Ralph A. Giannella
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Ralph A. Giannellabiology Degrees
Biology
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Microbiology
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#920
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Molecular Biology
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#2323
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Biochemistry
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#2515
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Biology
Ralph A. Giannella's Degrees
- PhD Microbiology University of California, Berkeley
- Masters Biology Stanford University
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(Suggest an Edit or Addition)Ralph A. Giannella's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Attaching and effacing activities of rabbit and human enteropathogenic Escherichia coli in pig and rabbit intestines (1983) (869)
- Gastric acid barrier to ingested microorganisms in man: studies in vivo and in vitro (1972) (406)
- Mice Lacking the Basolateral Na-K-2Cl Cotransporter Have Impaired Epithelial Chloride Secretion and Are Profoundly Deaf* (1999) (396)
- Suckling mouse model for detection of heat-stable Escherichia coli enterotoxin: characteristics of the model (1976) (377)
- A clinicopathologic study of enterocyte-adherent Escherichia coli: a cause of protracted diarrhea in infants. (1982) (347)
- Influence of gastric acidity on bacterial and parasitic enteric infections. A perspective. (1973) (303)
- Pathogenesis of salmonellosis. Studies of fluid secretion, mucosal invasion, and morphologic reaction in the rabbit ileum. (1973) (192)
- Invasion of HeLa cells by Salmonella typhimurium: a model for study of invasiveness of Salmonella. (1973) (181)
- Pathophysiology of Shigella diarrhea in the rhesus monkey: intestinal transport, morphological, and bacteriological studies. (1974) (167)
- Mechanisms of infectious diarrhea (2008) (165)
- Randomized, Double-Blind, Placebo-Controlled, Multicentered Trial of the Efficacy of a Single Dose of Live Oral Cholera Vaccine CVD 103-HgR in Preventing Cholera following Challenge with Vibrio cholerae O1 El Tor Inaba Three Months after Vaccination (1999) (164)
- Purification and characterization of heat-stable enterotoxin produced by a strain of E. coli pathogenic for man. (1980) (157)
- Usefulness of colonoscopy with biopsy in the evaluation of patients with chronic diarrhea (2001) (145)
- Mice lacking the guanylyl cyclase C receptor are resistant to STa-induced intestinal secretion. (1997) (124)
- Small intestinal mucosal injury in the experimental blind loop syndrome. Light- and electron-microscopic and histochemical studies. (1975) (123)
- Indomethacin inhibition of Salmonella typhimurium, Shigella flexneri, and cholera-mediated rabbit ileal secretion. (1974) (118)
- Pathogenesis of Salmonella-mediated intestinal fluid secretion. Activation of adenylate cyclase and inhibition by indomethacin. (1975) (113)
- Jejunal brush border injury and impaired sugar and amino acid uptake in the blind loop syndrome. (1974) (110)
- Mechanism of action of Escherichia coli heat stable enterotoxin in a human colonic cell line. (1988) (108)
- Age-related differences in receptors for Escherichia coli heat-stable enterotoxin in the small and large intestine of children. (1988) (103)
- Importance of the intestinal inflammatory reaction in salmonella-mediated intestinal secretion (1979) (102)
- Pathogenesis of acute bacterial diarrheal disorders. (1981) (102)
- Acute diarrhea: a practical review (1999) (101)
- Randomized, Controlled Human Challenge Study of the Safety, Immunogenicity, and Protective Efficacy of a Single Dose of Peru-15, a Live Attenuated Oral Cholera Vaccine (2002) (97)
- Guanylin and uroguanylin induce natriuresis in mice lacking guanylyl cyclase-C receptor. (2004) (96)
- Effect of Purified Escherichia coli Heat-Stable Enterotoxin on Intestinal Cyclic Nucleotide Metabolism and Fluid Secretion (1979) (93)
- Amino acid sequence of heat-stable enterotoxin produced by Escherichia coli pathogenic for man. (1981) (93)
- The Immature Rat Small Intestine Exhibits an Increased Sensitivity and Response to Escherichia coli Heat-Stable Enterotoxin (1986) (80)
- Binding of Escherichia coli heat-stable enterotoxin to receptors on rat intestinal cells. (1983) (75)
- Validation of a Volunteer Model of Cholera with Frozen Bacteria as the Challenge (1998) (70)
- Development of a radioimmunoassay for Escherichia coli heat-stable enterotoxin: comparison with the suckling mouse bioassay (1981) (69)
- Vitamin B12 uptake by intestinal microorganisms: mechanism and relevance to syndromes of intestinal bacterial overgrowth. (1971) (68)
- Th17 cells: interactions with predisposing factors in the immunopathogenesis of inflammatory bowel disease (2012) (65)
- Escherichia coli heat-stable enterotoxins, guanylins, and their receptors: what are they and what do they do? (1995) (65)
- The guanylin/STa receptor is expressed in crypts and apical epithelium throughout the mouse intestine. (1996) (65)
- Gastro 2013 APDW/WCOG Shanghai Working Party Report: Chronic diarrhea: Definition, classification, diagnosis (2014) (64)
- Renal effects of uroguanylin and guanylin in vivo. (1999) (63)
- Revised amino acid sequence for a heat-stable enterotoxin produced by an Escherichia coli strain (18D) that is pathogenic for humans (1985) (62)
- T84 cell receptor binding and guanyl cyclase activation by Escherichia coli heat-stable toxin. (1987) (60)
- Pathophysiology of Salmonella diarrhea in the Rhesus monkey: Intestinal transport, morphological and bacteriological studies. (1974) (59)
- Citrobacter freundii produces an 18-amino-acid heat-stable enterotoxin identical to the 18-amino-acid Escherichia coli heat-stable enterotoxin (ST Ia) (1989) (59)
- Simple and reliable enzyme-linked immunosorbent assay with monoclonal antibodies for detection of Escherichia coli heat-stable enterotoxins (1984) (57)
- Infectious colitis (2011) (56)
- Competition between bacteria and intrinsic factor for vitamin B 12 : implications for vitamin B 12 malabsorption in intestinal bacterial overgrowth. (1972) (52)
- E. coli heat-stable enterotoxin and guanylyl cyclase C: new functions and unsuspected actions. (2003) (49)
- Na+-K+)-stimulated adenosinetriphosphatase in isolated intestinal villus tip and crypt cells. (1974) (49)
- Novel sites for expression of an Escherichia coli heat-stable enterotoxin receptor in the developing rat. (1992) (49)
- Small and Large Intestinal Guanylate Cyclase Activity in Children: Effect of Age and Stimulation by Escherichia coli Heat-Stable Enterotoxin (1987) (48)
- Effects of olestra and sorbitol consumption on objective measures of diarrhea: impact of stool viscosity on common gastrointestinal symptoms. (2000) (46)
- Comparison of the biological actions of three purified heat-stable enterotoxins: effects on ion transport and guanylate cyclase activity in rabbit ileum in vitro (1981) (46)
- A gradient in expression of the Escherichia coli heat-stable enterotoxin receptor exists along the villus-to-crypt axis of rat small intestine. (1992) (46)
- Comparison of receptors for Escherichia coli heat-stable enterotoxin: novel receptor present in IEC-6 cells. (1993) (46)
- Effect of indomethacin on intestinal water transport in salmonella-infected rhesus monkeys (1977) (43)
- Hemorrhagic colitis associated with Escherichia coli O157:H7. (1992) (41)
- Biological and immunological characteristics of 125I-4Tyr and -18Tyr Escherichia coli heat-stable enterotoxin species purified by high-performance liquid chromatography. (1985) (39)
- Diabetic ketoacidosis with clozapine treatment. (1999) (39)
- Fluid and electrolyte transport in rhesus monkeys challenged intracecally with Shigella flexneri 2a (1976) (36)
- Thinking beyond the colon-small bowel Involvement in clostridium difficile infection (2009) (35)
- Escherichia coli peritonitis after left-sided colonoscopy in a patient on continuous ambulatory peritoneal dialysis. (1987) (33)
- A hospital food-borne outbreak of diarrhea caused by Bacillus cereus: clinical, epidemiologic, and microbiologic studies. (1979) (33)
- Escherichia coli enterotoxin (STa) binds to receptors, stimulates guanyl cyclase, and impairs absorption in rat colon. (1992) (32)
- Effect of E. coli heat-stable enterotoxin on colonic transport in guanylyl cyclase C receptor-deficient mice. (2001) (32)
- Heat‐stable enterotoxin of Escherichia coli (STa) can stimulate duodenal HCO3− secretion via a novel GC‐C‐ and CFTR‐independent pathway (2008) (32)
- Production of neutralizing monoclonal antibodies to Escherichia coli heat-stable enterotoxin (1985) (29)
- Escherichia coli heat-stable toxin: its effect on motility of the small intestine. (1982) (27)
- Validation and Characterization of a Human Volunteer Challenge Model for Cholera by Using Frozen Bacteria of the New Vibrio cholerae Epidemic Serotype, O139 (1999) (26)
- Activation of intestinal mucosal adenylate cyclase by Shigella dysenteriae I enterotoxin. (1976) (26)
- Gastrointestinal bleeding and iron absorption in the experimental blind loop syndrome. (1976) (23)
- Hepatocyte nuclear factor-4 regulates intestinal expression of the guanylin/heat-stable toxin receptor. (1999) (22)
- Immunization of swine with heat-stable Escherichia coli enterotoxin coupled to a carrier protein does not protect suckling pigs against an Escherichia coli strain that produces heat-stable enterotoxin (1983) (22)
- Na(+)-K(+)-ATPase gene expression in rat intestine and Caco-2 cells: response to thyroid hormone. (1993) (22)
- Effect of short-chain fatty acids on cyclic 3',5'-guanosine monophosphate-mediated colonic secretion. (1999) (22)
- Different crosslinking agents identify distinctly different putative Escherichia coli heat-stable enterotoxin rat intestinal cell receptor proteins. (1990) (22)
- Clinical application of polymerase chain reaction to diagnose Clostridium difficile in hospitalized patients with diarrhea. (2004) (21)
- Increases in guanylin and uroguanylin in a mouse model of osmotic diarrhea are guanylate cyclase C-independent. (2001) (21)
- A role for guanylate cyclase C in acid-stimulated duodenal mucosal bicarbonate secretion. (2004) (20)
- The role of altered intestinal permeability in the pathogenesis of salmonella diarrhea in the rhesus monkey. (1976) (20)
- Infectious Enteritis and Proctocolitis and Bacterial Food Poisoning (2010) (19)
- Mechanisms of Shigella pathogenesis. (1972) (19)
- Approach to the adult patient with acute diarrhea. (1993) (19)
- Differences in jejunal and ileal response to E. coli enterotoxin: possible mechanisms. (1989) (17)
- Folic acid abnormalities in iron deficiency: the mechanism of decreased serum folate levels in rats. (1974) (16)
- Guanylin and E. coli Heat-Stable Enterotoxin Induce Chloride Secretion through Direct Interaction with Basolateral Compartment of Rat and Human Colonic Cells (2005) (16)
- Effect of clindamycin on intestinal water and glucose transport in the rat. (1981) (16)
- Blinded, two-laboratory comparative analysis of Escherichia coli heat-stable enterotoxin production by using monoclonal antibody enzyme-linked immunosorbent assay, radioimmunoassay, suckling mouse assay, and gene probes (1986) (16)
- Activation of guanylate cyclase by E. coli heat‐stable enterotoxin (STa) (1986) (14)
- Antibiotic therapy for bacterial enterocolitis: a comprehensive review. (1993) (14)
- Chronic diarrhea in travelers: diagnostic and therapeutic considerations. (1986) (13)
- Association and dissociation of Escherichia coli heat-stable enterotoxin from rat brush border membrane receptors (1987) (13)
- Colonocyte basolateral membranes contain Escherichia coli heat-stable enterotoxin receptors. (2001) (13)
- Role of plasma filtration in the intestinal fluid secretion mediated by infection with Salmonella typhimurium (1976) (12)
- Enteric infections: 50 years of progress. (1993) (12)
- Localization of the guanylyl cyclase C gene to mouse chromosome 6 and human chromosome 12p12. (1996) (12)
- Na+-K+-Activated Adenosine Triphosphatase (1975) (11)
- Use of omeprazole in the management of giant duodenal ulcer: results of a prospective study. (1999) (11)
- Protein kinase C regulates transcription of the human guanylate cyclase C gene. (2001) (11)
- Studies on the pathogenesis of enteric infections caused by invasive bacteria. (2008) (10)
- Jejunal toxin inactivation regulates susceptibility of the immature rat to STa. (1992) (10)
- Definition, Epidemiology, Pathophysiology, Clinical Classification, and Differential Diagnosis of Diarrhea (2010) (9)
- Antibiotic-associated diarrhea and Clostridium difficile colitis: an update. (2001) (7)
- Reports of diarrhea: When is stool water output clinically meaningful? A randomized, controlled trial of olestra and sorbitol (1998) (7)
- Awareness about clostridium difficile infection among internal medicine residents in the United States. (2011) (7)
- Hepatocyte nuclear factor-4 regulates intestinal expression of the guanylin/heat-stable toxin receptor. (1999) (6)
- Diarrhea caused by adherent enteropathogenic E. coli. (1982) (6)
- Misdiagnosis of the Zollinger-Ellison syndrome due to hyperlipidemia. (1990) (5)
- Escherichia coli heat-stable enterotoxin: biochemical and physiological effects on the intestine. (1983) (5)
- Gastric acidity and cholera. (1973) (4)
- Effect of purified E. coli heat-stable enterotoxin (ST) on intestinal transport and possible mechanism of action (1978) (3)
- Acute bacterial diarrhea. (1974) (3)
- Therapy of Digestive Disorders (2006) (3)
- The Levels of IL-17 Secreted by Lipopolysaccharide-Stimulated Eripheral Blood Mononuclear Cells (PBMC) in Inflammatory Bowel Disease (IBD) Patients Significantly Correlated with Disease Severity in Ulcerative Colitis but Not in Crohnʼs Disease: 1275 (2011) (2)
- Cholera-like diarrhoea in salmonellosis. (1973) (2)
- Characteristics of the Binding of Pure Human E. Coli Heat-Stable Enterotoxin to Rat Intestine (1983) (2)
- CHOLERA-LIKE DIARRHŒA IN SALMONELLOSIS (1973) (2)
- Reports of abdominal cramping pain and urgency are correlated with changes in stool viscosity (1998) (1)
- Purification of the heat-stable enterotoxin from E. coli of human origin (1978) (1)
- Helicobacter pylori: an update for primary care physicians. (1995) (1)
- Presentation of the Julius M. Friedenwald Medal to (2005) (1)
- A hypertonic diet increases mouse guanylin and uroguanylin levels via a guanylate cyclase C-independent mechanism (2001) (1)
- AGA PAC: an essential tool to advance gastroenterology. (2008) (1)
- Passing the torch: a look back at our editorship. (1996) (1)
- Approach to the Patient with Suspected Acute Infectious Diarrhea (2009) (1)
- Guanylyl cyclase C deficient mice have more severe carbon tetrachloride (CCl4)-induced liver injury than wild-type controls (2000) (1)
- IDENTIFICATION OF THE HUMAN INTESTINAL RECEPTOR FOR E. COLI HEAT - STABLE ENTEROTOXIN (1990) (1)
- Vitamin B12Uptake byIntestinal Microorganisms: Mechanism andRelevance toSyndromes of Intestinal Bacterial Overgrowth (1971) (1)
- Effect ofStrongyloides ratti on small bowel function in normal and immunosuppressed host rats (1988) (1)
- Lack of guanylate cyclase C (GC-C) leads to reduction of adenoma formation in murine model of intestinal cancer (2001) (1)
- Congenital hepatic fibrosis and cerebral aneurysm in a 32-year-old woman. (1986) (1)
- Task force on training in pediatric gastroenterology (1996) (0)
- Mucosal digestive and absorptive function (1983) (0)
- Chlorpromazine inhibition of enterotoxin-induced intestinal secretion (1979) (0)
- MONOCLONAL ANTIBODIES TO ESCHERICHIA COLI HEAT-STABLE ENTEROTOXIN (1984) (0)
- Human guanylyl cyclase C promoter directs intestinal expression of luciferase reporter gene in transgenic mice (1995) (0)
- THE COLON PLAYS A SIGNIFICANT ROLE IN E.COLI HEAT STABLE ENTEROTOXIN (STa)-MEDIATED DIARRHEAL DISEASE (1990) (0)
- A new intestinal secretory pathway (1979) (0)
- 21. EFFECT OF AGE AND SITE ON BASAL AND E.COLI ST-STIMULATED INTESTINAL GUANYLATE CYCLASE ACTIVITY IN CHILDREN (1987) (0)
- Sixty-ninth annual meeting of the Japanese Society of Gastroenterology (2007) (0)
- Indomethacin-enhanced secretory responses in rabbit ileum (1985) (0)
- Approach to the Patient with Suspected Acute Infectious Diarrhea (2009) (0)
- SIMMETRIC BINDING AND EFFECT ON INTESTINAL TRANSPORT BY THE MUCOSAL OR SEROSAL ADDITION OF E.COLI ST IN RAT COLON (1997) (0)
- Significant Correlation between Interferon-γ (IFN-γ) Secretion by T cells in Peripheral Blood with Disease Severity in Crohnʼs Disease but Not in Ulcerative Colitis: 1564 (2012) (0)
- Figure 21-2, Scheme of the Pathogenesis of Salmonella enterocolitis and diarrhea (1996) (0)
- Pediatric gastroenterology and the AGA. (1999) (0)
- Plasma IL-22 Levels, But Not IL-17, are Significantly Higher in Inflammatory Bowel Disease Patients Compared to the Healthy Adults: 1278 (2011) (0)
- Transcriptional regulation by hepatocyte nuclear factor 4 is critical for intestinal expression of guanylyl cyclase C (1998) (0)
- Painless Jaundice: A Happy Ending: 2831 (2017) (0)
- Mucosal digestive and absorptive function: Binder HJ, Alpers DH, Bayless TM, Gray GM. Produced by the American Gatroenterological Association Undergraduate Teaching Project, unit VI. Fifty-one 35-mm diazo slides with annotations. Milner-Fenwick, Inc., 2125 Greenspring Drive. Timonium, Md. 21093. $76 (1983) (0)
- Observations On Infantile Diarrhea Caused by Enteropathogenic Escherichia Coli (2018) (0)
- The gastric barrier to intestinal infection (1979) (0)
- Preparation of stable 125I cyclic GMP tyrosine methyl ester suitable for 3',5' cyclic GMP radioimmunoassay by HPLC. (1990) (0)
- Schistosomiasis, an Unusual Cause of Variceal Bleeding in the United States (2013) (0)
- Chapter Fifty – Treatment of acute infectious diarrheas (2006) (0)
- Sudden infant death syndrome: A gastrointestinal disease? (1979) (0)
- Faculty Opinions recommendation of Risk of hypertension and reduced kidney function after acute gastroenteritis from bacteria-contaminated drinking water. (2006) (0)
- Diseases of intestinal absorption and secretion. (1975) (0)
- Management of massive upper gastrointestinal bleeding. (1976) (0)
- Studies on Shigellosis and Salmonellosis (1975) (0)
- Sixty-ninth Annual Meeting of the Japanese Society of Gastroenterology (2007) (0)
- Action of E. Coli STa on colonic ion transport in guanylate cyclase c deficient mice (2000) (0)
- Histologic and Bacteriologic Findings in Infants with Enteropathogenic E. Coli Infection (1983) (0)
- 12 HEAT-STABLE ENTEROTOXIN (ST) ENCODED ON TRANSMISSABLE PLASMID (1988) (0)
- [Prophylaxis of superficial tumors of the bladder with interferon alfa-2B]. (1990) (0)
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