R. Heiner Schirmer

R. Heiner Schirmer's AcademicInfluence.com Rankings

R. Heiner Schirmer

Biology

#8192

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#11230

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Biochemistry

#1449

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#1574

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R. Heiner Schirmer

Philosophy

#8709

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#12140

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Logic

#6773

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#8321

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Biology
Philosophy

Why Is R. Heiner Schirmer Influential?

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According to Wikipedia, Rolf Heiner Schirmer was a German physician and biochemist. From 1980 to 2007 he was a professor of biochemistry in the medical faculty of Ruprecht-Karls University in Heidelberg, Germany, and became a professor emeritus.

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R. Heiner Schirmer's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Principles of Protein Structure (1979) (1260)
Substitution of the thioredoxin system for glutathione reductase in Drosophila melanogaster. (2001) (399)
Human Placenta Thioredoxin Reductase (1998) (375)
Thioredoxin reductase as a pathophysiological factor and drug target. (2000) (353)
“Lest we forget you — methylene blue …” (2011) (324)
Thioredoxin reductase two modes of catalysis have evolved. (2000) (311)
Dithiol proteins as guardians of the intracellular redox milieu in parasites: old and new drug targets in trypanosomes and malaria-causing plasmodia. (2005) (252)
Substrate positions and induced-fit in crystalline adenylate kinase. (1977) (241)
The Thioredoxin System of the Malaria Parasite Plasmodium falciparum (2000) (241)
The structure of the flavoenzyme glutathione reductase (1978) (236)
Three-dimensional structure of glutathione reductase at 2 A resolution. (1981) (219)
Three-dimensional structure of adenyl kinase (1974) (209)
Methylene blue as an antimalarial agent (2003) (204)
The mechanism of thioredoxin reductase from human placenta is similar to the mechanisms of lipoamide dehydrogenase and glutathione reductase and is distinct from the mechanism of thioredoxin reductase from Escherichia coli. (1997) (203)
Glutathione reductase from human erythrocytes. The sequences of the NADPH domain and of the interface domain. (1982) (188)
Disulfide‐Reductase Inhibitors as Chemotherapeutic Agents: The Design of Drugs for Trypanosomiasis and Malaria (1995) (188)
Active sites of thioredoxin reductases: Why selenoproteins? (2003) (185)
Trypanothione reductase from Trypanosoma cruzi (1987) (171)
Glutathione reductase from human erythrocytes. Isolation of the enzyme and sequence analysis of the redox-active peptide. (1977) (170)
Enzyme inactivation through sulfhydryl oxidation by physiologic NO-carriers (1998) (158)
5-substituted tetrazoles as bioisosteres of carboxylic acids. Bioisosterism and mechanistic studies on glutathione reductase inhibitors as antimalarials. (2004) (156)
Synthetic inhibitors of adenylate kinases in the assays for ATPases and phosphokinases. (1975) (155)
Interactions of Methylene Blue with Human Disulfide Reductases and Their Orthologues from Plasmodium falciparum (2007) (154)
Human thioredoxin reductase is efficiently inhibited by (2,2':6',2' '-terpyridine)platinum(II) complexes. Possible implications for a novel antitumor strategy. (2001) (131)
Glutathione – Functions and Metabolism in the Malarial Parasite Plasmodium falciparum (2003) (126)
FAD-binding site of glutathione reductase. (1982) (124)
Crystal Structure of the Antioxidant Enzyme Glutathione Reductase Inactivated by Peroxynitrite* (2002) (122)
Recombinant Plasmodium falciparum glutathione reductase is inhibited by the antimalarial dye methylene blue (1998) (122)
Glutathione reductase of the malarial parasite Plasmodium falciparum: crystal structure and inhibitor development. (2003) (121)
Topological comparison of adenyl kinase with other proteins (1974) (120)
Strong Gametocytocidal Effect of Methylene Blue-Based Combination Therapy against Falciparum Malaria: A Randomised Controlled Trial (2009) (120)
A prodrug form of a Plasmodium falciparum glutathione reductase inhibitor conjugated with a 4-anilinoquinoline. (2001) (117)
Methylene blue for malaria in Africa: results from a dose-finding study in combination with chloroquine (2006) (110)
In Vitro Assessment of Methylene Blue on Chloroquine-Sensitive and -Resistant Plasmodium falciparum Strains Reveals Synergistic Action with Artemisinins (2005) (104)
Structural relationships in the adenylate kinase family. (1986) (103)
Folding of the four domains and dimerization are impaired by the Gly446-->Glu exchange in human glutathione reductase. Implications for the design of antiparasitic drugs. (1993) (101)
A hypothesis on the catalytic mechanism of the selenoenzyme thioredoxin reductase. (1998) (101)
Superoxide release by zymosan-stimulated rat Kupffer cells in vitro. (1981) (100)
Safety and Efficacy of Methylene Blue Combined with Artesunate or Amodiaquine for Uncomplicated Falciparum Malaria: A Randomized Controlled Trial from Burkina Faso (2008) (94)
Glutathione reductase-catalyzed cascade of redox reactions to bioactivate potent antimalarial 1,4-naphthoquinones--a new strategy to combat malarial parasites. (2011) (94)
YANA – a software tool for analyzing flux modes, gene-expression and enzyme activities (2005) (90)
Oxidative stress as a defense mechanism against parasitic infections. (1987) (87)
Antioxidant Status and Nitric Oxide in the Malnutrition Syndrome Kwashiorkor (2001) (86)
X-ray structure of glutathione S-transferase from the malarial parasite Plasmodium falciparum (2003) (84)
Inhibition of human glutathione reductase by S-nitrosoglutathione. (1995) (83)
Interaction of a glutathione S-conjugate with glutathione reductase. Kinetic and X-ray crystallographic studies. (1984) (80)
Glutathione reductase from human erythrocytes: amino-acid sequence of the structurally known FAD-binding domain. (1981) (76)
The enzymatic synthesis of thiophosphate analogs of nucleotides. (1972) (75)
A fluoro analogue of the menadione derivative 6-[2'-(3'-methyl)-1',4'-naphthoquinolyl]hexanoic acid is a suicide substrate of glutathione reductase. Crystal structure of the alkylated human enzyme. (2006) (74)
Thioredoxin-2 but Not Thioredoxin-1 Is a Substrate of Thioredoxin Peroxidase-1 from Drosophila melanogaster (2002) (74)
The thioredoxin system of Plasmodium falciparum and other parasites (2002) (72)
Dinitrosyl-dithiol-iron complexes, nitric oxide (NO) carriers in vivo, as potent inhibitors of human glutathione reductase and glutathione-S-transferase. (1997) (66)
Inhibition of human glutathione reductase by the nitrosourea drugs 1,3-bis(2-chloroethyl)-1-nitrosourea and 1-(2-chloroethyl)-3-(2-hydroxyethyl)-1-nitrosourea. A crystallographic analysis. (1988) (66)
Human placenta thioredoxin reductase: preparation and inhibitor studies. (2002) (64)
Cloning and sequencing of mammalian glutathione reductase cDNA. (1990) (63)
Glutathione reductase and glutamate dehydrogenase of Plasmodium falciparum, the causative agent of tropical malaria. (1996) (62)
The 58 kDa mouse selenoprotein is a BCNU‐sensitive thioredoxin reductase (1997) (61)
Glutathione reductase inhibitors as potential antimalarial drugs. Effects of nitrosoureas on Plasmodium falciparum in vitro. (1988) (60)
The Mechanism of High Mr Thioredoxin Reductase from Drosophila melanogaster* (2003) (58)
Mechanism-based inactivation of thioredoxin reductase from Plasmodium falciparum by Mannich bases. Implication for cytotoxicity. (2003) (58)
Role of active site tyrosine residues in catalysis by human glutathione reductase. (1998) (58)
Glutathione and association antioxidant systems in protein energy malnutrition: results of a study in Nigeria. (1995) (58)
Kinetic Characterization of Glutathione Reductase from the Malarial Parasite Plasmodium falciparum (2000) (57)
Halothane binds in the adenine‐specific niche of crystalline adenylate kinase (1977) (56)
Molecular cloning and characterization of a putative glutathione reductase gene, the PfGR2 gene, from Plasmodium falciparum. (1996) (54)
Recombinant putative glutathione reductase of Plasmodium falciparum exhibits thioredoxin reductase activity. (1996) (54)
Deletion of the parasite-specific insertions and mutation of the catalytic triad in glutathione reductase from chloroquine-sensitive Plasmodium falciparum 3D7. (2000) (53)
Comparative structural analysis of oxidized and reduced thioredoxin from Drosophila melanogaster. (2005) (52)
Thioredoxin reductase from the malaria mosquito Anopheles gambiae. (2003) (52)
1,3-Bis(2-chloroethyl)-1-nitrosourea as thiol-carbamoylating agent in biological systems. (1995) (51)
Efficacy and safety of triple combination therapy with artesunate-amodiaquine-methylene blue for falciparum malaria in children: a randomized controlled trial in Burkina Faso. (2015) (50)
Trypanothione reductase from Trypanosoma cruzi. Purification and characterization of the crystalline enzyme. (1987) (50)
Mitochondrial GTP-AMP phosphotransferase. 1. Purification and properties. (1979) (49)
Plasmoredoxin, a novel redox-active protein unique for malarial parasites. (2003) (49)
Glutathione reductase-deficient erythrocytes as host cells of malarial parasites. (1988) (47)
Molecular basis of glutathione reductase deficiency in human blood cells. (2007) (47)
Primary and tertiary structure of the principal human adenylate kinase. (1976) (45)
Artemisinin resistance on the Thai–Cambodian border (2009) (43)
Inhibition of human glutathione reductase by 10-arylisoalloxazines: crystalline, kinetic, and electrochemical studies. (1996) (41)
Molecular Genetics Evidence for the in Vivo Roles of the Two Major NADPH-dependent Disulfide Reductases in the Malaria Parasite* (2010) (41)
Fluorescent and spin label probes of the environments of the sulfhydryl groups of porcine muscle adenylate kinase. (1975) (40)
Thioredoxin, thioredoxin reductase, and thioredoxin peroxidase of malaria parasite Plasmodium falciparum. (2002) (39)
The bacterial redox signaller pyocyanin as an antiplasmodial agent: comparisons with its thioanalog methylene blue (2011) (37)
Preparation and characterization of a crystalline human ATP:AMP phosphotransferase. (1972) (37)
Redox processes in malaria and other parasitic diseases (1994) (37)
Low resolution structure of adenylate kinase. (1973) (37)
Denaturation and reactivation of dimeric human glutathione reductase--an assay for folding inhibitors. (1997) (36)
Inherited Glutathione Reductase Deficiency and Plasmodium falciparum Malaria—A Case Study (2009) (35)
Haemolysis risk in methylene blue treatment of G6PD‐sufficient and G6PD‐deficient West‐African children with uncomplicated falciparum malaria: a synopsis of four RCTs (2013) (34)
Mitochondrial adenylate kinase (AK2) from bovine heart. Homology with the cytosolic isoenzyme in the catalytic region. (1984) (34)
Flavin analogs with antimalarial activity as glutathione reductase inhibitors. (1990) (34)
Plasmodium falciparum thioredoxins and glutaredoxins as central players in redox metabolism (2003) (33)
Eosin B as a Novel Antimalarial Agent for Drug-Resistant Plasmodium falciparum (2006) (32)
Dithiol Proteins as Guardians of the Intracellular Redox Milieu in Parasites: Old and New Drug Targets in Trypanosomes and Malaria-Causing Plasmodia (2005) (31)
Purification, characterization and crystallization of pork myokinase (1970) (30)
Studies on glutathione reductase and methemoglobin from human erythrocytes parasitized with Plasmodium falciparum. (1987) (29)
Trypanothione reductase from Trypanosoma cruzi. Catalytic properties of the enzyme and inhibition studies with trypanocidal compounds. (1989) (28)
Random silent mutagenesis in the initial triplets of the coding region: a technique for adapting human glutathione reductase-encoding cDNA to expression in Escherichia coli. (1990) (28)
Effects of antioxidants on glutathione levels and clinical recovery from the malnutrition syndrome kwashiorkor – a pilot study (2005) (27)
Plasmodium falciparum glutathione reductase exhibits sequence similarities with the human host enzyme in the core structure but differs at the ligand-binding sites. (1995) (27)
News and views on thioredoxin reductases. (1999) (25)
Mitochondrial adenylate kinase (AK2) from bovine heart. The complete primary structure. (1986) (25)
Cytotoxic interactions of methylene blue with trypanosomatid-specific disulfide reductases and their dithiol products. (2008) (24)
Myristoylated adenylate kinase-2 of Plasmodium falciparum forms a heterodimer with myristoyltransferase. (2009) (22)
Patterns of Folding and Association of Polypeptide Chains (1979) (21)
Microinjected glutathione reductase crystals as indicators of the redox status in living cells (1999) (21)
Glutathione reductase in human and murine lung tumors: high levels of mRNA and enzymatic activity. (1993) (20)
Sensitivity of adenylate kinase isozymes from normal and dystrophic human muscle to sulfhydryl reagents. (1972) (20)
FAD analogues as prosthetic groups of human glutathione reductase. Properties of the modified enzyme species and comparisons with the active site structure. (1985) (20)
The structural isomerisation of human-muscle adenylate kinase as studied by 1H-nuclear magnetic resonance. (1982) (19)
Adenylate kinase and GTP:AMP phosphotransferase of the malarial parasite Plasmodium falciparum. Central players in cellular energy metabolism. (2004) (19)
Protein-chemical standardization of the erythrocyte glutathione reductase activation test (EGRAC test). Application to hypothyroidism. (1991) (19)
Depletion of Plasmodium berghei Plasmoredoxin Reveals a Non-Essential Role for Life Cycle Progression of the Malaria Parasite (2008) (19)
Generating compatible translation initiation regions for heterologous gene expression in Escherichia coli by exhaustive periShine-Dalgarno mutagenesis. Human glutathione reductase cDNA as a model. (1992) (18)
Studies on the histidine residues of rabbit muscle myokinase. (1970) (18)
Noncovalent Forces Determining Protein Structure (1979) (17)
Properties of adenylate kinase after modification of Arg-97 by phenylglyoxal. (1978) (17)
A glutathione reductase-like flavoenzyme of the malaria parasite Plasmodium falciparum: structural considerations based on the DNA sequence. (1996) (16)
Prediction of Secondary Structure from the Amino Acid Sequence (1979) (16)
[26] Trypanothione and N1-glutathionylspermidine:Isolation and determination (1995) (15)
Insight into the selenoproteome of the malaria parasite Plasmodium falciparum. (2012) (15)
Synthesis and characterization of water‐soluble and photolabile 10‐arylisoalloxazines: Tools for studying the mechanism of action of flavin‐type antimalarials (1995) (13)
On the geometry of leukocyte NADPH‐oxidase, a membrane flavoenzyme (1983) (13)
NADPH-dependent disulphide reductases. (1989) (12)
A method to determine the carbamoylating potential of 1-(2-chloroethyl)-1-nitrosoureas. (1987) (11)
Protein-Ligand Interactions (1979) (11)
Flavins and flavoenzymes in diagnosis and therapy. (1999) (10)
Medical Target Prediction From Genome Sequence: Combining Different Sequence Analysis Algorithms with Expert Knowledge and Input From Artificial Intelligence Approaches (2001) (10)
A biochemical and electron microscope study of the contractile proteins in vettebrate smooth muscle (1966) (10)
Assembly and functional expression of murine glutathione reductase cDNA: a sequence missing in expressed sequence tag libraries. (2000) (10)
Human cytosolic adenylate kinase allelozymes; purification and characterization. (1990) (9)
Structural Implications of the Peptide Bond (1979) (8)
The Covalent Structure of Proteins (1979) (8)
Muscle adenylate kinase in Duchenne muscular dystrophy. (1986) (7)
The conserved histidine 106 of large thioredoxin reductases is likely to have a structural role but not a base catalyst function (2005) (6)
Trypanothione and N1-glutathionylspermidine: isolation and determination. (1995) (6)
Two modes of catalysis have evolved (2000) (5)
Flavoenzymes as drug targets (1984) (5)
Antimalarial activity of the ethanol/alcohol oxidase system in vitro. (1990) (4)
Safety and efficacy of methylene blue combined with artesunate or amodiaquine for uncomplicated falciparum malaria (2008) (4)
Flavoproteins of Known Three-Dimensional Structure (1983) (4)
Models, Display, and Documentation of Protein Structures (1979) (4)
[Elimination and excretion of adenylate kinases following cell damage]. (1975) (4)
NMR assignments of oxidised thioredoxin from Plasmodium falciparum (2009) (3)
1H, 13C, and 15N Sequence-specific Resonance Assignment and Secondary Structure of Plasmodium falciparum Thioredoxin (2005) (3)
CA/C1 peptidases of the malaria parasites Plasmodium falciparum and P. berghei and their mammalian hosts – a bioinformatical analysis (2009) (3)
Structure-Based Drug Development Against Malaria (2007) (3)
Superotemporal coloboma of the iris, ciliary body, and choroid. (1988) (3)
Thermodynamics and Kinetics of Polypeptide Chain Folding (1979) (2)
Strong gametocytocidal effect of methylene blue-based combination therapy against falciparum malaria (2009) (2)
No evidence for inhibition of human glutathione reductase by valproic acid. (1994) (2)
SOLUTION STRUCTURE OF AN HGR INHIBITOR, NMR, 10 STRUCTURES (1997) (1)
Kleines Lehrbuch von Format: Grundzüge der physiologischen Chemie. Von G. Löffler. Springer‐Verlag, Berlin – Heidelberg – New York – Tokyo 1983. XV, 359 S., 180 Abb., 52 Tab., geheftet DM 24,– (1984) (1)
1795-1995: Milestones in ROS research. (1995) (1)
The Structural Basis of Protein Mechanism, Action, and Function (1979) (1)
Hemoglobin: Structure, Function, Evolution, and Pathology. Von R. E. Dickerson und I. Geis. Benjamin/Cummings Publishing Co., Menlo Park, CA 1983. 176 S., geb. $ 40.50 ‐ ISBN 0‐8053‐2411‐9 (1984) (1)
Adenylate Kinase Isoenzymes in Intracranial Tumors (1985) (1)
Structure of the complex of the flavoenzyme glutathione reductase with NADPH (1982) (1)
Crystal structure of Plasmodium falciparum Glutathione reductase (2003) (1)
[Chronic lichenoid dermatitis in sensitization to alpha-amylase in a baker]. (1987) (1)
The reducing milieu of parasitized cells as a target of antimalarial agents: Methylene blue as an ethical drug (2011) (1)
[Extraction and purification of arterial actomycosin, actin and extra globulin]. (1965) (0)
Excited electronic states of flavin-containing coenzyme models (1988) (0)
Inorganic Tripolphosphate (PPP1) as Substrate for CrystallineAdenylate Kinases (1972) (0)
Structural studies on crystalline glutathione reductase from human erythrocytes (1978) (0)
THE EGRAC AS A MEASURE OF THE RIBOFLAVIN STATUS IN MAN. TITRATION OF HEMOLYS ATE FAD WITH APOGLUTATHIONE REDUCTASE (1991) (0)
The use of high performance liquid chromotography in the study of enzyme mechanism and evolution: active site labelling of D-amino acid oxidase; homology between lipoamide dehydrogenase and glutathione reductase (1981) (0)
HUMAN GLUTATHIONE REDUCTASE MODIFIED BY DINITROSOGLUTATHIONE (1998) (0)
Inogranic tripolyphosphate (PPPi) as substrate for crystalline adenylate kinases. (1972) (0)
The tertiary structure of myokinase (1972) (0)
Photoinactivation of glutathione reductase by hematoporphyrin and Al-phthalocyanine tetrasulfonate. (1996) (0)
Zweierlei Actomyosin in Rinder-Carotiden? (1964) (0)
[The particularities of contractile proteins of the arteries]. (1965) (0)
Drosophila thioredoxin, oxidized, P21 (2004) (0)
Structure of human glutathione reductase complexed with pyocyanin, an agent with antimalarial activity (2011) (0)
The Structure of Porcine Muscle Adenylate Kinase (1974) (0)
An Approach to the Taxonomy of Malaria Parasites on the Basis of Protein Structures: Adenylate Kinase and Glutathione Reductase as Examples (1983) (0)
BINDING OF FAD TO BCNU-TREATED APOGLUTATHIONE REDUCTASE (1991) (0)
Aktivität von Proteinen: Molecular Interactions and Activity in Proteins. Ciba Foundation Symposium 60. Excerpta Medica, Amsterdam, Oxford, New York 1978. VII, 279 S., 99 Abb. 23 Tab., geb. Dfl. 64,– (1979) (0)
HUMAN GLUTATHIONE REDUCTASE MODIFIED BY DIGLUTATHIONE-DINITROSO-IRON (1998) (0)
Flavoproteins in Medicine (2018) (0)
Glutathione Reductase Species Containing FAD Analogues (1984) (0)
Drospohila thioredoxin, oxidized, P42212 (2004) (0)
Identification of peptides in electron density maps of proteins: Sequencing strategies for proteins (1980) (0)
Book Review: Hemoglobin: Structure, Function, Evolution and Pathology. By R. E. Dickerson and I. Geis (1985) (0)
The mode of binding of nucleotides to glutathione reductase (1981) (0)
The three-dimensional structure of glutathione reductase and its substrate complexes at 0.3 nm resolution (1980) (0)
Essentielle Argininreste in Adenylat-Kinase und Pyruvat-Kinase aus Schweineherz (1976) (0)
Drosophila thioredoxin, reduced, P6522 (2004) (0)
We declare that we have no confl icts of interest. (2009) (0)
Drospohila thioredoxin, oxidized, P41212 (2004) (0)
Structural studies on crystalline adenylate kinase (1975) (0)
Synthesis and Characterization of Water‐Soluble and Photolabile 10‐ Arylisoalloxazines: Tools for Studying the Mechanism of Action of Flavin‐Type Antimalarials. (2010) (0)
STRUCTURAL COMPARISON OF THE FLAVOENZYME GLUTATHIONE REDUCTASE WITH OTHER PROTEINS (1981) (0)
In vitro synthesis of adenylate kinase directed by mRNA from human muscle (1979) (0)
Human Glutathione Reductase Inactivated by Peroxynitrite (2002) (0)
THREE-DIMENSIONAL STRUCTURE OF GLUTATHIONE REDUCTASE AT 2 ANGSTROMS RESOLUTION (1982) (0)
The interface between sequence analysis and X-ray diffraction analysis of protein (1977) (0)
Nutritional antioxidants: modulation in malnutrition and requirements. (2001) (0)

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