Philipp Holliger
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Swiss molecular biologist
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Philipp Holligerbiology Degrees
Biology
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Evolutionary Biology
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Molecular Biology
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Biology
Philipp Holliger's Degrees
- PhD Chemistry University of Zurich
Why Is Philipp Holliger Influential?
(Suggest an Edit or Addition)According to Wikipedia, Philipp Holliger is a Swiss molecular biologist best known for his work on xeno nucleic acids and RNA engineering. Holliger is a program leader at the MRC Laboratory of Molecular Biology . Background He earned his degree in Natural Sciences from ETH Zürich, Switzerland, where he worked with Steven Benner, and his Ph.D. in Molecular Biology at the MRC Centre for Protein Engineering in Cambridge under the mentorship of Sir Gregory Winter and Tim Richmond .
Philipp Holliger's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Engineered antibody fragments and the rise of single domains (2005) (1761)
- "Diabodies": small bivalent and bispecific antibody fragments. (1993) (872)
- Synthetic Genetic Polymers Capable of Heredity and Evolution (2012) (557)
- Directed evolution of polymerase function by compartmentalized self-replication (2001) (364)
- Ribozyme-Catalyzed Transcription of an Active Ribozyme (2011) (331)
- Mimicking somatic hypermutation: affinity maturation of antibodies displayed on bacteriophage using a bacterial mutator strain. (1996) (236)
- In-ice evolution of RNA polymerase ribozyme activity. (2013) (205)
- The C-Terminal Domain of TolA Is the Coreceptor for Filamentous Phage Infection of E. coli (1997) (196)
- Crystal structure of a diabody, a bivalent antibody fragment. (1994) (196)
- Catalysts from synthetic genetic polymers (2014) (195)
- Natural fission reactors in the Franceville basin, Gabon: A review of the conditions and results of a “critical event” in a geologic system (1996) (187)
- Generic expansion of the substrate spectrum of a DNA polymerase by directed evolution (2004) (166)
- Lead cycling in estuaries, illustrated by the Gironde estuary, France (1984) (165)
- The XNA world: progress towards replication and evolution of synthetic genetic polymers. (2012) (157)
- Ice as a protocellular medium for RNA replication. (2010) (126)
- Molecular breeding of polymerases for amplification of ancient DNA (2007) (122)
- Specific killing of lymphoma cells by cytotoxic T-cells mediated by a bispecific diabody. (1996) (115)
- Towards XNA nanotechnology: new materials from synthetic genetic polymers (2014) (105)
- Freeze-thaw cycles as drivers of complex ribozyme assembly. (2015) (101)
- Improved tumour targeting by disulphide stabilized diabodies expressed in Pichia pastoris. (1997) (100)
- Interface and material characterization of thin Al2O3 layers deposited by ALD using TMA/H2O (2002) (99)
- Stable lead isotopes ratios in major french rivers and estuaries (1986) (95)
- A short adaptive path from DNA to RNA polymerases (2012) (95)
- Organic matter and containment of uranium and fissiogenic isotopes at the Oklo natural reactors (1991) (91)
- Directed evolution of DNA polymerase, RNA polymerase and reverse transcriptase activity in a single polypeptide. (2006) (91)
- CyDNA: Synthesis and Replication of Highly Cy-Dye Substituted DNA by an Evolved Polymerase (2010) (90)
- Selection of 2′-deoxy-2′-fluoroarabinonucleotide (FANA) aptamers that bind HIV-1 reverse transcriptase with picomolar affinity (2015) (90)
- Crystal structure of the two N-terminal domains of g3p from filamentous phage fd at 1.9 A: evidence for conformational lability. (1999) (87)
- Carcinoembryonic antigen (CEA)-specific T-cell activation in colon carcinoma induced by anti-CD3 x anti-CEA bispecific diabodies and B7 x anti-CEA bispecific fusion proteins. (1999) (85)
- The 2.0-A resolution crystal structure of a trimeric antibody fragment with noncognate VH-VL domain pairs shows a rearrangement of VH CDR3. (1997) (83)
- Retargeting serum immunoglobulin with bispecific diabodies (1997) (80)
- Engineering bispecific antibodies. (1993) (76)
- A conserved infection pathway for filamentous bacteriophages is suggested by the structure of the membrane penetration domain of the minor coat protein g3p from phage fd. (1997) (74)
- Ribozyme-catalysed RNA synthesis using triplet building blocks (2018) (73)
- Polymerase engineering: towards the encoded synthesis of unnatural biopolymers. (2009) (71)
- Metallogenesis of the French part of the Variscan orogen. Part II: Time-space relationships between U, Au and SnW ore deposition and geodynamic events — mineralogical and UPb data (1990) (66)
- Molecular breeding of polymerases for resistance to environmental inhibitors (2011) (65)
- Evolving a polymerase for hydrophobic base analogues. (2009) (65)
- Inhibition of tumor growth in vivo by in situ secretion of bispecific anti-CEA × anti-CD3 diabodies from lentivirally transduced human lymphocytes (2007) (61)
- Geochemical and Neutronic Characteristics of the Natural Fossil Fission Reactors at Oklo and Bangombé, Gabon (1998) (61)
- The role of ultraviolet radiation during ultralow k films curing: Strengthening mechanisms and sacrificial porogen removal (2007) (60)
- Interface properties of ultra-thin HfO2 films grown by atomic layer deposition on SiO2/Si (2003) (60)
- Role of organic matter in the Proterozoic Oklo natural fission reactors, Gabon, Africa (1993) (56)
- Lanthanide tetrad effect observed in the Oklo and ordinary uraninites and its implication for their forming processes (1992) (55)
- A synthetic genetic polymer with an uncharged backbone chemistry based on alkyl phosphonate nucleic acids (2019) (50)
- Simple peptides derived from the ribosomal core potentiate RNA polymerase ribozyme function. (2017) (49)
- Exploring the Chemistry of Genetic Information Storage and Propagation through Polymerase Engineering (2017) (48)
- Non-destructive X-ray study of the interphases in Mo/Si and Mo/B4C/Si/B4C multilayers (2006) (48)
- Diabodies: small bispecific antibody fragments (1997) (47)
- Nucleic acids: function and potential for abiogenesis (2017) (46)
- A novel emulsion mixture for in vitro compartmentalization of transcription and translation in the rabbit reticulocyte system. (2004) (46)
- Occurrence of naturally enriched 235U: Implications for plutonium behaviour in natural environments (1993) (44)
- Mineralogical, chemical and isotopic (U-Pb method) studies of Hercynian uraniferous mineralizations (Margnac and Fanay mines, Limousin, France) (1984) (44)
- Antibodies come back from the brink (1998) (43)
- Nanostructures from Synthetic Genetic Polymers (2016) (43)
- Directed evolution of artificial enzymes (XNAzymes) from diverse repertoires of synthetic genetic polymers (2015) (42)
- Towards applications of synthetic genetic polymers in diagnosis and therapy. (2014) (41)
- Modification of GaN(0001) growth kinetics by Mg doping (2004) (40)
- Modified nucleic acids: replication, evolution, and next-generation therapeutics (2020) (36)
- Structural properties of undoped and doped cubic GaN grown on SiC(001) (2002) (36)
- Site‐directed mutagenesis of bovine pancreatic ribonuclease: Lysine‐41 and aspartate‐121 (1991) (35)
- Low-temperature RPCVD of Si, SiGe alloy, and Si1−yCy films on Si substrates using trisilane (Silcore®) (2009) (34)
- Isolation of receptor–ligand pairs by capture of long-lived multivalent interaction complexes (2002) (33)
- Evidence of fissiogenic Cs estimated from Ba isotopic deviations in an Oklo natural reactor zone (1993) (33)
- Synthetic polymers and their potential as genetic materials (2013) (33)
- Engineering and application of polymerases for synthetic genetics. (2017) (31)
- Subunit disassembly and inhibition of TNFα by a semi-synthetic bicyclic peptide (2015) (30)
- Beyond DNA and RNA: The Expanding Toolbox of Synthetic Genetics. (2019) (30)
- A synthetic approach to abiogenesis (2014) (30)
- Non-Enzymatic Assembly of a Minimized RNA Polymerase Ribozyme (2019) (29)
- Structures of an Apo and a Binary Complex of an Evolved Archeal B Family DNA Polymerase Capable of Synthesising Highly Cy-Dye Labelled DNA (2013) (29)
- Chemical fidelity of an RNA polymerase ribozyme (2013) (28)
- Petrography and paragenesis of organic matter associated with the natural fission reactors at Oklo, Republic of Gabon: a preliminary report (1993) (27)
- Selection of 2′-Deoxy-2′-Fluoroarabino Nucleic Acid (FANA) Aptamers That Bind HIV-1 Integrase with Picomolar Affinity (2019) (27)
- Random-sequence genetic oligomer pools display an innate potential for ligation and recombination (2018) (27)
- Discovery and evolution of RNA and XNA reverse transcriptase function and fidelity (2020) (27)
- Darwinian chemistry: towards the synthesis of a simple cell. (2009) (27)
- Methods for generating multivalent and bispecific antibody fragments. (2000) (26)
- Characterization of a La-Ce-Sr-Ca aluminous hydroxy phosphate in nuclear zone 13 in the Oklo uranium deposit (Gabon) (1997) (26)
- Isoguanine and 5-Methyl-Isocytosine Bases, In Vitro and In Vivo (2015) (25)
- Isotopic evidence for the retention of90Sr inferred from excess90Zr in the Oklo natural fission reactors: Implication for geochemical behaviour of fissiogenic Rb, Sr, Cs and Ba (1994) (24)
- Diffusion processes in NiTi/Si, NiTi/SiO2 and NiTi/Si3N4 systems under annealing (2004) (24)
- A model for238U radioactive daughter loss from sediment-hosted pitchblende deposits and the Late permian-early triassic depositional U-Pb age of the Müllenbach uranium ore (Baden-Württemberg, F.R.G.) (1989) (22)
- Engineering high affinity superantigens by phage display. (2005) (22)
- Engineering Antibodies for the Clinic (2004) (21)
- Compartmentalized Self‐Tagging for In Vitro‐Directed Evolution of XNA Polymerases (2014) (21)
- Non-canonical 3′-5′ Extension of RNA with Prebiotically Plausible Ribonucleoside 2′,3′-Cyclic Phosphates (2014) (21)
- Polytype transition of N-face GaN:Mg from wurtzite to zinc-blende (2004) (20)
- Geochemical Behaviour of 99Tc in the Oklo Natural Fission Reactors (1993) (20)
- Origins of life: The cooperative gene (2012) (19)
- Enzymatic Synthesis of Nucleic Acids with Defined Regioisomeric 2′‐5′ Linkages (2015) (19)
- Artificial antibodies and enzymes: mimicking nature and beyond. (1995) (19)
- Tc/Ru fractionation in the Oklo and Bangombé natural fission reactors, Gabon (1999) (18)
- CD3× anti‐nitrophenyl bispecific diabodies: Universal immunotherapeutic tools for retargeting T cells to tumors (1999) (16)
- Crystal Structure of the Two N-terminal Domains of g3p from Filamentous Phage fd at 1.9 A ˚ : Evidence for (1999) (16)
- Compartmentalized Self-Replication (2007) (16)
- Compartmentalized self-replication: a novel method for the directed evolution of polymerases and other enzymes. (2007) (16)
- Growth and Characterization of Thick GaAsN Epilayers and GaInNAs/GaAs Multiquantum Wells (1999) (16)
- Selecting Fully‐Modified XNA Aptamers Using Synthetic Genetics (2018) (13)
- On the influence of elastic strain on the accommodation of carbon atoms into substitutional sites in strained Si:C layers grown on Si substrates (2009) (12)
- In situ U-Pb age determination by secondary ion mass spectrometry (1988) (12)
- Autocrine costimulation: Tumor-specific CD28-mediated costimulation of T cells by in situ production of a bifunctional B7–anti-CEA diabody fusion protein (2002) (12)
- Reversible Fluorescence Photoswitching in DNA (2012) (12)
- Direct Mapping of Higher-Order RNA Interactions by SHAPE-JuMP. (2021) (11)
- Measurement of the redistribution of arsenic at nickel silicide/silicon interface by secondary ion mass spectrometry: artifact and optimized analysis conditions (2008) (11)
- Redistribution of arsenic during the reaction of nickel thin films with silicon at relatively high temperature: Role of agglomeration (2006) (11)
- Analysis of a B4C/Mo/Si multilayer interferential mirror by SIMS: influence of the sputtering ion (2006) (10)
- Rolling circle RNA synthesis catalyzed by RNA (2022) (10)
- Crystallisation kinetics and density profiles in ultra-thin hafnia films (2004) (9)
- Chemical biotechnology--a marriage of convenience and necessity. (2010) (9)
- A polymerase engineered for bisulfite sequencing (2015) (8)
- Effect of a Hydrogen Bonding Carboxamide Group on Universal Bases (2006) (8)
- Polymerase engineering: from PCR and sequencing to synthetic biology (2012) (8)
- Migration of Fission Products into Micro-Minerals of the Oklo Natural Reactors (1994) (8)
- New chemistries and enzymes for synthetic genetics (2022) (8)
- Fabrication of SiGe-On-Insulator by Improved Ge Condensation Technique (2006) (7)
- A two-residue nascent-strand steric gate controls synthesis of 2′-O-methyl- and 2′-O-(2-methoxyethyl)-RNA (2022) (7)
- From diffusion processes to adherence properties in NiTi microactuators (2003) (7)
- Physico‐chemical study of the interfaces of Mo/Si multilayer interferential mirrors: correlation with the optical properties (2006) (7)
- Migration of Fission Products into Micro-Minerals of the Oklo Natural Reactors (1994) (6)
- Translesion synthesis across the (6-4) photoproduct and its Dewar valence isomer by the Y-family and engineered DNA polymerases. (2008) (6)
- Extended X-Ray Absorption Fine Structure Study of Arsenic in HgCdTe (2007) (6)
- Spectroscopic studies of TM/Si and TM/SiO2 interfaces (2003) (5)
- Innate potential of random genetic oligomer pools for recombination (2018) (5)
- Study of surface modification of uranium and UFe2 by various surface analysis techniques (2001) (5)
- A modular XNAzyme cleaves long, structured RNAs under physiological conditions and enables allele-specific gene silencing (2022) (5)
- Expression of antibody fragments in Pichia pastoris. (2002) (4)
- Structural Studies of HNA Substrate Specificity in Mutants of an Archaeal DNA Polymerase Obtained by Directed Evolution (2020) (4)
- Rolling Circle RNA Synthesis Catalysed by RNA (2021) (4)
- Phase transition by Mg doping of N-face polarity GaN (2005) (4)
- Process damages in HfO/sub 2//TiN stacks: the key role of H/sup 0/ and H/sub 2/ anneals (2005) (4)
- On gene silencing by the X10-23 DNAzyme (2022) (4)
- Polymerase Engineering: Towards the Encoded Synthesis of Unnatural Biopolymers (2009) (4)
- Efficient synthesis and replication of diverse sequence libraries composed of biostable nucleic acid analogues (2022) (3)
- Hydrophobic-cationic peptides modulate RNA polymerase ribozyme activity by accretion (2022) (3)
- Faculty Opinions recommendation of Self-assembled RNA interference microsponges for efficient siRNA delivery. (2012) (3)
- Modified nucleic acids: replication, evolution, and next-generation therapeutics (2020) (2)
- Material for Ribozyme-Catalyzed Transcription of an Active Ribozyme (2011) (2)
- Faculty Opinions recommendation of Comprehensive experimental fitness landscape and evolutionary network for small RNA. (2013) (2)
- RNA Replication and the RNA Polymerase Ribozyme (2021) (2)
- Hydrophobic-cationic peptides enhance RNA polymerase ribozyme activity by accretion (2021) (2)
- Enzymatic Synthesis of Nucleic Acids with Defined Regioisomeric 2′‐5′ Linkages. (2016) (1)
- Phage-display library selection and mutation for the engineering of antibody affinity (1996) (1)
- Antibodies live long and prosper (1997) (1)
- Modifications of post - implantation defects and their activity by annealing procedure (2000) (1)
- Thermal effects on 1H and 2H distributions determined by SIMS in atomic layer deposition of HfO2 and Al2O3 using heavy water (2006) (1)
- Modeling dopant diffusion in SiGe and SiGeC layers (2004) (1)
- Carcinoembryonic Antigen ( CEA )-specific T-Cell Activation in Colon Carcinoma Induced by Anti-CD 3 3 Anti-CEA Bispecific Diabodies and B 7 3 Anti-CEA Bispecific Fusion Proteins 1 (1999) (1)
- Tumour targeting using MFE-23::TNF alpha fusion protein. (1999) (1)
- Uranium mineralizations in western europe: The witness of major geodynamic events from devonian to tertiary (1988) (1)
- Emergence of function from single RNA sequences by Darwinian evolution (2021) (1)
- Determination of strain within Si1-yCy layers grown by CVD on a Si substrate (2007) (0)
- Author response: Ribozyme-catalysed RNA synthesis using triplet building blocks (2018) (0)
- Simple Non-Coded Peptides Enhance RNA Polymerase Ribozyme Function (2017) (0)
- Title : Random-sequence genetic oligomer pools display an innate potential 1 for ligation and recombination (0)
- Faculty Opinions recommendation of Mapping a Systematic Ribozyme Fitness Landscape Reveals a Frustrated Evolutionary Network for Self-Aminoacylating RNA. (2019) (0)
- Critical Analysis of Different Techniques for Measuring Strain in Si1-yCy Layers Grown by CVD on a Si Substrate (2008) (0)
- Method for targeted evolution (2001) (0)
- U NDERSTANDING AND TARGETING P ROTEIN-RNA INTERACTIONS WITHIN THE Ψ-P ACKAGING DOMAIN OF HIV-1 (2012) (0)
- Faculty Opinions recommendation of Darwinian evolution in a translation-coupled RNA replication system within a cell-like compartment. (2014) (0)
- Structural and electrical properties of CVD-WNx thin films deposited on high-k materials (2006) (0)
- Faculty Opinions recommendation of Abiotic synthesis of purine and pyrimidine ribonucleosides in aqueous microdroplets. (2018) (0)
- "Diabodies": Smallbivalent andbispecific antibody fragments (1993) (0)
- 12 Reconstructing the RNA world (2013) (0)
- Faculty Opinions recommendation of Synthesis of phosphoramidate-linked DNA by a modified DNA polymerase. (2020) (0)
- In Search for Alternative Genetic Material (2019) (0)
- F diffusion processes to adherence properties in NiTi (2003) (0)
- Introduction to the themed collection on XNA xeno-nucleic acids (2022) (0)
- Self‐Replication in Chemistry and Biology (2009) (0)
- Cryo-EM structure and functional landscape of an RNA polymerase ribozyme (2022) (0)
- TgoT_6G12 Binary complex (2020) (0)
- Procede d'evolution dirigee (2001) (0)
- Faculty Opinions recommendation of Synthetic shuffling and in vitro selection reveal the rugged adaptive fitness landscape of a kinase ribozyme. (2013) (0)
- Explorer Reversible Fluorescence Photoswitching in DNA (2012) (0)
- Search for long-lived isotopes at the K-T boundary: A test for the existence of interstellar comets (1988) (0)
- TgoT_6G12 binary with 2 hCTPs (2020) (0)
- Crystal Structure of an Evolved Replicating DNA Polymerase (2012) (0)
- STRUCTURE OF THE N-TERMINAL TWO DOMAINS OF THE INFECTIVITY PROTEIN G3P OF FILAMENTOUS PHAGE FD (1999) (0)
- ESI Chemical fidelity of an RNA polymerase ribozyme c3sc50574j (2013) (0)
- Multivalent and bispecific antibody fragments from E.coli (1994) (0)
- Faculty of 1000 evaluation for Crystal structures of ternary complexes of archaeal B-family DNA polymerases. (2018) (0)
- TgoT_6G12 Ternary complex (2021) (0)
- Human TNFa dimer in complex with the semi-synthetic bicyclic peptide M21 (2015) (0)
- Effect of fluorinated plasma on SiLK during mineral hard masks etching (2000) (0)
- DNA polymerases for incorporation of the dye-labeled nucleotide analogs (2007) (0)
- Author response: Random-sequence genetic oligomer pools display an innate potential for ligation and recombination (2018) (0)
- Trinucleotide building blocks enable exponential ribozyme-catalysed RNA replication and open-ended growth of diverse RNA sequence pools (2023) (0)
- In-ice evolution of RNApolymerase ribozyme activity (2013) (0)
- MEMBRANE PENETRATION DOMAIN OF THE MINOR COAT PROTEIN G3P OF PHAGE FD, NMR, 15 STRUCTURES (1997) (0)
- Method for enrichment of nucleic acid molecules (2002) (0)
- A method for directed evolution (2001) (0)
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What Schools Are Affiliated With Philipp Holliger?
Philipp Holliger is affiliated with the following schools:
