Philippe Froguel

Q: What Schools Are Affiliated With Philippe Froguel

Philippe Froguel is affiliated with the following schools: University of Lausanne, University of Exeter, Imperial College London, Lille University of Science and Technology, University of Chicago, Queen Mary University of London, Paris Diderot University

Philippe Froguel's AcademicInfluence.com Rankings

Philippe Froguel

Philosophy

#3741

World Rank

#5994

Historical Rank

Logic

#1370

World Rank

#2107

Historical Rank

philosophy Degrees

Philippe Froguel

Biology

#4739

World Rank

#7034

Historical Rank

Genetics

#407

World Rank

#473

Historical Rank

biology Degrees

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Philosophy
Biology

Philippe Froguel's Degrees

Doctorate Medicine Lille University of Science and Technology
PhD Genetics Lille University of Science and Technology

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Philippe Froguel's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity (2001) (4863)
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase (2002) (4166)
Genetic studies of body mass index yield new insights for obesity biology (2015) (3549)
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects (2003) (3033)
A genome-wide association study identifies novel risk loci for type 2 diabetes (2007) (2994)
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction (1998) (2327)
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk (2010) (2087)
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index (2010) (2011)
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes (2012) (1839)
Defining the role of common variation in the genomic and biological architecture of adult human height (2014) (1805)
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis (2010) (1801)
Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3) (1996) (1567)
Variation in FTO contributes to childhood obesity and severe adult obesity (2007) (1529)
Disruption of Adiponectin Causes Insulin Resistance and Neointimal Formation* (2002) (1382)
Common variants near MC4R are associated with fat mass, weight and risk of obesity (2008) (1307)
Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions (2007) (1239)
New genetic loci link adipose and insulin biology to body fat distribution (2014) (1227)
Association analyses of 249,796 individuals reveal eighteen new loci associated with body mass index (2010) (1179)
Genetic associations with human longevity at the APOE and ACE loci (1994) (1074)
Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps (2018) (1028)
A frameshift mutation in human MC4R is associated with a dominant form of obesity (1998) (1022)
Impaired Multimerization of Human Adiponectin Mutants Associated with Diabetes (2003) (994)
Globular Adiponectin Protected ob/ob Mice from Diabetes and ApoE-deficient Mice from Atherosclerosis* (2003) (945)
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility (2014) (933)
The genetic architecture of type 2 diabetes (2016) (927)
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution (2010) (897)
Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity. (2000) (853)
Adipose Tissue in Obesity-Related Inflammation and Insulin Resistance: Cells, Cytokines, and Chemokines (2013) (831)
Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus. (1993) (779)
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways (2012) (758)
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance (2012) (756)
Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries (2018) (735)
Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. (2002) (714)
Genomewide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24. (2000) (702)
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations (2012) (678)
Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations (2009) (653)
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease (2011) (638)
Genomic insights into the origin of farming in the ancient Near East (2016) (637)
Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus (1992) (617)
Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. (2009) (614)
Activating mutations in the ABCC8 gene in neonatal diabetes mellitus. (2006) (591)
Genetic Variation in the β3-Adrenergic Receptor and an Increased Capacity to Gain Weight in Patients with Morbid Obesity (1995) (588)
A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk (2009) (574)
Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human (2012) (573)
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture (2013) (568)
Genome-wide association study identifies five loci associated with lung function (2010) (560)
An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans (2017) (547)
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study (2015) (532)
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma (2011) (526)
Common genetic variation near MC4R is associated with waist circumference and insulin resistance (2008) (523)
Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci (2011) (518)
Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians. (2002) (511)
Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children (2011) (508)
FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity (2007) (488)
Paraoxonase polymorphism Met-Leu54 is associated with modified serum concentrations of the enzyme. A possible link between the paraoxonase gene and increased risk of cardiovascular disease in diabetes. (1997) (484)
Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia (2009) (452)
Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death (2013) (441)
Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus (1992) (434)
Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus (2011) (428)
New gene functions in megakaryopoiesis and platelet formation (2011) (423)
The genetic contribution to non-syndromic human obesity (2009) (414)
Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome llq (1994) (407)
The genetics of human obesity (2005) (391)
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function (2016) (388)
Insulin-IGF2 region on chromosome 11p encodes a gene implicated in HLA-DR4-dependent diabetes susceptibility (1991) (386)
Insulin/Foxo1 Pathway Regulates Expression Levels of Adiponectin Receptors and Adiponectin Sensitivity* (2004) (384)
A genome-wide scan for human obesity genes reveals a major susceptibility locus on chromosome 10 (1998) (381)
TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis (2007) (378)
A genome-wide association meta-analysis identifies new childhood obesity loci (2012) (375)
Insulin Storage and Glucose Homeostasis in Mice Null for the Granule Zinc Transporter ZnT8 and Studies of the Type 2 Diabetes–Associated Variants (2009) (372)
Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits (2013) (365)
Gln-Arg192 polymorphism of paraoxonase and coronary heart disease in type 2 diabetes (1995) (357)
Seventy-five genetic loci influencing the human red blood cell (2012) (357)
Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus (1992) (355)
Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations. (2009) (354)
Genetic fine-mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci (2015) (349)
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals (2016) (347)
Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control study. (2015) (347)
Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice. (1998) (339)
Two New Loci for Body-Weight Regulation Identified in a Joint Analysis of Genome-Wide Association Studies for Early-Onset Extreme Obesity in French and German Study Groups (2010) (337)
Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes (2012) (333)
Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes (2005) (331)
Transcription Factor TCF7L2 Genetic Study in the French Population (2006) (327)
Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat (1996) (324)
Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis (2017) (308)
Detection of human adaptation during the past 2000 years (2016) (302)
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism (2012) (300)
Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders (2013) (299)
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes (2017) (294)
Glucokinase as pancreatic beta cell glucose sensor and diabetes gene. (1993) (294)
Common nonsynonymous variants in PCSK1 confer risk of obesity (2008) (288)
Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity (2014) (287)
A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism. (2002) (287)
Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR (1993) (286)
PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study (2017) (283)
A genome-wide scan for coronary heart disease suggests in Indo-Mauritians a susceptibility locus on chromosome 16p13 and replicates linkage with the metabolic syndrome on 3q27. (2001) (280)
Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus. (1999) (274)
Missense mutations in the pancreatic islet beta cell inwardly rectifying K+ channel gene (KIR6.2/BIR ): a meta-analysis suggests a role in the polygenic basis of Type II diabetes mellitus in Caucasians (1998) (274)
A deletion of the HBII-85 class of small nucleolar RNAs (snoRNAs) is associated with hyperphagia, obesity and hypogonadism. (2009) (273)
Altered Insulin Secretory Responses to Glucose in Diabetic and Nondiabetic Subjects With Mutations in the Diabetes Susceptibility Gene MODY3 on Chromosome 12 (1996) (267)
The genetic abnormality in the beta cell determines the response to an oral glucose load (2002) (264)
Stratifying Type 2 Diabetes Cases by BMI Identifies Genetic Risk Variants in LAMA1 and Enrichment for Risk Variants in Lean Compared to Obese Cases (2012) (263)
A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B (2010) (261)
Identification of 14 new glucokinase mutations and description of the clinical profile of 42 MODY-2 families (1997) (258)
Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02). (2009) (255)
A catalog of genetic loci associated with kidney function from analyses of a million individuals (2019) (252)
Genome-wide analysis identifies 12 loci influencing human reproductive behavior (2016) (250)
Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight (2010) (250)
Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate Loci on 7p and 11p. (2002) (249)
Insertion/deletion polymorphism of the angiotensin-converting enzyme gene is strongly associated with coronary heart disease in non-insulin-dependent diabetes mellitus. (1994) (249)
Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index. (2016) (245)
Genetic interaction of BBS1 mutations with alleles at other BBS loci can result in non-Mendelian Bardet-Biedl syndrome. (2003) (244)
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk (2016) (242)
Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function. (2005) (241)
A Polymorphism Within the G6PC2 Gene Is Associated with Fasting Plasma Glucose Levels (2008) (241)
A novel highly-penetrant form of obesity due to microdeletions on chromosome 16p11.2 (2009) (239)
Prevalence of Melanocortin-4 Receptor Deficiency in Europeans and Their Age-Dependent Penetrance in Multigenerational Pedigrees (2008) (235)
Intracellular retention is a common characteristic of childhood obesity-associated MC4R mutations. (2003) (234)
KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron (2012) (232)
Systems medicine and integrated care to combat chronic noncommunicable diseases (2011) (230)
Primary pancreatic beta-cell secretory defect caused by mutations in glucokinase gene in kindreds of maturity onset diabetes of the young (1992) (224)
Low copy number of the salivary amylase gene predisposes to obesity (2014) (224)
Genetics of obesity and the prediction of risk for health. (2006) (224)
A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance. (2006) (222)
Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders. (2018) (221)
Human glucokinase gene: isolation, characterization, and identification of two missense mutations linked to early-onset non-insulin-dependent (type 2) diabetes mellitus. (1992) (220)
Impaired hepatic glycogen synthesis in glucokinase-deficient (MODY-2) subjects. (1996) (219)
Array CGH analysis of copy number variation identifies 1284 new genes variant in healthy white males: implications for association studies of complex diseases. (2007) (218)
Integration of clinical data with a genome-scale metabolic model of the human adipocyte (2013) (216)
A gene for maturity onset diabetes of the young (MODY) maps to chromosome 12q (1995) (216)
Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity. (1995) (214)
Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population (2007) (213)
Predicting Diabetes: Clinical, Biological, and Genetic Approaches (2008) (213)
Glucokinase mutations associated with non-insulin-dependent (type 2) diabetes mellitus have decreased enzymatic activity: implications for structure/function relationships. (1993) (211)
Maternally inherited diabetes and deafness is a distinct subtype of diabetes and associates with a single point mutation in the mitochondrial tRNA Leu(UUR) gene (1994) (207)
Additive effect of A-->G (-3826) variant of the uncoupling protein gene and the Trp64Arg mutation of the beta 3-adrenergic receptor gene on weight gain in morbid obesity. (1996) (206)
Genetic evidence of assortative mating in humans (2017) (199)
Mutational analysis of melanocortin-4 receptor, agouti-related protein, and alpha-melanocyte-stimulating hormone genes in severely obese children. (2001) (199)
KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference (2016) (198)
Adiponectin gene polymorphisms and adiponectin levels are independently associated with the development of hyperglycemia during a 3-year period: the epidemiologic data on the insulin resistance syndrome prospective study. (2004) (198)
Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes (2011) (197)
Indication for Linkage of the Human OB Gene Region With Extreme Obesity (1996) (197)
HNF1α controls renal glucose reabsorption in mouse and man (2000) (191)
Genetic susceptibility for human familial essential hypertension in a region of homology with blood pressure linkage on rat chromosome 10. (1997) (191)
Kir6.2 mutations are a common cause of permanent neonatal diabetes in a large cohort of French patients. (2004) (189)
Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium. (2007) (189)
The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes (2000) (187)
Gene-Lifestyle Interaction and Type 2 Diabetes: The EPIC InterAct Case-Cohort Study (2014) (187)
Non-synonymous polymorphisms in melanocortin-4 receptor protect against obesity: the two facets of a Janus obesity gene. (2007) (183)
Dynamic hydroxymethylation of deoxyribonucleic acid marks differentiation-associated enhancers (2012) (178)
The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation (2015) (178)
Genome-wide association scans identified CTNNBL1 as a novel gene for obesity. (2008) (178)
Combined effects of MC4R and FTO common genetic variants on obesity in European general populations (2009) (176)
The Common P446L Polymorphism in GCKR Inversely Modulates Fasting Glucose and Triglyceride Levels and Reduces Type 2 Diabetes Risk in the DESIR Prospective General French Population (2008) (176)
A susceptibility locus for early-onset non-insulin dependent (type 2) diabetes mellitus maps to chromosome 20q, proximal to the phosphoenolpyruvate carboxykinase gene. (1997) (174)
A genetic variation in the 5 ′ flanking region of the UCP3 gene is associated with body mass index in humans in interaction with physical activity (2000) (173)
The FTO Gene Is Associated With Adulthood Obesity in the Mexican Population (2008) (171)
ACDC/adiponectin polymorphisms are associated with severe childhood and adult obesity. (2006) (170)
GAD2 on Chromosome 10p12 Is a Candidate Gene for Human Obesity (2003) (170)
A variation in the ghrelin gene increases weight and decreases insulin secretion in tall, obese children. (2002) (169)
Whole-Exome Sequencing and High Throughput Genotyping Identified KCNJ11 as the Thirteenth MODY Gene (2012) (168)
A missense mutation in the glucagon receptor gene is associated with non–insulin–dependent diabetes mellitus (1995) (168)
Monogenic diabetes in the young, pharmacogenetics and relevance to multifactorial forms of type 2 diabetes. (2008) (167)
Cloning, Functional Expression, and Chromosomal Localization of the Human Pancreatic Islet Glucose-Dependent Insulinotropic Polypeptide Receptor (1995) (166)
Impact of Common Type 2 Diabetes Risk Polymorphisms in the DESIR Prospective Study (2008) (164)
Meta‐Analysis of Genome‐wide Linkage Studies in BMI and Obesity (2007) (159)
A Central Role for GRB10 in Regulation of Islet Function in Man (2014) (159)
Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma (2012) (159)
Identification of nine novel mutations in the hepatocyte nuclear factor 1 alpha gene associated with maturity-onset diabetes of the young (MODY3). (1997) (157)
Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis (2017) (156)
Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults (2017) (153)
A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population (2007) (153)
The emerging genetics of type 2 diabetes. (2010) (151)
The Trans-Ancestral Genomic Architecture of Glycemic Traits (2020) (151)
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits (2017) (149)
Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study (2011) (148)
A genome-wide scan for childhood obesity-associated traits in French families shows significant linkage on chromosome 6q22.31-q23.2. (2004) (148)
Post Genome-Wide Association Studies of Novel Genes Associated with Type 2 Diabetes Show Gene-Gene Interaction and High Predictive Value (2008) (148)
Genetic, metabolic and clinical characteristics of maturity onset diabetes of the young. (1998) (147)
Promoter polymorphism T(-107)C of the paraoxonase PON1 gene is a risk factor for coronary heart disease in type 2 diabetic patients. (2000) (145)
Dual roles of adiponectin/Acrp30 in vivo as an anti-diabetic and anti-atherogenic adipokine. (2003) (145)
Directional dominance on stature and cognition in diverse human populations (2015) (144)
Mutation screening in 18 Caucasian families suggest the existence of other MODY genes (1998) (139)
A polymorphism in the 5′ untranslated region of the human ob gene is associated with low leptin levels (1998) (139)
The Pro115Gln and Pro12Ala PPAR gamma gene mutations in obesity and type 2 diabetes (2000) (138)
G-allele of Intronic rs10830963 in MTNR1B Confers Increased Risk of Impaired Fasting Glycemia and Type 2 Diabetes Through an Impaired Glucose-Stimulated Insulin Release (2009) (136)
Hypoadiponectinaemia and high risk of type 2 diabetes are associated with adiponectin-encoding (ACDC) gene promoter variants in morbid obesity: evidence for a role of ACDC in diabesity (2005) (135)
Childhood Obesity Is Associated with Shorter Leukocyte Telomere Length (2011) (134)
The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies (2008) (132)
Rare and common genetic events in type 2 diabetes: what should biologists know? (2015) (132)
Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes (2012) (129)
Insulin Gene Mutations Resulting in Early-Onset Diabetes: Marked Differences in Clinical Presentation, Metabolic Status, and Pathogenic Effect Through Endoplasmic Reticulum Retention (2009) (128)
Molecular Diagnosis of Neonatal Diabetes Mellitus Using Next-Generation Sequencing of the Whole Exome (2010) (127)
Heterozygous Missense Mutations in the Insulin Gene Are Linked to Permanent Diabetes Appearing in the Neonatal Period or in Early Infancy (2008) (127)
beta-cell genes and diabetes: quantitative and qualitative differences in the pathophysiology of hepatic nuclear factor-1alpha and glucokinase mutations. (2001) (127)
A missense mutation in hepatocyte nuclear factor-4 alpha, resulting in a reduced transactivation activity, in human late-onset non-insulin-dependent diabetes mellitus. (1998) (123)
Shared genetic predisposition in rheumatoid arthritis-interstitial lung disease and familial pulmonary fibrosis (2017) (123)
Clinical Phenotypes, Insulin Secretion, and Insulin Sensitivity in Kindreds With Maternally Inherited Diabetes and Deafness Due to Mitochondrial tRNALeu(UUR) Gene Mutation (1996) (123)
Inflammation is associated with a decrease of lipogenic factors in omental fat in women. (2008) (121)
Implication of the Pro12Ala polymorphism of the PPAR-gamma 2 gene in type 2 diabetes and obesity in the French population (2005) (120)
Leveraging Cross-Species Transcription Factor Binding Site Patterns: From Diabetes Risk Loci to Disease Mechanisms (2014) (120)
The genetics of adiponectin (2003) (119)
From obesity genetics to the future of personalized obesity therapy (2013) (115)
Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes (2017) (114)
Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03). (2009) (113)
Estimation of Newborn Risk for Child or Adolescent Obesity: Lessons from Longitudinal Birth Cohorts (2012) (111)
Prevalence of Loss-of-Function FTO Mutations in Lean and Obese Individuals (2009) (110)
TCF7L2 Variation Predicts Hyperglycemia Incidence in a French General Population (2006) (109)
Diabetes Complications in NIDDM Kindreds Linked to the MODY3 Locus on Chromosome 12q (1996) (109)
SREBF-1 gene polymorphisms are associated with obesity and type 2 diabetes in French obese and diabetic cohorts. (2004) (108)
Molecular Genetics of Human Obesity‐Associated MC4R Mutations (2003) (106)
Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body mass index in European populations. (2008) (106)
Common genetic variation near MC4R is associated with eating behaviour patterns in European populations (2009) (105)
A large multi-centre European study validates high-sensitivity C-reactive protein (hsCRP) as a clinical biomarker for the diagnosis of diabetes subtypes (2011) (105)
MODY7 Gene, KLF11, Is a Novel p300-dependent Regulator of Pdx-1 (MODY4) Transcription in Pancreatic Islet β Cells* (2009) (104)
Genetic and clinical characterisation of maturity-onset diabetes of the young in Spanish families. (2000) (104)
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution (2011) (104)
Common Genetic Variation Near Melatonin Receptor MTNR1B Contributes to Raised Plasma Glucose and Increased Risk of Type 2 Diabetes Among Indian Asians and European Caucasians (2009) (103)
Association of Genetic Loci With Glucose Levels in Childhood and Adolescence (2011) (103)
Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity (2007) (103)
Prevalence of macular pattern dystrophy in maternally inherited diabetes and deafness. GEDIAM Group. (1999) (103)
The adiponectin gene SNP+45 is associated with coronary artery disease in Type 2 (non‐insulin‐dependent) diabetes mellitus (2004) (102)
Genetic approaches to the molecular understanding of type 2 diabetes. (2002) (102)
Genetic Studies of the Sulfonylurea Receptor Gene Locus in NIDDM and in Morbid Obesity Among French Caucasians (1997) (101)
A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. (2018) (100)
Genome-Wide Search for Type 2 Diabetes in Japanese Affected Sib-Pairs Confirms Susceptibility Genes on 3 q , 15 q , and 20 q and Identifies Two New Candidate Loci on 7 p and 11 p (2002) (100)
Loss-of-function mutations in ADCY3 cause monogenic severe obesity (2018) (99)
Heterozygous Mutations Causing Partial Prohormone Convertase 1 Deficiency Contribute to Human Obesity (2012) (99)
Loss-of-function mutations in SIM1 contribute to obesity and Prader-Willi-like features. (2013) (99)
Adiponectin, type 2 diabetes and the metabolic syndrome: lessons from human genetic studies (2006) (96)
Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations (2012) (96)
R125W coding variant in TBC1D1 confers risk for familial obesity and contributes to linkage on chromosome 4p14 in the French population. (2008) (94)
Evidence of a non-MHC susceptibility locus in type I diabetes linked to HLA on chromosome 6. (1997) (94)
Tryptophan metabolism activation by indoleamine 2,3-dioxygenase in adipose tissue of obese women: an attempt to maintain immune homeostasis and vascular tone. (2012) (94)
A synonymous coding polymorphism in the alpha2-Heremans-schmid glycoprotein gene is associated with type 2 diabetes in French Caucasians. (2005) (93)
Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids (2019) (93)
Effects of TCF7L2 Polymorphisms on Obesity in European Populations (2008) (93)
Anatomy of a Homeoprotein Revealed by the Analysis of Human MODY3 Mutations* (1999) (92)
Association between large detectable clonal mosaicism and type 2 diabetes with vascular complications (2013) (92)
Genetic association analyses highlight biological pathways underlying mitral valve prolapse (2015) (92)
Polymorphisms in the amino acid transporter solute carrier family 6 (neurotransmitter transporter) member 14 gene contribute to polygenic obesity in French Caucasians. (2004) (92)
Multiple-cohort genetic association study reveals CXCR6 as a new chemokine receptor involved in long-term nonprogression to AIDS. (2010) (91)
Common Polymorphisms in the Adiponectin Gene ACDC Are Not Associated With Diabetes in Pima Indians. (2005) (90)
From obesity genetics to the future of personalized obesity therapy (2014) (90)
Beneficial effect of a high number of copies of salivary amylase AMY1 gene on obesity risk in Mexican children (2015) (89)
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation (2020) (88)
Genetic determinants of type 2 diabetes. (2001) (87)
First Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes (2018) (87)
Mutation screening of the PPARalpha gene in type 2 diabetes associated with coronary heart disease. (2000) (87)
Identification of susceptibility genes for complex diseases using pooling-based genome-wide association scans (2009) (87)
Adipose Tissue Resting Energy Expenditure and Expression of Genes Involved in Mitochondrial Function Are Higher in Women than in Men (2012) (86)
Comment on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity" (2007) (86)
Meta-Analysis of the INSIG2 Association with Obesity Including 74,345 Individuals: Does Heterogeneity of Estimates Relate to Study Design? (2009) (85)
KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron (2012) (84)
Linkage Analysis and Molecular Scanning of Glucokinase Gene in NIDDM Families (1993) (84)
Association of the calpain-10 gene with type 2 diabetes in Europeans: results of pooled and meta-analyses. (2006) (83)
HNF1alpha controls renal glucose reabsorption in mouse and man. (2000) (83)
Genetic basis of maturity-onset diabetes of the young. (2006) (82)
Bardet-Biedl Syndrome Gene Variants Are Associated With Both Childhood and Adult Common Obesity in French Caucasians (2006) (82)
Genome-wide linkage analysis for severe obesity in french caucasians finds significant susceptibility locus on chromosome 19q. (2004) (82)
Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study (2008) (82)
An uncoupling protein 3 gene polymorphism associated with a lower risk of developing Type II diabetes and with atherogenic lipid profile in a French cohort (2000) (82)
A meta-analysis of four European genome screens (GIFT Consortium) shows evidence for a novel region on chromosome 17p11.2-q22 linked to type 2 diabetes. (2003) (82)
Association of Sirtuin 1 (SIRT1) Gene SNPs and Transcript Expression Levels With Severe Obesity (2012) (82)
Early metabolic markers identify potential targets for the prevention of type 2 diabetes (2017) (81)
Genetic Polymorphisms and Weight Loss in Obesity: A Randomised Trial of Hypo-Energetic High- versus Low-Fat Diets (2006) (81)
Soluble leptin receptor in serum of subjects with complete resistance to leptin: relation to fat mass. (2000) (81)
Maternal diabetes alters birth weight in glucokinase-deficient (MODY2) kindred but has no influence on adult weight, height, insulin secretion or insulin sensitivity (2000) (80)
Neuropsychological dysfunction and developmental defects associated with genetic changes in infants with neonatal diabetes mellitus: a prospective cohort study [corrected]. (2013) (80)
Inflammatory Role of Toll-Like Receptors in Human and Murine Adipose Tissue (2010) (80)
Cloning and Characterization of the Human and Rat Islet-specific Glucose-6-phosphatase Catalytic Subunit-related Protein (IGRP) Genes* (2001) (79)
Human genes involved in copy number variation: mechanisms of origin, functional effects and implications for disease (2009) (79)
Contribution of type 2 diabetes associated loci in the Arabic population from Tunisia: a case-control study (2009) (78)
Fine chromosome mapping of the genes for human liver and muscle carnitine palmitoyltransferase I (CPT1A and CPT1B). (1997) (78)
No association between the G482S polymorphism of the proliferator-activated receptor-gamma coactivator-1 (PGC-1) gene and Type II diabetes in French Caucasians. (2002) (78)
Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations (2008) (78)
The G-allele of intronic rs 10830963 in MTNR 1 B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release : studies involving 19 , 605 Europeans (2009) (77)
Association Studies on Ghrelin and Ghrelin Receptor Gene Polymorphisms With Obesity (2009) (77)
TCF7L2 genetic defect and type 2 diabetes (2008) (77)
Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions. (2019) (77)
Genetic analysis of ADIPOR1 and ADIPOR2 candidate polymorphisms for type 2 diabetes in the Caucasian population. (2006) (77)
Long-Term Follow-Up of Oral Glucose Tolerance Test–Derived Glucose Tolerance and Insulin Secretion and Insulin Sensitivity Indexes in Subjects With Glucokinase Mutations (MODY2) (2008) (77)
Rapid SNP allele frequency determination in genomic DNA pools by pyrosequencing. (2002) (76)
DNA Damage and the Activation of the p53 Pathway Mediate Alterations in Metabolic and Secretory Functions of Adipocytes (2016) (76)
New ABCC8 Mutations in Relapsing Neonatal Diabetes and Clinical Features (2007) (76)
Highly Sensitive Diagnosis of 43 Monogenic Forms of Diabetes or Obesity Through One-Step PCR-Based Enrichment in Combination With Next-Generation Sequencing (2014) (76)
Genetic variants in LEP, LEPR, and MC4R explain 30% of severe obesity in children from a consanguineous population (2015) (76)
Genetics of Pathways Regulating Body Weight in the Development of Obesity in Humans (2001) (75)
Genetics of the APM1 locus and its contribution to type 2 diabetes susceptibility in French Caucasians. (2004) (74)
Molecular Genetics of Maturity-onset Diabetes of the Young (1999) (74)
TCF7L2 splice variants have distinct effects on beta-cell turnover and function. (2011) (74)
Is obesity our genetic legacy? (2008) (74)
Meta-analysis and functional effects of the SLC30A8 rs13266634 polymorphism on isolated human pancreatic islets. (2010) (73)
Endoplasmic Reticulum Stress Links Oxidative Stress to Impaired Pancreatic Beta-Cell Function Caused by Human Oxidized LDL (2016) (72)
Prevalence of mitochondrial gene mutations in families with diabetes mellitus (1993) (72)
A CD36 nonsense mutation associated with insulin resistance and familial type 2 diabetes (2004) (71)
Preadipocyte response and impairment of differentiation in an inflammatory environment. (2007) (71)
Mutation screening of the human UCP 2 gene in normoglycemic and NIDDM morbidly obese patients: lack of association between new UCP 2 polymorphisms and obesity in French Caucasians. (1998) (71)
A genome-wide scan in families with maturity-onset diabetes of the young: evidence for further genetic heterogeneity. (2003) (71)
Insulin receptor substrate (IRS-1) gene polymorphisms in French NIDDM families (1993) (70)
A Rare Variant in the Visfatin Gene (NAMPT/PBEF1) Is Associated With Protection From Obesity (2009) (70)
High prevalence of leptin and melanocortin-4 receptor gene mutations in children with severe obesity from Pakistani consanguineous families. (2012) (70)
Disruption of a Novel Krüppel-like Transcription Factor p300-regulated Pathway for Insulin Biosynthesis Revealed by Studies of the c.-331 INS Mutation Found in Neonatal Diabetes Mellitus* (2011) (69)
Candidate gene approach of familial morbid obesity: linkage analysis of the glucocorticoid receptor gene. (1996) (69)
ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic disease (2009) (68)
European genetic variants associated with type 2 diabetes in North African Arabs. (2012) (68)
GUESS-ing Polygenic Associations with Multiple Phenotypes Using a GPU-Based Evolutionary Stochastic Search Algorithm (2013) (68)
Alcohol consumption and risk of type 2 diabetes in European men and women: influence of beverage type and body sizeThe EPIC–InterAct study (2012) (67)
Type 2 diabetes mellitus: association study of five candidate genes in an Indian population of Guadeloupe, genetic contribution of FABP2 polymorphism. (1999) (67)
The Imprinted Gene Neuronatin Is Regulated by Metabolic Status and Associated With Obesity (2010) (66)
PAI-1 polymorphisms modulate phenotypes associated with the metabolic syndrome in obese and diabetic Caucasian population (2003) (66)
Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity (2019) (65)
Association of poorly controlled diabetes with low serum leptin in morbid obesity (1997) (64)
Small Deletion Variants Have Stable Breakpoints Commonly Associated with Alu Elements (2008) (64)
RFX6 regulates insulin secretion by modulating Ca2+ homeostasis in human β cells. (2014) (64)
Analysis of the contribution of FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4R genes to obesity in Mexican children (2013) (63)
A Rare Mutation in ABCC8/SUR1 Leading to Altered ATP-Sensitive K+ Channel Activity and β-Cell Glucose Sensing Is Associated With Type 2 Diabetes in Adults (2008) (63)
TCF7L2 rs7903146 impairs islet function and morphology in non-diabetic individuals (2012) (63)
Regulation of carboxylesterase 1 (CES1) in human adipose tissue (2009) (62)
Expression of the selenoprotein S (SELS) gene in subcutaneous adipose tissue and SELS genotype are associated with metabolic risk factors (2011) (61)
Compensation in Pancreatic β-Cell Function in Subjects With Glucokinase Mutations (1994) (60)
Lipoprotein(a) in Diabetic Patients and Normoglycemic Relatives in Familial NIDDM (1993) (60)
Multiple DNA variant association analysis: application to the insulin gene region in type I diabetes. (1994) (59)
Direct estimates of natural selection in Iberia indicate calcium absorption was not the only driver of lactase persistence in Europe. (2014) (59)
Predicting Diabetes: Clinical, Biological, and Genetic Approaches Data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR) (2008) (59)
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability (2020) (58)
GATA6 inactivating mutations are associated with heart defects and, inconsistently, with pancreatic agenesis and diabetes (2012) (58)
The lessons of early-onset monogenic diabetes for the understanding of diabetes pathogenesis. (2012) (58)
Analysis of common PTPN1 gene variants in type 2 diabetes, obesity and associated phenotypes in the French population (2006) (57)
Contribution of 24 obesity-associated genetic variants to insulin resistance, pancreatic beta-cell function and type 2 diabetes risk in the French population (2013) (57)
Naturally occurring mutations in the melanocortin receptor 3 gene are not associated with type 2 diabetes mellitus in French Caucasians. (2001) (57)
Six Mutations in the Glucokinase Gene Identified in MODY by Using a Nonradioactive Sensitive Screening Technique (1994) (57)
Genetics of NIDDM in France: Studies With 19 Candidate Genes in Affected Sib Pairs (1997) (57)
ACDC/Adiponectin and PPAR‐γ Gene Polymorphisms: Implications for Features of Obesity (2005) (57)
Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice (2017) (56)
TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet. (2010) (56)
ENPP1 K121Q polymorphism and obesity, hyperglycaemia and type 2 diabetes in the prospective DESIR Study (2007) (56)
Genetic study of the CD36 gene in a French diabetic population. (2004) (56)
Obesity‐related Polymorphisms and Their Associations With the Ability to Regulate Fat Oxidation in Obese Europeans: The NUGENOB Study (2010) (56)
Does the −11377 promoter variant of APM1 gene contribute to the genetic risk for Type 2 diabetes mellitus in Japanese families? (2003) (56)
Linkage and association studies between the proopiomelanocortin (POMC) gene and obesity in caucasian families (2000) (56)
Common Variants in FTO, MC4R, TMEM18, PRL, AIF1, and PCSK1 Show Evidence of Association With Adult Obesity in the Greek Population (2012) (56)
Is glutamate decarboxylase 2 (GAD2) a genetic link between low birth weight and subsequent development of obesity in children? (2005) (55)
Higher Maternal Than Paternal Inheritance of Diabetes in GK Rats (1994) (55)
Investigation of Mendelian forms of obesity holds out the prospect of personalized medicine (2010) (55)
Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits (2020) (55)
A nonsense loss-of-function mutation in PCSK1 contributes to dominantly inherited human obesity (2014) (55)
Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps (2018) (55)
Low-dose exposure to bisphenols A, F and S of human primary adipocyte impacts coding and non-coding RNA profiles (2017) (55)
Study of TNFalpha -308G/A and IL6 -174G/C polymorphisms in type 2 diabetes and obesity risk in the Tunisian population. (2010) (55)
A sib-pair analysis study of 15 candidate genes in French families with morbid obesity: indication for linkage with islet 1 locus on chromosome 5q. (1999) (54)
Novel LEPR mutations in obese Pakistani children identified by PCR‐based enrichment and next generation sequencing (2014) (54)
Structure/function studies of human beta-cell glucokinase. Enzymatic properties of a sequence polymorphism, mutations associated with diabetes, and other site-directed mutants. (1993) (53)
Leptin Receptor Genotype at Gln223Arg is Associated With Body Composition, BMD, and Vertebral Fracture in Postmenopausal Danish Women (2007) (53)
Missense mutation Gly574Ser in the transcription factor HNF-1alpha is a marker of atypical diabetes mellitus in African-American children. (1999) (53)
Dietary fat intake and polymorphisms at the PPARG locus modulate BMI and type 2 diabetes risk in the D.E.S.I.R. prospective study (2012) (53)
Genetic studies of the leptin receptor gene in morbidly obese French Caucasian families (1997) (53)
Assessment of insulin sensitivity in glucokinase-deficient subjects (1996) (52)
Missense mutations in the TGM2 gene encoding transglutaminase 2 are found in patients with early‐onset type 2 diabetes (2007) (52)
Variation Within the Gene Encoding the Upstream Stimulatory Factor 1 Does Not Influence Susceptibility to Type 2 Diabetes in Samples From Populations With Replicated Evidence of Linkage to Chromosome 1q (2006) (52)
Hepatic DPP4 DNA Methylation Associates With Fatty Liver (2016) (52)
Beneficial Metabolic Effects of Rapamycin Are Associated with Enhanced Regulatory Cells in Diet-Induced Obese Mice (2014) (52)
Clinical Heterogeneity in Monogenic Diabetes Caused by Mutations in the Glucokinase Gene (GCK-MODY) (2009) (51)
The loss-of-function PCSK9 p.R46L genetic variant does not alter glucose homeostasis (2015) (51)
A Trans-ancestral Meta-Analysis of Genome-Wide Association Studies Reveals Loci Associated with Childhood Obesity. (2019) (51)
Mutation screening and association studies of the human uncoupling protein 3 gene in normoglycemic and diabetic morbidly obese patients. (1999) (50)
Common Variation in SIM1 Is Reproducibly Associated With BMI in Pi ma Indians (2009) (50)
cnvHap: an integrative population and haplotype–based multiplatform model of SNPs and CNVs (2010) (50)
A genome-wide scan for coronary heart disease suggests in Indo-Mauritians a susceptibility locus on chromosome 16 p 13 and replicates linkage with the metabolic syndrome on 3 q 27 (2001) (50)
Genotype-by-nutrient interactions assessed in European obese women (2006) (49)
Transcription factor gene MNX1 is a novel cause of permanent neonatal diabetes in a consanguineous family. (2013) (49)
Pluripotent Stem Cells as a Potential Tool for Disease Modelling and Cell Therapy in Diabetes (2014) (48)
The Gly40Ser Mutation in the Human Glucagon Receptor Gene Associated With NIDDM Results in a Receptor With Reduced Sensitivity to Glucagon (1996) (48)
Analysis of sequence variability in the CART gene in relation to obesity in a Caucasian population (2005) (48)
Tenomodulin is highly expressed in adipose tissue, increased in obesity, and down-regulated during diet-induced weight loss. (2009) (48)
Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity-Associated Type 2 Diabetes (2017) (48)
Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion (2017) (47)
Association between high von Willebrand factor levels and the Thr789Ala vWF gene polymorphism but not with nephropathy in type I diabetes (2000) (47)
Are animal models of diabetes relevant to the study of the genetics of non-insulin-dependent diabetes in humans? (1997) (47)
Genetic studies of polymorphisms in ten non-insulin-dependent diabetes mellitus candidate genes in Tamil Indians from Pondichery. (1998) (47)
MTNR1B G24E Variant Associates With BMI and Fasting Plasma Glucose in the General Population in Studies of 22,142 Europeans (2010) (47)
Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations (2008) (46)
Association of gene variants with susceptibility to type 2 diabetes among Omanis. (2015) (46)
Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes. (2020) (46)
Association of elevated lipoprotein(a) levels and coronary heart disease in NIDDM patients. Relationship with apolipoprotein(a) phenotypes (1994) (45)
What Is the Contribution of Two Genetic Variants Regulating VEGF Levels to Type 2 Diabetes Risk and to Microvascular Complications? (2013) (45)
Polymorphism of the glycogen synthase gene and non-insulin-dependent diabetes mellitus. (1993) (45)
Evaluation of A2BP1 as an Obesity Gene (2010) (44)
Endospanins Regulate a Postinternalization Step of the Leptin Receptor Endocytic Pathway* (2011) (44)
Several obesity- and nutrient-related gene polymorphisms but not FTO and UCP variants modulate postabsorptive resting energy expenditure and fat-induced thermogenesis in obese individuals: the NUGENOB Study (2009) (43)
Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes (2005) (43)
A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk (2017) (43)
Amino acid exchange between plasma and erythrocytes in vivo in humans. (1989) (43)
Lack of association between the Pro12Ala polymorphism of the PPAR-γ2 gene and type 2 diabetes mellitus in the Qatari consanguineous population (2008) (42)
Search for a Third Susceptibility Gene for Maturity-Onset Diabetes of the Young: Studies With Eleven Candidate Genes (1994) (42)
Type 2 diabetes-related genetic risk scores associated with variations in fasting plasma glucose and development of impaired glucose homeostasis in the prospective DESIR study (2014) (42)
Clinical and Metabolic Features of Adult-Onset Diabetes Caused by ABCC8 Mutations (2012) (42)
Type 2 diabetes–associated variants of the MT2 melatonin receptor affect distinct modes of signaling (2018) (42)
Relationship between salivary/pancreatic amylase and body mass index: a systems biology approach (2017) (42)
Common Genetic Variants and Risk of Brain Injury After Preterm Birth (2014) (42)
Improved donor/acceptor BRET couples for monitoring β‐arrestin recruitment to G protein‐coupled receptors (2009) (41)
Routine mutation screening of HNF-1α and GCK genes in MODY diagnosis: How effective are the techniques of DHPLC and direct sequencing used in combination? (2001) (41)
Preferential reciprocal transfer of paternal/maternal DLK1 alleles to obese children: first evidence of polar overdominance in humans (2008) (41)
A Genome-Wide Association Study Identifies rs2000999 as a Strong Genetic Determinant of Circulating Haptoglobin Levels (2012) (40)
Insulin secretion and insulin sensitivity in diabetic and non-diabetic subjects with hepatic nuclear factor-1alpha (maturity-onset diabetes of the young-3) mutations. (1999) (40)
Epigenome-wide association study of adiposity and future risk of obesity-related diseases (2018) (40)
MFN2-associated lipomatosis: Clinical spectrum and impact on adipose tissue. (2018) (40)
Eating Behavior, Low-Frequency Functional Mutations in the Melanocortin-4 Receptor (MC4R) Gene, and Outcomes of Bariatric Operations: A 6-Year Prospective Study (2016) (40)
Free fatty acids and insulin levels—relationship to leptin levels and body composition in various patient groups from South Africa (1999) (38)
Strategies for calibrating a subcutaneous glucose sensor. (1989) (38)
Loss-of-function mutations in MRAP2 are pathogenic in hyperphagic obesity with hyperglycemia and hypertension (2019) (38)
Activating Transcription Factor 6 (ATF6) Sequence Polymorphisms in Type 2 Diabetes and Pre-Diabetic Traits (2007) (37)
Single nucleotide polymorphisms of protein tyrosine phosphatase 1B gene are associated with obesity in morbidly obese French subjects (2004) (37)
Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study (2016) (37)
Hepatocyte Nuclear Factor-4α P2 Promoter Haplotypes Are Associated With Type 2 Diabetes in the Japanese Population (2006) (37)
Association of melanin-concentrating hormone receptor 1 5' polymorphism with early-onset extreme obesity. (2005) (37)
Peroxisome Proliferator-activated Receptor γ Regulates Genes Involved in Insulin/Insulin-like Growth Factor Signaling and Lipid Metabolism during Adipogenesis through Functionally Distinct Enhancer Classes* (2013) (36)
Effect of common polymorphisms in the HNF4α promoter on susceptibility to type 2 diabetes in the French Caucasian population (2005) (36)
Strong association of common variants in the CDKN2A/CDKN2B region with type 2 diabetes in French Europids (2008) (36)
Genetic studies of neuropeptide Y and neuropeptide Y receptors Y1 and Y5 regions in morbid obesity (1997) (36)
Islet-brain1/C-Jun N-terminal kinase interacting protein-1 (IB1/JIP-1) promoter variant is associated with Alzheimer's disease (2003) (36)
Coffee and tea consumption, genotype‐based CYP1A2 and NAT2 activity and colorectal cancer risk—Results from the EPIC cohort study (2014) (36)
Screening Low-Frequency SNPS From Genome-Wide Association Study Reveals a New Risk Allele for Progression to AIDS (2011) (36)
No evidence of linkage or diabetes-associated mutations in the transcription factors BETA2/NEUROD1 and PAX4 in Type II diabetes in France (1999) (36)
Inferring combined CNV/SNP haplotypes from genotype data (2010) (35)
Are C-Reactive Protein Associated Genetic Variants Associated with Serum Levels and Retinal Markers of Microvascular Pathology in Asian Populations from Singapore? (2013) (35)
Genetic Variant in HK1 Is Associated With a Proanemic State and A1C but Not Other Glycemic Control–Related Traits (2009) (35)
Polymorphism analysis of JRK/JH8, the human homologue of mouse jerky, and description of a rare mutation in a case of CAE evolving to JME (2001) (35)
Role of the Unfolded Protein Response in β Cell Compensation and Failure during Diabetes (2014) (35)
Identification of seven novel nucleotide variants in the hepatocyte nuclear factor‐1α (TCF1) promoter region in MODY patients (2000) (35)
Estrogen receptor alpha gene variants associate with type 2 diabetes and fasting plasma glucose (2008) (35)
Genetic, pharmacological and functional analysis of cholecystokinin-1 and cholecystokinin-2 receptor polymorphism in type 2 diabetes and obese patients. (2002) (35)
In vivo calibration of a subcutaneous glucose sensor for determination of subcutaneous glucose kinetics (1988) (35)
Genetics of human obesity. (2001) (34)
The T-381C SNP in BNP gene may be modestly associated with type 2 diabetes: an updated meta-analysis in 49 279 subjects. (2009) (34)
Study and development of multilayer needle-type enzyme-based glucose microsensors. (1989) (34)
Evaluation of the Association of IGF2BP2 Variants With Type 2 Diabetes in French Caucasians (2008) (34)
Maturity-onset diabetes of the young (MODY), MODY genes and non-insulin-dependent diabetes mellitus. (1997) (34)
Effect of ENPP1/PC-1-K121Q and PPARgamma-Pro12Ala polymorphisms on the genetic susceptibility to T2D in the Tunisian population. (2008) (34)
Novel association approach for variable number tandem repeats (VNTRs) identifies DOCK5 as a susceptibility gene for severe obesity. (2012) (34)
ACDC/adiponectin and PPAR-gamma gene polymorphisms: implications for features of obesity. (2005) (34)
Common Variation in the LMNA Gene (Encoding Lamin A/C) and Type 2 Diabetes (2007) (34)
Rare Genomic Structural Variants in Complex Disease: Lessons from the Replication of Associations with Obesity (2013) (34)
Monogenic diabetes: Implementation of translational genomic research towards precision medicine (2016) (34)
The role of ghrelin and ghrelin-receptor gene variants and promoter activity in type 2 diabetes. (2009) (34)
Single nucleotide polymorphisms in the neuropeptide Y2 receptor (NPY2R) gene and association with severe obesity in French white subjects (2007) (33)
Genetic and Functional Assessment of the Role of the rs13431652-A and rs573225-A Alleles in the G6PC2 Promoter That Are Strongly Associated With Elevated Fasting Glucose Levels (2010) (33)
Reassessment of the putative role of BLK-p.A71T loss-of-function mutation in MODY and type 2 diabetes (2013) (33)
Common polymorphisms in the USF1 gene are not associated with type 2 diabetes in French Caucasians. (2005) (33)
Genetics of Obesity in Consanguineous Populations: Toward Precision Medicine and the Discovery of Novel Obesity Genes (2018) (33)
Alternative human liver transcripts of TCF7L2 bind to the gluconeogenesis regulator HNF4α at the protein level (2014) (32)
Functional and genetic analysis in type 2 diabetes of Liver X receptor alleles – a cohort study (2009) (32)
- Cell Genes and Diabetes : Quantitative and Qualitative Differences in the Pathophysiology of Hepatic Nuclear Factor-1 and Glucokinase Mutations (2001) (32)
Diagnostic Heterogeneity of Diabetes in Lean Young Adults: Classification Based on Immunological and Genetic Parameters (1997) (31)
The power of the extreme in elucidating obesity. (2008) (31)
Insulin promoter factor 1 gene is not a major cause of maturity-onset diabetes of the young in French Caucasians. (1998) (31)
Erratum: Human glucokinase gene: Isolation, characterization, and identification of two missense mutations linked to early-onset non-insulin- dependent (type 2) diabetes mellitus (Proc. Natl. Acad. Sci. USA (August 15, 1992) 89 (7698-7702)) (1992) (31)
Interleukin-7 Regulates Adipose Tissue Mass and Insulin Sensitivity in High-Fat Diet-Fed Mice through Lymphocyte-Dependent and Independent Mechanisms (2012) (31)
The TGR5 gene is expressed in human subcutaneous adipose tissue and is associated with obesity, weight loss and resting metabolic rate (2013) (31)
Mutations in the glucokinase regulatory protein gene in 2p23 in obese French caucasians (2003) (30)
Fine-scale human genetic structure in Western France (2014) (30)
Identification of a Variable Number of Tandem Repeats Polymorphism and Characterization of LEF-1 Response Elements in the Promoter of the IDO1 Gene (2011) (30)
Multiple functional polymorphisms in the G6PC2 gene contribute to the association with higher fasting plasma glucose levels (2013) (30)
Comment On: Valette et al. Melanocortin-4 Receptor Mutations and Polymorphisms Do Not Affect Weight Loss after Bariatric Surgery. PLOS ONE 2012; 7(11):E48221 (2014) (30)
Evidence for leptin receptor isoforms heteromerization at the cell surface (2010) (29)
Meal Frequencies Modify the Effect of Common Genetic Variants on Body Mass Index in Adolescents of the Northern Finland Birth Cohort 1986 (2013) (29)
No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels (2012) (29)
Linkage Analyses of the MODY3 Locus on Chromosome 12q With Late-Onset NIDDM (1995) (29)
Cdkn2a deficiency promotes adipose tissue browning (2017) (29)
Genetic Association Analyses Highlight IL6, ALPL, and NAV1 As 3 New Susceptibility Genes Underlying Calcific Aortic Valve Stenosis. (2019) (29)
Glucokinase gene mutations are not a common cause of permanent neonatal diabetes in France (2002) (29)
Mapping NIDDM Susceptibility Loci in French Families: Studies With Markers in the Region of NIDDM1 on Chromosome 2q (1997) (29)
Association of the ENPP1 K121Q polymorphism with type 2 diabetes and obesity in the Moroccan population. (2009) (29)
Genetic determinants of non-insulin-dependent diabetes mellitus: strategies and recent results. (1997) (29)
A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure. (2019) (28)
Linkage Disequilibrium Mapping of the Replicated Type 2 Diabetes Linkage Signal on Chromosome 1q (2009) (28)
Genetic study of the melanin-concentrating hormone receptor 2 in childhood and adulthood severe obesity. (2007) (28)
Impact of Common Variation in Bone-Related Genes on Type 2 Diabetes and Related Traits (2012) (28)
In vivo calibration of a subcutaneous sensor for determination of subcutaneous glucose kinetics (1988) (27)
Leptin receptor gene in a large cohort of massively obese subjects: no indication of the fa/fa rat mutation. Detection of an intronic variant with no association with obesity. (1998) (27)
Glucose utilization and production in patients with maturity-onset diabetes of the young caused by a mutation of the hepatocyte nuclear factor-1alpha gene. (1998) (27)
Distinct impaired regulation of SOCS3 and long and short isoforms of the leptin receptor in visceral and subcutaneous fat of lean and obese women. (2006) (27)
The (Ala-Val) mutation of methylenetetrahydrofolate reductase as a genetic risk factor for vascular disease in non-insulin-dependent diabetic patients. (1997) (27)
Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium (2019) (26)
Bardet-Biedl Syndrome Gene Variants Are Associated With Both Childhood and Adult Common Obesity in (2006) (26)
Differential co-expression analysis of obesity-associated networks in human subcutaneous adipose tissue (2011) (26)
Improved protocol for laser microdissection of human pancreatic islets from surgical specimens. (2013) (26)
Maturity Onset Diabetes of the Young Type 2 (2004) (26)
Pathogenic variants in actionable MODY genes are associated with type 2 diabetes (2020) (26)
Contribution of the low-frequency, loss-of-function p.R270H mutation in FFAR4 (GPR120) to increased fasting plasma glucose levels (2015) (26)
Multicohort genomewide association study reveals a new signal of protection against HIV-1 acquisition. (2012) (26)
Mechanisms behind the immediate effects of Roux-en-Y gastric bypass surgery on type 2 diabetes (2013) (26)
Indication for genetic linkage of the phosphoenolpyruvate carboxykinase (PCK1) gene region on chromosome 20q to non-insulin-dependent diabetes mellitus. (1996) (26)
Identification of a locus for nongoitrous congenital hypothyroidism on chromosome 15q25.3-26.1 (2005) (25)
Human Mutation within Per-Arnt-Sim (PAS) Domain-containing Protein Kinase (PASK) Causes Basal Insulin Hypersecretion* (2011) (25)
Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9 (2018) (25)
ITIH‐5 Expression in Human Adipose Tissue Is Increased in Obesity (2012) (25)
Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults (2018) (25)
Neonatal hyperglycaemia and abnormal development of the pancreas. (2008) (25)
Sequence data and association statistics from 12,940 type 2 diabetes cases and controls (2017) (25)
Polymorphisms in the Glucokinase-Associated, Dual-Specificity Phosphatase 12 (DUSP12) Gene Under Chromosome 1q21 Linkage Peak Are Associated With Type 2 Diabetes (2006) (25)
Epistasis Between Type 2 Diabetes Susceptibility Loci on Chromosomes 1q21‐25 and 10q23‐26 in Northern Europeans (2006) (25)
A girl with incomplete Prader–Willi syndrome and negative MS‐PCR, found to have mosaic maternal UPD‐15 at SNP array (2015) (24)
Breakthroughs in monogenic diabetes genetics: from pediatric forms to young adulthood diabetes. (2009) (24)
Isolation of the human LIM/homeodomain gene islet-1 and identification of a simple sequence repeat polymorphism [corrected]. (1994) (24)
Bio-Repository of DNA in stroke (BRAINS): A study protocol (2011) (24)
Isolation of the Human LIM/Homeodomain Gene Islet-1 and Identification of a Simple Sequence Repeat 1 (1994) (24)
Arginine-Induced Insulin Release in Glucokinase-Deficient Subjects (1994) (24)
VNTR polymorphism of the insulin gene and childhood overweight in a general population. (2004) (24)
EIF4A2 is a positional candidate gene at the 3q27 locus linked to type 2 diabetes in French families. (2006) (24)
Automated fluorescence-based screening for mutation by SSCP: use of universal M13 dye primers for labeling and detection. (1997) (23)
Lack of Association of CD36 SNPs With Early Onset Obesity: A Meta‐Analysis in 9,973 European Subjects (2011) (23)
The INS VNTR locus does not associate with smallness for gestational age (SGA) but interacts with SGA to increase insulin resistance in young adults. (2006) (23)
Association of Birth Weight With Type 2 Diabetes and Glycemic Traits (2019) (23)
Genetics of type 1 insulin-dependent diabetes mellitus. (1997) (23)
Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms (2016) (23)
Disentangling the Role of Melatonin and its Receptor MTNR1B in Type 2 Diabetes: Still a Long Way to Go? (2017) (23)
The expression of genes in top obesity-associated loci is enriched in insula and substantia nigra brain regions involved in addiction and reward (2019) (23)
Mutations of the human glucokinase gene and diabetes mellitus (1993) (23)
Analysis of the SIM1 Contribution to Polygenic Obesity in the French Population (2010) (23)
TCF7L2 rs7903146 variant does not associate with smallness for gestational age in the French population (2007) (23)
Association Analysis Indicates That a Variant GATA-Binding Site in the PIK3CB Promoter Is a Cis-Acting Expression Quantitative Trait Locus for This Gene and Attenuates Insulin Resistance in Obese Children (2008) (23)
Association between high von willebrand factor levels and the Thr789Ala vWF gene polymorphism but not with nephropathy in type I diabetes. The GENEDIAB Study Group and the DESIR Study Group. (2000) (22)
Absence of replication in the French population of the association between beta 2/NEUROD-A45T polymorphism and type 1 diabetes. (1999) (22)
Determination of peritoneal glucose kinetics in rats: implications for the peritoneal implantation of closed-loop insulin delivery systems (1989) (22)
Post-Bariatric Surgery Changes in Quinolinic and Xanthurenic Acid Concentrations Are Associated with Glucose Homeostasis (2016) (22)
A quantitative trait locus influencing type 2 diabetes susceptibility maps to a region on 5q in an extended French family. (2002) (22)
Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study (2022) (22)
A promoter polymorphism in CD36 is associated with an atherogenic lipid profile in a French general population. (2004) (22)
In Vitro and In Vivo Stability of Electrode Potentials in Needle-Type Glucose Sensors: Influence of Needle Material (1989) (22)
Genetic studies of the renin‐angiotensin system in arterial hypertension associated with non‐insulin‐dependent diabetes mellitus (1997) (21)
Genetic determinants of type 2 diabetes mellitus: lessons learned from family studies. (1993) (21)
An Automated Fluorescent Single-Strand Conformation Polymorphism Technique for Screening Mutations in the Hepatocyte Nuclear Factor-1α Gene (Maturity-Onset Diabetes of the Young) (1997) (21)
A Genome-Wide Scan for Childhood Obesity – Associated Traits in French Families Shows Significant Linkage on Chromosome 6 q 22 . 31-q 23 . 2 (2004) (21)
Identification of two novel loss‐of‐function SIM1 mutations in two overweight children with developmental delay (2014) (21)
Impaired histone deacetylases 5 and 6 expression mimics the effects of obesity and hypoxia on adipocyte function (2016) (21)
Early Detrimental Metabolic Outcomes of rs17300539‐A Allele of ADIPOQ Gene Despite Higher Adiponectinemia (2010) (21)
Parental history of type 2 diabetes, TCF7L2 variant and lower insulin secretion are associated with incident hypertension. Data from the DESIR and RISC cohorts (2013) (20)
Dissection of an inverted X(p21.3q27.1) chromosome associated with mental retardation (2003) (20)
A Genetic Study of the Ghrelin and Growth Hormone Secretagogue Receptor (GHSR) Genes and Stature (2009) (20)
Genetic Discrimination Between LADA and Childhood-Onset Type 1 Diabetes Within the MHC (2019) (20)
Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk (Nature Genetics (2010) 42 (105-116)) (2010) (20)
Cytokines d’origine adipocytaire, obésité et développement du diabète (2003) (20)
Macrophage gene expression in adipose tissue is associated with insulin sensitivity and serum lipid levels independent of obesity (2013) (19)
TCF7L2 is associated with type 2 diabetes in nonobese individuals from Tunisia. (2010) (19)
Changes in levels of peripheral hormones controlling appetite are inconsistent with hyperphagia in leptin-deficient subjects (2014) (19)
What Is the Best NGS Enrichment Method for the Molecular Diagnosis of Monogenic Diabetes and Obesity? (2015) (19)
Positional candidate gene analysis of Lim domain homeobox gene (Isl-1) on chromosome 5q11-q13 in a French morbidly obese population suggests indication for association with type 2 diabetes. (2002) (19)
The EIF2AK3 gene region and type I diabetes in subjects from South India (2004) (19)
CDKN2B expression and subcutaneous adipose tissue expandability: Possible influence of the 9p21 atherosclerosis locus (2014) (19)
Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration (2019) (19)
Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes (2019) (19)
Genetic and environmental nature of the insulin resistance syndrome in Indo-Mauritian subjects with premature coronary heart disease: contribution of β3-adrenoreceptor gene polymorphism and beta blockers on triglyceride and HDL concentrations (2001) (19)
High Prevalence of Rare Monogenic Forms of Obesity in Obese Guadeloupean Afro-Caribbean Children (2018) (18)
Role of the DGAT gene C79T single-nucleotide polymorphism in French obese subjects. (2003) (18)
SHP2 drives inflammation-triggered insulin resistance by reshaping tissue macrophage populations (2021) (18)
Gender effect of the Trp64Arg mutation in the beta 3 adrenergic receptor gene on weight gain in morbid obesity. (1997) (18)
The case for too little melatonin signalling in increased diabetes risk (2017) (18)
Impact of statistical models on the prediction of type 2 diabetes using non-targeted metabolomics profiling (2016) (18)
Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes (2022) (18)
Rare variants identified in the HNF-4α β-cell-specific promoter and alternative exon 1 lack biological significance in maturity onset diabetes of the young and young onset Type II diabetes (2002) (18)
No major contribution of TCF7L2 sequence variants to maturity onset of diabetes of the young (MODY) or neonatal diabetes mellitus in French white subjects (2006) (18)
Evaluating the association of common PBX1 variants with type 2 diabetes (2008) (18)
KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein Response. (2016) (18)
Chromosome 19p13.3 deletion in a patient with macrocephaly, obesity, mental retardation, and behavior problems (2011) (17)
Placental antiangiogenic prolactin fragments are increased in human and rat maternal diabetes. (2014) (17)
Characterization of the human SLC30A8 promoter and intronic enhancer. (2011) (17)
Minor contribution of SMAD7 and KLF10 variants to genetic susceptibility of type 2 diabetes. (2007) (17)
Evaluating the association of common APOA2 variants with type 2 diabetes (2008) (17)
Obesity susceptibility CART gene polymorphism contributes to bone remodeling in postmenopausal women (2005) (17)
Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death (2013) (17)
The Difficult Journey from Genome-wide Association Studies to Pathophysiology: The Melatonin Receptor 1B (MT2) Paradigm. (2016) (16)
A novel NEUROG3 mutation in neonatal diabetes associated with a neuro‐intestinal syndrome (2017) (16)
INS VNTR Is Not Associated With Childhood Obesity in 1,023 Families: A Family‐based Study (2008) (16)
Cofactors As Metabolic Sensors Driving Cell Adaptation in Physiology and Disease (2017) (16)
Generation of an induced pluripotent stem cell (iPSC) line from a patient with maturity-onset diabetes of the young type 3 (MODY3) carrying a hepatocyte nuclear factor 1-alpha (HNF1A) mutation. (2018) (15)
Evaluating the Association of FAAH Common Gene Variation with Childhood, Adult Severe Obesity and Type 2 Diabetes in the French Population (2008) (15)
Corrigendum: Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis (2011) (15)
Understanding the rising incidence of type 2 diabetes in adolescence (2004) (15)
Genetic analysis of Kruppel-like zinc finger 11 variants in 5864 Danish individuals: potential effect on insulin resistance and modified signal transducer and activator of transcription-3 binding by promoter variant -1659G>C. (2008) (14)
Genetic analyses of glucose transporter genes in French non-insulin-dependent diabetic families. (1997) (14)
The genetics of non-insulin-dependent diabetes mellitus: tools and aims (1994) (14)
Induction of TDO2 and IDO2 in Liver by High-Fat Feeding in Mice: Discrepancies with Human Obesity (2013) (14)
Diabetes in very young children and mutations in the insulin-secreting cell potassium channel genes: therapeutic consequences. (2007) (14)
Low-Frequency Variants in HMGA1 Are Not Associated With Type 2 Diabetes Risk (2012) (14)
Phenotyping is an accurate means of analysing the principal apolipoprotein E isoforms. (1994) (14)
Evaluating the association of common LMNA variants with type 2 diabetes and quantitative metabolic phenotypes in French Europids (2007) (14)
Familial early-onset diabetes is not a typical MODY in several Tunisian patients. (2012) (14)
Role of Ink4a/Arf Locus in Beta Cell Mass Expansion under Physiological and Pathological Conditions (2014) (14)
Meta‐analysis of genome‐wide DNA methylation and integrative omics of age in human skeletal muscle (2021) (14)
Mutation screening of the PPAR agene in type 2 diabetes associated with coronary heart disease (2008) (13)
Impact of a CART promoter genetic variation on plasma lipid profile in a general population. (2007) (13)
How Recent Advances in Genomics Improve Precision Diagnosis and Personalized Care of Maturity-Onset Diabetes of the Young (2019) (13)
Beta-cell secretory defect caused by mutations in glucokinase gene (1992) (13)
Genetic variation in the hepatocyte nuclear factor-3beta gene (HNF3B) does not contribute to maturity-onset diabetes of the young in French Caucasians. (2000) (13)
Allelic variation in exon 18 of the sulfonylurea receptor 1 (SUR1) gene, insulin secretion and insulin sensitivity in nondiabetic relatives of type 2 diabetic subjects. (2002) (13)
Loss‐of‐Function Mutations in MC4R Are Very Rare in the Greek Severely Obese Adult Population (2012) (13)
Analysis of KLF transcription factor family gene variants in type 2 diabetes (2007) (13)
Identification of Trinucleotide Repeat–Containing Genes in Human Pancreatic Islets (1996) (13)
Mutation screening of the urocortin gene: identification of new single nucleotide polymorphisms and association studies with obesity in French Caucasians. (2002) (12)
Familial mild hyperglycemia associated with a novel ABCC8‐V84I mutation within three generations (2011) (12)
Differential coexpression analysis of obesity-associated networks in human subcutaneous adipose tissue (2018) (12)
No association between the Friedreich's ataxia gene and NIDDM in the French population. (1998) (12)
Big Dye™ terminator cycle sequencing chemistry: Accuracy of the dilution process and application for screening mutations in the TCF1 and GCK genes (2000) (12)
The genetic structure of the world’s first farmers (2016) (12)
No contribution of angiotensin-converting enzyme (ACE) gene variants to severe obesity: a model for comprehensive case/control and quantitative cladistic analysis of ACE in human diseases (2007) (12)
corrigendum: Cloning of adiponectin receptors that mediate antidiabetic metabolic effects (2004) (12)
famCNV: copy number variant association for quantitative traits in families (2011) (12)
Fostering improved human islet research: a European perspective (2019) (12)
Triangulating evidence from longitudinal and Mendelian randomization studies of metabolomic biomarkers for type 2 diabetes (2021) (12)
The Q121 Variant of ENPP1 May Protect From Childhood Overweight/obesity in the Italian Population (2009) (11)
Genetic determinants of leucocyte telomere length in children: a neglected and challenging field. (2015) (11)
Prevalence of the missense mutation Gly574Ser in the hepatocyte nuclear factor-1alpha in Africans with diabetes. (2002) (11)
Response to Comment on: Marquez et al. Low-Frequency Variants in HMGA1 Are Not Associated With Type 2 Diabetes Risk. Diabetes 2012;61:524–530 (2012) (11)
Smallness for gestational age interacts with high mobility group A2 gene genetic variation to modulate height. (2009) (11)
Secretory granule neuroendocrine protein 1 (SGNE1) genetic variation and glucose intolerance in severe childhood and adult obesity (2007) (11)
Associations Between Type 2 Diabetes-Related Genetic Scores and Metabolic Traits, in Obese and Normal-Weight Youths. (2016) (11)
Examining the candidacy of ghrelin as a gene responsible for variation in adult stature in a United Kingdom population with type 2 diabetes. (2007) (11)
Effects of Genetic Susceptibility for Type 2 Diabetes on the Evolution of Glucose Homeostasis Traits Before and After Diabetes Diagnosis (2011) (10)
Maternal Glycemic Dysregulation During Pregnancy and Neonatal Blood DNA Methylation: Meta-analyses of Epigenome-Wide Association Studies (2022) (10)
Nuclear factors and type 2 diabetes. (1998) (10)
Genetic Causes of Severe Childhood Obesity: A Remarkably High Prevalence in an Inbred Population of Pakistan (2020) (10)
TCF 7 L 2 splice variants have distinct effects on b-cell turnover and function (2011) (10)
Characterization of human variants in obesity-related SIM1 protein identifies a hot-spot for dimerization with the partner protein ARNT2. (2014) (10)
Generation of an induced pluripotent stem cell (iPSC) line from a patient with maturity-onset diabetes of the young type 13 (MODY13) with a the potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) mutation. (2017) (10)
CoDE-seq, an augmented whole-exome sequencing, enables the accurate detection of CNVs and mutations in Mendelian obesity and intellectual disability (2018) (10)
Translational research: precision medicine, personalized medicine, targeted therapies: marketing or science? (2015) (10)
Epigenome-Wide Association Study Reveals Methylation Loci Associated With Offspring Gestational Diabetes Mellitus Exposure and Maternal Methylome (2021) (10)
Genetics of obesity: towards the understanding of a complex syndrome. (2000) (9)
Accurate single-nucleotide polymorphism allele assignment in trisomic or duplicated regions by using a single base-extension assay with MALDI-TOF mass spectrometry. (2011) (9)
Histone deacetylase 9 promoter hypomethylation associated with adipocyte dysfunction is a statin-related metabolic effect (2019) (9)
Emerging Roles for the INK4a/ARF (CDKN2A) Locus in Adipose Tissue: Implications for Obesity and Type 2 Diabetes (2020) (9)
Characterization of the LIM/Homeodomain Gene Islet-1 and Single Nucleotide Screening in NIDDM (1995) (9)
Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci (2020) (9)
The Map3k12 (Dlk)/JNK3 signaling pathway is required for pancreatic beta-cell proliferation during postnatal development (2020) (9)
LIFE SCRIPT How The Human Genome Discoveries Will Transform Medicine And Enhance Your Health (2002) (9)
Correction: Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults (2017) (9)
Non-sense mutation of glucokinase gene (1993) (9)
Nonradioactive screening of glucokinase mutations in maturity onset diabetes of the young. (1994) (9)
La mutation du gène du récepteur de la leptine entraîne chez l'homme une obésité massive associée à des anomalies hypothalamo-hypophysaires. (1998) (9)
CA repeat polymorphism in the glucose transporter GLUT 2 gene (1991) (9)
GAD2: a polygenic contribution to genetic susceptibility for common obesity? (2005) (8)
Evidence for tuning adipocytes ICER levels for obesity care (2012) (8)
Interaction between GPR120 p.R270H loss-of-function variant and dietary fat intake on incident type 2 diabetes risk in the D.E.S.I.R. study. (2016) (8)
From systems biology to systems medicine (2017) (8)
Circadian, Sleep and Caloric Intake Phenotyping in Type 2 Diabetes Patients With Rare Melatonin Receptor 2 Mutations and Controls: A Pilot Study (2020) (8)
Glucose-Dependent Regulation of NR2F2 Promoter and Influence of SNP-rs3743462 on Whole Body Insulin Sensitivity (2012) (8)
[Adipocytokins, obesity and development of type 2 diabetes]. (2003) (8)
A single-nucleotide polymorphism in the p110beta gene promoter is associated with partial protection from insulin resistance in severely obese adolescents. (2008) (8)
Tracking down genes to cure diabetes: an achievable task for the 21st century? (1997) (8)
Copy Number Variations in Candidate Genes and Intergenic Regions Affect Body Mass Index and Abdominal Obesity in Mexican Children (2017) (8)
R 125 W coding variant in TBC 1 D 1 confers risk for familial obesity and contributes to linkage on chromosome 4 p 14 in the French population (2008) (8)
Strategies for the collection of sibling-pair data for genetic studies in Type 2 (non-insulin-dependent) diabetes mellitus (1991) (7)
Molecular and cytogenetic characterisation of a small interstitial de novo 20p13→p12.3 deletion in a patient with severe growth deficit (2002) (7)
Glucokinase and MODY: from the Gene to the Disease (1996) (7)
Decreased STARD 10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice (2017) (7)
Monogenic Forms of Diabetes in the Young (2008) (7)
Diabète néonatal : une maladie aux multiples mécanismes (2007) (7)
A rare mutation in ABCC8/SUR1 leading to altered KATP channel activity and β-cell glucose sensing is associated with type 2 diabetes mellitus in adults (2007) (7)
[Genetics of type II diabetes]. (1995) (7)
Human diabetes and obesity: tracking down the genes. (1995) (7)
Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretion (2019) (7)
NACHO: an R package for quality control of NanoString nCounter data (2019) (7)
Maturity-onset diabetes of the young. (1994) (7)
[ENPP1, the first example of common genetic link between childhood and adult obesity and type 2 diabetes]. (2006) (7)
Monogenic diabetes characteristics in a transnational multicenter study from Mediterranean countries. (2020) (7)
Contribution of rare coding mutations in CD36 to type 2 diabetes and cardio-metabolic complications (2019) (6)
The unique clinical spectrum of maturity onset diabetes of the young type 3. (2018) (6)
Genome-wide Association Study of Change in Fasting Glucose over time in 13,807 non-diabetic European Ancestry Individuals (2019) (6)
Random glucose GWAS in 493,036 individuals provides insights into diabetes pathophysiology, complications and treatment stratification (2021) (6)
Studies of a genetic variant in HK1 in relation to quantitative metabolic traits and to the prevalence of type 2 diabetes (2011) (6)
Investigation of the HIN200 Locus in UK SLE Families Identifies Novel Copy Number Variants (2011) (6)
A Novel Rare Missense Variation of the NOD2 Gene: Evidences of Implication in Crohn’s Disease (2018) (6)
Islet-brain 1/c-Jun N-terminal kinase interacting protein-1 (IB1/JIP-1) promoter variant is associated with Alzheimer's disease (2003) (6)
Monogenic forms of diabetes mellitus: an update. (2009) (6)
ALDH2 Polymorphism rs671, but Not ADH1B Polymorphism rs1229984, Increases Risk for Hypo-HDL-Cholesterolemia in a/a Carriers Compared to the G/G Carriers. (2018) (6)
No evidence for diabetes-associated mutations of PEK/EIF2AK3 gene in French patients with early-onset Type II diabetes (2001) (6)
Common variants near BDNF and SH2B1 show nominal evidence of association with snacking behavior in European populations (2013) (6)
Type 2 Diabetes: Genetic Factors (2002) (6)
The Genetics of Type 2 Diabetes: From Candidate Gene Biology to Genome‐Wide Studies (2010) (6)
Clustering for a better prediction of type 2 diabetes mellitus (2021) (6)
Transcription profiling in the liver of undernourished male rat offspring reveals altered lipid metabolism pathways and predisposition to hepatic steatosis. (2019) (6)
Avancées dans la génétique de la glycémie à jeun - Quelles leçons pour le diabète ? (2009) (6)
[Adipocytokins, obesity and development of type 2 diabetes]. (2005) (5)
Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways (2022) (5)
Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood (2020) (5)
Transmission of Type 2 diabetes to sons and daughters: the D.E.S.I.R. cohort (2017) (5)
No evidence for linkage or for diabetes-associated mutations in the activin type 2B receptor gene (ACVR2B) in French patients with mature-onset diabetes of the young or type 2 diabetes. (2001) (5)
Characterization of a Bvg-regulated fatty acid methyl-transferase in Bordetella pertussis (2017) (5)
The Interplay of Variants Near LEKR and CCNL1 and Social Stress in Relation to Birth Size (2012) (5)
Génétique de l'obésité: vers la compréhension d'un syndrome complexe. (2000) (5)
Distinct virulence ranges for infection of mice by Bordetella pertussis revealed by engineering of the sensor-kinase BvgS (2018) (5)
Gain of function of Malate Dehydrogenase 2 (MDH2) and familial hyperglycemia. (2021) (4)
Meta-analysis of genome-wide DNA methylation and integrative OMICs in human skeletal muscle (2020) (4)
Mutations in G6PC2 do not contribute to monogenic forms of early infancy diabetes and beta cell dysfunction (2009) (4)
8th Santorini Conference: Systems medicine and personalized health and therapy, Santorini, Greece, 3–5 October 2016 (2017) (4)
Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls (2018) (4)
Génétique du diabète non insulinodépendant (1994) (4)
Erratum: The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation (2016) (4)
Recherche translationnelle : médecine personnalisée, médecine de précision, thérapies ciblées : marketing ou science ? (2015) (4)
Glucose Regulates m6A Methylation of RNA in Pancreatic Islets (2022) (4)
Weight loss independent association of TCF7 L2 gene polymorphism with fasting blood glucose after Roux-en-Y gastric bypass in type 2 diabetic patients. (2014) (4)
Recherche translationnelle : médecine personnalisée, médecine de précision, thérapies ciblées : marketing ou science ? (2015) (4)
A de novo synonymous variant in EFTUD2 disrupts normal splicing and causes mandibulofacial dysostosis with microcephaly: case report (2020) (4)
CDKN 2 B expression and subcutaneous adipose tissue expandability : Possible influence of the 9 p 21 atherosclerosis locus (2014) (4)
Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretion (2021) (4)
[Neonatal diabetes: a disease linked to multiple mechanisms]. (2007) (4)
Concordance of two multiple analytical approaches demonstrate that interaction between BMI and ADIPOQ haplotypes is a determinant of LDL cholesterol in a general French population (2010) (4)
Rare Variant Analysis of Obesity-Associated Genes in Young Adults With Severe Obesity From a Consanguineous Population of Pakistan. (2022) (4)
Maturity Onset Diabetes of the Young (Mody) (2001) (3)
TCF 7 L 2 rs 7903146 – macronutrient interaction in obese individuals ’ responses to a 10-wk randomized hypoenergetic diet 1 – 3 (2010) (3)
An Automated Fluorescent Single-Strand Conformation Polymorphism Technique for Screening Mutations in the Hepatocyte Nuclear Factor-la Gene (Maturity-Onset Diabetes of the Young) Boutin, Jean Claude Chevre, El Habib Hani, Ramon Gomis, Victor C. Pardini, (1997) (3)
The Case | Hypokalemia and severe renal loss of sodium. (2020) (3)
[Genomic approach to obesity: understanding a complex syndrome]. (2000) (3)
[Inputs from the genetics of fasting glucose: lessons for diabetes]. (2009) (3)
Next-generation sequencing for identifying new genes in rare genetic diseases: many challenges and a pinch of luck (2013) (3)
Supplementary Material 5 (2014) (3)
Signatures of TSPAN8 variants associated with human metabolic regulation and diseases (2020) (3)
[Maturity-onset diabetes of the young (MODY): the history of its dismemberment]. (2003) (3)
Erratum: Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia (2009) (3)
Supplementary Material 7 (2014) (3)
First Genome-Wide Search for Young-Onset Obesity Susceptibility Genes Shows 3 Loci on 6q, 15q and 16q (2002) (3)
Role of Homeodomain Transcription Factor IPF-1 in the Pathogenesis of Diabetes mellitus (2000) (3)
Les marqueurs génétiques du diabète de type 2 (1996) (3)
Supplementary Material 6 (2014) (3)
A genetic variant in HK 1 is associated with pro-anemic state and HbA 1 c but not other glycemic control related traits Running head : HK 1 variant , glycated hemoglobin and anemia (2009) (3)
Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: an overview of the data from the epidemiological studies within the IMI DIRECT Consortium (2018) (3)
DIABETE ET HEREDITE (1991) (3)
Monogenic forms of diabetes mellitus: an update. (2009) (3)
Supplementary Material 3 (2015) (3)
L'État du monde 2010 : 50 idées-forces pour comprendre : Le grand tournant ? (2009) (3)
D-glucose metabolism in lymphocytes of patients with mitochondrial point mutation of the tRNALeu(UUR) gene. (1995) (3)
Medical Genetics of MODYs (2000) (2)
Correction: Genetic Polymorphisms and Weight Loss in Obesity: A Randomised Trial of Hypo-Energetic High- versus Low-Fat Diets (2006) (2)
PLCL1 rs7595412 variation is not associated with hip bone size variation in postmenopausal Danish women (2009) (2)
[Obesity genes and their effect on the energy balance]. (2015) (2)
University of Groningen Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk (2011) (2)
Two TaqI RFLPs at the GLUT2 locus in French Caucasian population. (1991) (2)
Obesity: Genetics, Behavior or a Combination of Both (2004) (2)
The relationship between paraoxonase polymorphism and plasma lipids/lipoproteins in non-insulin dependent diabetes (1995) (2)
Dominant negative mutation in oxalate transporter SLC26A6 associated with enteric hyperoxaluria and nephrolithiasis (2022) (2)
Differential hypothalamic gene expression profile after, intracerebroventricular infusion of lipids for 48h in Wistar rats. (2003) (2)
Identification of genetic factors associated with Type 2 Diabetes in Saudis: The lessons from European studies (2010) (2)
22nd European Congress on Obesity (ECO2015), Prague, Czech Republic, May 6-9, 2015: Abstracts (2015) (2)
Insulin gene mutations resulting in a MODY phenotype: marked differences in clinical presentation, metabolic status and pathogenic effect through ER retention (2009) (2)
Amutation in thehuman leptin receptorgenecausesobesity andpituitarydysfunction (1998) (2)
Les gènes de l’obésité et leur contribution à la balance énergétique (2015) (2)
Investigation of the role of the T to G SNP in the adiponectin (AMP1) gene in abdominal obesity using parent-offspring trios (2002) (2)
A high density genome-wide association study identifies novel susceptibility genes for type 2 diabetes mellitus and reveals new mechanisms for glucose intolerance (2007) (2)
Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids (2019) (2)
Short Technical Repor t Rapid SNP Allele Frequency Determination in Genomic DNA Pools by Pyrosequencin g (2002) (2)
La génomique à l'épreuve du marché boursier : faut-il avoir peur des sociétés de biotechnologie génétique ? (1997) (2)
Non-isotopic and sensitive method for diagnosis of maternally-inherited diabetes and deafness (1994) (2)
Machine Learning in Multi-Omics Data to Assess Longitudinal Predictors of Glycaemic Trait Levels (2018) (2)
Novel biomarkers for glycaemic deterioration in type 2 diabetes: an IMI RHAPSODY study (2021) (2)
Clinical andMetabolic Features of Adult-Onset Diabetes Caused by ABCC 8 Mutations (2011) (2)
Récepteurs de la mélanocortine et obésité humaine. (2001) (2)
Structural Elements Directing G Proteins and β-Arrestin Interactions with the Human Melatonin Type 2 Receptor Revealed by Natural Variants (2022) (2)
Jointly Modelling Single Nucleotide Polymorphisms With Longitudinal and Time-to-Event Trait: An Application to Type 2 Diabetes and Fasting Plasma Glucose (2018) (2)
Obesity status modifies the association between rs7556897T>C in the intergenic region SLC19A3-CCL20 and blood pressure in French children (2020) (2)
ENPP1, premier exemple d’un déterminant génétique commun à l’obésité et au diabète de type 2 (2006) (2)
Mo1139 Coffee Consumption Genetic Polymorphisms in CYP1A2 and NAT2, and Colorectal Cancer Risk (2013) (2)
FAD-glycerophosphate dehydrogenase activity in lymphocytes of patients with mitochondrial mutation of the tRNA(Leu(UUR)) gene (1995) (2)
Issue Information (2018) (2)
Supplementary Material 4 (2015) (1)
Du nouveau dans la génétique des formes monogéniques d’obésité et son impact pour mieux en comprendre la physiopathologie (2020) (1)
Novel Genetic Loci Implicated in Fasting Glucose Homeostasis and Their Impact on Related Metabolic Traits (2009) (1)
L'histoire du démembrement des diabètes MODY (2003) (1)
The role of transcription factors in the pathogenesis of type 2 diabetes. (1999) (1)
Genetics of Obesity (2011) (1)
Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability (2021) (1)
The transcription factor E2F1 controls the GLP-1 receptor pathway in pancreatic β cells. (2022) (1)
Supplementary Material 15 (2013) (1)
A genome scan reveals heterogeneity among European families with maturity onset diabetes of the young (2001) (1)
CO-37: Les dommages à l'ADN et l'activation de la voie p53 dans l'adipocyte contribuent au développement de l'inflammation du tissu adipeux durant l'obésité (2016) (1)
1 Disruption of a Novel KLF-p 300-Regulated Pathway for Insulin Biosynthesis Revealed by Studies of the c .331 INS Mutation Found in Neonatal Diabetes Mellitus (2011) (1)
Pathogen-induced systemic plant signal triggers DNA rearrangements (2003) (1)
Approches génomiques de l'obésité : vers la compréhension d'un syndrome complexe (2000) (1)
mulTI-cohorT GeneTIc assocIaTIon sTudy reVeals cXcr 6 as a new chemokIne recePTor InVolVed In aIds lonG-Term non-ProGressIon (2011) (1)
European Obesity Summit (EOS) – Joint Congress of EASO and IFSO-EC, Gothenburg, Sweden, June 1 – 4, 2016: Abstracts (2016) (1)
Two Caucasian families with the hepatocyte nuclear factor-1alpha mutation Tyr218Cys. (2007) (1)
In vitro and in vivo stability of needle-type glucose sensors: influence of needle material (1989) (1)
[Recent advances in the genetics of obesity]. (2000) (1)
Mechanisms behind the immediate effects of Roux-en-Y gastric bypass surgery on type 2 diabetes (2013) (1)
Le régulateur du cycle cellulaire E2F1 module l’expression du récepteur au GLP-1 dans la cellule beta pancréatique (2017) (1)
Subject Index Vol. 94, 2001 (2001) (1)
Maturity-Onset Diabetes of the Young: From Genetics to Translational Biology and Personalized Medicine (2017) (1)
[Glucokinase and non-insulin-dependent diabetes: from gene to disease]. (1993) (1)
Book Review Obesity: Mechanisms and Clinical Management Edited by Robert H. Eckel. 592 pp., illustrated. Philadelphia, Lippincott Williams & Wilkins, 2003. $129. 0-7817-2844-4 (2004) (1)
Effect of Sex and Underlying Disease on the Genetic Association of QT Interval and Sudden Cardiac Death (2019) (1)
Excessive fetal growth affects HSC quiescence maintenance through epigenetic programming of EGR1 transcriptional network (2021) (1)
The effect of sex and underlying disease on the genetic association of QT interval and sudden cardiac death (2019) (1)
Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity (2019) (1)
Is ghrelin involved in BMI determination in patients with type 2 diabetes (2005) (1)
Pancreatic β-cell specific loss of E2f1 impairs insulin secretion and β-cell identity through the epigenetic repression of non β-cell programs (2020) (1)
Trans-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes (2021) (1)
Comment on Beltrand et al. Sulfonylurea Therapy Benefits Neurological and Psychomotor Functions in Patients With Neonatal Diabetes Owing to Potassium Channel Mutations. Diabetes Care 2015;38:2033–2041 (2016) (1)
Difficulties in the diagnosis aetiology of A- β- ketosis-prone diabetes in a North- African adult (2016) (1)
O88 Variabilité de l’effet de la chirurgie bariatrique en fonction du génotype de MC4R (2010) (1)
Identification of Key Regions Mediating Human Melatonin Type 1 Receptor Functional Selectivity Revealed by Natural Variants (2021) (1)
The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels, and reduces type 2 diabetes risk in a prospective general French population: the D.E.S.I.R. Study (2008) (1)
Copy Number Variants and Their Contribution to the Risk of Obesity (2014) (1)
Supplementary Material 9 (2013) (1)
Role of red blood cells (RBC) in amino acid (AA) interorgan transport in vivo in man: a stable isotope study (1987) (1)
P132 - Des variants peu fréquents dans le gène HMGA1 pourraient être associés au diabète de type 2 (2011) (1)
A Genome Wide Association Search for Type 2 Diabetes Genes in Arabic Populations (2016) (1)
High-density association mapping and comprehensive tagging of the type 2 diabetes linkage region on chromosome 1q in 4 European populations (2007) (1)
Paraoxonase polymorphism in non-insulin dependent diabetes: A link between lipid oxidation and coronary heart disease (1995) (1)
Genetic analyses of the QT interval and its components in over 250K individuals identifies new loci and pathways affecting ventricular depolarization and repolarization (2021) (1)
Multi-ancestry genome-wide smoking interaction study of 387,272 individuals identifies novel lipid loci. (2019) (1)
Contribution of heterozygous PCSK1 variants to obesity and implications for precision medicine: a case-control study. (2023) (1)
Genetic and obesity (1997) (1)
Putative association signals identified through high-density LD mapping of the replicated T2D linkage region on chromosome 1q are not confirmed in large-scale follow-up studies (2008) (1)
Pharmacogenomics in admixed populations: the Brazilian pharmacogenetics/pharmacogenomics network—REFARGEN (2004) (1)
Contribution of Type 2 diabetes associated loci in the Arabic Population from Tunisia and trans-ethnic genetic heterogeneity (2008) (1)
Génétique dans le diabète de type 2 (2000) (1)
[Genetics of non-insulin-dependent diabetes mellitus: the end of the nightmare?]. (1992) (1)
L'enquête familiale est-elle utile dans le diabète de type 2 (1990) (1)
Génétique du diabète de type 2 (1997) (1)
Historical Overview of Gene Discovery Methodologies in Type 2 Diabetes (2016) (1)
Corrigendum to “High prevalence of leptin and melanocotin-4 receptor gene mutations in children with severe obesity from Pakistani consanguineous families” [Mol. Genet. Metab. 106/1 (2012) 121–126] (2013) (1)
A reference map of potential determinants for the human serum metabolome (2020) (1)
Track 1 – Track 5 (2008) (0)
Variants génétiques associés à la trajectoire de la glycémie à jeun et à l’incidence du diabète de type 2 : Une approche par modèle joint (2017) (0)
O66 Critères cliniques permettant l’identification de patients « MODY X » pour un criblage génétique élargi (2013) (0)
Mutations exomiques rares transmises au sein de familles de type MODY : analyse de corrélation avec la variabilité phénotypique et les défauts métaboliques précoces (2017) (0)
E2F1 maintient l’identité et la fonction des cellules β pancréatiques matures (2018) (0)
PO27 Diagnostic moléculaire simultané de 43 formes monogéniques de diabète et d’obésité : un pas vers la médecine métabolique Personnalisée (2013) (0)
Augmentation de l’expression de la prolactine placentaire dans un modèle de rate gestante diabétique (2012) (0)
E2F1 module la sécrétion d’insuline contrôlée par le GLP-1 dans la cellule beta pancréatique mature (2018) (0)
O68 La rapamycine augmente la réponse inflammatoire et l’émergence des cellules « Myeloïd-derived Suppressor Cells » (MDSC) chez la souris obèse (2013) (0)
P202 Utilisation des cellules souches somatiques pour modéliser le diabète monogénique lié aux anomalies du canal potassique de KCNJ11 (2015) (0)
O52 L’activité enzymatique plasmatique de l’amylase pancréatique est associée à une diminution de l’indice de masse corporelle et protège du risque de diabète dans la cohorte D.E.S.I.R. (2015) (0)
O50 La protéine P300/CBP-associated factor (PCAF) est une histone acetyl-transferase qui contrôle la fonction de la cellule ß pancréatique (2013) (0)
O17 La rapamycine régule le métabolisme en augmentant l’inflammation du tissu adipeux blanc (2012) (0)
CO82 - Le génotype TT du polymorphisme C-58T du récepteur de type 2 à la bradykinine (BDKRB2) est associé à un risque augmenté de diabète de type 2 (DT2) dans la population générale : l’étude DESIR (2008) (0)
Le diabète du bébé (2008) (0)
PO25 Les Grandes Duplications Chromosomiques Contribuent au Risque d’Obésité (2013) (0)
L’ère du gros (2009) (0)
Approche génétique du diabète non insulino-dépendant: résultats récents et perspectives (1993) (0)
P126 - Absence de mutations des gènes HNF1A, HNF4A et INS chez dix patients tunisiens avec un diabète de type MODY (2011) (0)
O25 Les nouveaux gènes associés au diabète de type 2 : impact dans des populations non européennes et mesure de leurs effets combinés (2008) (0)
P128 Identification de nouveaux polymorphismes génétiques associés au risque de diabète de type 2 chez les obèses et non obèses européens (2012) (0)
O99 La mutation fréquente non synonyme P446L de GCK-RP module inversement la glycémie et les triglycérides, et réduit le risque de diabète de type 2 dans la population générale française D.E.S.I.R (2008) (0)
P204 Le variant Q121 et l’haplotype (QdelTG) d’ENPP1 prédispose à l’obésité infantile : une méta-analyse de six études cas témoins (2010) (0)
Génétique des complications du diabète sucré : quels sont actuellement les gènes incriminés ? : Diabète (1994) (0)
O2 L’extinction de la biosynthèse d’insuline via l’altération d’un site de fixation du facteur de transcription KLF11 entraîne une forme congénitale de diabète néonatal (2011) (0)
La paraoxonase, un nouveau facteur de risque cardiovasculaire dans le diabète non-insulino-dépendant. (1996) (0)
P196 Deux transcrits alternatifs de TCF7L2 interagissent spécifiquement avec la protéine HNF4alpha dans les cellules HepG2 (2014) (0)
Avancées et promesses de la médecine de précision personnalisée des maladies métaboliques1 (2022) (0)
Génétique du diabète non insulinodépendant: des gènes à la maladie : De la fonction aux maladies glomérulaires (1994) (0)
P222 Expression différentielle de transcrits alternatifs de TCF7L2 dans le foie humain diabétique, et leur induction par l’insuline dans les cellules hépatiques HepG2. (2012) (0)
Le régulateur du cycle cellulaire E2F1 maintient l’identité et la fonction des cellules β pancréatiques (2017) (0)
P46 Variation de l’expression placentaire du gène decidual-prolactin-related-protein (DPRP) et des fragments antiangiogéniques de la prolactine au cours du diabète maternel (2014) (0)
O31 Deux scores de risque génétique sont fortement associés aux variations de glycémie à jeun et à l’incidence d’hyperglycémie et de diabète de type 2 dans l’étude prospective D.E.S.I.R (2014) (0)
P273 Les récepteurs « toll-like » sont surexprimés dans le tissu adipeux omental humain et sont potentiellement impliqués dans l’initiation de l’inflammation de ce compartiment (2010) (0)
O17 Un faible nombre de copies du gène de l’alpha-amylase est associé à un profil métabonomique d’insulino-résistance via le microbiome intestinal (2014) (0)
O8 Une déficience partielle en prohormone convertase 1 confère une augmentation du risque de l’obésité (2010) (0)
CO-16: Nouveaux marqueurs épigénétiques spécifiques du foie chez les obèses diabétiques de type 2 (2016) (0)
O47 Dérégulation de la voie des kynurénines dans le diabète de type 2 associé à l’obésité (2014) (0)
Vers un dépistage génétique et un traitement préventif du diabète non insulino-dépendant (1993) (0)
O39 L’invalidation de Cdkn2a chez la souris protège de l’obésité et du diabète de type 2 en induisant la conversion du tissu adipeux blanc en brun (2015) (0)
Deux cousins germains avec un même phénotype d’obésité et d’insuffisance corticotrope, un seul est déficient POMC, cherchez l’erreur (2023) (0)
Génétique du diabète de type 2 et de l’obésité : où en sommes-nous ? Que pouvons-nous en attendre ? (2011) (0)
Génétique et prévention des pathologies de l'obésité (2002) (0)
P172 Conséquences métaboliques d’une nouvelle mutation du gène ABCC8/SUR1 présente chez un patient diabétique de type 2 adulte et sa descendance (2008) (0)
P347 - TCF7L2 ne joue pas un rôle majeur dans le diabète de type 2 dans la population obèse morbide française (2008) (0)
Quand l'Angleterre veut imiter la France (2008) (0)
P275 Les récepteurs à la leptine ont une organisation plus complexe que de simples homomères (2010) (0)
Bases génétiques du diabète non insulino-dépendant (1996) (0)
Glucokinase et diabète non insulino-dépendant: du gène à la maladie. (1993) (0)
O67 L’analyse du transcriptome montre une dysfonction foeto-placentaire au cours du diabète maternel (2012) (0)
O10 Une méta-analyse GWA de la glycémie après 2 h d’HGPO révèle que GIPR est associé avec la sécrétion de l’insuline en réponse au glucose et que ADCY5 est un nouveau gène de susceptibilité au diabète de type 2 (2010) (0)
Excès de variants rares délétères au sein de gènes appartenant à la voir JAK-STAT chez des patients atteints de pneumopathie interstitielle diffuse associée à la polyarthrite rhumatoïde (2022) (0)
La lipomatose de Launois-Bensaude due aux mutations de MFN2 : spectre clinique et impact sur le tissu adipeux (2018) (0)
Le sÃ©quenÃ§age de nouvelle gÃ©nÃ©ration pour le diagnostic gÃ©nÃ©tique du diabÃ¨te non auto-immun monogÃ©nique permet de diagnostiquer 66% des patients dâune cohorte soigneusement sÃ©lectionnÃ©e. (2018) (0)
Comment le programme d’investissements d’avenir a-t-il stimulé la recherche et l’innovation en santé? (2022) (0)
O35 Facteurs génétiques et risque de dysglycémie dans des familles de diabétiques de type 2: l’étude DESCENDANCE (2015) (0)
O86 Déclin accéléré de la fonction bêta en fonction du génotype TCF7L2 après le diagnostic de diabète dans la cohorte D.E.S.I.R. (2011) (0)
O60 Plusieurs variants géniques de risque pour l’obésité ont un impact sur le grignotage et le comportement boulimique (2012) (0)
Obésité, diabète de type 2 et prédisposition génðique (2002) (0)
P350 - Les variants génétiques de KLF11 sont impliqués dans la résistance de l’insuline via la régulation des gènes de la gluconéogenèse (2008) (0)
Une indication de liaison génétique de la région du gène de la leptine (gène OB) avec l'obésité massive humaine (1996) (0)
O61 Le diabète de type 2 est responsable d’anomalies chromosomiques somatiques en mosaïques qui sont pré-cancéreuses (2013) (0)
O5 Des mutations du gène de la préproinsuline altèrent la maturation de l’insuline et entraînent un diabète non auto-immun chez l’enfant et de type Mody (2009) (0)
Génétique et obésité (1997) (0)
O53 L’altération du récepteur des acides gras insaturés de type omega-3 GPR120 entraîne une obésité chez l’Homme et la Souris (2012) (0)
Qu'avons-nous appris grâce à la génétique dans le diabète de type 2 et ses complications? (1999) (0)
PO13 Identification par séquençage de nouvelle génération de deux nouvelles mutations situées dans LEPR, chez des enfants pakistanais avec une obésité sévère et issus de familles consanguines (2014) (0)
CO81 - Risque prédictif de variants génétiques associés au Diabète de Type 2 dans la cohorte prospective française DESIR (2008) (0)
P2084 Méthylation de l’ADN dans le foie et diabète de type 2 : une étude pilote (2013) (0)
UNE MUTATION DU GENE DU RECEPTEUR DU GLUCAGON DANS LE DIABETE NON INSULINODEPENDANT (1995) (0)
Premiers enseignements de l’étude DESCENDANCE : prévalence des dysglycémies méconnues chez des apparentés de diabétiques de type 2 sur deux générations (2014) (0)
P193 Le répresseur transcriptionel ICER est essentiel au contrôle de l’homéostasie glucidique et du rythme circadien dans les îlots pancréatiques (2014) (0)
Un nouveau gène du diabète insulino-dépendant sur le chromosome 11q. Le DID, paradigme pour l'étude des maladies multifactorielles (1994) (0)
O98 Des variants du promoteur du gène G6PC2 pourraient expliquer la contribution de ce locus au contrôle génétique de la glycémie (2009) (0)
O100 L’architecture génétique du diabète de type 2 est modulée par le statut d’obésité (2008) (0)
Quel est le poids des gènes dans l’obésité ? (2018) (0)
P199 L’inactivation génique de Cdkn2a chez la souris protège de l’obésité et du diabète de type 2 en modulant le métabolisme oxydatif (2014) (0)
C-Jun amino terminal kinase 3 (JNK3) contrôle la masse fonctionnelle de la cellule bêta en réponse à l’obésité (2017) (0)
Prevention et traitement du diabete sucre. Utilisation de techniques de biologie moleculaire et de genie biomedical en diabetologie clinique et experimentale (1991) (0)
P1051 Analyse des transcrits alternatifs de TCF7L2 et de leur implication dans la régulation de la néoglucogénèse dans le foie (2013) (0)
P92 Corpulence dans l’enfance et l’adolescence et risque de dysglycémie connue ou non dans des familles de diabétiques de type 2. L’étude DESCENDANCE (2014) (0)
O5 La lysine acetyl-transferase P300/CBP-associated factor (PCAF) contrôle la sécrétion d’insuline et la réponse au stress du reticulum (2014) (0)
Cytokines d'origine adipocytaire, et développement (2003) (0)
Les échanges d'acides aminés entre plasma et globules rouges : étude in vivo chez l'homme par les isotopes stables (1988) (0)
P346 - Nouvelles mutations activatrices du gène ABCC8/SUR1 dans le diabète néonatal transitoire et chez l’adulte (2008) (0)
Le séquençage de nouvelle génération pour le diagnostic génétique du diabète non auto-immun monogénique permet de diagnostiquer 66% des patients d’une cohorte soigneusement sélectionnée. (2018) (0)
Fond génétique partagé entre la pneumopathie interstitielle diffuse associée à la polyarthrite rhumatoïde et la fibrose pulmonaire idiopathique (2016) (0)
O33 Le profilage métabolomique précoce améliore la prédiction du diabète de type 2 (2015) (0)
O33 Le profilage métabolomique précoce améliore la prédiction du diabète de type 2 (2015) (0)
O36 Methylation de l’ADN dans le foie et diabète de type 2 (2014) (0)
O06 Le mutant perte de fonction p.R46L de PCSK9 n’est pas associé à un risque accru de diabète chez l’homme (2015) (0)
O57 Des variations du nombre de copies au niveau d’un CNV fréquent contribuent très fortement au risque d’obésité (2012) (0)
CO-50: E2F1 maintient l'identité et la fonction des cellules β pancréatiques (2016) (0)
Physiopathologie du diabète (2018) (0)
Diabète néonatal (monogénique de la très petite enfance). État des travaux du Réseau Français d’étude du diabète néonatal. (2012) (0)
Pharmacie et génomique : Réponse à Robert Vachy. (1998) (0)
CA-195: Association indépendante de la perte de poids, entre l'amélioration de l'homéostasie glycémique après chirurgie bariatrique et les concentrations de certaines kynurénines circulantes (2016) (0)
P210 Nouvelles Approches dans l’Étude des Diabètes Monogéniques chez l’Enfant et l’Adulte Jeune, et Distribution des Étiologies Génétiques à partir de la Cohorte du Réseau d’Étude Français (2010) (0)
O21 Des mutations du facteur de transcription hypothalamique SIM1 sont responsables d’obésité sévère monogénique de l’enfant (2009) (0)
Impact des mutations rares des gÃ¨nes du diabÃ¨te monogÃ©nique sur le risque de diabÃ¨te de type 2 commun, via le sÃ©quenÃ§age de 5 300 sujets franÃ§ais (2018) (0)
O59 Identification de nouvelles mutations associées au diabète néonatal grâce à l’utilisation de techniques (pan) génomiques incluant le séquençage de nouvelle génération (2015) (0)
Identification de 4 nouveaux gènes à risque de diabète de type 2 modulant la fonction β pancréatique et l’insulino-sécrétion (2017) (0)
Génétique du diabète non insulino-dépendant: la fin du cauchemar? (1992) (0)
Génétique du diabète de type 2 : vers une médecine prédictive et préventive ? (1993) (0)
PO11 Deux nouveaux loci associés au diabète de type 2 dans la population mexicaine identifiés par les puces Metabochip (2015) (0)
O9 L’Extinction de l’Activité du Promoteur du Gène de l’Insuline Entraîne une Forme Congénitale de Diabète Néonatal Transitoire (2010) (0)
P1027 L’activation de la voie de dégradation du tryptophane interfère avec le métabolisme des adipocytes (2013) (0)
CO83 - Identification de nouveaux gènes de susceptibilité au diabète de type 2 par une étude d’association génome entier par puces à ADN dans la population française (2008) (0)
O97 Des variants du gène MTNR1B du récepteur 2 à la mélatonine augmentent la glycémie et le risque de DT2 : un lien entre le rythme circadien et le diabète ? (2009) (0)
P349 - Étude de la contribution du gène de la prohormone convertase 1 (PCSK1) à l’obésité polygénique (2008) (0)
P348 - Le polymorphisme K121Q d’ENPP1 est associé à l’obésité sévère et au diabète de type 2 familial, et augmente l’incidence de l’hyperglycémie dans l’étude prospective DÉSIR (2008) (0)
P208 Quels Sont Les Facteurs Génétiques Associés Au Diabète De Type 2 Chez Les Marocains (2010) (0)
CO9 - Les variants du gène CNR1 codant le récepteur aux cannabinoïde 1 augmentent le risque d’obésité et de diabète de type 2 et prédisposent à la mortalité cardiovasculaire (2008) (0)
Génétique et diabètes (1994) (0)
O58 Une nouvelle cause curable de MODY et de DT2 de l’adulte jeune révélée par une mutation de KCNJ11, codant la sous-unité Kir6.2 du canal potassique ATP-dépendant (2012) (0)
PO39 Le tissu adipeux blanc régule le métabolisme du tryptophane dans l’obésité humaine : conséquences sur l’inflammation et la pression artérielle (2012) (0)
O4 Splicing alternatif de TCF7L2 et fonction bêta-pancréatique (2011) (0)
CO-68: L'étude génomique et fonctionnelle des gènes du diabète de type 2 confirme leur rôle dans les cellules beta-pancréatiques (2016) (0)
O89 La consommation de lipides et les polymorphismes du locus PPARG modulent l’indice de masse corporelle et le risque de diabète de type 2 dans l’étude prospective D.E.S.I.R. (2011) (0)
Cartographie de gènes de prédisposition au diabète non insulinodépendant dans un modèle de diabète spontané chez le rat (1996) (0)
Réduction de l’expression de STARD10 associée à une altération de la sécrétion d’insuline chez l’homme et la souris (2017) (0)
PO9 Rôle de la signalisation de JNK dans l’adaptation des cellules béta-pancréatiques au cours de la grossesse et de l’obésité (2013) (0)
Contents Vol. 123, 2008 (2009) (0)
Contents Vol. 94, 2001 (2002) (0)
The genetics of complex traits: from diabetes mellitus to obesity. (1998) (0)
The ghrelin gene : Candidacy in stature 1 Examining the candidacy of ghrelin as a gene responsible for variation in adult stature in a UK population with type 2 diabetes (2007) (0)
Issue Information (2018) (0)
Epigenetic changes associated with hyperglycaemia exposure in the longitudinal D.E.S.I.R. cohort. (2022) (0)
Large-scale association studies to identify diabetes-susceptibility loci on chromosome 1q: The importance of stringent quality control (2006) (0)
[Diabetes and heredity]. (1991) (0)
Abstract 14459: Genome-Wide Association Analysis Identifies 3 Common Variants Predisposing to Brugada Syndrome, a Rare Disease With High Risk of Sudden Cardiac Death (2013) (0)
Heterozygous pathogenic variants in POMC are not responsible for monogenic obesity: implication for MC4R agonist use. (2023) (0)
1901-P: Individual and Longitudinal Effects of Gastric Bypass Surgery on the Circulating Proteome (2020) (0)
Identification and validation of novel genomic CNVs associated with Type 2 diabetes (2009) (0)
Issue Information (2017) (0)
Elucidating the aetiology of Prader-Willi syndrome: deletion of the HBII-85 class of snoRNA is associated with hyperphagia, obesity and hypogonadism (2009) (0)
Hepatic DPP 4 DNA-methylation associates with fatty liver Running title : Epigenetic regulation of hepatic DPP 4 (2016) (0)
Histone deacetylase 9 promoter hypomethylation associated with adipocyte dysfunction is a statin-related metabolic effect (2020) (0)
P582 - Rheumatoid arthritis association with alleles of T-cell receptor α chain is influenced by HLA (1996) (0)
Genetic Variation in the Hepatocyte Nuclear F a c t o r-3 Gene (H N F 3 B) Does Not Contribute to Maturity-Onset Diabetes of the Young in French C a u c a s i a n s (2000) (0)
Genome-Wide Association Identi ﬁ es Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes (2011) (0)
Early epigenetic influence on EGR1, KLF2 and KLF4 transcriptional network associates with alteration of HSCs quiescence (2022) (0)
Next-generation sequencing for identifying new genes in rare genetic diseases: many challenges and a pinch of luck (2013) (0)
Association Sessions (2012) (0)
Single nucleotide polymorphisms in the ghrelin gene in tall obese children (2002) (0)
Metabolic consequences of a new ABCC8/SUR1 gene mutation found in adult type 2 diabetic patients and their lineage (2008) (0)
Periodontitis, Atherosclerotic Cardiovascular Disease and Vitamin D (2009) (0)
Response to the letter to the editor: “HIF-1α protein rather than mRNA as a marker of hypoxia in adipose tissue in obesity,” by Trayhurn et al. (2008) (0)
SESSION III: Risk Factors for Childhood Obesity (2006) (0)
29-OR: High Prevalence of Pathogenic Mutations in Genes Causing Monogenic Diabetes among Patients with Common Type 2 Diabetes (2019) (0)
Contents Vol. 1, 2008 (2008) (0)
High-Throughput Quantitative Screening of Glucose-Stimulated Insulin Secretion and Insulin Content Using Automated MALDI-TOF Mass Spectrometry (2023) (0)
[Something new in the genetics of monogenic obesity and its insights into pathophysiology]. (2020) (0)
The one and only? Gene driving Type2 DM (2008) (0)
DNA damage and the activation of the p53 pathway mediate alterations in metabolic and secretory functions of adipocytes Running title: DNA damage and p53 in obese adipocytes (2016) (0)
Issue Information (2018) (0)
Multi-ancestry genome-wide study in >2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complications (2023) (0)
Acknowledgement to Revierwers (2008) (0)
A crosstalk between E2F1 and GLP-1 signaling pathways modulates insulin secretion (2021) (0)
Edinburgh Research Explorer Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes (2018) (0)
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes (2018) (0)
General regression model: A “model‐free” association test for quantitative traits allowing to test for the underlying genetic model (2019) (0)
糖尿病の遺伝子を探る(7)全ゲノムマッピングによる2型糖尿病遺伝子の網羅的検索 (2003) (0)
Monogenic diabetes (2023) (0)
Biallelic mutations in P4HTM cause syndromic obesity. (2023) (0)
Genomic approach to common human obesity (2002) (0)
The Map3k12 (Dlk)/JNK3 signaling pathway is required for pancreatic beta-cell proliferation during postnatal development (2020) (0)
Variation in the retinoid X receptor gamma gene is associated with type 2 diabetes in sample sets displaying linkage to chromosome 1q (2006) (0)
The discovery of human agouti-induced obesity and its implication for genetic diagnosis. (2022) (0)
Epigenetic changes associated with hyperglycaemia exposure in the longitudinal D.E.S.I.R. cohort (2022) (0)
Management of pregnancy in a patient with congenital hyperinsulinism treated with association of diazoxide/calcium channel blocker (2022) (0)
The HDAC inhibitor trichostatin A impairs pancreatic β-cell function through an epigenome-wide reprogramming (2022) (0)
Evidence ofa Non-MHCSusceptibility LocusinTypeIDiabetes Linked toHLAon Chromosome 6 (1997) (0)
Identification of residues in human melatonin type 2 receptor involved in signaling selectivity or general signal transmission using natural variants (2017) (0)
Author's response to reviews Title: Analysis of the contribution of FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4R genes to obesity in Mexican children Authors: Aurora Mejía-Benítez (amejia@cinvestav.mx) (2012) (0)
Issue Information (2018) (0)
Control of human pancreatic beta cell kinome by GLP-1R biased agonism (2023) (0)
Subject Index Vol. 1, 2008 (2008) (0)
How has the future investment program stimulated research and innovation in health? (2022) (0)
Assignment of trisomic genotypes using the Sequenom iPLEX MALDI TOF assay reveals transmission disequilibrium of two SNP loci in the Type VI Collagen gene cluster associated with CHD in Down's Syndrome. (2009) (0)
Genetic studies in renal diseases (2012) (0)
Reflections on the field of metabolism. (2015) (0)
GeneticLociAssociatedWithC-ReactiveProtein Levels and Risk of Coronary Heart Disease (2017) (0)
Identification of metabolomics biomarkers for type 2 diabetes: triangulating evidence from longitudinal and Mendelian randomization analyses (2020) (0)
Erratum: Genetic variants in LEP, LEPR, and MC4R explain 30% of severe obesity in children from a consanguineous population (2017) (0)
A catalog of genetic loci associated with kidney function from analyses of a million individuals (2019) (0)
[1995 Bouchardat Apollinaire Award. Genetic approach to sugar diabetes]. (1995) (0)
Alu elements implicated in the generation of 9/20 CNV deletions investigated by breakpoint sequencing (2008) (0)
New insight in the genetics of type 2 diabetes and obesity from genome wide associations studies (2009) (0)
Issue information (2019) (0)
Genome-wide Association Study of Change in Fasting Glucose over time in 13,807 non-diabetic European Ancestry Individuals (2019) (0)
Issue Information (2017) (0)
Functional effects of the common SLC30A8 Arg325Trp polymorphism on isolated human pancreatic islets (2009) (0)
Life Changing Decisions due to Etiological Genetic Diagnosis in Families of Children with Maturity Onset Diabetes of the Young (MODY) (2018) (0)
Individual effects of gastric bypass surgery on longitudinal blood protein profiles: an IMI DIRECT study (2019) (0)
EXPRESSION OF THE CARDIOVASCULAR SUSCEPTIBILITY GENE CDKN2B IS UP REGULATED IN OBESITY AND ASSOCIATES WITH FACTORS OF THE METABOLIC SYNDROME: 1D.02 (2011) (0)
[Not Available]. (2015) (0)
Uncovering the genetic causes of common obesity (2004) (0)
Issue Information (2019) (0)
Effect of insulin immunization on glucose tolerance in normal rats. (1987) (0)
Renal dysfunction in HNF 1 α / MODY 3 deficiency scientific reports (2013) (0)
Do our genes make us fat (2003) (0)
Time-of-day-dependent variation of the hepatic transcriptome and metabolome is disrupted in non-alcoholic fatty liver disease patients (2023) (0)
A method for the diagnosis of obesity (2004) (0)
Cdkn 2 a de fi ciency promotes adipose tissue (2018) (0)
A polymorphism in the 5' untranslated region of the human ob gene is associated with lower leptin levels in morbid obesity (1998) (0)
Meetings and Conferences (2008) (0)
Issue Information (2017) (0)
Does CRP Play a Causal Role in the Development of Coronary Heart Disease: Results of a Mendelian Randomisation Experiment Involving 128,935 People (2009) (0)
Replicated association between type 2 diabetes and variants in CAPON revealed by high density linkage disequilibrium mapping on chromosome 1q (2006) (0)
Compound genetic etiology in a patient with a syndrome including diabetes, intellectual deficiency and distichiasis (2022) (0)
β3-adrenoceptor gene variant in obesity and insulin resistance (1996) (0)
Issue Information (2017) (0)
CNVs in Obesity: Uncovering a New Level of Genomic Variation (2009) (0)
Genetic Analysis of Kru¨ppel-Like Zinc Finger 11 Variants in 5864 Danish Individuals: Potential Effect on Insulin Resistance and Modified Signal Transducer and Activator of Transcription-3 Binding by Promoter Variant (cid:1) 1659G > C (2008) (0)
[How useful is an inquiry about family history in type 2 diabetes?]. (1990) (0)
Abstract 13867: A Genome-wide Association Study of Nonsyndromic Mitral Valve Prolapse and Functional Studies of Risk Loci Provide Insight Into Underlying Biological Mechanisms (2014) (0)
Identification of key regions mediating human melatonin type 1 receptor biased signaling revealed by natural variants (2018) (0)
We-W33:1 The genetics of human obesity (2006) (0)
Functional circadian and sleep phenotyping of type 2 diabetes patients with melatonin receptor 2 mutations and controls: a pilot study (2019) (0)
Melanocortin receptor mutations in humans (2006) (0)
Knocking Down CDKN2A in 3D hiPSC-Derived Brown Adipose Progenitors Potentiates Differentiation, Oxidative Metabolism and Browning Process (2023) (0)
Linkage disequilibrium mapping of the type 2 diabetes susceptibility variants on chromosome Iq in European populations (2005) (0)
Genetics of Type 2 Diabetes among Qatari Families (2011) (0)
Diagnostic procedure obesity. (2004) (0)
Epigenetic and Transcriptomic Programming of HSC Quiescence Signaling in Large for Gestational Age Neonates (2022) (0)
Meta-Analysis of Maternal Prenatal Smoking GFI1-Locus and Cardio-Metabolic Phenotypes in Adults (2018) (0)
Placental prolactin family levels are modified during gestation in the diabetic rat (2014) (0)
Common variants near BDNF and SH2B1 show nominal evidence of association with snacking behavior in European populations (2013) (0)
3P-0901 Single-nucleotide polymorphism (SNP) haplotypes in the adiponectin (APM1) gene with relation to serum adiponectin, body fat distribution, and the severity of atherosclerosis in elderly women (2003) (0)
Dysfunctionof lipid sensorGPR120 leads to obesity in both mouse and human (2020) (0)
[Genetic risk of non-insulin-dependent diabetes]. (1998) (0)
Several gene polymorphisms but not FTO variant modulate resting energy expenditure and fat-induced thermogenesis in obese subjects: The NUGENOB Study (2008) (0)
Positional candidate gene selection on chromosome 1q using bioinformatics and large scale association analysis (2005) (0)
Genetics of non-insulin-dependent diabetes mellitus: from genes to the disease. (1995) (0)
Linkage studies of the Type 2 diabetes susceptibility locus on chromosome 1q: Combined analysis of 1200 UK and French affected sibpairs (2002) (0)
Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps (2018) (0)
Paraoxonase serum concentration, enzyme activity and genotype distribution are not related to diabetes (1995) (0)
Does Type 2 diabetes increase the risk of developing cancer (2013) (0)
A Prospective Metabonomics Analysis Reveals New Pathways Involved In T2D Development (2014) (0)
A rare human variant that disrupts GPR10 signalling causes weight gain in mice (2023) (0)
Issue Information (2019) (0)
MODY sub-types in a panel of Spanish families with early onset diabetes mellitus , and to assess phenotypic differences in patients with the different subtypes of MODY . Research design and methods Subjects (2000) (0)
Iconography : Mutation screening of the PPAR agene in type 2 diabetes associated with coronary heart disease (2008) (0)
Frequency of single nucleotide polymorphisms in the GHRH receptor gene in short children (2004) (0)
Beta 3-adrenoceptor gene variant in obesity and insulin resistance. (1996) (0)
Method of diagnosis of obesity GAD2-Obesity (2006) (0)
Genetic polymorphisms explain variation in the ability to regulate fat oxidation (2007) (0)
Issue Information (2017) (0)
[What have we learned thanks to genetics in type II diabetes and its complications?]. (1999) (0)
Large-scale follow-up study does not confirm putative association signals in the NOS1AP and PKLR gene regions on chromosome 1q with type 2 diabetes (2008) (0)
Loss-of-function mutations in ADCY3 cause monogenic severe obesity (2018) (0)
Pluripotent Stem Cells as a Potential Tool for Disease Modelling and Cell Therapy in Diabetes (2014) (0)
W11-IS-001 From genome scans to genes predisposing to familial metabolic syndrome and diabesity (2005) (0)
Issue Information (2017) (0)
Elucidating the aetiology of Prader-Willi syndrome (2009) (0)
University of Southern Denmark Genetic Discrimination Between LADA and Childhood-Onset Type 1 Diabetes Within the MHC Mishra, (2020) (0)
High morbidity and mortality in children with untreated congenital deficiency of leptin or its receptor (2023) (0)
Genetic relationships and causality between overall and central adiposity and breast, prostate, lung and colorectal cancer (2022) (0)
Epigenetic regulation of hepatic DPP4 (2017) (0)
Bi-directional Mendelian randomization and multi-phenotype GWAS show causality and shared pathophysiology between depression and type 2 diabetes (2022) (0)
Identification of biomarkers for glycaemic deterioration in type 2 diabetes (2023) (0)
Epigenetics of PNLIPRP1 in human pancreas reveals a molecular path between type 2 diabetes and pancreatic cancer (2022) (0)
O53 La voie des kynurénines est dérégulée dans l’obésité (2015) (0)

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