Robert A. Floyd
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Molecular Biology
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Chemistry Biology
Robert A. Floyd's Degrees
- Bachelors Chemistry University of California, Berkeley
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(Suggest an Edit or Addition)Robert A. Floyd's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease. (1991) (1335)
- A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease. (1994) (1105)
- Reactive oxygen species, cell signaling, and cell injury. (2000) (1013)
- Role of oxygen free radicals in carcinogenesis and brain ischemia (1990) (851)
- Antioxidants, oxidative stress, and degenerative neurological disorders. (1999) (840)
- Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia/reperfusion-induced injury to gerbil brain. (1990) (786)
- Oxidative stress in brain aging Implications for therapeutics of neurodegenerative diseases (2002) (783)
- Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone. (1991) (720)
- The role of 8-hydroxyguanine in carcinogenesis. (1990) (707)
- Biomarkers of oxidative stress study II: are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning? (2005) (653)
- Hydroxyl free radical adduct of deoxyguanosine: sensitive detection and mechanisms of formation. (1986) (639)
- Free radical damage to protein and DNA: Mechanisms involved and relevant observations on brain undergoing oxidative stress (1992) (541)
- Electrochemical Analysis of Protein Nitrotyrosine and Dityrosine in the Alzheimer Brain Indicates Region-Specific Accumulation (1998) (501)
- Oxygen free radical involvement in ischemia and reperfusion injury to brain (1988) (440)
- Sensitive assay of hydroxyl free radical formation utilizing high pressure liquid chromatography with electrochemical detection of phenol and salicylate hydroxylation products. (1984) (407)
- Increased oxidative stress and decreased antioxidant defenses in mucosa of inflammatory bowel disease (1996) (403)
- p38 Kinase Is Activated in the Alzheimer's Disease Brain (1999) (355)
- Impairment of cell-mediated immunity functions by dietary zinc deficiency in mice. (1979) (314)
- New perspectives on vitamin E: γ-tocopherol and carboxyethylhydroxychroman metabolites in biology and medicine (2004) (277)
- Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice (2008) (276)
- Neuroinflammatory processes are important in neurodegenerative diseases: an hypothesis to explain the increased formation of reactive oxygen and nitrogen species as major factors involved in neurodegenerative disease development. (1999) (250)
- Association between reactive oxygen species and disease activity in chronic hepatitis C. (1996) (243)
- Reactive oxygen species and protein oxidation in aging: a look back, a look ahead. (2002) (231)
- Damage, Repair, and Mutagenesis in Nuclear Genes after Mouse Forebrain Ischemia–Reperfusion (1996) (230)
- Methylene blue plus light mediates 8-hydroxyguanine formation in DNA. (1989) (208)
- Lipid peroxidation products mediate the formation of 8-hydroxydeoxyguanosine in DNA. (1992) (208)
- Protein modification in aging. (1988) (200)
- Redox regulatory mechanisms of cellular signal transduction. (2000) (197)
- Methylene blue plus light mediates 8-hydroxy 2'-deoxyguanosine formation in DNA preferentially over strand breakage. (1990) (194)
- Nitrones as therapeutics. (2008) (187)
- Message and protein-level elevation of tumor necrosis factor α (TNFα) and TNFα-modulating cytokines in spinal cords of the G93A-SOD1 mouse model for amyotrophic lateral sclerosis (2003) (187)
- Formation of 8-hydroxydeoxyguanosine, hydroxyl free radical adduct of DNA in granulocytes exposed to the tumor promoter, tetradecanoylphorbolacetate. (1986) (186)
- Susceptibility of glutathione peroxidase and glutathione reductase to oxidative damage and the protective effect of spin trapping agents. (1994) (183)
- The presence of two distinct 8-oxoguanine repair enzymes in human cells: their potential complementary roles in preventing mutation. (1998) (175)
- Dietary choline restriction causes complex I dysfunction and increased H(2)O(2) generation in liver mitochondria. (2000) (175)
- Temporal patterns of cytokine and apoptosis-related gene expression in spinal cords of the G93A-SOD1 mouse model of amyotrophic lateral sclerosis. (2002) (175)
- Use of salicylate with high pressure liquid chromatography and electrochemical detection (LCED) as a sensitive measure of hydroxyl free radicals in adriamycin treated rats. (1986) (173)
- An aging Interventions Testing Program: study design and interim report (2007) (171)
- Hydroxyl free radical formation from hydrogen peroxide by ferrous iron-nucleotide complexes. (1983) (162)
- Hydroxyl free radical mediated formation of 8-hydroxyguanine in isolated DNA. (1988) (158)
- Reaction of chromium(VI) with glutathione or with hydrogen peroxide: identification of reactive intermediates and their role in chromium(VI)-induced DNA damage. (1991) (155)
- Spin-trapping of the trichloromethyl radical produced during enzymic NADPH oxidation in the presence of carbon tetrachloride or bromotrichloromethane. (1978) (147)
- Oxidative stress and neuroinflammation in Alzheimer's disease and amyotrophic lateral sclerosis: common links and potential therapeutic targets. (2004) (144)
- Caloric restriction mimetics: metabolic interventions. (2001) (144)
- Formation of reactive oxygen species and of 8-hydroxydeoxyguanosine in DNA in vitro with betel quid ingredients. (1987) (139)
- New perspectives on vitamin E: gamma-tocopherol and carboxyelthylhydroxychroman metabolites in biology and medicine. (2004) (130)
- Oxidative DNA damage in circulating leukocytes occurs as an early event in chronic HCV infection. (1999) (127)
- Interaction of α‐Phenyl‐N‐tert‐Butyl Nitrone and Alternative Electron Acceptors with Complex I Indicates a Substrate Reduction Site Upstream from the Rotenone Binding Site (1998) (126)
- Protein Oxidation in Aging Brain a (1992) (126)
- Regional lipid peroxidation in rat brain in vitro: Possible role of endogenous iron (1985) (124)
- Spin trapping in biological systems. Oxidation of the spin trap 5,5-dimethyl-1-pyrroline-1-oxide by a hydroperoxide-hematin-system. (1977) (123)
- The arachidonic acid 5‐lipoxygenase inhibitor nordihydroguaiaretic acid inhibits tumor necrosis factor α activation of microglia and extends survival of G93A‐SOD1 transgenic mice (2004) (122)
- Redox‐sensitive protein phosphatase activity regulates the phosphorylation state of p38 protein kinase in primary astrocyte culture (1999) (122)
- Hydroxyl free radical reactions with amino acids and proteins studied by electron spin resonance spectroscopy and spin-trapping. (1984) (116)
- The Nitration Product 5-Nitro-γ-tocopherol Is Increased in the Alzheimer Brain (2002) (115)
- Direct demonstration that ferrous ion complexes of di- and triphosphate nucleotides catalyze hydroxyl free radical formation from hydrogen peroxide. (1983) (113)
- Methylene blue photoinactivation of RNA viruses. (2004) (112)
- Message and protein-level elevation of tumor necrosis factor alpha (TNF alpha) and TNF alpha-modulating cytokines in spinal cords of the G93A-SOD1 mouse model for amyotrophic lateral sclerosis. (2003) (110)
- Oxidative damage to behavior during aging. (1991) (110)
- Elevated 8-hydroxydeoxyguanosine levels in DNA of diethylstilbestrol-treated Syrian hamsters: covalent DNA damage by free radicals generated by redox cycling of diethylstilbestrol. (1991) (107)
- DNA-ferrous iron catalyzed hydroxyl free radical formation from hydrogen peroxide. (1981) (106)
- Conditions influencing yield and analysis of 8-hydroxy-2'-deoxyguanosine in oxidatively damaged DNA. (1990) (102)
- Low temperature photo-induced reactions in green leaves and chloroplasts. (1971) (100)
- Protection of methamphetamine nigrostriatal toxicity by dietary selenium (1999) (98)
- Oxidative biochemical markers; clues to understanding aging in long-lived species (2001) (96)
- Reaction of chromium (VI) with hydrogen peroxide in the presence of glutathione: reactive intermediates and resulting DNA damage. (1990) (95)
- Role of chromium(V), glutathione thiyl radical and hydroxyl radical intermediates in Chromium(VI)‐induced DNA Damage (1989) (93)
- Quantitation of protein-bound 3-nitrotyrosine and 3,4-dihydroxyphenylalanine by high-performance liquid chromatography with electrochemical array detection. (1997) (93)
- Anti-inflammatory effects of tocopherol metabolites. (2004) (92)
- Free radicals and cancer (1982) (90)
- Age influence on oxidative events during brain ischemia/reperfusion. (1991) (87)
- Nitrone-based free radical traps as neuroprotective agents in cerebral ischaemia and other pathologies. (1997) (84)
- Production of hydroxyl free radical by brain tissues in hyperglycemic rats subjected to transient forebrain ischemia. (1999) (84)
- Mutations induced by methylene blue plus light in single-stranded M13mp2. (1992) (84)
- Increased oxidative stress brought on by pro-inflammatory cytokines in neurodegenerative processes and the protective role of nitrone-based free radical traps. (1999) (82)
- Reactive oxygen species-mediated inactivation of pyruvate dehydrogenase. (1996) (77)
- Nitrone Inhibition of Age‐Associated Oxidative Damage (2000) (75)
- Formation of long-lived hydroxyl free radical adducts of proline and hydroxyproline in a Fenton reaction. (1984) (73)
- COX-2 inhibition prevents insulin-dependent diabetes in low-dose streptozotocin-treated mice. (2000) (72)
- Peroxidation induced changes in synaptosomal transport of dopamine and γ-aminobutyric acid (1989) (70)
- Free radicals and carcinogenesis. Some properties of the nitroxyl free radicals produced by covalent binding of 2-nitrosofluorene to unsaturated lipids of membranes. (1978) (69)
- Methylene blue and rose bengal photoinactivation of RNA bacteriophages: comparative studies of 8-oxoguanine formation in isolated RNA. (1993) (69)
- Measurement of 3-nitrotyrosine and 5-nitro-gamma-tocopherol by high-performance liquid chromatography with electrochemical detection. (2000) (68)
- Nitrones as therapeutics in age‐related diseases (2006) (67)
- Temporal patterns of cytokine and apoptosis‐related gene expression in spinal cords of the G93A‐SOD1 mouse model of amyotrophic lateral sclerosis (2002) (65)
- Nitrones as Neuroprotectants and Antiaging Drugs (2002) (65)
- Anoxia/reoxygenation induces hydroxyl free radical formation in brain microvessels. (1993) (64)
- Nitrones, their value as therapeutics and probes to understand aging (2002) (62)
- Protective action of nitrone-based free radical traps against oxidative damage to the central nervous system. (1997) (60)
- Translational research involving oxidative stress and diseases of aging. (2011) (60)
- The Role of Metal Ions in Oxidative Processes and Aging (1993) (59)
- Age-dependent changes in rat brain mitochondria of synaptic and non-synaptic origins (1987) (58)
- Nitrone-based therapeutics for neurodegenerative diseases: their use alone or in combination with lanthionines. (2013) (58)
- Anti-cancer activity of nitrones and observations on mechanism of action. (2011) (56)
- Effectiveness of 4-hydroxy phenyl N-tert-butylnitrone (4-OHPBN) alone and in combination with other antioxidant drugs in the treatment of acute acoustic trauma in chinchilla. (2008) (56)
- LINE-1 Hypomethylation in a Choline-Deficiency-Induced Liver Cancer in Rats: Dependence on Feeding Period (2006) (55)
- The nitration product 5-nitro-gamma-tocopherol is increased in the Alzheimer brain. (2002) (55)
- SPIN TRAPPING OF FREE RADICALS PRODUCED FROM NITROSOAMINE CARCINOGENS (1978) (53)
- The human sulfatase 2 inhibitor 2,4‐disulfonylphenyl‐tert‐butylnitrone (OKN‐007) has an antitumor effect in hepatocellular carcinoma mediated via suppression of TGFB1/SMAD2 and Hedgehog/GLI1 signaling (2013) (51)
- Hydroxyl free-radical spin-adduct in rat brain synaptosomes. Observations on the reduction of the nitroxide. (1983) (51)
- Potential Mechanisms of Photodynamic Inactivation of Virus by Methylene Blue I. RNA–Protein Crosslinks and Other Oxidative Lesions in Qβ Bacteriophage (1998) (50)
- Lipid hydroperoxide activation of N-hydroxy-N-acetylaminofluorene via a free radical route. (1976) (49)
- Horseradish peroxidase/hydrogen peroxide-catalyzed oxidation of the carcinogen N-hydroxy-N-acetyl-2-aminofluorene as effected by cyanide and ascorbate. (1976) (48)
- Mediation of 8-hydroxy-guanine formation in DNA by thiazin dyes plus light. (1990) (48)
- Inhibition by phenyl N-tert-butyl nitrone of early phase carcinogenesis in the livers of rats fed a choline-deficient, L-amino acid-defined diet. (1998) (48)
- ADP-iron as a Fenton reactant: radical reactions detected by spin trapping, hydrogen abstraction, and aromatic hydroxylation. (1990) (47)
- α-Phenyl-N-tert-butylnitrone (PBN) Prevents Light-induced Degeneration of the Retina by Inhibiting RPE65 Protein Isomerohydrolase Activity* (2011) (47)
- Protection against oxidative damage to CNS by α-phenyl-tert-butyl nitrone (PBN) and other spin-trapping agents: A novel series of nonlipid free radical scavengers (2008) (47)
- Region‐selective effects of neuroinflammation and antioxidant treatment on peripheral benzodiazepine receptors and NMDA receptors in the rat brain (2002) (46)
- Spin-trapping free radicals in the autooxidation of 6-hydroxydopamine (1979) (45)
- Methylene blue photoinactivation abolishes West Nile virus infectivity in vivo. (2005) (44)
- Reactive oxygen species in choline deficiency induced carcinogenesis and nitrone inhibition (2002) (44)
- Proteins but not nucleic acids are molecular targets for the free radical attack during reoxygenation of rat hepatocytes. (1997) (44)
- Free radical production during ethanol intoxication, dependence, and withdrawal. (1997) (43)
- Is 8-hydroxydeoxyguanosine a mediator of carcinogenesis by a choline-devoid diet in the rat liver? (1990) (43)
- Electron spin resonance spectroscopic demonstration of the hydroxyl free radical scavenger properties of dimethylaminoethanol in spin trapping experiments confirming the molecular basis for the biological effects of centrophenoxine. (1984) (43)
- Ascorbate/iron mediation of hydroxyl free radical damage to PBR322 plasmid DNA. (1988) (41)
- Immuno-spin trapping from biochemistry to medicine: advances, challenges, and pitfalls. Focus on protein-centered radicals. (2014) (41)
- Phenyl-tert-butylnitrone induces tumor regression and decreases angiogenesis in a C6 rat glioma model. (2008) (41)
- A model for beta-amyloid aggregation and neurotoxicity based on the free radical generating capacity of the peptide: implications of "molecular shrapnel" for Alzheimer's disease. (1995) (41)
- Reduced Formation of Oxidative Stress Biomarkers and Migration of Mononuclear Phagocytes in the Cochleae of Chinchilla after Antioxidant Treatment in Acute Acoustic Trauma (2011) (40)
- Increased 8-hydroxyguanine content of chloroplast DNA from ozone-treated plants. (1989) (38)
- The effect of peroxides and free radicals on body tissues. (1997) (38)
- Antioxidants Reduce Cellular and Functional Changes Induced by Intense Noise in the Inner Ear and Cochlear Nucleus (2014) (37)
- Determination of Biological Oxidative Stress Using High Performance Liquid Chromatography with Electrochemical Detection (HPLC‐ECD) (1999) (37)
- Effects of Antioxidant Treatment on Blast-Induced Brain Injury (2013) (37)
- Age effect on brain pH during ischemia/reperfusion and pH influence on peroxidation (1994) (37)
- Copper, zinc superoxide dismutase enhances DNA damage and mutagenicity induced by cysteine/iron. (2000) (37)
- Evidence for vitamin K semiquinone as the functional form of vitamin K in the liver vitamin K-dependent protein carboxylation reaction. (1976) (36)
- Preferential targeting of oxidative base damage to internucleosomal DNA. (1996) (36)
- Mitochondrial dysfunction in choline deficiency-induced apoptosis in cultured rat hepatocytes. (2005) (36)
- Generation of strand breaks and formation of 8-hydroxy-2'-deoxyguanosine in DNA by a Thiol/Fe3+/O2-catalyzed oxidation system. (1994) (35)
- Evidence for enhanced neuro-inflammatory processes in neurodegenerative diseases and the action of nitrones as potential therapeutics. (2000) (35)
- Time course of tissue water proton spin-lattice relaxation in mice developing ascites tumors. (1974) (35)
- Multiparametric assessment of the anti‐glioma properties of OKN007 by magnetic resonance imaging (2010) (35)
- Nitrone-Related Therapeutics (2004) (34)
- Cytotoxic effects of autoxidative glycation. (1995) (34)
- Basal protein phosphorylation is decreased and phosphatase activity increased by an antioxidant and a free radical trap in primary rat glia. (1999) (34)
- Regression of glioma tumor growth in F98 and U87 rat glioma models by the Nitrone OKN-007. (2013) (34)
- Specific repression of β-globin promoter activity by nuclear ferritin (2001) (33)
- [27] High-pressure liquid chromatography-electrochemical detection of oxygen free radicals (1984) (32)
- Mechanism of chromium(VI) carcinogenesis (1989) (32)
- Inhibition of the cytokine-mediated inducible nitric oxide synthase expression in rat insulinoma cells by phenyl N-tert-butylnitrone. (2000) (32)
- Anoxic injury of endothelial cells increases production of nitric oxide and hydroxyl radicals. (1996) (31)
- Inactivation of glutathione peroxidase by benzaldehyde. (1996) (30)
- Clearance of Continuously Infused 5-Fluorouracil in Adults Having Lung or Gastrointestinal Carcinoma with or without Hepatic Metastases (1982) (30)
- Nitric oxide and derived species as toxic agents in stroke, AIDS dementia, and chronic neurodegenerative disorders. (1997) (30)
- Obligatory free radical intermediate in the oxidative activation of the carcinogen N-hydroxy-2-acetylaminofluorene. (1977) (30)
- Spin trapping agent phenyl N‐tert‐butylnitrone protects against the onset of drug‐induced insulin‐dependent diabetes mellitus (1997) (29)
- Characterization of hydroxyl free radical mediated damage to plasmid pBR322 DNA. (1989) (29)
- Prevention of reoxygenation injury by sodium salicylate in isolated-perfused rat liver. (1998) (29)
- In vivo trapping of nitric oxide in the brain of neonatal rats treated with the HIV-1 envelope protein gp 120: protective effects of alpha-phenyl-tert-butylnitrone. (1996) (28)
- Phase I and pharmacologic study of 72‐hour infused 5‐fluorouracil in man (1985) (28)
- In vivo MRS assessment of altered fatty acyl unsaturation in liver tumor formation of a TGF alpha/c-myc transgenic mouse model. (2009) (28)
- Thiol-dependent metal-catalyzed oxidation of copper, zinc superoxide dismutase. (1998) (28)
- Induction of Akt phosphorylation in rat primary astrocytes by H2O2 occurs upstream of phosphatidylinositol 3-kinase: no evidence for oxidative inhibition of PTEN. (2001) (28)
- Effects of delayed and extended antioxidant treatment on acute acoustic trauma (2011) (27)
- Ameliorative Effects of Antioxidants on the Hippocampal Accumulation of Pathologic Tau in a Rat Model of Blast-Induced Traumatic Brain Injury (2015) (27)
- Selective degeneration of synapses in the dorsal cochlear nucleus of chinchilla following acoustic trauma and effects of antioxidant treatment (2012) (27)
- Iron-induced lipid peroxidation and inhibition of dopamine synthesis in striatum synaptosomes (1989) (27)
- Increased in vitro lipid peroxidation of gerbil cerebral cortex as compared with rat (1986) (27)
- Gel formation on nodal root surfaces ofZea mays (1970) (26)
- Measurement of oxidative stress in vivo (1993) (26)
- Changes of tissue water proton relaxation rates during early phases of chemical carcinogenesis. (1975) (25)
- Serendipitous findings while researching oxygen free radicals. (2009) (25)
- Peroxidation induced changes in synaptosomal transport of dopamine and gamma-aminobutyric acid. (1989) (25)
- Effects of phenyl N‐tert‐butyl nitrone and its derivatives on the early phase of hepatocarcinogenesis in rats fed a choline‐deficient, L‐amino acid‐defined diet (2003) (25)
- Fluorometric and Colorimetric Assessment of Thiobarbituric Acid-Reactive Lipid Aldehydes in Biological Matrices (2003) (25)
- Antioxidants reduce neurodegeneration and accumulation of pathologic Tau proteins in the auditory system after blast exposure (2017) (25)
- Methods in biological oxidative stress (2003) (25)
- Erratum to: Antioxidants Reduce Cellular and Functional Changes Induced by Intense Noise in the Inner Ear and Cochlear Nucleus (2014) (24)
- Influence of calcium on sodium and potassium absorption by fresh and aged bean stem slices. (1970) (24)
- Visualization of the protective ability of a free radical trapping compound against rat C6 and F98 gliomas with diffusion tensor fiber tractography (2008) (23)
- Effects of PBN and OKN007 in rodent glioma models assessed by 1H MR spectroscopy. (2011) (23)
- ESR spin trapping studies on the OH* free radical reactions of idebenone. (1990) (23)
- Sensitivity of protein tyrosine phosphatase activity to the redox environment, cytochrome C, and microperoxidase. (2005) (23)
- Free radicals in arylamine carcinogenesis. (1981) (22)
- INTESTINAL ISCHEMIA: REPERFUSION‐MEDIATED INCREASE IN HYDROXYL FREE RADICAL FORMATION AS REPORTED BY SALICYLATE HYDROXYLATION (1994) (22)
- Inhibition of the development of hepatocellular carcinomas by phenyl N-tert-butyl nitrone in rats fed with a choline-deficient, L-amino acid-defined diet. (2004) (22)
- Nitric Oxide and Cancer Development (2007) (21)
- Phenyl-N-tert-butylnitrone demonstrates broad-spectrum inhibition of apoptosis-associated gene expression in endotoxin-treated rats. (1999) (21)
- Therapeutic effects of orally administrated antioxidant drugs on acute noise-induced hearing loss (2014) (19)
- DNA cytosine methylation profile in various cancer-related genes is altered in cultured rat hepatocyte cell lines as compared with primary hepatocytes. (2006) (18)
- CPI-1189 inhibits interleukin 1β-induced p38-mitogen-activated protein kinase phosphorylation: an explanation for its neuroprotective properties? (2000) (18)
- Observations on nitroxyl free radicals in arylamine carcinogenesis and on spin-trapping hydroxyl free radicals (1982) (18)
- Modulation of Fas-FasL related apoptosis by PBN in the early phases of choline deficient diet-mediated hepatocarcinogenesis in rats (2007) (18)
- Studies on the effect of iron overload on rat cortex synaptosomal membranes. (1985) (17)
- Nitrone radical traps protect in experimental neurodegenerative diseases (1996) (17)
- Reactive oxygen species in choline deficiency-induced apoptosis in rat hepatocytes. (2004) (17)
- Anti-cancer activity of nitrones in the ApcMin/+ model of colorectal cancer (2010) (16)
- Bleomycin-iron damage to DNA with formation of 8-hydroxydeoxyguanosine and base propenals. Indications that xanthine oxidase generates superoxide from DNA degradation products. (1990) (16)
- Glutamate accumulation and increased hydroxyl free radical formation in the abdominal aorta and heart of gerbil after ischemia/reperfusion insult. (1992) (15)
- Improved liquid chromatographic assay for serum fluorouracil concentrations in the presence of ftorafur. (1981) (15)
- Oxygen radical-mediated damage to brain tissue. (1988) (15)
- Direct Administration of Interleukin-1 and Interferon-&ggr; to Rat Pancreas Leads to the In Vivo Production of Nitric Oxide and Expression of Inducible Nitric Oxide Synthase and Inducible Cyclooxygenase (2001) (14)
- Reactive Oxygen Involvement in Neurodegenerative Pathways (1998) (13)
- Gene Expression and Functional Changes After Acute Ischemia: Age-Related Differences in Outcome and Mechanisms (1994) (13)
- ESR SIGNALS DURING X‐IRRADIATION OF TISSUE: THEIR CHARACTERISTICS AND RELATIONSHIP TO THE CANCEROUS STATE * (1973) (13)
- Distinct patterns of gene expression in hepatocellular carcinomas and adjacent non‐cancerous, cirrhotic liver tissues in rats fed a choline‐deficient, l‐amino acid‐defined diet (2005) (13)
- Mutagenicity of free-radical spin-trapping compounds. (1981) (13)
- Hematoporphyrin D plus light mediates 8-hydroxyguanine formation in DNA and RNA (1990) (13)
- Formation of reactive oxygen species and of 8-hydroxy-2'-deoxyguanosine in DNA in vitro with betel-quid ingredients. (1988) (13)
- Evaluation of nitrone spin-trapping agents as radioprotectors. (1996) (13)
- Microsome catalyzed conversion of N-hydroxy-N-acetyl-2-aminofluorene by cumene-hydroperoxide. (1976) (12)
- Free-radical events in chemical and biochemical reactions involving carcinogenic arylamines. (1981) (12)
- Qβ Bacteriophage Photoinactivated by Methylene Blue Plus Light Involves Inactivation of Its Genomic RNA (1999) (12)
- Anoxic injury of endothelial cells causes divergent changes in protein kinase C and protein kinase A signaling pathways. (1998) (11)
- Studies of the fatty acid composition and membrane microviscosity in Salmonella typhimurium TA98. (1980) (11)
- Hydralazine-dependent carbon dioxide free radical formation by metabolizing mitochondria. (1988) (10)
- Cerebrospinal fluid versus serum concentrations of 5-FU, allopurinol, and oxypurinol during treatment of metastatic brain cancer with 5-FU infusion, allopurinol, and radiation. (1982) (10)
- Nitric oxide production by primary liver cells isolated from amino acid diet-fed rats. (2005) (10)
- Glutathione/Fe3+/O2-mediated DNA strand breaks and 8-hydroxydeoxyguanosine formation. Enhancement by copper, zinc superoxide dismutase. (1997) (9)
- Erythrosine B (red dye No. 3) mediated oxidation-reduction in brain membranes. (1980) (9)
- The development of a sensitive analysis for 8-hydroxy-2'-deoxyguanosine. (1990) (9)
- Soil Contamination of Field-Grown Corn Plants 1 (1966) (8)
- The effects of the molecular environment on the kinetics of catalase reaction and its relevance to cell aging. (1991) (8)
- Studies on the Mutagenicity and Electron Spin Resonance Spectra of Nitrosofluorene-Lipid Adducts (1980) (8)
- Production of Free Radicals (1997) (8)
- The Protective Action of Nitrone-Based Free Radical Traps in Neurodegenerative Diseases (1996) (8)
- HPN-07, a free radical spin trapping agent, protects against functional, cellular and electrophysiological changes in the cochlea induced by acute acoustic trauma (2017) (8)
- Chemical versus Pharmacological Actions of Nutraceutical Phytochemicals: Antioxidant and Anti Inflammatory Modalities (2004) (8)
- Gel formation on nodal root surfaces ofZea mays. Some observations relevant to understanding its action at the root-soil interface (1971) (8)
- Phase I and pharmacologic study of oral ftorafur and X ray therapy in advanced gastrointestinal cancer. (1985) (7)
- An electron paramagnetic resonance study of the reaction of nitrosobenzene with cholesterol (1982) (7)
- PBN (Phenyl-N-Tert-Butylnitrone)-Derivatives Are Effective in Slowing the Visual Cycle and Rhodopsin Regeneration and in Protecting the Retina from Light-Induced Damage (2015) (7)
- Binding and mutagenicity studies with 2-nitrosofluorene on Salmonella typhimurium TA98 grown at different temperatures. (1980) (7)
- Oxidative modification of proteins in cell signaling. (2005) (7)
- INVOLVEMENT OF ACTIVATED OXYGEN SPECIES IN MEMBRANE PEROXIDATION: POSSIBLE MECHANISMS AND BIOLOGICAL CONSEQUENCES (1984) (7)
- 8-Hydroxydeoxyguanosine in DNA from TPA-stimulated human granulocytes. (1994) (7)
- Membrane structure and function. I. An electron microscope study of the alteration induced by laser irradiation on the chloroplast lamellar membranes. (1971) (6)
- Investigation of respiratory and ion transport properties of aging bean stem slices. (1971) (5)
- Protease inhibition of natural killer (NK) and antibody-dependent cell-mediated cytoxicity (ADCC) activities. (1984) (5)
- Activation of the carcinogen N-hydroxy-2-acetylaminofluorene by rat mammary peroxidase (1978) (5)
- Reactive Oxygen Involvement in Neurodegenerative Pathways: Causes, Consequences, and Potential Management with Nitrone-Based Free Radical Traps (1997) (5)
- The Arachidonic Acid 5-Lipoxygenase Inhibitor Nordihydroguaiaretic Acid Inhibits TNFá Activation of Microglia and Extends Survival of G93A-SOD1 Transgenic Mice (2004) (5)
- Fluorogenic Analysis of H 2 O 2 in Biological Materials (2003) (4)
- Serum concentrations of 5-FU, ftorafur, and a major serum metabolite following ftorafur chemotherapy. (1981) (4)
- Antioxidants, Oxidative Stress, and Degenerative Neurological Disorders (44448) (1999) (4)
- The deacetylation of N-hydroxy-2-acetylaminofluorene by rat liver microsomes and carboxyl esterase. (1980) (4)
- High-pressure liquid chromatography--electrochemical detection of oxygen free radicals. (1984) (4)
- Photochemical synthesis of 8-hydroxyguanine nucleosides. (1994) (4)
- DNA DAMAGE AND REPAIR (1991) (4)
- Membrane structure and function. II. Alterations in the photo-induced absorption changes after treatment of isolated chloroplasts with large pulses of the ruby laser. (1971) (4)
- 3-(3,4-Dichlorophenyl)-1,1-dimethylurea Effect on Cytochrome b(559) Photooxidation and Q Reduction at Temperatures Near 0 C. (1972) (3)
- HPLC With Electrochemical and Photodiode Array Detection Analysis of Tocopherol Oxidation and Nitration Products in Human Plasma (2003) (3)
- Breeding resistance in eucalypts to insect attack (1997) (3)
- Murine lymphoma alkaline phosphatase: a cell membrane carcinofetal enzyme. (1979) (3)
- Biological role of vitamin K at the molecular level. (1978) (3)
- Effect of Aging on Pancreatic Lipolytic Enzymes (1986) (3)
- Methods in Molecular Biology, Volume 108, Free Radical and Antioxidant Protocols. Edited by Donald Armstrong. Humana Press, Totowa, New Jersey, 1998. 455 pp. (1999) (3)
- Conditions influencing the 8-hydroxyguanine content of microsomal RNA and mitochondrial and nuclear DNA and RNA (1990) (2)
- Bioassay of 2′-Deoxyguanosine/8-Hydroxy-2′-Deoxyguanosine by HPLC With Electrochemical/Photodiode Array Detection (2003) (2)
- In Vivo Detection of Oxygen Free Radical Species (1993) (2)
- Free radical activation of N-hydroxy-2-acetylaminofluorene by methemoglobin and hydrogen peroxide. (1979) (2)
- A new technique of depositing phospholipid bilayers on quartz surfaces: its use in membrane spin-label studies. (1981) (2)
- Brain antioxidant activity of spin traps in Mongolian gerbils. (1994) (2)
- Lipid HydroperoxideActivationof N-Hydroxy-N acetylaminofluorenevia a Free Radical Route1 (1976) (2)
- Free radicals produced in a nitrosofluorene-unsaturated lipid reaction (1977) (2)
- Mechanistic Studies On the Anti-Cancer Activity of 2,4-disulfonyl-PBN (OKN-007) (2011) (1)
- EEG Spectra following Phenytoin Infusion in Seizure Patients (1984) (1)
- Nitrones as Potent Anticancer Therapeutics (2016) (1)
- Edx-17: A Novel, Safe and Efficacious Treatment for Sickle Cell Disease (2014) (1)
- Pretreatment with spin-trapping compounds reduces ischemic damage to rat intestine (1990) (1)
- Hydroxyl Free Radical Mediated Strand Breaks in PBR322 Plasmid DNA (1987) (1)
- antiviral therapy using thiazine based dyes and xanthene. (1990) (1)
- The natural killer cell. (1979) (1)
- Placental Alkaline Phosphatase Appearance in Murine Lymphomas (1978) (1)
- Neuroinflammation-Mediated Neurotoxin Production in Neurodegenerative Diseases (2003) (1)
- A composition for in vivo treatment gives \ os tissues produced by ischemia or other dysfunction from oxidation. (1990) (0)
- Acknowledgement to Reviewers (1994) (0)
- Methods and compositions for the inhibition of diseases associated with oxidative damage diseases. (1990) (0)
- Abstract 675: Effects of PBN and OKN007 in rodent glioma models assessed by 1H MR spectroscopy (2011) (0)
- 1 PBN ( α-phenyl-N-tert-butyl nitrone ) Prevents Light-induced Degeneration of the Retina by Inhibiting RPE 65 Isomerohydrolase Activity (2011) (0)
- Influence of dietary restriction on immunologic function of nzb x nzw f1 (b/w) mice. Abstr. (1978) (0)
- Hydroxyl radical detection in vivo (1986) (0)
- Tumor regression and angiogenesis inhibition by phenyl-tert-butyl nitrone and its main metabolite in C6 rat glioma model (2007) (0)
- Phenyl Butyl Nitrone Compositions and Methods for Treatment of Oxidative Tissue Damage (2017) (0)
- Changes of Tissue Water Proton Relaxati of Chemical Carcinogenesis (2016) (0)
- Method and compositions for the inhibition of diseases associated with oxidative tissue damage alterations. (1990) (0)
- Protection Against Oxygen Toxicity By Intravenous Injec tion Of Liposome-Entrapped Catalase And Superoxide Dis mutase (2017) (0)
- The Nitrone 2,4disulfonyl-PBN Inhibits the Enzymatic Activity of the Extracellular Sulfatase Endosulfatase2 (Sulf2) and has Anticancer Activity in a Xenograph Breast Cancer Model (2010) (0)
- Proton Nuclear Magnetic Resonance Studies of Porcine Intestinal Calcium Binding Protein (1983) (0)
- Topically Administered PBN and Methyl-PBN inhibits the visual cycle and slows rhodopsin regeneration in mice and baboon eyes. (2015) (0)
- Involvement of iNOS and HIF-1α in the anti-cancer activity of α-phenyl-N-tert-butyl nitrone (PBN) in liver tumor cells (2007) (0)
- Spin Trapping Pharmaceutical Compositions and Methods for Use Thereof (2017) (0)
- Use of long-term liver organotypic cultures (LT-LOC) to study a new hypothesis on the mechanism of choline deficiency-induced hepatocarcinogenesis in rats (2005) (0)
- Daily administration of α-phneyl-N-tert-butyl nitrone (PBN) decreases the level of oxidized brain protein and increases brain glutamine synthetase activity in aged gerbils (1990) (0)
- PBN Protection Of Retina From Light-damage Is Through Inhibition Of Rpe65 Isomerohydrolase Activity (2011) (0)
- Quantitation of Free Radical Formation in vivo and Serendipitous Discovery of the Neuroprotective Activity of PBN (1999) (0)
- INTERNATIONAL PATENT APPLICATION for ADJUVANT CHEMOTHERAPY FOR ANAPLASTIC GLIOMAS by Rheal (2007) (0)
- 2,4-disulfonyl phenyl nitrone tert-butyl for treating gliomas (2009) (0)
- Ferritin Heavy Chain Stimulates HbS-to-HbF Switching in Erythroid Precursor Cells from Sickle Cell Patients. (2006) (0)
- Abstract #5493: Antitumor effects by novel nitrone compound OKN007 in a rat C6 glioma model (2009) (0)
- HPLC With Electrochemical Detection Analysis of 3-Nitrotyrosine in Human Plasma (2003) (0)
- Evaluation of Extracellular Endosulfatase HSULF-2 in Breast Cancer Cell WNT Signaling and Its Inhibition by a Sulfate Ester Derivative of Synthetic Antioxidant (2010) (0)
- Abstract 2267: Inhibition of extracellular sulfatase 2 as a possible mechanism to partially explain the anticancer activity of the nitrone OKN007 (2010) (0)
- Nitrone compounds to treat sensorineural hearing loss (2010) (0)
- MRI and MRS of intracerebral C6 and 9L/lacZ rat gliomas: Assessment of glioma models and antioxidant treatment (2005) (0)
- A comparison of the ontogeny of the natural and anti- body-dependent cell-mediated cytotoxicity in aging mice. Abstr. (1979) (0)
- PSS279 - EdX-17, a Novel Treatment for Sickle Cell Disease (2013) (0)
- Visualization of protection ability by phenyl-NT-butyl nitrone (PBN) against glioma in rats by diffusion tensor magnetic resonance imaging (2006) (0)
- Modulation of natural killer activity by lymphoid cells in young and old sublethally irradiated mice (1980) (0)
- Methods for the treatment of acute acoustic trauma (2007) (0)
- Abstract 556: Extracellular sulfatase 2; enzymatic inhibition by OKN-007 a disulfonylphenyl nitrone with anticancer activity and other sulfamate and sulfone compounds (2011) (0)
- Method and Compositions for Treating Age Related Disorders (2017) (0)
- Gene regulation with ferritin (2001) (0)
- Production of medicinal composition using thiazine dye or xanthene dye (1995) (0)
- Neuroinflammation-Mediated Neurotoxin Production in Neurodegenerative Diseases: Potential of Nitrones as Therapeutics (2002) (0)
- Abstract 2831: Studies on the mechanistic basis of the anticancer activity of 2,4-disulfonyl-PBN (OKN-007) (2012) (0)
- Expression of apoptosis and proto-oncogene related proteins with hepatocarcinogenesis from choline-deficient diet rats in early phase. (2007) (0)
- Long-Term Effects of DMPO on Switching Macrophage’s Phenotype in the Obese Adiopose Tissue (2016) (0)
- 5-nitro-gamma-tocopherol is a biomarker for nitrative stress in human neurological disease (2000) (0)
- Excessbrainprotein oxidation andenzymedysfunction innormal agingandinAlzheimer disease (1991) (0)
- Modulation of nk activity by lymphoid cells in young and old sublethally irradiated mice. Abstr. (1980) (0)
- Nitrone anti-cancer activity in Apcmin/+ model of colon cancer (2008) (0)
- A developmental switch yields a treatment for beta thalassemias and sickle cell disease (2010) (0)
- Mechanism of Short Term Anti-Inflammatory Effect of 5,5-Dimethyl-1-Pyrroline N-Oxide (2016) (0)
- Inhibition by phenyl N-tert-butyl nitrone of early phase hepato-carcinogenesis in rats fed a choline-deficient diet (1998) (0)
- Abstract 3574: Study of the anti-glioma properties of the nitrone OKN007 by magnetic resonance imaging (2010) (0)
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