Peter K. Sorger
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Peter K. Sorgerphysics Degrees
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Peter K. Sorgerphilosophy Degrees
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Peter K. Sorger's Degrees
- Doctorate Medicine Harvard University
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(Suggest an Edit or Addition)Peter K. Sorger's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq (2016) (2825)
- Cells on chips (2006) (2005)
- Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis (2009) (982)
- MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells (2001) (789)
- Yeast heat shock factor is an essential DNA-binding protein that exhibits temperature-dependent phosphorylation (1988) (782)
- SARS-CoV-2 infection protects against rechallenge in rhesus macaques (2020) (779)
- Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks (2012) (614)
- Physicochemical modelling of cell signalling pathways (2006) (610)
- A role for the Adenomatous Polyposis Coli protein in chromosome segregation (2001) (592)
- Heat shock factor and the heat shock response (1991) (590)
- Chromosome Missegregation and Apoptosis in Mice Lacking the Mitotic Checkpoint Protein Mad2 (2000) (566)
- A Systems Model of Signaling Identifies a Molecular Basis Set for Cytokine-Induced Apoptosis (2005) (536)
- Systems biology and combination therapy in the quest for clinical efficacy (2006) (533)
- Timing and checkpoints in the regulation of mitotic progression. (2004) (512)
- Towards a Rigorous Assessment of Systems Biology Models: The DREAM3 Challenges (2010) (432)
- Input–output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data (2009) (420)
- Electronic detection of DNA by its intrinsic molecular charge (2002) (417)
- Heat shock factor is regulated differently in yeast and HeLa cells (1987) (405)
- Growth rate inhibition metrics correct for confounders in measuring sensitivity to cancer drugs (2016) (392)
- Quantitative analysis of pathways controlling extrinsic apoptosis in single cells. (2008) (386)
- Combination Cancer Therapy Can Confer Benefit via Patient-to-Patient Variability without Drug Additivity or Synergy (2017) (376)
- Trimerization of a yeast transcriptional activator via a coiled-coil motif (1989) (373)
- Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities (2007) (365)
- Discrete logic modelling as a means to link protein signalling networks with functional analysis of mammalian signal transduction (2009) (365)
- Highly multiplexed imaging of single cells using a high-throughput cyclic immunofluorescence method (2015) (358)
- Logic-Based Models for the Analysis of Cell Signaling Networks† (2010) (338)
- Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes (2018) (328)
- Measuring and Modeling Apoptosis in Single Cells (2011) (313)
- Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes. (2003) (312)
- Purification and characterization of a heat‐shock element binding protein from yeast. (1987) (308)
- The yeast DASH complex forms closed rings on microtubules (2005) (307)
- Discovery of potent and selective covalent inhibitors of JNK. (2012) (298)
- The Open Microscopy Environment (OME) Data Model and XML file: open tools for informatics and quantitative analysis in biological imaging (2005) (294)
- Modeling a Snap-Action, Variable-Delay Switch Controlling Extrinsic Cell Death (2008) (290)
- Transient Sister Chromatid Separation and Elastic Deformation of Chromosomes during Mitosis in Budding Yeast (2000) (289)
- Phylogenetic and structural analysis of centromeric DNA and kinetochore proteins (2006) (288)
- Classic and contemporary approaches to modeling biochemical reactions. (2010) (286)
- S-phase feedback control in budding yeast independent of tyrosine phosphorylation of P34cdc28 (1992) (285)
- Molecular Analysis of Kinetochore-Microtubule Attachment in Budding Yeast (2001) (281)
- A Noncanonical Frizzled2 Pathway Regulates Epithelial-Mesenchymal Transition and Metastasis (2014) (280)
- Molecular organization of the Ndc80 complex, an essential kinetochore component. (2005) (267)
- The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations. (2017) (267)
- Metrics other than potency reveal systematic variation in responses to cancer drugs. (2013) (260)
- Informatics and Quantitative Analysis in Biological Imaging (2003) (259)
- Yeast heat shock factor contains separable transient and sustained response transcriptional activators (1990) (255)
- LINCS Canvas Browser: interactive web app to query, browse and interrogate LINCS L1000 gene expression signatures (2014) (240)
- Coupling cell division and cell death to microtubule dynamics. (1997) (237)
- Structure, function, and regulation of budding yeast kinetochores. (2003) (236)
- The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution (2020) (234)
- Profiling receptor tyrosine kinase activation by using Ab microarrays (2003) (225)
- Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity (2020) (224)
- A dual role for Bub1 in the spindle checkpoint and chromosome congression (2005) (223)
- Programming biological models in Python using PySB (2013) (220)
- BID preferentially activates BAK while BIM preferentially activates BAX, affecting chemotherapy response. (2013) (211)
- Identification of essential components of the S. cerevisiae kinetochore (1993) (211)
- The Response of Human Epithelial Cells to TNF Involves an Inducible Autocrine Cascade (2006) (209)
- Spindle checkpoint proteins and chromosome–microtubule attachment in budding yeast (2004) (205)
- L1000CDS2: LINCS L1000 characteristic direction signatures search engine (2016) (200)
- The Logic of EGFR/ErbB Signaling: Theoretical Properties and Analysis of High-Throughput Data (2009) (199)
- Genetic selection of peptide inhibitors of biological pathways. (1999) (194)
- Non-genetic cell-to-cell variability and the consequences for pharmacology. (2009) (194)
- Structure and assembly of turnip crinkle virus. II. Mechanism of reassembly in vitro. (1986) (190)
- Chromosome segregation and genomic stability. (2004) (185)
- A single-cell landscape of high-grade serous ovarian cancer (2020) (184)
- Cloning and expression of a gene encoding hsc73, the major hsp70‐like protein in unstressed rat cells. (1987) (179)
- Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo (2013) (175)
- Discovering causal pathways linking genomic events to transcriptional states using Tied Diffusion Through Interacting Events (TieDIE) (2013) (175)
- Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1‐ or APC‐depleted cells (2006) (174)
- A Compendium of Signals and Responses Triggered by Prodeath and Prosurvival Cytokines*S (2005) (173)
- Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de‐differentiated state (2017) (173)
- Fuzzy Logic Analysis of Kinase Pathway Crosstalk in TNF/EGF/Insulin-Induced Signaling (2007) (167)
- Regulating the Yeast Kinetochore by Ubiquitin-Dependent Degradation and Skp1p-Mediated Phosphorylation (1997) (160)
- Regulation of Saccharomyces cerevisiae kinetochores by the type 1 phosphatase Glc7p. (1999) (158)
- Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques (2020) (149)
- Comparing signaling networks between normal and transformed hepatocytes using discrete logical models. (2011) (149)
- Training Signaling Pathway Maps to Biochemical Data with Constrained Fuzzy Logic: Quantitative Analysis of Liver Cell Responses to Inflammatory Stimuli (2011) (145)
- Crowdsourcing Network Inference: The DREAM Predictive Signaling Network Challenge (2011) (143)
- Analysis of mitosis and antimitotic drug responses in tumors by in vivo microscopy and single-cell pharmacodynamics. (2011) (142)
- The glucose-regulated protein grp94 is related to heat shock protein hsp90. (1987) (139)
- Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer (2020) (139)
- Bayesian Network Approach to Cell Signaling Pathway Modeling (2002) (138)
- Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity. (2009) (133)
- Analysis of kinesin motor function at budding yeast kinetochores (2006) (132)
- Rapid phospho-turnover by receptor tyrosine kinases impacts downstream signaling and drug binding. (2011) (127)
- Fractional killing arises from cell-to-cell variability in overcoming a caspase activity threshold (2015) (125)
- From word models to executable models of signaling networks using automated assembly (2017) (121)
- Surviving apoptosis: life-death signaling in single cells. (2015) (121)
- Changing Mad2 Levels Affects Chromosome Segregation and Spindle Assembly Checkpoint Control in Female Mouse Meiosis I (2007) (120)
- Generating chromosome instability through the simultaneous deletion of Mad2 and p53. (2005) (119)
- Image metrics in the statistical analysis of DNA microarray data (2001) (117)
- Cue-Signal-Response Analysis of TNF-Induced Apoptosis by Partial Least Squares Regression of Dynamic Multivariate Data (2004) (117)
- Networks Inferred from Biochemical Data Reveal Profound Differences in Toll-like Receptor and Inflammatory Signaling between Normal and Transformed Hepatocytes* (2010) (113)
- The Unstable F-box Protein p58-Ctf13 Forms the Structural Core of the CBF3 Kinetochore Complex (1999) (111)
- Mps1 at kinetochores is essential for female mouse meiosis I (2011) (110)
- Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity. (2019) (108)
- Retention of the BUB3 checkpoint protein on lagging chromosomes. (1999) (108)
- Cyclic Immunofluorescence (CycIF), A Highly Multiplexed Method for Single‐cell Imaging (2016) (103)
- Collecting and organizing systematic sets of protein data (2006) (102)
- Fundamental trade-offs between information flow in single cells and cellular populations (2017) (101)
- Conservation of protein abundance patterns reveals the regulatory architecture of the EGFR-MAPK pathway (2016) (101)
- A High-throughput Quantitative Multiplex Kinase Assay for Monitoring Information Flow in Signaling Networks (2003) (101)
- Factors required for the binding of reassembled yeast kinetochores to microtubules in vitro (1994) (100)
- A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling (2007) (100)
- Kinome-wide Selectivity Profiling of ATP-competitive Mammalian Target of Rapamycin (mTOR) Inhibitors and Characterization of Their Binding Kinetics* (2012) (99)
- Profiles of Basal and Stimulated Receptor Signaling Networks Predict Drug Response in Breast Cancer Lines (2013) (96)
- Structure of a central component of the yeast kinetochore: the Spc24p/Spc25p globular domain. (2006) (96)
- Cell stimulus and lysis in a microfluidic device with segmented gas-liquid flow. (2005) (92)
- Structure and function of kinetochores in budding yeast. (1995) (90)
- Structural and functional dissection of Mif2p, a conserved DNA-binding kinetochore protein. (2008) (89)
- Targeting immunosuppressive macrophages overcomes PARP inhibitor resistance in BRCA1-associated triple-negative breast cancer (2020) (88)
- Cells surviving fractional killing by TRAIL exhibit transient but sustainable resistance and inflammatory phenotypes (2013) (88)
- Properties of cell death models calibrated and compared using Bayesian approaches (2013) (86)
- The human kinetochore proteins Nnf1R and Mcm21R are required for accurate chromosome segregation (2006) (84)
- Probing the Architecture of a Simple Kinetochore Using DNA–Protein Crosslinking (1997) (84)
- Exploring the Contextual Sensitivity of Factors that Determine Cell-to-Cell Variability in Receptor-Mediated Apoptosis (2012) (84)
- Centromeric Chromatin and Epigenetic Effects in Kinetochore Assembly (1998) (83)
- Flexible informatics for linking experimental data to mathematical models via DataRail (2008) (81)
- Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype. (2019) (80)
- Creating and analyzing pathway and protein interaction compendia for modelling signal transduction networks (2012) (79)
- Adaptive informatics for multi-factorial and high content biological data (2011) (79)
- Direct Lyapunov exponent analysis enables parametric study of transient signalling governing cell behaviour. (2006) (79)
- Microfluidics closes in on point-of-care assays (2008) (78)
- Correction: Towards a Rigorous Assessment of Systems Biology Models: The DREAM3 Challenges (2010) (77)
- Systematic analysis of BRAFV600E melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis (2015) (75)
- Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress (2014) (75)
- Roles for the Conserved Spc105p/Kre28p Complex in Kinetochore-Microtubule Binding and the Spindle Assembly Checkpoint (2009) (74)
- Yeast kinetochore microtubule dynamics analyzed by high-resolution three-dimensional microscopy. (2005) (72)
- A Multi-center Study on the Reproducibility of Drug-Response Assays in Mammalian Cell Lines (2019) (71)
- Profiling phospho-signaling networks in breast cancer using reverse-phase protein arrays (2013) (69)
- Intra- and Interdimeric Caspase-8 Self-Cleavage Controls Strength and Timing of CD95-Induced Apoptosis (2014) (67)
- Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma (2020) (67)
- Lyapunov exponents and phase diagrams reveal multi-factorial control over TRAIL-induced apoptosis (2011) (65)
- Cytokine-associated drug toxicity in human hepatocytes is associated with signaling network dysregulation. (2010) (63)
- Impaired SHP2-mediated extracellular signal-regulated kinase activation contributes to gefitinib sensitivity of lung cancer cells with epidermal growth factor receptor-activating mutations. (2010) (62)
- Qualifying antibodies for image-based immune profiling and multiplexed tissue imaging (2019) (62)
- p31comet acts to ensure timely spindle checkpoint silencing subsequent to kinetochore attachment (2011) (61)
- Machine learning identifies candidates for drug repurposing in Alzheimer’s disease (2021) (61)
- Dissecting Variability in Responses to Cancer Chemotherapy Through Systems Pharmacology (2010) (60)
- Studying chromosome instability in the mouse. (2008) (58)
- A multiscale statistical mechanical framework integrates biophysical and genomic data to assemble cancer networks (2014) (58)
- Alternative drug sensitivity metrics improve preclinical cancer pharmacogenomics (2017) (58)
- A reductionist's systems biology: opinion. (2005) (56)
- Binding of the essential Saccharomyces cerevisiae kinetochore protein Ndc10p to CDEII. (2003) (55)
- HSF1 phase transition mediates stress adaptation and cell fate decisions (2019) (55)
- Development and Characterization of a Wee1 Kinase Degrader. (2019) (54)
- MCMICRO: a scalable, modular image-processing pipeline for multiplexed tissue imaging (2021) (53)
- Profiling drugs for rheumatoid arthritis that inhibit synovial fibroblast activation (2016) (53)
- Spindle checkpoint deficiency is tolerated by murine epidermal cells but not hair follicle stem cells (2013) (52)
- Common and cell-type specific responses to anti-cancer drugs revealed by high throughput transcript profiling (2017) (51)
- A curative combination cancer therapy achieves high fractional cell killing through low cross-resistance and drug additivity (2019) (51)
- Multiplexed immunofluorescence reveals potential PD-1/PD-L1 pathway vulnerabilities in craniopharyngioma (2018) (51)
- GRcalculator: an online tool for calculating and mining dose–response data (2017) (50)
- Single-sequence protein structure prediction using a language model and deep learning (2022) (50)
- BIOPHYSICAL PREDICTION OF PROTEIN-PEPTIDE INTERACTIONS AND SIGNALING NETWORKS USING MACHINE LEARNING (2019) (48)
- Two genes required for the binding of an essential Saccharomyces cerevisiae kinetochore complex to DNA. (1995) (48)
- Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma (2017) (48)
- Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism (2020) (47)
- Systematic calibration of a cell signaling network model (2010) (46)
- Mps1 at kinetochores is essential for female mouse meiosis I (2011) (46)
- Kinetochores distinguish GTP from GDP forms of the microtubule lattice (1997) (45)
- New approaches to modeling complex biochemistry (2011) (44)
- Single-sequence protein structure prediction using language models from deep learning (2021) (44)
- Receptor-Driven ERK Pulses Reconfigure MAPK Signaling and Enable Persistence of Drug-Adapted BRAF-Mutant Melanoma Cells. (2020) (43)
- Real-time imaging of the dynamics of death receptors and therapeutics that overcome TRAIL resistance in tumors (2013) (43)
- Report on EU–USA Workshop: How Systems Biology Can Advance Cancer Research (27 October 2008) (2009) (43)
- Adaptation of Human iPSC-Derived Cardiomyocytes to Tyrosine Kinase Inhibitors Reduces Acute Cardiotoxicity via Metabolic Reprogramming. (2019) (43)
- The Dark Kinase Knowledgebase: an online compendium of knowledge and experimental results of understudied kinases (2020) (43)
- Discovery and resistance mechanism of a selective CDK12 degrader (2021) (42)
- Cheminformatics Tools for Analyzing and Designing Optimized Small-Molecule Collections and Libraries. (2019) (42)
- Live cell imaging of yeast. (2011) (40)
- Analysis of growth factor signaling in genetically diverse breast cancer lines (2014) (38)
- The Spatial Landscape of Progression and Immunoediting in Primary Melanoma at Single-Cell Resolution (2021) (38)
- Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma (2021) (37)
- Evolution of delayed resistance to immunotherapy in a melanoma responder (2021) (37)
- Encoding Growth Factor Identity in the Temporal Dynamics of FOXO3 under the Combinatorial Control of ERK and AKT Kinases. (2018) (35)
- A reductionist’s systems biology (2005) (35)
- Mismatch repair deficiency in high-grade meningioma: a rare but recurrent event associated with dramatic immune activation and clinical response to PD-1 blockade. (2018) (34)
- Recombination and lineage-specific mutations linked to the emergence of SARS-CoV-2 (2020) (34)
- Mass spectrometry based method to increase throughput for kinome analyses using ATP probes. (2013) (34)
- Phosphotyrosine Signaling Proteins that Drive Oncogenesis Tend to be Highly Interconnected* (2013) (33)
- Myeloid antigen-presenting cell niches sustain antitumor T cells and license PD-1 blockade via CD28 costimulation. (2021) (33)
- Leveraging Compound Promiscuity to Identify Targetable Cysteines within the Kinome. (2019) (31)
- Facetto: Combining Unsupervised and Supervised Learning for Hierarchical Phenotype Analysis in Multi-Channel Image Data (2019) (31)
- Highly multiplexed immunofluorescence images and single-cell data of immune markers in tonsil and lung cancer (2019) (31)
- Exceptional response and multisystem autoimmune-like toxicities associated with the same T cell clone in a patient with uveal melanoma treated with immune checkpoint inhibitors (2019) (31)
- S. cerevisiae Chromosomes Biorient via Gradual Resolution of Syntely between S Phase and Anaphase (2013) (30)
- Development of CDK2 and CDK5 Dual Degrader TMX-2172. (2020) (30)
- Quantification of sensitivity and resistance of breast cancer cell lines to anti-cancer drugs using GR metrics (2017) (29)
- Tracing the pathway of spindle assembly checkpoint signaling. (2001) (29)
- A dynamic view of the proteomic landscape during differentiation of ReNcell VM cells, an immortalized human neural progenitor line (2019) (27)
- Personal Protective Equipment for COVID-19: Distributed Fabrication and Additive Manufacturing. (2020) (27)
- Measuring Cancer Drug Sensitivity and Resistance in Cultured Cells (2017) (27)
- Regulatory and Safety Considerations in Deploying a Locally Fabricated, Reusable Face Shield in a Hospital Responding to the COVID-19 Pandemic (2020) (27)
- Multiplexed Exchange-PAINT imaging reveals ligand-dependent EGFR and Met interactions in the plasma membrane (2017) (27)
- Inflammatory but not mitogenic contexts prime synovial fibroblasts for compensatory signaling responses to p38 inhibition (2018) (27)
- FamPlex: a resource for entity recognition and relationship resolution of human protein families and complexes in biomedical text mining (2018) (27)
- Differentiable biology: using deep learning for biophysics-based and data-driven modeling of molecular mechanisms (2021) (26)
- Chromosome movement: Kinetochores motor along (1998) (26)
- Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3 (2018) (26)
- GeneWalk identifies relevant gene functions for a biological context using network representation learning (2019) (25)
- Independent Drug Action in Combination Therapy: Implications for Precision Oncology (2022) (25)
- Quantitative microscopy of green fluorescent protein-labeled yeast. (2002) (24)
- Predictable Clinical Benefits without Evidence of Synergy in Trials of Combination Therapies with Immune-Checkpoint Inhibitors (2022) (24)
- OpenFold: Retraining AlphaFold2 yields new insights into its learning mechanisms and capacity for generalization (2022) (24)
- Modulating cell-to-cell variability and sensitivity to death ligands by co-drugging (2013) (23)
- A Dual Array-Based Approach to Assess the Abundance and Posttranslational Modification State of Signaling Proteins (2012) (23)
- Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells. (2019) (22)
- Multiplexed 3D atlas of state transitions and immune interaction in colorectal cancer (2021) (22)
- MITI minimum information guidelines for highly multiplexed tissue images (2021) (22)
- Protein structure prediction by AlphaFold2: are attention and symmetries all you need? (2021) (22)
- Response and Mechanisms of Resistance to Larotrectinib and Selitrectinib in Metastatic Undifferentiated Sarcoma Harboring Oncogenic Fusion of NTRK1 (2020) (22)
- Structure-guided development of covalent TAK1 inhibitors. (2017) (21)
- Comparative autoregressive moving average analysis of kinetochore microtubule dynamics in yeast. (2006) (21)
- Analysis of SteraMist ionized hydrogen peroxide technology in the sterilization of N95 respirators and other PPE (2021) (21)
- Oncometabolite d-2HG alters T cell metabolism to impair CD8+ T cell function (2022) (20)
- An expanding role for cell biologists in drug discovery and pharmacology (2012) (20)
- Analysis of SteraMist ionized hydrogen peroxide technology in the sterilization of N95 respirators and other PPE: a quality improvement study (2020) (20)
- Crystal structure of the yeast inner kinetochore subunit Cep3p. (2007) (20)
- Snapshots of Protein Dynamics and Post-translational Modifications In One Experiment—β-Catenin and Its Functions* (2011) (20)
- Designing Drug‐Response Experiments and Quantifying their Results (2017) (19)
- INDRA-IPM: interactive pathway modeling using natural language with automated assembly (2019) (19)
- Stitching and registering highly multiplexed whole-slide images of tissues and tumors using ASHLAR (2021) (19)
- Clinical Efficacy and Molecular Response Correlates of the WEE1 Inhibitor Adavosertib Combined with Cisplatin in Patients with Metastatic Triple-Negative Breast Cancer (2020) (18)
- A High Content Screen in Macrophages Identifies Small Molecule Modulators of STING-IRF3 and NFkB Signaling. (2018) (17)
- Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity. (2019) (17)
- Fibroblast–tumor cell signaling limits HER2 kinase therapy response via activation of MTOR and antiapoptotic pathways (2020) (17)
- Inhibition of Haspin kinase promotes cell-intrinsic and extrinsic anti-tumor activity. (2019) (17)
- Chemical Biology Toolkit for DCLK1 Reveals Connection to RNA Processing. (2020) (16)
- Receptor-based mechanism of relative sensing and cell memory in mammalian signaling networks (2020) (16)
- Failure analysis of clinical trials to test the amyloid hypothesis (2014) (15)
- Temporal and spatial topography of cell proliferation in cancer (2021) (14)
- Clathrin cubes: an extreme variant of the normal cage (1986) (14)
- 3D Printed frames to enable reuse and improve the fit of N95 and KN95 respirators (2020) (14)
- Drug independence and the curability of cancer by combination chemotherapy. (2022) (14)
- Assessing the quality of nontraditional N95 filtering face-piece respirators available during the COVID-19 pandemic (2020) (14)
- Cell biology: The more MAD, the merrier (2005) (14)
- Genome-encoded cytoplasmic double-stranded RNAs, found in C9ORF72 ALS-FTD brain, propagate neuronal loss (2021) (14)
- Studies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors. (2017) (14)
- Decision-Tree Based Model Analysis for Efficient Identification of Parameter Relations Leading to Different Signaling States (2013) (13)
- Abstract 1063: Benefit from combination cancer therapy arising from patient-to-patient variability rather than additive or synergistic drug action (2017) (13)
- UnMICST: Deep learning with real augmentation for robust segmentation of highly multiplexed images of human tissues (2021) (13)
- Structure-based design of a potent and selective covalent inhibitor for SRC kinase that targets a p-Loop cysteine. (2020) (13)
- Minerva: a light-weight, narrative image browser for multiplexed tissue images (2020) (12)
- A Data-Driven Computational Model of the ErbB Receptor Signaling Network (2006) (12)
- A human breast atlas integrating single-cell proteomics and transcriptomics. (2022) (11)
- Single-cell tumor-immune microenvironment of BRCA1/2 mutated high-grade serous ovarian cancer (2021) (11)
- Rapid prototyping and clinical testing of a reusable face shield for health care workers responding to the COVID-19 pandemic (2020) (11)
- Online narrative guides for illuminating tissue atlas data and digital pathology images (2020) (11)
- Inferring reaction network structure from single-cell, multiplex data, using toric systems theory (2019) (11)
- Interpretative guides for interacting with tissue atlas and digital pathology data using the Minerva browser (2020) (10)
- Combinatorial benefit without synergy in recent clinical trials of immune checkpoint inhibitors (2020) (10)
- Heterogeneity and Clonal Evolution of Acquired PARP Inhibitor Resistance in TP53- and BRCA1-Deficient Cells (2021) (10)
- Molecular structures and interactions in the yeast kinetochore. (2010) (10)
- A multitargeted probe-based strategy to identify signaling vulnerabilities in cancers (2019) (9)
- Oncogenic pathways impinging on the G2-restriction point (2008) (9)
- Reproducibility will only come with data liberation (2016) (9)
- Fides: Reliable trust-region optimization for parameter estimation of ordinary differential equation models (2021) (9)
- HAND1 and BARX1 Act as Transcriptional and Anatomic Determinants of Malignancy in Gastrointestinal Stromal Tumor (2021) (9)
- Phenotypic clustering of yeast mutants based on kinetochore microtubule dynamics (2007) (9)
- Cancer patient survival can be parametrized to improve trial precision and reveal time-dependent therapeutic effects (2022) (9)
- Assessing the filtration efficiency and regulatory status of N95s and nontraditional filtering face-piece respirators available during the COVID-19 pandemic (2021) (8)
- Elevated GM-CSF and IL-1beta levels compromise the ability of p38 MAPK inhibitors to modulate TNFalpha levels in the human monocytic/macrophage U937 cell line. (2010) (8)
- Narrative online guides for the interpretation of digital-pathology images and tissue-atlas data (2021) (8)
- A simple open-source method for highly multiplexed imaging of single cells in tissues and tumours (2017) (8)
- Three-dimensional spatial transcriptomics uncovers cell type localizations in the human rheumatoid arthritis synovium (2022) (8)
- A Proof of Concept for Biomarker-Guided Targeted Therapy against Ovarian Cancer Based on Patient-Derived Tumor Xenografts (2020) (8)
- A Crisis-Responsive Framework for Medical Device Development Applied to the COVID-19 Pandemic (2021) (8)
- Integrating multi-omics data reveals function and therapeutic potential of deubiquitinating enzymes (2021) (8)
- Exploring the understudied human kinome for research and therapeutic opportunities (2020) (7)
- Mitotic checkpoints, genetic instability, and cancer. (2000) (7)
- Genome-Encoded Cytoplasmic Double-Stranded RNAs, Found in C9ORF72 ALS-FTD Brain, Provoke Propagated Neuronal Death (2018) (7)
- Systematic analysis of BRAFV 600 E melanomas reveals a role for JNK / c-Jun pathway in adaptive resistance to drug-induced apoptosis (2015) (7)
- Time-resolved phosphoproteomics reveals scaffolding and catalysis-responsive patterns of SHP2-dependent signaling (2021) (7)
- Single cell spatial analysis reveals the topology of immunomodulatory purinergic signaling in glioblastoma (2022) (7)
- Sporadic ERK pulses drive non-genetic resistance in drug-adapted BRAFV600E melanoma cells (2019) (7)
- Receptor-Based Mechanism of Cell Memory and Relative Sensing in Mammalian Signaling Networks (2017) (6)
- Maintaining the provenance of microscopy metadata using OMERO.forms software (2017) (6)
- 3D Printed frames to enable reuse and improve the fit of N95 and KN95 respirators (2021) (6)
- Cheminformatics Tools for Analyzing and Designing Optimized Small Molecule Collections and Libraries (2018) (6)
- Targeting TBK1 to overcome resistance to cancer immunotherapy (2022) (5)
- The human kinetochore proteins Nnf1R and Mcm21R are required for accurate chromosome segregation (2009) (5)
- Assembling a corpus of phosphoproteomic annotations using ProtMapper to normalize site information from databases and text mining (2019) (5)
- Three-dimensional spatial transcriptomics uncovers cell type dynamics in the rheumatoid arthritis synovium (2020) (5)
- SYLARAS: A Platform for the Statistical Analysis and Visual Display of Systemic Immunoprofiling Data and Its Application to Glioblastoma (2020) (5)
- Author Correction: Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer (2020) (5)
- Drugs in a curative combination therapy for lymphoma exhibit low cross-resistance but not pharmacological synergy (2018) (4)
- Comparing the Efficacy of Cancer Therapies between Subgroups in Basket Trials (2018) (4)
- Micro-region transcriptomics of fixed human tissue using Pick-Seq (2021) (4)
- Recombination and lineage-specific mutations linked to the emergence of SARS-CoV-2 (2021) (4)
- Multi-omics profiling establishes the polypharmacology of FDA Approved CDK4/6 inhibitors and its impact on drug response (2018) (4)
- A multi-omic analysis of MCF10A cells provides a resource for integrative assessment of ligand-mediated molecular and phenotypic responses (2022) (4)
- Channel Embedding for Informative Protein Identification from Highly Multiplexed Images (2020) (4)
- Automated assembly of molecular mechanisms at scale from text mining and curated databases (2022) (4)
- A LINCS microenvironment perturbation resource for integrative assessment of ligand-mediated molecular and phenotypic responses (2021) (4)
- Cheminformatics tools for analyzing and designing optimized small molecule libraries (2018) (4)
- Scope2Screen: Focus+Context Techniques for Pathology Tumor Assessment in Multivariate Image Data (2021) (3)
- Deletion of the MAD 2 L 1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma (2017) (3)
- Multiplexed and reproducible high content screening of live and fixed cells using the Dye Drop method (2021) (3)
- Elevated GM-CSF and IL-1 b levels compromise the ability of p 38 MAPK inhibitors to modulate TNF a levels in the human monocytic / macrophage U 937 cell line (2010) (3)
- A curative combination therapy for lymphomas achieves high fractional cell killing through low cross-resistance and drug additivity but not synergy (2019) (3)
- De novo Powered Air-Purifying Respirator Design and Fabrication for Pandemic Response (2021) (3)
- Mechanistic model of MAPK signaling reveals how allostery and rewiring contribute to drug resistance (2022) (3)
- In vitro assays for studying Saccharomyces cerevisiae kinetochore activity. (1999) (3)
- Visinity: Visual Spatial Neighborhood Analysis for Multiplexed Tissue Imaging Data (2022) (3)
- Multiplexed proteomics and imaging of resolving and lethal SARS-CoV-2 infection in the lung (2020) (3)
- Spatial intra-tumor heterogeneity is associated with survival of lung adenocarcinoma patients (2022) (2)
- Therapeutically advantageous secondary targets of abemaciclib identified by multi-omics profiling of CDK4/6 inhibitors (2017) (2)
- Clinical efficacy and molecular response correlates of the WEE1 inhibitor adavosertib combined with cisplatin in patients with metastatic triple-negative breast cancer (mTNBC) (2021) (2)
- Systemic Lymphoid Architecture Response Assessment (SYLARAS): An approach to multi-organ, discovery-based immunophenotyping implicates a role for CD45R/B220+ CD8T cells in glioblastoma immunology (2019) (2)
- Data Descriptor: Proteomic profiling across breast cancer cell lines and models (2020) (2)
- THE OPEN MICROSCOPY ENVIRONMENT MATLAB HANDLER : COMBINING A BIOINFORMATICS DATA & IMAGE REPOSITORY WITH A QUANTITATIVE ANALYSIS ENVIRONMENT (2005) (2)
- CRAN-11. MULTIPLEXED IMMUNOFLUORESCENCE REVEALS POTENTIAL PD-1/PD-L1 PATHWAY VULNERABILITIES IN CRANIOPHARYNGIOMA (2018) (2)
- Qualifying antibodies for image-based immune profiling and multiplexed tissue imaging (2019) (2)
- Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer (2020) (2)
- Overview Towards a Rigorous Assessment of Systems Biology Models : The DREAM 3 Challenges (2010) (2)
- Adaptation of human iPSC-derived cardiomyocytes to tyrosine kinase inhibitors reduces acute cardiotoxicity via metabolic reprogramming (2018) (2)
- Time resolved quantitative phosphoproteomics reveals distinct patterns of SHP2 dependence in EGFR signaling (2019) (2)
- Single-cell tumor-immune microenvironment of BRCA1/2 mutated high-grade serous ovarian cancer (2022) (2)
- DeepDyeDrop: an image-based approach to quantify the phenotypic response of cancer cells to therapeutics (Conference Presentation) (2018) (2)
- De Novo Powered Air-Purifying Respirator Design and Fabrication for Pandemic Response (2021) (2)
- MICROFLUIDIC DEVICES FOR STUDYING THE RESPONSE OF ADHERENT CELLS UNDER SHORT TIME STIMULI TREATMENT (2007) (2)
- The effect of patient-to-patient variability in drug response on combination cancer therapies, from 1961 to today. (2018) (2)
- Multi-modal digital pathology for colorectal cancer diagnosis by high-plex immunofluorescence imaging and traditional histology of the same tissue section (2023) (2)
- A Crisis-Responsive Framework for Medical Device Development during the COVID-19 Pandemic (2020) (2)
- Regulation of yeast Saccharomyces cerevisiae kinetochores by the type 1 phosphatase Glc7p (1998) (1)
- Abstract PR5: The receptor tyrosine kinase layer of breast cancer cell lines is predictive of the response to therapeutic drugs (2012) (1)
- Abstract 482: Rapid highly multiplexed immunoprofiling of human fixed tissues by Orion imaging (2021) (1)
- Abstract PD4-02: Advantageous polypharmacology of abemaciclib revealed by omics profiling of CDK4/6 inhibitors (2018) (1)
- Abstract 788: Transcriptional landscape of drug response guides the design of potent and synergistic drug combinations (2016) (1)
- Abstract 2131: Curating cartography: Enabling the harmonisation, visualisation, and reuse of diverse multiplexed imaging data through the Human Tumor Atlas Network Data Coordinating Center (2022) (1)
- Abstract 5213: A systems biology approach to understanding differential phenotypic outcome of BRAF(V600E) inhibition in melanoma cells. (2013) (1)
- Predictable clinical benefits without synergy in trials of combination therapies with immune checkpoint inhibitors (2021) (1)
- Opposing immune and genetic forces shape oncogenic programs in synovial sarcoma (2019) (1)
- IMMU-09. CONCURRENT DEXAMETHASONE LIMITS THE CLINICAL BENEFIT OF IMMUNE CHECKPOINT BLOCKADE IN GLIOBLASTOMA (2020) (1)
- Abstract 203: Single cell imaging of kinase inhibitor-induced effects in breast cancer cell lines (2016) (1)
- Abstract PS18-02: Highly multiplexed tissue-based cyclic immunofluorescence (t-CyCIF) for precision oncology identifies novel patterns of HER2 heterogeneity in breast cancer (2021) (1)
- Abstract PR16: Transcriptional landscape of drug response guides the design of specific and potent drug combinations (2015) (1)
- GeneWalk v1.3.0 Github repository (2021) (1)
- Overcoming differential tumor penetration of BRAF inhibitors using computationally guided combination therapy (2022) (1)
- Selectivity and binding kinetics of mTOR inhibitors 1 Kinome-wide selectivity profiling of ATP-competitive mTOR ( mammalian target of rapamycin ) inhibitors and characterization of their binding kinetics (2011) (1)
- Multiplexed and reproducible high content screening of live and fixed cells using Dye Drop (2022) (1)
- in one experiment - β-catenin and its functions (2011) (1)
- Abstract P4-04-06: Integrative analysis of single-cell transcriptomic and spatial profiles characterized distinct tumor microenvironment phenotypes in hormone receptor positive (HR+) breast cancer (2022) (1)
- Author response: Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes (2018) (1)
- Omics profiling of CDK4/6 inhibitors reveals functionally important secondary targets of abemaciclib (Conference Presentation) (2018) (1)
- 209 Preclinical mechanistic and clinical evaluation of the corticosteroid dexamethasone’s detrimental effects on immune checkpoint blockade in glioblastoma cancer (2020) (1)
- Machine Learning Identifies Novel Candidates for Drug Repurposing in Alzheimer’s Disease (2020) (1)
- A multi-center study on factors influencing the reproducibility of in vitro drug-response studies (2017) (1)
- Author response: A curative combination cancer therapy achieves high fractional cell killing through low cross-resistance and drug additivity (2019) (1)
- Abstract 5502: Metrics other than potency reveal systematic variation in responses to cancer drugs (2014) (1)
- FamPlex: a resource for entity recognition and relationship resolution of human protein families and complexes in biomedical text mining (2018) (1)
- Author Correction: Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer (2020) (0)
- Abstract PO-072: Control of inter- and intra-patient cancer heterogeneity is a predictively accurate explanation for the success of many combination therapies for solid and hematological cancers (2020) (0)
- Using Optimal Transformations and Multi-Experiment Fitting to Detect and Reduce Effects of Non-Identifiable Parameters in Non-Linear Dynamical Models (2009) (0)
- Abstract B103: Torin2 and related analogs exploit replicative and checkpoint vulnerabilities to induce death of triple-negative breast cancer cells (2019) (0)
- Abstract 2068: A highly selective dual Haspin-kinase and PIM-inhibitor overcomes RAF/MEK-inhibitor resistance in melanoma (2019) (0)
- A dynamic view of the proteomic landscape during differentiation of ReNcell VM cells, an immortalized human neural progenitor line (2019) (0)
- Abstract C14: Modeling the dynamics of caspase 8 activity after TRAIL stimulation reveals DISC features controlling cell fate in vitro (2013) (0)
- Abstract 3514: A genetic-metabolic circuit of liver-specific metastatic organotropism (2023) (0)
- Abstract B184: A novel analytical approach to accurately assess in vitro responses to targeted therapeutics (2015) (0)
- Abstract 2385: Systematic characterization of kinase inhibitors reveals heterogeneity in responses by class and cell line (2017) (0)
- HSF1 phase transition mediates stress adaptation and cell fate decisions (2020) (0)
- Modeling Extrinsic Apoptosis Regulatory Network Pathways Using A Rules-based Framework (2009) (0)
- Abstract B39: A novel analytical approach to accurately assess in vitro drug responses for breast cancer therapy (2016) (0)
- Abstract 5877: Intratumoral lymphocyte networks harbor TCF1+ PD1+ progenitor CD8 T cells in lung cancer (2023) (0)
- Abstract 5670: Systemic lymphoid architecture response assessment (SYLARAS): Application to system-wide immunophenotyping of glioblastoma (2018) (0)
- Abstract ES6-2: Cell to Cell Variability in the Responses of Tumor Cells to Death Ligands and Other Anti-Cancer Drugs (2010) (0)
- Abstract 1678: A flow-based immunoprofiling strategy for interrogating system-wide leukocyte composition in response to glioblastoma (2017) (0)
- Introduction Live Cell Imaging of Yeast (2011) (0)
- Multi range ERK responses shape the proliferative trajectory of single cells following oncogene induced senescence (2022) (0)
- Cancer patient survival can be accurately parameterized, revealing time-dependent therapeutic effects and doubling the precision of small trials (2021) (0)
- Abstract 4487: Association of the tumor-immune microenvironment with response to niraparib and pembrolizumab in relapsed, platinum-resistant ovarian cancer (2019) (0)
- MULTIVARIATE APPROACHES FOR REVEALING BIOLOGICAL SIGNAL‐RESPONSE RELATIONSHIPS RELEVANT TO SEPSIS: 9 (2004) (0)
- Drug adaptation influences cardiotoxicity caused by tyrosine kinase inhibitors in iPSC-derived human cardiomyocytes (2018) (0)
- Comparison of Frontline Breast Cancer Drugs Reveals Important Differences (2019) (0)
- The impact of stage-related features in melanoma recurrence prediction: A machine learning approach (2022) (0)
- Cancer-associated Bax point mutations block apoptotic pore formation by trapping kinetic intermediates (2019) (0)
- Antibody Incubation Dye Bleaching Nuclear Staining Imaging n Channels Registration & Stitching Image Segmentation Feature Extraction Facetto Analysis (2019) (0)
- Abstract IA05: New methods and better theory for pre-clinical cancer pharmacogenomics (2017) (0)
- Abstract AP22: DNA DAMAGE RESPONSES AND IMMUNE PROFILING THROUGH HIGHLY MULTIPLEXED TISSUE IMMUNOFLUORESCENCE (T-CYCIF) IN HIGH-GRADE SEROUS OVARIAN CANCER (2019) (0)
- Abstract B21: Probing tumor heterogeneity and immune infiltration with Cyclic Immunofluorescence (CycIF), a robust, multiplexed imaging method (2017) (0)
- Biomarker-guided treatment strategies for ovarian cancer identified from a heterogeneous panel of patient-derived tumor xenografts (2020) (0)
- Immune Profiling of Dermatologic Adverse Events from Checkpoint Blockade using Tissue Cyclic Immunofluorescence (2023) (0)
- INNV-13. ALLELE: A CONSORTIUM FOR PROSPECTIVE GENOMICS AND FUNCTIONAL DIAGNOSTICS TO GUIDE PATIENT CARE AND TRIAL ANALYSIS IN NEWLY-DIAGNOSED GLIOBLASTOMA (2018) (0)
- Studies of TAK 1-centered polypharmacology with novel covalent TAK 1 inhibitors (2017) (0)
- Abstract P4-06-09: Pick-Seq®: Multi-parameter imaging combined with RNA sequencing of tissue section micro-regions for spatial analysis in breast carcinoma (2020) (0)
- Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism (2020) (0)
- Abstract SY19-01: Cell to cell variability in the responses of tumor cells to death ligands (2010) (0)
- Abstract P4-08-02: Integration of transcriptomic, proteomic and drug response data in triple negative breast cancer cell lines and PDX models (2017) (0)
- Abstract 489: Multi-parameter tissue section imaging and retrieval of image-defined micro-regions for RNA sequencing using the RareCyte® platform (2019) (0)
- Understanding and Tracking Pro- and Anti-Apoptotic BCL-2 protein Interactions and their Relation to Cancer in Extrinsic Apoptosis (2011) (0)
- TAMI-45. PHENOGENOMIC CHARACTERIZATION OF IMMUNOMODULATORY PURINERGIC SIGNALING IN GLIOBLASTOMA (2020) (0)
- 3D multiplexed tissue imaging reconstruction and optimized region-of-interest (ROI) selection through deep learning model of channels embedding (2022) (0)
- Abstract 6130: Cancer sensitivity to therapy is constrained by apoptosis regulation in cells of origin (2023) (0)
- A CRISPRi/a screening platform to study cellular nutrient transport in diverse microenvironments (2023) (0)
- Multi-range ERK responses shape the proliferative trajectory of single cells following oncogene induction (2023) (0)
- Impaired SHP 2-Mediated Extracellular Signal-Regulated Kinase Activation Contributes to Gefitinib Sensitivity of Lung Cancer Cells with Epidermal Factor Receptor-Citation (2010) (0)
- Abstract P5-04-01: PARP inhibition modulates the infiltration, phenotype and function of tumor-associated macrophages (TAMs) in BRCA-associated breast cancer and can be augmented by harnessing the anti-tumor potential of TAMs (2020) (0)
- Abstract 122: Highly multiplexed, spatially-resolved tissue imaging of genetically engineered mouse models of cancer to discover and characterize immune regulators of tumorigenesis (2021) (0)
- A Programmatic Modeling Approach to Explore Alternative Hypothesis of Mitochondrial Regulation in Extrinsic Apoptosis Signaling (2013) (0)
- Paired evaluation defines performance landscapes for machine learning models (2022) (0)
- FFPE Tissue Pre-treatment Before t-CyCIF on Leica Bond RX v2 (2019) (0)
- Abstract A105: PARP inhibition modulates the infiltration, phenotype, and function of tumor-associated macrophages (TAMs) in BRCA-associated breast cancer and can be augmented by harnessing the antitumor potential of TAMs (2020) (0)
- Abstract 1047: Combinatorial benefit without synergy in recent clinical trials of immune checkpoint inhibitors (2020) (0)
- Posttranslational Modification State of Signaling Proteins A Dual Array-Based Approach to Assess the Abundance and ` (2012) (0)
- 860 Targeting immunosuppressive macrophages overcomes PARP-inhibitor resistance in BRCA1-associated triple-negative breast cancer (2020) (0)
- Abstract LB-B09: ERK pulses drive non-genetic resistance in drug-adapted BRAFV600Emelanoma cells (2019) (0)
- Aneuploidy as a driver of liver cancer (2015) (0)
- Abstract 1816: Phenogenomic characterization of immunomodulatory purinergic signaling in glioblastoma (2021) (0)
- Abstract 1222: Developing kinase inhibitors with polypharmacological profiles for the treatment of resistant cancers (2017) (0)
- Abstract 3744: Single-cell analysis of adaptive resistance and fractional responses of melanoma cells to RAF/MEK inhibition (2015) (0)
- Implementation of single-cell genomics as a translational tool in patients with metastatic melanoma. (2016) (0)
- Publisher Correction: Single-sequence protein structure prediction using a language model and deep learning (2022) (0)
- Abstract 1705: Slide-based multi-parametric immunophenotyping of human blood samples by cyclic immunofluorescence using the Accucyte-CyteFinder system (2017) (0)
- Lymphocyte networks are dynamic cellular communities in the immunoregulatory landscape of lung adenocarcinoma (2022) (0)
- Author response: Time-resolved phosphoproteomics reveals scaffolding and catalysis-responsive patterns of SHP2-dependent signaling (2021) (0)
- Molecular Logic of Cellular Signaling (2011) (0)
- Targeting Vulnerabilities in Successive Cell Cycle Stages to Induce Death of PI3K-Activated Basal-Like Breast Cancer Cells (2018) (0)
- Abstract 1713: BAX and BAK are preferentially activated by BIM and BID, respectively, affecting clinical chemotherapy response. (2013) (0)
- Modeling pro-death signaling pathways in cancer hepatocytes using multi-combinatorial treatments of inhibitors and stimuli (2008) (0)
- Conversion of Existing UVB Phototherapy Units to UVC Germicidal Chambers for N95 Decontamination: Lessons Learned. (2021) (0)
- A Web-based Software Resource for Interactive Analysis of Multiplex Tissue Imaging Datasets (2022) (0)
- Abstract 139: DNA damage and immunoprofiling with highly multiplexed tissue immunofluorescence (t-CycIF) in high-grade serous ovarian cancer (2018) (0)
- Author response: Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma (2017) (0)
- Encoding growth factor identity in the temporal dynamics of FoxO3 under combinatorial regulation by ERK and Akt (2018) (0)
- Abstract A297: Microtubule targeting antimitotic drugs induce a lower mitotic arrest than clinically less effective antimitotic Eg5 inhibitors in mouse xenografts. (2013) (0)
- Systemic immune response profiling with SYLARAS implicates a role for CD45R/B220+ CD8+ T cells in glioblastoma immunology (2019) (0)
- Abstract 47: A clinically curative combination therapy acts by low cross-resistance between drugs, not by synergistic interactions between drugs (2017) (0)
- Tissue Cyclic Immunofluorescence (t-CyCIF) v2 (2020) (0)
- Biophysical prediction of protein–peptide interactions and signaling networks using machine learning (2020) (0)
- Abstract LB056: The spatial landscape of progression and immunoediting in primary melanoma at single cell resolution (2022) (0)
- Analysis of growth factor signaling in genetically diverse breast cancer lines (2014) (0)
- REPRESENTING BIOCHEMICAL NETWORKS WITH LOGIC-BASED MODELS What Is a Logic-Based Model ? (2010) (0)
- Abstract A082: Single-cell RNA-sequencing of metastatic melanoma identifies a cancer cell-intrinsic program associated with immune checkpoint inhibitor resistance (2019) (0)
- Selectivity and binding kinetics of mTOR inhibitors 2 (2011) (0)
- Open Access METHODOLOGY ARTICLE (2010) (0)
- Phosphopeptide mapping of caspase 9 by affinity capture mass spectrometry (1998) (0)
- Abstract P2-07-13: High-dimensional, single-cell analysis and transcriptional profiling reveal novel correlatives of response to PARP inhibition plus PD-1 blockade in triple-negative breast cancer (2022) (0)
- Development of a Selective CDK 7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype Graphical (2019) (0)
- Abstract B20: Transcriptional landscape of drug response guides the design of specific and potent drug combinations (2015) (0)
- Abstract 5037: New concepts for quantifying the benefits of mono and combination therapy in an era of big data (2017) (0)
- Abstract P6-07-33: Metrics of drug sensitivity based on growth rate inhibition correct for the confounding effects of variable division rates (2017) (0)
- Dimerization Domain of Mif2p (2008) (0)
- CLINICAL CANCER RESEARCH | TRANSLATIONAL CANCER MECHANISMS AND THERAPY PredictableClinical Benefitswithout Evidenceof Synergy in Trials of Combination Therapies with Immune-Checkpoint Inhibitors (2021) (0)
- Abstract B132: Inhibition of Haspin kinase to promote cell-intrinsic and extrinsic anticancer therapy (2019) (0)
- Multiplexed Exchange-PAINT imaging reveals ligand-dependent EGFR and Met interactions in the plasma membrane (2017) (0)
- Combined inhibition of mTOR and PIKKs exploits replicative and checkpoint vulnerabilities to induce death of PI3K-activated triple-negative breast cancer cells (2019) (0)
- IMPAIRED SHP2-MEDIATED ERK ACTIVATION CONTRIBUTES TO GEFITINIB SENSITIVITY OF LUNG CANCER CELLS WITH EGFR-ACTIVATING MUTATIONS (2010) (0)
- Abstract B60: Omics profiling of CDK4/6 inhibitors reveals functionally important secondary targets of abemaciclib (2018) (0)
- GRcalculator: an online tool for calculating and mining dose–response data (2017) (0)
- Abstract 142: Exploiting replicative vulnerabilities to counter incomplete responses to PI3K/Akt/mTOR inhibition (2017) (0)
- Abstract 2747: Single-cell tumor-immune microenvironment of BRCA1/2 mutated high-grade serous ovarian cancer (2021) (0)
- Abstract 972: Improving pre-clinical cancer pharmacogenomics with novel drug sensitivity metrics based on growth rate inhibition (2017) (0)
- Cancer patient survival can be parametrized to improve trial precision and reveal time-dependent therapeutic effects (2022) (0)
- Biphasic JNK–Erk Signaling Separates Induction and Maintenance of Cell Senescence after DNA Damage (2022) (0)
- Abstract 5561: Single-cell analysis reveals an adaptive, transiently heritable, slowly-dividing, drug-resistant state inhibitable by drug combinations (2017) (0)
- Single Molecule Counting using STORM/PALM (2012) (0)
- Abstract PD1-12: Omics profiling of CDK4/6 inhibitors reveals functionally important secondary targets of abemaciclib (2018) (0)
- Nociceptor neuroimmune interactomes reveal cell type- and injury-specific inflammatory pain pathways (2023) (0)
- Abstract A028: Multi-modal digital pathology by sequential acquisition and joint analysis of highly multiplexed immunofluorescence and hematoxylin and eosin images (2022) (0)
- Abstract PR3: Considering alternate signaling mechanisms models in extrinsic apoptosis using programmatic modeling approaches (2012) (0)
- Bioentities: a resource for entity recognition and relationship resolution in biomedical text mining (2017) (0)
- Abstract SY45-04: Development of therapeutic strategies by resolving the tumor ecosystem (2019) (0)
- Abstract PR17: Single-cell analysis reveals an adaptive, slowly-dividing, de-differentiated, drug-resistant cell state selectively inhibitable by drug combinations (2017) (0)
- Abstract B62: Integrating highly-multiplexed imaging with multi-omics data to uncover immunologic vulnerabilities in high-grade serous ovarian cancer (2020) (0)
- Abstract 2168: A growth rate corrected metric for cytotoxic co-culture systems (2020) (0)
- Abstract P6-05-01: Basal and induced receptor profiles cluster cell lines into subtypes and predict drug response in a panel of breast cancer lines (2013) (0)
- Common and cell-type specific responses to anti-cancer drugs revealed by high throughput transcript profiling (2017) (0)
- Abstract 2140: Mesenchymal stromal cells expressing a PEAK1/Cripto axis sustain pro-survival NF-κB signaling in adjacent tumor cells to promote disease progression and therapy resistance (2018) (0)
- Author response: Receptor-based mechanism of relative sensing and cell memory in mammalian signaling networks (2019) (0)
- Abstract SY17-03: Inferring cell death networks from biochemical data (2011) (0)
- GeneWalk identifies relevant gene functions for a biological context using network representation learning (2021) (0)
- Abstract A9: Systemic immune response profiling with SYLARAS implicates a role for CD45R/B220+ CD8+ T cells in glioblastoma immunology (2020) (0)
- Abstract 700: Development of a second-generation TRAIL agonist and predictive biomarker profile for colorectal cancer (2019) (0)
- Abstract PR07: The strength of drug selection determines the maximum fitness cost of resistance mutations in culture and xenografts (2015) (0)
- Abstract P5-02-03: Highly multiplexed tissue-based cyclic immunofluorescence in breast cancer for precision oncology (2020) (0)
- Prediction of early-stage melanoma recurrence using clinical and histopathologic features (2022) (0)
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What Schools Are Affiliated With Peter K. Sorger?
Peter K. Sorger is affiliated with the following schools:
