Pierre De Meyts

Q: What Schools Are Affiliated With Pierre De Meyts

Pierre De Meyts is affiliated with the following schools: University of Liège, University of Southern California, University of Copenhagen

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Pierre De Meyts

Biology

#6299

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#8983

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Molecular Biology

#1399

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#1426

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Biochemistry

#1577

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#1708

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Neuroscience

#1694

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#1747

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Biology

Why Is Pierre De Meyts Influential?

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According to Wikipedia, Pierre De Meyts is a Belgian physician and biochemist known for his research on fine chemical and kinetic aspects of ligand-receptor interaction, subunit assembly, and specific metabolic effects of hormones typically causing receptor tyrosine kinase activation such as insulin and insulin-like growth factors . He has also studied receptor signalling for other peptide hormones such as growth hormone and relaxin, and key pathophysiological aspects of diabetes mellitus. De Meyts held professorial posts for over three decades at several European and United States institutions and currently is an emeritus professor in the Science Faculty at the Université catholique de Louvain. While living in Denmark he occupied executive research positions at Novo Nordisk. De Meyts is also known as a science cartoonist.

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Pierre De Meyts's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Insulin-dependent regulation of insulin receptor concentrations: a direct demonstration in cell culture. (1974) (944)
Insulin interactions with its receptors: experimental evidence for negative cooperativity. (1973) (628)
Structural biology of insulin and IGF1 receptors: implications for drug design (2002) (539)
Fluctuations in the affinity and concentration of insulin receptors on circulating monocytes of obese patients: effects of starvation, refeeding, and dieting. (1976) (391)
The Insulin-Like Growth Factor-I Receptor (1994) (382)
Cooperativity in ligand binding: a new graphic analysis. (1975) (377)
Alterations in insulin binding induced by changes in vivo in the levels of glucocorticoids and growth hormone. (1978) (253)
Mapping of the residues responsible for the negative cooperativity of the receptor-binding region of insulin (1978) (189)
Mitogenic properties of insulin and insulin analogues mediated by the insulin receptor (1997) (188)
Insulin and its receptor: structure, function and evolution. (2004) (187)
Insulin and its receptor: structure, function and evolution (2004) (184)
A highly sensitive and specific assay for determination of IGF-I bioactivity in human serum. (2003) (175)
β-Adrenergic receptors: Evidence for negative cooperativity (1975) (170)
Receptors for insulin, NSILA-s, and growth hormone: applications to disease states in man. (1975) (168)
The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling (1994) (166)
The insulin receptor in vertebrates is functionally more conserved during evolution than insulin itself. (1979) (155)
Harmonic oscillator model of the insulin and IGF1 receptors' allosteric binding and activation (2009) (143)
Cooperative properties of hormone receptors in cell membranes. (1976) (129)
Role of histone and transcription factor acetylation in diabetes pathogenesis (2005) (127)
The Insulin Receptor and Its Signal Transduction Network (2016) (124)
Receptor dimerization determines the effects of growth hormone in primary rat adipocytes and cultured human IM-9 lymphocytes. (1994) (110)
The insulin receptor: a prototype for dimeric, allosteric membrane receptors? (2008) (106)
Gene Expression in Skeletal Muscle Biopsies from People with Type 2 Diabetes and Relatives: Differential Regulation of Insulin Signaling Pathways (2009) (102)
How ligand binds to the type 1 insulin-like growth factor receptor (2018) (79)
Pancreatic hormone receptors on islet cells. (1985) (78)
Negative cooperativity in the insulin-like growth factor-I receptor and a chimeric IGF-I/insulin receptor. (1994) (75)
Molecular mechanisms of differential intracellular signaling from the insulin receptor. (2009) (74)
Identification of determinants that confer ligand specificity on the insulin receptor. (1992) (73)
The insulin-like growth factor-I receptor. Structure, ligand-binding mechanism and signal transduction. (1994) (72)
Beta-adrenergic receptors: evidence for negative cooperativity. (1975) (71)
Activation of the Insulin Receptor by Insulin and a Synthetic Peptide Leads to Divergent Metabolic and Mitogenic Signaling and Responses* (2007) (70)
The insulin receptor: a prototype for dimeric, allosteric membrane receptors? (2008) (69)
Mitogenic and Antiadipogenic Properties of Human Growth Hormone in Differentiating Human Adipocyte Precursor Cells in Primary Culture1 (1996) (68)
How Insulin Binds: the B-Chain α-Helix Contacts the L1 β-Helix of the Insulin Receptor (2004) (67)
Insulin-induced dissociation of its receptor into subunits: possible molecular concomitant of negative cooperativity. (1976) (66)
Biosensor Measurement of the Binding of Insulin-like Growth Factors I and II and Their Analogues to the Insulin-like Growth Factor-binding Protein-3* (1996) (66)
Identification of a ligand-binding region of the human insulin receptor encoded by the second exon of the gene. (1990) (64)
Genetic engineering in mice: impact on insulin signalling and action. (1998) (60)
Biological effects of human growth hormone in rat adipocyte precursor cells and newly differentiated adipocytes in primary culture. (1996) (58)
Alanine Scanning of a Putative Receptor Binding Surface of Insulin-like Growth Factor-I* (2008) (57)
Thermodynamics of the interaction of insulin with its receptor. (1979) (57)
Role of the time factor in signaling specificity: application to mitogenic and metabolic signaling by the insulin and insulin-like growth factor-I receptor tyrosine kinases. (1995) (57)
Insulin/receptor binding: The last piece of the puzzle? (2015) (57)
Mechanism of Insulin and IGF‐I (1995) (57)
Short stature associated with a novel heterozygous mutation in the insulin-like growth factor 1 gene. (2010) (56)
The Insulin Receptor and Insulin of the Atlantic Hagfish: Extraordinary Conservation of Binding Specificity and Negative Cooperativity in the Most Primitive Vertebrate (1979) (55)
Structural biology of insulin and IGF-1 receptors. (2004) (54)
Drosophila Insulin-Like Peptides DILP2 and DILP5 Differentially Stimulate Cell Signaling and Glycogen Phosphorylase to Regulate Longevity (2018) (54)
Cell surface receptors for insulin and human growth hormone. Effect of microtubule and microfilament modifiers. (1976) (54)
Structural and Biological Properties of the Drosophila Insulin-like Peptide 5 Show Evolutionary Conservation* (2010) (53)
Sphingosine, an inhibitor of protein kinase C, suppresses the insulin-like effects of growth hormone in rat adipocytes. (1989) (52)
Binding and degradation of insulin by human peripheral granulocytes. Demonstration of specific receptors with high affinity. (1976) (50)
Viral insulin-like peptides activate human insulin and IGF-1 receptor signaling: A paradigm shift for host–microbe interactions (2018) (50)
An arginine to cysteine252 mutation in insulin receptors from a patient with severe insulin resistance inhibits receptor internalisation but preserves signalling events (2002) (49)
Carbohydrate metabolism in women who used oral contraceptives containing levonorgestrel or desogestrel: a 6-month prospective study. (1986) (49)
Insulin/receptor binding: the last piece of the puzzle? What recent progress on the structure of the insulin/receptor complex tells us (or not) about negative cooperativity and activation. (2015) (48)
Pancreatic α-cell hyperplasia and hyperglucagonemia due to a glucagon receptor splice mutation (2016) (45)
Logical analysis of timing-dependent receptor signalling specificity: application to the insulin receptor metabolic and mitogenic signalling pathways. (1997) (45)
p38 MAPK activation upregulates proinflammatory pathways in skeletal muscle cells from insulin-resistant type 2 diabetic patients. (2015) (45)
Agonism and Antagonism at the Insulin Receptor (2012) (45)
Cooperative binding of insulin-like Peptide 3 to a dimeric relaxin family peptide receptor 2. (2008) (44)
SysBioMed report: advancing systems biology for medical applications. (2009) (43)
Role of kinase C in the insulin-like effects of human growth hormone in rat adipocytes. (1987) (42)
The A-chain of Insulin Contacts the Insert Domain of the Insulin Receptor (2007) (42)
Separation of Fast from Slow Anabolism by Site-specific PEGylation of Insulin-like Growth Factor I (IGF-I)* (2011) (41)
Negative cooperativity in H2 relaxin binding to a dimeric relaxin family peptide receptor 1 (2008) (39)
Structural Basis for the Lower Affinity of the Insulin-like Growth Factors for the Insulin Receptor* (2008) (37)
Receptor binding properties and insulin-like effects of human growth hormone and its 20 kDa-variant in rat adipocytes. (1987) (37)
Receptor Oligomerization in Family B1 of G-Protein-Coupled Receptors: Focus on BRET Investigations and the Link between GPCR Oligomerization and Binding Cooperativity (2012) (37)
Insulin and insulin-like growth factor-I receptor mediated differentiation of 3T3-F442A cells into adipocytes: effect of PI 3-kinase inhibition. (1998) (36)
Identification and characterization of insulin receptors on foetal-mouse brain-cortical cells. (1984) (36)
Receptor-binding and down-regulatory properties of 22000-Mr human growth hormone and its natural 20000-Mr variant on IM-9 human lymphocytes. (1985) (35)
Activation of the insulin receptor (IR) by insulin and a synthetic peptide has different effects on gene expression in IR-transfected L6 myoblasts. (2008) (34)
Mechanism of insulin and IGF-I receptor activation and signal transduction specificity. Receptor dimer cross-linking, bell-shaped curves, and sustained versus transient signaling. (1995) (34)
The insulin-like growth factors and insulin-signalling systems: an appealing target for breast cancer therapy? (2003) (34)
Timing-dependence of insulin-receptor mitogenic versus metabolic signalling: a plausible model based on coincidence of hormone and effector binding. (1999) (34)
Insulin receptor‐deficient cells as a new tool for dissecting complex interplay in insulin and insulin‐like growth factors (1998) (33)
Engineering the C-region of human insulin-like growth factor-1: implications for receptor binding. (1996) (33)
The receptor binding properties of the 20K variant of human growth hormone explain its discrepant insulin-like and growth promoting activities. (1986) (32)
Structural Basis of Allosteric Ligand–Receptor Interactions in the Insulin/Relaxin Peptide Family (2009) (32)
The growth hormone (GH)-binding protein cloned from human IM-9 lymphocytes modulates the down-regulation of GH receptors by 22- and 20-kilodalton human GH in IM-9 lymphocytes and the biological effects of the hormone in Nb2 lymphoma cells. (1993) (31)
A Novel Binding Site for the Human Insulin-like Growth Factor-II (IGF-II)/Mannose 6-Phosphate Receptor on IGF-II* (2007) (31)
Glycosylation of cell surface receptors: tunicamycin treatment decreases insulin and growth hormone binding to different levels in cultured lymphocytes. (1981) (31)
Crystal Structure of a “Nonfoldable” Insulin (2009) (30)
IGF-I, IGF-II, and Insulin Stimulate Different Gene Expression Responses through Binding to the IGF-I Receptor (2013) (30)
Impaired negative cooperativity of the semisynthetic analogues human [LeuB24]- and [LeuB25]-insulins. (1981) (30)
Cooperative properties of hormone receptors in cell membranes. (1976) (30)
Human insulin prepared by recombinant DNA techniques and native human insulin interact identically with insulin receptors. (1981) (30)
Structural basis for the lower affinity of the insulin-like growth factors for the insulin receptor. (2006) (28)
Inhibition by insulin of glucocorticoid-induced gene transcription: involvement of the ligand-binding domain of the glucocorticoid receptor and independence from the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways. (1998) (28)
Insight into the molecular basis for the kinetic differences between the two insulin receptor isoforms. (2011) (28)
Modelling of the disulphide-swapped isomer of human insulin-like growth factor-1: implications for receptor binding. (1999) (27)
Insulin and IGF-I Receptor Structure and Binding Mechanism (2007) (25)
Reversal of insulin-induced negative cooperativity by monoclonal antibodies that stabilize the slowly dissociating ("Ksuper") state of the insulin receptor. (1988) (24)
Intracellular potassium depletion in IM-9 lymphocytes suppresses the slowly dissociating component of human growth hormone binding and the down-regulation of its receptors but does not affect insulin receptors. (1986) (22)
Acridine orange, an inhibitor of protein kinase C, abolishes insulin and growth hormone stimulation of lipogenesis in rat adipocytes (1989) (22)
Insulin-like growth factor I (IGF-I) is a more potent regulator of gene expression than insulin in primary human myoblasts and myotubes. (2009) (22)
The same region of human growth hormone is involved in its binding to various receptors. (1982) (22)
Dimerization and Negative Cooperativity in the Relaxin Family Peptide Receptors (2009) (20)
Cellular processing of growth hormone in IM-9 cells: evidence for exocytosis of internalized hormone. (1992) (19)
Mutation of arginine 86 to proline in the insulin receptor alpha subunit causes lack of transport of the receptor to the plasma membrane, loss of binding affinity and a constitutively activated tyrosine kinase in transfected cells. (1993) (18)
Insulin receptor substrates-5 and -6 are poor substrates for the insulin receptor. (2009) (18)
In Vitro Studies on Biosynthetic Human Insulin: an Overview (1981) (18)
Alternative Splicing of Exon 17 and a Missense Mutation in Exon 20 of the Insulin Receptor Gene in Two Brothers with a Novel Syndrome of Insulin Resistance (Congenital Fiber-Type Disproportion Myopathy) (1999) (17)
Insulin & Related Proteins - Structure to Function and Pharmacology (2002) (17)
Regulation of receptor by homologous hormone enhances sensitivity and broadens scope of radioreceptor assay for human growth hormone. (1979) (16)
Negative and positive site-site interactions, and their modulation by pH, insulin analogs, and monoclonal antibodies, are preserved in the purified insulin receptor. (1988) (16)
Down-regulation of cyclin G2 by insulin, IGF-I (insulin-like growth factor 1) and X10 (AspB10 insulin): role in mitogenesis. (2014) (16)
How insulin binds: the B-chain alpha-helix contacts the L1 beta-helix of the insulin receptor. (2004) (16)
Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones (2018) (15)
Growth failure in a child showing characteristics of Seckel syndrome: possible effects of IGF‐I and endogenous IGFBP‐3 (2002) (15)
Insulin receptors and insulin action (1996) (13)
The diabetogenes concept of NIDDM. (1993) (13)
Comparison of the effects of hypertonic sucrose and intracellular potassium depletion on growth hormone receptor binding kinetics and down-regulation in IM-9 cells: evidence for a sequential block of receptor--mediated endocytosis. (1991) (13)
Structural Basis of the Aberrant Receptor Binding Properties of Hagfish and Lamprey Insulins† (2009) (13)
Preparation and expression of biologically active prolactin and growth hormone receptors and suppressor of cytokine signaling proteins 1, 2, 3, and 6 tagged with cyan and yellow fluorescent proteins. (2002) (13)
Mitogenic Potential of Insulin on Lymphoma Cells Lacking IGF‐1 Receptor a (1995) (13)
Human growth hormone increases cytosolic free calcium in cultured human IM-9 lymphocytes: a novel mechanism of growth hormone transmembrane signalling. (1994) (12)
Inhibition of insulin receptor binding by dimethyl sulfoxide. (1979) (12)
DOK4/IRS‐5 expression is altered in clear cell renal cell carcinoma (2007) (11)
Total Solid-Phase Synthesis of Biologically Active Drosophila Insulin-Like Peptide 2 (DILP2). (2017) (11)
The diabetogenes concept of NIDDM. (1993) (11)
Receptor concepts. A century of evolution. (1980) (10)
Receptor Binding Properties and Biologic Activity In Vitro of Biosynthetic Human Insulin (1981) (10)
Serum growth hormone levels measured by radioimmunoassay and radioreceptor assay: a useful diagnostic tool in children with growth disorders? (1990) (9)
The severe short stature in two siblings with a heterozygous IGF1 mutation is not caused by a dominant negative effect of the putative truncated protein. (2011) (9)
EFFECTS OF STARVATION, REFEEDING, AND DIETING (1976) (9)
The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling. (1994) (8)
ISPAD 2001: 1st Announcement (1999) (8)
The Hypoglycemic Effect of a Sulfonylurea (gliclazide) in Moderate Type-ii Diabetes and Glucose-intolerance Is Not Accompanied By Changes in Insulin Action and Insulin Binding To Erythrocytes (1983) (8)
Insulin and insulin-like growth factors: the paradox of signaling specificity. (2002) (8)
Insulin and insulin-like growth factors: the paradox of signaling specificity. (2002) (8)
Immunological and Metabolic Responses of Patients with History of Antibody-Induced Beef Insulin Resistance to Treatment With Beef, Pork, Human, and Sulfated Beef Insulin (1992) (8)
Structure-Activity Relationships of Insulin-Induced Negative Cooperativity Among Receptor Sites (1980) (8)
Insulin: a hundred year-old discovery with a fascinating history. (2021) (8)
IRS-4 mediated mitogenic signalling by insulin and growth hormone in LB cells, a murine T-cell lymphoma devoid of IGF-I receptors. (2003) (7)
Measuring growth hormone activity through receptor and binding protein assays. (1991) (7)
Structure of growth hormone and its receptor: an unexpected stoichiometry. (1992) (6)
The insulin receptor isoform A: a mitogenic proinsulin receptor? (2012) (6)
The insulin receptor isoform A: a mitogenic proinsulin receptor? (2012) (5)
Structure-function studies of an IGF-I analogue that can be chemically cleaved to a two-chain mini-IGF-I. (2001) (5)
Preparation and biological properties of [LeuB24, LeuB25]human insulin. (1981) (5)
Editorial: The Brain – Gut – Microbiome Network in Metabolic Regulation and Dysregulation (2021) (5)
Timing-dependent modulation of insulin mitogenic versus metabolic signalling. (2000) (5)
Structure-function relationships of shortened [LeuB25]insulins, semisynthetic analogues of a mutant human insulin. (1986) (5)
Monoclonal Antibodies Against Growth Hormone: Effects on the Hormone Interaction with Specific Cell Surface Receptors (1982) (4)
Binding kinetics of mutated insulin receptors in transfected cells grown in suspension culture: application to the Tyr----Phe 960 insulin receptor mutant. (1989) (4)
Structure-Function Relationships of Insulin and Insulin-Like Growth factor-I Receptor Binding (2002) (4)
Early Recombinant Protein Therapeutics (2017) (3)
Structural basis for the poisonous activity of a predator's venom insulin (2016) (3)
Receptor Activation by Antigens, Cytokines, Hormones and Growth Factors (1995) (3)
Pancreatic Hormones (2020) (3)
[Insulin receptors and mechanism of action of insulin and of insulin-like growth factors]. (1994) (2)
The International Consortium on Systems Biology of Receptor Tyrosine Kinase Regulatory Networks. (2005) (2)
A rapid method for the preparation of 125I-labelled human growth hormone for receptor studies, using reverse-phase high performance liquid chromatography. (1986) (2)
Receptor Tyrosine Kinase Signal Transduction and the Molecular Basis of Signalling Specificity (2015) (2)
Gene Expression Profiling of Human Adipocyte Responses to Insulin and IGF-I Signalling (2009) (2)
Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones (2018) (1)
Structure of growth hormone and its receptor: an unexpected stoichiometry. (1992) (1)
An improved radioreceptor assay for human growth hormone using an HPLC-purified 125I-hGH (1984) (1)
In Memoriam: Guy Dodson (1937–2012) (2013) (1)
How ligand binds to the type 1 insulin-like growth factor receptor (2018) (1)
[Vasomotor action of D(-)-ephedprine and L(+) psi-ephedrine in rats]. (1968) (1)
Structural basis for the poisonous activity of a predator's venom insulin (2016) (1)
Carbohydrate-metabolism in Normal Women Using Oral-contraceptives Containing Levonorgestrel Or Desogestrel - a 6 Month Prospective-study (1984) (1)
In Memoriam: Guy Dodson (1937–2012) (2013) (1)
GH and ACTH secretion in insulin-induced hypoglycemia in normal children. (1974) (1)
Effect of Gliclazide On Insulin Effectiveness and Insulin Binding To Erythrocytes in Type-2 (non-insulin-dependent) Diabetic-patients (1982) (1)
[D(-)ephedrine and L(+)psi-ephedrine as sympathomimetic amines with indirect action in the rat]. (1967) (1)
[Ephedrine as a sympathicomimetic amine with indirect action in the rat]. (1966) (1)
The Structure and Function of Insulin Receptor (1991) (1)
[Dynamic explorations of ACTH secretion]. (1970) (0)
Negative Cooperativity Induced During the Slow Phase of I-125-insulin Dissociation Is Identical To That Induced At Time Zero of Dissociation (1982) (0)
THE STRUCTURAL BASIS OF INSULIN-RECEPTOR BINDING AND COOPERATIVE INTERACTIONS (1978) (0)
Biology of IGF-I: Its interaction with insulin in health and malignant States Novartis Foundation Symposium No. 263 London, 13-16 October 2003 (2003) (0)
Crystal structure of DILP5 variant C4 (2010) (0)
The Mechanism of Insulin Receptor Binding, Activation and Signal Transduction (1997) (0)
A Scientist and a Cartoonist: how Chuck came to be (2005) (0)
[22K and 20K growth hormone: correlation of receptor binding and the biological effect on rat adipocytes]. (1987) (0)
P-20: Receptor binding of IGF-1 requires a conformational change (2009) (0)
[The insuline receptor: structure and function]. (2005) (0)
Hepatotoxicity induced by diethylnitrosamine causes no significant disturbances of systemic glucose homeostasis in rats. (1990) (0)
Cooperative Regulation of Hormone Binding Affinity for Cell Surface Receptors (1976) (0)
P78 Elimination of acute drug side effects without loss of efficacy by site-specific PEGylation of insulin-like growth factor I (2010) (0)
[Pseudo-ephedrine as sympathomimetic amine with indirect action in the rat]. (1967) (0)
Receptor binding of insulin-like growth factor 1 requires a conformational change (1996) (0)
[The insulin receptor discovery is 50 years old - A review of achieved progress]. (2022) (0)
O-42: Mitogenic signalling by insulin in a T-cell lymphoma, the LB cell line, devoid of IGF-I receptors: evidence for the lack of involvement of the RAS-MAP kinase pathway and for a possibly novel IRS-like molecule (2009) (0)
Editorial: Special 2021 Frontiers in Endocrinology collection for the 100th anniversary of insulin discovery (2023) (0)
P-16: Kinetics and cooperative properties of insulin, IGF-I and a single chain insulin/IGF-I hybrid ligand (ICP) binding to a chimeric insulin/IGF-I receptor (2009) (0)
[Action of calcium ions on adrenalin-induced arterial hypertension in rats]. (1966) (0)
[Action of magnesium and calcium ions on the isolated intestine of the rat]. (1965) (0)
Crystal structure of Drosophila imaginal morphogenesis protein-Late 2 (IMP-L2) in free form and bound to Drosophila insulin-like peptide 5 (DILP5) and human Insulin-like growth factor-I (hIGF1). (2014) (0)
Hla Antigens and Cell-surface Receptors - a Potent Monoclonal-antibody Against the Hla-dr of the Human Im-9-lymphoblastoid Cell-line Affects Insulin Binding To its Receptor On These Cells (2004) (0)
OR6,2 Short stature caused by a novel heterozygous mutation in the IGF-I gene (2008) (0)
P-6: Presence of inactive insulin-like growth factor-I receptors on primary rat adipocytes (2009) (0)
Kinetics of IGF-1 analogues binding to the IGF binding protein-3 measured using a biosensor (1994) (0)
[Clinical usefulness of the determination of erythrocyte insulin receptors]. (1982) (0)
Role of Receptor Glycosylation in the Expression of Insulin Receptor-binding Capacity (1980) (0)
Biology of IGF-I (2003) (0)
Editorial: Recent advances in molecular and structural endocrinology (2023) (0)
[The insulin receptor and the concept of negative cooperativity]. (1980) (0)
Lack of High-affinity Insulin-receptors On Purified Pancreatic-a Cells (1984) (0)
P-56: Signaling pathway leading to the insulin-induced inhibition of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene transcription (2009) (0)
[Image of the month. The human insulin hexamer]. (2005) (0)
P-13: The importance of the exon six encoded domain of the IR and IGF-I-R in ligand binding (2009) (0)
Fetal Murine Brain-cells Express Insulin-receptors Which Differ From Most Classical Insulin-receptors (2004) (0)
Intracellular signaling discriminates between high- and low-mitogenic insulin analogues in human mammary adenocarcinoma cells (2010) (0)
Crystal structure of Drosophila neural ectodermal development factor Imp-L2 with Drosophila DILP5 insulin (2018) (0)
Structure and function of human insulin-like growth factor (2002) (0)
Structural Conservation of Insulin/IGF Signalling Axis at the Insulin Receptors Level in Drosophila and Humans (2023) (0)
A splice site mutation in the human glucagon receptor gene abolishes function and causes pancreaticβ-cell hyperplasia and hyperglucagonemia (2000) (0)
HUMAN GROWTH HORMONE INCREASES THE INTRACELLULAR FREE CALCIUM IN CULTURED HUMAN IM-9 LYMPHOCYTES (1993) (0)
Crystal structure of neural ectodermal development factor IMP-L2. (2014) (0)
NMR STRUCTURE OF HUMAN INSULIN MUTANT HIS-B10-ASP, VAL-B12-THR, PRO-B28-LYS, LYS-B29-PRO, 15 STRUCTURES (2004) (0)
60 Insulin receptor substrate 5 (IRS-5). Its regulation and altered expression in cancer (2007) (0)
P-7: Kinetic and equilibrium properties of a cross-linking model of insulin receptor binding (2009) (0)
A Scientist and a Cartoonist: how Chuck came to be (2005) (0)
Negative and positive site-site interactions , and their modulation by pH , insulin analogs , and monoclonal antibodies , are preserved in the purified insulin receptor ( receptor-affinity changes / negative cooperativity / insulin struct ction relationships ) (0)
P-5: Insulin dose-response curves and IGF-I cross-reactivity in cells expressing only one receptor type: evidence for different requirements for monovalent versus bivalent insulin binding of metabolic and mitogenic signaling (2009) (0)
NMR STRUCTURE OF HUMAN INSULIN MUTANT HIS-B10-ASP, VAL-B12-ABA, PRO-B28-LYS, LYS-B29-PRO, 15 STRUCTURES (2004) (0)
P-9: Analysis of determination of signalling specificity in the insulin receptor through coincidence of hormone and effector binding (2009) (0)
An Improved Method for Measuring the Affinity and Concentration of Insulin-receptors Using Native Insulin and a Noncooperative Analog (1980) (0)
Crystal structure of Drosophila neural ectodermal development factor Imp-L1 with Human IGF-I (2018) (0)
Potency of Insulin Analogues on Lipogenesis is Determined Early in the Binding Process (1998) (0)
In memoriam: Jacques E. Dumont (1931-2023) (2023) (0)
Logical analysis of the effect of timing of receptor binding on signalling specificity (2009) (0)

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