Peter Keightley | Academic Influence

Peter Keightley's AcademicInfluence.com Rankings

Peter Keightley

Biology

#1789

World Rank

#2905

Historical Rank

Evolutionary Biology

#188

World Rank

#209

Historical Rank

Genetics

#349

World Rank

#411

Historical Rank

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Biology

Why Is Peter Keightley Influential?

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According to Wikipedia, Peter D. Keightley FRS is Professor of Evolutionary Genetics at the Institute of Evolutionary Biology in School of Biological Sciences at the University of Edinburgh. Education Keightley was educated at the University of Edinburgh where he was awarded a PhD in 1989 for research on genetic variation supervised by William G. Hill. During his doctoral work he collaborated with Henrik Kacser on a highly cited paper on genetic dominance.

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Peter Keightley's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Evolution of genes and genomes on the Drosophila phylogeny (2007) (1992)
The distribution of fitness effects of new mutations (2007) (1233)
Estimating the rate of adaptive molecular evolution in the presence of slightly deleterious mutations and population size change. (2009) (397)
Multifactorial genetics: Understanding quantitative genetic variation (2002) (397)
High genomic deleterious mutation rates in hominids (1999) (375)
Spontaneous Mutation Accumulation Studies in Evolutionary Genetics (2009) (346)
Direct estimation of per nucleotide and genomic deleterious mutation rates in Drosophila (2007) (345)
Analysis of the genome sequences of three Drosophila melanogaster spontaneous mutation accumulation lines. (2009) (341)
Interference among deleterious mutations favours sex and recombination in finite populations (2006) (336)
Joint Inference of the Distribution of Fitness Effects of Deleterious Mutations and Population Demography Based on Nucleotide Polymorphism Frequencies (2007) (330)
Enhanced CpG Mutability and Tumorigenesis in MBD4-Deficient Mice (2002) (325)
Direct Estimation of the Mitochondrial DNA Mutation Rate in Drosophila melanogaster (2008) (269)
Ubiquitous selective constraints in the Drosophila genome revealed by a genome-wide interspecies comparison. (2006) (251)
The distribution of mutation effects on viability in Drosophila melanogaster. (1994) (243)
Evidence for Widespread Degradation of Gene Control Regions in Hominid Genomes (2005) (220)
Estimation of the Spontaneous Mutation Rate per Nucleotide Site in a Drosophila melanogaster Full-Sib Family (2013) (220)
Deleterious mutations and the evolution of sex. (2000) (216)
Quantifying the slightly deleterious mutation model of molecular evolution. (2002) (209)
Genomic mutation rates for lifetime reproductive output and lifespan in Caenorhabditis elegans. (1997) (205)
Estimation of the Spontaneous Mutation Rate in Heliconius melpomene (2014) (182)
Rates and Fitness Consequences of New Mutations in Humans (2012) (181)
Current hypotheses for the evolution of sex and recombination. (2012) (160)
The Effect of Variation in the Effective Population Size on the Rate of Adaptive Molecular Evolution in Eukaryotes (2012) (150)
High frequency of cryptic deleterious mutations in Caenorhabditis elegans. (1999) (148)
A pleiotropic nonadditive model of variation in quantitative traits. (1994) (147)
Terumi Mukai and the riddle of deleterious mutation rates. (1999) (145)
Nature of deleterious mutation load in Drosophila. (1996) (144)
TOWARD A REALISTIC MODEL OF MUTATIONS AFFECTING FITNESS (2003) (138)
Variation maintained in quantitative traits with mutation–selection balance: pleiotropic side-effects on fitness traits (1990) (135)
New estimates of the rates and effects of mildly deleterious mutation in Drosophila melanogaster. (1999) (131)
Evidence for Pervasive Adaptive Protein Evolution in Wild Mice (2010) (125)
Intron Size and Exon Evolution in Drosophila (2005) (118)
Patterns of evolutionary constraints in intronic and intergenic DNA of Drosophila. (2004) (117)
Functional constraints and frequency of deleterious mutations in noncoding DNA of rodents (2003) (115)
Global population divergence and admixture of the brown rat (Rattus norvegicus) (2016) (114)
Estimate of the Spontaneous Mutation Rate in Chlamydomonas reinhardtii (2012) (114)
A genetic map of quantitative trait loci for body weight in the mouse. (1996) (113)
A Method for Inferring the Rate of Occurrence and Fitness Effects of Advantageous Mutations (2011) (108)
Models of quantitative variation of flux in metabolic pathways. (1989) (104)
A Comparison of Models to Infer the Distribution of Fitness Effects of New Mutations (2013) (101)
Extensive de novo mutation rate variation between individuals and across the genome of Chlamydomonas reinhardtii (2015) (99)
Distributions of selectively constrained sites and deleterious mutation rates in the hominid and murid genomes. (2010) (96)
The scale of mutational variation in the murid genome. (2005) (94)
Contributions of Protein-Coding and Regulatory Change to Adaptive Molecular Evolution in Murid Rodents (2013) (93)
Proceedings of the 5th World Congress on Genetics Applied to Livestock Production (1994) (93)
Dominance, pleiotropy and metabolic structure. (1987) (88)
EMS-induced polygenic mutation rates for nine quantitative characters in Drosophila melanogaster. (1998) (88)
What can we learn about the distribution of fitness effects of new mutations from DNA sequence data? (2010) (88)
Quantitative genetic variability maintained by mutation-stabilizing selection balance in finite populations. (1988) (86)
Mapping of obesity QTLs in a cross between mouse lines divergently selected on fat content (2000) (85)
Detecting positive selection in the genome (2017) (74)
Genomic Selective Constraints in Murid Noncoding DNA (2006) (72)
Spontaneous mutational variation for body size in Caenorhabditis elegans. (2002) (70)
Estimating the Rate of Adaptive Molecular Evolution When the Evolutionary Divergence Between Species is Small (2012) (67)
Bottleneck effect on genetic variance. A theoretical investigation of the role of dominance. (1998) (67)
Inferring the Probability of the Derived vs. the Ancestral Allelic State at a Polymorphic Site (2018) (66)
Directional selection and variation in finite populations. (1987) (65)
Dominance and overdominance of mildly deleterious induced mutations for fitness traits in Caenorhabditis elegans. (2003) (65)
MCALIGN: stochastic alignment of noncoding DNA sequences based on an evolutionary model of sequence evolution. (2004) (63)
PAPPA2, an Enzyme That Cleaves an Insulin-Like Growth-Factor-Binding Protein, Is a Candidate Gene for a Quantitative Trait Locus Affecting Body Size in Mice (2006) (62)
A metabolic basis for dominance and recessivity. (1996) (62)
Inference of genome-wide mutation rates and distributions of mutation effects for fitness traits: a simulation study. (1998) (61)
Evolutionary constraints in conserved nongenic sequences of mammals. (2005) (61)
Properties of ethylmethane sulfonate-induced mutations affecting life-history traits in Caenorhabditis elegans and inferences about bivariate distributions of mutation effects. (2000) (60)
The Nature of Genetic Variation for Complex Traits Revealed by GWAS and Regional Heritability Mapping Analyses (2015) (59)
Faster-X Adaptive Protein Evolution in House Mice (2013) (55)
Regulatory Variation at Glypican-3 Underlies a Major Growth QTL in Mice (2005) (54)
Mitochondrial Mutation Rate, Spectrum and Heteroplasmy in Caenorhabditis elegans Spontaneous Mutation Accumulation Lines of Differing Population Size (2017) (53)
Quantitative genetic variation in body size of mice from new mutations. (1992) (53)
Quantitative trait loci for growth traits in C57BL/6J × DBA/2J mice (1999) (52)
A test for epistasis among induced mutations in Caenorhabditis elegans. (2000) (50)
Detection of quantitative trait loci from frequency changes of marker alleles under selection. (1993) (49)
Inferring the Frequency Spectrum of Derived Variants to Quantify Adaptive Molecular Evolution in Protein-Coding Genes of Drosophila melanogaster (2016) (47)
Accounting for bias in estimates of the rate of polygenic mutation (1993) (46)
Test of candidate gene–quantitative trait locus association applied to fatness in mice (1998) (44)
Analysis and implications of mutational variation (2009) (44)
Multigeneration maximum-likelihood analysis applied to mutation-accumulation experiments in Caenorhabditis elegans. (2000) (43)
A Resolution of the Mutation Load Paradox in Humans (2012) (43)
Genetic basis of response to 50 generations of selection on body weight in inbred mice. (1998) (42)
RATES OF MOLECULAR EVOLUTION IN NUCLEAR GENES OF EAST MEDITERRANEAN SCORPIONS (2004) (42)
Metabolic models of selection response. (1996) (42)
Mapping quantitative trait loci for body weight on the X chromosome in mice. I. Analysis of a reciprocal F2 population. (1997) (42)
The Role of Advantageous Mutations in Enhancing the Evolution of a Recombination Modifier (2010) (41)
Rates of change of genetic parameters of body weight in selected mouse lines. (1995) (39)
DNA Sequence Error Rates in Genbank Records Estimated using the Mouse Genome as a Reference (2004) (39)
Direct estimation of per nucleotide and genomic deleterious mutation rates in Drosophila (2008) (38)
Microarray gene expression analysis of the Fob3b obesity QTL identifies positional candidate gene Sqle and perturbed cholesterol and glycolysis pathways. (2005) (38)
Genetic complexity of an obesity QTL (Fob3) revealedby detailed genetic mapping (2004) (37)
Effects of linkage on response to directional selection from new mutations. (1983) (36)
Fitness decline in spontaneous mutation accumulation lines of Caenorhabditis elegans with varying effective population sizes (2015) (36)
Strategies for increasing fixation probabilities of recessive mutations (1991) (36)
Inferring the distribution of fitness effects of spontaneous mutations in Chlamydomonas reinhardtii (2019) (36)
Inference of Site Frequency Spectra From High-Throughput Sequence Data: Quantification of Selection on Nonsynonymous and Synonymous Sites in Humans (2011) (35)
Recent Evolution in Rattus norvegicus Is Shaped by Declining Effective Population Size (2015) (35)
SPONTANEOUS MUTATION ACCUMULATION IN MULTIPLE STRAINS OF THE GREEN ALGA, CHLAMYDOMONAS REINHARDTII (2014) (34)
Positive and negative selection on noncoding DNA close to protein-coding genes in wild house mice. (2011) (33)
Fine mapping of a murine growth locus to a 1.4-cM region and resolution of linked QTL (2004) (33)
Positive and negative selection in murine ultraconserved noncoding elements. (2011) (32)
MCALIGN2: Faster, accurate global pairwise alignment of non-coding DNA sequences based on explicit models of indel evolution (2006) (32)
Understanding the Factors That Shape Patterns of Nucleotide Diversity in the House Mouse Genome (2018) (30)
Characterization of a QTL affecting skeletal size in mice (2003) (30)
Quantitative genetic variability maintained by mutation-stabilizing selection balance: sampling variation and response to subsequent directional selection. (1989) (28)
Direct estimate of the spontaneous mutation rate uncovers the effects of drift and recombination in the Chlamydomonas reinhardtii plastid genome (2015) (28)
The Recombination Landscape in Wild House Mice Inferred Using Population Genomic Data (2017) (27)
Mapping quantitative trait loci affecting sternopleural bristle number in Drosophila melanogaster using changes of marker allele frequencies in divergently selected lines. (1998) (27)
Recommendations for improving statistical inference in population genomics (2021) (26)
Population genetics: Surviving under mutation pressure (1998) (25)
Unexpected conserved non-coding DNA blocks in mammals. (2004) (24)
High-resolution quantitative trait locus mapping for body weight in mice by recombinant progeny testing. (2001) (24)
Mapping quantitative trait loci for body weight on the X chromosome in mice. II. Analysis of congenic backcrosses. (1997) (24)
Testing the correspondence between map positions of quantitative trait loci. (1999) (23)
Average dominance for polygenes: drawbacks of regression estimates. (1997) (23)
Patterns of selective constraints in noncoding DNA of rice (2007) (23)
Comparative genomics of Chlamydomonas (2020) (23)
Inference of Mutation Parameters and Selective Constraint in Mammalian Coding Sequences by Approximate Bayesian Computation (2011) (22)
Nuclear Gene Variation in Wild Brown Rats (2012) (22)
Effect of the assignment of ancestral CpG state on the estimation of nucleotide substitution rates in mammals (2008) (21)
Effect of Divergence Time and Recombination Rate on Molecular Evolution of Drosophila INE-1 Transposable Elements and Other Candidates for Neutrally Evolving Sites (2007) (21)
Genetic instability of C. elegans comes naturally. (2005) (21)
Mutational Variation and Long‐Term Selection Response (2010) (20)
Fitness effects of new mutations in Chlamydomonas reinhardtii across two stress gradients (2015) (19)
Fitness decline under osmotic stress in Caenorhabditis elegans populations subjected to spontaneous mutation accumulation at varying population sizes (2018) (18)
Accumulation of mutations affecting body weight in inbred mouse lines. (1995) (18)
Fitness change in relation to mutation number in spontaneous mutation accumulation lines of Chlamydomonas reinhardtii (2017) (17)
Chewing the fat (1995) (17)
Estimating numbers of EMS-induced mutations affecting life history traits in Caenorhabditis elegans in crosses between inbred sublines. (2003) (16)
THE MAINTENANCE OF OBLIGATE SEX IN FINITE, STRUCTURED POPULATIONS SUBJECT TO RECURRENT BENEFICIAL AND DELETERIOUS MUTATION (2012) (15)
Inferences on genome-wide deleterious mutation rates in inbred populations of Drosophila and mice (2004) (15)
How many lethal alleles? (2003) (14)
Response to Kondrashov. (2001) (14)
Quantitative trait loci for growth traits in C57BL/6J x DBA/2J mice. (1999) (14)
Patterns of DNA-Sequence Divergence Between Drosophila miranda and D. pseudoobscura (2009) (13)
The use of retrotransposons as markers for mapping genes responsible for fitness differences between related Drosophila melanogaster strains. (1993) (12)
Assessing Recent Selection and Functionality at Long Noncoding RNA Loci in the Mouse Genome (2015) (12)
Patterns of population structure and complex haplotype sharing among field isolates of the green alga Chlamydomonas reinhardtii (2019) (12)
Characterization of a major X-linked quantitative trait locus influencing body weight of mice. (2001) (11)
Genetic variance and fixation probabilities at quantitative trait loci in mutation-selection balance (1991) (11)
Quantitative Genetics: Loci with large effects (1995) (10)
Inbred lab mice are not isogenic: genetic variation within inbred strains used to infer the mutation rate per nucleotide site (2020) (10)
De Novo Mutation Rate Variation and Its Determinants in Chlamydomonas (2021) (10)
Understanding the Degradation of Hominid Gene Control (2006) (9)
Genetic Architecture: Dissecting the Genetic Basis of Phenotypic Variation (2002) (9)
Comparing Analysis Methods for Mutation-Accumulation Data (2004) (9)
Cis-regulatory evolution spotlights species differences in the adaptive potential of gene expression plasticity (2020) (9)
Effects of multiple retrovirus insertions on quantitative traits of mice. (1993) (8)
Estimating new mutational variation in growth rate of mice. (1990) (6)
Selective interference among deleterious mutations favours sex and recombination in finite populations regardless of the nature of epistasis (2006) (5)
Mutational variation and long-term selection response. Plant Breeding Reviews (2004) (4)
The distribution of fitness effects of spontaneous mutations in Chlamydomonas reinhardtii inferred using frequency changes under experimental evolution (2021) (4)
Analysis of mutation accumulation experiments: response to Deng, Li and Li (1999) (4)
Mapping of putative QTL influencing body weight on the X chromosome in mice. (1994) (4)
Quantitative genetics: Resolving wing shape genes (2000) (3)
Rates and spectra of de novo structural mutations in Chlamydomonas reinhardtii (2022) (3)
Genomic Selective Constraints in Murids (2005) (3)
The response of a carbon-fibre phenolic resin composite to one-dimensional shock loading (2009) (3)
Estimating the Rate of Adaptive Molecular Evolution When the Evolutionary Divergence Between Species is Small (2012) (3)
Variation from spontaneous mutation for body size in the mouse. (1994) (3)
Behavioural Genetics: Finding Genes that Cause Complex Trait Variation (2005) (2)
Selective sweeps influence diversity over large regions of the mouse genome (2021) (2)
Mapping quantitative trait loci for body weight on the X chromosome in mice . I . Analysis of a reciprocal F # population (1997) (2)
Introduction: population genetics, quantitative genetics and animal improvement: papers in honour of William (Bill) Hill (2005) (2)
Variation in mutation, recombination, and transposition rates in Drosophila melanogaster and Drosophila simulans (2022) (2)
Drosophila of of Evolutionary Constraints in Intronic and Intergenic DNA (2007) (1)
Inbred lab mice are not isogenic: genetic variation within inbred strains used to infer the mutation rate per nucleotide site (2020) (1)
Direct inference of the distribution of fitness effects of spontaneous mutations in Chlamydomonas reinhardtii (2019) (1)
Changes of genetic variance and frequencies of marker alleles in mouse lines selected on 6-week weight. (1994) (1)
Drosophila melanogaster full-sib family (2013) (1)
Mitochondrial Mutation Rate, Spectrum and Heteroplasmy in Caenorhabditis elegans Spontaneous Mutation Accumulation Lines of Differing Population Size. (2017) (1)
Faculty Opinions recommendation of Precise estimates of mutation rate and spectrum in yeast. (2014) (0)
Detecting positive selection in the genome (2017) (0)
An Equation of State study of a Boron Nitride rubber composite using a Single Stage Gas Gun (2007) (0)
of papers presented at the fourteenth Genetics Society’s Mammalian Genetics and Development Workshop held at the Institute of Child Health, University College London on 3 and 4 2003 (2004) (0)
Explorer Understanding the Degradation of Hominid Gene Control (2016) (0)
PASCAL programming - problems and application : D T Barnard and RG Crawford Reston Publishing Co., Reston, VA, USA (September 1982) £17.05, pp 274 (1983) (0)
Running title: Fitness effects of new mutations under stress (2015) (0)
Explorer MCALIGN 2 : faster , accurate global pairwise alignment of non-coding DNA sequences based on explicit models of indel evolution (2017) (0)
Life's formula (1989) (0)
KEIGHTLEY QUANTITATIVE GENETICS Loci with large effects Recent studies with the fruitfly Drosophila suggest that (2004) (0)
Title: Recent evolution in Rattus norvegicus is shaped by (2015) (0)
William G. Hill (1940–2021) (2022) (0)
Title : Global population divergence and admixture of the brown rat ( Rattus norvegicus ) 2 3 (2016) (0)
Studies of quantitative genetic variation (1988) (0)
PAPPA2 , an enzyme that cleaves an insulin-like growth factor binding protein, is a candidate gene for a QTL affecting body size in mice (2006) (0)
Supplementary material from "Global population divergence and admixture of the brown rat ( Rattus norvegicus )" (2016) (0)
Explorer Genetic complexity of an obesity QTL ( Fob 3 ) revealed by detailed genetic mapping (2017) (0)
DFE-alpha data tables (2017) (0)
The development of a smaller Asay foil diagnostic (2018) (0)
Low rates of proviral integration in SWR/J-RF/J hybrid mice. (1995) (0)
Explorer Genomic Selective Constraints in Murid Noncoding DNA (2017) (0)

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What Schools Are Affiliated With Peter Keightley?

Peter Keightley is affiliated with the following schools:

University of Edinburgh

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