Peter Walter | Academic Influence

Peter Walter's AcademicInfluence.com Rankings

Peter Walter

Biology

#250

World Rank

#451

Historical Rank

#145

USA Rank

Biochemistry

#87

World Rank

#115

Historical Rank

#51

USA Rank

biology Degrees

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Biology

Why Is Peter Walter Influential?

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According to Wikipedia, Peter Walter is a German-American molecular biologist and biochemist. He is currently the Director of the Bay Area Institute of Science at Altos Labs and an emeritus professor at the Department of Biochemistry and Biophysics of the University of California, San Francisco . He was a Howard Hughes Medical Institute Investigator until 2022.

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Peter Walter's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Signal integration in the endoplasmic reticulum unfolded protein response (2007) (5765)
The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation (2011) (4583)
Functional and Genomic Analyses Reveal an Essential Coordination between the Unfolded Protein Response and ER-Associated Degradation (2000) (1971)
IRE1 Signaling Affects Cell Fate During the Unfolded Protein Response (2007) (1265)
Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase (1993) (1188)
An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen (2009) (1119)
A Novel Mechanism for Regulating Activity of a Transcription Factor That Controls the Unfolded Protein Response (1996) (1018)
Autophagy Counterbalances Endoplasmic Reticulum Expansion during the Unfolded Protein Response (2006) (971)
Molecular Biology of the Cell (Fifth Edition) (2008) (934)
Regulated Ire1-dependent decay of messenger RNAs in mammalian cells (2009) (894)
The Transmembrane Kinase Ire1p Is a Site-Specific Endonuclease That Initiates mRNA Splicing in the Unfolded Protein Response (1997) (863)
Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals. (2001) (810)
Signal sequence recognition and protein targeting to the endoplasmic reticulum membrane. (1994) (793)
Translocation of proteins across the endoplasmic reticulum III. Signal recognition protein (SRP) causes signal sequence-dependent and site- specific arrest of chain elongation that is released by microsomal membranes (1981) (689)
Signal recognition particle contains a 7S RNA essential for protein translocation across the endoplasmic reticulum (1982) (670)
Protein translocation across the endoplasmic reticulum (1984) (668)
Functional genomic screen reveals genes involved in lipid-droplet formation and utilization (2008) (655)
The signal recognition particle. (2001) (646)
Endoplasmic reticulum stress in disease pathogenesis. (2008) (646)
Comprehensive Characterization of Genes Required for Protein Folding in the Endoplasmic Reticulum (2009) (633)
Unfolded Proteins Are Ire1-Activating Ligands That Directly Induce the Unfolded Protein Response (2011) (598)
Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus. (1996) (598)
The unfolded protein response signals through high-order assembly of Ire1 (2009) (597)
Endoplasmic reticulum stress sensing in the unfolded protein response. (2013) (581)
Preparation of microsomal membranes for cotranslational protein translocation. (1983) (567)
Translocation of proteins across the endoplasmic reticulum. I. Signal recognition protein (SRP) binds to in-vitro-assembled polysomes synthesizing secretory protein (1981) (557)
Intracellular signaling by the unfolded protein response. (2006) (534)
On the mechanism of sensing unfolded protein in the endoplasmic reticulum. (2005) (532)
Pharmacological brake-release of mRNA translation enhances cognitive memory (2013) (479)
Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response (2009) (464)
Signal sequences specify the targeting route to the endoplasmic reticulum membrane (1996) (457)
Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis (2014) (456)
Model for signal sequence recognition from amino-acid sequence of 54K subunit of signal recognition particle (1989) (447)
Protein translocation across the endoplasmic reticulum. II. Isolation and characterization of the signal recognition particle receptor (1982) (444)
The integrated stress response: From mechanism to disease (2020) (441)
Purification of a membrane-associated protein complex required for protein translocation across the endoplasmic reticulum. (1980) (435)
tRNA Ligase Is Required for Regulated mRNA Splicing in the Unfolded Protein Response (1996) (435)
Ribosome pausing and stacking during translation of a eukaryotic mRNA. (1988) (420)
Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiae. (1999) (417)
Mechanism of protein translocation across the endoplasmic reticulum membrane. (1986) (412)
The unfolded protein response coordinates the production of endoplasmic reticulum protein and endoplasmic reticulum membrane. (1997) (398)
The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly (2015) (394)
Gene Recruitment of the Activated INO1 Locus to the Nuclear Membrane (2004) (382)
BiP Binding to the ER-Stress Sensor Ire1 Tunes the Homeostatic Behavior of the Unfolded Protein Response (2010) (365)
The Unfolded Protein Response Regulates Multiple Aspects of Secretory and Membrane Protein Biogenesis and Endoplasmic Reticulum Quality Control (2000) (347)
ER-Phagy: Selective Autophagy of the Endoplasmic Reticulum (2007) (341)
Translocation of proteins across the endoplasmic reticulum. II. Signal recognition protein (SRP) mediates the selective binding to microsomal membranes of in-vitro-assembled polysomes synthesizing secretory protein (1981) (336)
Eisosomes mark static sites of endocytosis (2006) (329)
Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering (2010) (327)
Protein translocation across the endoplasmic reticulum. I. Detection in the microsomal membrane of a receptor for the signal recognition particle (1982) (327)
Messenger RNA targeting to endoplasmic reticulum stress signalling sites. (2009) (321)
The conserved GTPase Gem1 regulates endoplasmic reticulum–mitochondria connections (2011) (321)
Block of HAC1 mRNA Translation by Long-Range Base Pairing Is Released by Cytoplasmic Splicing upon Induction of the Unfolded Protein Response (2001) (308)
Photocrosslinking of the signal sequence of nascent preprolactin to the 54-kilodalton polypeptide of the signal recognition particle. (1986) (302)
Substrate twinning activates the signal recognition particle and its receptor (2004) (299)
Crystal Structure of the Signal Sequence Binding Subunit of the Signal Recognition Particle (1998) (298)
Divergent Effects of PERK and IRE1 Signaling on Cell Viability (2009) (297)
BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha. (2009) (290)
The signal recognition particle in S. cerevisiae (1991) (287)
A Role for Presenilin-1 in Nuclear Accumulation of Ire1 Fragments and Induction of the Mammalian Unfolded Protein Response (1999) (284)
The unfolded protein response: an intracellular signalling pathway with many surprising features. (1998) (284)
ER-associated mitochondrial division links the distribution of mitochondria and mitochondrial DNA in yeast (2013) (284)
An E. coli ribonucleoprotein containing 4.5S RNA resembles mammalian signal recognition particle. (1990) (270)
Intracellular signaling from the endoplasmic reticulum to the nucleus. (1998) (269)
In vitro protein translocation across the yeast endoplasmic reticulum: ATP-dependent post-translational translocation of the prepro-α-factor (1986) (268)
Intracellular protein topogenesis. (1980) (266)
Translocation of lipid-linked oligosaccharides across the ER membrane requires Rft1 protein (2002) (265)
Translation from the 5′ untranslated region shapes the integrated stress response (2016) (259)
Bypassing a Kinase Activity with an ATP-Competitive Drug (2003) (256)
An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike (2020) (249)
Structure of the conserved GTPase domain of the signal recognition particle (1997) (235)
ER-phagy mediates selective degradation of endoplasmic reticulum independently of the core autophagy machinery (2014) (233)
The methionine‐rich domain of the 54 kd protein subunit of the signal recognition particle contains an RNA binding site and can be crosslinked to a signal sequence. (1990) (232)
Targeting proteins to membranes: structure of the signal recognition particle. (2005) (226)
Reciprocal stimulation of GTP hydrolysis by two directly interacting GTPases (1995) (225)
Mechanism of non‐spliceosomal mRNA splicing in the unfolded protein response pathway (1999) (225)
The archaeal exosome core is a hexameric ring structure with three catalytic subunits (2005) (224)
Interaction of E. coli Ffh/4.5S ribonucleoprotein and FtsY mimics that of mammalian signal recognition particle and its receptor (1994) (224)
Each of the activities of signal recognition particle (SRP) is contained within a distinct domain: Analysis of biochemical mutants of SRP (1988) (222)
Molecular Cloning A Laboratory Manual Fourth Edition (2015) (218)
Structural basis of FFAT motif-mediated ER targeting. (2005) (213)
Disassembly and reconstitution of signal recognition particle (1983) (213)
Cell Junctions, Cell Adhesion, and the Extracellular Matrix (2002) (212)
Targeting of the hepatitis B virus precore protein to the endoplasmic reticulum membrane: after signal peptide cleavage translocation can be aborted and the product released into the cytoplasm (1988) (205)
Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response (2015) (202)
ERMES-mediated ER-mitochondria contacts: molecular hubs for the regulation of mitochondrial biology (2010) (196)
ER–mitochondrial junctions can be bypassed by dominant mutations in the endosomal protein Vps13 (2015) (196)
Structural basis of the unfolded protein response. (2012) (192)
Heavy-chain binding protein recognizes aberrant polypeptides translocated in vitro (1988) (192)
Translational attenuation mediated by an mRNA intron (1997) (189)
GTP binding and hydrolysis by the signal recognition particle during initiation of protein translocation (1993) (181)
Translocation of proteins across the endoplasmic reticulum. (1982) (180)
Prm1p, a Pheromone-Regulated Multispanning Membrane Protein, Facilitates Plasma Membrane Fusion during Yeast Mating (2000) (176)
The signal recognition particle receptor is a complex that contains two distinct polypeptide chains (1986) (176)
Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation (2016) (170)
Inaugural Article: On the mechanism of sensing unfolded protein in the endoplasmic reticulum (2005) (168)
The Unfolded Protein Response: Detecting and Responding to Fluctuations in the Protein-Folding Capacity of the Endoplasmic Reticulum. (2019) (164)
Translocation of proteins across membranes: the signal hypothesis and beyond. (1979) (164)
Gcn4p and Novel Upstream Activating Sequences Regulate Targets of the Unfolded Protein Response (2004) (161)
Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α (2014) (155)
Role of SRP RNA in the GTPase cycles of Ffh and FtsY. (2001) (155)
Human SRP RNA and E. coli 4.5S RNA contain a highly homologous structural domain (1988) (154)
The conserved AAA-ATPase Msp1 confers organelle specificity to tail-anchored proteins (2014) (154)
Targeting IRE1 with small molecules counteracts progression of atherosclerosis (2017) (152)
Protein translocation across the endoplasmic reticulum membrane: identification by photocross-linking of a 39-kD integral membrane glycoprotein as part of a putative translocation tunnel (1989) (151)
The unfolded-protein-response pathway in yeast. (1994) (151)
Removal of the Alu structural domain from signal recognition particle leaves its protein translocation activity intact (1986) (150)
An exosome‐like complex in Sulfolobus solfataricus (2003) (149)
The crystal structure of the dimerization initiation site of genomic HIV-1 RNA reveals an extended duplex with two adenine bulges. (1999) (149)
Elongation arrest is not a prerequisite for secretory protein translocation across the microsomal membrane (1985) (147)
An unfolded protein-induced conformational switch activates mammalian IRE1 (2017) (146)
Homeostatic adaptation to endoplasmic reticulum stress depends on Ire1 kinase activity (2011) (145)
Inhibition of the integrated stress response reverses cognitive deficits after traumatic brain injury (2017) (139)
Co‐translational protein targeting by the signal recognition particle (2005) (139)
Molecular sorting in the secretory pathway. (1989) (138)
Role of 4.5S RNA in assembly of the bacterial signal recognition particle with its receptor. (2000) (136)
Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule (2017) (130)
Signal recognition particle: a ribonucleoprotein required for cotranslational translocation of proteins, isolation and properties. (1983) (127)
Small molecule ISRIB suppresses the integrated stress response within a defined window of activation (2019) (127)
Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch (2016) (125)
Topology of signal recognition particle receptor in endoplasmic reticulum membrane (1985) (125)
A genome-wide screen for genes affecting eisosomes reveals Nce102 function in sphingolipid signaling (2009) (122)
The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis (2012) (121)
Pkh-kinases control eisosome assembly and organization (2007) (121)
Functional substitution of the signal recognition particle 54-kDa subunit by its Escherichia coli homolog. (1993) (118)
The Extracellular Matrix of Animals (2002) (115)
Subunits of the Saccharomyces cerevisiae signal recognition particle required for its functional expression. (1994) (115)
The beta subunit of the signal recognition particle receptor is a transmembrane GTPase that anchors the alpha subunit, a peripheral membrane GTPase, to the endoplasmic reticulum membrane (1995) (114)
Two endoplasmic reticulum (ER) membrane proteins that facilitate ER-to-Golgi transport of glycosylphosphatidylinositol-anchored proteins. (1999) (113)
A CHOP-regulated microRNA controls rhodopsin expression (2011) (112)
Mechanism of Association and Reciprocal Activation of Two GTPases (2004) (110)
Basis for regulated RNA cleavage by functional analysis of RNase L and Ire1p. (2001) (109)
Development of a stress response therapy targeting aggressive prostate cancer (2018) (109)
Signal sequence recognition and protein targeting. (1999) (107)
IRE 1 Signaling Affects Cell Fate During the Unfolded Protein Response (2008) (106)
Tryptic dissection and reconstitution of translocation activity for nascent presecretory proteins across microsomal membranes. (1979) (106)
Regulation of Organelle Biogenesis (1996) (105)
A nascent membrane protein is located adjacent to ER membrane proteins throughout its integration and translation (1991) (105)
A plasma-membrane E-MAP reveals links of the eisosome with sphingolipid metabolism and endosomal trafficking (2010) (105)
Signal recognition particle receptor is important for cell growth and protein secretion in Saccharomyces cerevisiae. (1992) (104)
The affinity of signal recognition particle for presecretory proteins is dependent on nascent chain length. (1988) (104)
SRP samples nascent chains for the presenceof signal sequences by interacting with ribosomes at a discrete step during translation elongation (1995) (104)
Saccharomyces cerevisiae and Schizosaccharomyces pombe contain a homologue to the 54-kD subunit of the signal recognition particle that in S. cerevisiae is essential for growth (1989) (104)
Protein translocation across the endoplasmic reticulum. (1994) (100)
The unfolded protein response element IRE1α senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling. (2013) (100)
A bacterial secretory protein requires signal recognition particle for translocation across mammalian endoplasmic reticulum. (1982) (98)
Multifaceted physiological response allows yeast to adapt to the loss of the signal recognition particle-dependent protein-targeting pathway. (2001) (97)
Mutants in three novel complementation groups inhibit membrane protein insertion into and soluble protein translocation across the endoplasmic reticulum membrane of Saccharomyces cerevisiae (1992) (97)
Binding sites of the 9- and 14-kilodalton heterodimeric protein subunit of the signal recognition particle (SRP) are contained exclusively in the Alu domain of SRP RNA and contain a sequence motif that is conserved in evolution. (1991) (96)
Signal recognition protein is required for the integration of acetylcholine receptor delta subunit, a transmembrane glycoprotein, into the endoplasmic reticulum membrane (1982) (96)
The Lipid Bilayer (2002) (93)
Validation of the Hsp70–Bag3 Protein–Protein Interaction as a Potential Therapeutic Target in Cancer (2015) (93)
RNA polyadenylation in Archaea: not observed in Haloferax while the exosome polynucleotidylates RNA in Sulfolobus (2005) (91)
The plasma membrane proteins Prm1 and Fig1 ascertain fidelity of membrane fusion during yeast mating. (2006) (91)
Functional changes in the structure of the SRP GTPase on binding GDP and Mg2+GDP (1999) (90)
Antimyeloma Effects of the Heat Shock Protein 70 Molecular Chaperone Inhibitor MAL3-101 (2011) (90)
The Shape and Structure of Proteins (2002) (90)
BAX inhibitor‐1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response (2011) (89)
Binding sites of the 19-kDa and 68/72-kDa signal recognition particle (SRP) proteins on SRP RNA as determined in protein-RNA "footprinting". (1988) (88)
Ceapins inhibit ATF6α signaling by selectively preventing transport of ATF6α to the Golgi apparatus during ER stress (2016) (87)
Signal Sequences Activate the Catalytic Switch of SRP RNA (2009) (85)
The nascent polypeptide-associated complex modulates interactions between the signal recognition particle and the ribosome (1996) (85)
Energy Conversion: Mitochondria and Chloroplasts (2002) (84)
Unraveling the interface of signal recognition particle and its receptor by using chemical cross-linking and tandem mass spectrometry. (2004) (83)
IRE1-Independent Gain Control of the Unfolded Protein Response (2004) (83)
ER membrane protein complex required for nuclear fusion (1996) (83)
Conformational changes in the GTPase modules of the signal reception particle and its receptor drive initiation of protein translocation (2007) (83)
Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndrome (2019) (83)
Automated identification of pathways from quantitative genetic interaction data (2010) (78)
The unfolded protein response signals through high-order assembly of Ire 1 (2008) (77)
Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits (2015) (74)
Genome-scale approaches for discovering novel nonconventional splicing substrates of the Ire1 nuclease (2004) (73)
eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response (2019) (70)
GTPase domain of the 54-kD subunit of the mammalian signal recognition particle is required for protein translocation but not for signal sequence binding (1993) (69)
Signal recognition particle mediates a transient elongation arrest of preprolactin in reticulocyte lysate (1989) (69)
The Cell-Division Cycle (1994) (69)
Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells. (2016) (69)
Helper T Cells and Lymphocyte Activation (2002) (68)
SEC65 gene product is a subunit of the yeast signal recognition particle required for its integrity (1992) (68)
A Functional GTPase Domain, but not its Transmembrane Domain, is Required for Function of the SRP Receptor β-subunit (1998) (67)
Subcellular distribution of signal recognition particle and 7SL-RNA determined with polypeptide-specific antibodies and complementary DNA probe (1983) (67)
Integrity of the yeast mitochondrial genome, but not its distribution and inheritance, relies on mitochondrial fission and fusion (2015) (67)
Assembly of the Alu domain of the signal recognition particle (SRP): dimerization of the two protein components is required for efficient binding to SRP RNA (1990) (67)
Heat Shock Transcription Factor σ32 Co-opts the Signal Recognition Particle to Regulate Protein Homeostasis in E. coli (2013) (65)
Disruption of IRE1α through its kinase domain attenuates multiple myeloma (2018) (65)
Cell-Cell Adhesion (2002) (64)
Pil1 controls eisosome biogenesis. (2008) (64)
Structural and functional basis for RNA cleavage by Ire1 (2011) (62)
Characterization of native and reconstituted exosome complexes from the hyperthermophilic archaeon Sulfolobus solfataricus (2006) (62)
The unfolded protein response during prostate cancer development (2009) (62)
Multiple selection filters ensure accurate tail-anchored membrane protein targeting (2016) (59)
Evidence for a two-step mechanism involved in assembly of functional signal recognition particle receptor (1989) (59)
Induced nucleotide specificity in a GTPase (2003) (59)
The Cell Cycle and Programmed Cell Death (2002) (58)
Misfolded proteins bind and activate death receptor 5 to trigger apoptosis during unresolved endoplasmic reticulum stress (2020) (58)
Isolation and characterization of a cDNA clone encoding the 19 kDa protein of signal recognition particle (SRP): expression and binding to 7SL RNA. (1988) (57)
Structure of sterol aliphatic chains affects yeast cell shape and cell fusion during mating (2010) (57)
Small ribonucleoproteins in Schizosaccharomyces pombe and Yarrowia lipolytica homologous to signal recognition particle. (1988) (56)
Identification of yeast proteins necessary for cell-surface function of a potassium channel (2007) (54)
Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in S. pombe (2017) (54)
Small molecule cognitive enhancer reverses age-related memory decline in mice (2020) (54)
An Amino-terminal Domain Containing Hydrophobic and Hydrophilic Sequences Binds the Signal Recognition Particle Receptor α Subunit to the β Subunit on the Endoplasmic Reticulum Membrane (*) (1995) (54)
Basic leucine zipper transcription factor Hac1 binds DNA in two distinct modes as revealed by microfluidic analyses (2012) (53)
Fibroblasts and Their Transformations: The Connective-Tissue Cell Family (2002) (52)
Dynamics of co-translational protein targeting. (2015) (52)
Mechanism of protein translocation across the endoplasmic reticulum. (1982) (51)
Structure of the phylogenetically most conserved domain of SRP RNA. (1999) (51)
Seg1 controls eisosome assembly and shape (2012) (50)
Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic (2015) (50)
The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1 (2018) (50)
Evidence for an extended 7SL RNA structure in the signal recognition particle. (1987) (50)
Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1 (2011) (48)
Prepro-carboxypeptidase Y and a truncated form of pre-invertase, but not full-length pre-invertase, can be posttranslationally translocated across microsomal vesicle membranes from Saccharomyces cerevisiae (1988) (48)
Lymphocytes and the Cellular Basis of Adaptive Immunity (2002) (47)
Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response (2020) (47)
Intracellular Compartments and Protein Sorting (2002) (46)
Full-length prepro-alpha-factor can be translocated across the mammalian microsomal membrane only if translation has not terminated (1988) (46)
Translational control by eIF2α phosphorylation regulates vulnerability to the synaptic and behavioral effects of cocaine (2016) (46)
The Adaptive Immune System (2002) (46)
Blood Vessels and Endothelial Cells (2002) (44)
Membrane lysis during biological membrane fusion: collateral damage by misregulated fusion machines (2008) (44)
SRP RNA controls a conformational switch regulating the SRP–SRP receptor interaction (2008) (44)
Structure of the most conserved internal loop in SRP RNA (1999) (44)
Chromosomal DNA and Its Packaging in the Chromatin Fiber (2002) (43)
Intracellular Vesicular Traffic (2002) (42)
Protein targeting to and translocation across the membrane of the endoplasmic reticulum. (1992) (41)
The Innate and Adaptive Immune Systems (2017) (41)
Role of signal recognition particle in the membrane assembly of Sindbis viral glycoproteins. (1984) (41)
Mathematical modeling of the effects of the signal recognition particle on translation and translocation of proteins across the endoplasmic reticulum membrane. (1987) (41)
Heterodimer SRP9/14 is an integral part of the neural BC200 RNP in primate brain (1998) (41)
A conformational RNA zipper promotes intron ejection during non‐conventional XBP1 mRNA splicing (2015) (41)
The signal recognition particle (SRP) RNA links conformational changes in the SRP to protein targeting. (2007) (40)
Delayed Ras/PKA signaling augments the unfolded protein response (2014) (40)
Discrete nascent chain lengths are required for the insertion of presecretory proteins into microsomal membranes (1993) (40)
Structure of the signal recognition particle by electron microscopy. (1985) (39)
Ion Channels and the Electrical Properties of Membranes (2002) (38)
The Golgi-resident protease Kex2 acts in conjunction with Prm1 to facilitate cell fusion during yeast mating (2007) (38)
Signal Recognition Particle-ribosome Binding Is Sensitive to Nascent Chain Length* (2014) (37)
Real-time observation of signal recognition particle binding to actively translating ribosomes (2014) (37)
B Cells and Antibodies (2002) (36)
Structural basis for mobility in the 1.1 A crystal structure of the NG domain of Thermus aquaticus Ffh. (2002) (36)
How Cells Read the Genome: From DNA to Protein (2002) (35)
How Cells Obtain Energy from Food (2002) (35)
Membrane Transport of Small Molecules and the Electrical Properties of Membranes (2002) (35)
Synthesis in vitro and translocation of apolipoprotein AI across microsomal vesicles. (1981) (35)
Studying Gene Expression and Function (2002) (35)
BAX Inhibitor-1 Is a Negative Regulator of the ER Stress Sensor IRE 1 a (2009) (34)
Specificity in endoplasmic reticulum-stress signaling in yeast entails a step-wise engagement of HAC1 mRNA to clusters of the stress sensor Ire1 (2014) (34)
Cytosolic protein translocation factors is SRP still unique? (1989) (34)
Iron affects Ire1 clustering propensity and the amplitude of endoplasmic reticulum stress signaling (2017) (34)
Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether (2019) (34)
Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction (2020) (33)
General Principles of Cell Communication (2002) (33)
8 – The Unfolded Protein Response (2002) (33)
Characterization of the rough endoplasmic reticulum ribosome-binding activity (1991) (33)
mRNA Targeting to ER Stress Signaling Sites (2008) (33)
Quantitative microscopy reveals dynamics and fate of clustered IRE1α (2019) (32)
T Cells and MHC Proteins (2002) (32)
MBOC6 Custom Textbook - University of Toronto - BIO230H (2018) (31)
BAX inhibitor‐1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response (2017) (31)
Inhibition of the integrated stress response by viral proteins that block p-eIF2–eIF2B association (2020) (31)
Pausing to decide. (2000) (31)
Introduction to Pathogens (2002) (31)
IRE1α Disruption in Triple-Negative Breast Cancer Cooperates with Antiangiogenic Therapy by Reversing ER Stress Adaptation and Remodeling the Tumor Microenvironment (2020) (31)
Lipase Maturation Factor LMF1, Membrane Topology and Interaction with Lipase Proteins in the Endoplasmic Reticulum* (2009) (30)
TMBHMM: a frequency profile based HMM for predicting the topology of transmembrane beta barrel proteins and the exposure status of transmembrane residues. (2011) (30)
Ribosome-associated vesicles: A dynamic subcompartment of the endoplasmic reticulum in secretory cells (2020) (30)
Fluorescence-detected assembly of the signal recognition particle: binding of the two SRP protein heterodimers to SRP RNA is noncooperative. (1992) (30)
An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation (2020) (29)
An ultra-high affinity synthetic nanobody blocks SARS-CoV-2 infection by locking Spike 1 into an inactive conformation 2 (2020) (29)
Transport into the Cell from the Plasma Membrane: Endocytosis (2002) (28)
SRP--Where the RNA and Membrane Worlds Meet (2000) (28)
Principles of Membrane Transport (2002) (28)
Electron-Transport Chains and Their Proton Pumps (2002) (28)
C-terminal sequences can inhibit the insertion of membrane proteins into the endoplasmic reticulum of Saccharomyces cerevisiae (1992) (27)
Evidence for peptide transport across microsomal membranes. (1992) (27)
Functional dissection of the signal recognition particle (1987) (27)
X-ray Structures of the Signal Recognition Particle Receptor Reveal Targeting Cycle Intermediates (2007) (27)
Bioinformatics Training Network (BTN): a community resource for bioinformatics trainers (2011) (26)
In vitro protein translocation across microsomal membranes of Saccharomyces cerevisiae. (1991) (26)
The RNA World and the Origins of Life (2002) (26)
Structures of SRP54 and SRP19, the Two Proteins that Organize the Ribonucleic Core of the Signal Recognition Particle from Pyrococcus furiosus (2008) (26)
The Mars1 kinase confers photoprotection through signaling in the chloroplast unfolded protein response (2019) (26)
Secretion requires a cytoplasmically disposed sulphydryl of the RER membrane (1980) (26)
eIF2B conformation and assembly state regulate the integrated stress response (2020) (26)
Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress (2018) (25)
Programmed Cell Death (Apoptosis) (2002) (24)
Basic Genetic Mechanisms (2002) (23)
The Self-Assembly and Dynamic Structure of Cytoskeletal Filaments (2002) (23)
Wild type and mutant signal peptides of Escherichia coli outer membrane lipoprotein interact with equal efficiency with mammalian signal recognition particle. (1987) (23)
Painful Publishing (2008) (23)
Combined chemical–genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma (2016) (23)
The Molecular Basis of Cancer-Cell Behavior (2002) (23)
Protein targeting to and translocation across the membrane of the endoplasmic reticulum (1992) (22)
Transport from the ER through the Golgi Apparatus (2002) (22)
Translocation of a lysosomal enzyme across the microsomal membrane requires signal recognition particle. (1983) (22)
NMR studies of the most conserved RNA domain of the mammalian signal recognition particle (SRP). (1996) (21)
Note to the Reader (1992) (21)
Integrated stress response inhibitor reverses sex-dependent behavioral and cell-specific deficits after mild repetitive head trauma. (2019) (21)
Extracellular Control of Cell Division, Cell Growth, and Apoptosis (2002) (21)
The unfolded protein response in health and disease (2012) (20)
Cassette mutagenic analysis of the yeast invertase signal peptide: effects on protein translocation (1989) (20)
eIF2α-mediated translational control regulates the persistence of cocaine-induced LTP in midbrain dopamine neurons (2016) (20)
From DNA to RNA (2002) (20)
Analyzing Protein Structure and Function (2002) (20)
Reconstitution of protein translocation activity from partially solubilized microsomal vesicles. (1990) (20)
Carrier Proteins and Active Membrane Transport (2002) (20)
DNA Replication Mechanisms (2002) (19)
The use of gene-fusions to determine membrane protein topology in Saccharomyces cerevisiae (1989) (19)
Structures of the Signal Recognition Particle Receptor from the Archaeon Pyrococcus furiosus: Implications for the Targeting Step at the Membrane (2008) (19)
Molecular crosstalk between the nucleotide specificity determinant of the SRP GTPase and the SRP receptor. (2005) (18)
An Overview of the Cell Cycle (2002) (18)
Translational control of nicotine-evoked synaptic potentiation in mice and neuronal responses in human smokers by eIF2α (2016) (18)
Manipulating Proteins, DNA, and RNA (2002) (18)
The stress-sensing domain of activated IRE1α forms helical filaments in narrow ER membrane tubes (2021) (18)
Germ Cells and Fertilization (2002) (17)
Signaling through G-Protein-Linked Cell-Surface Receptors (2002) (17)
From RNA to Protein (2002) (17)
Structural insights into ISRIB, a memory‐enhancing inhibitor of the integrated stress response (2020) (17)
Two receptors act sequentially (1987) (17)
Cell Biology of Infection (2002) (16)
Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α (2021) (16)
tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay (2019) (16)
An ATP-binding membrane protein is required for protein translocation across the endoplasmic reticulum membrane. (1991) (16)
Transport from the Trans Golgi Network to Lysosomes (2002) (16)
The Compartmentalization of Cells (2002) (16)
The protein translocation machinery of the endoplasmic reticulum (1982) (16)
The Cytoskeleton and Cell Behavior (2002) (15)
Histology: The Lives and Deaths of Cells in Tissues (2002) (15)
Msp1/ATAD1 in Protein Quality Control and Regulation of Synaptic Activities. (2020) (15)
Coexpressed subunits of dual genetic origin define a conserved supercomplex mediating essential protein import into chloroplasts (2020) (15)
A Ribosome at the End of the Tunnel (1997) (14)
Neisseria gonorrhoeae PilA Is an FtsY Homolog (1999) (14)
Systematic characterization of gene function in the photosynthetic alga Chlamydomonas reinhardtii (2022) (14)
Ier1 p: A Kinase and Site-Specific Endoribonuclease (2001) (14)
Table 22-1, Blood Cells (2002) (14)
Engineering ER-stress dependent non-conventional mRNA splicing (2018) (14)
Mrx6 regulates mitochondrial DNA copy number in Saccharomyces cerevisiae by engaging the evolutionarily conserved Lon protease Pim1 (2020) (13)
Isolation of a cDNA clone of the 14-kDa subunit of the signal recognition particle by cross-hybridization of differently primed polymerase chain reactions. (1989) (13)
Drosophila and the Molecular Genetics of Pattern Formation: Genesis of the Body Plan (2002) (13)
The Yeast Cell Fusion Protein Prm1p Requires Covalent Dimerization to Promote Membrane Fusion (2010) (13)
DNA Replication, Repair, and Recombination (2002) (13)
Walking Along the Serendipitous Path of Discovery (2010) (13)
The Endoplasmic Reticulum (2002) (13)
Travelling by TRAM (1992) (12)
Cristae-dependent quality control of the mitochondrial genome (2021) (12)
Purification and activity assays of the catalytic domains of the kinase/endoribonuclease Ire1p from Saccharomyces cerevisiae. (2001) (12)
Ire1p: a kinase and site-specific endoribonuclease. (2001) (12)
Structure–Activity Studies of Bis‐O‐Arylglycolamides: Inhibitors of the Integrated Stress Response (2016) (12)
Looking at the Structure of Cells in the Microscope (2002) (12)
A first line of defense against ER stress (2012) (12)
Development of Multicellular Organisms (2002) (11)
The Chemical Components of a Cell (2002) (11)
The Structure and Function of DNA (2002) (11)
Fractionation of Cells (2002) (11)
Predicting where Small Molecules Bind at Protein-Protein Interfaces (2013) (11)
Cell Chemistry and Biosynthesis (2002) (11)
Cells in Their Social Context (2002) (11)
Validation of the Hsp 70-Bag 3 Protein-Protein Interaction as a Potential Therapeutic Target in Cancer (2014) (11)
The Transport of Molecules between the Nucleus and the Cytosol (2002) (11)
Prediction of the Exposure Status of transmembrane beta Barrel residues from protein Sequence (2011) (11)
From symbiont to parasite: the evolution of for-profit science publishing (2019) (10)
Pathogens, Infection, and Innate Immunity (2002) (10)
Genesis, Modulation, and Regeneration of Skeletal Muscle (2002) (10)
Signaling through Enzyme-Linked Cell-Surface Receptors (2002) (10)
Renewal by Multipotent Stem Cells: Blood Cell Formation (2002) (10)
The Evolution of Electron-Transport Chains (2002) (10)
Viral evasion of the integrated stress response through antagonism of eIF2-P binding to eIF2B (2021) (10)
Intracellular Control of Cell-Cycle Events (2002) (9)
BAX inhibitor‐1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response (2021) (9)
Generation of Antibody Diversity (2020) (9)
The protein translocation machinery of the endoplasmic reticulum. (1982) (9)
Caenorhabditis Elegans: Development from the Perspective of the Individual Cell (2002) (9)
Structural and functional basis for RNA cleavage by Ire 1 (2011) (9)
Isolating Cells and Growing Them in Culture (2002) (9)
Cell junctions and the extracellular matrix (2017) (9)
Cancer as a Microevolutionary Process (2002) (9)
Universal Mechanisms of Animal Development (2002) (9)
Gardner the Unfolded Protein Response Unfolded Proteins Are Ire 1-Activating Ligands That Directly Induce (2011) (8)
A GTPase cycle in initiation of protein translocation across the endoplasmic reticulum membrane. (1993) (8)
Epidermis and Its Renewal by Stem Cells (2002) (8)
Title Structures of the signal recognition particle receptor from the Archaeon Pyrococcus furiosus : Implications for the targeting step at the membrane Permalink (2008) (8)
Cell Movements and the Shaping of the Vertebrate Body (2002) (8)
Noncanonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α promotes cancer-cell survival (2021) (8)
Concerted complex assembly and GTPase activation in the chloroplast signal recognition particle. (2011) (8)
Genetic and biochemical analysis of the fission yeast ribonucleoprotein particle containing a homolog of Srp54p (1994) (8)
DNA-Binding Motifs in Gene Regulatory Proteins (2002) (7)
Computational Constraints on Syntactic Processing in a Nonhuman Primate (2004) (7)
Catalysis and the Use of Energy by Cells (2002) (7)
Chloroplasts and Photosynthesis (2002) (7)
Endoplasmic reticulum stress activates human IRE1α through reversible assembly of inactive dimers into small oligomers (2021) (7)
Transport from the Trans Golgi Network to the Cell Exterior: Exocytosis (2002) (7)
eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response. (2019) (7)
Blobel's Nobel A Vision Validated (1999) (7)
The Initiation and Completion of DNA Replication in Chromosomes (2002) (7)
DNA and Chromosomes (2002) (6)
Author response: ER-associated mitochondrial division links the distribution of mitochondria and mitochondrial DNA in yeast (2013) (6)
How Cells Regulate Their Cytoskeletal Filaments (2002) (6)
Systematic characterization of gene function in a photosynthetic organism (2020) (6)
Internal Organization of the Cell (2002) (6)
Protein translocation. Travelling by TRAM. (1992) (6)
Cells and Genomes (2002) (6)
The Genetic Systems of Mitochondria and Plastids (2002) (6)
How Genomes Evolve (2002) (6)
Chapter 11 The role of GTP in protein targeting to the endoplasmic reticulum (1992) (5)
Targeting pathways to the endoplasmic reticulum membrane. (1995) (5)
Components of the Cell-Cycle Control System (2002) (5)
Cancer Treatment: Present and Future (2002) (5)
Genetic Information in Eucaryotes (2002) (5)
The Airways and the Gut (2002) (5)
Isolating, Cloning, and Sequencing DNA (2002) (5)
Primordial Germ Cells and Sex Determination in Mammals (2002) (5)
Regulation of Organelle Biogenesis Review (1996) (4)
Part II Basic Genetic Mechanisms: DNA, Chromosomes, and Genomes (2017) (4)
Olfactory and Vomeronasal Receptor Feedback Employ Divergent Mechanisms of PERK Activation (2018) (4)
Energy Generation in Mitochondria and Chloroplasts (2013) (4)
The Molecular Mechanisms of Membrane Transport and the Maintenance of Compartmental Diversity (2002) (4)
The ribosome talks back (1996) (4)
Assembly of proteins in the endoplasmic reticulum. (1989) (4)
Introduction to the Cell (2002) (3)
The Universal Features of Cells on Earth (2002) (3)
The Mechanics of Cell Division (2002) (3)
Protomer alignment modulates specificity of RNA substrate recognition by Ire1 (2021) (3)
Crystallization of the dimerization-initiation site of genomic HIV-1 RNA: preliminary crystallographic results. (1999) (3)
The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis - eScholarship (2012) (3)
Homeostatic Regulation The Unfolded Protein Response: From Stress Pathway to (2013) (3)
Cell Communities: Tissues, Stem Cells, and Cancer (2013) (3)
Binding sites of the 19-kDa and 68 / 72-kDa signal recognition particle ( SRP ) proteins on SRP RNA as determined by protein-RNA " footprinting " ( a-sarcin / ribonudeoprotein / reconstitution / secretion / targeting ) (3)
Finding the Cancer-Critical Genes (2002) (3)
The Global Structure of Chromosomes (2002) (3)
The fl Subunit of the Signal Recognition Particle Receptor Is a Transmembrane GTPase that Anchors the a Subunit, a Peripheral Membrane GTPase, to the Endoplasmic Reticulum Membrane (2002) (3)
How Genetic Switches Work (2002) (3)
Protein targeting. The ribosome talks back. (1996) (3)
The Diversity of Genomes and the Tree of Life (2002) (3)
An Overview of Gene Control (2002) (3)
Assemb L Ed Polysomes Synthesizing Secretory Protein (3)
From DNA to Protein: How Cells Read the Genome (2013) (3)
Helenius et al. reply (2008) (3)
The Preventable Causes of Cancer (2002) (3)
Intercepting IRE1 kinase‐FMRP signaling prevents atherosclerosis progression (2022) (3)
Berne and Levy Physiology, 7th Edition (2018) (3)
Sequence and structure of Tetrahymena SRP RNA. (1991) (3)
The Maintenance of DNA Sequences (2002) (2)
Signal sequence recognition and protein targeting to the endoplasmic reticulum membrane. (1995) (2)
Author response: eIF2B conformation and assembly state regulate the integrated stress response (2021) (2)
Site-Specific Recombination (2002) (2)
Author response: Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response (2015) (2)
Cell Chemistry and Bioenergetics (2017) (2)
The ABC (Analysing Biomolecular Contacts)-database (2007) (2)
Viral Evasion of the Integrated Stress Response Through Antagonistic eIF2-P Mimicry (2021) (2)
Organogenesis and the Patterning of Appendages (2002) (2)
Crystal structure of the ligase domain of fungal tRNA ligase Trl1 (2019) (2)
Author response: Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch (2016) (2)
Transport Across Cell Membranes (2013) (2)
Stem Cells and Tissue Renewal (2017) (2)
Signaling Pathways That Depend on Regulated Proteolysis (2002) (2)
Visualizing Molecules in Living Cells (2002) (2)
OF PROTEIN TRANSLOCATION ACROSS THE ENDOPLASMIC RETICULUM MEMBRANE (1986) (2)
An unfolded protein-induced conformational switch activates mammalian IRE 1 1 2 (2)
Author response: Pharmacological brake-release of mRNA translation enhances cognitive memory (2013) (2)
Chemical Components of Cells (2013) (2)
Intracellular Membrane Traffic (2017) (2)
A Legionella toxin mimics tRNA and glycosylates the translation machinery to trigger a ribotoxic stress response (2022) (2)
Inhibition of the integrated stress response by viral proteins that block p-eIF2–eIF2B association (2020) (2)
The Molecular Genetic Mechanisms That Create Specialized Cell Types (2002) (2)
Author response: eIF2α-mediated translational control regulates the persistence of cocaine-induced LTP in midbrain dopamine neurons (2016) (1)
Response Endoplasmic Reticulum Stress Sensing in the Unfolded Protein (2013) (1)
Part IV Internal Organization of the Cell: Membrane Structure (2017) (1)
Correction: Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response (2021) (1)
Protein Structure and Function (2013) (1)
Does Rft1 flip an N-glycan lipid precursor?: Reply (2008) (1)
Early Translational Events in the Synthesis of Acetylcholine Receptor (1982) (1)
Part I Introduction to the Cell: Cells and Genomes (2017) (1)
Structure and Function of the Signal Recognition Particle (1986) (1)
Conserved structural elements specialize ATAD1 as a membrane protein extraction machine (2021) (1)
Homeotic Selector Genes and the Patterning of the Anteroposterior Axis (2002) (1)
Title Cofactor-mediated conformational control in the bifunctional kinase / RNase Ire 1 Permalink (2011) (1)
Bioinformatics of Protein-Protein Interfaces and Small Molecule Effectors (2012) (1)
Modern Recombinant DNA Technology (2013) (1)
Science as a Way of Knowing: From Protein Machines to Evidence-Based Decisions (2016) (1)
Pathogens and Infection (2017) (1)
Intracellular Compartments and Protein Transport (2013) (1)
The Membranes of a Eukaryotic Cell (1989) (1)
The SRP-Dependent Protein Targeting Pathway in Saccharomyces Cerevisiae (1993) (1)
Figure 7-87, Possible post-transcriptional controls on gene expression (2002) (1)
A Plasma Membrane EMAP Reveals Links Between the Eisosome , Sphingolipid Metabolism and Endosomal Trafficking (2010) (1)
Two structure papers, a call from Frankfurt airport, and how to escape from reviewer delays: An interview with Peter Walter (2013) (1)
Structural basis of eIF2B-catalyzed GDP exchange and phosphoregulation by the integrated stress response (2018) (1)
In vitro RNA Cleavage Assays to Characterize IRE1-dependent RNA Decay (2019) (1)
A point mutation in the nucleotide exchange factor eIF2B constitutively activates the integrated stress response by allosteric modulation (2021) (1)
Response : "Sequence-Gazing?" (1991) (1)
How Genes and Genomes Evolve (2013) (1)
Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress (2018) (1)
Retraction Notice to: The Unfolded Protein Response Element IRE1α Senses Bacterial Proteins Invading the ER to Activate RIG-I and Innate Immune Signaling. (2018) (1)
Author response: Ceapins inhibit ATF6α signaling by selectively preventing transport of ATF6α to the Golgi apparatus during ER stress (2016) (1)
Regulating ER Protein Folding Homeostasis By Distinctively Processing mRNAs (2018) (0)
Binding sites of the 9- and 14-kilodalton heterodimeric protein subunit of the signal recognition particle (SRP) are contained exclusively in the Alu domain of SRP RNA and contain a sequence motif that is conserved in evolution (1991) (0)
Panel 2-3, The Principal Types of Weak Noncovalent Bonds that Hold Macromolecules Together (2002) (0)
ligase reveals kinetic competition between non-conventional mRNA splicing and mRNA decay. (2019) (0)
Abstract PR06: Systematic genetic interaction maps reveal synthetic-lethal vulnerabilities in leukemia and multiple myeloma (2013) (0)
Msp1-substrate complex in closed conformation (2020) (0)
Figure 2-6, Sodium chloride: an example of ionic bond formation (2002) (0)
Author response: Multiple selection filters ensure accurate tail-anchored membrane protein targeting (2016) (0)
Figure 21-21, Heterochronic mutations in the lin-14 gene of C. elegans. (2002) (0)
Figure 3-26, Actin filaments (2002) (0)
Figure 3-1, A peptide bond (2002) (0)
Author response: The Mars1 kinase confers photoprotection through signaling in the chloroplast unfolded protein response (2019) (0)
Figure 7-52, The nonuniform distribution of four gene regulatory proteins in an early Drosophila embryo (2002) (0)
Figure 23-3, Benign versus malignant tumors (2002) (0)
Figure 6-87, Ubiquitin and the marking of proteins with multiubiquitin chains (2002) (0)
Abstract A43: Opposing roles of the 19S regulatory- and 20S core-proteasomal subunits in controlling sensitivity of multiple myeloma cells to proteasome inhibition. (2015) (0)
Author response: Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether (2019) (0)
Figure 5-9, Exonucleolytic proofreading by DNA polymerase during DNA replication (2002) (0)
Sexual Reproduction and the Power of Genetics (2013) (0)
Figure 19-11, Desmosomes (2002) (0)
Two Cultures and the Revolution in Biotechnology (2004) (0)
Figure 8-51, The yeast two-hybrid system for detecting protein-protein interactions (2002) (0)
Author response: tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay (2019) (0)
Figure 25-49, A natural killer (NK) cell attacking a cancer cell (2002) (0)
Figure 7-99, The importance of the 3′ UTR in localizing mRNAs to specific regions of the cytoplasm (2002) (0)
Figure 8-9, Comparison of velocity sedimentation and equilibrium sedimentation (2002) (0)
Table 2-1, Atomic Characteristics of the Most Abundant Elements in Living Tissues (2002) (0)
Abstract A2-12: Opposing roles of the 19S regulatory and 20S core proteasomal subunits in controlling sensitivity to proteasome inhibitors (2015) (0)
Figure 4-11, The banding patterns of human chromosomes (2002) (0)
Msp1 (E214Q)-substrate complex (2020) (0)
Figure 6-79, Steps in the creation of a functional protein (2002) (0)
Figure 3-22, A protein molecule containing multiple copies of a single protein subunit (2002) (0)
Figure 5-8, The structure of a DNA replication fork (2002) (0)
particle containing a homolog ofSrp54p (1994) (0)
Figure 13-47, Sorting of membrane proteins in the endocytic pathway (2002) (0)
Figure 19-39, The linkage between a GAG chain and its core protein in a proteoglycan molecule (2002) (0)
TRANSPORT OF ANTIGENIC PEPTIDES INTO MICROSOMAL VESICLES (1993) (0)
Figure 8-41, How PCR is used in forensic science (2002) (0)
Substrate requirements for SRP-mediated targeting to the ER membrane (1987) (0)
Signaling in Plants (2002) (0)
Figure 2-55, Energy transfer and the role of activated carriers in metabolism (2002) (0)
Author response: Misfolded proteins bind and activate death receptor 5 to trigger apoptosis during unresolved endoplasmic reticulum stress (2019) (0)
Structure of anti-SARS-CoV-2 Spike nanobody mNb6 (2020) (0)
Figure 24-60, The processing of an extracellular protein antigen for presentation to a helper T cell (2002) (0)
Figure 17-17, The structural basis of Cdk activation (2002) (0)
Figure 6-90, The production of a protein by a eucaryotic cell (2002) (0)
Crystal structure of the oligomer formed by the kinase-ribonuclease domain of Ire1 (2008) (0)
Table 6-3, Inhibitors of Protein or RNA Synthesis (2002) (0)
Figure 15-15, Three classes of cell-surface receptors (2002) (0)
Figure 24-64, The signaling events initiated by the binding of peptide-MHC complexes to T cell receptors (signal 1) (2002) (0)
ResponseReticulum Stress Sensing in the Unfolded Protein (2014) (0)
Ceapins block the unfolded protein response sensor ATF 6 α by inducing a neomorphic 1 inter-organelle tether 2 3 (2019) (0)
Structure of the heterodimer of the conserved GTPase domains of the Signal Recognition Particle (Ffh) and Its Receptor (FtsY) (2004) (0)
Electron cryo-microscopy of the eukaryotic translation initiation factor 2B from Homo sapiens (2018) (0)
Figure 8-25, Different hybridization conditions allow less than perfect DNA matching (2002) (0)
Figure 16-65, Regulated melanosome movements in fish pigment cells (2002) (0)
Figure 14-13, The two components of the electrochemical proton gradient (2002) (0)
Lasker Award Winner Peter Walter (2014) (0)
Abstract PR07: Systematic genetic interaction maps reveal rewiring of the stress response network and resulting vulnerabilities in leukemia and multiple myeloma cells (2013) (0)
Figure 16-54, Myosin superfamily tree (2002) (0)
Figure 2-35, Some of the metabolic pathways and their interconnections in a typical cell (2002) (0)
Figure 1-30, The genome of E. coli. (2002) (0)
Abstract A2-57: Identification of genetic vulnerabilities within the proteostasis network of multiple myeloma (2015) (0)
Figure 9-2, Resolving power (2002) (0)
Abstract A08: Systematic identification of genetic vulnerabilities synergizing with proteasome and IRE1 inhibition in multiple myeloma cells using ultra-complex shRNA libraries (2013) (0)
THE SIGNAL SEQUENCE BINDING PROTEIN FFH FROM THERMUS AQUATICUS (1999) (0)
Figure 6-44, Electron micrograph of a thin section of a nucleolus in a human fibroblast, showing its three distinct zones (2002) (0)
The activated endoplasmic reticulum stress sensor IRE1 oligomerizes into filaments contained in 30 nm membrane tubes of complex topology (2017) (0)
NMR STRUCTURE OF THE MOST CONSERVED RNA MOTIF IN SRP RNA (1999) (0)
Figure 6-20, Superhelical tension in DNA causes DNA supercoiling (2002) (0)
Shedding light on the translocation pore (1993) (0)
Author response: The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis (2012) (0)
1.9 Angstrom Crystal Structure of the Rat VAP-A MSP Homology Domain in Complex with the Rat ORP1 FFAT Motif (2005) (0)
Figure 21-74, Convergent extension and its cellular basis (2002) (0)
Figure 5-56, General recombination in meiosis (2002) (0)
Figure 3-13, Ribbon models of three different protein domains (2002) (0)
Figure 1-18, The structure of a bacterium (2002) (0)
Author response: Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic (2015) (0)
Figure 15-16, Different kinds of intracellular signaling proteins along a signaling pathway from a cell-surface receptor to the nucleus (2002) (0)
Figure 5-31, The proteins that initiate DNA replication in bacteria (2002) (0)
Withdrawal: Lipase maturation factor LMF1, membrane topology and interaction with lipase proteins in the endoplasmic reticulum. (2019) (0)
Author response: Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits (2015) (0)
An Overview of M Phase (2002) (0)
SARS-CoV-2 Spike in complex with neutralizing nanobody Nb6 (2020) (0)
Figure 14-32, The importance of H+-driven transport in bacteria (2002) (0)
A Multilevel Security Scheme based on UNICODE and RGB Color Model using DNA Cryptography (2020) (0)
Activation of Unfolded Protein Response Signaling Pathways During Retinal Degeneration in P23H Rhodopsin Transgenic Rats (2008) (0)
Figure 6-36, The two known classes of self-splicing intron sequences (2002) (0)
Figure 5-29, A replication bubble formed by replication fork initiation (2002) (0)
Sequence andstructure ofTetrahymena SRPRNA (1991) (0)
Structures of SRP54 and SRP19, the two proteins assembling the ribonucleic core of the Signal Recognition Particle from the archaeon Pyrococcus furiosus. (2008) (0)
Author response: Translational control of nicotine-evoked synaptic potentiation in mice and neuronal responses in human smokers by eIF2α (2016) (0)
Part V Cells in Their Social Context: Cancer (2017) (0)
Figure 7-24, Two DNA-binding domains covalently joined by a flexible polypeptide (2002) (0)
Length Binding Is Sensitive to Nascent Chain Signal Recognition Particle-ribosome Cell Biology: (2014) (0)
Figure 2-72, Two pathways for the anaerobic breakdown of pyruvate (2002) (0)
Figure 20-34, The coming together of the sperm and egg pronuclei after mammalian fertilization (2002) (0)
In Vitro Antimyeloma Effects of Inhibitors of the Heat Shock Protein 70 (Hsp70) Molecular Chaperone. (2007) (0)
Figure 12-16, A model for how GTP hydrolysis by Ran provides directionality for nuclear transport (2002) (0)
The Transport of Proteins into Mitochondria and Chloroplasts (2002) (0)
Figure 13-9, The role of dynamin in pinching off clathrin-coated vesicles from the membrane (2002) (0)
Figure 10-45, Simplified diagram of the cell coat (glycocalyx) (2002) (0)
CRYSTAL STRUCTURE OF THE HIV-1 GENOMIC RNA DIMERIZATION INITIATION SITE (1999) (0)
Regulating ER protein homeostasis by differentially processing mRNAs (2020) (0)
Figure 20-3, Haploid and diploid cells in the life cycle of higher and some lower eucaryotes (2002) (0)
Figure 19-12, Focal adhesions (2002) (0)
Figure 19-68, Plant cell walls (2002) (0)
CD46 Is Amplified in High-Risk Myeloma with Gain of Chromosome 1q and Selectively Targeted By a Novel Anti-CD46 Antibody-Drug Conjugate (2016) (0)
Structure of the signal sequence recognition protein, Ffh (1997) (0)
Abstract A2-56: Cancer-specific synthetic lethality and network rewiring elucidated by genetic interaction maps and CRISPR-based gain- and loss-of-function screens (2015) (0)
Figure 8-37, Automated DNA sequencing (2002) (0)
Figure 22-28, The regulatory mechanism controlling blood vessel growth according to a tissue's need for oxygen (2002) (0)
Storing and analysing biomolecular contacts (2011) (0)
Decision letter: Distinct mitochondrial defects trigger the integrated stress response depending on the metabolic state of the cell (2019) (0)
Figure 24-59, Some effects of interferon-γ on infected cells (2002) (0)
A central helical switch controls integrated stress response signaling via eIF2B conformation and assembly. (2023) (0)
1 eIF 2 B Conformation and Assembly State Regulate the Integrated Stress Response 1 (0)
Panel 2-6, A Survey of the Nucleotides (2002) (0)
Peter Walter: investigating how the ER handles secretory proteins. Interview by Sedwick Caitlin. (2011) (0)
Table 2-2, Covalent and Noncovalent Chemical Bonds (2002) (0)
Structure of RNase-inactive point mutant of oligomeric kinase/RNase Ire1 (2011) (0)
Figure 12-38, The smooth ER (2002) (0)
Figure 6-21, Summary of the steps leading from gene to protein in eucaryotes and bacteria (2002) (0)
Figure 18-6, Centriole replication (2002) (0)
Figure 14-29, Redox potential changes along the mitochondrial electron-transport chain (2002) (0)
Author response: Translational control by eIF2α phosphorylation regulates vulnerability to the synaptic and behavioral effects of cocaine (2016) (0)
Figure 9-16, Indirect immuno-cytochemistry (2002) (0)
Ant Ibodies and Complementary Dna Probe (1983) (0)
Figure 7-36, Summary of the mechanisms by which specific gene regulatory proteins control gene transcription in procaryotes (2002) (0)
Targeting Hsp70 in Multiple Myeloma Induces Synergistic Cytotoxicity with Inhibitors of the Proteasome and of Hsp90 (2008) (0)
Figure 12-34, A model for how new peroxisomes are produced (2002) (0)
Figure 23-1, Metastasis (2002) (0)
Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response (2020) (0)
Protomer alignment modulates specificity of RNA substrate 1 recognition by Ire 1 2 3 (2021) (0)
Figure 11-1, The relative permeability of a synthetic lipid bilayer to different classes of molecules (2002) (0)
Figure 17-36, Apoptosis during the metamorphosis of a tadpole into a frog (2002) (0)
Structure of oligomeric kinase/RNase Ire1 in complex with an oligonucleotide (2011) (0)
Figure 25-5, Genetic differences between pathogens and nonpathogens (2002) (0)
Identification of key components involved in mtDNA inheritance during cell division (965.1) (2014) (0)
Figure 12-57, The attachment of a GPI anchor to a protein in the ER (2002) (0)
Multi-Modality Imaging of Multiple Myeloma Bone Disease In Orthotopic Xenograft Models (2010) (0)
Figure 21-118, Transformation of plant architecture by mutation: a comparison of teosinte, normal maize, and tb1-defective maize (2002) (0)
Title Homeostatic adaptation to endoplasmic reticulum stress depends on Ire 1 kinase activity (2011) (0)
AN UNPRECEDENTED VIRAL MECHANISM TO EVADE TRANSLATION INHIBITION INDUCED BY THE INTEGRATED STRESS RESPONSE (2019) (0)
Figure 16-100, The complex architecture of a vertebrate neuron (2002) (0)
Progress torwards the crystal structure of Ffh, the bacterial homolog of SRP54 (1996) (0)
Structures and Conformations in Solution of the Signal Recognition Particle Receptor from the archaeon Pyrococcus furiosus (2008) (0)
Figure 4-43, Polytene chromosomes from C. tentans (2002) (0)
Figure 17-24, The DNA replication checkpoint (2002) (0)
JCB_200811081 1227..1242 (2009) (0)
Figure 17-18, The regulation of Cdk activity by inhibitory phosphorylation (2002) (0)
Figure 14-67, Some of the electron-transport pathways in present-day bacteria (2002) (0)
Günter Blobel (1936–2018) (2018) (0)
The eukaryotic translation initiation factor 2B from Homo sapiens in its apo form (2021) (0)
Isolation andcharacterization ofacDNAclone encoding the19kDaprotein ofsignal recognition particle (SRP): expression andbinding to7SLRNA (1988) (0)
Figure 2-36, Schematic representation of the relationship between catabolic and anabolic pathways in metabolism (2002) (0)
Figure 2-5, Comparison of covalent and ionic bonds (2002) (0)
NMR STRUCTURE OF SRP RNA DOMAIN IV (1999) (0)
ASCB AWARD ESSAY Walking Along the Serendipitous Path of Discovery (2010) (0)
Systematic characterization of gene function in the photosynthetic alga Chlamydomonas reinhardtii (2022) (0)
Figure 21-50, The imaginal discs in the Drosophila larva and the adult structures they give rise to (2002) (0)
N AND GTPASE DOMAINS OF THE SIGNAL SEQUENCE RECOGNITION PROTEIN FFH FROM THERMUS AQUATICUS (1999) (0)
Energy, Catalysis, and Biosynthesis (2013) (0)
Electron cryo-microscopy of the eukaryotic translation initiation factor 2B from Homo sapiens (updated model of PDB ID: 6CAJ) (2021) (0)
Figure 6-38, Some of the major steps in generating the 3′ end of a eucaryotic mRNA (2002) (0)
Part III Ways of Working with Cells: Ways of working with cells (2017) (0)
Abstract C01: Systematic blueprinting of genetic vulnerabilities using ultra-complex shRNA libraries identifies genes synergizing with proteasome inhibition or blockade of IRE1 in multiple myeloma cells (2013) (0)
Figure 10-21, β barrels formed from different numbers of β strands (2002) (0)
The Benefits of Sex (2002) (0)
1.7 Angstrom Crystal Structure of the Rat VAP-A MSP Homology Domain (2005) (0)
Figure 11-21, The gating of ion channels (2002) (0)
Figure 8-54, The DNA footprinting technique (2002) (0)
Figure 7-77, X-inactivation (2002) (0)
Figure 16-35, Filament capping and its effects on filament dynamics (2002) (0)
Differential Effects of Hsp70 Inhibition within the Tumor and Microenvironment in Multiple Myeloma. (2006) (0)
Author response: Real-time observation of signal recognition particle binding to actively translating ribosomes (2014) (0)
Cells: The Fundamental Units of Life (2013) (0)
Figure 23-8, Delayed onset of cancer following exposure to a carcinogen (2002) (0)
HIV-1 subtype A DIS RNA duplex (2004) (0)
Figure 19-73, How the orientation of cellulose microfibrils within the cell wall influences the direction in which the cell elongates (2002) (0)
Figure 14-27, The reaction of O2 with electrons in cytochrome oxidase (2002) (0)
Aberrant cortical spine dynamics after concussive injury are reversed by integrated stress response inhibition (2022) (0)
A central helical fulcrum in eIF2B coordinates allosteric regulation of Integrated Stress Response signaling (2022) (0)

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Molecular Biology of the Cell

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