Robert Ivan Demars
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Philosophy Biology
Robert Ivan Demars's Degrees
- PhD Immunology University of California, San Francisco
- Doctorate Medicine Stanford University
Why Is Robert Ivan Demars Influential?
(Suggest an Edit or Addition)Robert Ivan Demars's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- A class I antigen, HLA-G, expressed in human trophoblasts. (1990) (1415)
- A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway (1990) (647)
- Human placental HLA-G expression is restricted to differentiated cytotrophoblasts. (1995) (490)
- Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef (1999) (412)
- Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter (1991) (407)
- Detection of a novel human class II HLA antigen (1983) (375)
- Induction of anti-tumor cytotoxic T lymphocytes in normal humans using primary cultures and synthetic peptide epitopes. (1994) (349)
- Presentation of viral antigen by MHC class I molecules is dependent on a putative peptide transporter heterodimer (1992) (342)
- Recognition by human V gamma 9/V delta 2 T cells of a GroEL homolog on Daudi Burkitt's lymphoma cells. (1990) (342)
- Production of human cells expressing individual transferred HLA-A,-B,-C genes using an HLA-A,-B,-C null human cell line. (1989) (328)
- DO beta: a new beta chain gene in HLA‐D with a distinct regulation of expression. (1985) (284)
- Gamma ray-induced loss of expression of HLA and glyoxalase I alleles in lymphoblastoid cells. (1980) (248)
- Transfer and expression of three cloned human non-HLA-A,B,C class I major histocompatibility complex genes in mutant lymphoblastoid cells. (1988) (246)
- HLA-E. A novel HLA class I gene expressed in resting T lymphocytes. (1988) (237)
- Mutant Enzymatic and Cytological Phenotypes in Cultured Human Fibroblasts (1967) (233)
- Characterization of the peptide binding motif of a rhesus MHC class I molecule (Mamu-A*01) that binds an immunodominant CTL epitope from simian immunodeficiency virus. (1998) (232)
- Processing pathways for presentation of cytosolic antigen to MHC class II-restricted T cells (1992) (206)
- Homozygous deletions that simultaneously eliminate expressions of class I and class II antigens of EBV-transformed B-lymphoblastoid cells. I. Reduced proliferative responses of autologous and allogeneic T cells to mutant cells that have decreased expression of class II antigens. (1984) (180)
- Mutations that impair a posttranscriptional step in expression of HLA-A and -B antigens. (1985) (176)
- Resistance of cultured human fibroblasts and other cells to purine and pyrimidine analogues in relation to mutagenesis detection. (1974) (166)
- Somatic cell mutation. Detection and quantification of x-ray-induced mutation in cultured, diploid human fibroblasts. (1973) (162)
- Natural killer susceptibility of human cells may be regulated by genes in the HLA region on chromosome 6. (1986) (141)
- Novel allele-specific, post-translational reduction in HLA class I surface expression in a mutant human B cell line. (1994) (136)
- Demonstration by class I gene transfer that reduced susceptibility of human cells to natural killer cell‐mediated lysis is inversely correlated with HLA class I antigen expression (1989) (133)
- Abnormal ornithine carbamoyltransferase in mice having the sparse-fur mutation. (1976) (125)
- The D1 trisomy syndrome (1963) (109)
- Specificity of monoclonal antibodies directed against human and murine class II histocompatibility antigens as analyzed by binding to HLA-deletion mutant cell lines. (1985) (105)
- Chromosomal organization of the human major histocompatibility complex class I gene family [published erratum appears in J Exp Med 1989 Apr 1;169(4):1517] (1989) (104)
- The D triisomy syndrome and XO gonadal dysgenesis in two sisters. (1961) (104)
- Isolation of HLA locus-specific DNA probes from the 3'-untranslated region. (1984) (100)
- Single-allele expression at an X-linked hyperuricemia locus in heterozygous human cells. (1968) (99)
- Derepression of genes on the human inactive X chromosome: Evidence for differences in locus-specific rates of derepression and rates of transfer of active and inactive genes after DNA-mediated transformation (1982) (99)
- Diploid Azaguanine-Resistant Mutants of Cultured Human Fibroblasts (1970) (92)
- Genetic mapping of a human class II antigen beta-chain cDNA clone to the SB region of the HLA complex. (1983) (89)
- SB: a new HLA-linked human histocompatibility gene defined using HLA-mutant cell lines (1981) (89)
- Serologic identification of the human secondary B cell antigens. Correlations between function, genetics, and structure (1982) (86)
- Induction of HLA class I-restricted CD8+ CTLs specific for the major outer membrane protein of Chlamydia trachomatis in human genital tract infections. (1999) (83)
- Definition of Five New Simian Immunodeficiency Virus Cytotoxic T-Lymphocyte Epitopes and Their Restricting Major Histocompatibility Complex Class I Molecules: Evidence for an Influence on Disease Progression (2000) (81)
- Lateral Gene Transfer In Vitro in the Intracellular Pathogen Chlamydia trachomatis (2006) (80)
- Chlamydia trachomatis major outer membrane protein (MOMP) epitopes that activate HLA class II-restricted T cells from infected humans. (1996) (73)
- Interstrain Gene Transfer in Chlamydia trachomatis In Vitro: Mechanism and Significance (2007) (73)
- Use of HLA loss mutants to analyse the structure of the human major histocompatibility complex (1982) (72)
- Dissection of the D-region of the human major histocompatibility complex by means of induced mutations in a lymphoblastoid cell line. (1983) (72)
- Quantification of chemical mutagenesis in diploid human fibroblasts: induction of azaguanine-resistant mutants by N-methyl-N'-nitro-N-nitrosoguanidine. (1978) (70)
- Localized Derepression on the Human Inactive X Chromosone in Mouse-Human Cell Hybrids. (1975) (68)
- MHC class II deletion mutant expresses normal levels of transgene encoded class II molecules that have abnormal conformation and impaired antigen presentation ability. (1992) (67)
- Lesch-Nyhan Mutation: Prenatal Detection with Amniotic Fluid Cells (1969) (66)
- A minimum of four human class II α-chain genes are encoded in the HLA region of chromosome 6 (1983) (65)
- Molecular localization of human class II MT2 and MT3 determinants (1984) (65)
- Allelic polymorphism and transassociation of molecules encoded by the HLA-DQ subregion. (1985) (65)
- Transfer of cloned human class I major histocompatibility complex genes into HLA mutant human lymphoblastoid cells (1986) (62)
- Epitope clusters in the major outer membrane protein of Chlamydia trachomatis. (2001) (62)
- Molecular analysis of HLA class I and class II antigen loss mutants reveals a homozygous deletion of the DR, DQ, and part of the DP region: implications for class II gene order. (1986) (60)
- Organization of the human class I major histocompatibility complex genes (1987) (58)
- Chemical Mutagenesis in Bacteriophage T2 (1953) (57)
- No evidence for germline mutations in exons 5-9 of the p53 gene in 25 breast cancer families. (1992) (54)
- T-Cell Epitopes in Variable Segments ofChlamydia trachomatis Major Outer Membrane Protein Elicit Serovar-Specific Immune Responses in Infected Humans (2000) (53)
- Class I-like HLA genes map telomeric to the HLA-A2 locus in human cells (1983) (51)
- Detection of females heterozygous for the Lesch-Nyhan mutation by 8-azaguanine-resistant growth of cultured fibroblasts. (1971) (45)
- Construction of a map of the short arm of human chromosome 6. (1986) (44)
- Insulin binding to human B lymphoblasts is a function of HLA haplotype. (1987) (44)
- Expression of human genes for adenine phosphoribosyltransferase and hypoxanthine-guanine phosphoribosyltransferase after genetic transformation of mouse cells with purified human DNA (1980) (43)
- New genes in the MHC that encode proteins for antigen processing. (1992) (42)
- Diaminopurine-resistant mutants of cultured, diploid human fibroblasts. (1973) (41)
- Purine requirement of cells cultured from humans affected with Lesch-Nyhan syndrome (hypoxanthine-guanine phosphoribosyltransferase deficiency). (1969) (40)
- Presentation of cytosolic antigen by HLA-DR requires a function encoded in the class II region of the MHC. (1993) (39)
- A novel HLA-D/DR-like antigen specific for human B lymphoid cells. Biochemical evidence for similarity to but nonidentity with known HLA- D/DR antigens (1983) (36)
- Clonal analysis of the stepwise appearance of anchorage independence and tumorigenicity in CAK, a permanent line of mouse cells. (1982) (34)
- Genetic studies of HG- PRT deficiency and the Lesch-Nyhan syndrome with cultured human cells. (1971) (32)
- The spontaneous azaguanine-resistant mutants of diploid human fibroblasts (2004) (32)
- Specific associations of fluorescent beta-2-microglobulin with cell surfaces. The affinity of different H-2 and HLA antigens for beta-2-microglobulin. (1988) (31)
- Mapping of prolactin and tumor necrosis factor-beta genes on human chromosome 6p using lymphoblastoid cell deletion mutants (1989) (29)
- Simian Immunodeficiency Virus That Binds an Immunodominant CTL Epitope a Rhesus MHC Class I Molecule ( Mamu-A * 01 ) Characterization of the Peptide Binding Motif of (1998) (29)
- Localization of the human MHC-linked complement genes between HLA-B and HLA-DR by using HLA mutant cell lines. (1985) (29)
- DMA and DMB are the only genes in the class II region of the human MHC needed for class II-associated antigen processing. (1995) (28)
- Mosaicism of peripheral blood lymphocyte populations in females heterozygous for the Lesch-Nyhan mutation (1974) (27)
- The locus for human adenine phosphoribosyltransferase on chromosome no. 16. (1974) (26)
- Sequence and gene transfer analyses of HLA-CwBL18 (HLA-C blank) and HLA-Cw5 genes. Implications for the control of expression and immunogenicity of HLA-C antigens. (1989) (25)
- Specific associations of fluorescent β-2-microglobulin with cell surfaces. The affinity of different H-2 and HLA antigens for β-2-microglobulin (1988) (25)
- In vitro chemical mutagenesis and viral transformation of a human endothelial cell strain. (1981) (25)
- Hemizygous HLA mutants of lymphoblastoid cells: a new cell type for histocompatibility testing. (1980) (24)
- The intracellular transport of MHC class II molecules in the absence of HLA-DM. (1995) (24)
- Dissociation in expression of MB1/MT1 and DR1 alloantigens in mutants of a lymphoblastoid cell line. (1983) (23)
- Mutations causing deficiency of APRT in fibroblasts cultured from humans heterozygous for mutantAPRT alleles (1982) (23)
- 14 – CHEMICAL MUTAGENESIS WITH DIPLOID HUMAN FIBROBLASTS (1984) (22)
- Presentation of soluble antigen to human T cells by products of multiple HLA-linked loci: analysis of antigen presentation by a panel of cloned, autologous, HLA-mutant Epstein-Barr virus-transformed lymphoblastoid cell lines. (1987) (21)
- Sex Chromatin Mass in Living, Cultivated Human Cells (1962) (21)
- Human T cell receptor-gamma delta-expressing T-cell lines recognize MHC-controlled elements on autologous EBV-LCL that are not HLA-A, -B, -C, -DR, -DQ, or -DP. (1990) (20)
- Restriction of Epstein-Barr virus-specific cytotoxic T cells by HLA-A, -B, and -C molecules. (1989) (20)
- Autonomous gene expression on the human inactive X chromosome (1980) (18)
- Comparison of multiple HLA-A alleles at the DNA level by using Southern blotting and HLA-A-specific probes. (1985) (17)
- T-Cell Epitopes and Human Leukocyte Antigen Restriction Elements of an Immunodominant Antigen of Blastomyces dermatitidis (2000) (17)
- Follow-up on a human X-autosome translocation first studied in 1963 and 1964. (1978) (15)
- A temperature-sensitive glucose-6-phosphate dehydrogenase in mutant cultured human cells. (1968) (15)
- Gene required for normal MHC class II expression and function is localized to approximately 45 kb of DNA in the class II region of the MHC. (1994) (13)
- The single-active-X: functional differentiation at the chromosome level. (1967) (13)
- Trisomy for chromosome no. 18 in man (2004) (13)
- Isolation and characterization of naturally processed peptides bound by class II molecules and peptides presented by normal and mutant antigen-presenting cells. (1993) (12)
- The D-I trisomy syndrome. (1963) (11)
- Sex Chromatin Patterns and the Lyon Hypothesis (1963) (11)
- The proliferative immune response to autologous Epstein-Barr virus-transformed lymphoblastoid cells. I. Studies with HLA haplotype loss variants demonstrate a role for MHC-linked genes. (1985) (10)
- Localized Derepression on the Human Inactive X Chromosome in Mouse-Human Cell Hybrids ( X chromosome inactivation / hypoxanthine phosphoribosyltransferase reappearance / X chromosome translocation / azaguanine-resistant fibroblasts ) (9)
- UDP-glucose: α-D-galactose-1-phosphate uridylyltransferase activity in cultured human fibroblasts (1967) (9)
- A new variant glyoxalase I allele that is readily detectable in stimulated lymphocytes and lymphoblastoid cell lines but not in circulating lymphocytes or erythrocytes. (1981) (8)
- Secretion and cell surface expression of IgG1 are impaired in human B lymphoblasts that lack HLA-A, -B, and -C antigens. (1989) (8)
- Diploid azaguanine-resistant mutants of cultured human fibroblasts. (1970) (7)
- Mapping of class I DNA sequences within the human major histocompatibility complex (2004) (6)
- A minimum of four human class II alpha-chain genes are encoded in the HLA region of chromosome 6. (1983) (6)
- Isolation of an HLA-A:,B:,C Null Human Cell Line Capable of Expressing Transferred Class I Genes (1989) (6)
- Function and specificity of human V gamma 9/V delta 2 T lymphocytes. (1991) (6)
- Analysis of DP Region Products by T Cells and Monoclonal Antibodies: Blocking of DP-Specific Proliferation and Cell-Mediated Cytotoxicity (1984) (6)
- Mutation studies with human fibroblasts. (1973) (5)
- Induction of 8-azaguanine-resistant human diploid fibroblasts by 2-nitrosofluorene☆ (1975) (5)
- A-11: Cell type-specific and single-active-X transcription controls of newly found gene in cultured human cells (1988) (5)
- The detection of HLA-DR, MB and MT determinants on purified class II molecules by inhibition of microcytotoxicity. (1984) (5)
- The origin of telocentric chromosomes in man: A girl with tel(Xq) (2004) (5)
- The remarkable cells cultured from a human with Hurler’s syndrome: An approach to visual selection forin vitro genetic studies (1966) (5)
- CD4+ proliferative T-cell clones reactive to autologous Epstein-Barr virus-transformed B cells (EBV-LCL) can be restricted by HLA class I molecules. (1988) (5)
- A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway. 1990. (1991) (5)
- Adenine phosphoribosyltransferase and hypoxanthine-guanine phosphoribosyltransferase immunoprecipitation reactions in human-mouse and human-hamster cell hybrids (1975) (4)
- Pillars Article: A Gene in the Human Major Histocompatibility Complex Class II Region Controlling the Class I Antigen Presentation Pathway. Nature 1990. 348: 744–747. (2008) (4)
- Isolation of a monoclonal antibody from a phage display library binding the rhesus macaque MHC class I allomorph Mamu-A1*001 (2017) (4)
- A tetrazolium method for distinguishing between cultured human fibroblasts having either normal or deficient levels of glucose-6-phosphate dehydrogenase (1967) (3)
- The proliferative immune response to autologous Epstein-Barr virus transformed lymphoblastoid cells. II. Studies with HLA class II loss variants demonstrate a role for gene products other than DR and DQ. (1986) (3)
- A T‐Cell Marker in Mouse Fibroblast × T‐Lymphocyte Somatic Cell Hybrids (1977) (3)
- 9.3-03 A non-classical class I antigen, HLA-G is expressed in human first trimester trophoblasts (1989) (3)
- Function and Specificity of Human Vγ9/Vδ2 T Lymphocytes (1991) (3)
- Derepression ofHPRT locus on inactive X chromosome of human lymphoblastoid cell line (1986) (3)
- Secretion and cell surface expression of IgG1 are impaired in human B lymphoblasts that lack HLA-A, -B, and -C antigens. (1990) (2)
- Mutations causing deficiency of adenine phospho ribosyl transferase ec 2.4.2.7 in fibroblasts cultured from human hetero zygous for mutant aprt alleles (1982) (2)
- Erratum: Secretion and cell surface expression of IgG1 are impaired in human B lymphoblasts that lack HLA-A, -B, and -C antigens (Proc. Natl. Acad. Sci. USA (October 1989) 86 (8005-8009)) (1990) (2)
- Comments about the Paper by Norwood et al. and an Idea Relating Somatic Cell Mutations to Cellular Senescence (1977) (2)
- HLA Class I Tetramers CTLs with + Membrane Protein-Specific CD 8 Major Outer Chlamydia trachomatis Direct Detection and Magnetic Isolation of DeMars and (2000) (2)
- PURINE REQUIREMENT OF CELLS CULTURED FROMHUMANS AFFECTED WITH LESCH-NYHAN SYNDROME (1)
- Evidence for chromatin structure as a regulatory determinant in HLA-DRαgene expression (2004) (1)
- Transfer and Expression of Human Non-A,B,C Class I Genes in Human HLA A,B,C Null Lymphoblastoid Cells (1989) (1)
- UDP-glucose: alpha-D-galactose-1-phosphate uridylytransferase activity in cultured human fibroblasts. (1967) (1)
- CHROMOSOMAL ORGANIZATION OF THE HUMAN MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I GENE FAMILY By BEVERLY H . KOLLER, DANIEL E . GERAGHTY, ROBERT DEMARS,* (2003) (1)
- Induction of azaguanine-resistant human diploid fibroblasts by N-methyl-N′-nitro-N-nitrosoguanidine (MNNG): quantitative studies (1978) (1)
- Phenotypic expression in T-lymphocyte x "fibroblast" cell hybrids. (1978) (1)
- Dissection of the human major histocompatibility complex with gamma-ray-induced mutations (1982) (0)
- The Production of Noninfectious Viral Components in Bacteria Infected With Bacteriophage (1953) (0)
- Letter from Robert DeMars to Salvador E. Luria (1954) (0)
- Conditions for the selection of azaguanine- or thioguanine-resistant human diploid fibroblasts (1978) (0)
- Derepression of HPRT locus on inactive X chromosome of human lymphoblastoid cell line. (1986) (0)
- Interstrain Gene Transfer in Chlamydia trachomatis In Vitro: Mechanism and Significance (cid:1) † (2008) (0)
- Evidence that gene products other than the known major histocompatibility complex class II determinants can stimulate a proliferative immune response (1985) (0)
- Human Genital Tract Infections Chlamydia trachomatis Membrane Protein of CTLs Specific for the Major Outer + Induction of HLA Class I-Restricted CD 8 (1999) (0)
- Evidence for chromatin structure as a regulatory determinant in HLA-DR alpha gene expression. (1985) (0)
- The HLA-D Region: Serology, Structure, Tissue Distribution, and Function of Human Class II Molecules and Their Antigenic Determinants (1984) (0)
- Letter from Robert DeMars to Joshua Lederberg (1954) (0)
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