Richard Alan John. Knowles
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Richard Alan John. Knowlesphilosophy Degrees
Philosophy
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#12004
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Logic
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#7039
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Richard Alan John. Knowlesbiology Degrees
Biology
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#15076
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Molecular Biology
#1823
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#1852
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Biochemistry
#1946
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#2087
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Philosophy Biology
Richard Alan John. Knowles's Degrees
- PhD Biochemistry University of California, Berkeley
- Doctorate Medicine University of California, San Francisco
Why Is Richard Alan John. Knowles Influential?
(Suggest an Edit or Addition)Richard Alan John. Knowles's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Nitric oxide synthases in mammals. (1994) (2787)
- Nitric oxide synthases: structure, function and inhibition. (2001) (2747)
- Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase. (1989) (1420)
- Nitric oxide synthases: structure, function and inhibition (2001) (1372)
- Induction of calcium-dependent nitric oxide synthases by sex hormones. (1994) (1101)
- 1400W Is a Slow, Tight Binding, and Highly Selective Inhibitor of Inducible Nitric-oxide Synthase in Vitro and in Vivo* (1997) (837)
- Widespread tissue distribution, species distribution and changes in activity of Ca2+‐dependent and Ca2+‐independent nitric oxide synthases (1991) (651)
- Nitric oxide synthase activity in human breast cancer. (1995) (640)
- Nitric oxide synthase activity in human gynecological cancer. (1994) (443)
- Anti-inflammatory glucocorticoids inhibit the induction by endotoxin of nitric oxide synthase in the lung, liver and aorta of the rat. (1990) (411)
- Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat. (1990) (401)
- Nitric oxide and peroxynitrite exert distinct effects on mitochondrial respiration which are differentially blocked by glutathione or glucose. (1996) (324)
- Nitric oxide as a signal in blood vessels. (1992) (294)
- Nitric oxide synthases. (1996) (286)
- Constitutive and inducible nitric oxide synthases incorporate molecular oxygen into both nitric oxide and citrulline. (1991) (282)
- Nitric oxide from L-arginine stimulates the soluble guanylate cyclase in adrenal glands. (1989) (250)
- Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: studies with 1400W, a novel inhibitor. (1997) (204)
- The formation of nitric oxide donors from peroxynitrite (1995) (195)
- Potent and selective inhibition of human nitric oxide synthases. Selective inhibition of neuronal nitric oxide synthase by S-methyl-L-thiocitrulline and S-ethyl-L-thiocitrulline. (1994) (191)
- Metabolic control. (1994) (173)
- Induction of nitric oxide synthases early in pregnancy. (1994) (170)
- Kinetic characteristics of nitric oxide synthase from rat brain. (1990) (149)
- Selective inducible nitric oxide synthase inhibition has no effect on allergen challenge in asthma. (2007) (134)
- GW274150, a novel and highly selective inhibitor of the inducible isoform of nitric oxide synthase (iNOS), shows analgesic effects in rat models of inflammatory and neuropathic pain (2006) (133)
- Quantification of the importance of individual steps in the control of aromatic amino acid metabolism. (1986) (129)
- Suppression of acute experimental colitis by a highly selective inducible nitric-oxide synthase inhibitor, N-[3-(aminomethyl)benzyl]acetamidine. (2001) (115)
- The role of nitric oxide in osteoarthritis (2007) (113)
- In Vitro Pharmacological Characterization of Vilanterol, a Novel Long-Acting β2-Adrenoceptor Agonist with 24-Hour Duration of Action (2013) (100)
- Synthesis of nitric oxide in the bovine retina. (1991) (100)
- THE role of indoleamine 2,3‐dioxygenase in the anti‐tumour activity of human interferon‐γ in vivo (1995) (97)
- “T2-high” in severe asthma related to blood eosinophil, exhaled nitric oxide and serum periostin (2019) (95)
- Inhibition of iNOS activity by 1400W decreases glutamate release and ameliorates stroke outcome after experimental ischemia (2005) (93)
- GW274150 and GW273629 are potent and highly selective inhibitors of inducible nitric oxide synthase in vitro and in vivo (2005) (85)
- Inhibition of hepatic gluconeogenesis by nitric oxide: a comparison with endotoxic shock. (1994) (84)
- Measurement of NOS activity by conversion of radiolabeled arginine to citrulline using ion-exchange separation. (1998) (80)
- The Ontogeny of Cerebral and Cerebellar Nitric Oxide Synthase in the Guinea Pig and Rat (1996) (76)
- Inhibition of inducible nitric oxide synthase by acetamidine derivatives of hetero-substituted lysine and homolysine. (2000) (69)
- Nitric oxide biochemistry. (1997) (67)
- How does displacement of albumin-bound tryptophan cause sustained increases in the free tryptophan concentration in plasma and 5-hydroxytryptamine synthesis in brain? (1989) (64)
- Identification and Characterization of PDE4A11, a Novel, Widely Expressed Long Isoform Encoded by the Human PDE4A cAMP Phosphodiesterase Gene (2005) (63)
- Transport of the aromatic amino acids into isolated rat liver cells. Properties of uptake by two distinct systems. (1986) (59)
- GSK256066, an Exceptionally High-Affinity and Selective Inhibitor of Phosphodiesterase 4 Suitable for Administration by Inhalation: In Vitro, Kinetic, and In Vivo Characterization (2011) (58)
- Assay of NOS activity by the measurement of conversion of oxyhemoglobin to methemoglobin by NO. (1998) (56)
- Inhibition by Lamotrigine of the Generation of Nitric Oxide in Rat Forebrain Slices (1995) (53)
- Regulation of the nitric oxide production resulting from the glucocorticoid-insensitive expression of iNOS in human osteoarthritic cartilage. (2001) (51)
- In Vivo Characterization of GSK256066, a High-Affinity Inhaled Phosphodiesterase 4 Inhibitor (2011) (47)
- Selective iNOS inhibitor 1400W enhances anti-catabolic IL-10 and reduces destructive MMP-10 in OA cartilage. Survey of the effects of 1400W on inflammatory mediators produced by OA cartilage as detected by protein antibody array. (2008) (46)
- Bi-directional effects of the elevation of intracellular calcium on the expression of inducible nitric oxide synthase in J774 macrophages exposed to low and to high concentrations of endotoxin. (2001) (45)
- Pregnancy increases guanosine 3',5'-monophosphate in the myometrium independent of nitric oxide synthesis. (1994) (43)
- House dust mite induces direct airway inflammation in vivo: implications for future disease therapy? (2009) (41)
- A simple method for purification of epoxide hydratase from rat liver. (1977) (39)
- Urinary Leukotriene E4 and Prostaglandin D2 Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type 2 Inflammation. A Clinical Observational Study (2020) (36)
- Antitumor Activity of γ-Interferon in Ascitic and Solid Tumor Models of Human Ovarian Cancer (1991) (36)
- Myometrial arginase activity increases with advancing pregnancy in the guinea pig. (1996) (34)
- A quantitative analysis of the control of glutamine catabolism in rat liver cells. Use of selective inhibitors. (1993) (33)
- The control of aromatic amino acid catabolism and its relationship to neurotransmitter amine synthesis. (1989) (27)
- Plasma nitrate clearance in mice: modeling of the systemic production of nitrate following the induction of nitric oxide synthesis (2004) (27)
- Enhancers of nonspecific immunity induce nitric oxide synthase: Induction does not correlate with toxicity or adjuvancy (1992) (26)
- The characteristics and site of inhibition of gluconeogenesis in rat liver cells by bacterial endotoxin. Stimulation of phosphofructokinase-1. (1987) (25)
- No detectable NO synthesis from l‐arginine or N G‐hydroxy‐l‐arginine in fMLP‐stimulated human blood neutrophils despite production of nitrite, nitrate, and citrulline from N G‐hydroxy‐l‐arginine (1999) (25)
- A comparison of antiasthma drugs between acute and chronic ovalbumin-challenged guinea-pig models of asthma. (2012) (25)
- A Sensitive Radiometric Assay for Tryptophan Hydroxylase Applicable to Crude Extracts (1983) (25)
- Factors affecting the DNA damaging activity of superoxide and nitric oxide. (1998) (24)
- The Identification of a Novel Phosphodiesterase 4 Inhibitor, 1-Ethyl-5-{5-[(4-methyl-1-piperazinyl)methyl]-1,3,4-oxadiazol-2-yl}-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (EPPA-1), with Improved Therapeutic Index using Pica Feeding in Rats as a Measure of Emetogenicity (2009) (23)
- Exhaled volatile organic compounds as markers for medication use in asthma (2019) (23)
- Persistent induction of nitric oxide synthase in tumours from mice treated with the anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid. (1998) (22)
- Expression of human nitric oxide synthase isozymes. (1996) (21)
- Endotoxin causes reciprocal changes in hepatic nitric oxide synthesis, gluconeogenesis, and flux through phosphoenolpyruvate carboxykinase. (1994) (21)
- Responsiveness to oral prednisolone in severe asthma is related to the degree of eosinophilic airway inflammation (2017) (21)
- Leukotriene B4 levels in sputum from asthma patients (2016) (21)
- 3-Morpholino-sydnonimine-induced suppression of human neutrophil degranulation is not mediated by cyclic GMP, nitric oxide or peroxynitrite: inhibition of the increase in intracellular free calcium concentration by N-morpholino-iminoacetonitrile, a metabolite of 3-morpholino-sydnonimine. (1997) (21)
- Use of the Comet assay to investigate the role of superoxide in glutathione-induced DNA damage. (1998) (19)
- Models of respiratory disease symposium (2013) (17)
- Inducible nitric oxide synthase is involved in the mechanisms of cocaine enhanced neuronal apoptosis induced by HIV-1 gp120 in the neocortex of rat. (2004) (17)
- AsthmaMap: An expert‐driven computational representation of disease mechanisms (2018) (17)
- Characteristics of Tryptophan Accumulation by Isolated Rat Forebrain Synaptosomes (1984) (16)
- The roles of glucagon, insulin and glucocorticoid hormones in the effects of sublethal doses of endotoxin on glucose homeostasis in rats. (1986) (16)
- Effect of treatment in vivo of rats with bacterial endotoxin on fructose 2,6-bisphosphate metabolism and L-pyruvate kinase activity and flux in isolated liver cells. (1992) (16)
- Nitrovasodilators have proliferative as well as antiproliferative effects (1991) (15)
- A microtiter-plate assay of nitric oxide synthase activity (1999) (14)
- Uptake of acetaminophen (paracetamol) by isolated rat liver cells. (1993) (13)
- Tryptophan Uptake and Hydroxylation in Rat Forebrain Synaptosomes (1984) (13)
- Development of anti-inflammatory drugs - the research and development process. (2014) (12)
- Inhibitors of nitric oxide synthase. (1998) (12)
- Mechanism of inhibition of hepatic gluconeogenesis by bacterial endotoxin: a role for nitric oxide? (1995) (10)
- Comparison of hepatic epoxide hydratase from different species: purification and immunochemical properties. (1979) (9)
- y+ LAT-1 mediates transport of the potent and selective iNOS inhibitor, GW274150, in control J774 macrophages (2006) (9)
- Light rail and the London underground (2008) (8)
- Illusions of grandeur: Mosley, fascism and British society, 1931–1981 (1988) (8)
- Mouse liver epoxide hydratase: purification and identity with the rat liver enzyme [proceedings]. (1977) (7)
- The role of tryptophan and kynurenine transport in the catabolism of tryptophan through indoleamine 2,3-dioxygenase. (1991) (7)
- GW273629 is a highly selective, short-acting iNOS (NOS-2) inhibitor both in vitro and in vivo: beneficial effects in endotoxin shock (2000) (7)
- Effects of tryptophan 2,3-dioxygenase inhibitors in the rat. (1991) (7)
- Control of phenylalanine and tyrosine metabolism by phosphorylation mechanisms. (1986) (7)
- A microtiter-plate assay of human NOS isoforms. (1998) (7)
- Transport of the aromatic amino acids into isolated rat liver cells by a ‘T’ system (1985) (6)
- A Topological Data Analysis Network Model of Asthma Based on Blood Gene Expression Profiles (2019) (5)
- Tryptophan degradation and indoleamine 2,3-dioxygenase in MRC-5 fibroblasts (1989) (5)
- Predictors and associations of the persistent airflow limitation phenotype in asthma: a post-hoc analysis of the ATLANTIS study. (2022) (5)
- Measurement of glucuronidation by isolated rat liver cells using [14C]fructose. (1992) (5)
- Antitumor activity of gamma-interferon in ascitic and solid tumor models of human ovarian cancer. (1991) (5)
- Medication adherence in patients with severe asthma prescribed oral corticosteroids in the U-BIOPRED cohort. (2021) (4)
- Application of Control Analysis to the Study of Amino Acid Metabolism (1990) (3)
- Flux Control Coefficients of Glycinamide Ribonucleotide Transformylase for de novo Purine Biosynthesis (1990) (3)
- Measures of adherence in patients with severe asthma prescribed systemic steroids in the U-BIOPRED cohort (2018) (3)
- Quantitative studies of sulphate conjugation by isolated rat liver cells using [35S]sulphate. (1991) (3)
- Regulation of hepatic aromatic amino acid metabolism. (1986) (3)
- Heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase; the identification of (2R)-2-pyrrolidinecarboxamidine as a potent and selective haem-co-ordinating inhibitor. (2011) (2)
- 7-aminoalkyl-2-amino-1,2,3,4-tetrahydro-2-naphthoic acids as inhibitors of tryptophan uptake (1992) (2)
- Bacterial endotoxin effects on carbohydrate utilization and transport (2009) (2)
- The Nature of the Kurloff Body : A Stage in the Development of the Eosinophile Leucocyte. (2)
- Challenges for the development of new treatments for severe asthma: a pharmaceutical perspective. (2011) (2)
- Nitric Oxide Synthase Inhibitors into the Clinic at Last. (2020) (2)
- Binding of 125I-labelled vasopressin to isolated rat hepatocytes. (1981) (1)
- Weighted Gene Co-expression Network Analysis of blood paediatric samples from the U-BIOPRED study identifies oxidative stress association with asthma severity (2018) (1)
- Selective INOS inhibition has no effect on allergen chalenge in Asthma (2007) (1)
- Late Breaking Abstract - Matrix metalloproteinases in serum and sputum reflect distinct processes of relevance to asthma (2019) (1)
- Does nitric oxide mediate the inhibitory effects of bacterial endotoxin on hepatic gluconeogenesis? (1993) (1)
- Symmetric and asymmetric dimethylarginine inhibit arginine transport and nitric oxide synthesis in J774 macrophages (1996) (1)
- Evidence for a non-β2-adrenoceptor (β2AR) binding site in human lung tissue for the long acting β2-agonist (LABA) vilanterol (2012) (1)
- Topological data analysis (TDA) of U-BIOPRED paediatric peripheral blood gene expression identified asthma phenotypes characterised by alternative splicing of glucocorticoid receptor (GR) mRNA (2018) (1)
- Longitudinal characterisation of a model of chronic allergic lung inflammation in mice using imaging, functional and immunological methods (2013) (1)
- Endotoxin causes reciprocal changes in hepatic nitric oxide synthesis and gluconeogenesis. (1995) (1)
- Metabolic control analysis of purine biosynthesis from serine in Molt-4 cells. (1996) (1)
- Kinetics of nitric oxide synthase: a reply (1990) (1)
- Inhibitors of enzymes (1995) (1)
- 21 – Gluconeogenesis in Liver Cells (1994) (1)
- Effect of endotoxin on fructose 2,6-bisphosphate in isolated hepatocytes. (1990) (0)
- Compositions pharmaceutiques contenant des inhibiteurs de synthase d'oxyde nitrique ainsi que des agents anticancereux (1994) (0)
- Derives de pyrimidine, de pyridine, de pteridinone et d'indazole utilises comme inhibiteurs enzymatiques (1993) (0)
- 1 Introducing Transport Geographies (2007) (0)
- Nitric oxide synthases in mammals 251 OCH 3 H 2 NNH (2005) (0)
- The short term hormonal control of cytoplasmic protein phosphorylation in hepatocytes from fed rats. (1983) (0)
- Contents (2020) (0)
- Alternative Traffic Signal Illumination (1998) (0)
- Thecharacteristics andsite ofinhibition ofgluconeogenesis inrat livercells bybacterial endotoxin Stimulation ofphosphofructokinase-1 (1987) (0)
- A novel, simple and rapid method to measure soluble mediators in dithiothreitol-treated sputum (2012) (0)
- Oral Communications-Contribution of non-neuronal cells to chronic pain of peripheral origin 35P C58 The inducible isoform of nitric oxide synthase (iNOS) has an important peripheral role in the development of inflammatory and neuropathic pain (2005) (0)
- The Identification of a Novel PDE 4 Inhibitor , EPPA-1 , with Improved Therapeutic Index using Pica Feeding in Rats as a Measure of (2009) (0)
- O82. Preclinical and clinical data with the selective iNOS inhibitor GW274150 (2008) (0)
- Bal Cell Lysate IL1B Synthesis And Processing Correlates With Blood Eosinophil Levels In Subjects With Asthma (2011) (0)
- Book Review: The politics of mobility. Transport, the environment and public policy (2003) (0)
- Morse-clustering of a Topological Data Analysis Network Identifies Phenotypes of Asthma Based on Blood Gene Expression Profiles (2019) (0)
- Effect ofPotato Seed-Tuber AgeonPlant Establishment andAmelioration ofAge-Linked Effects withAuxin' (1990) (0)
- GSK 256066 , An Exceptionally High Affinity and Selective Inhibitor of PDE 4 Suitable for Administration by Inhalation : In vitro , Kinetic and In vivo Characterisation (2011) (0)
- Howdoesdisplacement ofalbumin-bound tryptophan cause sustained increases inthefree tryptophan concentration inplasma and5-hydroxytryptam (1989) (0)
- Overcoming The Steroid Insensitivity Of Leukotriene B4 (LTB4) Production In Human Alveolar Macrophages: Pharmacological Inhibition Of 5-Lipoxygeanase And FLAP Enzymes (2011) (0)
- As you like it and concept of plot (1964) (0)
- Annotated Bibliography of Explosive Excavation Related Research (1972) (0)
- Nitric oxide synthase: Characterisation and functional analysis Methods in neurosciences (1997) (0)
- Health waves: The media is often criticised for its negative portrayal of mental health. Richard Knowles shows how local radio can help (1998) (0)
- Association between exhaled volatile organic compounds and urinary levels of oral corticosteroids within the U-BIOPRED Cohort (2018) (0)
- Effect of L-glutamate-gamma-hydrazide on the transport and metabolism of L-glutamine in rat liver cells and isolated mitochondria. (1990) (0)
- 1. Nitric oxide, mitochondria and cytotoxicity (2017) (0)
- Lipid phenotyping of lung epithelial lining fluid in healthy human volunteers (2018) (0)
- Determination of glucuronidation in isolated rat liver cells by incorporation of 14C from fructose. (1990) (0)
- Book Review: An historical geography of railways in Great Britain and Ireland (2001) (0)
- Quantification oftheimportance ofindividual stepsinthecontrol ofaromatic amino acid metabolism (1986) (0)
- Pyrazolo (3,4-b) pyridine compounds and their use as phosphodiesterasinhibitoren (2003) (0)
- CONTROL OF TRYPTOPHAN UTILIZATION IN LIVER CELLS (1987) (0)
- The Italian Republican Party in the "heroic" years, 1926-1948 : a case study in the failure of realignment (1983) (0)
- European transport and communications networks: Policy evolution and change: Edited by David Banister, Roberta Capello and Peter Nijkamp Wiley Chichester (1995) 348 pp £40.00 hardback (1997) (0)
- Determination of sulphate conjugation in isolated rat liver cells by incorporation of 35S-labelled inorganic sulphate. (1990) (0)
- Utilisation d'inhibiteurs de synthase du monoxyde d'azote dans la fabrication d'un medicament destine a etre utilise dans la prophylaxie ou le traitement d'infections bacteriennes (1999) (0)
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What Schools Are Affiliated With Richard Alan John. Knowles?
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