Piers Nash
British biochemist
Piers Nash's AcademicInfluence.com Rankings
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Biology
Piers Nash's Degrees
- PhD Biochemistry University of Oxford
Why Is Piers Nash Influential?
(Suggest an Edit or Addition)According to Wikipedia, Piers David Nash is an entrepreneur, cancer biology professor, data evangelist, writer and technology futurist. He is the son of academic Roger Nash. Early life and education Born in Exeter, England, and grew up in Sudbury, Ontario, Canada. In high school he competed in the Canada-Wide Science Fair in five successive years , winning awards on each occasion and becoming one of the most highly awarded science fair participants in the history of the fair. In recognition of this he was selected to represent Canada as one of two youth delegates to the 1985 Nobel Prize lectures and ceremony in Stockholm, Sweden as part of the Stockholm International Youth Science Seminar and was awarded the International Youth Year Ontario Gold Medal. He received a BSc with honours in biochemistry from the University of Guelph, and the Chemical Institute of Canada prize for the top of class and President's Scholarship. He received a PhD in 1999 from the University of Alberta working in the laboratory of Dr. Grant McFadden investigating poxviral immunomodulatory proteins. His doctoral thesis focused on the enzymology and biological properties of the Myxoma virus encoded serine proteinase inhibitor , SERP-1. He completed postdoctoral research with Anthony Pawson at the Samuel Lunenfeld Research Institute of Mount Sinai Hospital and the University of Toronto from June 1999 to December 2003. In 2014, Nash received an MBA with a concentration in finance awarded with high honors from the University of Chicago Booth School of Business. From 2014 to 2017, Nash was Director in the for Data-Intensive Science that was building and managing the National Cancer Institute Genomic Data Commons with Robert Lee Grossman.
Piers Nash's Published Works
Published Works
- Assembly of Cell Regulatory Systems Through Protein Interaction Domains (2003) (1403)
- Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication (2001) (812)
- Protein-protein interactions define specificity in signal transduction. (2000) (714)
- SH2 domains, interaction modules and cellular wiring. (2001) (395)
- The human and mouse complement of SH2 domain proteins-establishing the boundaries of phosphotyrosine signaling. (2006) (291)
- Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling (2013) (252)
- The Murine Nck SH2/SH3 Adaptors Are Important for the Development of Mesoderm-Derived Embryonic Structures and for Regulating the Cellular Actin Network (2003) (187)
- High-throughput phosphotyrosine profiling using SH2 domains. (2007) (171)
- Interaction domains: from simple binding events to complex cellular behavior (2002) (156)
- Structural basis for specific binding of the Gads SH3 domain to an RxxK motif-containing SLP-76 peptide: a novel mode of peptide recognition. (2003) (137)
- A High-Affinity Arg-X-X-Lys SH3 Binding Motif Confers Specificity for the Interaction between Gads and SLP-76 in T Cell Signaling (2002) (135)
- Immunomodulation by viruses: the myxoma virus story (1999) (128)
- SH2 Domains Recognize Contextual Peptide Sequence Information to Determine Selectivity* (2010) (119)
- Virus-encoded serine proteinase inhibitor SERP-1 inhibits atherosclerotic plaque development after balloon angioplasty. (1996) (104)
- Interruption of cytokine networks by poxviruses: lessons from myxoma virus (1995) (99)
- The language of SH2 domain interactions defines phosphotyrosine‐mediated signal transduction (2012) (98)
- Regulation of Endocytic Sorting by ESCRT–DUB-Mediated Deubiquitination (2011) (92)
- Regulation of Epidermal Growth Factor Receptor Ubiquitination and Trafficking by the USP8·STAM Complex* (2010) (90)
- The SH2 Domain–Containing Proteins in 21 Species Establish the Provenance and Scope of Phosphotyrosine Signaling in Eukaryotes (2011) (88)
- Inhibitory Specificity of the Anti-inflammatory Myxoma Virus Serpin, SERP-1* (1998) (84)
- Manipulation of EphB2 Regulatory Motifs and SH2 Binding Sites Switches MAPK Signaling and Biological Activity* (2003) (79)
- The Deubiquitinating Enzyme USP8 Promotes Trafficking and Degradation of the Chemokine Receptor 4 at the Sorting Endosome* (2010) (79)
- Virus-encoded receptors for cytokines and chemokines. (1998) (78)
- Calreticulin: not just another calcium-binding protein (1994) (71)
- Evolution of SH2 domains and phosphotyrosine signalling networks (2012) (71)
- AMSH Interacts with ESCRT-0 to Regulate the Stability and Trafficking of CXCR4* (2010) (66)
- Inhibition of transplant vasculopathy in a rat aortic allograft model after infusion of anti-inflammatory viral serpin. (2000) (55)
- Ubiquitinylation of Igβ Dictates the Endocytic Fate of the B Cell Antigen Receptor1 (2007) (53)
- High‐throughput analysis of peptide‐binding modules (2012) (46)
- SRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactome (2012) (43)
- Recruitment of histone deacetylase 4 to the N-terminal region of estrogen receptor alpha. (2005) (42)
- Identification of Myxomaviral Serpin Reactive Site Loop Sequences That Regulate Innate Immune Responses* (2006) (36)
- Amelioration of antigen induced arthritis in rabbits treated with a secreted viral serine proteinase inhibitor. (1996) (36)
- Ubiquitinylation of Ig beta dictates the endocytic fate of the B cell antigen receptor. (2007) (34)
- Transplant vasculopathy: viral anti-inflammatory serpin regulation of atherogenesis. (2000) (28)
- SERP-1, a poxvirus-encoded serpin, is expressed as a secreted glycoprotein that inhibits the inflammatory response to myxoma virus infection. (1997) (26)
- Optical Detection of Triggered Atherosclerotic Plaque Disruption by Fluorescence Emission Analysis¶ (2000) (24)
- Myxoma Virus Expresses a TNF Receptor Homolog with two Distinct Functions (2004) (23)
- Post-translational modification of the myxoma-virus anti-inflammatory serpin SERP-1 by a virally encoded sialyltransferase. (2000) (20)
- Why modules matter (2012) (16)
- Optical Detection of Triggered Atherosclerotic Plaque Disruption by Fluorescence Emission Analysis ¶ (2000) (11)
- The Development and Application of a Quantitative Peptide Microarray Based Approach to Protein Interaction Domain Specificity Space* (2014) (11)
- Regions outside of conserved PxxPxR motifs drive the high affinity interaction of GRB2 with SH3 domain ligands. (2015) (11)
- The interaction of IgG with Fc gamma RII: involvement of the lower hinge binding site as probed by NMR. (1993) (7)
- Application of linear free energy relationships to the serpin–proteinase inhibition mechanism (2000) (6)
- Detection of transplant vasculopathy in a rat aortic allograft model by fluorescence spectroscopic optical analysis (1999) (5)
- Modular Protein Interaction Domains in Cellular Communication (2010) (5)
- Glycosylation of antibody molecules. A small step for structure, a leap for function. (1995) (4)
- Designing and deploying a bioinformatics software-defined network exchange (SDX): Architecture, services, capabilities, and foundation technologies (2017) (4)
- The SH2 Domain: A Prototype for Protein Interaction Modules (2008) (4)
- Glycosylation of Antibody Molecules (1995) (4)
- CHAPTER 67 – Modular Protein Interaction Domains in Cellular Communication (2003) (1)
- Supplemental Data High-Throughput Phosphotyrosine Profiling Using SH 2 Domains (2007) (1)
- Fate of the B Cell Antigen Receptor Dictates the Endocytic β Ubiquitinylation of Ig (2007) (1)
- OPTIMIZATION OF A MULTI-ENZYME ONE POT SYNTHESIS BY 1H-NMR (2002) (0)
- Evolution and interaction complexity in phosphotyrosine signaling may contribute to cellular heterogeneity (2016) (0)
- Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling (2013) (0)
- THE HUMAN COMPLEMENT OF SH 2 DOMAIN PROTEINS (2005) (0)
- What Gifted Secondary School Students Tell about Their School Programs (1989) (0)
- The Development and Application of a Quantitative Peptide Microarray Based Approach to Protein Interaction Domain (2014) (0)
- The Development and Application of a Quantitative Peptide Microarray Based Approach to Protein Interaction Domain Specificity Space*□S (2014) (0)
- Structural Basis for Specific Recognition of an RxxK-containing SLP-76 peptide by the Gads C-terminal SH3 domain (2003) (0)
- SRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactome (2012) (0)
- Laser-induced fluorescence spectroscopy (LFS): detection of unstable thrombogenic atherosclerotic plaque formation in a rabbit model: a first-look diagnostic approach (2000) (0)
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