Philip A Beachy
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Philip A Beachybiology Degrees
Biology
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Developmental Biology
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Molecular Biology
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Biochemistry
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Biology
Philip A Beachy's Degrees
- PhD Biochemistry Stanford University
- Bachelors Chemistry University of California, Berkeley
Why Is Philip A Beachy Influential?
(Suggest an Edit or Addition)Philip A Beachy's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function (1996) (3103)
- The Hedgehog and Wnt signalling pathways in cancer (2001) (1459)
- Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. (2002) (1444)
- Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development (1996) (1342)
- Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine (2000) (1324)
- Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours (2003) (1296)
- Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris (2018) (1181)
- Tissue repair and stem cell renewal in carcinogenesis (2004) (1180)
- Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer (2003) (1095)
- Hedgehog-Regulated Processing of Gli3 Produces an Anterior/Posterior Repressor Gradient in the Developing Vertebrate Limb (2000) (1054)
- Small molecule modulation of Smoothened activity (2002) (963)
- Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis (1995) (962)
- Teratogen-mediated inhibition of target tissue response to Shh signaling. (1998) (853)
- The Hedgehog Response Network: Sensors, Switches, and Routers (2004) (841)
- Medulloblastoma Growth Inhibition by Hedgehog Pathway Blockade (2002) (840)
- Patched acts catalytically to suppress the activity of Smoothened (2002) (830)
- Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog (1992) (625)
- Patterning activities of vertebrate hedgehog proteins in the developing eye and brain (1995) (602)
- Hedgehog signalling in prostate regeneration, neoplasia and metastasis (2004) (587)
- Autoproteolysis in hedgehog protein biogenesis. (1994) (570)
- Identification of Hedgehog Pathway Components by RNAi in Drosophila Cultured Cells (2003) (551)
- Molecular Genetics of the Bithorax Complex in Drosophila melanogaster (1983) (542)
- Induction of midbrain dopaminergic neurons by Sonic hedgehog (1995) (537)
- The product of hedgehog autoproteolytic cleavage active in local and long-range signalling (1995) (535)
- Hedgehog Patterning Activity: Role of a Lipophilic Modification Mediated by the Carboxy-Terminal Autoprocessing Domain (1996) (535)
- Essential role for Sonic hedgehog during hair follicle morphogenesis. (1999) (517)
- Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia (2009) (507)
- Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma (2007) (478)
- Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. (2010) (466)
- Skinny Hedgehog, an Acyltransferase Required for Palmitoylation and Activity of the Hedgehog Signal (2001) (465)
- Minimizing the risk of reporting false positives in large-scale RNAi screens (2006) (454)
- Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function. (2001) (442)
- The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye (1993) (420)
- A single-cell transcriptomic atlas characterizes ageing tissues in the mouse (2020) (412)
- Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia (2009) (409)
- Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response (2007) (404)
- Stromal response to Hedgehog signaling restrains pancreatic cancer progression (2014) (397)
- Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder (2011) (394)
- FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension. (2013) (359)
- Long-range sclerotome induction by sonic hedgehog: Direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway (1995) (356)
- Novel lipid modifications of secreted protein signals. (2004) (336)
- Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists. (2013) (331)
- Segmental distribution of bithorax complex proteins during Drosophila development (1985) (331)
- Products, genetic linkage and limb patterning activity of a murine hedgehog gene. (1994) (330)
- Hedgehog-Mediated Patterning of the Mammalian Embryo Requires Transporter-like Function of Dispatched (2002) (324)
- Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus (2009) (313)
- Prevalence of off-target effects in Drosophila RNA interference screens (2006) (304)
- Oxysterols Are Novel Activators of the Hedgehog Signaling Pathway in Pluripotent Mesenchymal Cells* (2007) (302)
- Mapping the Pairwise Choices Leading from Pluripotency to Human Bone, Heart, and Other Mesoderm Cell Types (2016) (294)
- Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector (2010) (294)
- Activity-Dependent Internalization of Smoothened Mediated by ß-Arrestin 2 and GRK2 (2004) (282)
- Nuclear Trafficking of Cubitus interruptus in the Transcriptional Regulation of Hedgehog Target Gene Expression (1999) (281)
- Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2. (2003) (278)
- Crystal Structure of a Hedgehog Autoprocessing Domain: Homology between Hedgehog and Self-Splicing Proteins (1997) (263)
- Identification of recurrent SMO and BRAF mutations in ameloblastomas (2014) (258)
- Genetics of ventral forebrain development and holoprosencephaly. (2000) (254)
- Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma (2011) (248)
- The Ihog Cell-Surface Proteins Bind Hedgehog and Mediate Pathway Activation (2006) (234)
- Identification of a cKit(+) colonic crypt base secretory cell that supports Lgr5(+) stem cells in mice. (2012) (233)
- Distinct expression and shared activities of members of the hedgehog gene family of Xenopus laevis. (1995) (229)
- A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis (2003) (224)
- Patterning of the embryonic forebrain (1998) (223)
- Open-label, exploratory phase II trial of oral itraconazole for the treatment of basal cell carcinoma. (2014) (223)
- The degree of variation in DNA sequence recognition among four Drosophila homeotic proteins. (1994) (203)
- Role of KEAP1/NRF2 and TP53 Mutations in Lung Squamous Cell Carcinoma Development and Radiation Resistance. (2017) (201)
- Extensive phosphorylation of Smoothened in Hedgehog pathway activation (2004) (198)
- A potential catalytic site revealed by the 1.7-Å crystal structure of the amino-terminal signalling domain of Sonic hedgehog (1995) (197)
- Interactions between Hedgehog proteins and their binding partners come into view. (2010) (195)
- Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched. (1999) (195)
- Defective cerebellar response to mitogenic Hedgehog signaling in Down's syndrome mice (2006) (193)
- Itraconazole Inhibits Enterovirus Replication by Targeting the Oxysterol-Binding Protein (2015) (193)
- Limb-patterning activity and restricted posterior localization of the amino-terminal product of Sonic hedgehog cleavage (1995) (191)
- A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis (2003) (177)
- Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response. (2013) (171)
- Cellular origin of bladder neoplasia and tissue dynamics of its progression to invasive carcinoma (2014) (169)
- Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched (2018) (163)
- Hedgehog signaling restrains bladder cancer progression by eliciting stromal production of urothelial differentiation factors. (2014) (162)
- Mediation of Sonic hedgehog-induced expression of COUP-TFII by a protein phosphatase. (1997) (158)
- The mode of Hedgehog binding to Ihog homologs is not conserved across different phyla (2008) (156)
- Aging hallmarks exhibit organ-specific temporal signatures (2020) (146)
- An Ultrabithorax protein binds sequences near its own and the Antennapedia P1 promoters (1988) (139)
- Optimal DNA sequence recognition by the Ultrabithorax homeodomain of Drosophila. (1991) (138)
- Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form. (2012) (136)
- Roles for Hedgehog signaling in androgen production and prostate ductal morphogenesis. (2004) (132)
- Multiple roles of cholesterol in hedgehog protein biogenesis and signaling. (1997) (131)
- Structure and expression of a family of Ultrabithorax mRNAs generated by alternative splicing and polyadenylation in Drosophila. (1989) (130)
- Smoothened stimulation by membrane sterols drives Hedgehog pathway activity (2019) (127)
- Genetic and biochemical definition of the Hedgehog receptor. (2010) (122)
- Differential DNA sequence recognition is a determinant of specificity in homeotic gene action. (1992) (121)
- Cholesterol modification of proteins. (2000) (111)
- Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly. (2005) (105)
- Rapid, direct activity assays for Smoothened reveal Hedgehog pathway regulation by membrane cholesterol and extracellular sodium (2017) (103)
- Structure of a heparin-dependent complex of Hedgehog and Ihog (2006) (95)
- Regulation and products of the Ubx domain of the bithorax complex. (1985) (95)
- Defective cerebellar response to mitogenic Hedgehog signaling in Down [corrected] syndrome mice. (2006) (89)
- Cilia-Associated Oxysterols Activate Smoothened. (2018) (89)
- Ultrabithorax protein is necessary but not sufficient for full activation of decapentaplegic expression in the visceral mesoderm. (1995) (89)
- Dally-like core protein and its mammalian homologues mediate stimulatory and inhibitory effects on Hedgehog signal response (2010) (86)
- Ageing hallmarks exhibit organ-specific temporal signatures (2020) (84)
- Effects of Combined Treatment With Arsenic Trioxide and Itraconazole in Patients With Refractory Metastatic Basal Cell Carcinoma. (2016) (74)
- Patterning of the neural ectoderm of Xenopus laevis by the amino-terminal product of hedgehog autoproteolytic cleavage. (1995) (72)
- Pharmacological rescue of diabetic skeletal stem cell niches (2017) (69)
- The role of ciliary trafficking in Hedgehog receptor signaling (2015) (67)
- Cooperative binding of an Ultrabithorax homeodomain protein to nearby and distant DNA sites (1993) (67)
- Structure of the protein core of the glypican Dally-like and localization of a region important for hedgehog signaling (2011) (66)
- Mending and malignancy (2004) (66)
- Truncating loss-of-function mutations of DISP1 contribute to holoprosencephaly-like microform features in humans (2009) (65)
- Differential requirements for shh in mammary tissue and hair follicle morphogenesis. (2002) (63)
- A genomewide screen for components of the RNAi pathway in Drosophila cultured cells (2006) (62)
- Control of inflammation by stromal Hedgehog pathway activation restrains colitis (2016) (62)
- Targeted inhibition of hedgehog signaling by cyclopamine prodrugs for advanced prostate cancer. (2008) (58)
- Misexpression of Sox9 in mouse limb bud mesenchyme induces polydactyly and rescues hypodactyly mice. (2007) (54)
- Endogenous B-ring oxysterols inhibit the Hedgehog component Smoothened in a manner distinct from cyclopamine or side-chain oxysterols (2016) (53)
- The Stromal Niche for Epithelial Stem Cells: A Template for Regeneration and a Brake on Malignancy. (2017) (51)
- Control of Drosophila tracheal branching by the novel homeodomain gene unplugged, a regulatory target for genes of the bithorax complex. (1995) (50)
- Stromal Gli2 activity coordinates a niche signaling program for mammary epithelial stem cells (2017) (50)
- Expression of a novel Toll-like gene spans the parasegment boundary and contributes to hedgehog function in the adult eye of Drosophila (1994) (42)
- Patterning Axon Targeting of Olfactory Receptor Neurons by Coupled Hedgehog Signaling at Two Distinct Steps (2010) (40)
- Single-cell transcriptomic characterization of 20 organs and tissues from individual mice creates a Tabula Muris (2017) (40)
- Localized JNK signaling regulates organ size during development (2016) (38)
- The novel homeodomain gene buttonless specifies differentiation and axonal guidance functions of Drosophila dorsal median cells. (1994) (33)
- Gated Visual Input to the Central Auditory System (2002) (31)
- Spatially restricted Hedgehog signaling regulates HGF-induced branching of the adult prostate (2014) (30)
- Neuronal delivery of Hedgehog directs spatial patterning of taste organ regeneration (2017) (30)
- A molecular view of the Ultrabithorax homeotic gene of Drosophila. (1990) (29)
- Molecular hallmarks of heterochronic parabiosis at single-cell resolution (2020) (28)
- Erratum: A defective response to hedgehog signaling in disorders of cholesterol biosynthesis (Nature Genetics (2003) 33 (508-513)) (2003) (26)
- Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5 (2015) (26)
- Overexpression of a Rrp1 transgene reduces the somatic mutation and recombination frequency induced by oxidative DNA damage in Drosophila melanogaster. (1996) (22)
- Cell types of origin of the cell-free transcriptome (2022) (20)
- Hedgehog mediated degradation of Ihog adhesion proteins modulates cell segregation in Drosophila wing imaginal discs (2017) (20)
- Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit (2020) (18)
- Deconstructing tumor heterogeneity: the stromal perspective (2020) (18)
- Transcriptional activation by extradenticle in the Drosophila visceral mesoderm. (2006) (18)
- Hedgehogs, flies, Wnts and MYCs: the time has come for many things in medulloblastoma. (2011) (17)
- A Comparison of Ci/Gli Activity as Regulated by Sufu in Drosophila and Mammalian Hedgehog Response (2015) (16)
- Expression and regulation of chicken fibroblast growth factor homologous factor (FHF)‐4 during craniofacial morphogenesis (2001) (14)
- pH-dependent enhancement of DNA binding by the ultrabithorax homeodomain. (1996) (13)
- Simultaneous Measurement of Smoothened Entry Into and Exit From the Primary Cilium (2014) (13)
- Dispatched uses Na+ flux to power release of lipid-modified Hedgehog (2021) (11)
- erratum: Patched acts catalytically to suppress the activity of Smoothened (2002) (6)
- Erratum: Defective cerebellar response to mitogenic Hedgehog signaling in Down's syndrome mice (Proceedings of the National Academy of Sciences of the United States of America (January 31, 2006) 103, 5 (1452-1456) 10.1073/pnas.0510750103)) (2006) (6)
- Hedgehog pathway activation through conformational blockade of the Patched sterol conduit (2019) (4)
- Adversarial domain translation networks for integrating large-scale atlas-level single-cell datasets (2022) (3)
- DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) (2012) (3)
- Abstract #5582: Itraconazole as a novel Hedgehog pathway antagonist in cancer therapy (2009) (3)
- Stromal Gli 2 activity coordinates a niche signaling program for mammary epithelial stem cells (2017) (3)
- FK-506 (Tacrolimus), Identified In A High Throughput Screen To Increase Bmprii Signaling, Prevents Pulmonary Arterial Hypertension (PAH) In Mice With Endothelial Bmprii Deletion (2011) (2)
- LB783 Topical Itraconazole inhibits the Hedgehog signaling pathway and reduces tumor development and size in murine models (2016) (2)
- Dispatched conformational dynamics couples transmembrane Na+ flux to release of lipid-modified Hedgehog signal (2020) (2)
- Erratum: Cellular origin of bladder neoplasia and tissue dynamics of its progression to invasive carcinoma (2014) (2)
- Developmental biology: Drosophila proteins pave the way to gene mutations (1985) (2)
- Exploratory Phase II Trial of Oral Itraconazole for the Treatment of Basal Cell Carcinoma (2014) (1)
- 906 CKit/CD117 Identifies a Colonic Paneth-Like Cell That Contributes to the Stem Cell Niche and Regulates Crypt Homeostasis (2012) (1)
- Abstract LB-223: An open-label, exploratory phase II study of oral itraconazole for the treatment of basal cell carcinoma (2012) (1)
- Abstract 5644: Itraconazole and arsenic trioxide inhibit hedgehog pathway activation and tumor growth associated with acquired resistance to vismodegib. (2013) (1)
- Corrigendum: Identification of recurrent SMO and BRAF mutations in ameloblastomas (2014) (1)
- Hedgehog receptor Patched (PTCH1) in complex with conformation selective nanobody TI23 (2021) (1)
- MP57-04 HUMAN BLADDER TRANSCRIPTOME AT SINGLE CELL RESOLUTION IN DISEASE-FREE AND TUMOR-BEARING TISSUE (2019) (1)
- Modulators of hedgehog signaling pathways, compositions and related uses (2003) (1)
- Targeted disruption of Sonic hedgehog reveals an essential role in hair follicle morphogenesis (1998) (1)
- A POTENTIAL CATALYTIC SITE WITHIN THE AMINO-TERMINAL SIGNALLING DOMAIN OF SONIC HEDGEHOG (1996) (1)
- LMO2 is critical for early metastatic events in breast cancer (2021) (1)
- 597: Requirement for Autonomous Hedgehog Signal Response in Prostate Cancer Metastases (2004) (1)
- Novel Lipid Modifications of Secreted Signaling Proteins (2003) (0)
- Crystal structure of active Smoothened bound to SAG21k, cholesterol, and NbSmo8 (2019) (0)
- The hedgehog family of secreted signaling proteins represents a recent addition to the known repertoire of molecules employed by vertebrates in the establishment of embryonic pattern. Originally identified by Nüsslein-Volhard and Wieschaus (1980), the hedgehog gene functions in Drosophila (1995) (0)
- 530 POSTER Inhibition of hedgehog signaling by cyclopamine prodrug: targeted therapy for advance prostate cancer (2006) (0)
- Hsd11β2 Is Enriched in Medulloblastoma and Generates Ciliary Oxysterols to Stimulate Hedgehog Signaling (2016) (0)
- Hedgehog mediated degradation of Ihog adhesion proteins modulates cell segregation in Drosophila wing imaginal discs (2017) (0)
- Cryo-EM structure of murine Dispatched NNN mutant (2021) (0)
- An UItrabithorax Protein Binds Sequences Near Its Own and the Anfennapedia PI Promoters (2003) (0)
- MOLECULAR CHARACTERIZATION OF THE MURINE URINARY BLADDER USING SINGLE CELL RNA SEQUENCING: MP81‐10 (2018) (0)
- Year : 2002 Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function (2006) (0)
- Multiple roles of cholesterol in hedgehog signaling (2000) (0)
- Genetic and biochemical definition of the Hedgehog receptor Material Supplemental (2009) (0)
- 17-kDA fragment of hedgehog C-terminal autoprocessing domain (1997) (0)
- Publisher Correction: Cell types of origin of the cell-free transcriptome (2022) (0)
- Abstract 3436: Ameloblastoma driver mutations revealed by next-generation sequencing of formalin-fixed paraffin-embedded specimens (2014) (0)
- Cryo-EM structure of murine Dispatched in complex with Sonic hedgehog (2021) (0)
- Cilia-Associated Oxystero ls Activate Smoothened Graphical Abstract Highlights (2018) (0)
- Identification of a minority population of LMO2+ breast cancer cells that integrate into the vasculature and initiate metastasis. (2022) (0)
- Ameloblastoma driver mutations revealed by next‐generation sequencing of formalin‐fixed paraffin‐embedded specimens (1048.18) (2014) (0)
- Philip Beachy (2008) (0)
- Cryo-EM structure of murine Dispatched 'R' conformation (2021) (0)
- 788 Evidence for an Evolutionarily-Conserved Mechanism Regulating Stem and Progenitor Cell Numbers in the Regenerative Response to Ulcerative Colitis (2010) (0)
- Reviewer list for 1995 (1995) (0)
- Modulateurs de voies de signalisation hedgehog, compositions et utilisations associees (2003) (0)
- Abstract SY05-02: Hedgehog/wnt feedback supports regenerative proliferation of epithelial stem cells in bladder (2011) (0)
- second key area of interest will be establishing whether other pathogens, and possibly also symbionts, use similar mechanisms to colonize their plant hosts. A (2002) (0)
- Deletion of host acyl-coA binding protein alters membrane curvature and inhibits genomic replication of a positive-strand RNA virus (2010) (0)
- Acknowledgment of reviewers 2014 (2015) (0)
- Cellular and molecular mechanisms of Hedgehog signalling. (2023) (0)
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What Schools Are Affiliated With Philip A Beachy?
Philip A Beachy is affiliated with the following schools:
