Philip Leder

Q: What Schools Are Affiliated With Philip Leder

Philip Leder is affiliated with the following schools: Hebrew University of Jerusalem, Kyoto University, Harvard University

Philip Leder's AcademicInfluence.com Rankings

Philip Leder

Biology

#206

World Rank

#377

Historical Rank

#120

USA Rank

Genetics

#34

World Rank

#55

Historical Rank

#24

USA Rank

biology Degrees

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Biology

Philip Leder's Degrees

Doctorate Medicine Harvard University

Why Is Philip Leder Influential?

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According to Wikipedia, Philip Leder was an American geneticist. Early life and education Leder was born in Washington, D.C., and studied at Harvard University, graduating in 1956. In 1960, he graduated from Harvard Medical School and completed his medical residency at the University of Minnesota.

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Philip Leder's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. (1972) (4776)
Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor (1991) (2343)
Mice Lacking p21 CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control (1995) (2185)
Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor (1983) (1962)
Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. (2006) (1482)
Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells. (1982) (1328)
The hematopoietic growth factor KL is encoded by the SI locus and is the ligand of the c-kit receptor, the gene product of the W locus (1990) (1219)
Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene (1988) (1197)
RNA Codewords and Protein Synthesis (1964) (1074)
Fibroblast Growth Factor Receptor 3 Is a Negative Regulator of Bone Growth (1996) (1052)
The Death Domain Kinase RIP Mediates the TNF-Induced NF-κB Signal (1998) (985)
RIP: A novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death (1995) (978)
c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities (1988) (958)
Structure of the human immunoglobulin μ locus: Characterization of embryonic and rearranged J and D genes (1981) (914)
Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes (1984) (847)
Murine interleukin-4 displays potent anti-tumor activity in vivo (1989) (831)
Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: Synergistic action of oncogenes in vivo (1987) (779)
The kit ligand: A cell surface molecule altered in steel mutant fibroblasts (1990) (769)
Murine FGFR-1 is required for early postimplantation growth and axial organization. (1994) (766)
Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the SId mutant (1991) (751)
Enhancer-dependent expression of human kappa immunoglobulin genes introduced into mouse pre-B lymphocytes by electroporation. (1984) (746)
Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia (1996) (718)
Butyric acid, a potent inducer of erythroid differentiation in cultured erythroleukemic cells (1975) (630)
Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells (1992) (621)
The human c-myc oncogene: Structural consequences of translocation into the igh locus in Burkitt lymphoma (1983) (600)
Immunoglobulin gene rearrangement and cell surface antigen expression in acute lymphocytic leukemias of T cell and B cell precursor origins. (1983) (596)
A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints. (2008) (592)
Translocations among antibody genes in human cancer. (1983) (569)
Developmental hierarchy of immunoglobulin gene rearrangements in human leukemic pre-B-cells. (1981) (567)
Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction. (1998) (564)
Targeted Disruption of the Chemokine Eotaxin Partially Reduces Antigen-induced Tissue Eosinophilia (1997) (560)
An eosinophil-dependent mechanism for the antitumor effect of interleukin-4. (1992) (550)
Pleiotropic defects in ataxia-telangiectasia protein-deficient mice. (1996) (519)
Functional role for c-myc in mitogenic response to platelet-derived growth factor (1984) (503)
The death domain kinase RIP mediates the TNF-induced NF-kappaB signal. (1998) (500)
The IP-10 chemokine binds to a specific cell surface heparan sulfate site shared with platelet factor 4 and inhibits endothelial cell proliferation (1995) (487)
Parental legacy determines methylation and expression of an autosomal transgene: A molecular mechanism for parental imprinting (1987) (463)
IP-10, a -C-X-C- chemokine, elicits a potent thymus-dependent antitumor response in vivo (1993) (422)
Differentiation in erythroleukemic cells and their somatic hybrids. (1975) (421)
Active anaphylaxis in IgE-deficient mice (1994) (420)
Casein kinase II alpha transgene-induced murine lymphoma: relation to theileriosis in cattle (1995) (411)
IL-4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice (1990) (400)
Consequences of widespread deregulation of the c-myc gene in transgenic mice: Multiple neoplasms and normal development (1986) (398)
Murine eotaxin: an eosinophil chemoattractant inducible in endothelial cells and in interleukin 4-induced tumor suppression. (1995) (364)
Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene. (1979) (349)
Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments (1980) (344)
Formin-2, polyploidy, hypofertility and positioning of the meiotic spindle in mouse oocytes (2002) (320)
Human immunoglobulin heavy chain genes map to a region of translocations in malignant B lymphocytes. (1982) (313)
Chromatin structure and protein binding in the putative regulatory region of the c-myc gene in burkitt lymphoma (1984) (310)
Clustered arrangement of immunoglobulin λ constant region genes in man (1981) (305)
Tal‐1 induces T cell acute lymphoblastic leukemia accelerated by casein kinase IIalpha. (1996) (298)
Allelic exclusion in transgenic mice that express the membrane form of immunoglobulin mu. (1987) (296)
EK2 derivatives of bacteriophage lambda useful in the cloning of DNA from higher organisms: the lambdagtWES system. (1977) (295)
Human immunoglobulin κ light-chain genes are deleted or rearranged in λ-producing B cells (1981) (294)
v-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: effects of phorbol esters and retinoic acid. (1990) (293)
A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity. (1998) (291)
The sequence of the chromosomal mouse β-globin major gene: Homologies in capping, splicing and poly(A) sites (1978) (284)
An inherited limb deformity created by insertional mutagenesis in a transgenic mouse (1985) (281)
Initiation of protein synthesis II. A convenient assay for the ribosome-dependent synthesis of N-formyl-C14-methionylpuromycin. (1966) (276)
Evolution of human immunoglobulin kappa J region genes. (1982) (272)
Cutaneous lymphoproliferation and lymphomas in interleukin 7 transgenic mice (1993) (271)
RNA codewords and protein synthesis, VII. On the general nature of the RNA code. (1965) (269)
Activation and somatic mutation of the translocated c-myc gene in Burkitt lymphoma cells (1984) (263)
Nuclear localization and DNA binding properties of a protein expressed by human c-myc oncogene. (1984) (260)
Chromosomal location of human kappa and lambda immunoglobulin light chain constant region genes (1982) (256)
The int‐2 gene product acts as an epithelial growth factor in transgenic mice. (1990) (255)
The Werner Syndrome Gene Product Co-purifies with the DNA Replication Complex and Interacts with PCNA and Topoisomerase I* (1999) (255)
Arginine Methylation Inhibits the Binding of Proline-rich Ligands to Src Homology 3, but Not WW, Domains* (2000) (251)
Plasmacytoid dendritic cells activate lymphoid-specific genetic programs irrespective of their cellular origin. (2004) (250)
Leukemia inhibitory factor is expressed by the preimplantation uterus and selectively blocks primitive ectoderm formation in vitro. (1992) (249)
Loss of Daxx, a promiscuously interacting protein, results in extensive apoptosis in early mouse development. (1999) (241)
Parental-specific methylation of an imprinted transgene is established during gametogenesis and progressively changes during embryogenesis (1991) (240)
atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity (1997) (235)
The evolution and sequence comparison of two recently diverged mouse chromosomal β-globin genes (1979) (234)
Ligand specificity and heparin dependence of fibroblast growth factor receptors 1 and 3. (1992) (233)
Direct induction of T lymphocyte-specific gene expression by the mammalian Notch signaling pathway. (2002) (226)
The cytomegalovirus enhancer: a pan-active control element in transgenic mice (1990) (221)
Splicing and the formation of stable RNA (1979) (220)
FBP WW domains and the Abl SH3 domain bind to a specific class of proline‐rich ligands (1997) (220)
The complete sequence of a chromosomal mouse α-globin gene reveals elements conserved throughout vertebrate evolution (1979) (219)
The arrangement and rearrangement of antibody genes (1978) (217)
neu and ras initiate murine mammary tumors that share genetic markers generally absent in c-myc and int-2-initiated tumors. (1994) (216)
A κ-immunoglobulin gene is formed by site-specific recombination without further somatic mutation (1979) (214)
Constitutive and allergen-induced expression of eotaxin mRNA in the guinea pig lung (1995) (211)
A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth. (2002) (208)
Stage-specific apoptosis, developmental delay, and embryonic lethality in mice homozygous for a targeted disruption in the murine Bloom's syndrome gene. (1998) (207)
Binary system for regulating transgene expression in mice: targeting int-2 gene expression with yeast GAL4/UAS control elements. (1991) (203)
'Formins': proteins deduced from the alternative transcripts of the limb deformity gene (1990) (201)
Eotaxin Triggers Eosmophil-Selective Chemotaxis and Calcium Flux via a Distinct Receptor and Induces Pulmonary Eosinophilia in the Presence of Interleukin 5 in Mice (1996) (199)
Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice. (1995) (199)
Intervening sequence of DNA identified in the structural portion of a mouse beta-globin gene. (1978) (198)
Globin messenger-RNA induction during erythroid differentiation of cultured leukemia cells. (1972) (187)
Human immunoglobulin D segments encoded in tandem multigenic families (1981) (187)
The Neuroendocrine Protein 7B2 Is Required for Peptide Hormone Processing In Vivo and Provides a Novel Mechanism for Pituitary Cushing’s Disease (1999) (185)
Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice. (1997) (179)
β-catenin is a downstream effector of Wnt-mediated tumorigenesis in the mammary gland (2001) (176)
Processed genes: a dispersed human immunoglobulin gene bearing evidence of RNA-type processing (1982) (171)
The nucleotide sequence of a 5.5-kilobase DNA segment containing the mouse kappa immunoglobulin J and C region genes. (1981) (170)
Murine c‐mpl: a member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal. (1993) (169)
Ras pathway signals are required for notch-mediated oncogenesis (2000) (169)
Cloning specific segments of the mammalian genome: bacteriophage lambda containing mouse globin and surrounding gene sequences. (1977) (161)
Mutations of immunoglobulin transmembrane and cytoplasmic domains: Effects on intracellular signaling and antigen presentation (1990) (159)
Antibodies to human c-myc oncogene product: evidence of an evolutionarily conserved protein induced during cell proliferation. (1984) (159)
The intervening sequence of a mouse beta-globin gene is transcribed within the 15S beta-globin mRNA precursor. (1978) (158)
The human homologs of the raf (mil) oncogene are located on human chromosomes 3 and 4. (1984) (155)
Fibroblast growth factor receptor-1 (FGFR-1) is essential for normal neural tube and limb development. (1997) (153)
RNAi reveals anti-apoptotic and transcriptionally repressive activities of DAXX (2003) (151)
Wnt-10b directs hypermorphic development and transformation in mammary glands of male and female mice (1997) (150)
Mat-8, a Novel Phospholemman-like Protein Expressed in Human Breast Tumors, Induces a Chloride Conductance in Xenopus Oocytes (*) (1995) (150)
Mitochondriotoxic compounds for cancer therapy (2006) (144)
Signal transduction pathways activated and required for mammary carcinogenesis in response to specific oncogenes (1998) (142)
Structure and expression of the human immunoglobulin lambda genes (1990) (142)
Inactivation of mouse Hus1 results in genomic instability and impaired responses to genotoxic stress. (2000) (142)
Transgenes expressing the Wnt-1 and int-2 proto-oncogenes cooperate during mammary carcinogenesis in doubly transgenic mice (1992) (141)
Unusual alpha-globin-like gene that has cleanly lost both globin intervening sequences. (1980) (140)
NDF/heregulin induces persistence of terminal end buds and adenocarcinomas in the mammary glands of transgenic mice. (1996) (139)
The Mouse formin (Fmn) Gene: Abundant Circular RNA Transcripts and Gene-Targeted Deletion Analysis (1998) (138)
An embryonically expressed gene is a target for c-Myc regulation via the c-Myc-binding sequence. (1992) (138)
Purification and cloning of a mouse ribosomal gene fragment in coliphage lambda. (1977) (135)
Purification and properties of biologically active messenger RNA for a myeloma light chain. (1972) (131)
A conserved sequence in the immunoglobulin Jκ–Cκ intron: possible enhancer element (1983) (131)
Transcription and promoter usage of the myc gene in normal somatic and spermatogenic cells. (1984) (130)
A differential display strategy identifies Cryptic, a novel EGF-related gene expressed in the axial and lateral mesoderm during mouse gastrulation. (1997) (130)
In vitro synthesis of DNA complementary to purified rabbit globin mRNA (RNA-dependent DNA polymerase-reticulocyte-hemoglobin-density gradient centrifugation-oligo(dT) primer). (1972) (128)
Normal human B cells display ordered light chain gene rearrangements and deletions (1982) (127)
Transgenic mice bearing the human c-myc gene activated by an immunoglobulin enhancer: a pre-B-cell lymphoma model. (1988) (127)
A mutant immunoglobulin light chain is formed by aberrant DNA- and RNA-splicing events (1980) (126)
Dispersion of α-like globin genes of the mouse to three different chromosomes (1981) (122)
A variant translocation places the λ immunoglobulin genes 3′ to the c-myc oncogene in Burkitt's lymphoma (1984) (120)
Variable amplification of immunoglobulin λ light-chain genes in human populations (1983) (119)
Association of Elevated Protein Kinase CK2 Activity with Aggressive Behavior of Squamous Cell Carcinoma of the Head and Neck (1995) (117)
RIP and FADD: two "death domain"-containing proteins can induce apoptosis by convergent, but dissociable, pathways. (1996) (117)
SV40 recombinants carrying rabbit β-globin gene coding sequences (1979) (116)
Insertional mutagenesis identifies a member of the Wnt gene family as a candidate oncogene in the mammary epithelium of int-2/Fgf-3 transgenic mice. (1995) (116)
Disruption of formin-encoding transcripts in two mutant limb deformity alleles (1990) (113)
Transcription of mouse kappa chain genes: implications for allelic exclusion. (1980) (113)
Duplication and deletion in the human immunoglobulin ϵ genes (1982) (112)
On the Coding of Genetic Information (1963) (112)
Multiple related immunoglobulin variable-region genes identified by cloning and sequence analysis. (1978) (111)
Translation and translocation of defined RNA messengers. (1969) (110)
Expression of the chromosomal mouse βmaj-globin gene cloned in SV40 (1979) (110)
Globin gene expression in cultured erythroleukemic cells. (1974) (108)
Animal models of human disease. Pathology and molecular biology of spontaneous neoplasms occurring in transgenic mice carrying and expressing activated cellular oncogenes. (1989) (106)
Hus1 Acts Upstream of Chk1 in a Mammalian DNA Damage Response Pathway (2002) (105)
Polydactylous limbs in Strong's Luxoid mice result from ectopic polarizing activity. (1995) (103)
Two kappa immunoglobulin genes are expressed in the myeloma S107 (1981) (102)
A comparison of two cloned mouse β-globin genes and their surrounding and intervening sequences (1978) (102)
Expression of LIF in transgenic mice results in altered thymic epithelium and apparent interconversion of thymic and lymph node morphologies. (1994) (101)
Organization and complete sequence of identical embryonic and plasmacytoma kappa V-region genes. (1980) (98)
Differentiation of erythroleukemic cells in the presence of inhibitors of DNA synthesis (1975) (98)
Loss of atm radiosensitizes multiple p53 null tissues. (1998) (98)
Keratinocyte growth factor induces mammary and prostatic hyperplasia and mammary adenocarcinoma in transgenic mice. (1996) (97)
Transgenic oncogene mice. Tumor phenotype predicts genotype. (1991) (95)
Cloning of the mast cell protease, RMCP II. Evidence for cell-specific expression and a multi-gene family. (1987) (94)
Homeodomain-Interacting Protein Kinase 1 Modulates Daxx Localization, Phosphorylation, and Transcriptional Activity (2003) (93)
Tracing lymphopoiesis with the aid of a pTα-controlled reporter gene (2002) (92)
A novel alteration in the structure of an activated c-myc gene in a variant t(2;8) burkitt lymphoma (1984) (92)
Human and rat mast cell high-affinity immunoglobulin E receptors: characterization of putative alpha-chain gene products. (1988) (91)
Genetic interactions between atm and p53 influence cellular proliferation and irradiation-induced cell cycle checkpoints. (1997) (90)
Human MCF10A Mammary Epithelial Cells Undergo Apoptosis following Actin Depolymerization That Is Independent of Attachment and Rescued by Bcl-2 (2001) (90)
The MMTV/c-myc transgene and p53 null alleles collaborate to induce T-cell lymphomas, but not mammary carcinomas in transgenic mice. (1995) (88)
Identification of a cytoplasmic, phorbol ester-inducible isoform of protein tyrosine phosphatase epsilon. (1995) (87)
High capacity gel preparative electrophoresis for purification of fragments of genomic DNA. (1978) (87)
A Novel Pro-Arg Motif Recognized by WW Domains* (2000) (85)
Humoral immune functions in IL-4 transgenic mice. (1991) (84)
Deformylation and protein biosynthesis. (1969) (83)
Comparison of cloned mouse alpha- and beta-globin genes: conservation of intervening sequence locations and extragenic homology. (1978) (83)
Mouse globin system: a functional and evolutionary analysis. (1980) (79)
Critical Role for Mouse Hus1 in an S-Phase DNA Damage Cell Cycle Checkpoint (2003) (77)
Localization of human variable and constant region immunoglobulin heavy chain genes on subtelomeric band q32 of chromosome 14. (1982) (76)
Variation in the crossover point of kappa immunoglobulin gene V-J recombination: Evidence from a cryptic gene (1980) (75)
A cytoskeleton-based functional genetic screen identifies Bcl-xL as an enhancer of metastasis, but not primary tumor growth (2004) (75)
The limb deformity gene is required for apical ectodermal ridge differentiation and anteroposterior limb pattern formation. (1989) (75)
SV40 recombinants carrying a functional RNA splice junction and polyadenylation site from the chromosomal mouse βmaj globin gene (1979) (74)
Regulation of genomic imprinting by gametic and embryonic processes. (1995) (74)
Clustered arrangement of immunoglobulin lambda constant region genes in man. (1981) (74)
A human immunoglobulin gene reduces the incidence of lymphomas in c-Myc-bearing transgenic mice (1988) (74)
The c-myc gene encodes superimposed RNA polymerase II and III promoters (1987) (74)
A genome-wide RNA interference screen identifies putative chromatin regulators essential for E2F repression (2007) (73)
Formin isoforms are differentially expressed in the mouse embryo and are required for normal expression of fgf-4 and shh in the limb bud. (1995) (72)
MEK1 signaling mediates transformation and metastasis of EpH4 mammary epithelial cells independent of an epithelial to mesenchymal transition. (2002) (70)
Evolutionarily conserved regions of the human c-myc protein can be uncoupled from transforming activity. (1987) (69)
Role of an RNA cleavage/poly(A) addition site in the production of membrane-bound and secreted IgM mRNA. (1985) (69)
Protein synthesis directed by encephalomyocarditis virus RNA: properties of a transfer RNA-dependent system. (1971) (69)
Differential expression of alpha- and beta-globin genes during differentiation of cultured erythroleukemic cells. (1975) (67)
Formin-2, a novel formin homology protein of the cappuccino subfamily, is highly expressed in the developing and adult central nervous system (2000) (66)
Translocations among antibody genes in human cancer. (2019) (66)
A processed human immunoglobulin epsilon gene has moved to chromosome 9. (1982) (66)
RNA codewords and protein synthesis, 8. Nucleotide sequences of synonym codons for arginine, valine, cysteine, and alanine. (1965) (66)
Tumorigenic effect of nonfunctional p53 or p21 in mice mutant in the Werner syndrome helicase. (2001) (66)
Evolutionary approach to the question of immunoglobulin heavy chain switching: evidence from cloned human and mouse genes. (1980) (65)
Safer derivatives of bacteriophage λgt.λC for use in cloning of recombinant DNA molecules (1976) (64)
F16, a Mitochondriotoxic Compound, Triggers Apoptosis or Necrosis Depending on the Genetic Background of the Target Carcinoma Cell (2004) (64)
Identification of three new Ig lambda-like genes in man (1986) (63)
RNA CODEWORDS AND PROTEIN SYNTHESIS. II. NUCLEOTIDE SEQUENCE OF A VALINE RNA CODEWORD. (1964) (62)
Trans-acting elements modulate expression of the human c-myc gene in Burkitt lymphoma cells. (1986) (61)
Protein kinase expression during murine mammary development. (2000) (61)
Improved derivative of a phage λ EK2 vector for cloning recombinant DNA (1976) (60)
Expression of the Mouse Pre-T Cell Receptor α Gene Is Controlled by an Upstream Region Containing a Transcriptional Enhancer (1999) (59)
Benign prostatic hyperplasia in a transgenic mouse: a new hormonally sensitive investigatory model. (1993) (59)
Brain tumours and lymphomas in transgenic mice that carry HTLV-I LTR/c-myc and Ig/tax genes. (1992) (59)
The Upstream Enhancer Is Necessary and Sufficient for the Expression of the Pre-T Cell Receptor α Gene in Immature T Lymphocytes (2001) (59)
Human immunoglobulin kappa light-chain genes are deleted or rearranged in lambda-producing B cells. (1981) (57)
Mapping of the human Blym-1 transforming gene activated in Burkitt lymphomas to chromosome 1. (1984) (57)
Multiple tumor types appear in a transgenic mouse with the ras oncogene. (1993) (56)
A Network of Conserved Damage Survival Pathways Revealed by a Genomic RNAi Screen (2009) (56)
Isolation of a Murine Homologue of the Drosophila neuralized Gene, a Gene Required for Axonemal Integrity in Spermatozoa and Terminal Maturation of the Mammary Gland (2001) (55)
Immunoglobulin double-isotype expression by trans-mRNA in a human immunoglobulin transgenic mouse. (1989) (54)
Mutational analysis of a critical signaling domain of the human interleukin 4 receptor. (1994) (54)
Association between a transposed α-globin pseudogene and retrovirus-like elements in the BALB/c mouse genome (1982) (53)
An association between globin messenger RNA and 60S RNA derived from Friend leukemia virus. (1974) (53)
Multiple immunoglobulin switch region homologies outside the heavy chain constant region locus (1981) (52)
Mutation of the Murine Bloom's Syndrome Gene Produces Global Genome Destabilization (2006) (51)
Formin-1 protein associates with microtubules through a peptide domain encoded by exon-2. (2006) (51)
The elongation reactions in protein synthesis. (1973) (50)
Organization of immunoglobulin genes: reiteration frequency of the mouse kappa chain constant region gene. (1974) (49)
In situ hybridization reveals co-expression of embryonic and adult alpha globin genes in the earliest murine erythrocyte progenitors. (1992) (49)
Cytoplasmic tail deletion converts membrane immunoglobulin to a phosphatidylinositol-linked form lacking signaling and efficient antigen internalization functions. (1991) (48)
Formin 1-Isoform IV Deficient Cells Exhibit Defects in Cell Spreading and Focal Adhesion Formation (2008) (48)
A translocated human c-myc oncogene is altered in a conserved coding sequence. (1986) (48)
A bifunctional targeted peptide that blocks HER-2 tyrosine kinase and disables mitochondrial function in HER-2-positive carcinoma cells. (2005) (47)
Chromosome instability and tumor predisposition inversely correlate with BLM protein levels. (2003) (47)
A comparison of globin genes in duck reticulocytes and liver cells. (1972) (46)
Tracing lymphopoiesis with the aid of a pTalpha-controlled reporter gene. (2002) (46)
Initiation and protein synthesis: translation of di- and tri-codon messengers. (1968) (46)
A variant limb deformity transcript expressed in the embryonic mouse limb defines a novel formin. (1992) (45)
Formin1 disruption confers oligodactylism and alters Bmp signaling. (2009) (44)
Transposon-generated ‘knock-out’ and ‘knock-in’ gene-targeting constructs for use in mice (1997) (44)
Allelic exclusion in transgenic mice carrying mutant human IgM genes (1988) (44)
Characterization of light chain and light chain constant region fragment mRNAs in MPC 11 mouse myeloma cells and variants (1975) (43)
Protein synthesis directed by encephalomyocarditis virus mRNA. 3. Discrete polypeptides translated from a monocistronic messenger in vitro. (1972) (43)
The oncogene heregulin induces apoptosis in breast epithelial cells and tumors (1998) (43)
RNA CODEWORDS AND PROTEIN SYNTHESIS, 3. ON THE NUCLEOTIDE SEQUENCE OF A CYSTEINE AND A LEUCINE RNA CODEWORD. (1964) (43)
Translation: its mechanism and control. (1972) (42)
A receptor binding domain of mouse interleukin-4 defined by a solid-phase binding assay and in vitro mutagenesis. (1992) (42)
The Role of a Single Formin Isoform in the Limb and Renal Phenotypes of Limb Deformity (1997) (42)
Bcl-2-mediated cell survival promotes metastasis of EpH4 betaMEKDD mammary epithelial cells. (2004) (39)
Genetic Evidence That Formins Function within the Nucleus* (1996) (38)
Nucleic acid and protein sequences of phosphocholine-binding light chains (1981) (38)
An Apoptosis-inducing Isoform of Neu Differentiation Factor (NDF) Identified Using a Novel Screen for Dominant, Apoptosis-inducing Genes (1997) (38)
High-affinity binding site for a specific nuclear protein in the human IgM gene (1985) (37)
Int-2, an autocrine and/or ultra-short-range effector in transgenic mammary tissue transplants. (1992) (36)
Immunoglobulin V/J recombination is accompanied by deletion of joining site and variable region segments. (1980) (36)
A Mouse Model for Breast Cancer Induced by Amplification and Overexpression of the neu Promoter and Transgene (2000) (36)
Detection of a frequent restriction fragment length polymorphism in the human T cell antigen receptor beta chain locus. A potential diagnostic tool. (1985) (35)
Transgenic expression of interleukin 7 restores T cell populations in nude mice (1995) (34)
Dispersion of alpha-like globin genes of the mouse to three different chromosomes. (1981) (34)
The mouse formin (Fmn) gene: genomic structure, novel exons, and genetic mapping. (1997) (34)
Protein synthesis directed by encephalomyocarditis virus RNA. II. The in vitro synthesis of high molecular weight proteins and elements of the viral capsid. (1971) (33)
Translation of Phage Qβ mRNA: A Test of the Two-site Model for Ribosomal Function (1970) (33)
Initiation of protein synthesis. 3. Factor-GTP-codon-dependent binding of F-met-tRNA to ribosomes. (1967) (33)
Translation of Bacteriophage Qβ Messenger RNA in a Murine Krebs 2 Ascites Tumor Cell-Free System (1972) (33)
Expression of c-MYC under the control of GATA-1 regulatory sequences causes erythroleukemia in transgenic mice (1995) (32)
Enzymatic synthesis of solid phase-bound DNA sequences corresponding to specific mammalian genes. (1974) (32)
The sequence of a mouse embryonic beta-globin gene. Evolution of the gene and its signal region. (1982) (32)
The regulation of c-myc by growth signals. (1984) (32)
The extracellular region of heregulin is sufficient to promote mammary gland proliferation and tumorigenesis but not apoptosis. (2000) (31)
Formins: phosphoprotein isoforms encoded by the mouse limb deformity locus. (1993) (31)
A mouse globin gene promoter is functional in SV40 (1980) (31)
Characterization, expression, and evolution of the mouse embryonic zeta-globin gene (1985) (31)
Mouse ζ- and α-Globin Genes: Embryonic Survival, α-Thalassemia, and Genetic Background Effects (1997) (30)
Genomic Instability Resulting from Blm Deficiency Compromises Development, Maintenance, and Function of the B Cell Lineage1 (2009) (30)
Protein biosynthesis in Escherichia coli. Purification and characteristics of a mutant G factor. (1970) (30)
The Bloom's Syndrome Helicase Is Critical for Development and Function of the αβ T-Cell Lineage (2007) (30)
Regulated expression of mammalian genes: globin and immunoglobulin as model systems. (1974) (30)
A RIBOSOME-CATALYZED REACTION BETWEEN N-FORMYLMETHIONYL-TRNA AND PUROMYCIN (1966) (29)
The organization and diversity of immunoglobulin genes. (1974) (29)
Translocation of mRNA codons. I. The preparation and characteristics of a homogeneous enzyme. (1969) (29)
RNA CODEWORDS AND PROTEIN SYNTHESIS, VI. ON THE NUCLEOTIDE SEQUENCES OF DEGENERATE CODEWORD SETS FOR ISOLEUCINE, TYROSINE, ASPARAGINE, AND LYSINE. (1965) (29)
Recombination events that activate, diversify, and delete immunoglobulin genes. (1981) (28)
SV40 T antigen transforms calcitonin cells of the thyroid but not CGRP-containing neurons in transgenic mice. (1991) (28)
Immunoglobulin light-chain structural gene sequences cloned in a bacterial plasmid (1978) (27)
High-affinity binding site for a specific nuclear protein in the human IgM gene (1985) (27)
Gene replacement with the human BRCA1 locus: tissue specific expression and rescue of embryonic lethality in mice (2000) (27)
The cloning of mouse globin and surrounding gene sequences in bacteriophage lambda. (1978) (27)
In vitro transcription of normal, mutant, and truncated mouse alpha-globin genes. (1980) (26)
Inactivation of p53 tumor suppressor gene acts synergistically with c-neu oncogene in salivary gland tumorigenesis (2001) (26)
The Sequence of the Chromosomal Mouse /3-Globin Major Gene: Homologies in Capping, Splicing and (1978) (25)
Identifying genes preferentially expressed in undifferentiated embryonic stem cells (2007) (24)
Characteristics of rabbit globin mRNA purification by oligo(dT) cellulose chromatography. (1974) (23)
Characterization of the initial peptide of Q-beta RNA polymerase and control of its synthesis. (1971) (22)
Neu Differentiation Factor (NDF), a Dominant Oncogene, Causes Apoptosis In Vitro and In Vivo (1998) (22)
Rescuing the in vitro function of a globin pseudogene promoter (1982) (22)
A Murine Homologue of the Drosophila brainiac Gene Shows Homology to Glycosyltransferases and Is Required for Preimplantation Development of the Mouse (2001) (22)
In vitro synthesis of DNA complementary to mRNA derived from a light chain-producing myeloma tumour. (1973) (20)
P53 levels determine outcome during β-catenin tumor initiation and metastasis in the mammary gland and male germ cells (2006) (20)
Variable amplification of immunoglobulin lambda light-chain genes in human populations. (1983) (20)
The gene for the rat mast cell high affinity IgE receptor alpha chain. Structure and alternative mRNA splicing patterns. (1989) (20)
DelBank: a mouse ES-cell resource for generating deletions (2001) (20)
Perinatal lethality (ple): a mutation caused by integration of a transgene into distal mouse chromosome 15. (1989) (19)
A variant translocation places the lambda immunoglobulin genes 3' to the c-myc oncogene in Burkitt's lymphoma. (1984) (19)
Biosynthesis of phage-specific initiation dipeptides. A purified biosynthetic system derived from Escherichia coli. (1971) (18)
neu protooncogene fused to an immunoglobulin heavy chain gene requires immunoglobulin light chain for cell surface expression and oncogenic transformation. (1988) (18)
Mouse Hus1, a homolog of the Schizosaccharomyces pombe hus1+ cell cycle checkpoint gene. (1999) (17)
Origin of immunoglobulin gene diversity: the evidence and a restriction-modification model. (1977) (16)
Initiation of protein synthesis,I. Effect of formylation of methionyl-tRNA on codon recognition. (1966) (16)
Translocation of mRNA codons. II. Properties of an anti-translocase antibody. (1969) (16)
An intervening sequence of the mouse β-globin major gene shares extensive homology only with β-globin genes (1978) (16)
The mast cell-specific expression of a protease gene, RMCP II, is regulated by an enhancer element that binds specifically to mast cell trans-acting factors. (1989) (15)
Purification and translation of an immunoglobulin lambda chain messenger RNA from mouse myeloma. (1976) (15)
Complete nucleotide sequence of the membrane form of the human IgM heavy chain. (1990) (15)
A human gene homologous to the formin gene residing at the murine limb deformity locus: chromosomal location and RFLPs. (1991) (15)
Genetic interaction between the unstable v-Ha-RAS transgene (Tg.AC) and the murine Werner syndrome gene: transgene instability and tumorigenesis (2002) (14)
The two site model of ribosomal function: a test using degenerate serine codons in bacteriophage f2 mRNA. (1970) (14)
Immunoglobulin γ1 heavy chain gene: Structural gene sequences cloned in a bacterial plasmid (1980) (13)
Polydactyly in the Strong's luxoid mouse is suppressed by limb deformity alleles. (1996) (13)
The same genomic region is disrupted in two transgene-induced limb deformity alleles (2004) (12)
Duplication and deletion in the human immunoglobulin epsilon genes. (1982) (12)
SV40 recombinants carrying rabbit beta-globin gene coding sequences. (1979) (12)
Mouse zeta- and alpha-globin genes: embryonic survival, alpha-thalassemia, and genetic background effects. (1997) (12)
The gene for the human mast cell high-affinity IgE receptor alpha chain: chromosomal localization to Iq21-q23 and RFLP analysis. (1989) (12)
Characterization of synthetic rabbit globin DNA. (1973) (12)
[156] An assay for the binding of aminoacyl-tRNA to ribosomes (1968) (11)
Molecular characterization of transgene-induced immunodeficiency in B- less mice using a novel quantitative limiting dilution polymerase chain reaction method (1993) (11)
A conserved sequence in the immunoglobulin J kappa-C kappa intron: possible enhancer element. (1983) (11)
Protein biosynthesis: studies using synthetic and viral mRNAs. (1969) (10)
Lymphohematopoietic and other malignant neoplasms occurring spontaneously in transgenic mice carrying and expressing MTV/myc fusion genes. (1986) (10)
Simple Paper Electrophoretic Method for detecting Macroglobulinæmia (1962) (10)
The protein tyrosine phosphatase epsilon gene maps to mouse chromosome 7 and human chromosome 10q26. (1996) (10)
The Bloom's syndrome helicase is critical for development and function of the alphabeta T-cell lineage. (2007) (9)
Structural analysis of both products of a reciprocal translocation between c-myc and immunoglobulin loci in Burkitt lymphoma. (1985) (9)
Can the human genome project be saved from its critics … and itself? (1990) (9)
A normal beta-globin allele as a modifier gene ameliorating the severity of alpha-thalassemia in mice. (1999) (9)
B-less: a strain of profoundly B cell-deficient mice expressing a human lambda transgene (1992) (9)
Translational initiation: defects arising in Escherichia coli infected with phage T7, , and Q . (1972) (9)
Homologous Genomic Fragments in the Mouse Pre-T Cell Receptor α (pTa) and Xist Loci ☆ (2000) (8)
Molecular mechanism for immunoglobulin double-isotype expression. (1989) (8)
Genetic control of immunoglobulin production. (1983) (8)
CELL-FREE PEPTIDE SYNTHESIS DEPENDENT UPON SYNTHETIC OLIGODEOXYNUCLEOTIDES. (1963) (8)
The effect of translocations on the cellular myc gene in burkitt lymphomas (1984) (7)
Regulation of initiation and elongation factor levels in Escherichia coli as assessed by a quantitative immunoassay. (1975) (7)
THE ORGANIZATION AND DIVERSITY OF IMMUNOGLOBULIN κ AND λ GENES (1975) (7)
Turnover of protein synthetic elongation and initiation factors in Escherichia coli. (1975) (7)
In vitro initiation of coliphage T7 mRNA. (1972) (7)
Mammary Morphogenesis and Oncogenes (1992) (6)
The organization and evolution of cloned globin genes. (1981) (5)
Structure and expression of a human subgroup II immunoglobulin x gene (1986) (5)
Summary In situ hybridization reveals co-expression of embryonic and adult globin genes in the earliest murine erythrocyte progenitors (1999) (5)
Human and rat mast cell high-affinity immunoglobulin E receptors : Characterization of putative a-chain gene products ( cDNA cloning / allergy ) (5)
Initiation of protein synthesis: the role of formyl-accepting methionyl-tRNA. (1966) (5)
RNA CODEWORDS AND PROTEIN SYNTHESIS, II. NUCLEOTIDE (2016) (5)
Expression of the chromosomal mouse Beta maj-globin gene cloned in SV40. (1979) (5)
Comparison ofcloned mousea-andj3-globin genes: Conservation ofintervening sequence locations andextragenic homology (1978) (5)
MEK 1 Signaling Mediates Transformation and Metastasis of EpH 4 Mammary Epithelial Cells Independent of an Epithelial to Mesenchymal Transition 1 (2002) (5)
A conserved role for the Hus1 checkpoint protein in eukaryotic genome maintenance. (2000) (4)
Parental legacy determines methylation and myocardial expression of an autosomal fusion gene carried by a transgenic mouse (1987) (4)
THE ARRANGEMENT, REARRANGEMENT AND ORIGIN OF IMMUNOGLOBULIN GENES (1979) (4)
Retinoic acid increases the sensitivity of the rat embryo fibroblast transformation assay (1988) (4)
Regulation of the humoral immune response: from immunoglobulin genes to regulatory T cell networks. (1983) (4)
In vitro transcription of normal , mutant , and truncated mouse a-globin genes ( promoters / RNA polymerase II / transcription initiation ) (4)
Unusual a-globin-like gene that has cleanly lost both globin intervening sequences ( gene conversion / recombinant DNA ) (3)
An intervening sequence of the mouse beta-globin major gene shares extensive homology only with beta-globin genes. (1978) (3)
Antibody diversity. (1978) (3)
The state of and prospects for molecular genetics in Burkitt's lymphoma. (1985) (3)
The organization and expression of cloned globin genes. (1980) (3)
Improved derivative of a phage lambda EK2 vector for cloning recombinant DNA. (1976) (3)
The Formins: Connecting Embryonic Pattern Formation and Hypofertility in the Mouse (2004) (3)
Scientific American introduction to molecular medicine (1994) (3)
Homologous genomic fragments in the mouse pre-T cell receptor alpha (pTa) and Xist loci. (2000) (3)
Close linkage of a transgene insertion site to the steel (Sl) locus on mouse chromosome 10. (1991) (3)
Marshall Warren Nirenberg (1927–2010) (2010) (3)
Globin genes: a paradigm of gene structure, function, and evolution. (1982) (2)
THE ORGANIZATION OF IMMUNOGLOBULIN GENES (1974) (2)
Cell Cycle Control of C-Myc Expression (1985) (2)
zeta-/- Thalassemic mice are affected by two modifying loci and display unanticipated somatic recombination leading to inherited variation. (2005) (2)
[165a] Enzymatic synthesis of trinucleoside diphosphates of known sequence (1968) (2)
Structure and Expression of the Human Immunoglobulin X Genes (2003) (2)
[31] Preparation of homogeneous Escherichia coli translocation factor G (1971) (2)
Chromatin structural changes in the putative regulatory region of c-myc accompany the translocation in a Burkitt lymphoma. (1984) (2)
The 1984 lynen lecture. A new genesis in genetics and medicine. Part II (1984) (2)
Correction: A Network of Conserved Damage Survival Pathways Revealed by a Genomic RNAi Screen (2009) (1)
Erratum: Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice (Genes and Development (1995) 9 (2712-2722)) (1996) (1)
A translocated humanc-myconcogene isaltered inaconserved coding sequence (1986) (1)
The sources of kappa light chain diversity: a review. (1980) (1)
Genome-wide SNP analysis of Tg.AC transgenic mice reveals an oncogenic collaboration between v-Ha-ras and Ink4a, which is absent in p53 deficiency (2008) (1)
MOVING GENES: PROMISES KEPT AND PENDING (1982) (1)
Purification andProperties ofBiologically Active Messenger RNA fora MyelomaLight Chain (1972) (1)
Matrix-Driven Translocation of Cells and Nonliving Particles (2005) (1)
A normal b-globin allele as a modifier gene ameliorating the severity of a-thalassemia in mice (1999) (1)
Chromatin structure of the human c-myc oncogene: definition of regulatory regions and changes in Burkitt's lymphomas. (1985) (1)
Immunoglobulin gamma 1 heavy chain gene: structural gene sequences cloned in a bacterial plasmid. (1980) (1)
Regulating Gene Expression in Mammalian Cell Culture and Transgenic Mice with Yeast GAL4/UAS Control Elements (1992) (1)
The Structure of the β-Globin Gene (1981) (1)
The 1984 Lynen Lecutre: A new genesis in genetics and medicine. Part I (1984) (1)
Mechanisms of gene evolution. (1982) (1)
B-less : a Strain of Profoundly B Cell-deficient Mice Expressing a Human ~ , Transgene By (2003) (0)
Erythropoiesis in the mouse begins with the production of a distinct population of red blood cells in the blood islands of the visceral yolk sac at day (1999) (0)
Table of Contents (1996) (0)
Characterization of Two Novel Oncogenic Pathways Collaborting With Loss of p53 or Activated Neu in Mouse Models of Breast Cancer (2004) (0)
Potential Function of the Werner’s Syndrome Homologue in the African Clawed Frog and the Mouse (2004) (0)
The Bloom’s Syndrome Helicase Is Critical for Development and Function of the (cid:2)(cid:3) T-Cell Lineage (cid:1) † (2007) (0)
Reduced Marcks-related protein expression promotes in vitro cell invasion and tumor desmoplasia (2008) (0)
United States Patent ( 19 ) Leder et al . ( 54 ) METHOD FOR PROVIDING ACELL CULTURE FROM A TRANSGENIC NON-HUMAN MAMMAL (2017) (0)
37 – Preparation of Homogeneous Escherichia coli Translocation Factor G (1981) (0)
United States Patent ( 19 ) Leder et al . ( 54 ) TRANSGENIC NON-HUMAN MAMMALS (2017) (0)
The Formation of Antibody Variable Region Genes (1983) (0)
Philip Leder in the Werner Syndrome Helicase Tumorigenic Effect of Nonfunctional p 53 or p 21 in Mice Mutant (2001) (0)
HUMAN IMMUNOGLOBULIN GENES: THE ONTOGENY OF SOMATIC REARRANGEMENTS (1981) (0)
Globin Messenger-RNA Induction During Erythroid Differentiation of Cultured Leukeiia Cells ( Friend leukemia virus / synthetic globin DNA / DNA-RNA hybridization ) (0)
The organization and evolution of cloned globin genes. (1980) (0)
Mutational analysis ofacritical signaling domainofthehuman interleukin 4receptor (1994) (0)
Translocation of the c-mnc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells ( recombination / chromosome / cancer / DNA ) (0)
An isoform specific disruption of the murine limb deformity locus distinguishes the renal and limb phenotypes (1994) (0)
Carcinogenesis in transgenic mouse models (2006) (0)
SETS FOR ISOLEUCINE, TYROSINE, ASPARAGINE, AND LYSINE (2016) (0)
RIPandFADD:Two"deathdomain"-containing proteins can induceapoptosis byconvergent, butdissociable, pathways (cell death/signal transduction/Fas/transfection) (1996) (0)
Transgenic Mice in the Study of Human Disease (1987) (0)
N-FORMYLMETHIONYL-TRNA AND PUROMYCIN (2016) (0)
Characterization, Expression, and Evolution of the Mouse Embryonic 4-Globin Gene (0)
Induction of globin mRNA in Friend leukemia virus-infected cells and its presence in viral 60S RNA. (1975) (0)
DNA complementary to globin and immunoglobulin mRNA: a probe to study gene expression. (1974) (0)
The RNA code: Nature’s Rosetta Stone (2014) (0)
The DNA dispute. Responses to Liebe F. Cavalieri's article "New strains of life--or death. (1976) (0)
Structure and expression of a human subgroup II immunoglobulin kappa gene. (1986) (0)
Gene Evolution v Special Creation-Reply (1983) (0)
Systeme genetique binaire commandant l'expression d'un gene mutant chez un animal a genes mutants (1991) (0)
Recombinant DNA technology: prologue and promise. (1979) (0)
Organization ofImmunoglobulin Genes: Reiteration Frequency oftheMouse KChainConstant RegionGene (1974) (0)
The Sequence of a Mouse Embryonic P-Globin Gene (2011) (0)
ADN CODANT L'alpha-SOUS-UNITE OU FRAGMENT DE CELLE-CI D'UN RECEPTEUR IgE (1988) (0)
Number : DAMD 17-021-0402 TITLE : Characterization of Two Novel Oncogenic Pathways Collaborating with Loss of p 53 or Activated Neu in Mouse Models of Breast Cancer (0)
Letter from Robert S. Adelstein, Christian B. Anfinsen, Julius Axelrod, Jack S. Cohen, Philip Leder, Maxine Singer, Bernhard Witkop, Earl R. Stadtman to Richard M. Nixon (1973) (0)
Loss of aim Radiosensitizes Multiple p53 Null Tissues1 (2006) (0)
Use of an EK-2 vector for the cloning of DNA from higher organisms. (1978) (0)
Process for creation of genetically engineered animals. (1985) (0)
RNA CODEWORDSAND PROTEINSYNTHESIS,VII. ON THE GENERALNATURE OF THE RNA CODE (1965) (0)
Composes regulant la proliferation et la differentiation cellulaires (2002) (0)
Identification of a cytoplasmic , phorbol ester-inducible isoform of protein tyrosine phosphatase E ( delayed early response / induction / differentiation ) (2005) (0)
An interview with... Philip Leder. Interview by Errol C. Friedberg. (2008) (0)
The structure of the beta-globin gene. (1981) (0)
362 Eotaxin is an eosinophil chemokine produced by endothelial and epithelial cells and during IL-4 tumor suppression (1996) (0)
Safer derivatives of bacteriophage lambdagt-lambdaC for use in cloning of recombinant DNA molecules. (1976) (0)
DNA CODING FOR IgE RECEPTOR SUBUNIT A or a fragment thereof (1988) (0)
For Evolutionary Psychiatrists, Psychologists and Others Interested in Sociophysiological Integration Course Readings Obscure Name (2011) (0)
neuprotooncogene fused toanimmunoglobulin heavychaingene requires immunoglobulin light chain forcell surface expression andoncogenic transformation (1988) (0)
The formin gene: A molecular link between apical extodermal ridge differentiation and anterior-posterior limb pattern formation (1989) (0)
The maturation of a pre-B cell to an immunoglobulin (Ig)-bearing B cell requires an effective recombination of a light chain variable (VL) (2003) (0)
Method for the detection of modified DNA (1984) (0)
IN VITRO AND IN VIVO TRANSCRIPTIONAL ANALYSIS OF MOUSE GLOBIN GENE PROMOTERS (1982) (0)

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