basis for pathogenesis and diagnosis. (1990) (22)
- Hepatocyte-catalysed detoxification of cyanide by L- and D-cysteine. (1998) (22)
- Antioxidants and cancer: molecular mechanisms. (1994) (21)
- Porcine malignant hyperthermia susceptibility: increased calcium-sequestering activity of skeletal muscle sarcoplasmic reticulum. (1986) (21)
- Prooxidant activity and cytotoxic effects of indole-3-acetic acid derivative radicals. (2004) (21)
- Rescuing hepatocytes from iron-catalyzed oxidative stress using vitamins B1 and B6. (2011) (21)
- Molecular mechanisms of SR 4233-induced hepatocyte toxicity under aerobic versus hypoxic conditions. (1993) (21)
- Lipid and steroid hydroperoxides as substrates for the non-selenium-dependent glutathione peroxidase. (1979) (21)
- Compensatory asymmetry in down-regulation and inhibition of the myocardial Ca2+ cycle in congestive heart failure produced in dogs by idiopathic dilated cardiomyopathy and rapid ventricular pacing. (1994) (21)
- Cytotoxicity and mechanism of action of a new ROS-generating microsphere formulation for circumventing multidrug resistance in breast cancer cells (2010) (21)
- Modulating carbonyl cytotoxicity in intact rat hepatocytes by inhibiting carbonyl-metabolizing enzymes. I. Aliphatic alkenals. (2003) (20)
- Molecular cytotoxic mechanisms of catecholic polychlorinated biphenyl metabolites in isolated rat hepatocytes. (2007) (20)
- Cytoprotective and anticancer properties of coenzyme Q versus capsaicin (2003) (20)
- Canine stress syndrome/malignant hyperthermia susceptibility: calcium-homeostasis defect in muscle and lymphocytes. (1990) (20)
- Quantitative structure-toxicity relationships by accelerated cytotoxicity mechanism screening. (2004) (19)
- Translation of novel anti-cancer cytotoxicity biomarkers detected with high content analysis from an in vitro predictive model to an in vivo cell model. (2010) (19)
- Cytochrome P450 peroxidase/peroxygenase mediated xenobiotic metabolic activation and cytotoxicity in isolated hepatocytes. (1995) (19)
- A thermolyzed diet increases oxidative stress, plasma alpha-aldehydes and colonic inflammation in the rat. (2007) (19)
- Validation of a Multiparametric, High-Content-Screening Assay for Predictive/Investigative Cytotoxicity: Evidence from Technology Transfer Studies and Literature Review. (2017) (19)
- Peroxidase-catalysed binding of [U-14C]phenol to DNA. (1985) (19)
- S-nitrosyl glutathione-mediated hepatocyte cytotoxicity. (1993) (18)
- Correlation of serum cardiac troponin I and acute phase protein concentrations with clinical staging in dogs with degenerative mitral valve disease. (2015) (18)
- Cytochrome P450 2E1 metabolically activates propargyl alcohol: propiolaldehyde-induced hepatocyte cytotoxicity. (2001) (18)
- Effects of hypocaloric feeding and refeeding on myocardial Ca and ATP cycling in the rat (1995) (18)
- Hepatocyte or serum albumin protein carbonylation by oxidized fructose metabolites: Glyceraldehyde or glycolaldehyde as endogenous toxins? (2010) (18)
- Hydroxyl radical involvement in the luminol chemiluminescence from the reaction of arachidonic acid with sheep vesicular gland microsomes. (1980) (18)
- Effectiveness of a Prudhoe Bay crude oil and its aliphatic, aromatic and heterocyclic fractions in inducing mortality and aryl hydrocarbon hydroxylase in chick embryo in ovo (1987) (18)
- Adenosine 3′ : 5′-Cyclic Monophosphate Stimulation of Calcium Efflux from Mitochondria (1974) (18)
- Chemical carcinogenesis, mutagenesis, and teratogenesis. (1996) (17)
- Oxygen activation during drug metabolism. (1987) (17)
- Proton release associated with respiratory burst of polymorphonuclear leukocytes. (1988) (17)
- Effects of prolonged low frequency stimulation on skeletal muscle sarcoplasmic reticulum. (1995) (17)
- Accelerated cytotoxic mechanism screening of hydralazine using an in vitro hepatocyte inflammatory cell peroxidase model. (2008) (17)
- Cardiac and muscle fatigue due to relative functional overload induced by excessive stimulation, hypersensitive excitation-contraction coupling, or diminished performance capacity correlates with sarcoplasmic reticulum failure. (1991) (17)
- Coenzyme Q cytoprotective mechanisms. (2004) (16)
- Phenylenediamine induced hepatocyte cytotoxicity redox. Cycling mediated oxidative stress without oxygen activation. (1997) (16)
- THE INVOLVEMENT OF 1 O2 IN THE INACTIVATION OF MIXED FUNCTION OXIDASE AND PEROXIDATION OF MEMBRANE LIPIDS DURING THE PHOTOSENSITIZED OXIDATION OF LIVER MICROSOMES (1978) (16)
- Generation of activated oxygen species by polymorphonuclear leukocytes (1980) (16)
- Hepatocyte inflammation model for cytotoxicity research: fructose or glycolaldehyde as a source of endogenous toxins (2009) (16)
- Differential expression of the lenticular antioxidant system in laboratory animals: A determinant of species predilection to oxidative stress-induced ocular toxicity? (2003) (16)
- Myocardial biochemical changes in furazolidone-induced cardiomyopathy of turkeys. (1990) (16)
- PEROXIDE-MEDIATED METABOLIC ACTIVATION OF CARCINOGENS (1982) (16)
- Myocardial calcium cycling defect in furazolidone cardiomyopathy. (1991) (15)
- Molecular mechanisms of dibromoalkane cytotoxicity in isolated rat hepatocytes. (1993) (15)
- The involvement of cytochrome P450 peroxidase in the metabolic bioactivation of cumene hydroperoxide by isolated rat hepatocytes. (1996) (15)
- Modifications of Mitochondrial Function by Toxicants (2010) (15)
- Molecular cytotoxic mechanisms of chlorpromazine in isolated rat hepatocytes. (2013) (14)
- Serial analysis of serum cardiac troponin I changes and correlation with clinical findings in 46 dogs with mitral valve disease. (2014) (14)
- Glyoxal and methylglyoxal: autoxidation from dihydroxyacetone and polyphenol cytoprotective antioxidant mechanisms. (2013) (14)
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