Robert E. Handschumacher

Robert E. Handschumacher's AcademicInfluence.com Rankings

Biology

#9804

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#13052

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Biochemistry

#1512

World Rank

#1641

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Biology

Robert E. Handschumacher's Degrees

PhD Biochemistry University of California, Berkeley
Bachelors Chemistry University of California, Berkeley

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Robert E. Handschumacher's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Cyclophilin: a specific cytosolic binding protein for cyclosporin A. (1984) (1549)
Isolation and amino acid sequence of cyclophilin. (1986) (246)
L-asparaginase: clinical, biochemical, pharmacological, and immunological studies. (1971) (188)
Leukocyte chemotactic activity of cyclophilin. (1992) (187)
Cyclophilin: distribution and variant properties in normal and neoplastic tissues. (1986) (185)
The Cyclosporin A-binding Immunophilin CyP-40 and the FK506-binding Immunophilin hsp56 Bind to a Common Site on hsp90 and Exist in Independent Cytosolic Heterocomplexes with the Untransformed Glucocorticoid Receptor (*) (1995) (180)
A rapid quantitative determination of deoxyribonucleoside triphosphates based on the enzymatic synthesis of DNA. (1969) (156)
L-asparaginase and L-asparagine metabolism. (1970) (147)
Purification and properties of human lymphocyte activating factor (LAF). (1977) (146)
Novel single-pass exchange of circulating uridine in rat liver. (1981) (129)
The biochemical activity of 6-azauridine: interference with pyrimidine metabolism in transplantable mouse tumors. (1959) (127)
Evaluation of L-asparagine metabolism in animals and man. (1970) (119)
Partial purification of human lymphocyte-activating factor (LAF) by ultrafiltration and electrophoretic techniques. (1977) (117)
Preparation of lymphocyte-activating factor from continuous murine macrophage cell lines. (1977) (116)
Salvage of circulating pyrimidine nucleosides in the rat. (1981) (115)
Potentiation of the T lymphocyte response to mitogens. III. Properties of the mediator(s) from adherent cells. (1974) (115)
Inhibition of orotidylic acid decarboxylase, a primary site of carcinostasis by 6-azauracil. (1958) (115)
Homeostatic control of uridine and the role of uridine phosphorylase: a biological and clinical update. (2002) (106)
Cyclophilin-40, a protein with homology to the P59 component of the steroid receptor complex. Cloning of the cDNA and further characterization. (1993) (102)
Isolation and characterization of a 40-kDa cyclophilin-related protein. (1992) (96)
Cyclosporin A potentiates the dexamethasone-induced mouse mammary tumor virus-chloramphenicol acetyltransferase activity in LMCAT cells: a possible role for different heat shock protein-binding immunophilins in glucocorticosteroid receptor-mediated gene expression. (1995) (96)
551. Chemical studies in the biosynthesis of purine nucleotides. Part I. The preparation of N-glycylglycosylamines (1956) (96)
Clinical, Biological, and Biochemical Effects of Pyrazofurin (1978) (95)
Immunological responses to L-asparaginase. (1971) (86)
Escherichia coli L-asparaginase. Catalytic activity and subunit nature. (1970) (84)
Selective inhibition of pyrimidine synthesis and depletion of nucleotide pools by N-(phosphonacetyl)-L-aspartate. (1979) (83)
Fatty livers induced by orotic acid. II. Changes in nucleotide metabolism. (1963) (81)
Tissue uridine pools: evidence in vivo of a concentrative mechanism for uridine uptake. (1986) (80)
Concentrative uridine transport by murine splenocytes: kinetics, substrate specificity, and sodium dependency. (1987) (75)
Control of the formation of uridine diphospho-N-acetyl-hexosamine and glycoprotein synthesis in rat liver. (1966) (74)
Role of uridine phosphorylase in the anabolism of 5-fluorouracil. (1985) (69)
Fatty livers induced by orotic acid. I. Accumulation and metabolism of lipids. (1961) (67)
Studies on the Carcinostatic Activity in Mice of 6-Azauracil Riboside (Azauridine), In Comparison with that of 6-Azauracil ‡ (1957) (65)
Expression, characterization, and detection of human uridine phosphorylase and identification of variant uridine phosphorolytic activity in selected human tumors. (1998) (64)
5-Diazo-4-Oxo-L-Norvaline: Reactive Asparagine Analog with Biological Specificity (1968) (64)
Orotidylic acid decarboxylase: inhibition studies with azauridine 5'-phosphate. (1960) (63)
Toxoplasma gondii tachyzoites possess an unusual plasma membrane adenosine transporter. (1995) (62)
Cyclophilin-40: evidence for a dimeric complex with hsp90. (1995) (62)
Clinical and pharmacological studies with 2',3',5'-triacetyl-6-azauridine. (1963) (62)
BIOCHEMICAL AND NUTRITIONAL STUDIES ON THE INDUCTION OF FATTY LIVERS BY DIETARY OROTIC ACID. (1960) (61)
Isolation, cDNA sequences, and biochemical characterization of the major cyclosporin-binding proteins of Toxoplasma gondii. (1994) (60)
Summary of current information on 6-azauridine. (1962) (59)
CYCLOPHILIN, A PRIMARY MOLECULAR TARGET FOR CYCLOSPORINE (1988) (58)
Pyrazofurin metabolism, enzyme inhibition, and resistance in L5178Y cells. (1979) (57)
Studies of bacterial resistance to 6-azauracil and its riboside. (1957) (56)
Specific interaction of the cyclophilin-cyclosporin complex with the B subunit of calcineurin. (1993) (54)
Alterations in pyrimidine metabolism in L5178Y leukemia cells resistant to 6-azauridine. (1961) (54)
Microbial studies of 6-azauracil, an antagonist of uracil. (1956) (52)
Fluoroolefin peptide isosteres - tools for controlling peptide conformations (1994) (50)
CHAPTER 39 – Agents Which Influence Nucleic Acid Metabolism (1960) (48)
Defective facilitated diffusion of nucleosides, a primary mechanism of resistance to 5-fluoro-2'-deoxyuridine in the HCT-8 human carcinoma line. (1985) (47)
Enhancement of anthracycline growth inhibition in parent and multidrug-resistant Chinese hamster ovary cells by cyclosporin A and its analogues. (1989) (47)
Induction of the differentiation of HL-60 cells by phorbol 12-myristate 13-acetate activates a Na(+)-dependent uridine-transport system. Involvement of protein kinase C. (1991) (46)
Selective antagonism of 5-fluorouracil cytotoxicity by 4-hydroxypyrazolopyrimidine (allopurinol) in vitro. (1979) (45)
Allopurinol modification of the toxicity and antitumor activity of 5-fluorouracil. (1980) (44)
Serum Haptoglobin in Patients with Ovarian Malignancies (1971) (43)
Calmodulin, cyclophilin, and cyclosporin A. (1986) (43)
Alterations in human pyrimidine metabolism as a result of therapy with 6-azauridine. (1961) (43)
Identification of two calcineurin B-binding proteins: tubulin and heat shock protein 60. (2002) (42)
Phase I clinical and pharmacological studies of benzylacyclouridine, a uridine phosphorylase inhibitor. (1998) (39)
The immunochemical distribution of cyclophilin in normal mammalian tissues. (1991) (39)
Kinetics of N-(phosphonacetyl)-L-aspartate and pyrazofurin depletion of pyrimidine ribonucleotide and deoxyribonucleotide pools and their relationship to nucleic acid synthesis in intact and permeabilized cells. (1982) (39)
Aberrant cell cycle inhibition pattern in human colon carcinoma cell lines after exposure to 5-fluorouracil. (1995) (36)
The relationship between the penetration of tryptamine and 5-hydroxytryptamine into smooth muscle and the associated contractions. (1967) (33)
Enhancement of fluorouracil therapy by the manipulation of tissue uridine pools. (1989) (33)
Nonspecific "lymphocyte activating" factors produced by macrophages. (1979) (32)
AN ANALYSIS OF THE LACK OF DRUG SYNERGISM DURING SEQUENTIAL BLOCKADE OF DE NOVO PYRIMIDINE BIOSYNTHESIS. (1964) (32)
Control of purine biosynthesis de novo by orotic acid in vivo and in vitro. (1968) (31)
Inhibition of the synthesis of deoxyribonucleic acid in bacteria by 6-(p-hydroxyphenylazo)-2,4-dihydroxypyrimidine. I. Metabolic studies in Streptococcus fecalis. (1966) (31)
A synopsis of recent investigations of 6-azauridine (NSC-32074). (1960) (30)
Studies on the pharmacology of 6-azauracil. (1960) (29)
PATHOGENESIS OF OROTIC ACID-INDUCED FATTY CHANGE IN THE RAT LIVER: LIGHT AND ELECTRON MICROSCOPIC STUDIES. (1965) (28)
5-azaorotic acid and related inhibitors of the synthesis de novo of pyrimidine nucleotides. (1963) (27)
Structure of peptide from active site region of Escherichia coli L-asparaginase. (1977) (26)
Expression of human cyclophilin-40 and the effect of the His141-->Trp mutation on catalysis and cyclosporin A binding. (1995) (24)
Brequinar potentiates 5-fluorouracil antitumor activity in a murine model colon 38 tumor by tissue-specific modulation of uridine nucleotide pools. (1992) (24)
A method for the purification of coenzyme A from yeast. (1953) (24)
A METHOD FOR PURIFICATION OF COENZYME A (1952) (22)
Peptidyl-prolyl cis-trans isomerase activity of cyclophilin studied by one-dimensional proton nuclear magnetic resonance spectroscopy (1990) (22)
Differentiation of HL-60 cells by dimethylsulfoxide activates a Na(+)-dependent nucleoside transport system. (1994) (21)
Cyclophilin, a primary molecular target for cyclosporine. Structural and functional implications. (1988) (21)
Benzylacyclouridine. Pharmacokinetics, metabolism and biochemical effects in mice. (1988) (20)
1H NMR studies on bovine cyclophilin: preliminary structural characterization of this specific cyclosporin A binding protein. (1986) (20)
The rate of mutation of L5178Y asparagine-dependent mouse leukemia cells to asparagine independence and its biological consequences. (1973) (20)
Bradykinin and its Gly6 analogue are substrates of cyclophilin: a fluorine-19 magnetization transfer study. (1990) (20)
Effect of clinically modeled regimens on the growth response and development of resistance in human colon carcinoma cell lines. (1995) (19)
Activity of cyclosporin A and a non-immunosuppressive cyclosporin against multidrug resistant leukemic cell lines. (1989) (19)
Inactivation and resynthesis of glucosamine-6-phosphate synthetase after treatment with glutamine analogs. (1969) (19)
Isolation and partial characterization of membrane-associated cyclophilin and a related 22-kDa glycoprotein. (1992) (17)
The Stability of Coenzyme A1 (1954) (17)
Pharmacokinetic and phase I trial of intraperitoneal carboplatin and cyclosporine in refractory ovarian cancer patients. (1997) (17)
An improved enzymatic assay for coenzyme A. (1951) (16)
Hepatic homeostasis of plasma L-asparagine. (1971) (16)
L5178Y asparagine-dependent cells and independent clonal sublines. Toxicity of 5-diazo-4-oxo-L-norvaline. (1971) (16)
Genomic structure, chromosomal mapping, and promoter region analysis of murine uridine phosphorylase gene. (1999) (16)
1H NMR studies on bovine cyclophilin: preliminary structural characterization of its complex with cyclosporin A. (1990) (16)
Structural elements pertinent to the interaction of cyclosporin A with its specific receptor protein, cyclophilin. (1990) (15)
Tissue-specific expansion of uridine pools in mice. Effects of benzylacyclouridine, dipyridamole and exogenous uridine. (1991) (15)
Effects of asparagine synthetase inhibitors on asparaginase resistant tumors. (1977) (14)
HIV protease substrate conformation: modulation by cyclophilin A (1997) (14)
Inhibition by pertussis toxin of the activation of Na(+)-dependent uridine transport in dimethyl-sulphoxide-induced HL-60 leukaemia cells. (1991) (14)
Cyclophilin binding: a receptor-mediated approach to monitoring cyclosporine immunosuppressive activity following organ transplantation. (1990) (14)
New asparagine analogs. (1973) (14)
Regulation of the nuclear factor of activated T cells in stably transfected Jurkat cell clones. (1996) (14)
Enzymatic and nutritional evidence for two-stage exression of the asparagine synthetase locus in L5178y murine leukemia mutants. (1974) (14)
Conference on obstacles to the control of acute leukemia. Formal discussion: some enzymatic considerations in combination chemotherapy. (1965) (13)
Production of L-asparagine by tumor cells and the effect of asparagine analogs. (1972) (13)
Renal tubular excretion studies with pyrimidine derivatives and analogs. (1962) (13)
Discrete roles of hepatocytes and nonparenchymal cells in uridine catabolism as a component of its homeostasis. (1998) (13)
Metabolic and biochemical effects of 6-azacytidine in mice with Ehrlich ascites carcinoma (1963) (12)
β-Alanine and α-fluoro-β-alanine concentrative transport in rat hepatocytes is mediated by GABA transporter GAT-2. (1999) (12)
Clinical, biological, and biochemical effect of pyrazofurin. (1978) (11)
Pharmacological and clinical studies with triacetyl 6-azauridine. (1962) (11)
Effects of uridine on the growth and differentiation of HL-60 leukemia cells. (1991) (11)
Bacterial Preparation of Orotidine-5′-phosphate and Uridine-5′-phosphate (1958) (11)
Hepatic regulation of plasma L-asparagine. (1973) (10)
Nitroasparaginase. Subunit cross-linkage and altered substrate specificity. (1972) (10)
Uridine Phosphorylase Association with Vimentin (2001) (10)
Preparation and purification of coenzyme A concentrates. (1951) (9)
Characterization of lymphocyte activating factor from mouse tumor cell lines and human leukocytes (1976) (9)
Highly selective drug combinations for human colon cancer cells resistant in vitro to 5-fluoro-2'-deoxyuridine. (1985) (9)
Modification of L-asparaginase by subunit cross-linking with dimethylsuberimidate. (1972) (9)
beta-alanine and alpha-fluoro-beta-alanine concentrative transport in rat hepatocytes is mediated by GABA transporter GAT-2. (1999) (9)
Abortifacient and teratogenic effects of triacetyl-6-azauridine in the monkey. (1970) (8)
Cyclosporine--mechanism of action. (1988) (8)
Purification and properties of orotidylate decarboxylases from yeast and rat liver. (1961) (8)
Hepatic and biliary transport of orotate and its metabolic consequences. (1979) (8)
Concentration of bound pantothenic acid. (1950) (8)
Tissue-specific enhancement of uridine utilization and 5-fluorouracil therapy in mice by benzylacyclouridine. (1985) (8)
Modulation of doxorubicin dox resistance by cyclosporin a csa and a non immunosuppressive homolog (1987) (7)
Altered plasma kinetics of 5-FU at high dosage in rat and man. (1985) (7)
The interaction between lysozyme and penicillin. (1967) (7)
ISOLATION AND CHARACTERIZATION OF LOW DENSITY STRUCTURES FROM OROTIC ACID-INDUCED FATTY LIVERS (1969) (7)
The influence of certain antimetabolites on the incorporation of orotic acid into pseudouridine in animals. (1963) (7)
Investigation of l-asparagine metabolism in animals and human sub- jects. Abstr. (1968) (7)
Immunity, microbial pathogenesis, and immunophilins: finding the keys, now where are the locks? (1992) (6)
Correction: Uptake and Nature of the Intracellular Binding of Cyclosporin A in a Murine Thymoma Cell Line, BW5147 (1984) (5)
Azauracil ribonucleoside and ribonucleotides: isolation and chemical synthesis. (1960) (5)
Nonspecific "lymphocyte activating" factors produced by macrophages. (1979) (5)
Physical and biological properties of acetamidino-, beta-dimethylaminopropionamidino-, and maleyl-L-asparaginase. (1973) (5)
Cyclophilin binding: a more accurate measure of cyclosporine immunosuppressive activity after renal transplantation. (1991) (5)
Concentrative transport of adenosine in murine splenocytes: limitation by an ecto-adenosine deaminase. (1995) (4)
The active site of L-asparaginase: dimethylsulfoxide effect of 5-diazo-4-oxo-L-norvaline interactions. (1976) (4)
Synthesis of model compounds relevant to the active-site-directed inactivation of L-asparaginase by 5-diazo-4-oxo-L-norvaline. (2009) (4)
Effects of n-(phosphonacetyl)-l-aspartate (pala) on circulating pyrimidine nucleosides, nucleotide pools, and nucleic acid synthesis. Abstr. (1980) (4)
METHODS FOR DETERMINATION OF PERMEABILITY OF CELLS TO DRUGS. (1964) (3)
Effect of herpes simplex virus type 1 infection on nucleoside transport in HeLa S3 cells. (1990) (3)
Aspects of pharmacology pertinent to the skin (1974) (3)
The decarboxylation of 5‐azaorotic acid (1967) (3)
Nonspecific "lymphocyte activating" factors produced by macrophages. (1979) (3)
Symposium on estrogen receptor determination with monoclonal antibodies. Monte Carlo, December 14, 1984. (1986) (3)
Discrete roles of hepatocytes and nonparenchymal cells in uridine catabolism as a component of its homeostasis. (1998) (2)
Two different metabolic fates of 5-ethyl-6-azauracil in mice. (1963) (2)
A Small-Angle X-ray Scattering Study of the Binding of Cyclosporin A to Cyclophilin (1995) (2)
Structural and regulatory aspects of enzymes in chemotherapy. (1969) (2)
Asparaginase. Stereochemistry of the active center as determined by circular dichroism of substrates. (1973) (2)
Fluoroolefin Peptide Isosteres - Tools for Controlling Peptide Conformations. (1995) (2)
Some considerations in the design of new antineoplastic agents (1977) (2)
Antagonism of 5-fluorouracil (5fu) growth inhibition and toxicity by allopurinol (al) and pyrazofurin (pf). Abstr. (1978) (1)
NMR methods for elucidating macromolecule-ligand interactions: an approach to drug design. Proceedings of the Fourth Biochemical Pharmacology Symposium. New Haven, CT, 27-29 July 1989. (1990) (1)
NMR methods for elucidating macromolecule-ligand interactions: an approach to drug design. Proceedings of the Fourth Biochemical Pharmacology Symposium. New Haven, CT, 27-29 July 1989. (1990) (1)
NEW ASPARAGINE ANALOGS (1974) (1)
Convenient method for preparation of coenzyme (1952) (1)
Active site of L-asparaginase: reaction with diazo-4-oxonorvaline. (1977) (1)
Kinetic mechanism of l-asparagine synthetase of 6c3hed-rg1 tumor. Abstr. (1970) (1)
Alternative protein ligands of calcineurin b: Ca++dependent interaction with tubulin and heat shock protein 60 (1996) (1)
The possible role of laf as a physiological mediator in the immune response. Abstr. (1975) (1)
Enzymatic formation of uracil and azauriail nucleotides in Streptococcus faecalis. (1966) (1)
An overview of recent progress in ligand-receptor research based on nuclear magnetic resonance spectroscopy. (1990) (1)
Tamoxifen induces Na+ -dependent uridine transport and dome formation in a human breast tumor cell line. (1995) (0)
Some Principles of Energetics in Biochemical Reactions (1957) (0)
Examination of the action of cyclosporin a (cya) on a malignant t cell line, bw5147. Abstr. (1982) (0)
Tumor cell lysis by disruption of sulfhydryl-disulfide equilibra. Abstr. (1975) (0)
Experimental Chemotherapy (1963) (0)
Two-dimensional /sup 1/H NMR studies on cyclophilin, a cytosolic cyclosporin A binding protein (1986) (0)
Allopurinol Modificationof the Toxicityand AntitumorActivityof 5-Fluorouracil' (1980) (0)
Cyclophilin represents a novel class of protein kinases (1987) (0)
Orotidylic Acid Decarboxylase: Inhibition Studies (2003) (0)
Analysis of t cell ontogeny in mitogenized thymocyte populations by cyclosporin a. Abstr. (1979) (0)
Evaluation of Lâ€ ̃AsparagineMetabolism Lâ€ ̃AsparagineMetabolism Lâ€ ̃AsparagineMetabolism in Animals and Man ' (2006) (0)
Comparison of the metabolism and biochemical effects of 6-azacytidine (azcr) and 6-azauridine (azur). Abstr. (1963) (0)
AND L-ASP ARAGINE MET ABOLISM1 (1970) (0)
Phosphorolytic Activity in Selected Human Tumors Phosphorylase and Identification of Variant Uridine Expression , Characterization , and Detection of Human Uridine Updated (2006) (0)
SOME CONSEQUENCES OF INHIBITION OF THE DE NOVO PATHWAY OF PYRIMIDINE BIOSYNTHESIS (1979) (0)
Augmentation of doxorubicin and 4' epidoxorubicin in parental and multidrug-resistant chinese hamster ovary cell lines by cyclosporin A and its nonimmunosuppressive homologs (1989) (0)
Riboside of 1,2,4-triazine-3,5(2H, 4H)-dione (I; R=H) (6-azauracil), which interupts pyrimidine nucleoside formation by inhibition of orotydylic acid decarboxylase through conversion to its 5'-monophosphate6) in some mutant of microorganisms7,8) or mam- (2010) (0)
Differential actions of oxonate and oxaidin on pyrimidine metabolism in livers and tumors. Abstr. (1962) (0)
DETERMINATION OF ALTERATIONS IN METABOLISM OF PYRIMIDINES AND THEIR ANALOGS. (1964) (0)
Cancer chemotherapy: examples of current progress and future perspectives (1984) (0)
PYRIMIDINE METABOLISM AS A TARGET FOR CHEMOTHERAPY (1968) (0)
Cyclosporin a inhibition of normal and malignant thymus derived cell lines (1980) (0)
Region Analysis of Murine Uridine Phosphorylase Gene Genomic Structure , Chromosomal Mapping , and Promoter Updated (1999) (0)
OXONATE AND OTHER RELATED ANTIMETABOLITES OF THE SYNTHESIS DE NOVO OF PYRIMIDINE NUCLEOTIDES. (1964) (0)

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What Schools Are Affiliated With Robert E. Handschumacher?

Robert E. Handschumacher is affiliated with the following schools:

Yale University