Philippe Christen
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Computer Science
Philippe Christen's Degrees
- PhD Computer Science University of Geneva
- Masters Computer Science University of Geneva
- Bachelors Computer Science University of Geneva
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(Suggest an Edit or Addition)Philippe Christen's Published Works
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Published Works
- Recent extraction techniques for natural products: microwave-assisted extraction and pressurised solvent extraction. (2002) (669)
- Kinetics of molecular chaperone action. (1994) (444)
- Mechanism of action of aspartate aminotransferase proposed on the basis of its spatial structure. (1984) (390)
- Aminotransferases: demonstration of homology and division into evolutionary subgroups. (1993) (387)
- Evolutionary relationships among pyridoxal‐5′‐phosphate‐dependent enzymes (1994) (315)
- Heavy Metals and Metalloids As a Cause for Protein Misfolding and Aggregation (2014) (289)
- The molecular evolution of pyridoxal-5'-phosphate-dependent enzymes. (2000) (243)
- Multiple evolutionary origin of pyridoxal-5'-phosphate-dependent amino acid decarboxylases. (1994) (225)
- Demonstration of the ethylmalonyl-CoA pathway by using 13C metabolomics (2009) (219)
- The kinetic parameters and energy cost of the Hsp70 chaperone as a polypeptide unfoldase. (2010) (211)
- From cofactor to enzymes. The molecular evolution of pyridoxal-5'-phosphate-dependent enzymes. (2001) (187)
- Heavy metal ions are potent inhibitors of protein folding. (2008) (185)
- Arsenite interferes with protein folding and triggers formation of protein aggregates in yeast (2012) (132)
- Microwave-assisted extraction of the main phenolic compounds in flaxseed. (2007) (126)
- Evolutionary relationships among aminotransferases (1989) (122)
- Focused microwave-assisted extraction of cocaine and benzoylecgonine from coca leaves. (2002) (122)
- Mechanism of the Targeting Action of DnaJ in the DnaK Molecular Chaperone System* (2003) (116)
- New trends in extraction, identification and quantification of artemisinin and its derivatives. (2001) (114)
- The power stroke of the DnaK/DnaJ/GrpE molecular chaperone system. (1997) (114)
- Disaggregating chaperones: an unfolding story. (2009) (107)
- Functional investigation of methanol dehydrogenase-like protein XoxF in Methylobacterium extorquens AM1. (2010) (103)
- Cytoplasmic aspartate aminotransferase: syncatalytic sulfhydryl group modification. (1973) (103)
- Mutation in the C-Di-AMP Cyclase dacA Affects Fitness and Resistance of Methicillin Resistant Staphylococcus aureus (2013) (84)
- Extraction of artemisinin and artemisinic acid from Artemisia annua L. using supercritical carbon dioxide. (1997) (82)
- Reversible Thermal Transition in GrpE, the Nucleotide Exchange Factor of the DnaK Heat-Shock System* (2001) (81)
- Control of the DnaK Chaperone Cycle by Substoichiometric Concentrations of the Co-chaperones DnaJ and GrpE* (1998) (77)
- Production of diosgenin by hairy root cultures ofTrigonella foenum-graecum L. (1997) (76)
- Antitrypanosomal quinoline alkaloids from the roots of Waltheria indica. (2014) (73)
- Parameters affecting microwave-assisted extraction of withanolides. (2001) (72)
- The Ethylmalonyl-CoA Pathway Is Used in Place of the Glyoxylate Cycle by Methylobacterium extorquens AM1 during Growth on Acetate* (2011) (71)
- Antifungal Quinoline Alkaloids from Waltheria indica. (2016) (68)
- Urate oxidase in primate phylogenesis. (1970) (66)
- Optimisation of accelerated solvent extraction of cocaine and benzoylecgonine from coca leaves (2001) (61)
- Evolutionary relationships among pyridoxal-5'-phosphate-dependent enzymes. Regio-specific alpha, beta and gamma families. (1994) (61)
- Sequence-specific rates of interaction of target peptides with the molecular chaperones DnaK and DnaJ. (1998) (59)
- Enantioseparation of atropine by capillary electrophoresis using sulfated beta-cyclodextrin: application to a plant extract. (2000) (57)
- Induction of antibodies against murine full-length prion protein in wild-type mice (2002) (56)
- Chemical study and anti‐inflammatory, analgesic and antioxidant activities of the leaves of Aristotelia chilensis (Mol.) Stuntz, Elaeocarpaceae (2011) (56)
- Hairy roots of Datura candida×D. aurea: effect of culture medium composition on growth and alkaloid biosynthesis (1998) (55)
- Screening and determination of sibutramine in adulterated herbal slimming supplements by HPTLC-UV densitometry (2014) (55)
- The Proline-rich Antibacterial Peptide Bac7 Binds to and Inhibits in vitro the Molecular Chaperone DnaK (2009) (54)
- Simultaneous determination of scopolamine, hyoscyamine and littorine in plants and different hairy root clones of Hyoscyamus muticus by micellar electrokinetic chromatography. (2000) (53)
- Capillary electrophoresis‐diode array detection — electrospray mass spectrometry for the analysis of selected tropane alkaloids in plant extracts (1999) (52)
- Neurotoxicity of prion peptide 106‐126 not confirmed (1999) (52)
- Homology of 1-aminocyclopropane-1-carboxylate synthase, 8-amino-7-oxononanoate synthase, 2-amino-6-caprolactam racemase, 2,2-dialkylglycine decarboxylase, glutamate-1-semialdehyde 2,1-aminomutase and isopenicillin-N-epimerase with aminotransferases. (1994) (52)
- Mechanistic probes for enzymatic reactions. Oxidation-reduction indicators as oxidants of intermediary carbanions (studies with aldolase, aspartate aminotransferase, pyruvate decarboxylase, and 6-phosphogluconate dehydrogenase). (1973) (52)
- Fast sampling method for mammalian cell metabolic analyses using liquid chromatography–mass spectrometry (2014) (51)
- Amino acid analysis by high-performance liquid chromatography after derivatization with 1-fluoro-2,4-dinitrophenyl-5-L-alanine amide. (1989) (51)
- Isolation, crystallization and preliminary crystallographic data of aspartate aminotransferase from chicken heart mitochondria. (1977) (51)
- Mutations in the interdomain linker region of DnaK abolish the chaperone action of the DnaK/DnaJ/GrpE system (2001) (50)
- Homology of pyridoxal-5'-phosphate-dependent aminotransferases with the cobC (cobalamin synthesis), nifS (nitrogen fixation), pabC (p-aminobenzoate synthesis) and malY (abolishing endogenous induction of the maltose system) gene products. (1993) (49)
- The covalent structure of mitochondrial aspartate aminotransferase from chicken. Identification of segments of the polypeptide chain invariant specifically in the mitochondrial isoenzyme. (1983) (49)
- Catapult mechanism renders the chaperone action of Hsp70 unidirectional. (1998) (49)
- Analytical discrimination of poisonous and nonpoisonous chemotypes of giant fennel (Ferula communis L.) through their biologically active and volatile fractions. (2006) (47)
- Cadmium Causes Misfolding and Aggregation of Cytosolic Proteins in Yeast (2017) (47)
- Bacterial selenocysteine synthase--structural and functional properties. (1998) (47)
- Selectivity manipulation using nonaqueous capillary electrophoresis. Application to tropane alkaloids and amphetamine derivatives (1998) (47)
- Tuning of DnaK Chaperone Action by Nonnative Protein Sensor DnaJ and Thermosensor GrpE* (2006) (47)
- The open/closed conformational equilibrium of aspartate aminotransferase. Studies in the crystalline state and with a fluorescent probe in solution. (1991) (46)
- Syncatalytic modification of a functional tyrosyl residue in aspartate aminotransferase. (1970) (46)
- Non-aqueous capillary electrophoresis with diode array and electrospray mass spectrometric detection for the analysis of selected steroidal alkaloids in plant extracts. (2001) (46)
- THE EVAPORATIVE LIGHT SCATTERING DETECTOR : SOME APPLICATIONS IN PHARMACEUTICAL ANALYSIS (1997) (45)
- Spontaneous deamidation and isomerization of Asn108 in prion peptide 106-126 and in full-length prion protein. (1999) (45)
- Biosynthesis and topogenesis of aspartate aminotransferase isoenzymes in chicken embryo fibroblasts. The precursor of the mitochondrial isoenzyme is either imported into mitochondria or degraded in the cytosol. (1982) (44)
- Comparison of the evolution rates of cytosolic and mitochondrial aspartate aminotransferase (1978) (44)
- Thermosensor Action of GrpE (2003) (43)
- High-yield production of tropane alkaloids by hairy-root cultures of aDatura candida hybrid (1989) (43)
- Mechanism of racemization of amino acids by aspartate aminotransferase. (1992) (43)
- Screening and Engineering the Synthetic Potential of Carboxylating Reductases from Central Metabolism and Polyketide Biosynthesis. (2015) (43)
- Potassium ions and the molecular-chaperone activity of DnaK. (1996) (43)
- Conversion of Aspartate Aminotransferase into anl-Aspartate β-Decarboxylase by a Triple Active-site Mutation* (1999) (43)
- Cell-free synthesis of a putative precursor of mitochondrial aspartate aminotransferase with higher molecular weight. (1980) (43)
- Reaction of tetranitromethane with protein sulfhydryl groups. Inactivation of aldolase. (1968) (42)
- Comparison of Folding Rates of Homologous Prokaryotic and Eukaryotic Proteins* (2000) (42)
- Active-site Arg → Lys Substitutions Alter Reaction and Substrate Specificity of Aspartate Aminotransferase* (1997) (42)
- Essential oils from normal and hairy roots of Valeriana officinalis var. sambucifolia (1995) (42)
- Peptide mapping of protein bands from polyacrylamide gel electrophoresis by chemical cleavage in gel pieces and re-electrophoresis. (1982) (42)
- Chemical evidence for syncatalytic conformational changes in aspartate aminotransferase (1971) (41)
- Syncatalytic conformational changes in mitochondrial aspartate aminotransferases. Evidence from modification and demodification of Cys 166 in the enzyme from chicken and pig. (1978) (41)
- Experimental design for enantioselective separation of celiprolol by capillary electrophoresis using sulfated β‐cyclodextrin (1999) (41)
- Calystegines in wild and cultivated Erythroxylum species. (2005) (40)
- Calystegine distribution in some solanaceous species. (2001) (40)
- Misfolding and aggregation of nascent proteins: a novel mode of toxic cadmium action in vivo (2017) (39)
- Identification of isomeric tropane alkaloids from Schizanthus grahamii by HPLC-NMR with loop storage and HPLC-UV-MS/SPE-NMR using a cryogenic flow probe. (2006) (39)
- Mitochondrial aspartate aminotransferase 27/32-410. Partially active enzyme derivative produced by limited proteolytic cleavage of native enzyme. (1980) (38)
- Survey of pyrrolizidine alkaloids in teas and herbal teas on the Swiss market using HPLC-MS/MS (2014) (38)
- cis‐Effect of DnaJ on DnaK in ternary complexes with chimeric DnaK/DnaJ‐binding peptides (2004) (38)
- Supercritical fluid extraction and chromatography of artemisinin and artemisinic acid. An improved method for the analysis of Artemisia annua samples (1997) (38)
- Biosynthesis of aspartate aminotransferases. Both the higher molecular weight precursor of mitochondrial aspartate aminotransferase and the cytosolic isoenzyme are synthesized on free polysomes. (1982) (38)
- Tropane Alkaloids in Transformed Roots of Datura quercifolia. (1994) (37)
- Cell‐free synthesis of the one‐chain precursor of a major intrinsic protein complex of the small‐intestinal brush border membrane (pro‐sucrase—isomaltase) (1981) (37)
- High-yield production of valepotriates by hairy root cultures of Valeriana officnalis L. var. sambucifolia Mikan (1992) (37)
- Metabolite Profiling Uncovers Plasmid-Induced Cobalt Limitation under Methylotrophic Growth Conditions (2009) (37)
- Changing the reaction specificity of a pyridoxal-5'-phosphate-dependent enzyme. (1995) (36)
- Evolutionary relationships among aminotransferases. Tyrosine aminotransferase, histidinol-phosphate aminotransferase, and aspartate aminotransferase are homologous proteins. (1989) (36)
- Chemical constituents from Waltheria indica exert in vitro activity against Trypanosoma brucei and T. cruzi. (2015) (36)
- Capillary electrophoresis for the analysis of tropane alkaloids: pharmaceutical and phytochemical applications. (1998) (35)
- Interspecies comparison of cytosolic and mitochondrial aspartate aminotransferases. Evidence for a more conservative evolution of the mitochondrial isoenzyme. (1977) (35)
- Plants as a source of therapeutic and health products. (2012) (35)
- Application of central composite designs in the supercritical fluid extraction of tropane alkaloids in plant extracts (1999) (35)
- Nonaqueous capillary electrophoresis for the analysis of selected tropane alkaloids in a plant extract (1999) (35)
- Extraction and analysis of different Cannabis samples by headspace solid-phase microextraction combined with gas chromatography-mass spectrometry. (2005) (34)
- Reaction of an aldolase-substrate intermediate with tetranitromethane. (1968) (33)
- Mitochondrial protein charge (1991) (33)
- Cocaine distribution in wild Erythroxylum species. (2006) (33)
- Experimental design in supercritical fluid extraction of cocaine from coca leaves. (2000) (33)
- High-throughput tandem-microwell assay identifies inhibitors of the hydrogen sulfide signaling pathway. (2013) (32)
- Catalytic activity in crystals of mitochondrial aspartate aminotransferase as detected by microspectrophotometry. (1978) (32)
- The primary structure of the precursor of chicken mitochondrial aspartate aminotransferase. Cloning and sequence analysis of cDNA. (1985) (32)
- d-Peptide Ligands for the Co-chaperone DnaJ* (1998) (32)
- Interdomain communication in the molecular chaperone DnaK. (2003) (31)
- d-Peptides as Inhibitors of the DnaK/DnaJ/GrpE Chaperone System* (2003) (31)
- High-precision heteronuclear 2D NMR experiments using 10-ppm spectral window to resolve carbon overlap. (2009) (31)
- Active-site labeling of aspartate aminotransferases by the beta,gamma-unsaturated amino acid vinylglycine. (1977) (31)
- Tropane Alkaloids: Old Drugs Used in Modern Medicine (2000) (31)
- Prediction of the Passive Intestinal Absorption of Medicinal Plant Extract Constituents with the Parallel Artificial Membrane Permeability Assay (PAMPA) (2016) (30)
- The three-dimensional structure of mitochondrial aspartate aminotransferase at 4.5 A resolution. (1979) (30)
- Alkaloids of Erythroxylum lucidum stem-bark (1997) (30)
- Carbanion intermediates in the reaction of yeast and muscle aldolase. (1969) (30)
- Reverse pharmacology for developing an anti-malarial phytomedicine. The example of Argemone mexicana (2014) (30)
- Use of a Doehlert design in optimizing the analysis of selected tropane alkaloids by micellar electrokinetic capillary chromatography (1998) (29)
- Nonaqueous versus aqueous capillary electrophoresis for the dosage of N-butylscopolamine in various pharmaceutical formulations. (1999) (29)
- The enzymatic isolation and fluoride catalysed racemisation of optically active Sarin. (1965) (29)
- Co-Consumption of Methanol and Succinate by Methylobacterium extorquens AM1 (2012) (29)
- Specific irreversible inhibition of enzymes concomitant to the oxidation of carbanionic enzyme-substrate intermediates by hexacyanoferrate (III). (1976) (28)
- The enantiomeric error frequency of aspartate aminotransferase. (1988) (28)
- Characteristics of growth and tropane alkaloid production in Hyoscyamus albus hairy roots transformed with Agrobacterium rhizogenes A4 (1992) (28)
- In vitro shoot and root organogenesis, plant regeneration and production of tropane alkaloids in some species of Schizanthus. (2006) (28)
- The apo-holo hybrid of cytosolic aspartate aminotransferase, preparation and studies on subunit interactions. (1974) (28)
- Aspartate aminotransferase with the pyridoxal-5'-phosphate-binding lysine residue replaced by histidine retains partial catalytic competence. (1990) (27)
- Multi-targeted screening of botanicals in food supplements by liquid chromatography with tandem mass spectrometry. (2013) (27)
- Crystal structures and solution studies of oxime adducts of mitochondrial aspartate aminotransferase. (1996) (27)
- Targeted Isolation of Monoterpene Indole Alkaloids from Palicourea sessilis. (2017) (27)
- Development and validation of a capillary zone electrophoresis method for the determination of atropine, homatropine and scopolamine in ophthalmic solutions. (1997) (27)
- Production of valepotriates by hairy root cultures of Centranthus ruber DC (1995) (27)
- Micellar electrokinetic capillary chromatography for selected tropane alkaloid analysis in plant extract (1997) (26)
- Conversion of Tyrosine Phenol-lyase to Dicarboxylic Amino Acid β-Lyase, an Enzyme Not Found in Nature* (1999) (26)
- Syncatalytic sulfhydryl group modification in mitochondrial aspartate aminotransferase from chicken and pig heart. (1975) (26)
- Empirical calculation of the relative free energies of peptide binding to the molecular chaperone DnaK (2000) (26)
- Quaternary indole alkaloids from the stem bark of Strychnos guianensis. (2000) (25)
- Alkaloids of Erythroxylum monogynum root-bark (1995) (25)
- Reaction of the carbanionic aldolase-substrate intermediate with tetranitromethane. Identification of the products, hydroxypyruvaldehyde phosphate and D-5-ketofructose 1,6-diphosphate. (1972) (25)
- An iridoid diester from valeriana officinalis var. sambucifolia hairy roots (1995) (25)
- Precursor of mitochondrial aspartate aminotransferase synthesized in Escherichia coli is complexed with heat-shock protein DnaK. (1992) (25)
- Influence of plant matrix on microwave-assisted extraction process. The case of diosgenin extracted from fenugreek (Trigonella foenum-graecum L.). (2007) (25)
- Mutant aspartate aminotransferase (K258H) without pyridoxal-5'-phosphate-binding lysine residue. Structural and catalytic properties. (1993) (24)
- A novel approach to inhibit intracellular vitamin B6‐dependent enzymes: proof of principle with human and plasmodium ornithine decarboxylase and human histidine decarboxylase (2011) (23)
- In vitro import into mitochondria of the precursor of mitochondrial aspartate aminotransferase. (1986) (23)
- Anti-inflammatory and antiproliferative diterpenoids from Plectranthus scutellarioides. (2018) (23)
- Separation of four isomeric tropane alkaloids from Schizanthus grahamii by non-aqueous capillary electrophoresis. (2005) (23)
- Independent quantitation of the mitochondrial and the cytosolic isoenzyme of aspartate aminotransferase in chicken tissues by radioimmunoassays. (1981) (23)
- Substitution of apolar residues in the active site of aspartate aminotransferase by histidine. Effects on reaction and substrate specificity. (1995) (22)
- Crystalline aspartate aminotransferase: lattice-induced functional asymmetry of the two subunits. (1983) (22)
- Cancer chemopreventive activity of compounds isolated from Waltheria indica. (2017) (22)
- The mature form of imported mitochondrial proteins undergoes conformational changes upon binding to isolated mitochondria. (1993) (22)
- Purification and some Properties of Aldolase-Isoenzymes from Bovine Brain and Muscle. 13th. Communication on Aldolases (1967) (22)
- Validated capillary electrophoresis method for the determination of atropine and scopolamine derivatives in pharmaceutical formulations. (1998) (21)
- Immediate response of the DnaK molecular chaperone system to heat shock (2004) (21)
- Biochemistry of Vitamin B6 (1987) (21)
- Absolute configuration of tropane alkaloids bearing two alpha,beta-unsaturated ester functions using electronic CD spectroscopy: application to (R,R)-trans-3-hydroxysenecioyloxy-6-senecioyloxytropane. (2008) (21)
- Conformational changes in aspartate aminotransferase. Effect of active site ligands on peptide hydrogen-deuterium exchange. (1985) (21)
- L'extraction en phase supercritique des substances d'origine végétale (1995) (20)
- Mitochondrial and cytosolic aspartate aminotransferase from chicken: activity toward aromatic amino acids. (1978) (20)
- Kinetic study of littorine rearrangement in Datura innoxia hairy roots by (13)C NMR spectroscopy. (2002) (20)
- Focused microwave-assisted extraction combined with solid-phase microextraction and gas chromatography-mass spectrometry for the selective analysis of cocaine from coca leaves. (2006) (20)
- NASCA-HMBC, a new NMR methodology for the resolution of severely overlapping signals: application to the study of agathisflavone. (2012) (20)
- A new antifungal and antiprotozoal bibenzyl derivative from Gavilea lutea (2018) (20)
- Structural basis for the catalytic activity of aspartate aminotransferase K258H lacking the pyridoxal 5'-phosphate-binding lysine residue. (1994) (20)
- The Importance of Having Thermosensor Control in the DnaK Chaperone System* (2005) (20)
- Rapid liquid chromatographic-mass spectrometric analysis of withanolides in crude plant extracts by use of a monolithic column (2002) (20)
- Chemical composition of the essential oil from Algerian Genista quadriflora Munby and determination of its antibacterial and antifungal activities (2016) (20)
- Use of porous graphitic carbon column for the separation of natural isomeric tropane alkaloids by capillary LC and mass spectrometry. (2006) (20)
- Structure of the genes of two homologous intracellularly heterotopic isoenzymes. Cytosolic and mitochondrial aspartate aminotransferase of chicken. (1990) (19)
- Chemical modification of a functional arginyl residue (Arg 292) of mitochondrial aspartate aminotransferase. Identification as the binding site for the distal carboxylate group of the substrate. (1982) (19)
- Structural Studies of the Catalytic Reaction Pathway of a Hyperthermophilic Histidinol-phosphate Aminotransferase* (2004) (19)
- The heat-sensitive Escherichia coli grpE280 phenotype: impaired interaction of GrpE(G122D) with DnaK. (2005) (19)
- Antiproliferative effects of withanolides from Withania adpressa. (2009) (18)
- Reaction of cytoplasmic aspartate aminotransferase with tetranitromethane. (1973) (18)
- Alkaloids of hairy root cultures of a Datura candida hybrid (1990) (18)
- Paracatalytic enzyme modification by oxidation of enzyme-substrate carbanion intermediates. (1977) (17)
- Formation of hydroxypyruvaldehyde phosphate in human erythrocytes. (1981) (17)
- Irreversible inactivation of pyruvate decarboxylase in the presence of substrate and an oxidant. An example of paracatalytic enzyme inactivation. (1979) (17)
- Study of factors influencing pressurised solvent extraction of polar steroids from plant material. Application to the recovery of withanolides (2001) (17)
- The reactive sulfhydryl groups of cytoplasmic aspartate aminotransferase. Localization in the primary structure and spectral properties of their mixed disulfide derivatives with N-dansylcysteine. (1974) (17)
- Conspicuous degree of homology between the mitochondrial aspartate aminotransferases from chicken and pig heart. (1975) (17)
- Expression of cDNAs encoding the precursor and the mature form of chicken mitochondrial aspartate aminotransferase in Escherichia coli. (1987) (17)
- Rapid high performance liquid chromatographic quantification of valepotriates in hairy root cultures of Valeriana officinalis L. var. sambucifolia Mikan (1994) (17)
- Withanolides from Withania adpressa (2007) (17)
- Evolutionary and Biosynthetic Aspects of Aspartate Aminotransferase Isoenzymes and Other Aminotransferases (1990) (17)
- Pyridoxal 5′-Phosphate-dependent Catalytic Antibody* (1996) (16)
- Molecular biodiversity and recent analytical developments: a marriage of convenience. (2014) (16)
- Development and validation of liquid chromatography and capillary electrophoresis methods for acarbose determination in pharmaceutical tablets. (1998) (16)
- Determination of artemisinin and artemisinic acid by capillary and packed supercritical fluid chromatography (1997) (16)
- Rates of evolution of pyridoxal-5'-phosphate-dependent enzymes. (2000) (16)
- Reported channel formation by prion protein fragment 106–126 in planar lipid bilayers cannot be reproduced (2000) (16)
- Molecular evolution of B6 enzymes: Binding of pyridoxal-5'-phosphate and Lys41Arg substitution turn ribonuclease A into a model B6 protoenzyme (2008) (16)
- Non-native Proteins as Newly-Identified Targets of Heavy Metals and Metalloids (2011) (15)
- Use of borate complexation for the separation of non-UV-absorbing calystegines by capillary electrophoresis. (2000) (15)
- 5',6'-dehydroguiachrysine and 5',6'-dehydroguiaflavine, two curarizing quaternary indole alkaloids from the stem bark of Strychnos guianensis. (2001) (15)
- Structure and mechanism of a cysteine sulfinate desulfinase engineered on the aspartate aminotransferase scaffold. (2011) (15)
- Production of glycolate by oxidation of the 1,2-dihydroxyethyl-thamin-diphosphate intermediate of transketolase with hexacyanoferrate(III) or H2O2. (1980) (15)
- Sequential chemical modifications of tyrosyl residues in alkaline phosphatase of Escherichia coli. (1971) (15)
- Spectral aliasing: a super zoom for 2D-NMR spectra. Principles and applications. (2010) (15)
- Recognizing very distant sequence relationships among proteins by family profile analysis (1999) (14)
- A novel acylated flavonol glycoside isolated from Brunfelsia grandiflora ssp. grandiflora. Structure elucidation by gradient accelerated NMR spectroscopy at 14T (2000) (14)
- Paracatalytic modification of aldolase: a side reaction of the catalytic cycle resulting in irreversible blocking of two active-site lysyl residues. (1979) (14)
- Active Immunization of Mice with an Aβ-Hsp70 Vaccine (2004) (14)
- The stereospecific labilization of the C-4' pro-S hydrogen of pyridoxamine 5'-phosphate is abolished in (Lys258----Ala) aspartate aminotransferase. (1987) (13)
- Bioactive metabolites from the leaves of Withania adpressa (2018) (13)
- Grahamines A-E, cyclobutane-centered tropane alkaloids from the aerial parts of Schizanthus grahamii. (2011) (13)
- Guiaflavine, a new bisindole quaternary alkaloid from the stem bark of Strychnos guianensis. (1999) (13)
- Stereochemical constraint in the evolution of pyridoxal‐5′‐phosphate‐DApenDAnt enzymes. A hypothesis (1996) (13)
- Comment on the manuscript of Muñoz M.A. et al. published in Phytochemistry Letters (2012) 5: 450–454 entitled "Absolute configuration and stereochemical analysis of 3α,6β-dibenzoyloxytropane" (2012) (13)
- Comparison of growth properties, alkaloid production and water uptake of two selected Datura hairy root lines (2004) (12)
- Analysis of isomeric tropane alkaloids from Schizanthus grahamii by very fast gas chromatography. (2006) (12)
- Paracatalytic self-inactivation of fructose-1,6-bisphosphate aldolase. Structure of the crosslink formed at the active site. (1993) (12)
- Monoclonal antibodies against Nalpha-(5'-phosphopyridoxyl)-L-lysine. Screening and spectrum of pyridoxal 5'-phosphate-dependent activities toward amino acids. (1997) (12)
- Headspace solid-phase microextraction of pesticide residues in Cannabis samples (2006) (12)
- Chirality and Numbering of Substituted Tropane Alkaloids (2011) (12)
- Occurrence of circadian rhythms in hairy root cultures grown under controlled conditions. (2004) (12)
- The precursor of mitochondrial aspartate aminotransferase is imported into mitochondria faster than the homologous cytosolic isoenzyme with the same presequence attached. (1991) (11)
- Tropane Alkaloids of the Aerial Parts of Schizanthus tricolor (2007) (11)
- The reaction of cytoplasmic aspartate aminotransferase with bromopyruvate. Syncatalytic modification simulates affinity labeling. (1974) (11)
- Schizanthines N, O, and P, tropane alkaloids from the aerial parts of Schizanthus tricolor. (2011) (11)
- Structure of cDNA of cytosolic aspartate aminotransferase of chicken and its expression in E. coli. (1989) (11)
- A spectrophotometric determination of carbanions with tetranitromethane (1970) (11)
- Bioactive Azepine-Indole Alkaloids from Psychotria nemorosa. (2020) (11)
- Aspartate aminotransferase. Determination of the active site occupancy pattern indicates independent transamination of the two subunits. (1977) (11)
- Analysis of Tropane Alkaloids in Biological Matrices (2007) (11)
- The reaction of alkylmagnesium halides with thiophosphoryl chloride. I. Formation of bi(dialkylphosphinothioyl) compounds (2010) (10)
- Syncatalytic conformational changes in aspartate aminotransferase determined by hydrogen-deuterium exchange. (1978) (10)
- Urate oxidase in primates. (1970) (10)
- Trigonella Species: In Vitro Culture and Production of Secondary Metabolites (2002) (10)
- Stereospecific labilization of the C-4' pro-S hydrogen of pyridoxamine 5'-phosphate in aspartate aminotransferase. Activators and inhibitors. (1987) (10)
- Experimental system for real‐time assessment of potential changes in protein conformation induced by electromagnetic fields (2013) (10)
- Molecular-dynamics simulation of domain movements in aspartate aminotransferase. (1996) (10)
- Assay for aliphatic amino acid decarboxylases by high-performance liquid chromatography. (1989) (10)
- Methods of Analysis: Tropane Alkaloids from Plant Origin (2013) (10)
- The pyridoxal‐5′‐phosphate‐dependent catalytic antibody 15A9: its efficiency and stereospecificity in catalysing the exchange of the α‐protons of glycine (1998) (10)
- Isomeric tropane alkaloids from the aerial parts of Schizanthus tricolor. (2010) (10)
- Alkaloids as Inhibitors of Monoamine Oxidases and Their Role in the Central Nervous System (2014) (10)
- Active immunization of mice with an Abeta-Hsp70 vaccine. (2004) (9)
- Genes of nuclear encoded mitochondrial proteins: evidence for a variant of the 3' splice-site consensus sequence. (1987) (9)
- Stereospecific labilization of the C-4' pro-S hydrogen of pyridoxamine 5'-phosphate in aspartate aminotransferase. (1986) (9)
- Syncatalytic modification of cytoplasmic aspartate aminotransferase: Identification of a peptide containing the modified cysteinyl residue (1972) (9)
- The inactivation by oximes of sarin and soman in plasma from various species. I. The influence of diacetylmonoxime on the hydrolysis of sarin. (1971) (9)
- Oxidation of the carbanion intermediate of transaldolase by hexacyanoferrate (III). (1976) (9)
- Generation of an Escherichia coli strain growing on methanol via the ribulose monophosphate cycle (2022) (9)
- Evaluation of solid-phase microextraction desorption parameters for fast GC analysis of cocaine in coca leaves. (2006) (8)
- Shift in pH-rate profile and enhanced discrimination between dicarboxylic and aromatic substrates in mitochondrial aspartate aminotransferase Y70H. (1994) (8)
- Differential effects of molecular chaperones on refolding of homologous proteins (1995) (8)
- Three-dimensional structure of mitochondrial aspartate aminotransferase and some functional derivatives: implications for its mode of action. (1984) (8)
- Regiospecific Synthesis of 1,4,5-Trisubstituted 1,2,3-Triazoles via Enolate–Azide Cycloaddition between 1,3-Dicarbonyl Compounds and Aryl Azides (2016) (8)
- Amino acid analysis by high-performance liquid chromatography after derivatization with 1-fluoro-2,4-dinitrophenyl-5-L-alanine amide (Marfey's reagent). (2000) (7)
- De stereospecifieke enzymatische hydrolyse van sarin in plasma (1967) (7)
- Structure and Dynamic of Three Indole Alkaloids from the Campylospermum Genus (Ochnaceae) (2013) (7)
- Cytosolic aspartate aminotransferase. Studies on subunit interactions with the apo/holo hybrid dimer. (1978) (7)
- A diagonal procedure for isolating sulfhydryl peptides alkylated with N-ethylmaleimide. (1980) (7)
- Quality assessment of Sclerocarya birrea leaves and leaves products from Burkina Faso based on fingerprinting using HPTLC (2020) (7)
- High affinity binding of hydrophobic and autoantigenic regions of proinsulin to the 70 kDa chaperone DnaK (2010) (7)
- Detection of ligand-induced and syncatalytic conformational changes of enzymes by differential chemical modification. (1982) (7)
- Inability of unpacked gooseneck liners to stop the sample liquid after injection with band formation (fast autosampler) into hot GC injectors. (2004) (7)
- SYNTHESIS AND ANTIFUNGAL ACTIVITY OF DIARYL HYDRAZONES FROM 2,4-DINITROPHENYLHYDRAZINE (2016) (7)
- The Roles of Tyr70 and Tyr225 in Aspartate Aminotransferase Assessed by Analysing the Effects of Mutations on the Multiple Reactions of the Substrate Analogue Serine O‐Sulphate (1995) (7)
- Degradation of the precursor of mitochondrial aspartate aminotransferase in chicken embryo fibroblasts. (1988) (7)
- Biosynthesis of aspartate aminotransferases. (1984) (7)
- Medicinal Plants of Chile: Evaluation of their Anti-Trypanosoma cruzi Activity (2013) (7)
- Analysis of the neurotoxin anisatin in star anise by LC-MS/MS (2013) (6)
- Determination of alkaloids in endemic Genista quadriflora Munby (Fabaceae) (2014) (6)
- Pyridine-4(1H)-one Alkaloids from Waltheria indica as Antitrypanosomatid Agents. (2020) (6)
- Pyridoxal-5'-phosphate-dependent catalytic antibodies. (2002) (6)
- Synthesis and in vitro evaluation of tropane halogenated-derivatives against malaria, sleeping sickness, Chagas disease and leishmaniasis. (2014) (6)
- The aspartate aminotransferase-catalysed exchange of the alpha-protons of aspartate and glutamate: the effects of the R386A and R292V mutations on this exchange reaction. (1999) (6)
- Catalytic activity of non-cross-linked microcrystals of aspartate aminotransferase in poly(ethylene glycol). (1983) (6)
- Centranthus Species: In Vitro Culture and the Production of Valepotriates and Other Secondary Metabolites (1999) (6)
- Structural Basis for D-Amino Acid Transamination by the Pyridoxal 5′-Phosphate-dependent Catalytic Antibody 15A9* (2006) (6)
- Syncatalytic enzyme modification: characteristic features and differentiation from affinity labeling. (1977) (6)
- Analysis of Cannabis material by headspace solid-phase microextraction combined with gas chromatography-mass spectrometry (2004) (6)
- Evolutionary Relationships among Pyridoxal Phosphate-Dependent Enzymes (1991) (5)
- Chemistry and biological activity of alkaloids from the genus Schizanthus (2019) (5)
- Inhibition of Cholinergic Contractions of Rat Ileum by Tropane-Type Alkaloids Present in Schizanthus hookeri (2013) (5)
- The assignment of the vibrational frequency of the P = S group (2010) (5)
- Synthesis and Antifungal activity of Phenacyl Azoles (2014) (5)
- Unexpected occurrence of caffeine in sleep-inducing herbal teas. (2014) (4)
- Characterization of Positional and Configurational Tropane Alkaloid Isomers by Combining GC with NPD, MS and FTIR (2009) (4)
- Modulation of the activity of mitochondrial aspartate aminotransferase H352C by the redox state of the engineered interdomain disulfide bond. (1994) (4)
- Isolation of sulfhydryl peptides alkylated with N-ethylmaleimide by diagonal electrophoresis. (1983) (4)
- Stability of corticosteroids in zinc oxide-containing hydrophilic paste and lipophilic ointment (1991) (4)
- Tropane Alkaloid Production in Datura quercifolia Hairy Roots (1993) (4)
- GC/MS Examination of Hairy Roots of a Datura candida Hybrid for Alkaloids (1989) (4)
- Pyridoxal-5'-phosphate-dependent catalytic antibodies. (2002) (4)
- Transformation in Datura Species (1993) (3)
- Hygroline derivatives from Schizanthus tricolor and their anti-trypanosomatid and antiplasmodial activities. (2021) (3)
- TOWARDS THE SPATIAL STRUCTURE OF MITOCHONDRIAL ASPARTATE-AMINOTRANSFERASE (1978) (3)
- New Trends in the Extraction of Natural Products: Microwave‐Assisted Extraction and Pressurized Liquid Extraction (2014) (3)
- Crystallographic studies on the mechanism of action of mitochondrial aspartate aminotransferase. (1984) (3)
- Amino acid sequences and hapten binding of catalytic and noncatalytic antibodies against N(alpha)-(5'-phosphopyridoxyl)-L-lysine. (2000) (3)
- Detection of a very rapid first phase in complex formation of DnaK and peptide substrate (2002) (3)
- Subcellular distribution of aspartate aminotransferase isoenzymes in chicken heart: quantitative study. (1982) (3)
- Phytochemical Investigation of the Roots of Ipomoea asarifolia and Antiproliferative Activity of the Isolated Compounds against Multiple Myeloma Cells. (2021) (3)
- Two New Hygroline and Tropane Alkaloids Isolated from Schizanthus Hookeri and S. Tricolor (Solanaceae) (2017) (2)
- Amino Acid Analysis by Precolumn Derivatization with 1-Fluoro-2,4-Dinitrophenyl-5-I-Alanine Amide (Marfey’s Reagent) (2009) (2)
- Investigation of potential EMF induced conformational changes of thermosensor protein GrpE of E. Coli in real time (2010) (2)
- STABILITY OF PREDNISOLONE and PREDNISOLONE ACETATE IN VARIOUS VEHICLES USED IN SEMI‐SOLID TOPICAL PREPARATIONS (1990) (2)
- Passive Intestinal Absorption of Representative Plant Secondary Metabolites: A Physicochemical Study (2017) (2)
- 407 The mode of Action of Diacetylmonoxime (DAM) as an Antidote against Sarin Poisoning (1961) (2)
- H2O2 oxidizes an aldolase dihydroxyacetone phosphate intermediate to hydroxymethylglyoxal phosphate (1974) (2)
- New cyclobutane-containing tropane alkaloids from the aerial parts of Schizanthus grahamii (2009) (2)
- Determination of Artemisinin in Artemisia annua L. by Off-Line Supercritical Fluid Extraction and Supercritical Fluid Chromatography Coupled to an Evaporative Light-Scattering Detector (2000) (2)
- A comment on: ‘Homology of the NifS family of proteins to a new class of pyridoxal phosphate‐dependent enzymes’, by Christos Ouzounis and Chris Sander (1993) FEBS Lett. 322, 159‐164 (1993) (2)
- Monoclonal Antibodies against Nα-(5′-Phosphopyridoxyl)-L-lysine (1997) (2)
- Purification and some properties of aldolase-isoenzymes from bovine brain and muscle. (1967) (2)
- Visual detection of fructose-1,6-P2 aldolase after electrophoresis by its oxidative paracatalytic reaction. (1980) (1)
- Anti-inflammatory and Quinone Reductase-Inducing Compounds from Beilschmiedia mannii (2018) (1)
- High-throughput prediction of passive intestinal absorption of natural products and plant extracts with the PAMPA assay (2015) (1)
- Studies on the Mechanism of Action of Aspartate Aminotransferase (AspAT) by Cryoenzymological and Isotope Techniques (1987) (1)
- Metabolic characterization of M . extorquens AM 1 on acetate 1 The ethylmalonyl-CoA pathway is used in place of the glyoxylate cycle by Methylobacterium extorquens AM 1 during growth on acetate * (2011) (1)
- The roles of Tyr70 and Tyr225 in aspartate aminotransferase assessed by analysing the effects of mutations on the multiple reactions of the substrate analogue serine o-sulphate. (1995) (1)
- CATALYTIC PROPERTIES OF CRYSTALLINE MITOCHONDRIAL ASPARTATE AMINOTRANSFERASE, LATTICE-INDUCED FUNCTIONAL ASYMMETRY OF THE TWO SUBUNITS (1981) (1)
- Linear dichroism measurements on single crystals of mitochondrial aspartate aminotransferase. (1984) (1)
- Valeriana Species: In Vitro Culture and the Formation of Sesquiterpenes and Valepotriates (1995) (1)
- HPTLC determination of sibutramine in adulterated herbal slimming supplements (2014) (1)
- Genes, Biosynthesis, and Intracellular Processing of the Iso-Enzymes of Aspartate Aminotransferase (1987) (1)
- Recent Aspects of Tropane Alkaloid Biosynthesis in Erythroxylum zambesiacum Stem Bark (1993) (1)
- Vinblastine inhibits the maturation of the precursor of mitochondrial aspartate aminotransferase. Vincristine and six other cytoskeleton inhibitors do not show this effect. (1983) (1)
- Biochemistry of vitamin B「下6下」 : proceedings of the 7th International Congress on Chemical and Biological Aspects of Vitamin B「下6下」 Catalysis, held in Turku, Finland, June 22-26, 1987 (1987) (1)
- Isolation and Structure Elucidation of Compounds from Sesamum alatum and Their Antiproliferative Activity against Multiple Myeloma Cells. (2022) (1)
- Antifungal activity of quinoline alkaloids from Waltheria indica (2015) (1)
- BIOSYNTHESIS AND TOPOGENESIS OF CYTOSOLIC AND MITOCHONDRIAL ASPARTATE AMINOTRANSFERASE (1983) (1)
- [On the aldolase in rabbit liver: molecular weight, dissociation into sub-units. On aldolases. 5]. (1965) (1)
- Chemical approaches to intermediates of enzyme catalysis (1970) (1)
- Reaction of imidazole-citrate-deformed glycogen phosphorylase with amino acids. (1993) (1)
- Real‐time assessment of possible electromagnetic‐field‐induced changes in protein conformation and thermal stability (2014) (1)
- Natural products as inhibitors of purine nucleoside phosphorylase, a target against Plasmodium spp (2012) (1)
- ¹H AND 13C NMR SPECTRAL ASSIGNMENTS AND X-RAY CRYSTALLOGRAPHY OF N-(3-(1H-IMIDAZOL-1-YL)PROPYL)-2-PHENYLQUINAZOLIN-4-AMINE (2013) (1)
- Two new isomeric tropane alkaloids from Schizanthus tricolor identified by capillary NMR (2006) (1)
- [Structure and function of enzymes. A brief introduction]. (1974) (1)
- Rapid HPLC Quantification of Valepotriates (1993) (1)
- Linear dichroism measurements on single crystals of the pyridoxal phosphate dependent enzyme mitochondrial aspartate aminotransferase (1984) (1)
- Azepine-Indole Alkaloids From Psychotria nemorosa Modulate 5-HT2A Receptors and Prevent in vivo Protein Toxicity in Transgenic Caenorhabditis elegans (2022) (1)
- Aspartate aminotransferase: studies on conformational adaptions and 3H-transfer during transamination. (1984) (1)
- The reaction of alkylmagnesium halides with thiophosphoryl chloride: II. Formation of dialkylphosphinic chlorides (2010) (1)
- The DnaK Chaperone System at Heat Shock Temperatures : Thermosensor Action of GrpE (2003) (0)
- Assessment of potential EMF induced conformational changes of thermosensor protein GrpE of E. coli (2010) (0)
- Antitrypanocidal activity of quinoline alkaloids from the roots of Waltheria indica (2014) (0)
- Contribution to the study of Strychnos guianensis : purification and structural determination of potentially curarizing quaternary alkaloids (2000) (0)
- Antiproliferative activity of compounds isolated from the root bark of Lannea acida in multiple myeloma cell lines. (2023) (0)
- Short Lecture “From in silico to in vivo: Psychotria nemorosa alkaloids counter protein toxicity in Caenorhabditis elegans” (2022) (0)
- Fab fragment of PLP-dependent catalytic antibody 15A9 in complex with phosphopyridoxyl-D-alanine (2005) (0)
- Conformational changes during catalysis by mitochondrial aspartate aminotransferase (1981) (0)
- Spectral aliasing in 2D-NMR. A straightforward method to considerably increase the resolution of signal clusters and facilitate identification of two cubebin epimers in Drimys winteri (2009) (0)
- The fate of the cholinesterase inhibitor sarin in blood plasma (1967) (0)
- Modern tools to analyse museum samples of curare and psychoactive preparations used by Amazonian tribes (2016) (0)
- Correlation of structure and catalysis by aspartate aminotransferase isoenzymes. (1984) (0)
- Occurrence of Natural Hepatotoxins in Herbal Teas (2015) (0)
- Reply by the authors (1999) (0)
- Raman spectra of trimethyl phosphinesulfide and bis-(dialkylphosphinothioyl) compounds (2010) (0)
- ExperimentalSystemforReal-Time AssessmentofPotentialChangesin ProteinConformationInducedby ElectromagneticFields (2013) (0)
- 5′,6′-Dehydroguiachrysine and 5′,6′-Dehydroguiaflavine, Two Curarizing Quaternary Indole Alkaloids from the Stem Bark of Strychnos guianensis. (2002) (0)
- Reply by the authors1 (2000) (0)
- Monoclonal Antibodies against N a-( 5 *-Phosphopyridoxyl )-L-lysine SCREENING AND SPECTRUM OF PYRIDOXAL 5 9-PHOSPHATE-DEPENDENT ACTIVITIES TOWARD AMINO (1997) (0)
- What Type of Research Is Done in the Laboratory of Pharmaceutical Analytical Chemistry of the University of Geneva? (1997) (0)
- Isolation and identification of six tropane alkaloid derivatives from Schizanthus tricolor, a chilean Solanaceae species (2008) (0)
- Chemistry and biological activity of alkaloids from the genus Schizanthus (2019) (0)
- Production of Valepotoriates by Hairy Root Cultures ofValeriana qfflcinalisvar.sambucifolia (1992) (0)
- PLP-DEPENDENT CATALYTIC ANTIBODY 15A9 IN COMPLEX WITH ITS HAPTEN (2006) (0)
- Conformational changes in mitochondrial aspartate aminotransferase detected by a covalently attached fluorescent probe. (1984) (0)
- Phenolic compounds from the leaves of Ouratea gilgiana and their biological activities (2010) (0)
- ASPARTATE AMINOTRANSFERASE ISOENZYMES: INTRACELLULAR LOCALIZATION AND DISTRIBUTION IN DIFFERENT CHICKEN TISSUES MEASURED BY RADIOIMMUNOASSAY (1981) (0)
- Structure of an engineered aspartate aminotransferase (2011) (0)
- [Multiple forms of aldolase in organ extracts of the rat. On aldolases, 8]. (1966) (0)
- Pyridoxal-5′-phosphate-dependent catalytic antibodies (1996) (0)
- [Inactivation of rabbit muscle and liver aldolase in 4M urea solution]. (1965) (0)
- Synthesis, antitumor activity, 3D-QSAR and molecular docking studies of new iodinated 4-(3H)-quinazolinones 3N-substituted (2022) (0)
- Variant and conserved amino acid residues in the spatial structure of aspartate amino transferases (1979) (0)
- The influence of some oximes on the hydrolysis of sarin and soman in plasma (1965) (0)
- Inhibitors of maturation and degradation of the precursor of mitochondrial aspartate aminotransferase. (1984) (0)
- Mitochondrial aspartate amino transferase studies on its catalytic action in solution and in the crystalline state (1981) (0)
- Misfolding and aggregation of nascent proteins: a novel mode of toxic cadmium action in vivo (2017) (0)
- Engineering of B6 enzymes (2000) (0)
- Chapter 4 Alkaloids as Inhibitors of Monoamine Oxidases and Their Role in the Central Nervous System (2014) (0)
- [Study of the applicability of diacetylmonoxime in humans as an antidote in poisoning with the organophosphate sarin]. (1969) (0)
- 2-(4-Bromophenyl)-N-[3-(1H-imidazol-1-yl)propyl]quinazolin-4-amine (2012) (0)
- DEMONSTRATION OF A PRECURSOR OF MITOCHONDRIAL ASPARTATE AMINOTRANSFERASE (mAATase) IN CULTURED CHICKEN EMBRYO FIBROBLASTS (CEF) (1981) (0)
- Cytoplasmic Aspartate Amimstransferase : Symcatalytic Sulf hydryl Group Modification (2002) (0)
- Antioxidant Activity of Selected Chemical Constituents of Quinchamaliumchilensis (2015) (0)
- Conformational Changes in Aspartate Aminotransferase (2001) (0)
- Cannabis profiling : which analytical strategy to apply ? (2006) (0)
- Coupling of fructose-1,6-P2 to aminated agarose by Schiff base reduction. Affinity chromatography of yeast aldolase (1977) (0)
- The pyridoxal-5'-phosphate-dependent catalytic antibody 15A9: its efficiency and stereospecificity in catalysing the exchange of the alpha-protons of glycine. (1998) (0)
- Evaluation of the hypoglycemic effects of extracts and diterpenoids from Azorella compacta (llareta) (2016) (0)
- Reverse pharmacology of medicinal plants: Good luck or efficient method? (2012) (0)
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What Schools Are Affiliated With Philippe Christen?
Philippe Christen is affiliated with the following schools:
