Peter Wipf
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Most Influential Person Now
American chemistry professor
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Chemistry
Peter Wipf's Degrees
- PhD Chemistry Stanford University
- Masters Chemistry Stanford University
- Bachelors Chemistry University of California, Berkeley
Why Is Peter Wipf Influential?
(Suggest an Edit or Addition)According to Wikipedia, Peter Wipf is a distinguished university professor of chemistry at the University of Pittsburgh. His research interests focus on the total synthesis of natural products, the discovery of new transformations of strained molecules, and the development of new pharmaceuticals. He is a Fellow of the Royal Society of Chemistry , the American Association for the Advancement of Science , and the American Chemical Society .
Peter Wipf's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Nanoparticles in cellular drug delivery. (2009) (793)
- Synthetic Studies of Biologically Active Marine Cyclopeptides (1995) (446)
- Cytochrome c/cardiolipin relations in mitochondria: a kiss of death. (2009) (386)
- Fluorous Synthesis: A Fluorous-Phase Strategy for Improving Separation Efficiency in Organic Synthesis (1997) (350)
- Synthesis of functionalized oxazolines and oxazoles with DAST and Deoxo-Fluor. (2000) (339)
- Targeting mitochondria. (2008) (332)
- Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signaling. (2004) (294)
- Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance. (2009) (282)
- 2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition (2016) (269)
- A common pharmacophore for a diverse set of colchicine site inhibitors using a structure-based approach. (2005) (268)
- Small Molecule Modulators of Endogenous and Co-chaperone-stimulated Hsp70 ATPase Activity* (2004) (203)
- Stochastic voyages into uncharted chemical space produce a representative library of all possible drug-like compounds. (2013) (201)
- A SOLID PHASE PROTOCOL OF THE BIGINELLI DIHYDROPYRIMIDINE SYNTHESIS SUITABLE FOR COMBINATORIAL CHEMISTRY (1995) (199)
- SYNTHETIC APPLICATIONS OF ORGANOCHLOROZIRCONOCENE COMPLEXES (1996) (198)
- A new synthesis of highly functionalized oxazoles (1993) (197)
- Stereochemical control in the ester enolate Claisen rearrangement. 1. Stereoselectivity in silyl ketene acetal formation (1991) (192)
- Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25. (2001) (183)
- Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors. (2002) (176)
- Global lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of acute brain injury (2012) (174)
- Fluorous Synthesis: Fluorous Protocols for the Ugi and Biginelli Multicomponent Condensations. (1997) (164)
- Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. (2007) (159)
- The phosphatidylinositol-3-kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non–small cell lung cancer xenografts (2005) (154)
- TargetHunter: An In Silico Target Identification Tool for Predicting Therapeutic Potential of Small Organic Molecules Based on Chemogenomic Database (2013) (150)
- Metamorphic enzyme assembly in polyketide diversification (2009) (150)
- Mitochondrial‐derived reactive oxygen species (ROS) play a causal role in aging‐related intervertebral disc degeneration (2013) (147)
- Binding of a small molecule at a protein-protein interface regulates the chaperone activity of hsp70-hsp40. (2010) (146)
- Mitochondrial targeting of selective electron scavengers: synthesis and biological analysis of hemigramicidin-TEMPO conjugates. (2005) (144)
- Mitochondria as a target in treatment (2010) (142)
- Chemistry and biology of wortmannin. (2005) (141)
- A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis (2016) (134)
- Dual-specificity phosphatases as targets for antineoplastic agents (2002) (134)
- An experimental survey of the transition between two-state and downhill protein folding scenarios (2008) (128)
- Potent and Selective Disruption of Protein Kinase D Functionality by a Benzoxoloazepinolone* (2008) (126)
- A short, stereospecific synthesis of dihydrooxazoles from serine and threonine derivatives (1992) (124)
- Synthesis of peptide thiazolines from β-hydroxythioamides. An investigation of racemization in cyclodehydration protocols (1994) (122)
- Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum. (2009) (122)
- Zirconocene−Zinc Transmetalation and in Situ Catalytic Asymmetric Addition to Aldehydes (1998) (116)
- Mitochondrial targeting of electron scavenging antioxidants: Regulation of selective oxidation vs random chain reactions. (2009) (114)
- Water-accelerated organic transformations (2001) (114)
- Targeting of XJB-5-131 to mitochondria suppresses oxidative DNA damage and motor decline in a mouse model of Huntington's disease. (2012) (114)
- Total synthesis of (±)-cycloclavine and (±)-5-epi-cycloclavine. (2011) (113)
- A Precursor-specific Role for Hsp40/Hsc70 during Tail-anchored Protein Integration at the Endoplasmic Reticulum* (2008) (111)
- Formal Total Synthesis of (+)-Diepoxin σ (2000) (110)
- Asymmetric total syntheses of tuberostemonine, didehydrotuberostemonine, and 13-epituberostemonine. (2005) (103)
- SN2'-Reactions of Peptide Aziridines. A Cuprate-Based Approach to (E)-Alkene Isosteres (1994) (103)
- Development of a 384-well colorimetric assay to quantify hydrogen peroxide generated by the redox cycling of compounds in the presence of reducing agents. (2008) (102)
- Preparation of allylic alcohols by alkene transfer from zirconium to zinc (1994) (102)
- Inhibition of Metalloprotease Botulinum Serotype A from a Pseudo-peptide Binding Mode to a Small Molecule That Is Active in Primary Neurons* (2007) (101)
- The chiroptical signature of achiral metal clusters induced by dissymmetric adsorbates. (2006) (101)
- Protein kinase D as a potential new target for cancer therapy. (2010) (100)
- Contribution of a solute's chiral solvent imprint to optical rotation. (2007) (100)
- Methyl- and (Trifluoromethyl)alkene Peptide Isosteres: Synthesis and Evaluation of Their Potential as beta-Turn Promoters and Peptide Mimetics. (1998) (99)
- Atomic contributions to the optical rotation angle as a quantitative probe of molecular chirality. (1998) (99)
- Rapid Carboalumination of Alkynes in the Presence of Water (1993) (99)
- Total Synthesis of the Enantiomer of the Antiviral Marine Natural Product Hennoxazole A (1995) (97)
- FROM AZIRIDINES TO OXAZOLINES AND THIAZOLINES : THE HETEROCYCLIC ROUTE TO THIANGAZOLE (2004) (97)
- Synthesis and biological evaluation of the first pentafluorosulfanyl analogs of mefloquine. (2009) (96)
- Discovery and Validation of a New Class of Small Molecule Toll-Like Receptor 4 (TLR4) Inhibitors (2013) (95)
- An investigation of the mitsunobu reaction in the preparation of peptide oxazolines, thiazolines, and aziridines (1992) (95)
- Growth Arrest by the Antitumor Steroidal Lactone Withaferin A in Human Breast Cancer Cells Is Associated with Down-regulation and Covalent Binding at Cysteine 303 of β-Tubulin* (2013) (95)
- Dual specificity protein phosphatases: therapeutic targets for cancer and Alzheimer's disease. (2005) (94)
- Asymmetric Total Synthesis of the Stemona Alkaloid (-)-Stenine (1995) (92)
- Theory-Assisted Determination of Absolute Stereochemistry for Complex Natural Products via Computation of Molar Rotation Angles (1998) (92)
- Antimyeloma Effects of the Heat Shock Protein 70 Molecular Chaperone Inhibitor MAL3-101 (2011) (90)
- Profiling the NIH Small Molecule Repository for compounds that generate H2O2 by redox cycling in reducing environments. (2010) (90)
- Novel protein kinase D inhibitors cause potent arrest in prostate cancer cell growth and motility (2010) (90)
- Dimethylzinc-mediated additions of alkenylzirconocenes to aldimines. New methodologies for allylic amine and C-cyclopropylalkylamine syntheses. (2003) (89)
- Hemigramicidin-TEMPO conjugates: novel mitochondria-targeted antioxidants. (2007) (86)
- Stereochemical control in the ester enolate Claisen rearrangement. 2. Chairlike vs boatlike transition-state selection (1991) (85)
- A General Strategy for Five-Membered Heterocycle Synthesis by Cycloelimination of Alkynyl Ketones, Amides, and Thioamides. (1998) (84)
- Conformational Studies and Structure−Activity Analysis of Lissoclinamide 7 and Related Cyclopeptide Alkaloids (1998) (84)
- A practical method for oxazole synthesis by cycloisomerization of propargyl amides. (2004) (84)
- Solvent effect on optical rotation: A case study of methyloxirane in water. (2006) (82)
- Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation. (2008) (81)
- Mitochondria-targeted disruptors and inhibitors of cytochrome c/cardiolipin peroxidase complexes: a new strategy in anti-apoptotic drug discovery. (2009) (81)
- Treatment With a Novel Hemigramicidin-TEMPO Conjugate Prolongs Survival in a Rat Model of Lethal Hemorrhagic Shock (2007) (81)
- Redox Regulation of Cdc25B by Cell-Active Quinolinediones (2005) (79)
- Total synthesis and revision of stereochemistry of the marine metabolite trunkamide A. (2000) (79)
- Hemigramicidin-TEMPO conjugates: novel mitochondria-targeted anti-oxidants. (2007) (79)
- Structural Requirements for Optimized Delivery, Inhibition of Oxidative Stress, and Antiapoptotic Activity of Targeted Nitroxides (2007) (78)
- Oxidative lipidomics of hyperoxic acute lung injury: mass spectrometric characterization of cardiolipin and phosphatidylserine peroxidation. (2010) (78)
- Polyketide decarboxylative chain termination preceded by o-sulfonation in curacin a biosynthesis. (2009) (78)
- A mitochondria-targeted nitroxide/hemigramicidin S conjugate protects mouse embryonic cells against gamma irradiation. (2008) (77)
- An improved protocol for azole synthesis with PEG-supported Burgess reagent (1996) (76)
- Solid-Phase Synthesis of Peptide Mimetics with (E)-Alkene Amide Bond Replacements Derived from Alkenylaziridines (1997) (76)
- A targeted library of small-molecule, tyrosine, and dual-specificity phosphatase inhibitors derived from a rational core design and random side chain variation. (1997) (76)
- General solution to the synthesis of N-2-substituted 1,2,3-triazoles. (2010) (76)
- Electrostatic versus steric effects in peptidomimicry: synthesis and secondary structure analysis of gramicidin S analogues with (E)-alkene peptide isosteres. (2005) (76)
- A New Thiazole Synthesis by Cyclocondensation of Thioamides and Alkynyl(Aryl)Iodonium Reagents. (1996) (76)
- Ferroptosis as a Novel Therapeutic Target for Friedreich’s Ataxia (2019) (75)
- Total synthesis of (-)-disorazole C1. (2004) (75)
- Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging (2018) (75)
- Total Synthesis and Assignment of Configuration of Lissoclinamide 7 (1996) (73)
- Total synthesis and structure assignment of the antitumor antibiotic aranorosin (1993) (73)
- Thiolysis of oxazolines: A new, selective method for the direct conversion of peptide oxazolines into thiazolines (1995) (72)
- Studies on the synthesis of Stemona alkaloids; stereoselective preparation of the hydroindole ring system by oxidative cyclization of tyrosine (1992) (72)
- Novel applications of alkenyl zirconocenes. (2002) (71)
- Chemical induction of Hsp70 reduces α-synuclein aggregation in neuroglioma cells. (2013) (71)
- Optical Rotation Computation, Total Synthesis, and Stereochemistry Assignment of the Marine Natural Product Pitiamide A (2000) (70)
- Total synthesis of (-)-tuberostemonine. (2002) (70)
- Discovery and Characterization of Novel Small Molecule Inhibitors of Human Cdc25B Dual Specificity Phosphatase (2004) (70)
- Synthesis and biological evaluation of synthetic viridins derived from C(20)-heteroalkylation of the steroidal PI-3-kinase inhibitor wortmannin. (2004) (70)
- Allylic Amines as Key Building Blocks in the Synthesis of (E)-Alkene Peptide Isosteres. (2012) (69)
- The human milk oligosaccharides 2’-Fucosyllactose and 6’-Sialyllactose protect against the development of necrotizing enterocolitis by inhibiting Toll-Like Receptor 4 signaling. (2020) (68)
- Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators (2011) (68)
- Mitochondria-targeted ROS scavenger improves post-ischemic recovery of cardiac function and attenuates mitochondrial abnormalities in aged rats. (2014) (68)
- Synthesis and Biological Evaluation of a Focused Mixture Library of Analogues of the Antimitotic Marine Natural Product Curacin A (2000) (67)
- Terminal Alkene Formation by the Thioesterase of Curacin A Biosynthesis (2011) (67)
- Synthesis and biological evaluation of structurally highly modified analogues of the antimitotic natural product curacin A. (2002) (67)
- Molecular pharmacology and antitumor activity of palmarumycin-based inhibitors of thioredoxin reductase (2006) (66)
- Plasmodium falciparum encodes a single cytosolic type I Hsp40 that functionally interacts with Hsp70 and is upregulated by heat shock (2011) (65)
- Microbial and chemical transformation studies of the bioactive marine sesquiterpenes (S)-(+)-curcuphenol and -curcudiol isolated from a deep reef collection of the Jamaican sponge Didiscus oxeata. (2002) (65)
- Total synthesis of westiellamide (1992) (63)
- 7.2 – Claisen Rearrangements (1991) (62)
- Two strategies for the development of mitochondrion-targeted small molecule radiation damage mitigators. (2011) (62)
- Structure reassignment of the fungal metabolite TAEMC161 as the phytotoxin viridiol. (2003) (61)
- Optical signatures of molecular dissymmetry: combining theory with experiments to address stereochemical puzzles. (2009) (61)
- Identification of Potent Chemotypes Targeting Leishmania major Using a High-Throughput, Low-Stringency, Computationally Enhanced, Small Molecule Screen (2009) (60)
- Structure–activity and High‐content Imaging Analyses of Novel Tubulysins (2007) (59)
- Ring-strain-enabled reaction discovery: new heterocycles from bicyclo[1.1.0]butanes. (2015) (59)
- Pharmacological mitigation of tissue damage during brain microdialysis. (2013) (59)
- A cell-active inhibitor of mitogen-activated protein kinase phosphatases restores paclitaxel-induced apoptosis in dexamethasone-protected cancer cells (2008) (57)
- Transition-metal-mediated cascade reactions: C,C-dicyclopropylmethylamines by way of double C,C-sigma-bond insertion into bicyclobutanes. (2003) (57)
- Enantioselective Synthesis and Photoracemization Studies of (+)-2-Cyclopropyl-7,8-dimethoxy-2H- chromene-5-carboxylic Acid Methyl Ester, an Advanced Intermediate of a Dihydrofolate Reductase Inhibitor. (1999) (57)
- Dimethylzinc-Mediated Addition of Alkenylzirconocenes to α-Keto and α-Imino Esters (2003) (56)
- Chemistry and biology of curacin A. (2004) (56)
- Total synthesis and stereochemical revision of (+)-aeruginosin 298-A. (2000) (56)
- Total Synthesis of the Antimitotic Marine Natural Product (+)-Curacin A. (1996) (56)
- Photoactivated tungsten hexacarbonyl-catalyzed conversion of alkynols to glycals. (2003) (55)
- Total synthesis of N14-desacetoxytubulysin H. (2007) (54)
- Selective carbon–carbon bond formations with alkenylzirconocenes (2004) (54)
- Cell-active dual specificity phosphatase inhibitors identified by high-content screening. (2003) (53)
- Structural and Conformational Dependence of Optical Rotation Angles (1999) (53)
- Optical rotation of noncovalent aggregates. (2003) (52)
- Targeting Mitochondrial Oxidative Stress to Mitigate UV-Induced Skin Damage (2018) (52)
- Transmetalation Reactions in Organocopper Chemistry (1993) (52)
- Natural product based inhibitors of the thioredoxin-thioredoxin reductase system. (2004) (52)
- ATF4 Regulates CD4+ T Cell Immune Responses through Metabolic Reprogramming (2018) (51)
- Transmetalation reactions of alkylzirconocenes: copper-catalyzed conjugate addition to enones (1991) (51)
- Convergent approach to (E)-alkene and cyclopropane peptide isosteres. (2005) (51)
- Titanocene(III)-catalyzed formation of indolines and azaindolines. (2008) (51)
- Determining absolute configuration in flexible molecules: a case study. (2001) (51)
- p97: An Emerging Target for Cancer, Neurodegenerative Diseases and Viral Infections. (2020) (50)
- Rhodium(I)-catalyzed cycloisomerizations of bicyclobutanes. (2008) (50)
- Synthesis and applications of fluorous silyl protecting groups with improved acid stability (1999) (50)
- Synthesis of an 8-pentafluorosulfanyl analog of the antimalarial agent mefloquine (2010) (50)
- Synthesis of Peptides Containing α,α‐Disubstituted α‐Amino Acids by the Azirine/Oxazolone Method: The (12–20)‐Nonapeptide of the Ionophore Alamethicin (1990) (50)
- The mitochondria-targeted nitroxide JP4-039 augments potentially lethal irradiation damage repair. (2009) (49)
- Inhibition of Simian Virus 40 replication by targeting the molecular chaperone function and ATPase activity of T antigen. (2009) (48)
- Synthetic studies toward diazonamide A. Preparation of the benzofuranone-indolyloxazole fragment (1998) (48)
- Copper-catalyzed conjugate additions of organozirconocenes. Synthetic and mechanistic studies. (1994) (48)
- Design, Synthesis, and Biological Evaluation of PKD Inhibitors (2011) (48)
- Small molecule inhibitors of dual specificity protein phosphatases (2000) (48)
- Water/MAO Acceleration of the Zirconocene-Catalyzed Asymmetric Methylalumination of α-Olefins (2000) (48)
- Structure-Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97. (2015) (47)
- Protein Kinase D as a Potential Chemotherapeutic Target for Colorectal Cancer (2014) (47)
- TOTAL SYNTHESIS OF (-)-THIANGAZOLE AND STRUCTURALLY RELATED POLYAZOLES (1995) (47)
- Novel benzofuran inhibitors of human mitogen-activated protein kinase phosphatase-1. (2006) (47)
- Parallel synthesis of oxazolines and thiazolines by tandem condensation-cyclodehydration of carboxylic acids with amino alcohols and aminothiols. (2002) (47)
- Nanoassembly of surfactants with interfacial drug-interactive motifs as tailor-designed drug carriers. (2013) (47)
- Total synthesis of cyclotheonamide A (1993) (47)
- Metal Complexes of Marine Peptide Metabolites: A Novel Ag4 Cluster (1994) (46)
- Evaluating β-turn mimics as β-sheet folding nucleators (2009) (46)
- Mitochondria-targeted antioxidant preserves contractile properties and mitochondrial function of skeletal muscle in aged rats (2015) (46)
- Chrysophaentins are competitive inhibitors of FtsZ and inhibit Z-ring formation in live bacteria. (2013) (46)
- The HSP70 Modulator MAL3-101 Inhibits Merkel Cell Carcinoma (2014) (46)
- Deciphering of Mitochondrial Cardiolipin Oxidative Signaling in Cerebral Ischemia-Reperfusion (2015) (45)
- Structure-activity relationships amongst 4-position quinoline methanol antimalarials that inhibit the growth of drug sensitive and resistant strains of Plasmodium falciparum. (2010) (45)
- SYNTHESIS AND APPLICATIONS OF A FLUOROUS THP PROTECTIVE GROUP (1999) (45)
- Evaluation of mitochondrial bioenergetics, dynamics, endoplasmic reticulum-mitochondria crosstalk, and reactive oxygen species in fibroblasts from patients with complex I deficiency (2018) (45)
- A formal total synthesis of leucascandrolide A. (2002) (45)
- Independent Mechanistic Inhibition of Cdc25 Phosphatases by a Natural Product Caulibugulone (2007) (44)
- Pharmacophore-guided lead optimization: the rational design of a non-zinc coordinating, sub-micromolar inhibitor of the botulinum neurotoxin serotype a metalloprotease. (2009) (44)
- Synthesis of oxazines and thiazines by cyclodehydration of hydroxy amides and thioamides (1998) (44)
- Total Synthesis of (-)-Muscoride A. (1996) (44)
- Synthesis of the tubuvaline-tubuphenylalanine (Tuv-Tup) fragment of tubulysin. (2004) (43)
- Three-component aldimine addition--cyclopropanation. an efficient new methodology for amino cyclopropane synthesis. (2001) (43)
- New inhibitors of the thioredoxin-thioredoxin reductase system based on a naphthoquinone spiroketal natural product lead. (2001) (43)
- Synthetic studies toward diazonamide A. A novel approach for polyoxazole synthesis. (2001) (43)
- Stereospecific synthesis of peptide analogs with allo-threonine and D-allo-threonine residues (1993) (43)
- Synthesis and Evaluation of Potent KCNQ2/3-Specific Channel Activators (2016) (43)
- Diels–Alder approaches to ring-functionalized cyclic β-amino acids (2000) (43)
- Transmetalation reactions of alkenylalanes: copper-catalyzed conjugate addition to enones (1992) (42)
- Organozirconocenes in organic synthesis: tandem epoxide rearrangement-carbonyl addition (1993) (41)
- New peroxylactones from the Jamaican sponge Plakinastrella onkodes, with inhibitory activity against the AIDS opportunistic parasitic infection Toxoplasma gondii (2001) (41)
- .pi.-Facial Selectivity in Nucleophilic Additions to 4,4-Disubstituted Dienones: Experimental Support for Electrostatic Control (1994) (40)
- Large-scale asymmetric synthesis of the bioprotective agent JP4-039 and analogs. (2011) (40)
- Intraesophageal administration of GS-nitroxide (JP4-039) protects against ionizing irradiation-induced esophagitis. (2010) (39)
- Isolation, biology and chemistry of the disorazoles: new anti-cancer macrodiolides. (2009) (39)
- Contributions of academic laboratories to the discovery and development of chemical biology tools. (2013) (39)
- Combinatorial synthesis and biological evaluation of library of small-molecule Ser/Thr-protein phosphatase inhibitors. (1997) (39)
- Total synthesis of the putative structure of the marine metabolite trunkamide A (1999) (39)
- Total synthesis and structure validation of (+)-bistramide C. (2005) (39)
- Mitochondrial energetics is impaired in very long-chain acyl-CoA dehydrogenase deficiency and can be rescued by treatment with mitochondria-targeted electron scavengers (2018) (39)
- Total synthesis of a stereoisomer of bistramide C and assignment of configuration of the natural product. (2002) (39)
- Origins of the high 14-helix propensity of cyclohexyl-rigidified residues in beta-peptides. (2007) (39)
- Photochemical Flow Reactions (2014) (38)
- Reversible thiazolidine exchange: a new reaction suitable for dynamic combinatorial chemistry. (2009) (38)
- Genetically encoded redox sensor identifies the role of ROS in degenerative and mitochondrial disease pathogenesis (2012) (38)
- Carboalumination of 1-alkynes and in situ transmetalation to higher order cyanocuprates. Stereospecific synthesis of tri- and disubstituted olefins by conjugate addition to enones (1990) (38)
- Computational design, synthesis and biological evaluation of para-quinone-based inhibitors for redox regulation of the dual-specificity phosphatase Cdc25B. (2008) (38)
- Transmetalation reactions of organosamarium reagents. Chlorosilane-accelerated copper-catalyzed conjugate additions (1993) (38)
- Elucidating Mitochondrial Electron Transport Chain Supercomplexes in the Heart During Ischemia-Reperfusion. (2016) (38)
- Photooxygenation of an amino-thienopyridone yields a more potent PTP4A3 inhibitor. (2016) (37)
- Water-accelerated tandem Claisen rearrangement-catalytic asymmetric carboalumination. (2001) (37)
- Radiobiologic effects of GS-nitroxide (JP4-039) on the hematopoietic syndrome. (2011) (37)
- Synthesis of the C(1)-C(18) segment of lophotoxin and pukalide. Control of 2-alkenylfuran (E/Z)-configuration. (2002) (37)
- Conjugate addition reactions of organosamarium species via in situ transmetalation to copper(I) salts (1992) (37)
- Mitochondrial targeting of XJB-5-131 attenuates or improves pathophysiology in HdhQ150 animals with well-developed disease phenotypes. (2016) (37)
- Tandem zirconocene homologation-aldimine allylation. (2001) (37)
- Development and implementation of a 384-well homogeneous fluorescence intensity high-throughput screening assay to identify mitogen-activated protein kinase phosphatase-1 dual-specificity protein phosphatase inhibitors. (2007) (36)
- NAD(P)H:Quinone Oxidoreductase-1-Dependent and -Independent Cytotoxicity of Potent Quinone Cdc25 Phosphatase Inhibitors (2004) (36)
- Synthesis and applications of a highly fluorous alkoxy ethyl ether protective group (1999) (36)
- t-BuOOH induces ferroptosis in human and murine cell lines (2018) (36)
- Three-component synthesis of alpha,beta-cyclopropyl-gamma-amino acids. (2005) (36)
- Expedient synthesis of the alpha-C-glycoside analogue of the immunostimulant galactosylceramide (KRN7000). (2006) (36)
- Combinatorial chemistry and contemporary pharmacology. (2000) (36)
- Cdc25B dual-specificity phosphatase inhibitors identified in a high-throughput screen of the NIH compound library. (2009) (35)
- Density functional theory calculation of 13C NMR shifts of diazaphenanthrene alkaloids: reinvestigation of the structure of samoquasine A. (2008) (35)
- SD-208, a Novel Protein Kinase D Inhibitor, Blocks Prostate Cancer Cell Proliferation and Tumor Growth In Vivo by Inducing G2/M Cell Cycle Arrest (2015) (35)
- Diversity-oriented synthesis of azaspirocycles. (2004) (35)
- Total synthesis, biosynthesis and biological profiles of clavine alkaloids. (2016) (35)
- Synthesis and Structure-Activity Relationships of Benzothienothiazepinone Inhibitors of Protein Kinase D. (2011) (34)
- Trisubstituted (E)-alkene dipeptide isosteres as beta-turn promoters in the gramicidin S cyclodecapeptide scaffold. (2006) (34)
- Evaluation of a Novel Calcium Channel Agonist for Therapeutic Potential in Lambert–Eaton Myasthenic Syndrome (2013) (33)
- Synthesis and biological evaluation of caulibugulones A-E. (2004) (33)
- Synthesis of the C(1')--C(11') segment of leucascandrolide A. (2001) (33)
- Eight-Step Enantioselective Total Synthesis of (-)-Cycloclavine. (2017) (33)
- Three‐Dimensional Database Mining Identifies a Unique Chemotype that Unites Structurally Diverse Botulinum Neurotoxin Serotype A Inhibitors in a Three‐Zone Pharmacophore (2008) (33)
- Synaptic Pathophysiology and Treatment of Lambert-Eaton Myasthenic Syndrome (2015) (33)
- Stereoselective synthesis of the functionalized spirocyclic core of aranorosin (1993) (32)
- Faculty Opinions recommendation of Heat shock factor 1 attenuates 4-Hydroxynonenal-mediated apoptosis: critical role for heat shock protein 70 induction and stabilization of Bcl-XL. (2007) (32)
- Synthesis of analogs of the radiation mitigator JP4-039 and visualization of BODIPY derivatives in mitochondria. (2013) (32)
- Synthesis and biological evaluation of 3-aminoisoquinolin-1(2H)-one based inhibitors of the dual-specificity phosphatase Cdc25B. (2015) (32)
- Synthesis and biological evaluation of deoxypreussomerin A and palmarumycin CP1 and related naphthoquinone spiroketals (2001) (32)
- Synthesis of 2‐Hydrazolyl‐4‐Thiazolidinones Based on Multicomponent Reactions and Biological Evaluation Against Trypanosoma Cruzi (2011) (32)
- Total Synthesis of (±)-Nisamycin. (1999) (31)
- A new ligand scaffold for catalytic asymmetric alkylzinc additions to aldehydes. (2002) (31)
- Nucleophilic additions to 4,4-disubstituted 2,5-cyclohexadienones: can dipole effects control facial selectivity? (1999) (31)
- Anti-malarial activity of a non-piperidine library of next-generation quinoline methanols (2010) (31)
- Structural basis of functional group activation by sulfotransferases in complex metabolic pathways. (2012) (30)
- Thiophilic ring-opening and rearrangement reactions of epoxyketone natural products. (1998) (30)
- Toward a Molecular Understanding of the Interaction of Dual Specificity Phosphatases with Substrates: Insights from Structure-Based Modeling and High Throughput Screening (2008) (30)
- Small molecule targeting of PTPs in cancer. (2017) (30)
- A new synthesis of α-methylserine by nucleophilic ring-opening of N-sulfonyl aziridines☆ (1995) (30)
- A Pregnane X Receptor Agonist with Unique Species-Dependent Stereoselectivity and Its Implications in Drug Development (2005) (30)
- Transition-metal-mediated cascade reactions: the water-accelerated carboalumination-Claisen rearrangement-carbonyl addition reaction. (2005) (30)
- Microwave assisted tandem reactions for the synthesis of 2-hydrazolyl-4-thiazolidinones. (2009) (30)
- Synthesis of Cyclopeptide Alkaloids by Cyclooligomerization of Dipeptidyl Oxazolines (2000) (29)
- Intraoral Mitochondrial-Targeted GS-Nitroxide, JP4-039, Radioprotects Normal Tissue in Tumor-Bearing Radiosensitive Fancd2–/– (C57BL/6) Mice (2016) (29)
- Microtubule Binding and Disruption and Induction of Premature Senescence by Disorazole C1 (2009) (29)
- Microwave promoted oxazole synthesis: Cyclocondensation cascade of oximes and acyl chlorides (2005) (29)
- Silver(I)-Catalyzed Addition of Zirconocenes to Glycal Epoxides. A New Synthesis of α-C-Glycosides (2005) (29)
- Identification of new Cdc25 dual specificity phosphatase inhibitors in a targeted small molecule array. (2000) (29)
- Synthesis of homoallylic amines by hydrozirconation-imine addition of allenes. (2005) (29)
- Efficient Synthesis of 1,4-Dihydro-2H-isoquinoline-3,5,8-triones via Cyclobutene Ring Expansion. (1999) (29)
- Synthesis of the 3-aza-[7]-paracyclophane core of haouamine A and B. (2006) (29)
- Radiologic Differences between Bone Marrow Stromal and Hematopoietic Progenitor Cell Lines from Fanconi Anemia (Fancd2–/–) Mice (2014) (29)
- A Topical Mitochondria-Targeted Redox-Cycling Nitroxide Mitigates Oxidative Stress-Induced Skin Damage. (2017) (29)
- Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway. (2016) (28)
- Maternal aryl hydrocarbon receptor activation protects newborns against necrotizing enterocolitis (2021) (28)
- Development of an Undergraduate Course in Chemical Laboratory Safety through an Academic/Industrial Collaboration (2018) (28)
- Copper(I)-catalysed asymmetric conjugate addition of organozirconocenes to N-acyl oxazolidinones (1996) (28)
- Water-Accelerated Organometallic Chemistry: Alkyne Carboalumination - Sulfinimine Addition and Asymmetric Synthesis of Allylic Amines (2002) (28)
- Is Cdc25 a druggable target? (2008) (28)
- 5-Hydroxyindoles by intramolecular alkynol-furan diels-alder cycloaddition. (2013) (28)
- Formation of Nine-Membered Lactams by Oxidative Ring Expansion of 4-Hydroxyhydroindoles: A Biomimetic Approach toward the Tuberostemonone Ring System? (1999) (28)
- Total synthesis of (-)-sessilifoliamide C and (-)-8-epi-stemoamide. (2011) (28)
- Correction to Targeting Mitochondria (2012) (27)
- Pericyclic cascade reactions of (bicyclo[1.1.0]butylmethyl)amines. (2006) (27)
- Use of a masked aldol unit in the synthesis of the right side of FK-506 (1990) (27)
- Peroxisome proliferator-activated receptor γ agonist pioglitazone prevents the hyperglycemia caused by phosphatidylinositol 3-kinase pathway inhibition by PX-866 without affecting antitumor activity (2009) (27)
- Bridged tetrahydroisoquinolines as selective NADPH oxidase 2 (Nox2) inhibitors. (2013) (27)
- Relaxin‐2 therapy reverses radiation‐induced fibrosis and restores bladder function in mice (2018) (27)
- HCS campaign to identify selective inhibitors of IL-6-induced STAT3 pathway activation in head and neck cancer cell lines. (2015) (27)
- Targeting ovarian cancer and endothelium with an allosteric PTP4A3 phosphatase inhibitor (2017) (26)
- Studies directed towards the total synthesis of FK-506 preparation of a C(1) to C(15) segment (1989) (26)
- Antimitotic actions of a novel analog of the fungal metabolite palmarumycin CP1. (2001) (26)
- Total Synthesis of Palmarumycin CP1 and (±)-Deoxypreussomerin A (1998) (26)
- Transmetalation reactions of organozirconocenes : a general, selective, and facile synthesis of ketones from acid chlorides (1992) (26)
- Fluorous parallel synthesis of a piperazinedione-fused tricyclic compound library. (2009) (26)
- A microwave assisted intramolecular-furan-Diels-Alder approach to 4-substituted indoles. (2008) (26)
- Zirconocene-catalyzed epoxy ester - ortho ester rearrangement: A new method for the protection of polyfunctionalized carboxylic acids and the asymmetric synthesis of ortho esters (1997) (26)
- Peptide-Like Molecules (PLMs): A Journey from Peptide Bond Isosteres to Gramicidin S Mimetics and Mitochondrial Targeting Agents. (2009) (26)
- Total synthesis of (-)-CP2-disorazole C1. (2011) (25)
- Synthesis of chemoreversible prodrugs of ara-C with variable time-release profiles. Biological evaluation of their apoptotic activity. (1996) (25)
- New Pyrazolopyrimidine Inhibitors of Protein Kinase D as Potent Anticancer Agents for Prostate Cancer Cells (2013) (25)
- Selenosemicarbazones as potent cruzipain inhibitors and their antiparasitic properties against Trypanosoma cruzi (2012) (25)
- Development and Implementation of a High-Throughput High-Content Screening Assay to Identify Inhibitors of Androgen Receptor Nuclear Localization in Castration-Resistant Prostate Cancer Cells. (2016) (25)
- Synthesis of anti-inflammatory α-and β-linked acetamidopyranosides as inhibitors of toll-like receptor 4 (TLR4). (2015) (25)
- Residue Preference Mapping of Ligand Fragments in the Protein Data Bank (2011) (24)
- Perfluorooctane sulfonate (PFOS) produces dopaminergic neuropathology in C. elegans. (2019) (24)
- An uncharged oxetanyl sulfoxide as a covalent modifier for improving aqueous solubility. (2014) (24)
- Long‐Range Electrostatic Effects in Synthesis: Dipole‐Controlled Nucleophilic Addition to a Naphthoquinone Acetal in Model Studies toward Diepoxin σ (1997) (24)
- Towards Raman optical activity calculations of large molecules. (2005) (24)
- On the role of chiral catalysts in the alkenyl zirconocene/zinc addition to aldehydes: a study of ligand loading and asymmetric amplification. (2003) (24)
- Improved Total-Body Irradiation Survival by Delivery of Two Radiation Mitigators that Target Distinct Cell Death Pathways (2017) (24)
- Total Synthesis and Structural Studies of the Antiviral Marine Natural Product Hennoxazole A (1996) (24)
- Optimization of pyrazole-containing 1,2,4-triazolo-[3,4-b]thiadiazines, a new class of STAT3 pathway inhibitors. (2016) (24)
- Iterative Structure-Based Peptide-Like Inhibitor Design against the Botulinum Neurotoxin Serotype A (2010) (24)
- Sulfonylated aminothiazoles as new small molecule inhibitors of protein phosphatases. (2001) (24)
- Lipidomics Characterization of Biosynthetic and Remodeling Pathways of Cardiolipins in Genetically and Nutritionally Manipulated Yeast Cells. (2017) (23)
- Synthesis and Reactivity of Dioxycarbenium Ions from Epoxy Esters and Cationic Zirconium Complexes (1993) (23)
- Synthetic and model computational studies of molar rotation additivity for interacting chiral centers: a reinvestigation of van't Hoff's principle. (1997) (23)
- Combined chemical–genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma (2016) (23)
- N-Acetyl-l-Cysteine Protects Astrocytes against Proteotoxicity without Recourse to Glutathione (2017) (23)
- Natural product chemistry and anticancer drug discovery (2014) (23)
- In vitro cytotoxicity, pharmacokinetics, tissue distribution, and metabolism of small-molecule protein kinase D inhibitors, kb-NB142-70 and kb-NB165-09, in mice bearing human cancer xenografts (2013) (23)
- Synthesis of (-)-LL-C10037α and Related Manumycin-Type Epoxyquinols (1995) (23)
- Strategies for Discovery of Small Molecule Radiation Protectors and Radiation Mitigators (2011) (22)
- Systematic assignment of the configuration of flexible natural products by spectroscopic and computational methods: the bistramide C analysis. (2005) (22)
- HPLC determinations of enantiomeric ratios. (2007) (22)
- Total Synthesis and Biological Evaluation of Tubulysin Analogues. (2016) (22)
- GS-Nitroxide (JP4-039)-Mediated Radioprotection of Human Fanconi Anemia Cell Lines (2011) (22)
- Anti-Ferroptosis Drug Enhances Total-Body Irradiation Mitigation by Drugs that Block Apoptosis and Necroptosis (2020) (22)
- Phosphatases as targets for cancer treatment. (2009) (22)
- Mitochondrial targeting of radioprotectants using peptidyl conjugates. (2007) (22)
- Synthetic applications of organozirconocenes (1997) (22)
- Mitochondrial targeted β-lapachone induces mitochondrial dysfunction and catastrophic vacuolization in cancer cells. (2015) (21)
- Amelioration of Radiation-Induced Oral Cavity Mucositis and Distant Bone Marrow Suppression in Fanconi Anemia Fancd2–/– (FVB/N) Mice by Intraoral GS-Nitroxide JP4-039 (2014) (21)
- Glycosylation via Cp2ZrCl2/AgClO4-mediated activation of anomeric sulfoxides. (2001) (21)
- Synthesis of a library of tricyclic azepinoisoindolinones (2012) (21)
- Studies toward the synthesis of Stemona alkaloids; a short synthesis of the tricyclic core of tuberostemonines (1996) (21)
- Water‐Accelerated Claisen Rearrangements (2002) (21)
- Synthesis and biological evaluation of a selective N- and p/q-type calcium channel agonist. (2012) (21)
- Synthesis of (+/-)-thiohalenaquinone by iterative metalations of thiophene. (2007) (21)
- Discovery of Diverse Small Molecule Chemotypes with Cell-Based PKD1 Inhibitory Activity (2011) (21)
- Imine additions of internal alkynes for the synthesis of trisubstituted (E)-alkene and cyclopropane peptide isosteres (2005) (21)
- Dual G1 and G2/M phase inhibition by SC-ααδ9, a combinatorially derived Cdc25 phosphatase inhibitor (1999) (21)
- Silver(I)-Catalyzed Addition of Zirconocenes to Epoxy Esters: A New Entry to 1,4-Dicarbonyl Compounds and Pyridazinones (1999) (20)
- Chapter Three – Synthesis and Structure-Activity Studies of Lissoclinum Peptide Alkaloids (1998) (20)
- Lipophilicity screening of novel drug-like compounds and comparison to clog P. (2012) (20)
- Metathesis reactions of pyrazolotriazinones generate dynamic combinatorial libraries. (2005) (20)
- Assignment of the absolute configuration of [n]-ladderanes by TD-DFT optical rotation calculations. (2005) (20)
- Application of Divergent Multi-Component Reactions in the Synthesis of a Library of Peptidomimetics Based on γ-amino-α,β-Cyclopropyl Acids (2005) (20)
- A screen for modulators of large T antigen's ATPase activity uncovers novel inhibitors of Simian Virus 40 and BK virus replication. (2012) (20)
- The cytotoxic effects of regorafenib in combination with protein kinase D inhibition in human colorectal cancer cells (2014) (20)
- Small molecule GS-nitroxide ameliorates ionizing irradiation-induced delay in bone wound healing in a novel murine model. (2010) (20)
- Biological evaluation of newly synthesized quinoline-5,8-quinones as Cdc25B inhibitors. (2006) (20)
- Microwave-assisted synthesis of allylic amines: considerable rate acceleration in the hydrozirconation-transmetalation-aldimine addition sequence. (2004) (19)
- Synthesis of bicyclic ortho esters by epoxy ester rearrangements and study of their ring-opening reactions. (2001) (19)
- Cellular Analysis of Disorazole C1 and Structure–Activity Relationship of Analogs of the Natural Product (2006) (19)
- 3-Amino-2H-azirines in the synthesis of peptides: : Tetrapeptides with α,α-disubstituted α-amino acids (1989) (19)
- Separation of Cdc25 dual specificity phosphatase inhibition and DNA cleaving activities in a focused library of analogs of the antitumor antibiotic Dnacin (2002) (19)
- Structure-activity relationships of 4-position diamine quinoline methanols as intermittent preventative treatment (IPT) against Plasmodium falciparum. (2011) (19)
- Regulation and targeting of androgen receptor nuclear localization in castration-resistant prostate cancer. (2020) (19)
- Synthesis of highly oxygenated dinaphthyl ethers via SNAr reactions promoted by Barton's base. (2003) (19)
- Synthesis of the Antitumor Antibiotic LL-C10037.alpha. (1994) (19)
- Dihydropyrimidinones and -thiones with improved activity against human polyomavirus family members. (2016) (19)
- Use of transcriptional synergy to augment sensitivity of a splicing reporter assay. (2006) (19)
- Exploring the structure-activity relationships of ABCC2 modulators using a screening approach. (2015) (19)
- 2-TRIMETHYLSILYLETHANESULFONYL CHLORIDE (SES-CI) : (ETHANESULFONYL CHLORIDE, 2-(TRIMETHYLSILYL)-) (1998) (18)
- Synthesis and biological activity of prodrug inhibitors of the thioredoxin-thioredoxin reductase system. (2005) (18)
- Heat shock protein responses to aging and proteotoxicity in the olfactory bulb (2015) (18)
- Screening of antimicrobial agents for in vitro radiation protection and mitigation capacity, including those used in supportive care regimens for bone marrow transplant recipients. (2010) (18)
- Hsp70 Binds to the Androgen Receptor N-terminal Domain and Modulates the Receptor Function in Prostate Cancer Cells (2018) (18)
- A Targeted Library Screen Reveals a New Inhibitor Scaffold for Protein Kinase D (2012) (18)
- Synthesis and Ag(I) complexation studies of tethered westiellamide. (2006) (18)
- Synthesis and hetero-Michael addition reactions of 2-alkynyl oxazoles and oxazolines. (2005) (18)
- GS-nitroxide (JP4-039)-mediated radioprotection of human Fanconi anemia cell lines. (2011) (17)
- Formal Alder-ene reaction of a bicyclo[1.1.0]butane in the synthesis of the tricyclic quaternary ammonium core of daphniglaucins. (2008) (17)
- The GS-nitroxide JP4-039 improves intestinal barrier and stem cell recovery in irradiated mice (2018) (17)
- Effectiveness of Analogs of the GS-Nitroxide, JP4-039, as Total Body Irradiation Mitigators. (2017) (17)
- An approach toward the total synthesis of cyclotheonamides; preparation of a C(1) to N(14) segment (1992) (17)
- Toward the total synthesis of lophotoxin - New methodologies and synthetic strategies (2006) (17)
- Complete reversal of Lambert–Eaton myasthenic syndrome synaptic impairment by the combined use of a K+ channel blocker and a Ca2+ channel agonist (2014) (17)
- The combination of thioxodihydroquinazolinones and platinum drugs reverses platinum resistance in tumor cells by inducing mitochondrial apoptosis independent of Bax and Bak. (2015) (17)
- Synthesis of hydroxylated bicyclic amino acids from L-tyrosine: octahydro-1H-indole carboxylates. (2008) (17)
- Amelioration of Radiation-Induced Pulmonary Fibrosis by a Water-Soluble Bifunctional Sulfoxide Radiation Mitigator (MMS350) (2013) (17)
- Inhibition of Androgen Receptor Nuclear Localization and Castration-Resistant Prostate Tumor Growth by Pyrroloimidazole-based Small Molecules (2017) (17)
- ETHE1 and MOCS1 deficiencies: Disruption of mitochondrial bioenergetics, dynamics, redox homeostasis and endoplasmic reticulum-mitochondria crosstalk in patient fibroblasts (2019) (17)
- Synthesis and biological evaluation of inhibitors of botulinum neurotoxin metalloprotease (2009) (16)
- A Focused Library of Tetrahydropyrimidinone Amides via a Tandem Biginelli-Ugi Multi-Component Process (2006) (16)
- Pharmacology and antitumor activity of a quinolinedione Cdc25 phosphatase inhibitor DA3003-1 (NSC 663284). (2007) (16)
- Antioxidant Approaches to Management of Ionizing Irradiation Injury (2015) (16)
- Amelioration of Head and Neck Radiation-Induced Mucositis and Distant Marrow Suppression in Fanca–/– and Fancg–/– Mice by Intraoral Administration of GS-Nitroxide (JP4-039) (2018) (16)
- Mitotic slippage in non-cancer cells induced by a microtubule disruptor, disorazole C1 (2010) (16)
- Memory of chirality in rebound cyclizations of α-amide radicals (2013) (16)
- Spiroketals via oxidative rearrangement of enol ethers. (2007) (16)
- Geographic Variability and Anti-Staphylococcal Activity of the Chrysophaentins and Their Synthetic Fragments (2012) (16)
- Radical cleavage of a β-hydroxy azide: a reversal of regioselectivity in the oxidative fragmentation of hydroindoles (2000) (16)
- Total Synthesis of the Spiroketal Naphthoquinone (±)-Diepoxin σ (1999) (16)
- Investigational inhibitors of PTP4A3 phosphatase as antineoplastic agents (2014) (16)
- Post-translational import of protein into the endoplasmic reticulum of a trypanosome: an in vitro system for discovery of anti-trypanosomal chemical entities. (2009) (16)
- Fluorous Synthesis: A Fluorous‐Phase Strategy for Improving Separation Efficiency in Organic Synthesis (1997) (16)
- Hsp70 and the Unfolded Protein Response as a Challenging Drug Target and an Inspiration for Probe Molecule Development. (2020) (16)
- Condensation reactions of guanidines with bis-electrophiles: Formation of highly nitrogenous heterocycles. (2013) (16)
- Influence of base and structure in the reversible covalent conjugate addition of thiol to polycyclic enone scaffolds. (2013) (16)
- Inhibition of Androgen Receptor Function and Level in Castration‐Resistant Prostate Cancer Cells by 2‐[(isoxazol‐4‐ylmethyl)thio]‐1‐(4‐phenylpiperazin‐1‐yl)ethanone (2017) (15)
- Synthesis of Functionalized Isoindolinones: Addition of In Situ Generated Organoalanes to Acyliminium Ions. (2007) (15)
- Determination of the absolute configuration of 1,3,5,7-tetramethyl-1,3-dihydroindol-2-one by optical rotation computation (1999) (15)
- Amelioration of radiation esophagitis by orally administered p53/Mdm2/Mdm4 inhibitor (BEB55) or GS-nitroxide. (2011) (15)
- Optimization of Phenyl Indole Inhibitors of the AAA+ ATPase p97 (2018) (15)
- XJB-5-131-mediated improvement in physiology and behaviour of the R6/2 mouse model of Huntington's disease is age- and sex- dependent (2018) (15)
- ZIRCONOCENE-CATALYZED CATIONIC DIELS-ALDER REACTIONS (1995) (15)
- Synthesis and Evaluation of a Mitochondria-Targeting Poly(ADP-ribose) Polymerase-1 Inhibitor. (2018) (15)
- Small Molecule Antagonists of the Nuclear Androgen Receptor for the Treatment of Castration-Resistant Prostate Cancer (2016) (14)
- Genetic re-engineering of polyunsaturated phospholipid profile of Saccharomyces cerevisiae identifies a novel role for Cld1 in mitigating the effects of cardiolipin peroxidation. (2018) (14)
- Enantioselective synthesis of the AB-ring system of the antitumor antibiotic tetrazomine. (2001) (14)
- Formation of 6-Azaindoles by Intramolecular Diels-Alder Reaction of Oxazoles and Total Synthesis of Marinoquinoline A. (2020) (14)
- Structure-based virtual screening identifies a small-molecule inhibitor of the profilin 1–actin interaction (2017) (14)
- 2-Guanidinoquinazolines as new inhibitors of the STAT3 pathway. (2014) (14)
- Disruption of Insulin-Like Growth Factor-1 Signaling and Down-Regulation of Cdc2 by SC-ααδ9, a Novel Small Molecule Antisignaling Agent Identified in a Targeted Array Library (1998) (14)
- Pharmacologic Profiling of Phosphoinositide 3-Kinase Inhibitors as Mitigators of Ionizing Radiation–Induced Cell Death (2013) (14)
- Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding. (2019) (14)
- Kinetic vs. thermodynamic control in hydrozirconation reactions (1998) (14)
- Synthesis of chemoreversible prodrugs of ARA-C (1991) (14)
- A bifunctional dimethylsulfoxide substitute enhances the aqueous solubility of small organic molecules. (2012) (14)
- Hydrophosphination of Bicyclo[1.1.0]butane-1-carbonitriles. (2016) (14)
- Toll-like receptor 4–mediated enteric glia loss is critical for the development of necrotizing enterocolitis (2021) (13)
- Small molecule regulation of phosphatase-dependent cell signaling pathways. (2003) (13)
- Synthesis of phosphaguanidines by hydrophosphination of carbodiimides with phosphine boranes. (2014) (13)
- Second-generation Probiotics Producing IL-22 Increase Survival of Mice After Total Body Irradiation (2019) (13)
- Mitochondria are a substrate of cellular memory (2019) (13)
- Allylic Alcohols by Alkene Transfer from Zirconium to Zinc: 1‐[(tert‐Butyldiphenylsilyl)oxy]‐Dec‐3‐en‐5‐ol (2003) (13)
- Click chemistry: Straining to react. (2016) (13)
- Cycloadditions in heterocycle and alkaloid synthesis (2013) (13)
- Organozirconocene-mediated polyene synthesis: Preparation of asukamycin and manumycin a side chains (1997) (13)
- Compensatory increases of select proteostasis networks after Hsp70 inhibition in cancer cells (2018) (13)
- Pharmacophore refinement guides the design of nanomolar-range botulinum neurotoxin serotype a light chain inhibitors (2010) (13)
- Triple hybrids of steroids, spiroketals, and oligopeptides as new biomolecular chimeras. (2009) (13)
- The antisignaling agent SC-alpha alpha delta 9, 4-(benzyl-(2-[(2,5-diphenyloxazole-4-carbonyl)amino]ethyl)carbamoyl)- 2-decanoylaminobutyric acid, is a structurally unique phospholipid analogue with phospholipase C inhibitory activity. (2002) (13)
- A chemical genetics approach identifies PTP4A3 as a regulator of colon cancer cell adhesion (2018) (12)
- Affinity Capture of p97 with Small-Molecule Ligand Bait Reveals a 3.6 Å Double-Hexamer Cryoelectron Microscopy Structure. (2021) (12)
- Microwave-assisted "libraries from libraries" approach toward the synthesis of allyl- and C-cyclopropylalkylamides. (2005) (12)
- A Five-Component Biginelli-Diels-Alder Cascade Reaction (2018) (12)
- Synthesis and ring-chain-ring tautomerism of bisoxazolidines, thiazolidinyloxazolidines, and spirothiazolidines. (2011) (12)
- Methodology for the enantioselective synthesis of aldols and other 1,3-dioxygenated systems (1990) (12)
- Bis-cyclopropane analog of disorazole C1 is a microtubule-destabilizing agent active in abcb1-overexpressing human colon cancer cells (2015) (12)
- Synthesis and Optimization of Kv7 (KCNQ) Potassium Channel Agonists: The Role of Fluorines in Potency and Selectivity. (2019) (12)
- Synergy between microtubule destabilizing agents and neurokinin 1 receptor antagonists identified by an siRNA synthetic lethal screen (2009) (12)
- New calcium channel agonists as potential therapeutics in Lambert–Eaton myasthenic syndrome and other neuromuscular diseases (2012) (12)
- Synthesis and Biological Activity of a Focused Library of Mitogen‐activated Protein Kinase Phosphatase Inhibitors (2007) (11)
- Heat shock protein defenses in the neocortex and allocortex of the telencephalon (2015) (11)
- Cell-active dual specificity phosphatase inhibitors identified by high-content screening. (2005) (11)
- Mechanism of action of selective inhibitors of IL-6 induced STAT3 pathway in head and neck cancer cell lines (2017) (11)
- Esophageal radioprotection by swallowed JP4-039/F15 in thoracic-irradiated mice with transgenic lung tumors. (2014) (11)
- PTPRT epigenetic silencing defines lung cancer with STAT3 activation and can direct STAT3 targeted therapies (2020) (11)
- Lambert–Eaton myasthenic syndrome: mouse passive‐transfer model illuminates disease pathology and facilitates testing therapeutic leads (2018) (11)
- Cascade cyclization triggered by imine formation. Formal synthesis of the alkaloid (±)-stemoamide and its 9a-epimer (2015) (11)
- Synthesis of (–)-(S,S)- bis(4-isopropyloxazoline) (4S, 4S')-2,2'-(Propane-2,2-diyl)bis(4-isopropyl-4,5-dihydrooxazole) (2006) (11)
- Synthesis and chemical diversity analysis of bicyclo[3.3.1]non-3-en-2-ones. (2010) (11)
- A novel androgen receptor antagonist JJ‐450 inhibits enzalutamide‐resistant mutant ARF876L nuclear import and function (2019) (11)
- Stereochemistry of oxachlorocarbene S(N)i reactions. (2005) (11)
- Catalytic asymmetric aziridination of aryl imines (2007) (11)
- Asymmetric Total Synthesis and Biological Evaluation of (+)-Cycloclavine (2018) (11)
- Hydrophosphination of propargylic alcohols and amines with phosphine boranes. (2013) (11)
- Linear and Nonlinear Support Vector Machine for the Classification of Human 5‐HT1A Ligand Functionality (2012) (11)
- Synthetic applications of ortho esters (1999) (11)
- Optical Rotation Computation, Total Synthesis, and Stereochemistry Assignment of the Marine Natural Product Pitiamide A. (2000) (11)
- Evaluation of potential ionizing irradiation protectors and mitigators using clonogenic survival of human umbilical cord blood hematopoietic progenitor cells. (2013) (10)
- Imidazolium compounds are active against all stages of Trypanosoma cruzi. (2014) (10)
- Synthesis of Heterocyclic Triads by Pd-Catalyzed Cross-Couplings and Evaluation of Their Cell-Specific Toxicity Profile (2014) (10)
- Can Radiosensitivity Associated with Defects in DNA Repair be Overcome by Mitochondrial-Targeted Antioxidant Radioprotectors (2014) (10)
- Synthesis and Evaluation of Anthelmintic and Cytotoxic Properties of Bis- 1,3-Azole Analogs of Natural Products (2006) (10)
- Use of deoxo-fluor for double cyclization to bis-thiazolines. Limitations of this agent for the synthesis of oxazolines (2004) (10)
- Methyl‐ and (Trifluoromethyl)alkene Peptide Isosteres: Synthesis and Evaluation of Their Potential as β‐Turn Promoters and Peptide Mimetics. (1999) (10)
- Endothelial Iron Homeostasis Regulates Blood-Brain Barrier Integrity via the HIF2α—Ve-Cadherin Pathway (2021) (10)
- Effects of thoracic irradiation on pulmonary endothelial compared to alveolar type-II cells in fibrosis-prone C57BL/6NTac mice. (2013) (10)
- New antiestrogens from a library screen of homoallylic amides, allylic amides, and C-cyclopropylalkylamides. (2005) (10)
- Synthesis of pyrrolo[1,3]diazepines by a dipolar cycloaddition - retro-Mannich domino reaction. (2009) (10)
- Chapter 11 – Conformational Restriction and Steric Hindrance in Medicinal Chemistry (2015) (10)
- Regioselective Palladium-Catalyzed Cross-Coupling Reactions of 2,4,7-Trichloroquinazoline. (2010) (10)
- Binding Site Interactions of Modulators of Breast Cancer Resistance Protein, Multidrug Resistance-Associated Protein 2, and P-Glycoprotein Activity (2020) (10)
- Total synthesis of N 14 -desacetoxytubulysin H (2007) (10)
- Chemical modulation of Kv7 potassium channels. (2021) (9)
- Targeting p75 neurotrophin receptors ameliorates spinal cord injury‐induced detrusor sphincter dyssynergia in mice (2018) (9)
- Tapping the therapeutic potential of protein tyrosine phosphatase 4A with small molecule inhibitors. (2019) (9)
- Chiral ligand optimization in the asymmetric zirconium-zinc transmetalation aldehyde addition reaction. (2008) (9)
- Synthesis and Evaluation of Anthelmintic and Cytotoxic Properties of [2,5]Bis-1,3-Azole Analogs of Bengazoles (2009) (9)
- A case study from the chemistry core of the Pittsburgh Molecular Library Screening Center: the Polo-like kinase polo-box domain (Plk1-PBD). (2009) (9)
- Chiral action at a distance: remote substituent effects on the optical activity of calyculins A and B. (2000) (9)
- Continuous One Year Oral Administration of the Radiation Mitigator, MMS350, after Total-Body Irradiation, Restores Bone Marrow Stromal Cell Proliferative Capacity and Reduces Senescence in Fanconi Anemia (Fanca-/-) Mice (2018) (9)
- Recent advances in the chemistry of zirconocenes (2004) (9)
- New Cav2 calcium channel gating modifiers with agonist activity and therapeutic potential to treat neuromuscular disease (2018) (9)
- Homoallylic amines by reductive inter- and intramolecular coupling of allenes and nitriles (2011) (9)
- Indole synthesis by palladium-catalyzed tandem allylic isomerization - furan Diels-Alder reaction. (2017) (9)
- Next-Generation Cell-Active Inhibitors of the Undrugged Oncogenic PTP4A3 Phosphatase (2019) (9)
- In-flow photooxygenation of aminothienopyridinones generates iminopyridinedione PTP4A3 phosphatase inhibitors. (2019) (9)
- Direct involvement of Hsp70 ATP hydrolysis in Ubr1-dependent quality control (2020) (9)
- A Novel Small Molecule Targets Androgen Receptor and Its Splice Variants in Castration-Resistant Prostate Cancer (2019) (8)
- Structural Basis of Polyketide Synthase O-Methylation. (2018) (8)
- A structure‐activity relationship study of ABCC2 inhibitors (2017) (8)
- Addition of organochromium reagents to aldehydes, ketones and enones: a low-temperature version of the Nozaki–Hiyama reaction (1993) (8)
- Exploring the optical activity tensor by anisotropic Rayleigh optical activity scattering. (2008) (8)
- A screening method for chiral selectors that does not require covalent attachment. (2006) (8)
- Ring‐Strain‐Enabled Reaction Discovery: New Heterocycles from Bicyclo[1.1.0]butanes (2015) (8)
- Synthesis and Biological Evaluation of Deoxypreussomerin A and Palmarumycin CP1 and Related Naphthoquinone Spiroketals. (2001) (8)
- A High-Content Screen Reveals New Small-Molecule Enhancers of Ras/Mapk Signaling as Probes for Zebrafish Heart Development (2018) (8)
- Delivery of a mitochondria‐targeted antioxidant from biocompatible, polymeric nanofibrous scaffolds (2020) (7)
- Semipinacol-Type Rearrangements of [3-(Arylsulfonyl)bicyclo[1.1.0]butan-1-yl]alkanols. (2021) (7)
- Solubilized zirconocene dihydride as a promotor of alkene coupling reactions (2000) (7)
- Grob-Type Fragmentation Releases Paracyclophane Ring Strain in a Late-Stage Precursor of Haouamine A. (2019) (7)
- Induction of Cdc25B expression by epidermal growth factor and transforming growth factor-alpha. (2004) (7)
- Synthesis of 1,2,4-triazines and the triazinoisoquinolinedione DEF ring system of noelaquinone. (2012) (7)
- Identifying a Resistance Determinant for the Antimitotic Natural Products Disorazole C1 and A1 (2010) (7)
- Allosteric Modulation of Phosphatase Activity May Redefine Therapeutic Value. (2016) (7)
- Stereochemical Control in the Ester Enolate Claisen Rearrangement. Part 1. Stereoselectivity in Silyl Ketene Acetal Formation. (1991) (7)
- Improved hematopoiesis in GS-nitroxide (JP4-039)-treated mouse long-term bone marrow cultures and radioresistance of derived bone marrow stromal cell lines. (2014) (7)
- New Inhibitors of the Thioredoxin—Thioredoxin Reductase System Based on a Naphthoquinone Spiroketal Natural Product Lead. (2010) (7)
- The impact of ionizing radiation on placental trophoblasts. (2014) (7)
- Synthesis and structure–activity relationships of small molecule inhibitors of the simian virus 40 T antigen oncoprotein, an anti-polyomaviral target. (2014) (7)
- New opportunities for pregnane X receptor (PXR) targeting in drug development. lessons from Enantio- and species-specific PXR ligands identified from a discovery library of amino acid analogues. (2007) (7)
- Endo entry to the nortricyclyl-norbornenyl cation system: stereochemistry in the fragmentation of endo-5-norbornenyl-2-oxychlorocarbene. (2005) (7)
- Induction of TGF-β by Irradiation or Chemotherapy in Fanconi Anemia (FA) Mouse Bone Marrow Is Modulated by Small Molecule Radiation Mitigators JP4-039 and MMS350. (2017) (7)
- Investigation of ligand loading and asymmetric amplification in CHAOx-catalyzed asymmetric diethylzinc additions (2003) (6)
- Discovery and Characterization of a Biologically Active Non–ATP-Competitive p38 MAP Kinase Inhibitor (2016) (6)
- Biosynthesis, total synthesis, and biological profiles of Ergot alkaloids. (2021) (6)
- Oxidative Spiroacetalizations and Spirolactonizations of Arenes (2004) (6)
- Studies toward a library of tetrahydrofurans: click and MCR products of mono- and bis-tetrahydrofurans. (2010) (6)
- A threonine turnstile defines a dynamic amphiphilic binding motif in the AAA ATPase p97 allosteric binding site. (2017) (6)
- An ESR analysis of the mechanism of pericyclic reactions of bicyclobutane. (2009) (6)
- Reagents for high-throughput solid-phase and solution-phase organic synthesis (2005) (6)
- π-Allyl palladium approach toward the diazabicyclo[3.2.1]octane core of the naphthyridinomycin alkaloids (2006) (6)
- Hydrozirconation and Its Applications (2005) (6)
- Bildung tricyclischer Thietan-Derivate durch intramolekulare(2+2)-Cycloaddition (1987) (6)
- 2,2,6,6-Tetramethylpiperidin-1-yloxycarbonyl: A Protecting Group for Primary, Secondary, and Heterocyclic Amines. (2018) (6)
- Synthese von 4-arylthio-3-oxazolin-5-onen (1984) (6)
- From natural products to biological tools (2007) (6)
- Liquid chromatography-tandem mass spectrometric assay for the quantitation of the novel radiation protective agent and radiation mitigator JP4-039 in murine plasma. (2018) (6)
- Dual G1 and G2/M phase inhibition by SC-alpha alpha delta 9, a combinatorially derived Cdc25 phosphatase inhibitor. (1999) (6)
- [2,3]-Sigmatropic rearrangements of 2-phosphineborane 2-propen-1-ols: rapid access to enantioenriched diphosphine monoxide derivatives. (2013) (6)
- Effects of Ferroptosis on the Metabolome in Cardiac Cells: The Role of Glutaminolysis (2022) (6)
- Transmetalation Reactions Producing Organocopper Compounds (2011) (5)
- Synthesis and Biological Evaluation of Inhibitors of Botulinum Neurotoxin Metalloprotease. (2009) (5)
- Unique integrated stress response sensors regulate cancer cell susceptibility when Hsp70 activity is compromised (2021) (5)
- Pharmacophore Refinement Guides the Rational Design of Nanomolar-Range Inhibitors of the Botulinum Neurotoxin Serotype A Metalloprotease. (2010) (5)
- Effects of the bifunctional sulfoxide MMS350, a radiation mitigator, on hematopoiesis in long-term bone marrow cultures and on radioresistance of marrow stromal cell lines. (2014) (5)
- A New Synthesis of Gefitinib (2018) (5)
- The Effect of Structure and Mechanism of the Hsp70 Chaperone on the Ability to Identify Chemical Modulators and Therapeutics (2015) (5)
- Perfluorooctane Sulfonate (PFOS) Produces Dopaminergic Neuropathology in Caenorhabditis elegans (2019) (5)
- Combination of a thioxodihydroquinazolinone with cisplatin eliminates ovarian cancer stem cell-like cells (CSC-LCs) and shows preclinical potential (2017) (5)
- Synthesis and biological evaluation of a targeted library of protein phosphatase inhibitors. (2000) (5)
- Evaluation of Different Formulations and Routes for the Delivery of the Ionizing Radiation Mitigator GS-Nitroxide (JP4-039) (2018) (5)
- Tubulin‐Perturbing Naphthoquinone Spiroketals (2008) (5)
- The Mitochondrial Targeted GS-Nitroxide JP4-039 is Radioprotective In Vitro and In Vivo (2008) (5)
- From Aziridines to Oxazolines and Thiazolines: The Heterocyclic Route to Thiangazole (1997) (5)
- Transition‐Metal‐Mediated Cascade Reactions: C,C‐Dicyclopropylmethylamines by Way of Double C,C‐σ‐Bond Insertion into Bicyclobutanes. (2004) (5)
- Total Synthesis of Westiellamide. (1993) (5)
- Improved correction of F508del-CFTR biogenesis with a folding facilitator and an inhibitor of protein ubiquitination. (2021) (5)
- Reevaluation of the Palladium/Carbon-Catalyzed Decarbonylation of Aliphatic Aldehydes (2018) (5)
- Studies on the Synthesis of Stemona Alkaloids. Stereoselective Preparation of the Hydroindole Ring System by Oxidative Cyclization of Tyrosine. (1993) (5)
- CHAPTER 5 – Natural product chemistry and anticancer drug discovery (2008) (4)
- One‐Pot Two‐Step Synthesis of Isochromene‐Fused CF 3 ‐Substituted Pyrazoles (2020) (4)
- One-Pot Synthesis of β-Hydroxy-1,3-Dienes Via Allyltriphenylphosphonium Isomerization Under Mild Conditions(SUPPLEMENTARY MATERIAL) (2006) (4)
- Faculty Opinions recommendation of E and Z alpha-C-galactosylceramides by Julia-Lythgoe-Kocienski chemistry: a test of the receptor-binding model for glycolipid immunostimulants. (2006) (4)
- Diversity-Oriented Synthesis of a Library of Substituted Tetrahydropyrones Using Oxidative Carbon-Hydrogen Bond Activation and Click Chemistry (2011) (4)
- A New Synthesis of 4,5,6,7-Tetrahydropyrazolo[1,5-c]pyrimidines by a Retro-Mannich Cascade Rearrangement (2014) (4)
- The fragmentation of exo-5-norbornenyl-2-oxychlorocarbene: stereochemistry and mechanism (2005) (4)
- Enantioselective Synthesis and Photoracemization Studies of (+)-2-Cyclopropyl-7,8-dimethoxy-2H-chromene-5-carboxylic Acid Methyl Ester, an Advanced Intermediate of a Dihydrofolate Reductase Inhibitor. (1999) (4)
- Three-Component Synthesis of α,β-Cyclopropyl-γ-amino Acids. (2005) (4)
- Biphenyl C-cyclopropylalkylamides: New scaffolds for targeting estrogen receptor beta. (2009) (4)
- The mitochondrial‐targeted reactive species scavenger JP4‐039 prevents sulfite‐induced alterations in antioxidant defenses, energy transfer, and cell death signaling in striatum of rats (2020) (4)
- Structure of the Complex of an Iminopyridinedione Protein Tyrosine Phosphatase 4A3 Phosphatase Inhibitor with Human Serum Albumin (2020) (4)
- Specific RITA Modification Produces Hyperselective Cytotoxicity While Maintaining In Vivo Antitumor Efficacy (2019) (4)
- Arsenic Stimulates Myoblast Mitochondrial EGFR to Impair Myogenesis. (2020) (3)
- Asymmetric Total Synthesis of the Stemona Alkaloid (‐)‐Stenine. (1996) (3)
- Intramolecular Diels–Alder Reactions of Oxazoles, Imidazoles, and Thiazoles (2020) (3)
- A Short Synthesis of Ergot Alkaloids and Evaluation of the 5-HT1/2 Receptor Selectivity of Lysergols and Isolysergols. (2022) (3)
- Novel protein kinase D inhibitors cause potent arrest in cancer cell growth and motility (2010) (3)
- Optical Activity: From Structure-Function to Structure Prediction (2002) (3)
- Formal total synthesis of (+)-diepoxin sigma. (2000) (3)
- Fanconi Anemia Mouse Genotype-specific Mitigation of Total Body Irradiation by GS-Nitroxide JP4-039 (2019) (3)
- 2‐Trimethylsilylethanesulfonyl Chloride (SES‐Cl) (2003) (3)
- Conformational Analysis of Tripeptide Models: Influence of α,α-Disubstituted α-Amino Acids on the Secondary Structure. Part 2. X-Ray Analysis and Conformational Energy Calculations (1988) (3)
- Amelioration of Mucositis in Proton Therapy of Fanconi Anemia Fanca−/− Mice by JP4-039 (2019) (3)
- Oxidative Spiroacetalizations and Spirolactonizations of Arenes. (2005) (3)
- Credentialing and Pharmacologically Targeting PTP4A3 Phosphatase as a Molecular Target for Ovarian Cancer (2021) (3)
- Carbamoyl Anion Addition to Azirines. (2021) (3)
- Topical Application of GS-Nitroxide JP4-039 Emulsion Mitigates Ionizing Irradiation Induced Skin Burns (2010) (3)
- Synthesis and Applications of a Highly Fluorous Alkoxy Ethyl Ether Protective Group. (1999) (3)
- Synthesis of Heterocyclic Triads by Pd‐Catalyzed Cross‐Couplings and Evaluation of Their Cell‐Specific Toxicity Profile. (2014) (3)
- 3D-printed cartridge system for in-flow photo-oxygenation of 7-aminothienopyridinones (2020) (3)
- Synthetic Aspects of Combinatorial Chemistry (2003) (3)
- Synthesis and Selective Functionalization of Thiadiazine 1,1-Dioxides with Efficacy in a Model of Huntington's Disease. (2020) (3)
- Amelioration of Amyotrophic Lateral Sclerosis in SOD1G93A Mice by M2 Microglia from Transplanted Marrow (2019) (3)
- NAD ( P ) H : Quinone Oxidoreductase-1-Dependent and-Independent Cytotoxicity of Potent Quinone Cdc 25 Phosphatase Inhibitors (2004) (3)
- Insights image for “The human milk oligosaccharides 2’-fucosyllactose and 6’-sialyllactose protect against the development of necrotizing enterocolitis by inhibiting toll-like receptor 4 signaling.” (2020) (3)
- In Vivo Antitumor Activity and Induction of Insulin-Like Growth Factor-1-Resistant Apoptosis by SC-ααδ9 (2000) (3)
- Disruption of insulin-like growth factor-1 signaling and down-regulation of cdc2 by SC-alphaalphadelta9, a novel small molecule antisignaling agent identified in a targeted array library. (1998) (3)
- Transmetalation Reactions of Alkylzirconocenes: Copper‐Catalyzed Conjugate Addition to Enones. (2010) (2)
- Restoring mitochondrial cardiolipin homeostasis reduces cell death and promotes recovery after spinal cord injury (2022) (2)
- Preparation of Allylic Alcohols by Alkene Transfer from Zirconium to Zinc. (1994) (2)
- Microwave‐Assisted “Libraries from Libraries” Approach Toward the Synthesis of Allyl‐ and C‐Cyclopropylalkylamides. (2005) (2)
- Transmetalation Reactions of Organosamarium Reagents. Chlorosilane‐ Accelerated Copper‐Catalyzed Conjugate Additions. (1993) (2)
- Redox regulation of Cdc25B by novel cell active quinolinediones (2005) (2)
- Total Synthesis of the Spiroketal Naphthoquinone (.+-.)-Diepoxin σ. (1999) (2)
- (E)-alkene Peptide bond isosteres by cuprate opening of vinyl aziridines. (1999) (2)
- Heat Shock Protein 70 as a Sex-Skewed Regulator of α-Synucleinopathy (2021) (2)
- Total synthesis of (-)-CP 2 -disorazole C 1 (2011) (2)
- The Azirine/Oxazolone Method in Peptide Chemistry: Synthesis of Tripeptide Models. (1988) (2)
- Synthesis of Peptide Thiazolines from β‐Hydroxythioamides. An Investigation of Racemization in Cyclodehydration Protocols. (1994) (2)
- Formal Total Synthesis of (+)-Diepoxin σ. (2001) (2)
- Domino Reactions in Library Synthesis (2013) (2)
- Combination Mitigators, GS-Nitroxide JP4-039 and water Soluble Oxetanyl Sulfoxide MMS350 Improve Survival of Lethally Irradiated Mice (2014) (2)
- How mono- and diphosphine ligands alter regioselectivity of the Rh-catalyzed annulative cleavage of bicyclo[1.1.0]butanes (2022) (2)
- Transient Delivery of a KCNQ2/3-Specific Channel Activator 1 Week After Noise Trauma Mitigates Noise-Induced Tinnitus (2021) (2)
- Abstract 3340: Intraoral administration of mitochondrial targeted GS-nitroxide (JP4-039) radioprotects the oral mucosa but not orthotopic tumors in Fancd2-/- mice (2015) (2)
- Copper‐Catalyzed Conjugate Additions of Organozirconocenes. Synthetic and Mechanistic Studies. (1994) (2)
- Microwave‐Promoted Oxazole Synthesis: Cyclocondensation Cascade of Oximes and Acyl Chlorides. (2005) (2)
- Co(II)-salen catalyzed stereoselective cyclopropanation of fluorinated styrenes. (2019) (2)
- SN2′-Reactions of Peptide Aziridines. A Cuprate-Based Approach to (E)- Alkene Isosteres. (1995) (2)
- Combined injury: irradiation with skin or bone wounds in rodent models (2021) (2)
- Total Synthesis of (.+‐.)‐Nisamycin. (1999) (2)
- Total Synthesis of Palmarumycin CP1 and (.+-.)-Deoxypreussomerin A. (1998) (2)
- Oxetanyl Sulfoxide MMS-350 Ameliorates Pulmonary Fibrosis In Vitro, In Vivo, and Ex Vivo. (2020) (2)
- (+)-JJ-74-138 is a novel non-competitive androgen receptor antagonist. (2022) (1)
- Total synthesis and structure assignment of aranorosin (1993) (1)
- An Investigation of the Mitsunobu Reaction in the Preparation of Peptide Oxazolines, Thiazolines, and Aziridines. (2010) (1)
- Medicinal Chemistry: From Targets to Therapies. (2019) (1)
- Total Synthesis of N14-Desacetoxytubulysin H (I). (2007) (1)
- Total Synthesis of (-)-Thiangazole and Structurally Related Polyazoles. (1996) (1)
- Small Molecule GS-nitroxide Ameliorates the Ionizing Irradiation-induced Delay in Bone Wound Healing Measured in a Novel Murine Model (2009) (1)
- Toward the Total Synthesis of Iophotoxin — New Methodologies and Synthetic Strategies. (2007) (1)
- Conformational Analysis of Tripeptide Models: Influence of α,α‐Disubstituted α‐Amino Acids on the Secondary Structure. Part 1. NMR and CD Investigations. (1988) (1)
- Effective Topical Delivery of Radiomitigator GS-Nitroxide (JP4-039) by Microneedle Arrays (2015) (1)
- Radical Cyclizations of Alkenyl-Substituted 4,5-Dihydro-1,3-thiazole-5-thiols. (1989) (1)
- Isolation, Biology and Chemisty of the Disorazoles: New Anticancer Macrodiolides (2009) (1)
- Total Synthesis and Stereochemical Revision of (+)‐Aeruginosin 298‐A. (2001) (1)
- Potentiation of neuromuscular transmission by a small molecule calcium channel gating modifier improves motor function in a severe spinal muscular atrophy mouse model. (2023) (1)
- Development of an Automated Screen for Kv7.2 Potassium Channels and Discovery of a New Agonist Chemotype. (2022) (1)
- Three‐Component Aldimine Addition—Cyclopropanation. An Efficient New Methodology for Amino Cyclopropane Synthesis. (2001) (1)
- Recent syntheses and biological profiling of quassinoids. (2022) (1)
- Contributions of Academic Labs to the Discovery and Development of Chemical Biology Tools (2013) (1)
- Silver(I)-catalyzed addition of zirconocenes to glycal epoxides. A new synthesis of alpha-C-glycosides. (2005) (1)
- Diels—Alder Approaches to Ring-Functionalized Cyclic β-Amino Acids. (2001) (1)
- Enantioselective synthesis and selective functionalization of 4-aminotetrahydroquinolines as novel GLP-1 secretagogues. (2021) (1)
- Small Molecule GS-Nitroxide Radiation Mitigator JP4-039/F14 Is Safe and Effective in Pregnant E13.5 Mice (2016) (1)
- Rapid Carboalumination of Alkynes in the Presence of Water. (1993) (1)
- Comprar The Chemistry of Heterocyclic Compounds, Volume 63, The Naphthyridines | Desmond J. Brown | 9780471751595 | Wiley (2007) (1)
- A PXR Agonist with Unique Species-Dependent Stereoselectivity and Its Implications in Drug Development (2005) (1)
- Thiolysis of Oxazolines: A New, Selective Method for the Direct Conversion of Peptide Oxazolines into Thiazolines. (1996) (1)
- Synthesis of (.+‐.)‐Thiohalenaquinone by Iterative Metalations of Thiophene. (2007) (1)
- Water-Accelerated Tandem Claisen Rearrangement—Catalytic Asymmetric Carboalumination. (2001) (1)
- Independent Mechanistic Inhibition of Cdc 25 Phosphatases by a Natural Product (2006) (1)
- Endothelial iron homeostasis regulates BBB integrity via the HIF2α – Ve-cadherin pathway (2020) (1)
- Organozirconocenes in Organic Synthesis: Tandem Epoxide Rearrangement ‐ Carbonyl Addition. (2010) (1)
- Pharmacokinetic and pharmacodynamic studies of a novel antitumor wortmannin analogue inhibitor of phosphatidylinositol-3-kinase (2004) (1)
- Synthesis of the C1′ —C11′ Segment of Leucascandrolide A. (2001) (1)
- Synthesis of Peptides Containing α,α‐Disubstituted α‐Amino Acids by the Azirine/Oxazolone Method. The (12‐20)‐Nonapeptide of the Ionophore Alamethicin. (1990) (1)
- Synthesis and Applications of a Fluorous THP Protective Group. (1999) (1)
- Book Review: Transition Metal Reagents and Catalysts. Innovations in Organic Synthesis. By Jiro Tsuji (2001) (1)
- 3-Amino-2H-azirines in the Synthesis of Peptides: Tetrapeptides with α,α-Disubstituted α-Amino Acids. (1989) (1)
- Diversity-Oriented Synthesis of Peptidomimetics: How and Why (2012) (1)
- Screening for in vitro radiation protection and mitigation capacity of antimicrobial agents including those used in supportive care regimens for bone marrow transplant recipients (2015) (1)
- Potentially Lethal Damage Repair is Enhanced by the Mitochondria-targeted Nitroxide JP4-039 (2009) (1)
- Oral Delivery of Mitochondrial Targeted GS-Nitroxide JP4-039 Protects Fanconi Anemia (FA) D2 -/- Mice From Irradiation Mucositis (2012) (1)
- Reduction of Late Pulmonary Fibrosis in Thoracic-Irradiated C57bl/6hnsd Mice by a Water Soluble Radiation Mitigator MMS-350 (2013) (1)
- Zirconocene-Catalyzed Epoxy Ester-ortho Ester Rearrangement: A New Method for the Protection of Polyfunctionalized Carboxylic Acids and the Asymmetric Synthesis of ortho Esters. (2010) (1)
- Synthesis and Evaluation of Bifunctional PTP4A3 Phosphatase Inhibitors Activating the ER Stress Pathway. (2021) (1)
- Synthesis of Oxazines and Thiazines by Cyclodehydration of Hydroxy Amides and Thioamides. (1998) (1)
- Chlorobis(cyclopentadienyl)hydridozirconium (2006) (1)
- Radical Cleavage of a β-Hydroxy Azide: A Reversal of Regioselectivity in the Oxidative Fragmentation of Hydroindoles. (2000) (1)
- Synthesis and Optimization of Nitroxide-Based Inhibitors of Ferroptotic Cell Death in Cancer Cells and Macrophages. (2022) (1)
- Peptide-Bond Formation with C-Terminal α,α-Disubstituted α-Amino Acids via Intermediate Oxazol-5(4H)-ones. (1986) (1)
- Mitigation of Irradiation Induced Potentially Lethal Damage (PLD) in Hematopoietic Cells by Mitochondrial Localized GS-Nitroxide, JP4-039 (2008) (1)
- The Role of Mitochondria in Irradiation-induced Urothelial Dysfunction—implications for Radiation Cystitis (2018) (1)
- A NOVEL HEMIGRAMICIDIN-TEMPO CONJUGATE HAS ANTI-INFLAMMATORY EFFECTS IN VITRO AND IN VIVO.: 30 (2006) (1)
- A Mitochondrially Targeted Nitroxide JP4-039 Protects and Mitigates against Total Body Irradiation Induced Hematopoietic Syndrome (2008) (1)
- ACS Medicinal Chemistry Letters: Technology Notes. (2017) (1)
- Studies Towards the Synthesis of Stemona Alkaloids: A Short Synthesis of the Tricyclic Core of Tuberostemonines. (1996) (1)
- Synthesis of sp3-rich chiral bicyclo[3.3.1]nonanes for chemical space expansion and study of biological activities. (2021) (1)
- Mouse Model for Characterization of Radiation Cystitis and its Prevention Using a New Class of Radioprotectors (2009) (1)
- One‐Pot Hydrozirconation/Copper‐Catalyzed Conjugate Addition of Alkylzirconocenes to Enones (2016) (1)
- Optical Rotation of Noncovalent Aggregates [J. Am. Chem. Soc. 2003, 125, 15696−15697]. (2004) (0)
- Comprar Cumulative Index of Systems Reviewed in the Chemistry of Heterocyclic Compounds | Desmond J. Brown | 9780470275481 | Wiley (2008) (0)
- Synthesis and Evaluation of Potent KCNQ 2 / 3-Specific Channel Activators s (2016) (0)
- Next Generation Potent Cell‐active Inhibitors of the Oncogenic PTP4A3 Phosphatase (2019) (0)
- Stereoselective synthesis of δ-fluorinated isoleucines exploiting consecutive C(sp3)-H bond activations (2022) (0)
- Synthesis of Highly Oxygenated Dinaphthyl Ethers via SNAr Reactions Promoted by Barton′s Base. (2003) (0)
- XJB-5-131 Is a Mild Uncoupler of Oxidative Phosphorylation. (2022) (0)
- 2,4-Bis(4-methylphenylthio)-1,3,2λ5,4λ5-dithiadiphosphetane-2,4-d# ithione: A New Reagent for Thiation of N,N-Disubstituted Amides. (1987) (0)
- Water/MAO Acceleration of the Zirconocene‐Catalyzed Asymmetric Methylalumination of α‐Olefins. (2000) (0)
- Gene Therapy for Mucositis (2015) (0)
- 248 Antitumor activity, pharmacodynamics and toxicity of PX-866 a novel inhibitor of phosphoinositide-3-kinase (2004) (0)
- in Mouse Motor Nerve Terminals Ca I Syndrome Induces Dihydropyridine Sensitivity of Passive Transfer of Lambert-Eaton Myasthenic (2015) (0)
- Structure-activity relationship of ABCC2 inhibitors (2017) (0)
- Removal of Mitochondria-Generated Reactive Oxygen Species Delays Age-Associated Disk Degeneration (2012) (0)
- Synthesis and Hetero‐Michael Addition Reactions of 2‐Alkynyl Oxazoles and Oxazolines. (2005) (0)
- Carbophilic Additions of Organocuprates to 1,3-Thiazole-5(4H)-thiones. (1987) (0)
- TargetHunter: An In Silico Target Identification Tool for Predicting Therapeutic Potential of Small Organic Molecules Based on Chemogenomic Database (2013) (0)
- Wortmannin analog and procedures for their use (2002) (0)
- Total Synthesis and Assignment of Configuration of Lissoclinamide 7 (I) . (1997) (0)
- MP34-16 A NOVEL ANDROGEN RECEPTOR (AR) ANTAGONIST JJ-450 INHIBITS ENZALUTAMIDE-RESISTANT MUTANT AR F876L (2019) (0)
- Tandem Zirconocene Homologation—Aldimine Allylation. (2001) (0)
- Formation of Tricyclic Thietane Derivatives via Intramolecular (2 + 2) Cycloaddition. (1987) (0)
- Stereoselective synthesis of the functionalized spirocyclic core of aranorosin. [Erratum to document cited in CA118(21):212724u] (1993) (0)
- Microwave-Assisted Synthesis of Allylic Amines: Considerable Rate Acceleration in the Hydrozirconation—Transmetalation—Aldimine Addition Sequence. (2004) (0)
- Modern Organocopper Chemistry (2002) (0)
- Abstract 2502: Swallowed small molecule GS-nitroxide, JP-4-039, protects the irradiated esophagus (2011) (0)
- Abstract 202: Depletion of PTP4A3 phosphatase disrupts colorectal cancer cell adhesion and extracellular matrix interactions (2016) (0)
- Intraesophageal Administration of GS-Nitroxide (JP4-039) and p53/MDM2/MDM4 Inhibitor (BEB55) Ameliorates Radiation Esophagitis (2011) (0)
- Abstract 2182: Novel ATP-competitive protein kinase D inhibitors: in vitro characterization and SAR analysis. (2013) (0)
- Carboalumination of 1-Alkynes and in situ Transmetalation to Higher Order Cyanocuprates. Stereospecific Synthesis of Tri- and Disubstituted Olefins by Conjugate Addition to Enones. (1990) (0)
- Synthesis of new scaffolds: bisoxazolidines, thiazolidinyloxazolidines and spirothiazolidines. (2013) (0)
- Faculty Opinions recommendation of Chemoselective hydrogenation of nitro compounds with supported gold catalysts. (2006) (0)
- Amelioration of detrusor-sphincter dyssynergia following spinal cord injury with LM11A-31, a small molecule p75 neurotrophin receptor antagonist (2017) (0)
- Effects of Total Body Irradiation and the Radiation Mitigator MMS350 On Senescence in Fanconi Anemia, Fanca-/-, Mice (2018) (0)
- Mitochondrial ROS Triggers KIN Pathogenesis in FAN1-Deficient Kidneys (2023) (0)
- Abstract 5500: A PTP4A3 inhibitor reduces ovarian cancer dissemination and alters STAT3 and ERK activation (2022) (0)
- Addition of Organochromium Reagents to Aldehydes, Ketones and Enones: A Low‐Temperature Version of the Nozaki‐Hiyama Reaction. (1994) (0)
- p75 neurotrophin receptor inhibition for treatment of radiation cystitis (2016) (0)
- Thermal Generation and Reactions of (Benzylthio)‐ and (Arylthio)‐Substituted Nitrile Ylides. (1988) (0)
- Zirconocene-Catalyzed Cationic Diels-Alder Reactions. (1995) (0)
- Specific Taxa of the Intestinal Microbiome Mitigate the Radiation-Induced Gastrointestinal Syndrome (2020) (0)
- Development of an Automated Screen for Kv7.2 Potassium Channels and Discovery of a New Agonist Chemotype (2022) (0)
- Late Pulmonary Fibrotic Phase Specific Homing of Luciferase+ Bone Marrow Stromal Cells to the Irradiated C57bl/6hnsd Mouse Lung (2013) (0)
- Zirconocene—Zinc Transmetalation and in situ Catalytic Asymmetric Addition to Aldehydes. (1999) (0)
- Proton Radioprotection of Fanconi Anemia (Fanca-/-) Mouse Marrow Stromal Cell Lines by Mitochondrial Targeted GS-Nitroxide JP-4-039 (2018) (0)
- Discovering potent PTP4A3 phosphatase small molecule inhibitors for colorectal cancer (2016) (0)
- Total Synthesis and Structure Assignment of the Antitumor Antibiotic Aranorosin. (1994) (0)
- Asymmetric Total Syntheses of Tuberostemonine (Ia), Didehydrotuberostemonine (II), and 13‐Epituberostemonine (Ib). (2005) (0)
- Abstract #4774: Discovery of a potent and selective small molecule inhibitor of PKD functionality (2009) (0)
- Synthesis of the Antitumor Antibiotic LL-C10037α. (1994) (0)
- CCDC 790921: Experimental Crystal Structure Determination (2011) (0)
- Faculty Opinions recommendation of Total synthesis of tubulysin U and V. (2006) (0)
- Conjugate Addition Reactions of Organosamarium Species via in situ Transmetalation to Cu(I) Salts. (1992) (0)
- Inhibition of p75 neurotrophin receptors reduces neural degeneration and lower urinary tract dysfunction following spinal cord injury (2016) (0)
- ARYLTHIO-SUBSTITUTED NITRILE YLIDES BY THERMOLYSIS OF 4-(ARYLTHIO)-3-OXAZOLIN-5-ONES (1985) (0)
- Intraesophageal administratio (JP4-039) and p53/MDM2/MDM4 Inhibitor (BEB55) ameliorates radiation esophagitisn of GS-Nitroxide (2011) (0)
- Abstract PR009: The functional genomic landscape of recurrent glioblastoma (2021) (0)
- Development of New Small Molecule Bone Marrow Radioprotectors. (2005) (0)
- Analogues de chrysophaentine qui inhibent la proteine ftsz (2012) (0)
- Poster ViewingAmelioration of Radiation Induced Oral Cavity Mucositis and Bone Marrow Suppression in FANCA-/- and FANCG -/- Mice Using JP4-039 in F15 Oral Liposomes (2017) (0)
- Effect of temperature, age and lifespan extending interventions on Caenorhabditis elegans models of amyloid beta pathology (2019) (0)
- ILV/VI-3 FROM NATURAL PRODUCTS TO BIOLOGICAL TOOLS(Molecular Mode of Action on Natural Products and Drugs/Chemical Biology and Related Areas) (2006) (0)
- Probing the role of the potent microtubule disrupting agent disorazole C1 in premature cellular senescence induction (2008) (0)
- Impaired Osseous Wound Healing Following Ionizing Irradiation Is Ameliorated by Mitochondrial Targeted Nitroxide JP4-039. (2009) (0)
- Total Synthesis of the Enantiomer (IX) of the Antiviral Marine Natural Product Hennoxazole A. (1995) (0)
- Disruption of the PI3K axis abrogates ionizing radiation‐induced cell death (2013) (0)
- Recently Discovered Oligosaccharide Inhibits Toll-Like Receptor 4 and Prevents Intestinal Stem Cell Apoptosis in Experimental Necrotizing Enterocolitis (2016) (0)
- Faculty Opinions recommendation of Synthesis and evaluation of 1,2,3-triazole containing analogues of the immunostimulant alpha-GalCer. (2007) (0)
- Total Synthesis, Biosynthesis and Biological Profiles of Clavine Alkaloids (2016) (0)
- Cryo-EM structure of human p97 bound to UPCDC30245 inhibitor (2016) (0)
- Tubulin β Cysteine 303 of Down-regulation and Covalent Binding at Cancer Cells Is Associated with Lactone Withaferin A in Human Breast Growth Arrest by the Antitumor Steroidal Signal Transduction (2014) (0)
- Transmetalation Reactions of Alkenylalanes: Copper‐Catalyzed Conjugate Addition to Enones. (1992) (0)
- Deactivation of STAT3 and ERK and Activation of p38 in Ovarian Cancer Cells Treated with a Small Molecule Inhibitor of PTP4A3 Phosphatase (2022) (0)
- Quassinoid analogs exert potent antitumor activity via reversible protein biosynthesis inhibition in human colorectal cancer. (2023) (0)
- A Murine Combined Injury Model of Total Body Irradiation and Skin Wound (2017) (0)
- Water-Accelerated Organometallic Chemistry: Alkyne Carboalumination—Sulfinimine Addition and Asymmetric Synthesis of Allylic Amines. (2003) (0)
- (E)-Alkene Peptide Bond Isosteres by Cuprate Opening of Vinyl Aziridines (2000) (0)
- NOVEL HEMIGRAMICIDIN-TEMPO CONJUGATES AMELIORATE GUT MUCOSAL BARRIER DYSFUNCTION AND CASPASE-3/7 ACTIVATION IN RATS SUBJECTED TO HEMORRHAGIC SHOCK.: 124-S (2005) (0)
- Special Issue: Flow Chemistry (2014) (0)
- Wortmannin analogs and methods for their use (2002) (0)
- In vivo antitumor activity and induction of insulin-like growth factor-1-resistant apoptosis by SC-alphaalphadelta9. (2000) (0)
- Glycosylation via Cp2ZrCl2/AgClO4‐Mediated Activation of Anomeric Sulfoxides. (2002) (0)
- Abstract 5344: Novel thioxodihydroquinazolinone small molecules for combination with platinum drugs to reverse platinum resistance through inducing mitochondrial apoptosis independent of Bax and Bak (2015) (0)
- Arsenic Stimulates Myoblast Mitochondrial Epidermal Growth Factor Receptor to Impair Myogenesis (2020) (0)
- Serial Imaging of Luciferase Positive Bone Marrow Stromal Cell Migration to Form Radiation Pulmonary Fibrosis (2012) (0)
- Stereoselective Synthesis of the Functionalized Spirocyclic Core of Aranorosin. (1993) (0)
- The Mechanism of Inhibition of the Undrugged Oncogenic Phosphatase PTP4A3 by a Novel Small Molecule JMS‐053 (2019) (0)
- Synthesis of (±)-Cycloclavine and (±)-5-epi-Cycloclavine (2011) (0)
- Cryo-EM structure of human p97 bound to ATPgS (Conformation III) (2016) (0)
- Water-Accelerated Organic Transformation (2001) (0)
- Abstract POSTER-THER-1425: Novel small molecules overcoming platinum drug resistance in ovarian cancer cells (2015) (0)
- Stereospecific Synthesis of Peptide Analogs with allo‐Threonine and D‐ allo‐Threonine Residues. (1993) (0)
- 5-Hydroxyindoles by Intramolecular Alkynol—Furan Diels—Alder Cycloaddition. (2013) (0)
- Microwave-Assisted Diels-Alder Approach to 4-SubstitutedIndoles (2009) (0)
- Editorial Advisory Board Members Progress in Heterocyclic Chemistry 2008-2009 (2009) (0)
- JPET #59477 1 NAD(P)H:quinone oxidoreductase-1 (NQO1)-dependent and –independent cytotoxicity of potent quinone Cdc25 phosphatase inhibitors (2003) (0)
- Targeting neurotrophin and nitric oxide signaling to treat spinal cord injury and associated neurogenic bladder overactivity (2022) (0)
- Book Review, Advances in Metal-Organic Chemistry, Volume 4 (1997) (0)
- Ionizing Irradiation Mitigator GS-Nitroxide (JP4-039) is Deliverable in an I.M. Formulation Suitable for Self-Administration (2018) (0)
- Photoactivated Tungsten Hexacarbonyl Catalyzed Conversion of Alkynols to Glycals. (2004) (0)
- π-Allyl Palladium Approach Toward the Diazabicyclo[3.2.1]octane Core of the Naphthyridinomycin Alkaloids. (2007) (0)
- Solubilized Zirconocene Dihydride as a Promotor of Alkene Coupling Reactions. (2001) (0)
- Author response: Unique integrated stress response sensors regulate cancer cell susceptibility when Hsp70 activity is compromised (2021) (0)
- Improved Survival and Development of E13 Fetal Mice By JP4-039/F14 Treatment of Pregnant Females 24 Hours After Total-Body Irradiation (TBI) (2015) (0)
- Diminished Oxidative Stress Responses in Bone Marrow Stromal Cell Lines Derived From Fanconi Anemia (Fanc-D2−/−) Mice (2012) (0)
- Heat shock protein defenses in the neo- and allocortex of the telencephalon (2015) (0)
- Differential Effects of Hsp70 Inhibition within the Tumor and Microenvironment in Multiple Myeloma. (2006) (0)
- Buchbesprechung: Transition Metal Reagents and Catalysts. Innovations in Organic Synthesis. Von Jiro Tsuji. (2001) (0)
- Intraoral GS-Nitroxide (JP4-039) Reduces Local Mucositis and Distant Marrow Suppression Toxicities In Head and Neck Irradiated Fancd2-/- (FVB/N) Mice (2013) (0)
- SYNTHESIS OF 4-ARYLTHIO-3-OXAZOLIN-5-ONES (1985) (0)
- Abstract 2365: A chemical genetics approach identifies PTP4A3 as a regulator of colon cancer cell adhesion (2018) (0)
- Abstract 2532:In vitrocytotoxicity, and pharmacokinetics, tissue distribution, and metabolism of the protein kinase D inhibitors, kb-NB142-70 and kb-NB184-43, in mice bearing human cancer xenografts (2010) (0)
- Synthesis of 4-(Benzylthio)- and 4-(Arylthio)-1,3-oxazole-5(2H)-ones. (1987) (0)
- Stereochemical Control in the Ester Enolate Claisen Rearrangement. Part 2. Chairlike vs Boatlike Transition-State Selection. (1991) (0)
- Synthesis and Reactivity of Dioxycarbenium Ions from Epoxy Esters and Cationic Zirconium Complexes. (2010) (0)
- General Solution to the Synthesis of N‐2‐Substituted 1,2,3‐Triazoles. (2011) (0)
- “LC-NMR and LC-MS: Analysis of Six-compound Mixtures of Analogs of the Antimitotic Marine Natural Product Curacin A (2001) (0)
- Dimethylzinc-mediated addition of alkenylzirconocenes to alpha-keto and alpha-imino esters. (2003) (0)
- t-BuOOH induces ferroptosis in human and murine cell lines (2017) (0)
- The GS-nitroxide JP4-039 improves intestinal barrier and stem cell recovery in irradiated mice (2018) (0)
- Methodology for the Enantioselective Synthesis of Aldols and Other 1,3-Dioxygenated Systems. (1990) (0)
- Optical Signatures of Molecular Dissymmetry: Combining Theory with Experiments to Address Stereochemical Puzzles (2009) (0)
- Water-Accelerated Claisen Rearrangements. (2010) (0)
- Synthesis and Biological Evaluation of Caulibugulones A—E. (2004) (0)
- Methylketene Bis(trimethylsilyl) Acetal (2001) (0)
- Ti-Catalyzed Synthesis of Indolines (2009) (0)
- Nitric Oxide Production Following Irradiation of Tumor and Murine Hematopoietic Progenitor Cells in Vitro (2008) (0)
- Synthesis of Veliparib Prodrugs and Determination of Drug-Release-Dependent PARP-1 Inhibition (2023) (0)
- Disruption of Ovarian Cancer STAT3 and p38 Signaling with a Small-Molecule Inhibitor of PTP4A3 Phosphatase (2023) (0)
- Synaptic Pathophysiology and Treatment of Lambert-Eaton Myasthenic Syndrome (2014) (0)
- Mechanism of precise intracellular targeting of tail-anchored proteins (2015) (0)
- Primary Neurons Mode to a Small Molecule That Is Active in Serotype A from a Pseudo-peptide Binding Inhibition of Metalloprotease Botulinum Enzyme Catalysis and Regulation: (2014) (0)
- Asymmetric Synthesis of the Bioprotective Agent JP4-039 (2011) (0)
- Transition Metals in the Synthesis of Complex Organic Molecules, 2nd Edition (Hegedus, L. S.) (2000) (0)
- An Improved Protocol for Azole Synthesis with PEG‐Supported Burgess Reagent. (1996) (0)
- Total Synthesis is defined as the chemical synthesis of complex molecules, usually natural products, from relatively simple, commercially available starting materials (2008) (0)
- New Approaches to Indoles and Indole Alkaloids (2013) (0)
- Sixteen Semesters of Chemistry at the University of Zürich: A Retrospective on a Formative Time (2008) (0)
- Evaluation of mitochondrial bioenergetics, dynamics, endoplasmic reticulum-mitochondria crosstalk, and reactive oxygen species in fibroblasts from patients with complex I deficiency (2018) (0)
- Synthesis of Bicyclic Orthoesters by Epoxy Ester Rearrangements and Study of Their Ring-Opening Reactions. (2001) (0)
- Titanocene(III)-catalyzed conversion of N-(epoxyalkyl)anilinesinto indolines (2010) (0)
- Agonists Depends on the Permeant Ion Hippocampal L-Type Current Enhancement by Modulation of Single Channels Underlying (2015) (0)
- Agents targeted nitroxide (2009) (0)
- Dimethylzinc-Mediated Addition of Alkenyzirconocenes to α-Keto and α-Imino Esters. (2003) (0)
- Selective Amide Cleavage in Peptides Containing α,α‐Disubstituted α‐Amino Acids. (1987) (0)
- Novel Small Molecule Mitochondrial Targeted Nitroxides Mitigate Total Body Irradiation (2016) (0)
- 513 MITOCHONDRIAL-TARGETED FREE RADICAL SCAVENGER, XJB-5-131, PROTECTS THE BLADDER AGAINST RADIATION CYSTITIS WITHOUT AFFECTING TUMOUR SHRINKAGE (2022) (0)
- One‐Pot Synthesis of β‐Hydroxy‐1,3‐dienes via Allyltriphenylphosphonium Isomerization under Mild Conditions. (2006) (0)
- Kondru , as a Quantitative Probe of Molecular Chirality Atomic Contributions to the Optical Rotation Angle (2010) (0)
- Identification of Ionizing Irradiation Damage Mitigators by Evaluation of Clonogenic Survival of Human Umbilical Cord Blood Progenitor Cells (2012) (0)
- Copper(I)-Catalyzed Asymmetric Conjugate Addition of Organozirconocenes to N-Acyl Oxazolidinones. (1997) (0)
- The Antisignaling Agent SC- (cid:1)(cid:1)(cid:2) 9, 4-(Benzyl-(2-[(2,5-diphenyloxazole-4-carbonyl)amino]ethyl)carbamoyl)-2-decanoylaminobutyricAcid,IsaStructurallyUniquePhospholipidAnaloguewithPhospholipaseCInhibitoryActivity (2002) (0)
- Synthesis of Benzo[d]pyrrolo[1,2-a]imidazoles by Iminocyclopropane Rearrangement of C-Cyclopropylbenzimidazoles (2022) (0)
- Abstract 1220: Coordinated chemical-genetics approach identifies PTP4A3-mediated regulation of colon cancer cell migration and extracellular matrix interactions (2017) (0)
- Silver(I)-Catalyzed Addition of Zirconocenes to Epoxy Esters: A New Entry to 1,4-Dicarbonyl Compounds and Pyridazinones. (2000) (0)
- OGG1 and MUTYH repair activities promote telomeric 8-oxoguanine induced cellular senescence (2023) (0)
- Synthesis and Applications of Fluorous Silyl Protecting Groups with Improved Acid Stability. (1999) (0)
- A Short, Stereospecific Synthesis of Dihydrooxazoles from Serine and Threonine Derivatives. (1992) (0)
- Abstract 70: GS nitroxide (JP4-039) induces radiation resistance of conditional MnSOD tet/tet murine bone marrow stromal cells. (2013) (0)
- Mitochondrially-Targeted Drugs for the Prevention of Radiation Cystitis (2007) (0)
- Synthetic Studies Toward Diazonamide A. Preparation of the Benzofuranone-Indolyloxazole Fragment. (1998) (0)
- Abstract A83: Profiling potent, novel protein tyrosine phosphatase 4A3 small molecule inhibitors for ovarian cancer. (2016) (0)
- In Vitro Antimyeloma Effects of Inhibitors of the Heat Shock Protein 70 (Hsp70) Molecular Chaperone. (2007) (0)
- Small molecule PTP4A3 phosphatase inhibitors targeting acute myeloid leukemia (2020) (0)
- Faculty Opinions recommendation of An innovative method to study target protein-drug interactions by mass spectrometry. (2009) (0)
- Efficient Synthesis of 1,4‐Dihydro‐2H‐isoquinoline‐3,5,8‐triones via Cyclobutene Ring Expansion. (2000) (0)
- reporter assay Use of transcriptional synergy to augment sensitivity of a splicing (2006) (0)
- Synthesis of Functionalized Oxazolines and Oxazoles with DAST and Deoxo‐Fluor. (2000) (0)
- MMS350: A Novel Bifunctional Sulfoxide With Radiation Protection and Mitigation Properties (2012) (0)
- 1,3-Oxazoles and -Thiazoles in Natural Product Synthesis (2003) (0)
- JP4-039-Induced Amelioration of Mucositis and Abscopal Bone Marrow Suppression in Fanconi Anemia Fanca-/- Mice during Pencil Beam Scanning Proton Therapy (2019) (0)
- Silver(I)-Catalyzed Addition of Zirconocenes to Glycal Epoxides. A New Synthesis of α-C-Glycosides. (2005) (0)
- The Identification of a Novel TLR4 Inhibitor With Potent Anti-inflammatory Effects in Vivo Using a Combined in Silico and in Vivo Approach (2012) (0)
- Abstract 1459: PTP4A3 phosphatase is a novel drug target for epithelial ovarian cancer (2021) (0)
- A New Synthesis of α-Methylserine by Nucleophilic Ring-Opening of N-Sulfonyl Aziridines. (1995) (0)
- Total Synthesis of the Putative Structure (I) of the Marine Metabolite Trunkamide A. (1999) (0)
- Cryo-EM structure of human p97 bound to ADP (2016) (0)
- Targeting Hsp70 in Multiple Myeloma Induces Synergistic Cytotoxicity with Inhibitors of the Proteasome and of Hsp90 (2008) (0)
- Development of small molecule mitochondria-targeted antioxidants for radioprotection (2006) (0)
- 1‐Methoxy‐1‐(trimethylsilyloxy)propene (2001) (0)
- Synthesis and cytotoxic activity of bis-heterocycles analogs to Bengazoles (2003) (0)
- Organozirconocene‐Mediated Polyene Synthesis: Preparation of Asukamycin and Manumycin A Side Chains. (1997) (0)
- A potent and selective allosteric PTP4A3 phosphatase inhibitor enhances microvascular barrier function and inhibits human tumor cell growth. (2018) (0)
- Abstract A65: Combination of a thioxodihydroquinazolinone compound with cisplatin eliminates ovarian cancer stem cell-like cells (CSC-LCs) and shows preclinical potential (2018) (0)
- Effects of Radiation Mitigators JP4-039 and MMS350 on Gene Transcripts in Radiosensitive Fanconi Anemia Fancd2-/- (C57Bl/6) Bone Marrow Stromal Cells (2014) (0)
- Abstract 1404: Mitochondrial-targeted nitroxide JP4-039 ameliorates irradiation-induced delay in bone wound healing and inhibits orthotopic tumor growth (2010) (0)
- Bone Marrow Small Molecule Radioprotectors. (2007) (0)
- Irradiation-induced Inhibition of Bone Repair in SAMP6 and SAMR1 Mice (2012) (0)
- Inhibition of MKL-Profilin Signaling Axis by Small Molecule Strategies Impedes Endothelial Cell Migration and Angiogenesis (2017) (0)
- Shortest Synthesis of Lysergol and its Binding to 5-HT 1/2 Receptors (2022) (0)
- Total Body Irradiation of E13.5 Pregnant C57BL/6NTac Mice Retards Development of the Fetal Brain, Mitigated by Maternal Administration of JP4-039 on E14.5 (2017) (0)
- Disorazole C1: A potent antimitotic agent that induces premature senescence (2007) (0)
- Synthesis and Selective Functionalization of Thiadiazine 1,1-Dioxides with E ffi cacy in a Model of Huntington ’ s Disease § (2020) (0)
- Abstract 3210: Targeting PTP4A3 phosphatase in ovarian cancer with the potent noncompetitive inhibitor JMS-631-053 (2017) (0)
- Pharmacological profiling of phosphoinositide-3-kinase inhibitors as mitigators of ionizing radiation-induced cell death (2013) (0)
- Structural basis for the inhibition of botulinum neurotoxin serotype A by potent peptidomimetics (2013) (0)
- Parallel Synthesis of Oxazolines and Thiazolines by Tandem Condensation—Cyclodehydration of Carboxylic Acids with Amino Alcohols and Aminothiols. (2003) (0)
- Synthesis of Homoallylic Amines by Hydrozirconation—Imine Addition of Allenes. (2005) (0)
- Non-essential amino acid availability influences proteostasis and breast cancer cell survival during proteotoxic stress. (2023) (0)
- Erratum: Dimethylzinc-mediated additions of alkenylzirconocenes to aldimines. New methodologies for allylic amine and C-cyclopropylalkylamine syntheses (Journal of American Chemical Society (2003) 125 (761-768)) (2005) (0)
- Synthesis of the α-C-Glycoside Analogue of KRN7000 (2007) (0)
- Faculty Opinions recommendation of Rational design of bacitracin A derivatives by incorporating natural product derived heterocycles. (2006) (0)
- MMS350: A Water Soluble Radiation Protector and Mitigator (2013) (0)
- Presenting a Special Issue on "Medicinal Chemistry: From Targets to Therapies". (2020) (0)
- Thiophilic Ring‐Opening and Rearrangement Reactions of Epoxyketone Natural Products. (1998) (0)
- Faculty Opinions recommendation of Chemoenzymatic design of acidic lipopeptide hybrids: new insights into the structure-activity relationship of daptomycin and A54145. (2006) (0)
- Intraocular Injections of JP4-039 Protects the Retina from Radiation Retinopathy (2019) (0)
- Transition‐Metal‐Mediated Cascade Reactions: The Water‐Accelerated Carboalumination—Claisen Rearrangement—Carbonyl Addition Reaction. (2006) (0)
- Abstract 1475: Localization of mitochondrial targeted GS-nitroxide JP4-039 BODIPY FL conjugate during radioprotection and mitigationin vivo (2012) (0)
- Abstract 1460: The design and biological characterization of PTP4A-targeted chemodegraders (2021) (0)
- Small Molecule Inhibitors of Protein Kinase D: Early Development, Current Approaches, and Future Directions. (2022) (0)
- Mitigation of Irradiation-Induced Damage Using a Three-Drug Regiment (2019) (0)
- Abstract 228: Withaferin A downregulates tubulins and covalently binds β-tubulin at cysteine-303 in human breast cancer cells (2014) (0)
- 5-Hydroxy Indoles by Intramolecular Alkynol-Furan Diels-Alder Cycloaddition ‡ (2013) (0)
- Microwave assisted synthesis of biologically relevant selenosemicarbazones (2013) (0)
- Sequential Delivery of Ionizing Radiation Mitigators Based on Plasma, Intestine, and Bone Marrow Protein Signatures (2017) (0)
- A New Synthesis of Highly Functionalized Oxazoles. (1993) (0)
- Title : A novel small molecule targets androgen receptor and its splice variants in 1 castration-resistant prostate cancer (2019) (0)
- Faculty Opinions recommendation of Optimizing natural products by biosynthetic engineering: discovery of nonquinone Hsp90 inhibitors. (2008) (0)
- Selective Carbon—Carbon Bond Formations with Alkenylzirconocenes (2004) (0)
- Dissecting the antimitotic activities and cellular actions of the natural product disorazole C1 (2008) (0)
- Chemistry and Biology of Wortmannin (2005) (0)
- Exploiting small molecule and siRNA libraries to identify novel mechanisms for potential cancer therapeutic agents. (2008) (0)
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