Peter Karran
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Peter Karranchemistry Degrees
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Organic Chemistry
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Peter Karranbiology Degrees
Biology
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Molecular Biology
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Biochemistry
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Chemistry Biology
Peter Karran's Degrees
- PhD Biochemistry University of California, Berkeley
- Masters Chemistry Stanford University
- Bachelors Chemistry Stanford University
Why Is Peter Karran Influential?
(Suggest an Edit or Addition)Peter Karran's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Azathioprine and UVA Light Generate Mutagenic Oxidative DNA Damage (2005) (582)
- DNA double strand break repair in mammalian cells. (2000) (471)
- Thiopurines in current medical practice: molecular mechanisms and contributions to therapy-related cancer (2008) (408)
- Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage (1993) (374)
- DNA damage tolerance, mismatch repair and genome instability (1994) (308)
- Adaptive response to alkylating agents involves alteration in situ of O6-methylguanine residues in DNA (1979) (242)
- Induction of a DNA glycosylase for N-methylated purines is part of the adaptive response to alkylating agents (1982) (236)
- Mechanisms of tolerance to DNA damaging therapeutic drugs. (2001) (231)
- The Mammalian Mismatch Repair Pathway Removes DNA 8-oxodGMP Incorporated from the Oxidized dNTP Pool (2002) (228)
- Mismatch correction at O6-methylguanine residues in E. coli DNA (1982) (206)
- Inducible repair of O‐alkylated DNA pyrimidines in Escherichia coli. (1984) (197)
- DNA excision repair pathways. (1997) (186)
- Unmasking a killer: DNA O(6)-methylguanine and the cytotoxicity of methylating agents. (2000) (181)
- DNA mismatch binding defects, DNA damage tolerance, and mutator phenotypes in human colorectal carcinoma cell lines. (1995) (178)
- Self-destruction and tolerance in resistance of mammalian cells to alkylation damage. (1992) (174)
- Thiopurines, DNA damage, DNA repair and therapy-related cancer. (2006) (171)
- Defective DNA mismatch repair in acute myeloid leukemia/myelodysplastic syndrome after organ transplantation. (2004) (168)
- Treatment of post‐transplant premalignant skin disease: a randomized intrapatient comparative study of 5‐fluorouracil cream and topical photodynamic therapy (2007) (165)
- Vanillins--a novel family of DNA-PK inhibitors. (2003) (164)
- Selective recognition of a cisplatin-DNA adduct by human mismatch repair proteins. (1997) (163)
- Hypoxanthine in deoxyribonucleic acid: generation by heat-induced hydrolysis of adenine residues and release in free form by a deoxyribonucleic acid glycosylase from calf thymus. (1980) (156)
- The Oxidized Deoxynucleoside Triphosphate Pool Is a Significant Contributor to Genetic Instability in Mismatch Repair-Deficient Cells (2004) (142)
- Azathioprine treatment photosensitizes human skin to ultraviolet A radiation (2008) (139)
- Genetic steps in colorectal cancer (1994) (133)
- Differential human nucleotide excision repair of paired and mispaired cisplatin-DNA adducts. (1997) (133)
- Selection for β2-microglobulin mutation in mismatch repair-defective colorectal carcinomas (1996) (127)
- Spontaneous development of drug resistance: mismatch repair and p53 defects in resistance to cisplatin in human tumor cells (2000) (124)
- Escherichia coli mutants deficient in 3-methyladenine-DNA glycosylase. (1980) (118)
- O6-Methylguanine-DNA methyltransferase of human lymphoid cells: structural and kinetic properties and absence in repair-deficient cells. (1983) (115)
- DNA excision-repair deficiency of human peripheral blood lymphocytes treated with chemical carcinogens. (1976) (114)
- DNA mismatch binding and incision at modified guanine bases by extracts of mammalian cells: implications for tolerance to DNA methylation damage. (1994) (112)
- Genomic instability and tolerance to alkylating agents. (1996) (111)
- Repair of O-alkylpyrimidines in mammalian cells: a present consensus. (1988) (109)
- Novel DNA lesions generated by the interaction between therapeutic thiopurines and UVA light. (2007) (106)
- Protein oxidation, UVA and human DNA repair (2016) (106)
- Site-specific mutagenesis in vivo by single methylated or deaminated purine bases. (1986) (103)
- Microsatellite instability and DNA mismatch repair in human cancer. (1996) (95)
- Photoactivation of DNA thiobases as a potential novel therapeutic option (2001) (91)
- Epigenetic regulation of the MGMT and hMSH6 DNA repair genes in cells resistant to methylating agents. (2000) (87)
- Is the ability to repair damage to DNA related to the proliferative capacity of a cell? The rejoining of X-ray-produced strand breaks. (1973) (85)
- A mismatch recognition defect in colon carcinoma confers DNA microsatellite instability and a mutator phenotype. (1994) (84)
- cDNA cloning and chromosomal assignment of the human O6-methylguanine-DNA methyltransferase. cDNA expression in Escherichia coli and gene expression in human cells. (1990) (84)
- Reactive oxygen‐mediated damage to a human DNA replication and repair protein (2007) (82)
- Reversal of UVA Skin Photosensitivity and DNA Damage in Kidney Transplant Recipients by Replacing Azathioprine (2012) (82)
- Human mismatch repair, drug-induced DNA damage, and secondary cancer. (2003) (82)
- Processing in vitro of an abasic site reacted with methoxyamine: a new assay for the detection of abasic sites formed in vivo. (1991) (82)
- Complementation of sensitivity to alkylating agents in Escherichia coli and Chinese hamster ovary cells by expression of a cloned bacterial DNA repair gene. (1986) (79)
- Two modes of microsatellite instability in human cancer: differential connection of defective DNA mismatch repair to dinucleotide repeat instability (2005) (77)
- Oxidatively-generated damage to DNA and proteins mediated by photosensitized UVA☆ (2017) (77)
- Mismatch repair and response to DNA-damaging antitumour therapies. (2003) (76)
- UVA photosensitization of thiopurines and skin cancer in organ transplant recipients (2012) (72)
- Enzymatic excision of free hypoxanthine from polydeoxynucleotides and DNA containing deoxyinosine monophosphate residues. (1978) (72)
- Immune surveillance in colorectal carcinoma (1995) (69)
- Mismatch repair and differential sensitivity of mouse and human cells to methylating agents. (1999) (68)
- Oxidative Stress–Induced Protein Damage Inhibits DNA Repair and Determines Mutation Risk and Therapeutic Efficacy (2016) (67)
- Mismatch Repair Defects andO 6-Methylguanine-DNA Methyltransferase Expression in Acquired Resistance to Methylating Agents in Human Cells* (1997) (64)
- Multiple forms of DNA Damage Caused by UVA Photoactivation of DNA 6‐Thioguanine (2012) (62)
- O6-methylguanine residues elicit DNA repair synthesis by human cell extracts. (1993) (62)
- Reactive oxygen species generated by thiopurine/UVA cause irreparable transcription-blocking DNA lesions (2009) (61)
- 8-Oxoguanine incorporation into DNA repeats in vitro and mismatch recognition by MutSα (2005) (61)
- 4-thiothymidine sensitization of DNA to UVA offers potential for a novel photochemotherapy (2012) (59)
- Drug treatment in the development of mismatch repair defective acute leukemia and myelodysplastic syndrome. (2003) (58)
- PTCH mutations in basal cell carcinomas from azathioprine-treated organ transplant recipients (2008) (55)
- A biochemical defect in the repair of alkylated DNA in cells from an immunodeficient patient (46BR). (1983) (53)
- Guanine sulphinate is a major stable product of photochemical oxidation of DNA 6-thioguanine by UVA irradiation (2009) (52)
- The cytotoxic and mutagenic effects of alkylating agents on human lymphoid cells are caused by different DNA lesions. (1985) (51)
- Oxidative Damage to RPA Limits the Nucleotide Excision Repair Capacity of Human Cells. (2015) (51)
- Specificity of the bacteriophage PBS2 induced inhibitor of uracil-DNA glycosylase. (1981) (50)
- 8-Oxoguanine incorporation into DNA repeats in vitro and mismatch recognition by MutSα (2005) (50)
- Processing of O6-methylguanine by mismatch correction in human cell extracts (1996) (48)
- Protein oxidation and DNA repair inhibition by 6-thioguanine and UVA radiation. (2014) (47)
- Drug-related killings: a case of mistaken identity. (1996) (45)
- Efficient DNA interstrand crosslinking by 6-thioguanine and UVA radiation. (2011) (44)
- DNA mismatch repair and acquired cisplatin resistance in E. coli and human ovarian carcinoma cells. (2003) (41)
- Thiothymidine combined with UVA as a potential novel therapy for bladder cancer (2011) (40)
- Developmental decline in DNA repair in neural retina cells of chick embryos: persistent deficiency of repair competence in a cell line derived from late (1977) (40)
- Crosslinking of DNA repair and replication proteins to DNA in cells treated with 6-thioguanine and UVA (2011) (39)
- Cellular defence mechanisms against alkylating agents. (1985) (39)
- DNA breakage and cell cycle checkpoint abrogation induced by a therapeutic thiopurine and UVA radiation (2010) (39)
- Possible depletion of a DNA repair enzyme in human lymphoma cells by subversive repair. (1985) (38)
- DNA replication arrest and tolerance to DNA methylation damage. (1994) (35)
- Topical photodynamic therapy with methyl aminolevulinate to treat sebaceous hyperplasia in an organ transplant recipient. (2006) (35)
- The cytotoxicity of DNA carboxymethylation and methylation by the model carboxymethylating agent azaserine in human cells. (1999) (35)
- Incision at DNA G.T mispairs by extracts of mammalian cells occurs preferentially at cytosine methylation sites and is not targeted by a separate G.T binding reaction. (1993) (34)
- Epigenetic silencing of the DNA repair enzyme O6-methylguanine-DNA methyltransferase in Mex- human cells. (1992) (34)
- Selective binding to DNA base pair mismatches by proteins from human cells. (1989) (33)
- Oxidative stress induced by UVA photoactivation of the tryptophan UVB photoproduct 6-formylindolo[3,2-b]carbazole (FICZ) inhibits nucleotide excision repair in human cells (2017) (33)
- Oxidation-mediated DNA cross-linking contributes to the toxicity of 6-thioguanine in human cells. (2012) (33)
- Mismatch repair and p53 independently affect sensitivity to N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea. (2000) (31)
- Mismatch binding proteins and tolerance to alkylating agents in human cells. (1990) (31)
- Identification of potentially cytotoxic lesions induced by UVA photoactivation of DNA 4-thiothymidine in human cells (2011) (30)
- Repair of depurinated DNA in vitro by enzymes purified from human lymphoblasts. (1978) (29)
- An adaptive response to the cytotoxic effects of N-methyl-N-nitrosourea is apparently absent in normal human fibroblasts. (1982) (29)
- Replication of 2-hydroxyadenine-containing DNA and recognition by human MutSalpha. (2007) (28)
- Intermediates in excision repair by human cells: use of S1 nuclease and benzoylated naphthoylated cellulose to reveal single-strand breaks. (1977) (28)
- Death of an enzyme: suicide repair of DNA (1983) (27)
- Frameshift mismatch recognition by the human MutSα complex (1998) (27)
- Repeated Sequences in CASPASE-5 and FANCD2 but not NF1 Are Targets for Mutation in Microsatellite-Unstable Acute Leukemia/Myelodysplastic Syndrome (2005) (26)
- DNA repair inhibition by UVA photoactivated fluoroquinolones and vemurafenib (2014) (25)
- Combined mismatch and nucleotide excision repair defects in a human cell line: mismatch repair processes methylation but not UV- or ionizing radiation-induced DNA damage. (1999) (25)
- Properties of N-methyl-N-nitrosourea-resistant, Mex- derivatives of an SV40-immortalized human fibroblast cell line. (1989) (24)
- 6‐Thioguanine damages mitochondrial DNA and causes mitochondrial dysfunction in human cells (2011) (24)
- hMSH2-independent DNA Mismatch Recognition by Human Proteins (*) (1996) (24)
- Appropriate partners make good matches. (1995) (23)
- O6-methylguanine in DNA inhibits replication in vitro by human cell extracts. (1993) (23)
- Photo‐oxidation of 6‐Thioguanine by UVA: The Formation of Addition Products with Low Molecular Weight Thiol Compounds (2010) (22)
- Ambiguous coding is required for the lethal interaction between methylated DNA bases and DNA mismatch repair. (2002) (22)
- 4-Thio-5-bromo-2'-deoxyuridine: chemical synthesis and therapeutic potential of UVA-induced DNA damage. (2004) (20)
- Efficient repair of A/C mismatches in mouse cells deficient in long‐patch mismatch repair (2000) (20)
- Thiothymidine plus low-dose UVA kills hyperproliferative human skin cells independently of their human papilloma virus status (2007) (19)
- Immune effector cells produce lethal DNA damage in cells treated with a thiopurine. (2009) (19)
- UVA photoactivation of DNA containing halogenated thiopyrimidines induces cytotoxic DNA lesions (2015) (19)
- The contribution of O6-methylguanine and methylphosphotriesters to the cytotoxicity of alkylating agents in mammalian cells. (1988) (18)
- Inducible DNA repair enzymes involved in the adaptive response to alkylating agents. (1982) (17)
- 11 – Mechanisms of DNA Excision Repair in Human Cells (1978) (17)
- Variation in the loss of O6-methylguanine-DNA methyltransferase during immortalization of human fibroblasts. (1990) (17)
- Coregulation of the human O6-methylguanine-DNA methyltransferase with two unrelated genes that are closely linked. (1990) (17)
- Carmustine-induced toxicity, DNA crosslinking and O6-methylguanine-DNA methyltransferase activity in two human lung cancer cell lines. (1991) (17)
- Structural and dynamic effects of single 7-hydro-8-oxoguanine bases located in a frameshift target DNA sequence. (2005) (17)
- Inactive O6-methylguanine-DNA methyltransferase in human cells. (1992) (16)
- DNA mismatch repair in lymphoblastoid cells from hereditary non-polyposis colorectal cancer (HNPCC) patients is normal under conditions of rapid cell division and increased mutational load. (1997) (16)
- Excision of O6-methylguanine from DNA by human fibroblasts determined by a sensitive competition method. (1982) (15)
- Active site amino acid sequence of the bovine O6-methylguanine-DNA methyltransferase (1990) (14)
- The repair of methyl methanesulphonate-induced lesions in the DNA of a murine lymphoma cell. (1973) (14)
- Photosensitized UVA-Induced Cross-Linking between Human DNA Repair and Replication Proteins and DNA Revealed by Proteomic Analysis (2016) (12)
- MUTYH mediates the toxicity of combined DNA 6-thioguanine and UVA radiation (2014) (12)
- DNA Mismatch Repair (1998) (11)
- Localization of the human O6-methylguanine-DNA methyltransferase gene to chromosome 10q24.33-qter. (1991) (11)
- Expression of DNA mismatch repair proteins and MSH2 polymorphisms in nonmelanoma skin cancers of organ transplant recipients (2009) (11)
- Carcinogenic mechanisms related to immunosuppressive therapy. (2009) (11)
- Frameshift mismatch recognition by the human MutS alpha complex. (1998) (11)
- The adaptive response to alkylating agents: the removal of O6-methylguanine from DNA is not dependent on DNA polymerase-1. (1982) (10)
- The involvement of mismatch repair in transcription coupled nucleotide excision repair (2008) (10)
- Enzymatic removal of mutagenic and lethal lesions from alkylated DNA. (1983) (6)
- Alkylation damage and DNA excision repair in mammalian cells. (1977) (6)
- DNA repair. (1981) (5)
- 5-Iodo-4-thio-2′-deoxyuridine: Synthesis, Structure, and Cytotoxic Activity (2015) (5)
- O6‐Methylguanine in DNA Inhibits DNA Replication and Stimulates DNA Repair Synthesis in Vitro (1994) (5)
- XPC lymphoblastoid cells defective in the hMutSalpha DNA mismatch repair complex exhibit normal sensitivity to UVC radiation and normal transcription-coupled excision repair of DNA cyclobutane pyrimidine dimers. (2004) (5)
- Human Mismatch Repair: Defects and Predisposition to Cancer (2001) (4)
- Regulation of O6-methylguanine-DNA methyltransferase expression in the Burkitt's lymphoma cell line Raji. (1990) (4)
- DNA GLYCOSYLASES OF ESCHERICHIA COLI (1978) (4)
- DNA Repair by the Ada Protein of E. coli (1988) (3)
- Site-dependent inhibition by single O6-methylguanine bases of SV40 T-antigen interactions with the viral origin of replication. (1991) (3)
- Mammalian Cells Defective in DNA Mismatch Correction (1994) (2)
- Young transgenic hMTH1 mice are protected against dietary fat‐induced metabolic stress—implications for enhanced longevity (2022) (2)
- Non-genetic factors affecting the quantitative repair capability of cells (1976) (2)
- S1775 Development of a New Class of Thiopurine-Based Immunosuppressive Agents: Improved Ratio Between High Immunosuppressive Effects and Low Associated Toxicity (2010) (1)
- MECHANISMS OF REPAIR OF METHYLATED BASES IN THE DNA OF ESCHERICHIA COLI (1980) (1)
- Abstracts of Workshop (2013) (1)
- leukemia/myelodysplastic syndrome after organ transplantation Defective DNA mismatch repair in acute myeloid (2013) (0)
- Repair of depurinated DNA in vitr human lymphoblasts (2016) (0)
- Genes in Cells Resistant to Methylating Agents DNA Repair hMSH 6 and MGMT Epigenetic Regulation of the Updated (2000) (0)
- Alkylation ofD NA forms lethal and mutagenic lesions, most of which are repaired by conventional enzymes. A unique activity has been discovered which corrects an important mutagenic adduct in one step, by a self-destructive mechanism. (1983) (0)
- Deficiency of Human Peripheral Blood Lymphocytes Treated with Chemical Carcinogens1 (2006) (0)
- DNA Damage and Repair OxidativeStress – InducedProteinDamage Inhibits DNA Repair and Determines Mutation Risk and Therapeutic Ef fi cacy (2016) (0)
- Efficient long DNA gap-filling in a mammalian cell-free system: a potential new in vitro DNA replication assay. (2013) (0)
- Mechanisms of Alkylating Agent Induced Cytotoxicity in E.coli and Mammalian Cells (1989) (0)
- Response to Emanuele. (2014) (0)
- 4‐Thio‐5‐bromo‐2′‐deoxyuridine: Chemical Synthesis and Therapeutic Potential of UVA‐Induced DNA Damage. (2004) (0)
- Mismatch repair defects among italian cases of secondary acute leukemia and myelodysplastic syndrome (2001) (0)
- Thiothymidine plus low-dose UVA kills hyperproliferativehuman skin cells independently of their human papilloma virus status Journal Item (2018) (0)
- Repair of cytotoxic lesions introduced into DNA by methylating agents. (1989) (0)
- The Phase Contrast Microscope - Can It Be Used In Schools?. (1972) (0)
- The Molecular Basis of Alkylating Agent Resistance in Mammalian Cells (1989) (0)
- O III B.2 DNA mismatch repair defects in drug resistance (1997) (0)
- Different pathways for the excision repair of DNA in human cells (1978) (0)
- EPIGENETIC SILENCING OF A HUMAN DNA REPAIR GENE ' " changes in gene expression resulting from abrupt shifts in CpG methylation in human DNA (2006) (0)
- Normal expression of thymidine kinase and O6-methylguanine-DNA methyltransferase in cultured fibroblasts from individuals with hereditary galactokinase deficiency (1991) (0)
- THIOTHYMIDINE COMBINED WITH RALTITREXED AND UVA AS A POTENTIAL THERAPY FOR BLADDER CANCER (2006) (0)
- and other research outputs Guanine sulphinate is a major stable product of photochemical oxidation of DNA 6thioguanine 6thioguanine 6thioguanine by UVA irradiation (2016) (0)
- Coregulation of the Human 06-Methylguanine-DNA Methyltransferase with Two Unrelated Genes That Are Closely Linked 1 (2006) (0)
- Oxidative stress induced by UVA photoactivation of the tryptophan UVB photoproduct 6-formylindolo[3,2-b]carbazole (FICZ) inhibits nucleotide excision repair in human cells (2017) (0)
- Facts and hypotheses about DNA methylation DNA Methylation and Gene Regulation (1990). Edited by R. Holliday, M. Monk and J. E. Pugh. The Royal Society: London. 161pp. £35 (1990) (0)
- Normal expression of thymidine kinase and O6-methylguanine-DNA methyltransferase in cultured fibroblasts from individuals with hereditary galactokinase deficiency (2004) (0)
- Repair of O6-methylguanine in bacterial DNA: mechanismsof mutation avoidance after alkylation (1982) (0)
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What Schools Are Affiliated With Peter Karran?
Peter Karran is affiliated with the following schools:
