R. Kip Guy
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Chemistry researcher; academic
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R. Kip Guychemistry Degrees
Chemistry
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Organic Chemistry
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#974
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Chemistry
R. Kip Guy's Degrees
- PhD Chemistry University of California, Berkeley
- Masters Chemistry University of California, Berkeley
- Bachelors Chemistry University of California, Berkeley
Why Is R. Kip Guy Influential?
(Suggest an Edit or Addition)According to Wikipedia, R. Kip Guy is an American pharmaceutical chemist. , he is the dean of the University of Kentucky College of Pharmacy. Early life and education Guy was born in Alabama but was raised in various places including Jacks Creek, Tennessee, England, and Ohio. He completed his Bachelor of Arts degree in chemistry from Reed College before working as a process development chemist in the process translation unit at IBM Research. Following this, he received his PhD in organic chemistry in 1996 based on the total synthesis of taxol from the Scripps Research Institute. His thesis was conducted under the guidance of K. C. Nicolaou and was titled An Exploration of the Chemistry of Taxol. After this, Guy accepted a postdoctoral fellowship in cellular biology at the University of Texas Southwestern Medical Center and additional training in physiology at the Woods Hole Oceanographic Institution.
R. Kip Guy's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Total synthesis of taxol (1994) (864)
- Inactivation of the p53 pathway in retinoblastoma (2006) (585)
- Chemical genetics of Plasmodium falciparum (2010) (528)
- Chemistry and Biology of Taxol (1994) (500)
- Structural Analyses Reveal Phosphatidyl Inositols as Ligands for the NR5 Orphan Receptors SF-1 and LRH-1 (2005) (392)
- Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond (2016) (324)
- High-throughput assays for promiscuous inhibitors (2005) (304)
- Quinolone-3-Diarylethers: A New Class of Antimalarial Drug (2013) (276)
- A surface on the androgen receptor that allosterically regulates coactivator binding (2007) (267)
- Rapid repurposing of drugs for COVID-19 (2020) (224)
- An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth. (2007) (208)
- MAGI-1, a Membrane-associated Guanylate Kinase with a Unique Arrangement of Protein-Protein Interaction Domains* (1997) (208)
- (+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium (2014) (200)
- Nanomolar Affinity Small Molecule Correctors of Defective ΔF508-CFTR Chloride Channel Gating* (2003) (191)
- Identification and Characterization of the First Small Molecule Inhibitor of MDMX* (2010) (189)
- Total Synthesis of Taxol. 2. Construction of A and C Ring Intermediates and Initial Attempts To Construct the ABC Ring System (1995) (162)
- The Molecular Mechanisms of Coactivator Utilization in Ligand-dependent Transactivation by the Androgen Receptor* (2005) (142)
- Scaffold composition and biological relevance of screening libraries. (2007) (136)
- Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain. (2005) (135)
- Global phenotypic screening for antimalarials. (2012) (132)
- Total Synthesis of Taxol. 1. Retrosynthesis, Degradation, and Reconstitution (1995) (132)
- Efficacy of Retinoids in IKZF1-Mutated BCR-ABL1 Acute Lymphoblastic Leukemia. (2015) (131)
- Targeting the binding function 3 (BF3) site of the human androgen receptor through virtual screening. (2011) (131)
- Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells (2011) (127)
- Searching for New Antimalarial Therapeutics amongst Known Drugs (2006) (124)
- Pemetrexed and gemcitabine as combination therapy for the treatment of Group3 medulloblastoma. (2014) (121)
- Total Synthesis of Taxol. 3. Formation of Taxol's ABC Ring Skeleton (1995) (120)
- NALP3 inflammasome up-regulation and CASP1 cleavage of the glucocorticoid receptor causes glucocorticoid resistance in leukemia cells (2015) (116)
- Reporting data from high-throughput screening of small-molecule libraries. (2007) (104)
- Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities. (2005) (102)
- An integrated in vitro and in vivo high-throughput screen identifies treatment leads for ependymoma. (2011) (101)
- Discovery of Small Molecule Inhibitors of the Interaction of the Thyroid Hormone Receptor with Transcriptional Coregulators* (2005) (93)
- Non-competitive androgen receptor inhibition in vitro and in vivo (2009) (93)
- Activity of piperaquine and other 4-aminoquinoline antiplasmodial drugs against chloroquine-sensitive and resistant blood-stages of Plasmodium falciparum. Role of beta-haematin inhibition and drug concentration in vacuolar water- and lipid-phases. (2007) (92)
- Nanomolar affinity small molecule correctors of defective Delta F508-CFTR chloride channel gating. (2003) (85)
- Novel selective inhibitors of the interaction of individual nuclear hormone receptors with a mutually shared steroid receptor coactivator 2. (2003) (84)
- Incorporation of an intramolecular hydrogen-bonding motif in the side chain of 4-aminoquinolines enhances activity against drug-resistant P. falciparum. (2006) (82)
- Discovery of Novel Antimalarial Compounds Enabled by QSAR-Based Virtual Screening (2013) (76)
- Parallel synthesis of 9-aminoacridines and their evaluation against chloroquine-resistant Plasmodium falciparum. (2006) (71)
- Anticancer Properties of Distinct Antimalarial Drug Classes (2013) (71)
- Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles (2015) (70)
- The Conquest of Taxol (1995) (70)
- Synthesis of medium ring heterocycles using an intramolecular Heck reaction. (2004) (69)
- Inhibition of a Viral Enzyme by a Small Molecule Dimer Disruptor (2009) (68)
- Inhibition of sonic hedgehog autoprocessing in cultured mammalian cells by sterol deprivation. (2000) (68)
- Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: towards a pharmacophore model for the nucleotide-binding domain. (2003) (66)
- Blocking an N-terminal acetylation–dependent protein interaction inhibits an E3 ligase (2017) (64)
- A selective irreversible inhibitor targeting a PDZ protein interaction domain. (2003) (62)
- Quantitative Proteomics of the Thyroid Hormone Receptor-Coregulator Interactions*[boxs] (2004) (62)
- Proteomimetic libraries: design, synthesis, and evaluation of p53-MDM2 interaction inhibitors. (2006) (61)
- Synthesis and testing of a focused phenothiazine library for binding to HIV-1 TAR RNA. (2006) (60)
- Quantification of the vitamin D receptor-coregulator interaction. (2009) (59)
- Parallel synthesis and antimalarial screening of a 4-aminoquinoline library. (2004) (59)
- Whole-Body Physiologically Based Pharmacokinetic Model for Nutlin-3a in Mice after Intravenous and Oral Administration (2011) (58)
- Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor. (2007) (58)
- CDK2 inhibitors as candidate therapeutics for cisplatin- and noise-induced hearing loss (2018) (56)
- Development of a new generation of 4-aminoquinoline antimalarial compounds using predictive pharmacokinetic and toxicology models. (2010) (56)
- Antimalarials in development in 2014. (2014) (54)
- Conformation of a water-soluble derivative of taxol in water by 2D-NMR spectroscopy. (1994) (53)
- Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB. (2008) (52)
- Role of electrostatic interactions in PDZ domain ligand recognition. (2003) (51)
- Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB. (2008) (51)
- An α-Helical Peptidomimetic Inhibitor of the HIV-1 Rev−RRE Interaction (2006) (50)
- A Water‐Soluble Prodrug of Taxol with Self‐Assembling Properties (1994) (48)
- Improvement of pharmacological properties of irreversible thyroid receptor coactivator binding inhibitors. (2009) (46)
- Isotopically labeled crosslinking reagents: resolution of mass degeneracy in the identification of crosslinked peptides. (2003) (45)
- Ligand-selective inhibition of the interaction of steroid receptor coactivators and estrogen receptor isoforms. (2004) (44)
- On the Mechanism of Action of SJ-172550 in Inhibiting the Interaction of MDM4 and p53 (2012) (44)
- The interdependence between screening methods and screening libraries. (2007) (44)
- UPLC-MS-ELSD-PDA as a powerful dereplication tool to facilitate compound identification from small-molecule natural product libraries. (2014) (44)
- Chemical Synthesis and Biological Evaluation of C-2 Taxoids (1995) (43)
- Progress in Small Molecule Therapeutics for the Treatment of Retinoblastoma. (2016) (42)
- Discovery of the first irreversible small molecule inhibitors of the interaction between the vitamin D receptor and coactivators. (2012) (42)
- Taxoids: new weapons against cancer. (1996) (41)
- Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships. (2007) (40)
- Repositioning: the fast track to new anti-malarial medicines? (2014) (39)
- Synthesis and evaluation of 7-substituted 4-aminoquinoline analogues for antimalarial activity. (2011) (38)
- Evaluation of Diarylureas for Activity Against Plasmodium falciparum. (2010) (38)
- Assay Optimization and Screening of RNA-Protein Interactions by AlphaScreen (2007) (38)
- Coregulator Interactions with the Thyroid Hormone Receptor (2005) (38)
- Synthesis and structure-activity relationships of antimalarial 4-oxo-3-carboxyl quinolones. (2010) (37)
- Partial acetylation of lysine residues improves intraprotein cross-linking. (2008) (36)
- Hit-to-Lead Studies for the Antimalarial Tetrahydroisoquinolone Carboxanilides. (2016) (36)
- An inhibitor of the interaction of thyroid hormone receptor beta and glucocorticoid interacting protein 1. (2001) (35)
- A High-Throughput Screening Method to Identify Small Molecule Inhibitors of Thyroid Hormone Receptor Coactivator Binding (2006) (34)
- Development of a Cell-Based, High-Throughput Screening Assay for ATM Kinase Inhibitors (2014) (34)
- Evaluation of artemisinins for the treatment of acute myeloid leukemia (2016) (33)
- Synthesis of C-2 taxol analogues (1994) (33)
- Synthesis of C-2 taxol analogues (1994) (33)
- Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation. (2018) (33)
- A novel 2'-(N-methylpyridinium acetate) prodrug of paclitaxel induces superior antitumor responses in preclinical cancer models. (2002) (33)
- Rational design of a nonpeptide general chemical scaffold for reversible inhibition of PDZ domain interactions. (2007) (32)
- Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1. (2007) (32)
- A solid-phase approach to the phallotoxins: total synthesis of [Ala7]-phalloidin. (2005) (32)
- Structure-activity relationship study of 9-aminoacridine compounds in scrapie-infected neuroblastoma cells. (2006) (32)
- Antimalarial activity of thiosemicarbazones and purine derived nitriles. (2009) (32)
- Safety, tolerability, pharmacokinetics, and antimalarial efficacy of a novel Plasmodium falciparum ATP4 inhibitor SJ733: a first-in-human and induced blood-stage malaria phase 1a/b trial. (2020) (32)
- Targeting Histone Demethylases in MYC-Driven Neuroblastomas with Ciclopirox. (2017) (31)
- Optimization of a Novel Series of Ataxia-Telangiectasia Mutated Kinase Inhibitors as Potential Radiosensitizing Agents. (2016) (31)
- Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT). (2015) (31)
- Synthesis of a fully functionalized CD ring system of taxol (1992) (31)
- Methylsulfonylnitrobenzoates, a New Class of Irreversible Inhibitors of the Interaction of the Thyroid Hormone Receptor and Its Obligate Coactivators That Functionally Antagonizes Thyroid Hormone* (2011) (30)
- A high-throughput screen indicates gemcitabine and JAK inhibitors may be useful for treating pediatric AML (2019) (29)
- Discovery of Potent and Selective Inhibitors of Trypanosoma brucei Ornithine Decarboxylase* (2010) (29)
- A novel protein crosslinking reagent for the determination of moderate resolution protein structures by mass spectrometry (MS3-D). (2004) (29)
- Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation. (2018) (27)
- Gene expression as a drug discovery tool (2004) (27)
- A metallopeptide assembly of the HIV-1 gp41 coiled coil is an ideal receptor in fluorescence detection of ligand binding. (2003) (27)
- Discovery of novel, orally bioavailable, antileishmanial compounds using phenotypic screening (2017) (27)
- Identification of Selective Inhibitors of the Plasmodium falciparum Hexose Transporter PfHT by Screening Focused Libraries of Anti-Malarial Compounds (2015) (27)
- Synthesis of Artemiside and Its Effects in Combination with Conventional Drugs against Severe Murine Malaria (2011) (26)
- Pharmacokinetics and Efficacy of the Spleen Tyrosine Kinase Inhibitor R406 after Ocular Delivery for Retinoblastoma (2014) (26)
- MDM2 antagonist nutlin-3a reverses mitoxantrone resistance by inhibiting breast cancer resistance protein mediated drug transport. (2011) (25)
- Structure-guided development of selective TbcatB inhibitors. (2009) (24)
- Screening and Development of New Inhibitors of FtsZ from M. Tuberculosis (2016) (23)
- Novel flufenamic acid analogues as inhibitors of androgen receptor mediated transcription. (2009) (22)
- Optimization of propafenone analogues as antimalarial leads. (2011) (22)
- Synthesis and evaluation of sulfonylnitrophenylthiazoles (SNPTs) as thyroid hormone receptor-coactivator interaction inhibitors. (2012) (21)
- Phenotypic Screens Reveal Posaconazole as a Rapidly Acting Amebicidal Combination Partner for Treatment of Primary Amoebic Meningoencephalitis (2018) (21)
- A High-Throughput Ligand Competition Binding Assay for the Androgen Receptor and Other Nuclear Receptors (2009) (21)
- Interaction between the androgen receptor and a segment of its corepressor SHP. (2007) (21)
- Diverse amide analogs of sulindac for cancer treatment and prevention. (2017) (20)
- Monitoring Ligand-Induced Protein Ordering in Drug Discovery. (2016) (20)
- Treatment of Murine Cerebral Malaria by Artemisone in Combination with Conventional Antimalarial Drugs: Antiplasmodial Effects and Immune Responses (2014) (19)
- Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway. (2017) (19)
- Potent Plasmodium falciparum Gametocytocidal Activity of Diaminonaphthoquinones, Lead Antimalarial Chemotypes Identified in an Antimalarial Compound Screen (2014) (18)
- An alpha-helical peptidomimetic inhibitor of the HIV-1 Rev-RRE interaction. (2006) (17)
- Flexibility is important for inhibition of the MDM2/p53 protein-protein interaction by cyclic β-hairpins. (2016) (17)
- Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors. (2018) (17)
- A Quantitative High-Throughput Screen Identifies Novel Inhibitors of the Interaction of Thyroid Receptor β with a Peptide of Steroid Receptor Coactivator 2 (2011) (17)
- Discovery of Novel Pyrazolo-Pyridone DCN1 Inhibitors Controlling Cullin Neddylation. (2019) (16)
- Bromodomain-Selective BET Inhibitors Are Potent Antitumor Agents against MYC-Driven Pediatric Cancer (2020) (16)
- Copper-mediated cross-coupling of aryl boronic acids and alkyl thiols. (2000) (15)
- Design of a selective chemical probe for class I PDZ domains. (2007) (14)
- Antimalarial activity of 10-alkyl/aryl esters and -aminoethylethers of artemisinin. (2013) (14)
- Erratum: (+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium (Proceedings of the National Academy of Sciences of the United States of America (2014) 111 (E5455-E5462) 1 DOI: 10.1073/pnas.1414221111) (2015) (14)
- Optimization of a non-radioactive high-throughput assay for decarboxylase enzymes. (2010) (14)
- A Screening-Based Approach to Circumvent Tumor Microenvironment-Driven Intrinsic Resistance to BCR-ABL+ Inhibitors in Ph+ Acute Lymphoblastic Leukemia (2014) (13)
- Seeking the Elusive Long-Acting Ozonide: Discovery of Artefenomel (OZ439). (2017) (13)
- LC-MS- and (1)H NMR Spectroscopy-Guided Identification of Antifungal Diterpenoids from Sagittaria latifolia. (2015) (13)
- Similarities and differences between two modes of antagonism of the thyroid hormone receptor. (2011) (12)
- Identification of Toll-like receptor signaling inhibitors based on selective activation of hierarchically acting signaling proteins (2018) (12)
- Optimization of chloronitrobenzamides (CNBs) as therapeutic leads for human African trypanosomiasis (HAT). (2013) (12)
- Design, Synthesis and Evaluation of 2,5-Diketopiperazines as Inhibitors of the MDM2-p53 Interaction (2015) (12)
- Investigation of the PDZ domain ligand binding site using chemically modified peptides. (2002) (12)
- Novel chemistry of taxol. Retrosynthetic and synthetic studies (1994) (12)
- Parallel synthesis of diarylureas and their evaluation as inhibitors of insulin-like growth factor receptor. (2006) (12)
- Synthesis of highly substituted dibenzo[b,f]azocines and their evaluation as protein kinase inhibitors. (2006) (11)
- Synthesis and structure-activity relationship of dual-stage antimalarial pyrazolo[3,4-b]pyridines. (2020) (11)
- Optimization of purine-nitrile TbcatB inhibitors for use in vivo and evaluation of efficacy in murine models. (2010) (10)
- Cysteine modifiers suggest an allosteric inhibitory site on the CAL PDZ domain (2018) (10)
- Performance of a docking/molecular dynamics protocol for virtual screening of nutlin-class inhibitors of Mdmx. (2017) (10)
- Optimization of the electrophile of chloronitrobenzamide leads active against Trypanosoma brucei. (2013) (10)
- Lead optimization of antimalarial propafenone analogues. (2012) (9)
- The Chemical Synthesis of C‐Ring Aryl Taxoids (2006) (9)
- An all-purpose antimalarial drug target. (2012) (9)
- Shared Consensus Machine Learning Models for Predicting Blood Stage Malaria Inhibition (2017) (9)
- Targeted Inhibition of the MLL Transcriptional Complex By Proteosome Inhibitors Elicits a High Response Rate in Relapsed/Refractory MLL Rearranged Leukemia (2014) (9)
- Discovery of a Diaminopyrimidine FLT3 Inhibitor Active against Acute Myeloid Leukemia (2017) (8)
- Dihydroquinazolinone Inhibitors of Proliferation of Blood and Liver Stage Malaria Parasites (2013) (8)
- Steroid receptor coactivator peptidomimetics. (2003) (8)
- 8-Triazolylpurines: Towards Fluorescent Inhibitors of the MDM2/p53 Interaction (2015) (7)
- Synthesis and characterization of BODIPY-labeled colchicine. (2008) (7)
- A FACILE ONE-POT SYNTHESIS OF SYMMETRICAL AND UNSYMMETRICAL ACETALDEHYDE ACETALS FROM PRIMARY ALCOHOLS (1992) (7)
- Antischistosomal versus antiandrogenic properties of aryl hydantoin Ro 13-3978. (2014) (7)
- Quinolone-3-Diarylethers : A new class of drugs for a new era of malaria eradication (2014) (7)
- Oxazole and thiazole analogs of sulindac for cancer prevention (2018) (6)
- Evaluation of 1,1-cyclopropylidene as a thioether isostere in the 4-thio-thienopyrimidine (TTP) series of antimalarials. (2020) (6)
- Erratum: A surface on the androgen receptor that allosterically regulates coactivator binding (Proceedings of the National Academy of Sciences of the United States of America (2007) 104, 41, (16074-16079) DOI: 10.1073/pnas. 0708036104) (2007) (6)
- Synthesis and evaluation of methylsulfonylnitrobenzamides (MSNBAs) as inhibitors of the thyroid hormone receptor-coactivator interaction. (2013) (6)
- Selecting an anti-malarial clinical candidate from two potent dihydroisoquinolones (2020) (6)
- An Automated Approach to Efficiently Reformat a Large Collection of Compounds (2011) (5)
- The Total Synthesis of Paclitaxel by Assembly of the Ring System (1994) (5)
- Diversity-oriented natural product platform identifies plant constituents targeting Plasmodium falciparum (2016) (5)
- Ligand competition binding assay for the androgen receptor. (2011) (5)
- Pentacyclic nitrofurans that rapidly kill nifurtimox-resistant trypanosomes. (2016) (5)
- Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway. (2019) (5)
- Antimalarial Activity of Tetrahydro-β-carbolines Targeting the ATP Binding Pocket of the Plasmodium falciparum Heat Shock 90 Protein. (2020) (5)
- A small diversity library of α-methyl amide analogs of sulindac for probing anticancer structure-activity relationships. (2018) (5)
- A Convenient Procedure for Parallel Ester Hydrolysis (2004) (5)
- Podophyllotoxin analogues active versus Trypanosoma brucei. (2010) (5)
- What is a Game (1996) (4)
- Discovery of Potent Thiosemicarbazone Inhibitors (V) of Rhodesain and Cruzain. (2005) (2)
- Correction to Targeting the Binding Function 3 (BF3) Site of the Human Androgen Receptor through Virtual Screening (2012) (2)
- Chemical Approaches to Nuclear Receptors in Metabolism (2009) (2)
- Current and emerging therapy for improving outcomes in patients with intraocular retinoblastoma (2015) (2)
- A road less traveled by: exploring a decade of Ellman chemistry. (2009) (2)
- Identification of Plasmodium falciparum Heat Shock 90 Inhibitors via Molecular Docking. (2021) (2)
- Improvement of Oral Bioavailability of Pyrazolo-Pyridone Inhibitors of the Interaction of DCN1/2 and UBE2M (2021) (2)
- Amino-Substituted 3-Aryl- and 3-Heteroarylquinolines as Potential Antileishmanial Agents (2021) (1)
- Antimalarial Activity of 2,6-Dibenzylidenecyclohexanone Derivatives. (2021) (1)
- Abstract LB-056: Discovery of novel small molecule inhibitors of the DCN1-Ubc12 interaction by high throughput screening technology (2016) (1)
- Novel Chemistry of Taxol. Retrosynthetic and Synthetic Studies. (1994) (1)
- qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 (2011) (1)
- Antimalarial constituents from a high-throughput UPLC-MS-ELSD-PDA generated natural product library (2014) (1)
- Amine Containing Analogs of Sulindac for Cancer Prevention (2018) (1)
- New Antileishmanial Drug Leads from a Library of Natural Product Fractions Prepared by a High Throughput Fractionation Paradigm (2012) (1)
- First Small Molecule Inhibitor of MDMX Identification and Characterization of the Cell Biology : (2010) (1)
- Combining SJ733, an oral ATP4 inhibitor of Plasmodium falciparum, with the pharmacokinetic enhancer cobicistat: An innovative approach in antimalarial drug development (2022) (1)
- Similarly efficacious anti-malarial drugs SJ733 and pyronaridine differ in their ability to remove circulating parasites in mice (2022) (1)
- Faculty Opinions recommendation of Surface sites for engineering allosteric control in proteins. (2008) (1)
- HIGH-THROUGHPUT SCREENING AND DRUG DISCOVERY AT ST. JUDE CHILDREN'S RESEARCH HOSPITAL (2008) (1)
- Total synthesis of Taxol. 2. construction of A and C ring intermediates and initial attempts to construct the ABC ring system. [Erratum to document cited in CA122:160984] (1995) (1)
- Repositioning: the fast track to new anti-malarial medicines? (2014) (1)
- Association between Germline Mutations in the RET Proto-Oncogene and Colorectal Cancer and Polyps (2019) (0)
- Scheme 1, [Reagents and conditions: (i) iPrNEt2, ACN, r.t. 1 h; (ii) 4, MW150°C, 10 min]. (2011) (0)
- Figure 2, Mass spectrometry analysis of TR and methylsulfonylnitrobenzoate interaction (2011) (0)
- Figure 1, TR inhibition by a methylsulfonylnitrobenzoate series member is irreversible (2011) (0)
- Table 3, Structure-activity relationships of the methylsulfonylnitrobenzoate series (2011) (0)
- Faculty Opinions recommendation of Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network. (2006) (0)
- Abstract A52: An interspecies genomics based high‐throughput screen for novel treatments of ependymoma (2009) (0)
- Figure 3, Proposed mechanism of action of methylsulfonylnitrobenzoate analogs (2011) (0)
- 72 INVITED Novel agents targeting the Wnt pathway in lung cancer (2007) (0)
- 193 The identification of new therapies for ependymoma subgroups (2014) (0)
- Identification of equal affinity MDMX/MDM2-p53 interaction small molecule inhibitors (2007) (0)
- Faculty Opinions recommendation of Resolution of chiral phosphate, phosphonate, and phosphinate esters by an enantioselective enzyme library. (2007) (0)
- Abstract 4759: Integrated in vitro and in vivo screening of tumor and normal neural stem cells identifies potential new treatments of ependymoma (2011) (0)
- Scheme 2, [Reagents and conditions: (i) iPrNEt2,...]. (2011) (0)
- Table 1, Final 1536-well assay protocol (2011) (0)
- Modeling Small Molecule‐RNA Interactions: Applications to HIV TAR RNA (2006) (0)
- Cures for neglected diseases : alternative strategies for finding drugs (2007) (0)
- PCM-22A NEW APPROACH OF PRECLINICAL TESTING OF CHEMOTHERAPIES - AN EXAMPLE OF BRAIN TUMOUR THERAPY (2016) (0)
- Ocular Delivery of the Novel Spleen Tyrosine Kinase Inhibitor R406 for Retinoblastoma (2013) (0)
- TARGETING THE BINDING FUNCTION 3 SITE OF THE ANDROGEN RECEPTOR THROUGH IN SILICO MOLECULAR MODELING (2011) (0)
- soluble onium salt of taxo-diterpenoid. (1995) (0)
- Abstract A28: The link between the metabolic effects of nuclear receptor (NR) modulators and anticarcinogenic properties on leukemia cancer cells can be revealed through studying the Warburg effect (2011) (0)
- CCDC 1045854: Experimental Crystal Structure Determination (2017) (0)
- Synthesis and evaluation of 7-substituted 4-aminoquinoline analogs for antimalarial activity (2013) (0)
- Selecting an anti-malarial clinical candidate from two potent dihydroisoquinolones (2021) (0)
- Crystal structure of the androgen receptor ligand binding domain with DHT and a peptide derived form its physiological coactivator GRIP1 NR box 2 bound in a non-helical conformation (2005) (0)
- AR LBD with small molecule (2007) (0)
- CCDC 1045853: Experimental Crystal Structure Determination (2017) (0)
- Synthesis of C‐2 Taxol Analogues. (1995) (0)
- Faculty Opinions recommendation of Chemiluminescent probe for the in vitro detection of protease activity. (2008) (0)
- crystal structure of human LRH-1 bound with TIF-2 peptide and phosphatidylglycerol (2005) (0)
- University–pharmacy partnerships for COVID-19 (2020) (0)
- Crystal structure of the second bromodomain of human BRD2 in complex with a tetrahydroquinoline inhibitor (2018) (0)
- Correction: Cysteine modification reveals an allosteric inhibitory site on the CAL PDZ domain (2018) (0)
- Pharmacokinetics and Efficacy of the Spleen Tyrosine Kinase Inhibitor R406 after Ocular Delivery for Retinoblastoma (2014) (0)
- Crystal Structure of the Androgen Receptor Ligand Binding Domain (LBD) with DHT and a peptide derived from its physiological coactivator ARA70 (2005) (0)
- Structure of DCN1 bound to NAcM-COV (2017) (0)
- Self-total taxol-diterpenoid nanostructures (1995) (0)
- Synthesis of Biologically Active Taxoids (2008) (0)
- Androgen receptor LBD with small molecule (2007) (0)
- Structure of (3S,4S)-1-benzyl-4-(3-(3-(trifluoromethyl)phenyl)ureido)piperidin-3-yl acetate bound to DCN1 (2018) (0)
- University of Dundee Diverse amide analogs of sulindac for cancer treatment and prevention (2017) (0)
- A Facile One-Pot Synthesis of Symmetrical and Unsymmetrical Acetaldehyde Acetals from Primary Alcohols. (1992) (0)
- Development and Delivery of Candidate Retinoblastoma Therapeutics (2015) (0)
- Total Synthesis of Taxol. Part 2. Construction of A and C Ring Intermediates and Initial Attempts to Construct the ABC Ring System (1995) (0)
- Structure of DCN1 bound to 3-methyl-N-((4S,5S)-3-methyl-6-oxo-1-phenyl-4-(p-tolyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl)benzamide (2019) (0)
- Open Source Drug Discovery - Highly Potent Antimalarial Compounds Derived from the GlaxoSmithKline Tres Cantos Arylpyrroles (2013) (0)
- Abstract 5389: Discovery of small molecule inhibitors of the interaction between PPARγ and SMRT (2014) (0)
- Pharmacological stabilization of ΔF508-CFTR at the cell surface: design of CAL-selective PDZ inhibitors (2010) (0)
- A Convenient Procedure for Parallel Ester Hydrolysis. (2005) (0)
- Classification of biological binding sites for large scale virtual screening of combinatorial libraries and design of general purpose organic scaffolds (2000) (0)
- Potent Plasmodium falciparum gametocytocidal activity of lead anti-malaria chemotype, (2014) (0)
- Total Synthesis of Taxol. Part 1. Retrosynthesis, Degradation, and Reconstitution. (1995) (0)
- Structure of DCN1 bound to N-((4S,5S)-7-ethyl-4-(4-fluorophenyl)-3-methyl-6-oxo-1-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl)-3-methylbenzamide (2019) (0)
- Structure of 1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-(1-propylpiperidin-4-yl)-3-(3-(trifluoromethyl)phenyl)urea bound to DCN1 (2018) (0)
- Correction for Jiménez-Díaz et al., (+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium (2015) (0)
- CCDC 1045851: Experimental Crystal Structure Determination (2017) (0)
- human Steroidogenic Factor 1 LBD with bound Co-factor Peptide (2005) (0)
- CCDC 1045852: Experimental Crystal Structure Determination (2017) (0)
- Complex Androgen Receptor LBD and RAC3 peptide (2005) (0)
- Crystal structure of the second bromodomain of human BRD2 in complex with a tetrahydroquinoline analogue (2018) (0)
- Crystal Structure of the Androgen Receptor Ligand Binding Domain with DHT and a peptide derived from its physiological coactivator GRIP1 NR box3 (2005) (0)
- Discovery of Small Molecule Inhibitors of the Interaction of the Thyroid Hormone Receptor with Transcriptional (2005) (0)
- Targeting a shared essential protein interaction interface in nuclear hormone receptor signaling pathways (2001) (0)
- Diversity-oriented natural product platform identifies plant constituents targeting Plasmodium falciparum (2016) (0)
- Integrated High-Throughput Screen to Identify Novel Treatment Leads for Pediatric Acute Myeloid Leukemia (2018) (0)
- Total Synthesis of Taxol. Part 3. Formation of Taxol′s ABC Ring Skeleton (1995) (0)
- Dereplication of antifungal compounds from small-molecule natural product libraries by LC-MS and NMR (2014) (0)
- Structure of DCN4 PONY domain bound to CUL1 WHB (2017) (0)
- Similarly efficacious anti-malarial drugs SJ733 and pyronaridine differ in their ability to remove circulating parasites in mice (2022) (0)
- Antifungal isopimaradiene diterpenoids from Sagittaria latifoli (2014) (0)
- Author Correction: Proteasome inhibition targets the KMT2A transcriptional complex in acute lymphoblastic leukemia (2023) (0)
- Proteasome inhibition targets the KMT2A transcriptional complex in acute lymphoblastic leukemia (2023) (0)
- Development and validation of a sensitive UPLC-MS/MS assay for the quantitation of corticosterone in rat plasma (2014) (0)
- A high-throughput screen indicates gemcitabine and JAK inhibitors may be useful for treating pediatric AML (2019) (0)
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