Robert E. Handschumacher
#139,514
Most Influential Person Now
Robert E. Handschumacher's AcademicInfluence.com Rankings
Robert E. Handschumacherbiology Degrees
Biology
#9804
World Rank
#13052
Historical Rank
Biochemistry
#1512
World Rank
#1641
Historical Rank

Download Badge
Biology
Robert E. Handschumacher's Degrees
- PhD Biochemistry University of California, Berkeley
- Bachelors Chemistry University of California, Berkeley
Why Is Robert E. Handschumacher Influential?
(Suggest an Edit or Addition)Robert E. Handschumacher's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Cyclophilin: a specific cytosolic binding protein for cyclosporin A. (1984) (1549)
- Isolation and amino acid sequence of cyclophilin. (1986) (246)
- L-asparaginase: clinical, biochemical, pharmacological, and immunological studies. (1971) (188)
- Leukocyte chemotactic activity of cyclophilin. (1992) (187)
- Cyclophilin: distribution and variant properties in normal and neoplastic tissues. (1986) (185)
- The Cyclosporin A-binding Immunophilin CyP-40 and the FK506-binding Immunophilin hsp56 Bind to a Common Site on hsp90 and Exist in Independent Cytosolic Heterocomplexes with the Untransformed Glucocorticoid Receptor (*) (1995) (180)
- A rapid quantitative determination of deoxyribonucleoside triphosphates based on the enzymatic synthesis of DNA. (1969) (156)
- L-asparaginase and L-asparagine metabolism. (1970) (147)
- Purification and properties of human lymphocyte activating factor (LAF). (1977) (146)
- Novel single-pass exchange of circulating uridine in rat liver. (1981) (129)
- The biochemical activity of 6-azauridine: interference with pyrimidine metabolism in transplantable mouse tumors. (1959) (127)
- Evaluation of L-asparagine metabolism in animals and man. (1970) (119)
- Partial purification of human lymphocyte-activating factor (LAF) by ultrafiltration and electrophoretic techniques. (1977) (117)
- Preparation of lymphocyte-activating factor from continuous murine macrophage cell lines. (1977) (116)
- Salvage of circulating pyrimidine nucleosides in the rat. (1981) (115)
- Potentiation of the T lymphocyte response to mitogens. III. Properties of the mediator(s) from adherent cells. (1974) (115)
- Inhibition of orotidylic acid decarboxylase, a primary site of carcinostasis by 6-azauracil. (1958) (115)
- Homeostatic control of uridine and the role of uridine phosphorylase: a biological and clinical update. (2002) (106)
- Cyclophilin-40, a protein with homology to the P59 component of the steroid receptor complex. Cloning of the cDNA and further characterization. (1993) (102)
- Isolation and characterization of a 40-kDa cyclophilin-related protein. (1992) (96)
- Cyclosporin A potentiates the dexamethasone-induced mouse mammary tumor virus-chloramphenicol acetyltransferase activity in LMCAT cells: a possible role for different heat shock protein-binding immunophilins in glucocorticosteroid receptor-mediated gene expression. (1995) (96)
- 551. Chemical studies in the biosynthesis of purine nucleotides. Part I. The preparation of N-glycylglycosylamines (1956) (96)
- Clinical, Biological, and Biochemical Effects of Pyrazofurin (1978) (95)
- Immunological responses to L-asparaginase. (1971) (86)
- Escherichia coli L-asparaginase. Catalytic activity and subunit nature. (1970) (84)
- Selective inhibition of pyrimidine synthesis and depletion of nucleotide pools by N-(phosphonacetyl)-L-aspartate. (1979) (83)
- Fatty livers induced by orotic acid. II. Changes in nucleotide metabolism. (1963) (81)
- Tissue uridine pools: evidence in vivo of a concentrative mechanism for uridine uptake. (1986) (80)
- Concentrative uridine transport by murine splenocytes: kinetics, substrate specificity, and sodium dependency. (1987) (75)
- Control of the formation of uridine diphospho-N-acetyl-hexosamine and glycoprotein synthesis in rat liver. (1966) (74)
- Role of uridine phosphorylase in the anabolism of 5-fluorouracil. (1985) (69)
- Fatty livers induced by orotic acid. I. Accumulation and metabolism of lipids. (1961) (67)
- Studies on the Carcinostatic Activity in Mice of 6-Azauracil Riboside (Azauridine), In Comparison with that of 6-Azauracil ‡ (1957) (65)
- Expression, characterization, and detection of human uridine phosphorylase and identification of variant uridine phosphorolytic activity in selected human tumors. (1998) (64)
- 5-Diazo-4-Oxo-L-Norvaline: Reactive Asparagine Analog with Biological Specificity (1968) (64)
- Orotidylic acid decarboxylase: inhibition studies with azauridine 5'-phosphate. (1960) (63)
- Toxoplasma gondii tachyzoites possess an unusual plasma membrane adenosine transporter. (1995) (62)
- Cyclophilin-40: evidence for a dimeric complex with hsp90. (1995) (62)
- Clinical and pharmacological studies with 2',3',5'-triacetyl-6-azauridine. (1963) (62)
- BIOCHEMICAL AND NUTRITIONAL STUDIES ON THE INDUCTION OF FATTY LIVERS BY DIETARY OROTIC ACID. (1960) (61)
- Isolation, cDNA sequences, and biochemical characterization of the major cyclosporin-binding proteins of Toxoplasma gondii. (1994) (60)
- Summary of current information on 6-azauridine. (1962) (59)
- CYCLOPHILIN, A PRIMARY MOLECULAR TARGET FOR CYCLOSPORINE (1988) (58)
- Pyrazofurin metabolism, enzyme inhibition, and resistance in L5178Y cells. (1979) (57)
- Studies of bacterial resistance to 6-azauracil and its riboside. (1957) (56)
- Specific interaction of the cyclophilin-cyclosporin complex with the B subunit of calcineurin. (1993) (54)
- Alterations in pyrimidine metabolism in L5178Y leukemia cells resistant to 6-azauridine. (1961) (54)
- Microbial studies of 6-azauracil, an antagonist of uracil. (1956) (52)
- Fluoroolefin peptide isosteres - tools for controlling peptide conformations (1994) (50)
- CHAPTER 39 – Agents Which Influence Nucleic Acid Metabolism (1960) (48)
- Defective facilitated diffusion of nucleosides, a primary mechanism of resistance to 5-fluoro-2'-deoxyuridine in the HCT-8 human carcinoma line. (1985) (47)
- Enhancement of anthracycline growth inhibition in parent and multidrug-resistant Chinese hamster ovary cells by cyclosporin A and its analogues. (1989) (47)
- Induction of the differentiation of HL-60 cells by phorbol 12-myristate 13-acetate activates a Na(+)-dependent uridine-transport system. Involvement of protein kinase C. (1991) (46)
- Selective antagonism of 5-fluorouracil cytotoxicity by 4-hydroxypyrazolopyrimidine (allopurinol) in vitro. (1979) (45)
- Allopurinol modification of the toxicity and antitumor activity of 5-fluorouracil. (1980) (44)
- Serum Haptoglobin in Patients with Ovarian Malignancies (1971) (43)
- Calmodulin, cyclophilin, and cyclosporin A. (1986) (43)
- Alterations in human pyrimidine metabolism as a result of therapy with 6-azauridine. (1961) (43)
- Identification of two calcineurin B-binding proteins: tubulin and heat shock protein 60. (2002) (42)
- Phase I clinical and pharmacological studies of benzylacyclouridine, a uridine phosphorylase inhibitor. (1998) (39)
- The immunochemical distribution of cyclophilin in normal mammalian tissues. (1991) (39)
- Kinetics of N-(phosphonacetyl)-L-aspartate and pyrazofurin depletion of pyrimidine ribonucleotide and deoxyribonucleotide pools and their relationship to nucleic acid synthesis in intact and permeabilized cells. (1982) (39)
- Aberrant cell cycle inhibition pattern in human colon carcinoma cell lines after exposure to 5-fluorouracil. (1995) (36)
- The relationship between the penetration of tryptamine and 5-hydroxytryptamine into smooth muscle and the associated contractions. (1967) (33)
- Enhancement of fluorouracil therapy by the manipulation of tissue uridine pools. (1989) (33)
- Nonspecific "lymphocyte activating" factors produced by macrophages. (1979) (32)
- AN ANALYSIS OF THE LACK OF DRUG SYNERGISM DURING SEQUENTIAL BLOCKADE OF DE NOVO PYRIMIDINE BIOSYNTHESIS. (1964) (32)
- Control of purine biosynthesis de novo by orotic acid in vivo and in vitro. (1968) (31)
- Inhibition of the synthesis of deoxyribonucleic acid in bacteria by 6-(p-hydroxyphenylazo)-2,4-dihydroxypyrimidine. I. Metabolic studies in Streptococcus fecalis. (1966) (31)
- A synopsis of recent investigations of 6-azauridine (NSC-32074). (1960) (30)
- Studies on the pharmacology of 6-azauracil. (1960) (29)
- PATHOGENESIS OF OROTIC ACID-INDUCED FATTY CHANGE IN THE RAT LIVER: LIGHT AND ELECTRON MICROSCOPIC STUDIES. (1965) (28)
- 5-azaorotic acid and related inhibitors of the synthesis de novo of pyrimidine nucleotides. (1963) (27)
- Structure of peptide from active site region of Escherichia coli L-asparaginase. (1977) (26)
- Expression of human cyclophilin-40 and the effect of the His141-->Trp mutation on catalysis and cyclosporin A binding. (1995) (24)
- Brequinar potentiates 5-fluorouracil antitumor activity in a murine model colon 38 tumor by tissue-specific modulation of uridine nucleotide pools. (1992) (24)
- A method for the purification of coenzyme A from yeast. (1953) (24)
- A METHOD FOR PURIFICATION OF COENZYME A (1952) (22)
- Peptidyl-prolyl cis-trans isomerase activity of cyclophilin studied by one-dimensional proton nuclear magnetic resonance spectroscopy (1990) (22)
- Differentiation of HL-60 cells by dimethylsulfoxide activates a Na(+)-dependent nucleoside transport system. (1994) (21)
- Cyclophilin, a primary molecular target for cyclosporine. Structural and functional implications. (1988) (21)
- Benzylacyclouridine. Pharmacokinetics, metabolism and biochemical effects in mice. (1988) (20)
- 1H NMR studies on bovine cyclophilin: preliminary structural characterization of this specific cyclosporin A binding protein. (1986) (20)
- The rate of mutation of L5178Y asparagine-dependent mouse leukemia cells to asparagine independence and its biological consequences. (1973) (20)
- Bradykinin and its Gly6 analogue are substrates of cyclophilin: a fluorine-19 magnetization transfer study. (1990) (20)
- Effect of clinically modeled regimens on the growth response and development of resistance in human colon carcinoma cell lines. (1995) (19)
- Activity of cyclosporin A and a non-immunosuppressive cyclosporin against multidrug resistant leukemic cell lines. (1989) (19)
- Inactivation and resynthesis of glucosamine-6-phosphate synthetase after treatment with glutamine analogs. (1969) (19)
- Isolation and partial characterization of membrane-associated cyclophilin and a related 22-kDa glycoprotein. (1992) (17)
- The Stability of Coenzyme A1 (1954) (17)
- Pharmacokinetic and phase I trial of intraperitoneal carboplatin and cyclosporine in refractory ovarian cancer patients. (1997) (17)
- An improved enzymatic assay for coenzyme A. (1951) (16)
- Hepatic homeostasis of plasma L-asparagine. (1971) (16)
- L5178Y asparagine-dependent cells and independent clonal sublines. Toxicity of 5-diazo-4-oxo-L-norvaline. (1971) (16)
- Genomic structure, chromosomal mapping, and promoter region analysis of murine uridine phosphorylase gene. (1999) (16)
- 1H NMR studies on bovine cyclophilin: preliminary structural characterization of its complex with cyclosporin A. (1990) (16)
- Structural elements pertinent to the interaction of cyclosporin A with its specific receptor protein, cyclophilin. (1990) (15)
- Tissue-specific expansion of uridine pools in mice. Effects of benzylacyclouridine, dipyridamole and exogenous uridine. (1991) (15)
- Effects of asparagine synthetase inhibitors on asparaginase resistant tumors. (1977) (14)
- HIV protease substrate conformation: modulation by cyclophilin A (1997) (14)
- Inhibition by pertussis toxin of the activation of Na(+)-dependent uridine transport in dimethyl-sulphoxide-induced HL-60 leukaemia cells. (1991) (14)
- Cyclophilin binding: a receptor-mediated approach to monitoring cyclosporine immunosuppressive activity following organ transplantation. (1990) (14)
- New asparagine analogs. (1973) (14)
- Regulation of the nuclear factor of activated T cells in stably transfected Jurkat cell clones. (1996) (14)
- Enzymatic and nutritional evidence for two-stage exression of the asparagine synthetase locus in L5178y murine leukemia mutants. (1974) (14)
- Conference on obstacles to the control of acute leukemia. Formal discussion: some enzymatic considerations in combination chemotherapy. (1965) (13)
- Production of L-asparagine by tumor cells and the effect of asparagine analogs. (1972) (13)
- Renal tubular excretion studies with pyrimidine derivatives and analogs. (1962) (13)
- Discrete roles of hepatocytes and nonparenchymal cells in uridine catabolism as a component of its homeostasis. (1998) (13)
- Metabolic and biochemical effects of 6-azacytidine in mice with Ehrlich ascites carcinoma (1963) (12)
- β-Alanine and α-fluoro-β-alanine concentrative transport in rat hepatocytes is mediated by GABA transporter GAT-2. (1999) (12)
- Clinical, biological, and biochemical effect of pyrazofurin. (1978) (11)
- Pharmacological and clinical studies with triacetyl 6-azauridine. (1962) (11)
- Effects of uridine on the growth and differentiation of HL-60 leukemia cells. (1991) (11)
- Bacterial Preparation of Orotidine-5′-phosphate and Uridine-5′-phosphate (1958) (11)
- Hepatic regulation of plasma L-asparagine. (1973) (10)
- Nitroasparaginase. Subunit cross-linkage and altered substrate specificity. (1972) (10)
- Uridine Phosphorylase Association with Vimentin (2001) (10)
- Preparation and purification of coenzyme A concentrates. (1951) (9)
- Characterization of lymphocyte activating factor from mouse tumor cell lines and human leukocytes (1976) (9)
- Highly selective drug combinations for human colon cancer cells resistant in vitro to 5-fluoro-2'-deoxyuridine. (1985) (9)
- Modification of L-asparaginase by subunit cross-linking with dimethylsuberimidate. (1972) (9)
- beta-alanine and alpha-fluoro-beta-alanine concentrative transport in rat hepatocytes is mediated by GABA transporter GAT-2. (1999) (9)
- Abortifacient and teratogenic effects of triacetyl-6-azauridine in the monkey. (1970) (8)
- Cyclosporine--mechanism of action. (1988) (8)
- Purification and properties of orotidylate decarboxylases from yeast and rat liver. (1961) (8)
- Hepatic and biliary transport of orotate and its metabolic consequences. (1979) (8)
- Concentration of bound pantothenic acid. (1950) (8)
- Tissue-specific enhancement of uridine utilization and 5-fluorouracil therapy in mice by benzylacyclouridine. (1985) (8)
- Modulation of doxorubicin dox resistance by cyclosporin a csa and a non immunosuppressive homolog (1987) (7)
- Altered plasma kinetics of 5-FU at high dosage in rat and man. (1985) (7)
- The interaction between lysozyme and penicillin. (1967) (7)
- ISOLATION AND CHARACTERIZATION OF LOW DENSITY STRUCTURES FROM OROTIC ACID-INDUCED FATTY LIVERS (1969) (7)
- The influence of certain antimetabolites on the incorporation of orotic acid into pseudouridine in animals. (1963) (7)
- Investigation of l-asparagine metabolism in animals and human sub- jects. Abstr. (1968) (7)
- Immunity, microbial pathogenesis, and immunophilins: finding the keys, now where are the locks? (1992) (6)
- Correction: Uptake and Nature of the Intracellular Binding of Cyclosporin A in a Murine Thymoma Cell Line, BW5147 (1984) (5)
- Azauracil ribonucleoside and ribonucleotides: isolation and chemical synthesis. (1960) (5)
- Nonspecific "lymphocyte activating" factors produced by macrophages. (1979) (5)
- Physical and biological properties of acetamidino-, beta-dimethylaminopropionamidino-, and maleyl-L-asparaginase. (1973) (5)
- Cyclophilin binding: a more accurate measure of cyclosporine immunosuppressive activity after renal transplantation. (1991) (5)
- Concentrative transport of adenosine in murine splenocytes: limitation by an ecto-adenosine deaminase. (1995) (4)
- The active site of L-asparaginase: dimethylsulfoxide effect of 5-diazo-4-oxo-L-norvaline interactions. (1976) (4)
- Synthesis of model compounds relevant to the active-site-directed inactivation of L-asparaginase by 5-diazo-4-oxo-L-norvaline. (2009) (4)
- Effects of n-(phosphonacetyl)-l-aspartate (pala) on circulating pyrimidine nucleosides, nucleotide pools, and nucleic acid synthesis. Abstr. (1980) (4)
- METHODS FOR DETERMINATION OF PERMEABILITY OF CELLS TO DRUGS. (1964) (3)
- Effect of herpes simplex virus type 1 infection on nucleoside transport in HeLa S3 cells. (1990) (3)
- Aspects of pharmacology pertinent to the skin (1974) (3)
- The decarboxylation of 5‐azaorotic acid (1967) (3)
- Nonspecific "lymphocyte activating" factors produced by macrophages. (1979) (3)
- Symposium on estrogen receptor determination with monoclonal antibodies. Monte Carlo, December 14, 1984. (1986) (3)
- Discrete roles of hepatocytes and nonparenchymal cells in uridine catabolism as a component of its homeostasis. (1998) (2)
- Two different metabolic fates of 5-ethyl-6-azauracil in mice. (1963) (2)
- A Small-Angle X-ray Scattering Study of the Binding of Cyclosporin A to Cyclophilin (1995) (2)
- Structural and regulatory aspects of enzymes in chemotherapy. (1969) (2)
- Asparaginase. Stereochemistry of the active center as determined by circular dichroism of substrates. (1973) (2)
- Fluoroolefin Peptide Isosteres - Tools for Controlling Peptide Conformations. (1995) (2)
- Some considerations in the design of new antineoplastic agents (1977) (2)
- Antagonism of 5-fluorouracil (5fu) growth inhibition and toxicity by allopurinol (al) and pyrazofurin (pf). Abstr. (1978) (1)
- NMR methods for elucidating macromolecule-ligand interactions: an approach to drug design. Proceedings of the Fourth Biochemical Pharmacology Symposium. New Haven, CT, 27-29 July 1989. (1990) (1)
- NMR methods for elucidating macromolecule-ligand interactions: an approach to drug design. Proceedings of the Fourth Biochemical Pharmacology Symposium. New Haven, CT, 27-29 July 1989. (1990) (1)
- NEW ASPARAGINE ANALOGS (1974) (1)
- Convenient method for preparation of coenzyme (1952) (1)
- Active site of L-asparaginase: reaction with diazo-4-oxonorvaline. (1977) (1)
- Kinetic mechanism of l-asparagine synthetase of 6c3hed-rg1 tumor. Abstr. (1970) (1)
- Alternative protein ligands of calcineurin b: Ca++dependent interaction with tubulin and heat shock protein 60 (1996) (1)
- The possible role of laf as a physiological mediator in the immune response. Abstr. (1975) (1)
- Enzymatic formation of uracil and azauriail nucleotides in Streptococcus faecalis. (1966) (1)
- An overview of recent progress in ligand-receptor research based on nuclear magnetic resonance spectroscopy. (1990) (1)
- Tamoxifen induces Na+ -dependent uridine transport and dome formation in a human breast tumor cell line. (1995) (0)
- Some Principles of Energetics in Biochemical Reactions (1957) (0)
- Examination of the action of cyclosporin a (cya) on a malignant t cell line, bw5147. Abstr. (1982) (0)
- Tumor cell lysis by disruption of sulfhydryl-disulfide equilibra. Abstr. (1975) (0)
- Experimental Chemotherapy (1963) (0)
- Two-dimensional /sup 1/H NMR studies on cyclophilin, a cytosolic cyclosporin A binding protein (1986) (0)
- Allopurinol Modificationof the Toxicityand AntitumorActivityof 5-Fluorouracil' (1980) (0)
- Cyclophilin represents a novel class of protein kinases (1987) (0)
- Orotidylic Acid Decarboxylase: Inhibition Studies (2003) (0)
- Analysis of t cell ontogeny in mitogenized thymocyte populations by cyclosporin a. Abstr. (1979) (0)
- Evaluation of L†̃AsparagineMetabolism L†̃AsparagineMetabolism L†̃AsparagineMetabolism in Animals and Man ' (2006) (0)
- Comparison of the metabolism and biochemical effects of 6-azacytidine (azcr) and 6-azauridine (azur). Abstr. (1963) (0)
- AND L-ASP ARAGINE MET ABOLISM1 (1970) (0)
- Phosphorolytic Activity in Selected Human Tumors Phosphorylase and Identification of Variant Uridine Expression , Characterization , and Detection of Human Uridine Updated (2006) (0)
- SOME CONSEQUENCES OF INHIBITION OF THE DE NOVO PATHWAY OF PYRIMIDINE BIOSYNTHESIS (1979) (0)
- Augmentation of doxorubicin and 4' epidoxorubicin in parental and multidrug-resistant chinese hamster ovary cell lines by cyclosporin A and its nonimmunosuppressive homologs (1989) (0)
- Riboside of 1,2,4-triazine-3,5(2H, 4H)-dione (I; R=H) (6-azauracil), which interupts pyrimidine nucleoside formation by inhibition of orotydylic acid decarboxylase through conversion to its 5'-monophosphate6) in some mutant of microorganisms7,8) or mam- (2010) (0)
- Differential actions of oxonate and oxaidin on pyrimidine metabolism in livers and tumors. Abstr. (1962) (0)
- DETERMINATION OF ALTERATIONS IN METABOLISM OF PYRIMIDINES AND THEIR ANALOGS. (1964) (0)
- Cancer chemotherapy: examples of current progress and future perspectives (1984) (0)
- PYRIMIDINE METABOLISM AS A TARGET FOR CHEMOTHERAPY (1968) (0)
- Cyclosporin a inhibition of normal and malignant thymus derived cell lines (1980) (0)
- Region Analysis of Murine Uridine Phosphorylase Gene Genomic Structure , Chromosomal Mapping , and Promoter Updated (1999) (0)
- OXONATE AND OTHER RELATED ANTIMETABOLITES OF THE SYNTHESIS DE NOVO OF PYRIMIDINE NUCLEOTIDES. (1964) (0)
This paper list is powered by the following services:
What Schools Are Affiliated With Robert E. Handschumacher?
Robert E. Handschumacher is affiliated with the following schools: