Pierre Gönczy
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Biology
Pierre Gönczy's Degrees
- PhD Cell Biology University of Geneva
- Masters Biochemistry University of Geneva
Why Is Pierre Gönczy Influential?
(Suggest an Edit or Addition)According to Wikipedia, Pierre Gönczy is a Swiss and Italian cell and developmental biologist. His research focuses on centriole biology and asymmetric cell division. He is currently professor at École Polytechnique Fédérale de Lausanne , where he directs the Laboratory of Cell and Developmental Biology.
Pierre Gönczy's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans (2005) (912)
- Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III (2000) (906)
- Mechanisms of asymmetric cell division: flies and worms pave the way (2008) (503)
- Polarity controls forces governing asymmetric spindle positioning in the Caenorhabditis elegans embryo (2001) (498)
- Cytoplasmic Dynein Is Required for Distinct Aspects of Mtoc Positioning, Including Centrosome Separation, in the One Cell Stage Caenorhabditis elegans Embryo (1999) (451)
- A single amino acid can determine the DNA binding specificity of homeodomain proteins (1989) (446)
- SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells (2005) (387)
- Toward a molecular genetic analysis of spermatogenesis in Drosophila melanogaster: characterization of male-sterile mutants generated by single P element mutagenesis. (1993) (381)
- Regulated HsSAS-6 levels ensure formation of a single procentriole per centriole during the centrosome duplication cycle. (2007) (332)
- Mechanisms of nuclear positioning. (1998) (322)
- Structural Basis of the 9-Fold Symmetry of Centrioles (2011) (320)
- Towards a molecular architecture of centriole assembly (2012) (278)
- Coupling of cortical dynein and Gα proteins mediates spindle positioning in Caenorhabditis elegans (2007) (257)
- Translation of Polarity Cues into Asymmetric Spindle Positioning in Caenorhabditis elegans Embryos (2003) (255)
- Overly Long Centrioles and Defective Cell Division upon Excess of the SAS-4-Related Protein CPAP (2009) (249)
- The germ line regulates somatic cyst cell proliferation and fate during Drosophila spermatogenesis. (1996) (223)
- SAS-4 is essential for centrosome duplication in C elegans and is recruited to daughter centrioles once per cell cycle. (2003) (222)
- The kinetically dominant assembly pathway for centrosomal asters in Caenorhabditis elegans is γ-tubulin dependent (2002) (216)
- Sequential Protein Recruitment in C. elegans Centriole Formation (2006) (206)
- Cortical dynein is critical for proper spindle positioning in human cells (2012) (205)
- Cytoskeletal Regulation by the Nedd8 Ubiquitin-Like Protein Modification Pathway (2002) (200)
- bag-of-marbles and benign gonial cell neoplasm act in the germline to restrict proliferation during Drosophila spermatogenesis. (1997) (196)
- RIC-8 Is Required for GPR-1/2-Dependent Gα Function during Asymmetric Division of C. elegans Embryos (2004) (192)
- Asymmetric cell division and axis formation in the embryo. (2005) (187)
- Dissection of Cell Division Processes in the One Cell Stage Caenorhabditis elegans Embryo by Mutational Analysis (1999) (185)
- Differential Activation of the DNA Replication Checkpoint Contributes to Asynchrony of Cell Division in C. elegans Embryos (2003) (180)
- Centrosomes and cancer: revisiting a long-standing relationship (2015) (176)
- Mechanisms of procentriole formation. (2008) (173)
- Resolution Doubling in 3D-STORM Imaging through Improved Buffers (2013) (169)
- Centriolar SAS-5 is required for centrosome duplication in C. elegans (2004) (167)
- Polarity establishment, asymmetric division and segregation of fate determinants in early C. elegans embryos. (2014) (158)
- The arithmetic of centrosome biogenesis (2004) (156)
- The SCF–FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication (2011) (155)
- Mechanisms of spindle positioning: cortical force generators in the limelight. (2013) (154)
- TAC-1 and ZYG-9 Form a Complex that Promotes Microtubule Assembly in C. elegans Embryos (2003) (142)
- zyg-11 and cul-2 regulate progression through meiosis II and polarity establishment in C. elegans (2004) (135)
- Cyk-4 (2000) (132)
- punt and schnurri regulate a somatically derived signal that restricts proliferation of committed progenitors in the germline. (1997) (128)
- Probing spermatogenesis in Drosophila with P-element enhancer detectors. (1992) (120)
- Native Architecture of the Centriole Proximal Region Reveals Features Underlying Its 9-Fold Radial Symmetry (2013) (112)
- NuMA-related LIN-5, ASPM-1, calmodulin and dynein promote meiotic spindle rotation independently of cortical LIN-5/GPR/Gα (2009) (110)
- Coupling the cell cycle to development (2009) (109)
- Spindle positioning in human cells relies on proper centriole formation and on the microcephaly proteins CPAP and STIL (2011) (103)
- Simple buffers for 3D STORM microscopy (2013) (102)
- Mechanisms of spindle positioning: focus on flies and worms. (2002) (100)
- Selective Chemical Crosslinking Reveals a Cep57-Cep63-Cep152 Centrosomal Complex (2013) (97)
- zyg-8, a gene required for spindle positioning in C. elegans, encodes a doublecortin-related kinase that promotes microtubule assembly. (2001) (97)
- Centrosomes promote timely mitotic entry in C. elegans embryos. (2007) (91)
- Discovering regulators of centriole biogenesis through siRNA-based functional genomics in human cells. (2013) (89)
- NuMA phosphorylation by CDK1 couples mitotic progression with cortical dynein function (2013) (89)
- fumble encodes a pantothenate kinase homolog required for proper mitosis and meiosis in Drosophila melanogaster. (2001) (85)
- Cartwheel Architecture of Trichonympha Basal Body (2012) (83)
- Cortical localization of the Gα protein GPA-16 requires RIC-8 function during C. elegans asymmetric cell division (2005) (80)
- High-speed photothermal off-resonance atomic force microscopy reveals assembly routes of centriolar scaffold protein SAS-6 (2018) (79)
- lis-1 is required for dynein-dependent cell division processes in C. elegans embryos (2004) (77)
- PLK-1 asymmetry contributes to asynchronous cell division of C. elegans embryos (2008) (76)
- Mechanisms of HsSAS-6 assembly promoting centriole formation in human cells (2014) (75)
- Centriolar CPAP/SAS-4 Imparts Slow Processive Microtubule Growth (2016) (73)
- Centriole Biogenesis: From Identifying the Characters to Understanding the Plot. (2017) (72)
- Centrosome duplication and nematodes: recent insights from an old relationship. (2005) (71)
- Cell-free reconstitution reveals centriole cartwheel assembly mechanisms (2017) (69)
- SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture (2016) (67)
- KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification (2016) (66)
- A missense mutation in the PISA domain of HsSAS-6 causes autosomal recessive primary microcephaly in a large consanguineous Pakistani family. (2014) (63)
- MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression (2013) (63)
- NuMA interacts with phosphoinositides and links the mitotic spindle with the plasma membrane (2014) (62)
- Centriole assembly at a glance (2019) (61)
- Phosphorylation of SAS-6 by ZYG-1 is critical for centriole formation in C. elegans embryos. (2009) (61)
- Caenorhabditis elegans centriolar protein SAS-6 forms a spiral that is consistent with imparting a ninefold symmetry (2013) (59)
- Multicolor single particle reconstruction of protein complexes (2018) (59)
- roughex is a dose-dependent regulator of the second meiotic division during Drosophila spermatogenesis (1994) (58)
- Analysis of centriole elimination during C. elegans oogenesis (2012) (57)
- Discovery of a Selective Aurora A Kinase Inhibitor by Virtual Screening. (2016) (55)
- Cortical domains and the mechanisms of asymmetric cell division. (1996) (51)
- PP2A phosphatase acts upon SAS-5 to ensure centriole formation in C. elegans embryos. (2011) (51)
- Identification of Chlamydomonas Central Core Centriolar Proteins Reveals a Role for Human WDR90 in Ciliogenesis (2017) (45)
- The Rise of the Cartwheel: Seeding the Centriole Organelle (2018) (43)
- Aurora A kinase regulates proper spindle positioning in C. elegans and in human cells (2016) (43)
- Dynein Transmits Polarized Actomyosin Cortical Flows to Promote Centrosome Separation. (2016) (37)
- OOC-3, a novel putative transmembrane protein required for establishment of cortical domains and spindle orientation in the P(1) blastomere of C. elegans embryos. (2000) (37)
- Distinct mechanisms eliminate mother and daughter centrioles in meiosis of starfish oocytes (2016) (37)
- Inherited immunodeficiency with a defect in a major histocompatibility complex class II promoter-binding protein differs in the chromatin structure of the HLA-DRA gene (1989) (36)
- Aurora A depletion reveals centrosome-independent polarization mechanism in Caenorhabditis elegans (2019) (35)
- The Caenorhabditis elegans protein SAS-5 forms large oligomeric assemblies critical for centriole formation (2015) (35)
- ZYG-9, TAC-1 and ZYG-8 together ensure correct microtubule function throughout the cell cycle of C. elegans embryos (2007) (35)
- Homogeneous multifocal excitation for high-throughput super-resolution imaging (2020) (35)
- Regulation of cortical contractility and spindle positioning by the protein phosphatase 6 PPH-6 in one-cell stage C. elegans embryos (2010) (34)
- Zika virus causes supernumerary foci with centriolar proteins and impaired spindle positioning (2017) (32)
- Regulation of cortical contractility and spindle positioning by the protein phosphatase 6 PPH-6 in one-cell stage C. elegans embryos (2016) (31)
- Stereotyped distribution of midbody remnants in early C. elegans embryos requires cell death genes and is dispensable for development (2013) (31)
- Centrosomes back in the limelight (2014) (31)
- Correlative multicolor 3D SIM and STORM microscopy. (2014) (30)
- Uncovering the balance of forces driving microtubule aster migration in C. elegans zygotes (2018) (30)
- The Human Centriolar Protein CEP135 Contains a Two-Stranded Coiled-Coil Domain Critical for Microtubule Binding. (2016) (29)
- Paternally contributed centrioles exhibit exceptional persistence in C. elegans embryos (2015) (29)
- Polarity mediates asymmetric trafficking of the Gβ heterotrimeric G-protein subunit GPB-1 in C. elegans embryos (2011) (27)
- Nuclear Envelope: Torn Apart at Mitosis (2002) (23)
- The nucleoporin Nup205/NPP-3 is lost near centrosomes at mitotic onset and can modulate the timing of this process in Caenorhabditis elegans embryos (2012) (21)
- Centrosomes: Hooked on the Nucleus (2004) (20)
- Spindle positioning during the asymmetric first cell division of Caenorhabditis elegans embryos. (2001) (19)
- PI(4,5)P2 forms dynamic cortical structures and directs actin distribution as well as polarity in Caenorhabditis elegans embryos (2018) (19)
- Tissue- and sex-specific small RNAomes reveal sex differences in response to the environment (2018) (18)
- Reconstruction From Multiple Particles for 3D Isotropic Resolution in Fluorescence Microscopy (2018) (18)
- NuMA phosphorylation dictates dynein-dependent spindle positioning (2013) (16)
- Structural Determinants Underlying the Temperature-sensitive Nature of a Gα Mutant in Asymmetric Cell Division of Caenorhabditis elegans* (2008) (15)
- Commercial Cdk1 antibodies recognize the centrosomal protein Cep152. (2013) (13)
- Clathrin regulates centrosome positioning by promoting acto-myosin cortical tension in C. elegans embryos (2014) (13)
- Quantitative analysis and modeling probe polarity establishment in C. elegans embryos. (2015) (13)
- Multiciliogenesis: Multicilin Directs Transcriptional Activation of Centriole Formation (2014) (12)
- Integrated Microfluidic Device for Drug Studies of Early C. Elegans Embryogenesis (2018) (12)
- Novel features of centriole polarity and cartwheel stacking revealed by cryo‐tomography (2020) (12)
- SAS-1 Is a C2 Domain Protein Critical for Centriole Integrity in C. elegans (2014) (12)
- Physically asymmetric division of the C. elegans zygote ensures invariably successful embryogenesis (2020) (11)
- Computational support for a scaffolding mechanism of centriole assembly (2016) (11)
- Computer simulations reveal mechanisms that organize nuclear dynein forces to separate centrosomes (2017) (9)
- ASSET: A robust algorithm for the automated segmentation and standardization of early Caenorhabditis elegans embryos (2010) (9)
- Mutual Antagonism Between the Anaphase Promoting Complex and the Spindle Assembly Checkpoint Contributes to Mitotic Timing in Caenorhabditis elegans (2010) (9)
- Cellular hallmarks reveal restricted aerobic metabolism at thermal limits (2015) (9)
- Novel features of centriole polarity and cartwheel stacking revealed by cryo-tomography (2020) (8)
- Interaction between the Caenorhabditis elegans centriolar protein SAS-5 and microtubules facilitates organelle assembly (2018) (8)
- TRIM37 prevents formation of centriolar protein assemblies by regulating Centrobin (2021) (7)
- Kinetic and structural roles for the surface in guiding SAS-6 self-assembly to direct centriole architecture (2021) (7)
- Surface-catalyzed SAS-6 self-assembly directs centriole formation through kinetic and structural mechanisms (2020) (6)
- Isolation, cryotomography, and three-dimensional reconstruction of centrioles. (2015) (6)
- TRACMIT: An effective pipeline for tracking and analyzing cells on micropatterns through mitosis (2017) (5)
- Chemical Genetic Screen Identifies Natural Products that Modulate Centriole Number (2016) (5)
- Live imaging screen reveals that TYRO3 and GAK ensure accurate spindle positioning in human cells (2019) (5)
- Basal body structure in Trichonympha (2016) (5)
- Correction: PI(4,5)P2 forms dynamic cortical structures and directs actin distribution as well as polarity in Caenorhabditis elegans embryos (doi: 10.1242/dev.164988) (2018) (4)
- Aurora A depletion reveals centrosome-independent polarization mechanism in C.elegans (2018) (3)
- Tuning SAS-6 architecture with monobodies impairs distinct steps of centriole assembly (2021) (3)
- Structures of SAS-6 coiled coil hold implications for the polarity of the centriolar cartwheel (2022) (3)
- TRIM37 prevents formation of centriolar protein assemblies by regulating Centrobin stability (2020) (2)
- Pulchelloid A, a sesquiterpene lactone from the Canadian prairie plant Gaillardia aristata inhibits mitosis in human cells (2021) (2)
- Temperature gradient stimulation for cell division in C. Elegans Embryos on chip (2010) (2)
- Myosin Assembly The Power of Multiubiquitylation (2004) (2)
- ZYG-1 promotes limited centriole amplification in the C. elegans seam lineage. (2018) (2)
- An integrated microfluidic device for C. elegans early embryogenesis studies and drug assays (2017) (2)
- Polarity-Dependent Asymmetric Distribution and MEX-5/6–Mediated Translational Activation of the Era-1 mRNA in C. elegans Embryos (2015) (2)
- TRIM37: a critical orchestrator of centrosome function (2021) (1)
- Centriole foci persist in starfish oocytes despite Polo-like kinase 1 inactivation or loss of microtubule nucleation activity (2020) (1)
- Author response: Aurora A depletion reveals centrosome-independent polarization mechanism in Caenorhabditis elegans (2019) (1)
- PI(4,5)P2 forms dynamic cortical structures and directs actin distribution and cell polarity in C. elegans embryos (2017) (1)
- Atypical and distinct microtubule radial symmetries in the centriole and the axoneme of Lecudina tuzetae (2022) (1)
- Mutual antagonism between the Anaphase Promoting Complex and the Spindle Assembly Checkpoint contributes to mitotic timing in C . elegans (2010) (1)
- Molecular architecture of the C. elegans centriole (2022) (1)
- [Mechanisms of cell division: lessons from a nematode]. (2003) (1)
- Cortical Dynein Powered by Polarized Actomyosin Contractions and Pronuclear Dynein Separate Centrosomes (2015) (1)
- Centrosomes: Hooked on the Nucleus Dispatch (2004) (1)
- Table 1, Polarity establishment and maintenance proteins. (2005) (0)
- Native Architecture of the Centriole Proximal Region Reveals Features Underlying Its 9-Fold Radial Symmetry (2020) (0)
- Movie 5, Dual fluorescent and DIC microscopy of embryo carrying GFP::PIE-1 from the one-cell stage until the four-cell stage. (2005) (0)
- Sperm-contributed centrioles segregate stochastically into blastomeres of 4-cell stage Caenorhabditis elegans embryos (2023) (0)
- Movie 1, Time-lapse DIC microscopy of one-cell stage embryo from the onset of polarity establishment until the early two-cell stage. (2005) (0)
- Figure 3, Centrosome and spindle positioning in one-cell stage embryos. (2005) (0)
- MB_CRS6-15 bound to CrSAS-6_6HR (2021) (0)
- Live imaging screen reveals that TYRO3 and GAK ensure accurate spindle positioning in human cells (2019) (0)
- Table 3, Polarity mediators and cell fate regulators. (2005) (0)
- Tuning SAS-6 architecture with monobodies impairs distinct steps of centriole assembly (2021) (0)
- Inherited Immunodeficiency withaDefect inaMajor Histocompatibili ty Complex Class IIPromoter-Binding Protein Differs intheChromatin Structure oftheHLA-DRAGene (1989) (0)
- Table 2, Spindle positioning proteins and cell cycle regulators. (2005) (0)
- Clathrin regulates centrosome positioning by promoting acto-myosin cortical tension in C. elegans embryos (2014) (0)
- Supplementary Information : High-speed photothermal off-resonance 1 atomic force microscopy reveals assembly routes of centriolar scaffold 2 protein SAS-6 3 (2018) (0)
- Author response: The Caenorhabditis elegans protein SAS-5 forms large oligomeric assemblies critical for centriole formation (2015) (0)
- Multiview reconstruction with unknown poses for 3D fluorescence microscopy (2019) (0)
- Author response: TRIM37 prevents formation of centriolar protein assemblies by regulating Centrobin (2021) (0)
- DEV141515 2689..2689 (2016) (0)
- Figure 2, Anterior-posterior in one-cell stage embryos. (2005) (0)
- Figure 5, Asymmetric localization of polarity mediators and cell fate regulators in the early embryo. (2005) (0)
- Figure 4, Polarity and spindle positioning in two to six-cell stage embryos. (2005) (0)
- Grand canonical Brownian dynamics simulations of adsorption and self-assembly of SAS-6 rings on a surface (2022) (0)
- The capping function of CPAP limits centriolar microtubule growth in human cells (2016) (0)
- Microfluidic Devices: Integrated Microfluidic Device for Drug Studies of Early C. Elegans Embryogenesis (Adv. Sci. 5/2018) (2018) (0)
- Uncovering the balance of forces driving microtubule aster migration in C. elegans zygotes (2018) (0)
- Cytoplasmic Volume Modulates Spindle Size During Embryogenesis (2013) (0)
- Figure 1, Generation of founder cells in the early embryo. (2005) (0)
- Homogeneous multifocal excitation for high-throughput super-resolution imaging (2020) (0)
- Cortical localization of the G (cid:2)(cid:2) protein GPA-16 requires RIC-8 function during C. elegans asymmetric cell division (2005) (0)
- The life cycle of the centrosome field (2014) (0)
- COMMENTARY Mechanisms of nuclear positioning (1998) (0)
- Movie 4, Spinning disc fluorescent microscopy of mitotic one-cell stage embryo carrying EB2::GFP. (2005) (0)
- Corrigendum: SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture (2016) (0)
- Tubulin engineering by semisynthesis reveals that polyglutamylation directs detyrosination (2022) (0)
- Movie 3, Simulation of a mathematical model of polarity establishment. (2005) (0)
- NuMA links the mitotic spindle with plasma membrane lipids (2014) (0)
- Solution structure of End Binding proteins ( EB ) determined by Small Angle X-ray Scattering (2010) (0)
- Movie 2, Dual fluorescent and DIC microscopy of one-cell stage embryo carrying mCherry::PAR-6 and GFP::PAR-2 from the onset of polarity establishment until the early two-cell stage. (2005) (0)
- Author response: Cellular hallmarks reveal restricted aerobic metabolism at thermal limits (2014) (0)
- The Human Centriolar Pro tein CEP 135 Contains a Two-Stranded Coiled-Coil Domain Critical for Microtubule Binding Highlights (0)
- Multicolor single-particle reconstruction of protein complexes (2018) (0)
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