Philip A. Rea

Q: What Schools Are Affiliated With Philip A. Rea

Philip A. Rea is affiliated with the following schools: University of Pennsylvania, University of York, University of Sussex, University of California, San Diego

Philip A. Rea's AcademicInfluence.com Rankings

Philip A. Rea

Biology

#14363

World Rank

#18092

Historical Rank

Biochemistry

#2542

World Rank

#2707

Historical Rank

biology Degrees

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Biology

Why Is Philip A. Rea Influential?

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According to Wikipedia, Philip A. Rea is a British biochemist, science writer and educator, who is currently Professor of Biology and Rebecka and Arie Belldegrun Distinguished Director of the Vagelos Program in Life Sciences & Management at the University of Pennsylvania. His major contributions as a biochemist have been in the areas of membrane transport and xenobiotic detoxification, and as a science writer and educator in understanding the intersection between the life sciences and their implementation. In 2005, he and Mark V. Pauly founded the Roy and Diana Vagelos Program in Life Sciences & Management between the School of Arts and Sciences and Wharton School at the University of Pennsylvania, which he continues to co-direct in his capacity as Belldegrun Distinguished Director. Rea's work on serendipity in science has been featured in The Wall Street Journal. Additionally, he has served as a subject matter expert for 'The Scientist.

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Philip A. Rea's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Plant ABC proteins--a unified nomenclature and updated inventory. (2008) (627)
A new pathway for vacuolar cadmium sequestration in Saccharomyces cerevisiae: YCF1-catalyzed transport of bis(glutathionato)cadmium. (1997) (590)
Arsenic tolerance in Arabidopsis is mediated by two ABCC-type phytochelatin transporters (2010) (519)
The Arabidopsis thaliana ABC Protein Superfamily, a Complete Inventory* (2001) (485)
Plant ATP-binding cassette transporters. (2007) (467)
The Yeast Cadmium Factor Protein (YCF1) Is a Vacuolar Glutathione S-Conjugate Pump (*) (1996) (455)
AtPCS1, a phytochelatin synthase from Arabidopsis: isolation and in vitro reconstitution. (1999) (405)
Mechanism of Heavy Metal Ion Activation of Phytochelatin (PC) Synthase (2000) (383)
Tonoplast energization: Two H+ pumps, one membrane (1987) (324)
FROM VACUOLAR GS-X PUMPS TO MULTISPECIFIC ABC TRANSPORTERS. (1998) (316)
Transcriptome analysis of root transporters reveals participation of multiple gene families in the response to cation stress. (2003) (303)
AtMRP1 gene of Arabidopsis encodes a glutathione S-conjugate pump: isolation and functional definition of a plant ATP-binding cassette transporter gene. (1997) (286)
AtMRP2, an Arabidopsis ATP Binding Cassette Transporter Able to Transport Glutathione S-Conjugates and Chlorophyll Catabolites: Functional Comparisons with AtMRP1 (1998) (282)
Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport. (2001) (264)
CAX1, an H+/Ca2+ antiporter from Arabidopsis. (1996) (262)
Transport of amphipathic anions by human multidrug resistance protein 3. (2000) (240)
A New Pathway for Heavy Metal Detoxification in Animals (2001) (227)
Molecular cloning and sequence of cDNA encoding the pyrophosphate-energized vacuolar membrane proton pump of Arabidopsis thaliana. (1992) (186)
MRP subfamily ABC transporters from plants and yeast (1999) (180)
Vacuolar H(+) pyrophosphatases: from the evolutionary backwaters into the mainstream. (2001) (175)
MRP Subfamily Transporters and Resistance to Anticancer Agents (2001) (175)
Proton-Translocating Inorganic Pyrophosphatase in Red Beet (Beta vulgaris L.) Tonoplast Vesicles. (1985) (173)
The GS-X Pump in Plant, Yeast, and Animal Cells: Structure, Function, and Gene Expression (1997) (151)
Vacuolar H(+)-translocating pyrophosphatases: a new category of ion translocase. (1992) (150)
Enhanced Multispecificity of Arabidopsis Vacuolar Multidrug Resistance-associated Protein-type ATP-binding Cassette Transporter, AtMRP2* (2001) (132)
Weeds, Worms, and More. Papain's Long-Lost Cousin, Phytochelatin Synthase12 (2004) (131)
High purity preparations of higher plant vacuolar H+-ATPase reveal additional subunits. Revised subunit composition. (1989) (124)
Identification of 3-O-(4-benzoyl)benzoyladenosine 5'-triphosphate- and N,N'-dicyclohexylcarbodiimide-binding subunits of a higher plant H+-translocating tonoplast ATPase. (1985) (115)
Phytochelatin synthase, a dipeptidyltransferase that undergoes multisite acylation with gamma-glutamylcysteine during catalysis: stoichiometric and site-directed mutagenic analysis of arabidopsis thaliana PCS1-catalyzed phytochelatin synthesis. (2004) (112)
Heterologous expression of plant vacuolar pyrophosphatase in yeast demonstrates sufficiency of the substrate-binding subunit for proton transport. (1994) (111)
Voltage sensitivity of H+/Ca2+ antiport in higher plant tonoplast suggests a role in vacuolar calcium accumulation. (1990) (103)
Localization, Regulation, and Substrate Transport Properties of Bpt1p, a Saccharomyces cerevisiae MRP-Type ABC Transporter (2002) (98)
AVP2, a sequence-divergent, K(+)-insensitive H(+)-translocating inorganic pyrophosphatase from Arabidopsis. (2000) (98)
Acidic Residues Necessary for Pyrophosphate-energized Pumping and Inhibition of the Vacuolar H+-pyrophosphatase byN,N′-Dicyclohexylcarbodiimide* (1997) (95)
CeHMT-1, a Putative Phytochelatin Transporter, Is Required for Cadmium Tolerance in Caenorhabditis elegans* (2005) (94)
Phytochelatin synthase: of a protease a peptide polymerase made. (2012) (93)
Chromatographic resolution of h-translocating pyrophosphatase from h-translocating ATPase of higher plant tonoplast. (1986) (91)
Magnesium Adenosine 5[prime]-Triphosphate-Energized Transport of Glutathione-S-Conjugates by Plant Vacuolar Membrane Vesicles (1995) (89)
Plant gamma-glutamyl hydrolases and folate polyglutamates: characterization, compartmentation, and co-occurrence in vacuoles. (2005) (87)
The Molecular and Biochemical Basis of Pyrophosphate-Energized Proton Translocation at the Vacuolar Membrane (1997) (86)
Vacuolar uptake of the phytoalexin medicarpin by the glutathione conjugate pump. (1997) (83)
Presence of Host-Plasma Membrane Type H-ATPase in the Membrane Envelope Enclosing the Bacteroids in Soybean Root Nodules. (1985) (82)
The protein storage vacuole (2001) (82)
Two classes of plant-like vacuolar-type H(+)-pyrophosphatases in malaria parasites. (2001) (79)
Functional Characterization of AtATM1, AtATM2, and AtATM3, a Subfamily of Arabidopsis Half-molecule ATP-binding Cassette Transporters Implicated in Iron Homeostasis* (2007) (79)
Potassium transport into plant vacuoles energized directly by a proton-pumping inorganic pyrophosphatase. (1992) (78)
Alternate Energy-Dependent Pathways for the Vacuolar Uptake of Glucose and Glutathione Conjugates1 (2002) (77)
Site-directed Mutagenesis of Vacuolar H+-pyrophosphatase (1995) (77)
A thermostable vacuolar‐type membrane pyrophosphatase from the archaeon Pyrobaculum aerophilum: implications for the origins of pyrophosphate‐energized pumps (1999) (76)
Isolation and Characterization of cDNAs Encoding the Vacuolar H+-Pyrophosphatase of Beta vulgaris (1994) (72)
Aminomethylenediphosphonate: A Potent Type-Specific Inhibitor of Both Plant and Phototrophic Bacterial H+-Pyrophosphatases (1994) (70)
Mutagenic Definition of a Papain-Like Catalytic Triad, Sufficiency of the N-Terminal Domain for Single-Site Core Catalytic Enzyme Acylation, and C-Terminal Domain for Augmentative Metal Activation of a Eukaryotic Phytochelatin Synthase1 (2006) (68)
AtMRP 2 , an Arabidopsis ATP Binding Cassette Transporter Able to Transport Glutathione S-Conjugates and Chlorophyll Catabolites : Functional Comparisons with AtMRP 1 (1998) (67)
1-Chloro-2,4-Dinitrobenzene-Elicited Increase in Vacuolar Glutathione-S-Conjugate Transport Activity (1995) (66)
Identification and purification of substrate‐binding subunit of higher plant H+‐translocating inorganic pyrophosphatase (1989) (66)
Drosophila ABC Transporter, DmHMT-1, Confers Tolerance to Cadmium (2009) (65)
Steady-state kinetics of substrate hydrolysis by vacuolar H+-pyrophosphatase (1993) (64)
Common identity of substrate binding subunit of vacuolar h-translocating inorganic pyrophosphatase of higher plant cells. (1992) (63)
Plant Vacuolar ATP-binding Cassette Transporters That Translocate Folates and Antifolates in Vitro and Contribute to Antifolate Tolerance in Vivo* (2009) (57)
Non-invasive optical methods for the study of cerebral metabolism in the human newborn: a technique for the future? (1985) (57)
Irreversible inhibition of H+-ATPase of higher plant tonoplast by chaotropic anions: evidence for peripheral location of nucleotide-binding subunits (1987) (57)
Localization of cytosolically oriented maleimide-reactive domain of vacuolar H(+)-pyrophosphatase. (1994) (56)
Differential sensitivity of membrane‐associated pyrophosphatases to inhibition by diphosphonates and fluoride delineates two classes of enzyme (1993) (53)
Isolation and characterization of TgVP1, a type I vacuolar H+-translocating pyrophosphatase from Toxoplasma gondii. The dynamics of its subcellular localization and the cellular effects of a diphosphonate inhibitor. (2003) (52)
Vacuolar proton‐pumping pyrophosphatase inBeta vulgaris shows vectorial activation by potassium (1991) (50)
The protein storage vacuole: a unique compound organelle (2001) (49)
Worms take the 'phyto' out of 'phytochelatins'. (2002) (48)
Phytochelatin Synthase, a Dipeptidyltransferase That Undergoes Multisite Acylation with γ-Glutamylcysteine during Catalysis (2004) (45)
Analysis of the vacuolar luminal proteome of Saccharomyces cerevisiae (2007) (45)
Mechanism of Stimulation and Inhibition of Tonoplast H-ATPase of Beta vulgaris by Chloride and Nitrate. (1986) (42)
Regulation of vacuolar h-pyrophosphatase by free calcium : a reaction kinetic analysis. (1992) (42)
Reconstitution of transport function of vacuolar H(+)-translocating inorganic pyrophosphatase. (1992) (36)
Phytochelatin synthase, papain's cousin, in stereo. (2006) (31)
[12] Preparation of tonoplast vesicles: Applications to H+-coupled secondary transport in plant vacuoles (1987) (28)
Do plants have more genes than humans? Yes, when it comes to ABC proteins. (2001) (27)
Tonoplast Adenosine Triphosphatase and Inorganic Pyrophosphatase (1990) (27)
The dynamics of H+ efflux from the trap lobes of Dionaea muscipula Ellis (Venus's flytrap) (1983) (25)
Purification of the N,N'-dicyclohexylcarbodiimide-binding proteolipid of a higher plant tonoplast H+-ATPase. (1987) (23)
Adaptive Engineering of Phytochelatin-based Heavy Metal Tolerance* (2015) (23)
Quantitative and rapid estimation of h fluxes in membrane vesicles : software for analysis of fluorescence quenching and relaxation. (1988) (21)
Steady-state kinetics of substrate hydrolysis by vacuolar H(+)-pyrophosphatase. A simple three-state model. (1993) (21)
Recording and identification of single motor units in the free-to-move primate hand (2004) (19)
Fluid Composition and Factors that Elicit Secretion by the Trap Lobes of Dionaea muscipula Ellis (1982) (17)
Ion genomics (2003) (13)
Plant γ-Glutamyl Hydrolases and Folate Polyglutamates (2005) (13)
Oxygen exchange reactions catalyzed by vacuolar H+‐translocating pyrophosphatase Evidence for reversible formation of enzyme‐bound pyrophosphate (1994) (12)
SECRETION AND REDISTRIBUTION OF CHLORIDE IN THE DIGESTIVE GLANDS OF DIONAEAMUSCIPULA ELLIS (VENUS'S FLYTRAP) UPON SECRETION STIMULATION (1983) (11)
CHAPTER 17 – THE PLANT ABC TRANSPORTER SUPERFAMILY: THE FUNCTIONS OF A FEW AND IDENTITIES OF MANY (2003) (11)
Evidence for the H+‐co‐transport of d‐alanine by the digestive glands of Dionaea muscipula Ellis (1984) (11)
The GSX Pump in Plant , Yeast , and Animal Cells : Structure , Function , and Gene Expression (2003) (10)
The cuticle ofDionaea muscipula ellis (Venus's Flytrap) in relation to stimulation, secretion and absorption (1983) (9)
Vacuolar Transport of Secondary Metabolites and Xenobiotics (2018) (7)
The influence of secretion elicitors and external pH on the kinetics of D-alanine uptake by the trap lobes of Dionaea muscipula Ellis (Venus's Flytrap) (1983) (7)
Proton-Translocating Inorganic Pyrophosphatase inRedBeet (1985) (6)
Ivermectin and River Blindness: Science and philanthropy put an end to blindly following the next generation (2010) (6)
Resistance Protein 3 Transport of Amphipathic Anions by Human Multidrug Updated (2000) (6)
Assessment and optimisation of dip-coating procedure for the preparation of electroenzymic glucose transducers (1985) (6)
A farewell to bacterial ARMs? (2005) (6)
Plant Organelles Compartmentation of Metabolism in Photosynthetic Cells: Transport of H+, K+ and Ca2+ at the vacuolar membrane of plants (1992) (5)
Towards non-invasive monitoring of cerebral metabolism (1986) (4)
Phytochelatin Synthase (2020) (4)
Physician Impact Analysis: An Imperative for the Modern Hospital (1988) (4)
AVP 2 , a Sequence-Divergent , K 1-Insensitive H 1-Translocating Inorganic Pyrophosphatase from Arabidopsis 1 (2000) (3)
Metformin: Out of Backwaters and into the Mainstream (2017) (2)
The influence of secretion elicitors and other effectors of H+ efflux on carboxylate synthesis by the trap lobes of Dionaea muscipula ellis (venus's flytrap) (1983) (2)
Retinopathy of prematurity, intraventricular hemorrhage, and oxidative damage. (1986) (2)
Statins: From Fungus to Pharma : The curiosity of biochemists, mixed with some obvious economic incentives, created a family of powerful cardiovascular drugs (2008) (2)
Vacuolar H + -translocating Inorganic Pyrophosphatase: Biochemistry and Molecular Biology (1992) (2)
Isolation and Characterization of TgVP1, a Type I Vacuolar H+-translocating Pyrophosphatase fromToxoplasma gondii (2003) (2)
Wash-activated Na+/H+ exchange in tonoplast vesicles from Beta vulgaris storage root disks (1987) (2)
Managing Discovery in the Life Sciences: Harnessing Creativity to Drive Biomedical Innovation (2018) (2)
Detoxification of xenobiotics revisited (1997) (1)
Electrochemical transducers for the measurement of biological compounds. (1984) (1)
A Third-Category and a Fourth-Category H+-Phosphohydrolase at the Tonoplast (1987) (1)
A Microcomputer-Based System for the Recording and Analysis of Fluorescence Transients from Membrane Vesicles (1987) (0)
Molecular Dissection of Vacuolar H+-Pyrophosphatase (1994) (0)
Mechanism of Stimulation and Inhibition of Tonoplast (0)
Chromatographic Resolution ofH -Translocating Pyrophosphatase fromH -Translocating ATPaseofHigher Plant Tonoplast' (1986) (0)
Complete inventory of Arabidopsis ABC proteins (2001) (0)
Managing Discovery in the Life Sciences (2018) (0)
Can Skinny Fat Beat Obesity (2014) (0)
Isolation and Characterization of cDNAs Encoding the Vacuolar H +-Pyrophosphatase of Beta vulgaris ' (2002) (0)
Evidence for the Widespread Distribution of Membrane-Bound Inorganic Pyrophosphatasfs among Photosyntheiic Prokaryotes (1998) (0)
Mechanism ofStimulation andInhibition ofTonoplast H+-ATPase ofBetavulgaris byChloride andNitratel (1986) (0)
Yeast DNP-GS transporter is encoded by YCF1 (1995) (0)
Economy, costs and funding: key issues for Canada's health care system. (1992) (0)
Can Government Help with the Creatively Unexpected (2018) (0)
Differential Susceptibilities of Tonoplast ATPase and PPase to Irreversible Inhibition by Chaotropic Anions (1987) (0)
Update on Phytochelatin Synthase (2004) (0)

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