Phillip D. Zamore | Academic Influence

Phillip D. Zamore's AcademicInfluence.com Rankings

Phillip D. Zamore

Biology

#4185

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#6278

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Molecular Biology

#499

World Rank

#510

Historical Rank

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Biology

Phillip D. Zamore's Degrees

Bachelors Biology University of California, San Diego

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Why Is Phillip D. Zamore Influential?

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According to Wikipedia, Phillip D. Zamore is an American molecular biologist and developed the first in vitro system for studying the mechanism of RNA interference . He is the Gretchen Stone Cook Professor of Biomedical Sciences and Professor of Biochemistry and Molecular Pharmacology at University of Massachusetts Chan Medical School, located in Worcester, Massachusetts. Zamore is the chair of the RNA Therapeutics Institute at UMass Chan Medical School, established in 2009, and has been a Howard Hughes Medical Institute Investigator since 2008.

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Phillip D. Zamore's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Asymmetry in the Assembly of the RNAi Enzyme Complex (2003) (2944)
A Cellular Function for the RNA-Interference Enzyme Dicer in the Maturation of the let-7 Small Temporal RNA (2001) (2850)
RNAi Double-Stranded RNA Directs the ATP-Dependent Cleavage of mRNA at 21 to 23 Nucleotide Intervals (2000) (2781)
Small silencing RNAs: an expanding universe (2009) (2262)
A microRNA in a Multiple-Turnover RNAi Enzyme Complex (2002) (2135)
RNA Interference (2000) (1539)
A Distinct Small RNA Pathway Silences Selfish Genetic Elements in the Germline (2006) (1288)
Ribo-gnome: The Big World of Small RNAs (2005) (1287)
Passenger-Strand Cleavage Facilitates Assembly of siRNA into Ago2-Containing RNAi Enzyme Complexes (2005) (1147)
ATP Requirements and Small Interfering RNA Structure in the RNA Interference Pathway (2001) (1107)
Diversifying microRNA sequence and function (2013) (1081)
Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals (2010) (1025)
A biochemical framework for RNA silencing in plants. (2003) (1017)
Perspective: machines for RNAi. (2005) (974)
Targeted mRNA degradation by double-stranded RNA in vitro. (1999) (930)
microPrimer: the biogenesis and function of microRNA (2005) (828)
MicroRNA control of PHABULOSA in leaf development: importance of pairing to the microRNA 5′ region (2004) (686)
Endogenous siRNAs Derived from Transposons and mRNAs in Drosophila Somatic Cells (2008) (682)
A Protein Sensor for siRNA Asymmetry (2004) (636)
PIWI-interacting RNAs: small RNAs with big functions (2018) (598)
Normal microRNA Maturation and Germ-Line Stem Cell Maintenance Requires Loquacious, a Double-Stranded RNA-Binding Domain Protein (2005) (573)
RNAi: nature abhors a double-strand. (2002) (552)
Cloning and domain structure of the mammalian splicing factor U2AF (1992) (540)
Kinetic analysis of the RNAi enzyme complex (2004) (540)
Target RNA–Directed Trimming and Tailing of Small Silencing RNAs (2010) (534)
Collapse of Germline piRNAs in the Absence of Argonaute3 Reveals Somatic piRNAs in Flies (2009) (532)
The Drosophila RNA Methyltransferase, DmHen1, Modifies Germline piRNAs and Single-Stranded siRNAs in RISC (2007) (525)
Sequence-Specific Inhibition of Small RNA Function (2004) (516)
Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways. (2002) (493)
Modular Recognition of RNA by a Human Pumilio-Homology Domain (2002) (469)
Drosophila microRNAs Are Sorted into Functionally Distinct Argonaute Complexes after Production by Dicer-1 (2007) (447)
A factor, U2AF, is required for U2 snRNP binding and splicing complex assembly (1988) (445)
RISC Assembly Defects in the Drosophila RNAi Mutant armitage (2004) (416)
RNA interference: listening to the sound of silence (2001) (405)
Translational regulation in development (1995) (402)
Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits (2007) (401)
Sorting of Drosophila Small Silencing RNAs (2007) (397)
The Drosophila HP1 Homolog Rhino Is Required for Transposon Silencing and piRNA Production by Dual-Strand Clusters (2009) (376)
Ancient Pathways Programmed by Small RNAs (2002) (362)
Sorting of Drosophila small silencing RNAs partitions microRNA* strands into the RNA interference pathway. (2010) (342)
The Pumilio protein binds RNA through a conserved domain that defines a new class of RNA-binding proteins. (1997) (337)
Identification, purification, and biochemical characterization of U2 small nuclear ribonucleoprotein auxiliary factor. (1989) (334)
Argonaute Divides Its RNA Guide into Domains with Distinct Functions and RNA-Binding Properties (2012) (330)
An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes. (2013) (313)
The protein Sex-lethal antagonizes the splicing factor U2AF to regulate alternative splicing of transformer pre-mRNA (1993) (308)
MicroRNA-33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis. (2015) (301)
The RNA-Induced Silencing Complex Is a Mg2+-Dependent Endonuclease (2004) (293)
Designing siRNA That Distinguish between Genes That Differ by a Single Nucleotide (2006) (283)
piRNA-guided transposon cleavage initiates Zucchini-dependent, phased piRNA production (2015) (280)
Five siRNAs Targeting Three SNPs May Provide Therapy for Three-Quarters of Huntington's Disease Patients (2009) (248)
Crystal structure of a Pumilio homology domain. (2001) (233)
Deep annotation of Drosophila melanogaster microRNAs yields insights into their processing, modification, and emergence. (2011) (232)
Adaptation to P Element Transposon Invasion in Drosophila melanogaster (2011) (222)
Single-Molecule Imaging Reveals that Argonaute Reshapes the Binding Properties of Its Nucleic Acid Guides (2015) (219)
UAP56 Couples piRNA Clusters to the Perinuclear Transposon Silencing Machinery (2012) (209)
Cloning and intracellular localization of the U2 small nuclear ribonucleoprotein auxiliary factor small subunit. (1992) (200)
Long-term, efficient inhibition of microRNA function in mice using rAAV vectors (2012) (198)
Pan-arthropod analysis reveals somatic piRNAs as an ancestral defence against transposable elements (2017) (190)
Argonaute Loading Improves the 5′ Precision of Both MicroRNAs and Their miRNA∗ Strands in Flies (2008) (185)
The HP1 Homolog Rhino Anchors a Nuclear Complex that Suppresses piRNA Precursor Splicing (2014) (179)
Selective silencing by RNAi of a dominant allele that causes amyotrophic lateral sclerosis (2003) (177)
A role for microRNAs in the Drosophila circadian clock. (2009) (173)
Heterotypic piRNA Ping-Pong requires qin, a protein with both E3 ligase and Tudor domains. (2011) (163)
Dicer Partner Proteins Tune the Length of Mature miRNAs in Flies and Mammals (2012) (162)
A single Argonaute protein mediates both transcriptional and posttranscriptional silencing in Schizosaccharomyces pombe. (2004) (158)
The 3′-to-5′ Exoribonuclease Nibbler Shapes the 3′ Ends of MicroRNAs Bound to Drosophila Argonaute1 (2011) (155)
Beginning to understand microRNA function (2007) (154)
MicroRNA therapeutics (2011) (151)
MicroRNA Biogenesis: Drosha Can't Cut It without a Partner (2005) (148)
MicroRNA-regulated, Systemically Delivered rAAV9: A Step Closer to CNS-restricted Transgene Expression (2010) (146)
In vitro analysis of RNA interference in Drosophila melanogaster. (2003) (137)
Phosphate and R2D2 restrict the substrate specificity of Dicer-2, an ATP-driven ribonuclease. (2011) (133)
Argonaute protein identity and pairing geometry determine cooperativity in mammalian RNA silencing. (2011) (127)
A Single Mechanism of Biogenesis, Initiated and Directed by PIWI Proteins, Explains piRNA Production in Most Animals. (2018) (124)
Strand-specific libraries for high throughput RNA sequencing (RNA-Seq) prepared without poly(A) selection (2012) (124)
A CCHC metal‐binding domain in Nanos is essential for translational regulation (1997) (120)
piPipes: a set of pipelines for piRNA and transposon analysis via small RNA-seq, RNA-seq, degradome- and CAGE-seq, ChIP-seq and genomic DNA sequencing (2014) (106)
Slicing and Binding by Ago3 or Aub Trigger Piwi-Bound piRNA Production by Distinct Mechanisms. (2015) (102)
Sustained miRNA-mediated Knockdown of Mutant AAT With Simultaneous Augmentation of Wild-type AAT Has Minimal Effect on Global Liver miRNA Profiles (2012) (102)
MicroRNAs: Regulating a Change of Heart (2009) (101)
Elimination of PCR duplicates in RNA-seq and small RNA-seq using unique molecular identifiers (2018) (99)
Cnidarian microRNAs frequently regulate targets by cleavage (2014) (99)
Design and delivery of antisense oligonucleotides to block microRNA function in cultured Drosophila and human cells (2008) (97)
The PUMILIO-RNA interaction: a single RNA-binding domain monomer recognizes a bipartite target sequence. (1999) (96)
The initial uridine of primary piRNAs does not create the tenth adenine that Is the hallmark of secondary piRNAs. (2014) (94)
Argonaute proteins (2011) (93)
Why do miRNAs live in the miRNP? (2002) (87)
Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo (2018) (86)
Small silencing RNAs (2007) (85)
Plant RNAi: How aViral Silencing Suppressor Inactivates siRNA (2004) (80)
High-Throughput Analysis Reveals Rules for Target RNA Binding and Cleavage by AGO2. (2019) (75)
Rethinking the Microprocessor (2006) (74)
RNA annealing activity is intrinsically associated with U2AF. (1993) (61)
The Evolutionarily Conserved piRNA-producing Locus pi6 Is Required for Male Mouse Fertility (2020) (60)
Competitive endogenous RNAs cannot alter microRNA function in vivo. (2014) (59)
RNA Interference: Big Applause for Silencing in Stockholm (2006) (59)
The genome of the Hi5 germ cell line from Trichoplusia ni, an agricultural pest and novel model for small RNA biology (2018) (58)
Dicer Partner Proteins Tune the Length of Mature miRNAs in Flies and Mammals (2012) (57)
A 5′-uridine amplifies miRNA/miRNA* asymmetry in Drosophila by promoting RNA-induced silencing complex formation (2011) (56)
Target RNA-directed tailing and trimming purifies the sorting of endo-siRNAs between the two Drosophila Argonaute proteins. (2011) (55)
Welcome to Silence (2010) (52)
Evolutionarily Conserved Pachytene piRNA Loci are Highly Divergent among Modern Humans (2019) (45)
Rapid and specific purification of Argonaute-small RNA complexes from crude cell lysates. (2013) (44)
Thermus thermophilus Argonaute Functions in the Completion of DNA Replication (2020) (44)
Somatic piRNA biogenesis (2010) (43)
The RNA-binding ATPase, Armitage, Couples piRNA Amplification in Nuage to Phased piRNA Production on Mitochondria (2018) (43)
RNA silencing: Genomic defence with a slice of pi (2007) (42)
Inorganic phosphate blocks binding of pre‐miRNA to Dicer‐2 via its PAZ domain (2014) (40)
Thirty-three years later, a glimpse at the ribonuclease III active site. (2001) (38)
Linking SNPs to CAG repeat length in Huntington's disease patients (2008) (38)
siRNAs knock down hepatitis (2003) (37)
Rapid Screening for CRISPR-Directed Editing of the Drosophila Genome Using white Coconversion (2016) (35)
Assessing long-distance RNA sequence connectivity via RNA-templated DNA–DNA ligation (2015) (28)
Biochemical dissection of RNA silencing in plants. (2004) (26)
Tailor: a computational framework for detecting non-templated tailing of small silencing RNAs (2015) (25)
Huntington's disease: Silencing a brutal killer (2009) (24)
Antisense piRNA amplification, but not piRNA production or nuage assembly, requires the Tudor‐domain protein Qin (2014) (24)
Cas9-mediated allelic exchange repairs compound heterozygous recessive mutations in mice (2018) (23)
Maelstrom Represses Canonical Polymerase II Transcription within Bi-Directional piRNA Clusters in Drosophila melanogaster (2018) (23)
RNA binding: βS and basics (1990) (22)
Defining piRNA primary transcripts (2013) (21)
High-Throughput Sequencing Analysis of Post-Liver Transplantation HCV E2 Glycoprotein Evolution in the Presence and Absence of Neutralizing Monoclonal Antibody (2014) (21)
Pitfalls of mapping high-throughput sequencing data to repetitive sequences: Piwi's genomic targets still not identified. (2015) (21)
An automated Bayesian pipeline for rapid analysis of single-molecule binding data (2018) (20)
SnapShot: Fly piRNAs, PIWI Proteins, and the Ping-Pong Cycle (2009) (20)
Comparative analysis of the plant mRNA-destabilizing element, DST, in mammalian and tobacco cells (2002) (19)
Transcriptome Profiling of Neovascularized Corneas Reveals miR-204 as a Multi-target Biotherapy Deliverable by rAAVs (2017) (18)
Small RNA-Directed Silencing: The Fly Finds Its Inner Fission Yeast? (2013) (17)
Isolation of Drosophila melanogaster Testes (2011) (15)
SnapShot: Mouse piRNAs, PIWI Proteins, and the Ping-Pong Cycle (2009) (14)
Effective and Accurate Gene Silencing by a Recombinant AAV-Compatible MicroRNA Scaffold. (2019) (14)
Terminal modification, sequence, length, and PIWI-protein identity determine piRNA stability. (2021) (14)
Small methyltransferase RlmH assembles a composite active site to methylate a ribosomal pseudouridine (2017) (12)
Structural Basis of MicroRNA Biogenesis by Dicer-1 and Its Partner Protein Loqs-PB (2022) (11)
Increased Steady-State Mutant Huntingtin mRNA in Huntington's Disease Brain. (2013) (11)
Measuring the rates of transcriptional elongation in the female Drosophila melanogaster germ line by nuclear run-on. (2006) (10)
Long first exons and epigenetic marks distinguish conserved pachytene piRNA clusters from other mammalian genes (2021) (10)
Small RNAs, big biology: biochemical studies of RNA interference (2003) (10)
RNA Interference and Small RNA Analysis. (2019) (10)
Wandering eye for RNAi. (2008) (9)
GTSF1 accelerates target RNA cleavage by PIWI-clade Argonaute proteins (2022) (9)
Diseases caused by different mutations in the two alleles of a gene are treated in mice by Cas-9-induced allelic exchange. (2018) (9)
Defining the functions of PIWI-interacting RNAs (2021) (9)
Analysis of Small RNAs by Northern Hybridization. (2018) (9)
Drosophila development: Homeodomains and translational control (1996) (8)
Single-Molecule Imaging Reveals that Argonaute Reshapes the Binding Properties of Its Nucleic Acid Guides (2016) (8)
The genome of Trichoplusia ni, an agricultural pest and novel model for small RNA biology (2017) (7)
Plant RNA interference in vitro. (2004) (7)
A universal small molecule, inorganic phosphate, restricts the substrate specificity of Dicer-2 in small RNA biogenesis (2014) (7)
Small RNA Silencing Pathways (2007) (7)
Preparation of Antisense Oligonucleotides to Inhibit miRNA Function. (2018) (6)
Preparation of siRNA Duplexes. (2019) (5)
Pan-arthropod analysis reveals somatic piRNAs as an ancestral TE defence (2017) (5)
High-throughput biochemical profiling reveals functional adaptation of a bacterial Argonaute. (2022) (5)
Gene expression. RNA binding: beta s and basics. (1990) (4)
Faculty Opinions recommendation of Uncoupling of RNAi from active translation in mammalian cells. (2004) (4)
Summary microPrimer : the biogenesis and function of microRNA (4)
An Evolutionarily Conserved piRNA-producing Locus Required for Male Mouse Fertility (2018) (4)
Loquacious, a Dicer Partner Protein, Functions in Both the MicroRNA and siRNA Pathways (2012) (4)
Efficient Homology-Directed Repair with Circular Single-Stranded DNA Donors (2022) (4)
The conserved zinc-finger protein GTSF1 helps PIWI proteins achieve their full catalytic potential (2021) (4)
RNAi in Mammalian Cells by siRNA Duplex Transfection. (2019) (3)
MicroRNAs tame CRISPR–Cas9 (2019) (3)
Tetrazine-Ligated CRISPR sgRNAs for Efficient Genome Editing (2022) (3)
Inhibiting miRNA Function by Antisense Oligonucleotides in Drosophila S2 Cells. (2018) (3)
A DNA-guided Argonaute Protein Functions in DNA Replication in Thermus thermophilus (2019) (3)
RNAi in Drosophila S2 Cells by dsRNA Soaking. (2019) (3)
Inhibiting miRNA Function by Antisense Oligonucleotides in Cultured Mammalian Cells. (2018) (3)
Preparation of dsRNAs for RNAi by In Vitro Transcription. (2019) (3)
PIWI-interacting RNAs: small RNAs with big functions (2018) (3)
RNAi in Drosophila S2 Cells by siRNA Duplex or dsRNA Transfection. (2019) (3)
The transcription factor TCFL5 responds to A MYB to elaborate the male meiotic program in mice. (2022) (3)
Nucleus and gene expression. (2004) (2)
Terminal Modification, Sequence, and Length Determine Small RNA Stability in Animals (2020) (2)
A-MYB/TCFL5 regulatory architecture ensures the production of pachytene piRNAs in placental mammals (2022) (2)
Cloning and intracellular localization of the U 2 small nuclear ribonucleoprotein auxiliary factor small subunit ( spllcing / spliceosome / RNA binding / arginine , serine rich / cofled body ) (2)
Evolutionarily conserved pachytene piRNA loci are highly divergent among modern humans (2019) (2)
Relaxed targeting rules allow PIWI-clade Argonaute proteins to silence ever-mutating transposons (2022) (2)
Molecular biology: Rhino gives voice to silent chromatin (2017) (2)
Principles and pitfalls of high-throughput analysis of microRNA-binding thermodynamics and kinetics by RNA Bind-n-Seq (2022) (1)
To Degrade a MicroRNA, Destroy Its Argonaute Protein. (2021) (1)
PIWI Proteins Act at Multiple Steps in the Production of Their Own Guides (2018) (1)
Author response: Assessing long-distance RNA sequence connectivity via RNA-templated DNA–DNA ligation (2014) (1)
A Single Mechanism of Biogenesis, Initiated and Directed by PIWI Proteins, Explains piRNA Production in Most Animals (2018) (1)
Crystal Structure of a Pumilio Homology Domain protein acts with DmPUM to produce a complementary (2001) (1)
rAAV-based compositions and methods (2016) (0)
What fruit flies teach us about RNA silencing. (2009) (0)
Mediators specific RNA interference RNA sequences (2001) (0)
Invited Internal Speakers Mixed signals ; translational quality control is critical for bacterial responses to amino acid stress (0)
Assessing the 5 A Day Message on Vegetable Consumption of Head Start Children (1999) (0)
Changes in viral loads and epitope sequence distributions in placebo subjects. (2014) (0)
Faculty Opinions recommendation of R2D2, a bridge between the initiation and effector steps of the Drosophila RNAi pathway. (2003) (0)
Crystal Structure of RlmH in Complex with S-Adenosylmethionine (2017) (0)
Faculty Opinions recommendation of Crystal structure of Argonaute and its implications for RISC slicer activity. (2004) (0)
Pan-arthropod analysis reveals somatic piRNAs as an ancestral defence against transposable elements (2017) (0)
Barringhaus and Zamore MicroRNAs : Regulating a Change of Heart 2221 (2009) (0)
Chinese scientists and US leadership in the life sciences (2019) (0)
570. Transient Reconstitution of Cas9 Protein for Safer Gene Editing In Vivo - A Ferry Tale Starring rAAV Capsid (2016) (0)
Translational control and rna localization in drosophila (1998) (0)
Faculty Opinions recommendation of Size selective recognition of siRNA by an RNA silencing suppressor. (2004) (0)
Rna interference mediators specifics of rna sequences. (2001) (0)
Faculty Opinions recommendation of The nuclear RNase III Drosha initiates microRNA processing. (2003) (0)
One small step for worms, one giant leap for small RNAs (2020) (0)
Methods and compositions for improving the effectiveness and specificity of fnai (2004) (0)
CRYSTAL STRUCTURE OF THE PUMILIO-HOMOLOGY DOMAIN FROM HUMAN PUMILIO1 IN COMPLEX WITH NRE2-10 RNA (2002) (0)
An automated Bayesian pipeline for rapid analysis of single-molecule binding data (2019) (0)
Faculty Opinions recommendation of Tre1, a G protein-coupled receptor, directs transepithelial migration of Drosophila germ cells. (2004) (0)
MicroRNAs tame CRISPR–Cas9 (2019) (0)
Mediators of rns interference that are rns sequence-specific (2001) (0)
The testis-specific transcription factor TCFL5 responds to A-MYB to elaborate the male meiotic program in placental mammals (2021) (0)
EXOn 25 EXOn 1 mutant EEP 2 P normal FEEF 2 (2017) (0)
Small methyltransferase RlmH assembles a composite active site to methylate a ribosomal pseudouridine (2017) (0)
CRYSTAL STRUCTURE OF THE PUMILIO-HOMOLOGY DOMAIN FROM HUMAN PUMILIO1 IN COMPLEX WITH NRE1-14 RNA (2002) (0)
Crystal Structure of RlmH in Complex with Sinefungin (2017) (0)
Biochemical mechanisms of mammalian pre-mRNA splicing (1987) (0)
RNA: methods and protocols — a new series (2012) (0)
Editorial to Silence (2010) (0)
Recombinant adeno-associated virus-based microRNA therapeutics for cancer (2014) (0)
SMALL RNA DIVERSITY AND FUNCTION (2007) (0)
Elimination of PCR duplicates in RNA-seq and small RNA-seq using unique molecular identifiers (2018) (0)
Abstract IA12: Long-term, efficient inhibition of miRNA function in mice using Tough Decoys delivered by Adeno-associated virus vectors (2012) (0)
739. rAAV Delivered MicroRNA Therapeutics Towards Efficacious Treatment of Corneal Neovascularization (2016) (0)
Long first exons and epigenetic marks distinguish conserved pachytene piRNA clusters from other mammalian genes (2021) (0)
Nucleus and gene expression Editorial overview (2009) (0)
Startups on the menu: Alnylam (2014) (0)
Nucleus and gene expression Editorial overview Elisa Izaurralde and (2009) (0)
GTSF1 accelerates target RNA cleavage by PIWI-clade Argonaute proteins (2022) (0)
RNA interference to treat disorders related to the gain function (2004) (0)
ARNi : la nature a horreur des doubles brins : ARN: Small world? (2002) (0)
Author response: The genome of the Hi5 germ cell line from Trichoplusia ni, an agricultural pest and novel model for small RNA biology (2017) (0)
Rna localization and pattern formation in drosophila (1997) (0)
A method of producing knockdown cells or organisms knockdown using RNA sequence-specific mediators of RNA interference and uses thereof (2001) (0)
Faculty Opinions recommendation of RNA interference targeting Fas protects mice from fulminant hepatitis. (2003) (0)

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