Qiang Yu
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Qiang Yubiology Degrees
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Computational Biology
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Biology
Qiang Yu's Degrees
- PhD Biochemistry University of California, Berkeley
- Masters Molecular Biology Stanford University
- Bachelors Biology Peking University
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(Suggest an Edit or Addition)Qiang Yu's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- A Global Map of p53 Transcription-Factor Binding Sites in the Human Genome (2006) (1172)
- Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. (2007) (887)
- Glycine Decarboxylase Activity Drives Non-Small Cell Lung Cancer Tumor-Initiating Cells and Tumorigenesis (2012) (344)
- Context-specific regulation of NF-κB target gene expression by EZH2 in breast cancers. (2011) (342)
- Glycine Decarboxylase Activity Drives Non-Small Cell Lung Cancer Tumor-Initiating Cells and Tumorigenesis (2012) (321)
- miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A. (2009) (261)
- Inhibitors of histone deacetylases target the Rb-E2F1 pathway for apoptosis induction through activation of proapoptotic protein Bim. (2005) (251)
- DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications. (2008) (227)
- The histone methyltransferase inhibitor, DZNep, up-regulates TXNIP, increases ROS production, and targets leukemia cells in AML. (2010) (206)
- Methionine is a metabolic dependency of tumor-initiating cells (2019) (173)
- UCN-01 inhibits p53 up-regulation and abrogates gamma-radiation-induced G(2)-M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1. (2002) (165)
- Hypoxic tumor microenvironment activates GLI2 via HIF-1α and TGF-β2 to promote chemoresistance in colorectal cancer (2018) (157)
- FOXQ1 regulates epithelial-mesenchymal transition in human cancers. (2011) (152)
- p53-regulated Transcriptional Program Associated with Genotoxic Stress-induced Apoptosis* (2004) (151)
- CDKN1C (p57KIP2) Is a Direct Target of EZH2 and Suppressed by Multiple Epigenetic Mechanisms in Breast Cancer Cells (2009) (141)
- Pharmacologic modulation of glycogen synthase kinase-3beta promotes p53-dependent apoptosis through a direct Bax-mediated mitochondrial pathway in colorectal cancer cells. (2005) (132)
- IRAK1 is a therapeutic target that drives breast cancer metastasis and resistance to paclitaxel (2015) (128)
- EZH2 overexpression in natural killer/T-cell lymphoma confers growth advantage independently of histone methyltransferase activity. (2013) (127)
- BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A (2009) (124)
- PDK1 signaling toward PLK1-MYC activation confers oncogenic transformation, tumor-initiating cell activation, and resistance to mTOR-targeted therapy. (2013) (119)
- Arginine methylation-dependent reader-writer interplay governs growth control by E2F-1. (2013) (117)
- Heparan sulfate-FGF10 interactions during lung morphogenesis. (2003) (115)
- B55β-associated PP2A complex controls PDK1-directed myc signaling and modulates rapamycin sensitivity in colorectal cancer. (2010) (114)
- Differentially expressed gene profiles between multidrug resistant gastric adenocarcinoma cells and their parental cells. (2002) (105)
- Chromosome 1q21.3 amplification is a trackable biomarker and actionable target for breast cancer recurrence (2017) (104)
- EZH2 phosphorylation by JAK3 mediates a switch to noncanonical function in natural killer/T-cell lymphoma. (2016) (103)
- TXNIP (VDUP-1, TBP-2): a major redox regulator commonly suppressed in cancer by epigenetic mechanisms. (2011) (99)
- Altered regulation of Src upon cell detachment protects human lung adenocarcinoma cells from anoikis (2004) (93)
- Impact of p53 knockout and topotecan treatment on gene expression profiles in human colon carcinoma cells: a pharmacogenomic study. (2003) (90)
- VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma. (2017) (89)
- Inhibition of interleukin-1 receptor-associated kinase 1 (IRAK1) as a therapeutic strategy (2018) (88)
- EZH2-mediated inactivation of IFN-γ-JAK-STAT1 signaling is an effective therapeutic target in MYC-driven prostate cancer. (2014) (83)
- Antisense inhibition of Chk2/hCds1 expression attenuates DNA damage‐induced S and G2 checkpoints and enhances apoptotic activity in HEK‐293 cells (2001) (83)
- Mitochondrial electron transport chain complex III is required for antimycin A to inhibit autophagy. (2011) (82)
- IGF‐1 induces Pin1 expression in promoting cell cycle S‐phase entry (2002) (78)
- Restoring p53-mediated apoptosis in cancer cells: new opportunities for cancer therapy. (2006) (75)
- The E2F family and the role of E2F1 in apoptosis. (2009) (75)
- Topotecan is a substrate for multidrug resistance associated protein 4. (2006) (73)
- TP53 Genomic Status Regulates Sensitivity of Gastric Cancer Cells to the Histone Methylation Inhibitor 3-Deazaneplanocin A (DZNep) (2012) (69)
- Saturated Fatty Acids Modulate Cell Response to DNA Damage: Implication for Their Role in Tumorigenesis (2008) (66)
- Combinatorial pharmacologic approaches target EZH2-mediated gene repression in breast cancer cells (2009) (65)
- Nanoscale chromatin profiling of gastric adenocarcinoma reveals cancer-associated cryptic promoters and somatically acquired regulatory elements (2014) (65)
- RASAL2 activates RAC1 to promote triple-negative breast cancer progression. (2014) (64)
- Apoptosis Signal-regulating Kinase 1 Is a Direct Target of E2F1 and Contributes to Histone Deacetylase Inhibitorinduced Apoptosis through Positive Feedback Regulation of E2F1 Apoptotic Activity* (2006) (62)
- Pericyte-targeting prodrug overcomes tumor resistance to vascular disrupting agents. (2017) (62)
- Anchorage‐independent phosphorylation of p130Cas protects lung adenocarcinoma cells from anoikis (2002) (60)
- Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway (2020) (59)
- Transmembrane tyrosine phosphatase LAR induces apoptosis by dephosphorylating and destabilizing p130Cas (1999) (59)
- Overexpression of the transmembrane tyrosine phosphatase LAR activates the caspase pathway and induces apoptosis (1998) (57)
- Ribosomal protein S27-like, a p53-inducible modulator of cell fate in response to genotoxic stress. (2007) (56)
- Protein tyrosine phosphatase UBASH3B is overexpressed in triple-negative breast cancer and promotes invasion and metastasis (2013) (54)
- Expression of inwardly rectifying potassium channels (GIRKs) and beta-adrenergic regulation of breast cancer cell lines (2004) (54)
- HIFI-α activation underlies a functional switch in the paradoxical role of Ezh2/PRC2 in breast cancer (2016) (52)
- MiR-136 targets E2F1 to reverse cisplatin chemosensitivity in glioma cells (2014) (50)
- Bcl-2, via Its BH4 Domain, Blocks Apoptotic Signaling Mediated by Mitochondrial Ras* (2003) (50)
- The expression pattern of long non-coding RNA PVT1 in tumor tissues and in extracellular vesicles of colorectal cancer correlates with cancer progression (2017) (50)
- Heparan sulfates expressed in the distal lung are required for Fgf10 binding to the epithelium and for airway branching. (2003) (49)
- A crucial role for bone morphogenetic protein-Smad1 signalling in the DNA damage response (2012) (47)
- Dual Regulation of Cdc25A by Chk1 and p53-ATF3 in DNA Replication Checkpoint Control* (2009) (46)
- Distinctive regulation and function of PI 3K/Akt and MAPKs in doxorubicin‐induced apoptosis of human lung adenocarcinoma cells (2004) (46)
- Matrine induces RIP3-dependent necroptosis in cholangiocarcinoma cells (2017) (44)
- Study of the PTEN gene expression and FAK phosphorylation in human hepatocarcinoma tissues and cell lines (2004) (42)
- miR-449 regulates CDK-Rb-E2F1 through an auto-regulatory feedback circuit (2010) (41)
- Cleavage of p130Cas in anoikis (2004) (41)
- Heterogeneous epigenetic regulation of TIMP3 in prostate cancer (2012) (38)
- Inhibition of STAT3/cyclinD1 pathway promotes chemotherapeutic sensitivity of colorectal caner. (2015) (37)
- Determinants of Sensitivity to DZNep Induced Apoptosis in Multiple Myeloma Cells (2011) (37)
- Elevated expression of long intergenic non‐coding RNA HOTAIR in a basal‐like variant of MCF‐7 breast cancer cells (2015) (37)
- miR-517a is an independent prognostic marker and contributes to cell migration and invasion in human colorectal cancer. (2016) (34)
- The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival. (2018) (33)
- Preclinical pharmacokinetic studies of 3-deazaneplanocin A, a potent epigenetic anticancer agent, and its human pharmacokinetic prediction using GastroPlus™. (2015) (33)
- Molecular mechanisms of tumor resistance to PI3K-mTOR-targeted therapy (2013) (32)
- A systematic benchmark of Nanopore long read RNA sequencing for transcript level analysis in human cell lines (2021) (31)
- Specific inhibition of FGF-induced MAPK activation by the receptor-like protein tyrosine phosphatase LAR (2000) (31)
- Identification of Myc-mediated Death Response Pathways by Microarray Analysis* (2002) (29)
- Wedelolactone, a Naturally Occurring Coumestan, Enhances Interferon-γ Signaling through Inhibiting STAT1 Protein Dephosphorylation* (2013) (28)
- A p53-independent G1 Cell Cycle Checkpoint Induced by the Suppression of Protein Kinase C α and θ Isoforms* (2003) (28)
- KDM6B Counteracts EZH2-Mediated Suppression of IGFBP5 to Confer Resistance to PI3K/AKT Inhibitor Treatment in Breast Cancer (2018) (27)
- A truncated cytoplasmic topoisomerase IIα in a drug‐resistant lung cancer cell line is encoded by a TOP2A allele with a partial deletion of exon 34 (2000) (27)
- A BRIEF HISTORY OF CANCER CHEMOTHERAPY (2002) (26)
- MiR-200a Regulates CDK4/6 Inhibitor Effect by Targeting CDK6 in Metastatic Melanoma. (2017) (26)
- The KDM2B- Let-7b -EZH2 Axis in Myelodysplastic Syndromes as a Target for Combined Epigenetic Therapy (2014) (26)
- KDM4B-regulated unfolded protein response as a therapeutic vulnerability in PTEN-deficient breast cancer (2018) (26)
- Sodium 4‐phenylbutyrate induces apoptosis of human lung carcinoma cells through activating JNK pathway (2004) (26)
- c-Myc overexpression sensitizes Bim-mediated Bax activation for apoptosis induced by histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) through regulating Bcl-2/Bcl-xL expression. (2007) (25)
- ULK1 phosphorylates Exo70 to suppress breast cancer metastasis (2020) (25)
- Polyphyllin D induces apoptosis in U87 human glioma cells through the c-Jun NH2-terminal kinase pathway. (2014) (25)
- Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer (2021) (24)
- Mesenchymal Stem Cell-Secreted Exosome Promotes Chemoresistance in Breast Cancer via Enhancing miR-21-5p-Mediated S100A6 Expression (2020) (24)
- Susceptibility to cell death induced by blockade of MAPK pathway in human colorectal cancer cells carrying Ras mutations is dependent on p53 status. (2004) (23)
- The prognostic value of a seven-microRNA classifier as a novel biomarker for the prediction and detection of recurrence in glioma patients (2016) (23)
- 3‐Deazaneplanocin A and Neplanocin A Analogues and Their Effects on Apoptotic Cell Death (2015) (20)
- EZH2-mediated PP2A inactivation confers resistance to HER2-targeted breast cancer therapy (2020) (19)
- A new tumor suppressor lncRNA RP11-190D6.2 inhibits the proliferation, migration, and invasion of epithelial ovarian cancer cells (2017) (18)
- E2F1-mediated apoptosis as a target of cancer therapy. (2009) (18)
- Loading 3-deazaneplanocin A into pegylated unilamellar liposomes by forming transient phenylboronic acid-drug complex and its pharmacokinetic features in Sprague-Dawley rats. (2012) (18)
- A p53-independent G1 cell cycle checkpoint induced by the suppression of protein kinase C alpha and theta isoforms. (2003) (17)
- Functional Characterization of D9, a Novel Deazaneplanocin A (DZNep) Analog, in Targeting Acute Myeloid Leukemia (AML) (2015) (16)
- Hypoxia induces HIF1α-dependent epigenetic vulnerability in triple negative breast cancer to confer immune effector dysfunction and resistance to anti-PD-1 immunotherapy (2022) (15)
- Colorectal cancer-associated fibroblasts promote metastasis by up-regulating LRG1 through stromal IL-6/STAT3 signaling (2021) (15)
- HER2-L755S mutation induces hyperactive MAPK and PI3K-mTOR signaling, leading to resistance to HER2 tyrosine kinase inhibitor treatment (2019) (12)
- Inhibition of the PLK1‐Coupled Cell Cycle Machinery Overcomes Resistance to Oxaliplatin in Colorectal Cancer (2021) (12)
- Two closely related receptor‐type tyrosine phosphatases are differentially expressed during rat lung development (1995) (12)
- Knockdown of a DIS3L2 promoter upstream long noncoding RNA (AC105461.1) enhances colorectal cancer stem cell properties in vitro by down-regulating DIS3L2 (2017) (10)
- CHAPTER 2 – NOVEL TARGETS IN THE CELL CYCLE AND CELL CYCLE CHECKPOINTS (2002) (10)
- Quantification of 3-deazaneplanocin A, a novel epigenetic anticancer agent, in rat biosamples by hydrophilic interaction liquid chromatography-tandem mass spectrometric detection. (2011) (9)
- Targeting the IRAK1–S100A9 Axis Overcomes Resistance to Paclitaxel in Nasopharyngeal Carcinoma (2021) (8)
- Circ_0000520 contributes to triple‐negative breast cancer progression through mediating the miR‐1296/ZFX axis (2021) (8)
- Cancer gene silencing without DNA hypermethylation (2008) (8)
- Epidermal growth factor receptor somatic mutation analysis in 354 Chinese patients with non-small cell lung cancer (2017) (8)
- EGFR inhibitor enhances cisplatin sensitivity of human glioma cells (2011) (7)
- Correction: CDKN1C (p57KIP2) Is a Direct Target of EZH2 and Suppressed by Multiple Epigenetic Mechanisms in Breast Cancer Cells (2009) (7)
- Interleukin enhancer‐binding factor 2 promotes cell proliferation and DNA damage response in metastatic melanoma (2021) (7)
- EZH 2 phosphorylation by JAK 3 mediates a switch to non-canonical function in Natural Killer / T-cell Lymphoma (2016) (6)
- RASAL 2 activates RAC 1 to promote triple-negative breast cancer progression (6)
- Molecular switch of EZH2 in hypoxia (2016) (5)
- CREBBP cooperates with the cell cycle machinery to attenuate chidamide sensitivity in relapsed/refractory diffuse large B-cell lymphoma. (2021) (5)
- Targeting enhancer reprogramming to mitigate MEK inhibitor resistance in preclinical models of advanced ovarian cancer. (2021) (5)
- LncRNA FAM66C inhibits pancreatic cancer progression by sponging miR-574-3p (2020) (4)
- Studies of the Efficacy of Low-Dose Apatinib Monotherapy as Third-Line Treatment in Patients with Metastatic Colorectal Cancer and Apatinib’s Novel Anticancer Effect by Inhibiting Tumor-Derived Exosome Secretion (2022) (4)
- Tumor Necrosis Factor-Alpha and Apoptosis Induction in Melanoma Cells through Histone Modification by 3-Deazaneplanocin A (2013) (4)
- IFI16-dependent STING signaling is a crucial regulator of anti-HER2 immune response in HER2+ breast cancer (2022) (4)
- Knockdown of a Dis 3 l 2 promoter upstream long noncoding rna ( ac 105461 . 1 ) enhances colorectal cancer stem cell properties in vitro by down-regulating Dis 3 l 2 (2017) (3)
- PDK1-driven Myc signaling regulates cellular response to mTOR inhibitors (2011) (3)
- [The effects of PTEN gene on migration and FAK phosphorylation of SMMC-7721 human hepatocarcinoma cell line]. (2003) (3)
- EZH 2 overexpression in natural killer / T-cell lymphoma confers growth advantage independently of histone methyltransferase activity Running Title : EZH 2 in natural killer / T-cell lymphoma (2013) (3)
- Correction: Corrigendum: IRAK1 is a therapeutic target that drives breast cancer metastasis and resistance to paclitaxel (2015) (2)
- Cancer-associated fibroblasts as accomplices to confer therapeutic resistance in cancer (2022) (2)
- Intimate communications within the tumor microenvironment: stromal factors function as an orchestra (2023) (2)
- Publisher Correction: Methionine is a metabolic dependency of tumor-initiating cells (2019) (1)
- Targeting PSAT1 to mitigate metastasis in tumors with p53-72Pro variant (2023) (1)
- Synthetic lethality targeting LKB1 mutant and EGFR wild type human non-small cell lung cancer cells by glucose starvation and SGLT2 inhibition (2019) (1)
- Increased γ-glutamyl transferase positively contributed to the poor prognosis in lung cancer patients (2018) (1)
- [Effects of different statin regimens on lipid profile and serum metalloproteinases in patients with coronary heart disease]. (2009) (1)
- [Relationship between protein tyrosine phosphorylation level and anoikis resistance of breast tumor cell lines]. (2004) (1)
- Knockdown of GALNT7 promotes cell apoptosis and autophagy of breast cancer cells by inactivation of STAT3 (2022) (0)
- Molecular mechanisms of the gastric cancer cells resisting anoikis (2004) (0)
- Abstract 3233: Interleukin enhancer-binding factor 2 amplification controls mRNA stability and enhances DNA damage response in metastatic melanoma (2022) (0)
- Systems Pharmacology in Cancer (2010) (0)
- Abstract B039: KDM4B inhibition confers suseptibility to PI3K inhibitor in PTEN-deficient TNBC through overactivating UPR pathway (2018) (0)
- Predictive Biomarkers and Personalized Medicine TP 53 GenomicStatusRegulates Sensitivity of GastricCancer Cells to the HistoneMethylation Inhibitor 3-Deazaneplanocin A ( DZNep ) (2012) (0)
- RAD21 amplification epigenetically suppresses interferon signaling to promote immune evasion in ovarian cancer (2022) (0)
- Molecular analysis of non small cell lung cancer in Chinese (2016) (0)
- Pharmacogenomic Study Expression Profiles in Human Colon Carcinoma Cells : A Impact of p 53 Knockout and Topotecan Treatment on Gene Updated (2003) (0)
- EZH2 Is Aberrantly Expressed and Plays a Pro-Proliferative Role Independent of Its Methyltransferase Activity in Natural Killer/T-Cell Lymphoma (2012) (0)
- TREATMENT BY MODULATING THE ACTIVITY OF ANUCLECACIDENCODING RPS27L PROTEIN (2017) (0)
- Overexpression of hyaluronan-binding protein 1 promotes the proliferation, migration, and invasion of malignant glioma (2020) (0)
- Function of FasL Reverse Signaling in Survival and Growth of Breast Cancer Cells (2002) (0)
- ULK1 phosphorylates Exo70 to suppress breast cancer metastasis (2020) (0)
- 1 VHL deficiency drives enhancer activation of oncogenes in clear cell renal cell carcinoma (2017) (0)
- ' s report Title : EMT is the Dominant Program in Human Colon Cancer Version : 2 Date : 10 September 2010 (0)
- 562 Two C-terminal truncated cytoplasmic forms of topoisomerase IIα in the VP-16 selected lung cancer cell line, H209V6, have lost bipartite nuclear localization signal(s) and result from partial gene deletion and alternative splicing (1997) (0)
- Abstract 402: Tumor necrosis factor-alpha and apoptosis induction in melanoma cells through histones modification by 3-deazaneplanocin A (2014) (0)
- Targeting Epigenetic Process for Therapeutic Control of Wnt/beta-catenin Signaling in Colorectal Cancer (2007) (0)
- Methionine is a metabolic dependency of tumor-initiating cells (2019) (0)
- Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway (2020) (0)
- LYMPHOID NEOPLASIA EZH2 phosphorylation by JAK3 mediates a switch to noncanonical function in natural killer/T-cell lymphoma (2016) (0)
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