Ralph Edward Durand
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Physics Biology
Ralph Edward Durand's Degrees
- PhD Biophysics University of California, Berkeley
- Masters Biochemistry Stanford University
Why Is Ralph Edward Durand Influential?
(Suggest an Edit or Addition)Ralph Edward Durand's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the "comet" assay. (1990) (627)
- Intermittent blood flow in a murine tumor: radiobiological effects. (1987) (458)
- Factors influencing DNA migration from individual cells subjected to gel electrophoresis. (1992) (368)
- Heterogeneity in Radiation-Induced DNA Damage and Repair in Tumor and Normal Cells Measured Using the “Comet” Assay (1990) (316)
- Effects of intercellular contact on repair of radiation damage. (1972) (305)
- Acute hypoxia in tumors: implications for modifiers of radiation effects. (1986) (297)
- Notch Activation Results in Phenotypic and Functional Changes Consistent With Endothelial-to-Mesenchymal Transformation (2004) (272)
- Cytotoxicity, Mutagenicity and DNA damage by Hoechst 33342. (1982) (227)
- Drug and radiation resistance in spheroids: cell contact and kinetics (1994) (207)
- Characterization of radiolabeled fluoromisonidazole as a probe for hypoxic cells. (1987) (198)
- The use of fluorescent probes to identify regions of transient perfusion in murine tumors. (1989) (187)
- Detection of etoposide resistance by measuring DNA damage in individual Chinese hamster cells. (1990) (179)
- Growth and cellular characteristics of multicell spheroids. (1984) (165)
- Spheroids in Cancer Research (1984) (158)
- Identification of nonproliferating but viable hypoxic tumor cells in vivo. (1998) (152)
- Gel electrophoresis of individual cells to quantify hypoxic fraction in human breast cancers. (1993) (147)
- Flow cytometry studies of intracellular adriamycin in multicell spheroids in vitro. (1981) (146)
- Pharmacokinetics, binding and distribution of Hoechst 33342 in spheroids and murine tumours. (1985) (144)
- Cell selection from a murine tumour using the fluorescent probe Hoechst 33342. (1985) (140)
- Measurements of relative biological effectiveness of the 70 MeV proton beam at TRIUMF using Chinese hamster V79 cells and the high-precision cell sorter assay. (1996) (127)
- Radiation response of multicell spheroids--an in vitro tumour model. (1976) (125)
- Quantifying Transient Hypoxia in Human Tumor Xenografts by Flow Cytometry (2004) (121)
- Use of Hoechst 33342 for cell selection from multicell systems. (1982) (120)
- Hypoxic cells in an in vitro tumour model. (1973) (109)
- Flow cytometry studies of intracellular adriamycin in single cells in vitro. (1981) (107)
- Resistance of tumor cells to chemo- and radiotherapy modulated by the three-dimensional architecture of solid tumors and spheroids. (2001) (105)
- CELL CYCLE KINETICS IN AN IN VITRO TUMOR MODEL (1976) (98)
- Comparison between pimonidazole binding, oxygen electrode measurements, and expression of endogenous hypoxia markers in cancer of the uterine cervix (2006) (94)
- Invited review Multicell spheroids as a model for cell kinetic studies (1990) (93)
- Distribution and activity of antineoplastic drugs in a tumor model. (1989) (91)
- Heterogeneity in DNA damage using the comet assay (2005) (90)
- Detection of hypoxic cells in a murine tumor with the use of the comet assay. (1992) (89)
- In vitro study of cell survival following dynamic MLC intensity-modulated radiation therapy dose delivery. (2007) (87)
- The comet assay: A new method to examine heterogeneity associated with solid tumors (1998) (84)
- Keynote address: the influence of microenvironmental factors on the activity of radiation and drugs. (1991) (84)
- Variable radiobiological responses of spheroids. (1980) (82)
- Chemosensitivity testing in V79 spheroids: drug delivery and cellular microenvironment. (1986) (81)
- Analysis of DNA damage in individual cells. (2001) (80)
- Use of a cell sorter for assays of cell clonogenicity. (1986) (80)
- Comparison between the comet assay and pimonidazole binding for measuring tumour hypoxia (2000) (73)
- Intermittent Blood Flow in Solid Tumours – an under-appreciated Source of ‘drug Resistance’ (2004) (73)
- Radioprotection by WR-2721 in vitro at low oxygen tensions: implications for its mechanisms of action. (1983) (71)
- Contribution of transient blood flow to tumour hypoxia in mice. (1995) (71)
- Dependence of the radiation response of an in vitro tumor model on cell cycle effects. (1973) (70)
- Growth and radiation survival characteristics of V79-171b Chinese hamster cells: a possible influence of intercellular contact. (1973) (68)
- The influence of microenvironmental factors during cancer therapy. (1994) (67)
- Fluorescent nitroheterocycles for identifying hypoxic cells. (1983) (65)
- Adriamycin: a possible indirect radiosensitizer of hypoxic tumor cells. (1976) (65)
- Orally administered pimonidazole to label hypoxic tumor cells. (2002) (62)
- DNA conformation of Chinese hamster V79 cells and sensitivity to ionizing radiation. (1986) (62)
- Cell killing, radiosensitization and cell cycle redistribution induced by chronic hypoxia. (1984) (60)
- The biological effectiveness of antiproton irradiation. (2006) (59)
- The lifetime of hypoxic human tumor cells. (1998) (59)
- Intermittent blood flow in the KHT sarcoma--flow cytometry studies using Hoechst 33342. (1990) (59)
- Physiologic and cytotoxic effects of tirapazamine in tumor-bearing mice. (1997) (58)
- Cure, regression and cell survival: a comparison of common radiobiological endpoints using an in vitro tumour model. (1975) (57)
- The effects of nitrobenzene derivatives on oxygen utilization and radiation response of an in vitro tumor model. (1976) (56)
- Evaluation of bioreductive drugs in multicell spheroids. (1992) (55)
- The comet assay in clinical practice. (1999) (52)
- Radiosensitization of hypoxic cells of an in vitro tumor model by respiratory inhibitors. (1977) (50)
- Development of apoptosis and polyploidy in human lymphoblast cells as a function of position in the cell cycle at the time of irradiation. (1996) (46)
- Effects of hyperthermia on the cycling, noncycling, and hypoxic cells of irradiated and unirradiated multicell spheroids. (1978) (46)
- The radiation response of asynchronous cells at low dose: evidence of substructure. (1991) (45)
- The radiosensitizing and toxic effects of RSU-1069 on hypoxic cells in a murine tumor. (1986) (41)
- Isolation of cell subpopulations from in vitro tumor models according to sedimentation velocity. (1975) (41)
- Potentiation of radiation lethality by hyperthermia in a tumor model: effects of sequence, degree, and duration of heating. (1978) (40)
- Slow penetration of anthracyclines into spheroids and tumors: a therapeutic advantage? (2008) (40)
- Hypoxic fractions measured in murine tumors and normal tissues using the comet assay. (1994) (40)
- Effect of intercellular contact on DNA conformation, radiation-induced DNA damage, and mutation in Chinese hamster V79 cells. (1985) (36)
- Apoptosis: an indicator of radiosensitivity in vitro? (1997) (35)
- Irradiation of multi-cell spheroids with fast neutrons versus X-rays: a qualitative difference in sub-lethal damage repair capacity or kinetics. (1976) (35)
- Flow cytometry techniques for studying cellular thiols. (1983) (35)
- The response of hypoxic cells in SCCVII murine tumors to treatment with cisplatin and x rays. (1991) (35)
- Detection of subpopulations resistant to DNA-damaging agents in spheroids and murine tumours. (1997) (34)
- Radiosensitization of hypoxic cells at low doses. (1986) (33)
- Radiobiological Intercomparison of the 160 MeV and 230 MeV Proton Therapy Beams at the Harvard Cyclotron Laboratory and at Massachusetts General Hospital (2015) (33)
- Substructure in the radiation survival response at low dose in cells of human tumor cell lines. (1996) (32)
- Evaluation of Nitroheterocyclic Radiosensitizers Using Spheroids (1981) (31)
- Hypoxic Radiosensitizers and Cellular Respiration (1976) (31)
- Activation of radiosensitizers by hypoxic cells. (1978) (30)
- Radiosensitization by nifuroxime of the hypoxic cells in an in vitro tumour model. (1972) (30)
- Letter: Modification of the radiation response of an in vitro tumour model by control of cellular respiration. (1974) (29)
- Tumour blood flow influences combined radiation and doxorubicin treatments. (1997) (29)
- Modulation of tumor hypoxia by conventional chemotherapeutic agents. (1994) (28)
- Oxygen enhancement ratio in V79 spheroids. (1983) (28)
- Endogenous and radiation-induced expression of gammaH2AX in biopsies from patients treated for carcinoma of the uterine cervix. (2010) (28)
- Cell contact as a possible contribution to radiation resistance of some tumours. (1972) (25)
- Tumor resistance to therapy: a genetic or kinetic problem? (1989) (25)
- Etoposide sensitivity and topoisomerase II activity in Chinese hamster V79 monolayers and small spheroids. (1991) (25)
- Evidence for intermittent radiobiological hypoxia in experimental tumour systems. (1989) (25)
- Calibration of flow cytometry detector systems. (1981) (24)
- Cell kinetics and repopulation mechanisms during multifraction irradiation of spheroids. (1998) (22)
- Use of the comet assay for assessment of drug resistance and its modulation in vivo. (1998) (22)
- Radiation-induced DNA damage in V79 spheroids and monolayers. (1979) (22)
- New Thiol Active Fluorophores for Intracellular Thiols and Glutathione Measurement (1996) (22)
- Radiosensitisation and radioprotection by BSO and WR-2721: the role of oxygenation. (1989) (21)
- Functional assessment of cutaneous microvasculature after radiation. (1999) (21)
- Synergism of cisplatin and mitomycin C in sensitive and resistant cell subpopulations of a tumor model (1989) (21)
- The Range of Oxygenation in SiHa Tumor Xenografts (2002) (20)
- Repair and proliferation: major determinants of the multifraction radiation response. (1988) (20)
- Determining Tpot in heterogeneous systems: a new approach illustrated with multicell spheroids. (1993) (20)
- Interaction of etoposide and cisplatin in an in vitro tumor model. (1987) (20)
- Drug-induced alterations in tumour perfusion yield increases in tumour cell radiosensitivity (2001) (19)
- Predicting response to treatment in human cancers of the uterine cervix: sequential biopsies during external beam radiotherapy. (2004) (19)
- Radiation studies with spheroids. (1984) (19)
- Characterization of a carbocyanine derivative as a fluorescent penetration probe. (1987) (19)
- Repair and reoxygenation following irradiation of an in vitro tumor model. (1976) (19)
- Cisplatin and CCNU synergism in spheroid cell subpopulations. (1990) (19)
- Roles of thiols in cellular radiosensitivity. (1984) (19)
- Tumor repopulation during radiotheraphy: quantitation in two xenografted human tumors. (1997) (18)
- Repopulation characteristics and cell kinetic parameters resulting from multi-fraction irradiation of xenograft tumors in SCID mice. (1999) (18)
- Comparison between the binding of [3H]misonidazole and AF-2 in Chinese hamster V79 spheroids. (1986) (18)
- The enhanced radiation response of an in vitro tumour model by cyanide released from hydrolysed amygdalin. (1978) (18)
- Cell sorting with Hoechst or carbocyanine dyes as perfusion probes in spheroids and tumors. (1990) (16)
- Tumour cell kinetics and heterogeneity: insights from multicell spheroids. (1992) (16)
- Radiation-resistant tumor cells may be more sensitive in vitro. (1972) (16)
- Schedule dependence for cisplatin and etoposide multifraction treatments of spheroids. (1990) (16)
- Survival at low dose in asynchronous and partially synchronized Chinese hamster V79-171 cells. (1993) (15)
- Effects of sensitizers on cell respiration: 1. Factors influencing the effects of hypoxic cell radiosensitizers on oxygen utilization of tumour and cultured mammalian cells. (1978) (15)
- Heterogeneity in radiation induced dna damage and repair measured using the comet assay (1990) (14)
- Effects of sensitizers on cell respiration: II. The effects of hypoxic cell sensitizers on oxygen utilization in cellular and chemical models. (1978) (14)
- The effect of hydralazine on blood flow and misonidazole toxicity in human tumour xenografts. (1991) (13)
- Effects of lucanthone on Chinese hamster V-79 cells. I. Interaction with radiation in monolayers and spheroids. (1980) (13)
- Uptake and mutagenicity of AF‐2 in chinese hamster V‐79 spheroids under aerobic and hypoxic conditions (1981) (13)
- Misonidazole binding in SCCVII tumors in relation to the tumor blood supply. (1989) (13)
- Combination adriamycin/misonidazole toxicity in V79 spheroids. (1982) (11)
- Effects of injection volume on the tissue dose, dose rate, and therapeutic potential intraperitoneal 32p. (1981) (11)
- Repair during multifraction exposures: spheroids versus monolayers. (1984) (11)
- Cytotoxicity of RSU 1069 in spheroids and murine tumors. (1987) (10)
- Cellular oxygen utilization and radiation response of V-79 spheroids. (1983) (10)
- Characterization of the uptake and toxicity of a fluorescent thiol reagent. (1983) (10)
- Effects of mitomycin C on the oxygenation and radiosensitivity of murine and human tumours in mice. (2000) (10)
- The oxygen enhancement ratio for high energy neutrons. (1977) (9)
- Calibration of flow cytometer detector systems. (1994) (9)
- Sequencing radiation and adriamycin exposures in spheroids to maximize therapeutic gain. (1989) (9)
- Penetration of AF-2 and 4NQO into multicell spheroids. (1983) (9)
- The fate of hypoxic (pimonidazole-labelled) cells in human cervix tumours undergoing chemo-radiotherapy. (2006) (9)
- Chemosensitization by misonidazole in CCNU-treated spheroids and tumours. (1987) (8)
- Cell kinetics and repopulation parameters of irradiated xenograft tumours in SCID mice: comparison of two dose-fractionation regimens. (1999) (8)
- Effects of sensitizers on cell respiration: III. The effects of hypoxic cell radiosensitizers on oxidative metabolism and the radiation response of an in vitro tumour model. (1978) (8)
- Respiration-induced oxygen gradients in cultured mammalian cells. (1990) (8)
- On the mechanism for enhancement of tumor radiation to hyperbaric oxygen in sodium pentobarbital anesthetized rodents. (1984) (7)
- Effects Intermittent Blood Flow in a Murine Tumor : Radiobiological Updated (1987) (7)
- Fast neutron effects on multicell spheroids. (1977) (7)
- Nitropyrrole radiosensitizers: structure function relationships. (1978) (7)
- Potentiation of CCNU toxicity by AF-2 in V79 spheroids: implications for mechanisms of chemosensitization. (1986) (7)
- DNA strand breakage in Chinese hamster V79 cells caused by low levels of incorporated [3H] and [14C]thymidine. (1987) (6)
- The enhanced radiation response of in vitro tumor models to insulin. (1979) (6)
- Contributions of flow cytometry to studies with multicell spheroids. (1994) (6)
- [Contribution to the pharmacology and toxicology of different extracts as well as the harpagosid from Harpagophytum procumbens DC (author's transl)]. (1978) (4)
- Chapter 34 Calibration of Flow Cytometer Detector Systems (1994) (4)
- Repair, redistribution and repopulation in V79 spheroids during multifraction irradiation (1994) (4)
- Enhancement of toxicity from N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea in V79 spheroids by a nitrofuran. (1987) (4)
- Effects of lucanthone on Chinese hamster V-79 cells. II. Damage to DNA. (1980) (4)
- Low dose-rate irradiation of multicell spheroids. (1978) (4)
- 2nd International Spheroid congress at the Max-Planck-institute for systemphysiology in Dortmund, June 29-July 1 1983 (1984) (3)
- Development of tetraploidy in V79 spheroids (1982) (3)
- The biological activity of cisplatin and dibromodulcitol in combination therapy. (1995) (2)
- SU‐FF‐T‐460: Comparative in Vitro Study of Cell Survival Following IMRT and Acute Dose Delivery (2006) (2)
- P23 14 WP – DNA DOUBLE-STRAND BREAKS DETECTED IN INDIVIDUAL CELLS (1991) (1)
- Calibration of flow cytometer detector systems. (1990) (1)
- P XIV B.13 The comet assay: Alternatives for quantitative analyses (1997) (1)
- Response of cell subpopulations in spheroids to radiation-drug combinations. (1988) (1)
- Cells in Vivo Identification of Nonproliferating but Viable Hypoxic Tumor (2013) (0)
- absorbent composite material, preparation and use, in particular as an article of industrial wiping (1999) (0)
- P08 15 SP – REPAIR, REDISTRIBUTION AND REPOPULATION DURING MULTIFRACTION IRRADIATION OF V79 SPHEROIDS (1991) (0)
- Flow Cytometry Studies of Intracellular Adriamycin in Multiceli Spheroids in Wfro1 (2006) (0)
- 106 the influence of carbon dioxide content on peripheral microvascular blood flow and tumour oxygen tension (1999) (0)
- Sci-Sat AM (1) General-01: In vitro measurement of cell kill by IMRT fields (2006) (0)
- Multicell Spheroids - An in Vitro Model of Normal and Malignant Tissues (1979) (0)
- Enhancement of Toxicity from AH2-Chloroethyl)-Af'-cyclohexyI-./V-nitrosourea in V79 Spheroids by a Nitrofuran1 (2006) (0)
- Growth And Radiation Survival Characteristics Of Cells In An In Vitro Tumor Model (1973) (0)
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What Schools Are Affiliated With Ralph Edward Durand?
Ralph Edward Durand is affiliated with the following schools:
