Qiang Shen
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Qiang Shencomputer-science Degrees
Computer Science
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Artificial Intelligence
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Computer Science
Why Is Qiang Shen Influential?
(Suggest an Edit or Addition)Qiang Shen's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Molecular mechanisms of endothelial hyperpermeability: implications in inflammation (2009) (339)
- Tau protein aggregation is associated with cellular senescence in the brain (2018) (283)
- Transcription Factor STAT3 as a Novel Molecular Target for Cancer Prevention (2014) (239)
- Cancer drug delivery in the nano era: An overview and perspectives (2017) (235)
- Myosin light chain kinase in microvascular endothelial barrier function. (2010) (208)
- The role of STAT3 in leading the crosstalk between human cancers and the immune system. (2018) (200)
- Metformin attenuates cardiac fibrosis by inhibiting the TGFbeta1-Smad3 signalling pathway. (2010) (196)
- Small Molecule Inhibitors Targeting Activator Protein 1 (AP-1) (2014) (164)
- TRPM7 mediates breast cancer cell migration and invasion through the MAPK pathway. (2013) (124)
- Gemcitabine treatment promotes pancreatic cancer stemness through the Nox/ROS/NF-κB/STAT3 signaling cascade. (2016) (119)
- Up‐regulation of glycolysis promotes the stemness and EMT phenotypes in gemcitabine‐resistant pancreatic cancer cells (2017) (103)
- Myosin Light Chain Kinase Signaling in Endothelial Barrier Dysfunction (2013) (103)
- Discovery of O-Alkylamino Tethered Niclosamide Derivatives as Potent and Orally Bioavailable Anticancer Agents. (2013) (102)
- Effect of cadmium on oxidative stress and immune function of common carp (Cyprinus carpio L.) by transcriptome analysis. (2017) (100)
- Activation of STAT3 and Bcl-2 and reduction of reactive oxygen species (ROS) promote radioresistance in breast cancer and overcome of radioresistance with niclosamide (2018) (97)
- Novel nitrogen-enriched oridonin analogues with thiazole-fused A-ring: protecting group-free synthesis, enhanced anticancer profile, and improved aqueous solubility. (2013) (94)
- Discovery and development of natural product oridonin-inspired anticancer agents. (2016) (91)
- MUC1 Initiates a Calcium Signal after Ligation by Intercellular Adhesion Molecule-1* (2004) (88)
- Effect of epidermal growth factor receptor inhibitor on development of estrogen receptor-negative mammary tumors. (2004) (87)
- Myricitrin Alleviates Oxidative Stress-induced Inflammation and Apoptosis and Protects Mice against Diabetic Cardiomyopathy (2017) (87)
- Humanized NOD-SCID IL2rg–/– mice as a preclinical model for cancer research and its potential use for individualized cancer therapies. (2014) (85)
- Fragment-based drug design and identification of HJC0123, a novel orally bioavailable STAT3 inhibitor for cancer therapy. (2013) (83)
- cFos is critical for MCF-7 breast cancer cell growth (2005) (80)
- Mitochondrial Ca²⁺ uniporter is critical for store-operated Ca²⁺ entry-dependent breast cancer cell migration. (2015) (80)
- Notch Shapes the Innate Immunophenotype in Breast Cancer. (2017) (79)
- Therapeutic Potential of Oridonin and Its Analogs: From Anticancer and Antiinflammation to Neuroprotection (2018) (78)
- Novel roles of reactive oxygen species in the pathogenesis of acute myeloid leukemia (2013) (75)
- Downregulation of ACE2/Ang-(1-7)/Mas axis promotes breast cancer metastasis by enhancing store-operated calcium entry. (2016) (73)
- Neutrophil transmigration, focal adhesion kinase and endothelial barrier function. (2012) (71)
- Novel Agents for the Prevention of Breast Cancer: Targeting Transcription Factors and Signal Transduction Pathways (2004) (70)
- AP-1 blockade in breast cancer cells causes cell cycle arrest by suppressing G1 cyclin expression and reducing cyclin-dependent kinase activity (2004) (69)
- Chlorpyrifos exposure in common carp (Cyprinus carpio L.) leads to oxidative stress and immune responses (2017) (65)
- Knockdown of lncRNA H19 restores chemo‐sensitivity in paclitaxel‐resistant triple‐negative breast cancer through triggering apoptosis and regulating Akt signaling pathway (2018) (63)
- Oridonin ring A-based diverse constructions of enone functionality: identification of novel dienone analogues effective for highly aggressive breast cancer by inducing apoptosis. (2013) (63)
- MUC1 Initiates Src-CrkL-Rac1/Cdc42–Mediated Actin Cytoskeletal Protrusive Motility after Ligating Intercellular Adhesion Molecule-1 (2008) (62)
- Cardiac Fibrosis Alleviated by Exercise Training Is AMPK-Dependent (2015) (60)
- Targeting STAT3/miR-21 axis inhibits epithelial-mesenchymal transition via regulating CDK5 in head and neck squamous cell carcinoma (2015) (59)
- Notoginsenoside R1 Protects db/db Mice against Diabetic Nephropathy via Upregulation of Nrf2-Mediated HO-1 Expression (2019) (51)
- Mitochondrial calcium uniporter as a target of microRNA-340 and promoter of metastasis via enhancing the Warburg effect (2017) (50)
- Oxidative stress upregulates PDCD4 expression in patients with gastric cancer via miR-21. (2014) (50)
- Effect of lapatinib on the development of estrogen receptor-negative mammary tumors in mice. (2009) (50)
- Endothelial contractile cytoskeleton and microvascular permeability. (2009) (48)
- The rexinoid, bexarotene, prevents the development of premalignant lesions in MMTV-erbB2 mice (2008) (48)
- The Rexinoid LG100268 Prevents the Development of Preinvasive and Invasive Estrogen Receptor–Negative Tumors in MMTV-erbB2 Mice (2007) (47)
- Traditional Chinese medicine targeting apoptotic mechanisms for esophageal cancer therapy (2015) (47)
- Overcoming synthetic challenges of oridonin A-ring structural diversification: regio- and stereoselective installation of azides and 1,2,3-triazoles at the C-1, C-2, or C-3 position. (2013) (47)
- Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3). (2014) (44)
- Tissue Inhibitor of Metalloproteinase-2 Regulates Matrix Metalloproteinase-2–Mediated Endothelial Barrier Dysfunction and Breast Cancer Cell Transmigration through Lung Microvascular Endothelial Cells (2010) (43)
- YC-1 enhances the anti-tumor activity of sorafenib through inhibition of signal transducer and activator of transcription 3 (STAT3) in hepatocellular carcinoma (2014) (43)
- Myricitrin Attenuates High Glucose-Induced Apoptosis through Activating Akt-Nrf2 Signaling in H9c2 Cardiomyocytes (2016) (41)
- ent-Kaurane-based regio- and stereoselective inverse electron demand hetero-Diels-Alder reactions: synthesis of dihydropyran-fused diterpenoids. (2014) (40)
- Peiminine inhibits colorectal cancer cell proliferation by inducing apoptosis and autophagy and modulating key metabolic pathways (2017) (40)
- The AP-1 transcription factor regulates postnatal mammary gland development. (2006) (39)
- Serum metalloproteinases MMP-2, MMP-9, and metalloproteinase tissue inhibitors in patients are associated with arteriovenous fistula maturation. (2010) (36)
- MiR-519d-3p suppresses breast cancer cell growth and motility via targeting LIM domain kinase 1 (2018) (36)
- The microRNAs miR-200b-3p and miR-429-5p target the LIMK1/CFL1 pathway to inhibit growth and motility of breast cancer cells. (2017) (35)
- miR-503-3p induces apoptosis of lung cancer cells by regulating p21 and CDK4 expression. (2017) (35)
- Key role of microRNA-15a in the KLF4 suppressions of proliferation and angiogenesis in endothelial and vascular smooth muscle cells. (2013) (34)
- The rexinoid bexarotene represses cyclin D1 transcription by inducing the DEC2 transcriptional repressor (2011) (34)
- Polydatin down-regulates the phosphorylation level of Creb and induces apoptosis in human breast cancer cell (2017) (34)
- Suppression of the Growth and Invasion of Human Head and Neck Squamous Cell Carcinomas via Regulating STAT3 Signaling and the miR-21/β-catenin Axis with HJC0152 (2017) (33)
- Fibrinogen-&ggr; C-Terminal Fragments Induce Endothelial Barrier Dysfunction and Microvascular Leak via Integrin-Mediated and RhoA-Dependent Mechanism (2009) (33)
- Value of folate receptor-positive circulating tumour cells in the clinical management of indeterminate lung nodules: A non-invasive biomarker for predicting malignancy and tumour invasiveness (2019) (32)
- ROS/KRAS/AMPK Signaling Contributes to Gemcitabine-Induced Stem-like Cell Properties in Pancreatic Cancer (2019) (32)
- The microRNA miR-181c enhances chemosensitivity and reduces chemoresistance in breast cancer cells via down-regulating osteopontin. (2019) (32)
- The microRNAs miR-200b-3p and miR-429-5p target the LIMK1/CFL1 pathway to inhibit growth and motility of breast cancer cells (2017) (31)
- Transgenic mouse models for the prevention of breast cancer. (2005) (30)
- Discovery and Development of Natural Product Oridonin‐Inspired Anticancer Agents (2016) (29)
- Targeting the NRF-2/RHOA/ROCK signaling pathway with a novel aziridonin, YD0514, to suppress breast cancer progression and lung metastasis. (2018) (28)
- Oridonin and its derivatives for cancer treatment and overcoming therapeutic resistance (2020) (28)
- N6-Methyladenosine Induced miR-34a-5p Promotes TNF-α-Induced Nucleus Pulposus Cell Senescence by Targeting SIRT1 (2021) (28)
- High glucose promotes pancreatic cancer cells to escape from immune surveillance via AMPK-Bmi1-GATA2-MICA/B pathway (2019) (27)
- Distinct actions of intermittent and sustained β-adrenoceptor stimulation on cardiac remodeling (2011) (27)
- Dendritic Cells Loaded with Pancreatic Cancer Stem Cells (CSCs) Lysates Induce Antitumor Immune Killing Effect In Vitro (2014) (26)
- Metformin attenuates angiotensin II‐induced TGFβ1 expression by targeting hepatocyte nuclear factor‐4‐α (2018) (26)
- Regio- and Stereospecific Synthesis of Oridonin D-Ring Aziridinated Analogues for the Treatment of Triple-Negative Breast Cancer via Mediated Irreversible Covalent Warheads. (2018) (25)
- Scavenger Receptor Class B Type 1 Deletion Led to Coronary Atherosclerosis and Ischemic Heart Disease in Low-density Lipoprotein Receptor Knockout Mice on Modified Western-type Diet (2017) (25)
- Rexinoid-induced Expression of IGFBP-6 Requires RARβ-dependent Permissive Cooperation of Retinoid Receptors and AP-1* (2009) (25)
- NEK2 promotes proliferation, migration and tumor growth of gastric cancer cells via regulating KDM5B/H3K4me3. (2019) (24)
- Targeting the Activator Protein 1 Transcription Factor for the Prevention of Estrogen Receptor–Negative Mammary Tumors (2008) (23)
- Exendin-4 promotes the vascular smooth muscle cell re-differentiation through AMPK/SIRT1/FOXO3a signaling pathways. (2018) (23)
- Qigesan inhibits migration and invasion of esophageal cancer cells via inducing connexin expression and enhancing gap junction function. (2016) (22)
- Cancer-derived exosome miRNAs induce skeletal muscle wasting by Bcl-2-mediated apoptosis in colon cancer cachexia (2021) (22)
- HJC0152 suppresses human non–small‐cell lung cancer by inhibiting STAT3 and modulating metabolism (2020) (20)
- Exacerbated cardiac fibrosis induced by β‐adrenergic activation in old mice due to decreased AMPK activity (2016) (20)
- Bmi1 inhibition enhances the sensitivity of pancreatic cancer cells to gemcitabine (2016) (20)
- Low Concentration of Caffeine Inhibits the Progression of the Hepatocellular Carcinoma via Akt Signaling Pathway. (2015) (19)
- TNF-α induces apoptosis of human nucleus pulposus cells via activating the TRIM14/NF-κB signalling pathway (2019) (19)
- Role of Non‐muscle Myosin Light Chain Kinase in Neutrophil‐mediated Intestinal Barrier Dysfunction During Thermal Injury (2010) (18)
- Combination chemotherapy of valproic acid (VPA) and gemcitabine regulates STAT3/Bmi1 pathway to differentially potentiate the motility of pancreatic cancer cells (2019) (16)
- Calcium-sensing stromal interaction molecule 2 upregulates nuclear factor of activated T cells 1 and transforming growth factor-β signaling to promote breast cancer metastasis (2019) (15)
- Inhibition of 5‐Hydroxytryptamine Receptor 2B Reduced Vascular Restenosis and Mitigated the β‐Arrestin2–Mammalian Target of Rapamycin/p70S6K Pathway (2018) (15)
- Targeting γ-secretase in breast cancer. (2012) (15)
- Notch Signaling and the Breast Cancer Microenvironment. (2021) (15)
- Vein Tissue Expression of Matrix Metalloproteinase as Biomarker for Hemodialysis Arteriovenous Fistula Maturation (2010) (14)
- A novel STAT3 inhibitor, HJC0152, exerts potent antitumor activity in glioblastoma. (2019) (14)
- ICAM‐1 Activates Platelets and Promotes Endothelial Permeability through VE‐Cadherin after Insufficient Radiofrequency Ablation (2021) (14)
- Establishment of a mouse model of cancer cachexia with spleen deficiency syndrome and the effects of atractylenolide I (2019) (14)
- Exploring cisplatin resistance in ovarian cancer through integrated bioinformatics approach and overcoming chemoresistance with sanguinarine. (2020) (13)
- GDF-15 in tumor-derived exosomes promotes muscle atrophy via Bcl-2/caspase-3 pathway (2022) (10)
- Structure-activity relationship studies on Bax activator SMBA1 for the treatment of ER-positive and triple-negative breast cancer. (2019) (9)
- Gpihbp1 deficiency accelerates atherosclerosis and plaque instability in diabetic Ldlr-/- mice. (2019) (8)
- MUC 1 Initiates Src-CrkL-Rac 1 / Cdc 42 – Mediated Actin Cytoskeletal Protrusive Motility after Ligating Intercellular Adhesion Molecule-1 (2008) (8)
- The critical role of STAT3 in biogenesis of tumor-derived exosomes with potency of inducing cancer cachexia in vitro and in vivo (2022) (8)
- Macranthoidin B Modulates Key Metabolic Pathways to Enhance ROS Generation and Induce Cytotoxicity and Apoptosis in Colorectal Cancer (2018) (7)
- The microRNAs miR-200 b-3 p and miR-429-5 p target the LIMK 1 / CFL 1 pathway to inhibit growth and motility of breast cancer cells (2017) (7)
- SiBaoChongCao exhibited anti-fatigue activities and ameliorated cancer cachexia in mice (2019) (6)
- MiR-519d-3p suppresses breast cancer cell growth and motility via targeting LIM domain kinase 1 (2017) (5)
- Deficiency of scavenger receptor class B type 1 leads to increased atherogenesis with features of advanced fibroatheroma and expansive arterial remodeling. (2017) (5)
- Mechanistic Evaluation and Translational Signature of Gemcitabine-induced Chemoresistance by Quantitative Phosphoproteomics Analysis with iTRAQ Labeling Mass Spectrometry (2017) (5)
- Efficacy and Safety of Nedaplatin in Advanced Breast Cancer Therapy (2016) (5)
- Comparable Responses in Male and Female Mice to Cerulein-Induced Chronic Pancreatic Injury and Recovery. (2018) (4)
- High glucose promotes pancreatic cancer cells to escape from immune surveillance via AMPK-Bmi1-GATA2-MICA/B pathway (2019) (3)
- Hyperglycemia Enhances Immunosuppression and Aerobic Glycolysis of Pancreatic Cancer Through Upregulating Bmi1-UPF1-HK2 Pathway (2022) (3)
- The Rexinoid LG 100268 Prevents the Development of Preinvasive and Invasive Estrogen Receptor ^ NegativeTumors in MMTV-erbB 2 Mice (2007) (3)
- Pancreatic stromal Gremlin 1 expression during pancreatic tumorigenesis (2020) (3)
- Further lead optimization on Bax activators: Design, synthesis and pharmacological evaluation of 2-fluoro-fluorene derivatives for the treatment of breast cancer. (2021) (3)
- miR-21 targets MMP-7 and promotes perineural invasion of cholangiocarcinoma (2017) (2)
- Abstract 3: Discovery and optimization of small molecule Bax activators for cancer therapy (2019) (2)
- Identifying microRNA biomarkers and constructing microRNA-regulated networks in coronary artery diseases : a meta-analysis (2019) (2)
- MicroRNA-137 inhibits apoptosis of neuron cells in injured spinal cord by targeting calpain 2 (2016) (2)
- Characteristic pancreatic and splenic immune cell infiltration patterns in mouse acute pancreatitis (2021) (2)
- Abstract P6-12-04: Targeting STAT3 with novel small molecule inhibitors to sensitize breast cancer cells to radiation therapy (2015) (1)
- Abstract B85: Role of the TASK2 in regulating breast cancer cell proliferation (2011) (1)
- Abstract 9: Suppression of the invasion and growth of human head and neck squamous cell carcinomas via regulating STAT3 signaling and miR-21/β-catenin axis with HJC0152 (2017) (1)
- Abstract 5066: Chemoprevention of breast cancer by targeting glucose metabolism with HJC0152 (2019) (1)
- Tumor‐derived TIMP‐2 mediates endothelial barrier dysfunction and breast cancer cell transmigration by activating endothelial MMP‐2 (2010) (1)
- Abstract P1-02-08: Reprogramming glucose metabolism and energy production in breast cancer cells (2018) (1)
- AP-1 blockade in vivo suppresses development of mammary tumor im MMTV- erbB2 mice (2006) (0)
- Abstract 19: Examination of HJC0152, a putative modulator of glucose and energy metabolism, for mammary cancer prevention (2020) (0)
- Mechanistic Evaluation and Translational Signature of Gemcitabine-induced Chemoresistance by Quantitative Phosphoproteomics Analysis with iTRAQ Labeling Mass Spectrometry (2017) (0)
- Targeting STAT3/miR-21 axis inhibits epithelial-mesenchymal transition via regulating CDK5 in head and neck squamous cell carcinoma (2015) (0)
- Abstract 1239: Putative Bax activators GL0385 and GL0388 for targeted breast cancer therapy (2021) (0)
- Abstract A95: KCNK5 regulates proliferation of ER-negative breast cancer cells (2010) (0)
- Abstract 3940: Novel Bax activators for targeted breast cancer therapy (2022) (0)
- Abstract 1238: Treating estrogen receptor (ER)-negative and triple-negative breast cancer by targeting STAT3 signaling with putative STAT3 inhibitors (2021) (0)
- Abstract 4883: Suppression of breast cancer by reprogramming glucose metabolism and energy production with HJC0152 (2018) (0)
- Abstract 5101: Inhibition of Notch reverses immunosuppression in basal-like breast cancer (2023) (0)
- Abstract 3805: Anticancer agent HJC0416 inhibits the growth of breast cancer xenografts via downregulating STAT3 signaling (2014) (0)
- Blockade of the AP-1 transcription factor prevents wnt1-induced, but not c-myc-induced mammary tumors in mice (2007) (0)
- Abstract 329: Reprogramming glucose metabolism and energy production with a small molecule HJC0152 suppresses breast cancer development and progression to metastasis (2016) (0)
- QS424. Matrix Metalloproteinase (MMP) Expression in Arteriovenous Fistula (AVF) Maturation for Hemodialysis (2009) (0)
- Monocyte adhesion and endothelial hyperpermeability are associated with failure of arteriovenous fistula (AVF) maturation for hemodialysis access (2010) (0)
- Abstract 5317: Photonic crystal microarray sensing of breast cancer cell line lysates (2014) (0)
- Abstract 2267: Natural product-inspired drug discovery: Chemistry and biology of oridonin analogs with unique scaffolds and enhanced anticancer profiles . (2013) (0)
- Abstract B63: Developing Novel STAT3 Inhibitors for the Treatment and Prevention of Cancer (2012) (0)
- Breast Cancer : Targets and Therapy Targeting γ-secretase in breast cancer (2012) (0)
- Increased Monocyte-Endothelial Cell Dysfunction in Patients With Peripheral Vascular Disease (PVD) Versus Patients With Abdominal Aortic Aneurysms (AAA) (2012) (0)
- Calcium-sensing stromal interaction molecule 2 upregulates nuclear factor of activated T cells 1 and transforming growth factor-β signaling to promote breast cancer metastasis (2019) (0)
- Abstract P6-03-19: Oridonalogs reverse chemoresistance in breast cancer cells by targeting STAT3 (2020) (0)
- Abstract 424: Development of HJC0152-based proteolysis-targeting chimera degraders for breast cancer therapy (2022) (0)
- METTL3 Regulates m6A Modification of ID2 mRNA to Promote Pancreatic Cancer Development (2022) (0)
- Structure-activity relationship studies on O-alkylamino-tethered salicylamide derivatives with various amino acid linkers as potent anticancer agents. (2022) (0)
- Exploring immune interactions in triple negative breast cancer: IL-1β inhibition and its therapeutic potential (2023) (0)
- Cellular crosstalk mediating immune evasion in pancreatic cancer microenvironment (2019) (0)
- Combination chemotherapy of valproic acid (VPA) and gemcitabine regulates STAT3/Bmi1 pathway to differentially potentiate the motility of pancreatic cancer cells (2019) (0)
- Abstract P2-06-13: A novel small molecule JMX0293 inhibits the growth of triple-negative breast cancer via suppressing STAT3 and inducing apoptosis (2019) (0)
- Abstract P5-21-19: Suppression of breast carcinogenesis and metastasis by targeting glucose metabolism with HJC0152 (2018) (0)
- Abstract LB-299: Glucose metabolism modulator HJC0152 differentially regulates glycolytic enzymes to suppress breast carcinogenesis (2017) (0)
- Additional file 3: Figure S1. of Targeting STAT3/miR-21 axis inhibits epithelial-mesenchymal transition via regulating CDK5 in head and neck squamous cell carcinoma (2015) (0)
- Abstract B33: Target STAT3 signaling for the prevention of ER-negative breast cancer (2013) (0)
- Abstract 872: Novel potent and orally active STAT3 inhibitors for cancer therapies. (2013) (0)
- THE C‐TERMINAL GLOBULAR DOMAIN OF FIBRINOGEN γ CHAIN INDUCES ENDOTHELIAL BARRIER DYSFUNCTION AND MICROVASCULAR LEAKAGE VIA A RHOA‐DEPENDENT MECHANISM (2009) (0)
- Abstract B82: The TASK2 potassium ion channel is differentially expressed in ER-negative breast cancer (2010) (0)
- Abstract 5573: Discovery of potent oridonin derivatives for the treatment of breast cancer. (2013) (0)
- Dihydromyricetin ameliorates osteogenic differentiation of human aortic valve interstitial cells by targeting c-KIT/interleukin-6 signaling pathway (2022) (0)
- YC-1 enhances the anti-tumor activity of sorafenib through inhibition of signal transducer and activator of transcription 3 (STAT3) in hepatocellular carcinoma (2014) (0)
- AP-1 blockade prevents breast cancer development by suppressing cyclin D and E2F factors. (2006) (0)
- ROS/KRAS/AMPK signaling determines gemcitabine-induced pancreatic cancer stem-like cell property in vitro (2018) (0)
- Abstract P3-06-09: Discovery of novel oridonin-derivatives for the treatment of metastatic breast cancer (2018) (0)
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What Schools Are Affiliated With Qiang Shen?
Qiang Shen is affiliated with the following schools:
