Ryszard Jerzy Gryglewski
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Ryszard Jerzy Gryglewskimedical Degrees
Medical
#2690
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#3121
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Pharmacology
#293
World Rank
#342
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Medical
Ryszard Jerzy Gryglewski's Degrees
- PhD Pharmacology Medical University of Gdańsk
Why Is Ryszard Jerzy Gryglewski Influential?
(Suggest an Edit or Addition)Ryszard Jerzy Gryglewski's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Flavonoids are scavengers of superoxide anions. (1988) (1359)
- Effects of anti-inflammatory drugs on prostaglandin biosynthesis. (1972) (459)
- Optical Projection Tomography as a Tool for 3D Microscopy and Gene Expression Studies (2002) (398)
- Generation of prostacyclin by lungs in vivo and its release into the arterial circulation (1978) (377)
- Clinical patterns of hypersensitivity to nonsteroidal anti-inflammatory drugs and their pathogenesis. (1977) (340)
- Mediators Produced by the Endothelial Cell (1988) (330)
- Human neutrophils and mononuclear cells inhibit platelet aggregation by releasing a nitric oxide-like factor. (1989) (305)
- Flavonoids are scavengers of superoxide anions (1988) (303)
- The generation of prostacyclin by arteries and by the coronary vascular bed is reduced in experimental atherosclerosis in rabbits. (1977) (282)
- Prostacyclin and thromboxane A2 biosynthesis capacities of heart, arteries and platelets at various stages of experimental atherosclerosis in rabbits. (1978) (255)
- Receptor-mediated release of endothelium-derived relaxing factor and prostacyclin from bovine aortic endothelial cells is coupled. (1988) (250)
- Bioactivity of flavonoids. (1996) (212)
- Gastric cytoprotection by epidermal growth factor: Role of endogenous prostaglandins and DNA synthesis (1981) (171)
- Prostacyclin among prostanoids. (2008) (153)
- Role of prostaglandins in the formation of aspirin-induced gastric ulcers (1981) (142)
- The effect of six prostaglandins, prostacyclin and iloprost on generation of superoxide anions by human polymorphonuclear leukocytes stimulated by zymosan or formyl-methionyl-leucyl-phenylalanine. (1987) (106)
- The release of prostaglandins and rabbit aorta contracting substance (RCS) from rabbit spleen and its antagonism by anti‐inflammatory drugs (1972) (104)
- Prostaglandins, platelets, and atherosclerosis. (1980) (98)
- Experimental atherosclerosis in rabbits: platelet aggregation, thromboxane A2 generation and anti-aggregatory potency of prostacyclin. (1977) (97)
- Gastric cytoprotection by epidermal growth factor. Role of endogenous prostaglandins and DNA synthesis. (1981) (94)
- Low density lipoproteins (LDL) are carriers for lipid peroxides and inhibit prostacyclin (PGI2) biosynthesis in arteries. (1980) (91)
- Anti-platelet action of intravenous infusion of prostacyclin in man. (1978) (83)
- Role of prostaglandins in the formation of aspirin-induced gastric ulcers. (1981) (80)
- Prostacyclin and Its Stable Analogue Iloprost (1987) (79)
- The endothelial cell as a metabolic and endocrine organ (1987) (73)
- De-aggregatory action of prostacyclin in vivo and its enhancement by theophylline. (1978) (68)
- Prostacyclin formation by myometrial & decidual fractions of the pregnant rat uterus. (1978) (65)
- Effects of nitric oxide and prostacyclin on deformability and aggregability of red blood cells of rats ex vivo and in vitro. (1999) (65)
- The generation from arachidonic acid of rabbit aorta contracting substance (RCS) by a microsomal enzyme preparation which also generates prostaglandins (1972) (63)
- Significance of endothelial prostacyclin and nitric oxide in peripheral and pulmonary circulation. (2001) (62)
- The effect of 4-acetamidophenol on prostaglandin synthetase activity in bovine and ram seminal vesicle microsomes. (1978) (61)
- Angiotensin converting enzyme (ACE) and HydroxyMethylGlutaryl-CoA (HMG-CoA) reductase inhibitors in the forefront of pharmacology of endothelium. (2005) (59)
- Effect of Prostacyclin on Fibrinolytic Activity in Patients with Arteriosclerosis Obliterans (1982) (56)
- Nitric oxide from polymorphonuclear leukocytes modulates red blood cell deformability in vitro. (1993) (55)
- The inactivation of noradrenaline and isoprenaline in dogs (1970) (49)
- The role of nitric oxide in regulation of deformability of red blood cells in acute phase of endotoxaemia in rats. (1997) (47)
- Prostacyclin, Nitric Oxide, and Atherosclerosis a (1994) (44)
- Antioxidant properties of some chemicals vs their influence on cyclooxygenase and lipoxidase activities. (1983) (42)
- Synthesis and Properties of 2-Carboxyalkyl-1,2-benzisoselenazol-3(2H)-ones and Related Organoselenium Compounds as Nitric Oxide Synthase Inhibitors and Cytokine Inducers (1996) (42)
- Reversal of platelet aggregation by prostacyclin. (1978) (41)
- Comparison of Endothelial Pleiotropic Actions of Angiotensin Converting Enzyme Inhibitors and Statins (2001) (41)
- Prostacyclin and atherosclerosis (1979) (39)
- Protective role of pulmonary nitric oxide in the acute phase of endotoxemia in rats. (1998) (39)
- Interactions between nitric oxide and prostacyclin. (1993) (38)
- A possible role of thromboxane A2 (TXA2) and prostacyclin (PGI2) in circulation. (1978) (38)
- The effect of prostacyclin and nitric oxide on deformability of red blood cells in septic shock in rats. (1996) (37)
- Morphine antagonises prostaglandin E1- mediated inhibition of human platelet aggregation (1975) (37)
- Interactions between endothelial mediators. (1995) (37)
- Modulation of the pharmacological actions of nitrovasodilators by methylene blue and pyocyanin (1992) (35)
- Acetate metabolism in brain mechanisms of adaptation to ethanol. (2003) (32)
- Umbilical arteries of babies born to cigarette smokers generate less prostacyclin and contain less arginine and citrulline compared with those of babies born to control subjects. (1995) (30)
- Prostacyclin and thromboxane generating systems in rabbits pretreated with aspirin. (1978) (30)
- Antiaggregatory effects of flavonoids in vivo and their influence on lipoxygenase and cyclooxygenase in vitro. (1984) (29)
- Mesoionic oxatriazole derivatives--a new group of NO-donors. (1994) (28)
- In vivo method for quantitation of anti-platelet potency of drugs (1978) (28)
- Eicosanoids, Aspirin, and Asthma (1998) (27)
- Rabbit-aorta contracting substance (RCS) may be a prostaglandin precursor. (1971) (27)
- Bradykinin as a major endogenous regulator of endothelial function. (2002) (26)
- Cyanonitrosylmetallates as potential NO-donors. (1998) (24)
- Fibrinolytic Activity of 6-Keto-Prostaglandin E1 (1983) (23)
- Treatment with L-arginine is likely to stimulate generation of nitric oxide in patients with peripheral arterial obstructive disease. (1996) (22)
- Molecular mechanisms of inflammation. (1981) (22)
- A potent inhibitor of thromboxane A2 biosynthesis in aggregating human blood platelets. (1977) (22)
- The fibrinolytic activity of N-arylanthranilates. (1966) (21)
- Pharmacology of vascular endothelium (2005) (21)
- Nitric oxide : basic research and clinical applications (2001) (21)
- The lung as a generator of prostacyclin. (1980) (21)
- The influence of saturated fatty acids on prostaglandin synthetase activity. (1975) (21)
- Interaction Between NO Donors and Iloprost in Human Vascular Smooth Muscle, Platelets, and Leukocytes (1989) (20)
- A release of prostaglandins may be responsible for acute tolerance to norepinephrine infusions. (1974) (19)
- Interactions between human platelets and eosinophils are mediated by selectin-P. (2002) (19)
- Selectin-P-mediated adherence of platelets to neutrophils is regulated by prostanoids and nitric oxide. (1993) (19)
- Asthma and anti-inflammatory drugs. Mechanisms and clinical patterns. (1983) (18)
- Angiotensin-induced release of prostacyclin (PGI2) into circulation of anaesthetized cats. (1979) (18)
- Prostaglandin E2 in gastric mucosa and its role in the prevention of ulcers induced by acetyl salicylic acid in cats. (1981) (17)
- Aspirin Sensitivity: Other Drugs (1975) (16)
- Interactions between endothelial secretogogues. (1995) (16)
- The effect of nitric oxide donors on the release of plasminogen activator inhibitor (PAI) from rabbit platelets in vitro. (1995) (16)
- In vivo endothelial interaction between ACE and COX inhibitors. (2005) (15)
- Statins rise cytoplasmic calcium level [Ca2+]i in cultured endothelial cells. (2004) (14)
- Interaction between stimulators of adenylate and guanylate cyclases in human leukocytes, platelets and arteries. (1989) (14)
- NG-hydroxy-L-arginine and hydroxyguanidine potentiate the biological activity of endothelium-derived relaxing factor released from the rabbit aorta. (1992) (14)
- Prostaglandins and aspirin-sensitive asthma. (2015) (13)
- Cytoprotection of human polymorphonuclear leukocytes by stimulators of adenylate and guanylate cyclases. (1989) (13)
- Inhibition of prostacyclin formation by lipid peroxides in the arterial wall: hypothetical step in development of atherosclerosis. (1978) (13)
- The Impact of Prostacyclin Studies on the Development of Its Stable Analogues (1987) (12)
- Screening for inhibitors of prostaglandin and thromboxane biosynthesis. (1978) (12)
- Nitric oxide donors as generators and scavengers of superoxide anions. (1993) (12)
- Hypoxic pulmonary vasoconstriction in isolated blood-perfused rat lung; modulation by thromboxane A2, platelet-activating factor, cysteinyl leukotrienes and endothelin-1. (2002) (11)
- Effect of L-arginine on plasminogen-activator inhibitor in hypertensive patients with hypercholesterolemia. (1993) (11)
- Unusual effects of aspirin on ticlopidine induced thrombolysis (2000) (11)
- Prostaglandins in therapy of cardiovascular disease. (1985) (10)
- Fibrinolytic Activity of some Biarylcarboxylic Acids (1967) (10)
- Conversion of exogenous arachidonic acid to prostaglandins in the pulmonary circulation in vivo. A human and animal study. (1981) (9)
- Endothelial nitric oxide, prostacyclin (PGI2) and tissue plasminogen activator (t-PA): alliance or neutrality? (1995) (9)
- Endothelial control of coronary flow in perfused guinea pig heart (1995) (9)
- BRADYKININ AS A MAJOR ENDOGENOUS REGULATOR OF ENDOTHELIAL FUNCTION (2002) (9)
- Mesoionic oxatriazoles (MOTA): NO-donating characteristics and pharmacology. (2002) (8)
- The influence of propranolol, INPEA, iproveratril and some 1-naphthylethylamine derivatives on the myocardial phosphorylase activity. (1970) (8)
- Ischaemic cardiac hyperaemia: role of nitric oxide and other mediators. (1996) (8)
- BIOASSAY OF HISTAMINE IN THE PRESENCE OF PROSTAGLANDINS (1976) (8)
- Prostacyclin and Atherosclerosis—A Hypothesis (1980) (8)
- Platelets in fibrinolytic system. (1995) (8)
- Disaggregatory action of phosphodiesterase inhibitors. (1981) (7)
- A biological method for studying the interaction between platelets and vascular endothelium. (1990) (7)
- Nitric oxide donation and nitrite assays in the presence of thiols and albumin as determined by Griess' and Werringloer's methods. (1997) (7)
- Pneumotoxicity of lipopolysaccharide in nitric oxide-deficient rats is limited by a thromboxane synthase inhibitor. (1997) (7)
- Release of a prostaglandin E-like substance into mixed venous blood during endotoxin hypotension in cats. (1975) (7)
- Pharmacology of vascular endothelium. Delivered on 27 June 2004 at the 29th FEBS Congress in Warsaw. (2005) (7)
- Prostacyclin and nitric oxide. (1994) (7)
- Prostaglandin and thromboxane biosynthesis inhibitors (2004) (6)
- Binding of the membrane active drugs to bovine serum albumin and human erythrocyte membranes. (1975) (6)
- Salicylates and 12-lipoxygenase activity in human washed platelets. (1986) (6)
- Aspirin-induced asthma and cyclooxygenases (1998) (6)
- Contribution of arachidonic acid metabolites to atherosclerosis. (1986) (6)
- In vitro generation and decomposition of S-nitrosothiols from direct and indirect nitric oxide donors. (1995) (6)
- Prostaglandin feedback mechanism limits vasoconstrictor action of norepinephrine in perfused rabbit ear (1975) (6)
- Scavenging of superoxide anions by nitric oxide donors (1992) (6)
- Prostacyclin--experimental and clinical approach. (1983) (6)
- Nitric oxide complements prostacyclin in the regulation of endothelial thromboresistance under flow conditions. (1993) (6)
- The influence of hydrocortisone and indomethacin on the release of prostaglandin-like substances during circulatory shock in cats, which was induced by an intravenous administration of rabbit blood. (1978) (6)
- Participation of prostaglandins in pathogenesis of aspirin-sensitive asthma (2004) (6)
- Release of prostacyclin from the human pulmonary vascular bed in response to cholinergic stimulation (2004) (5)
- Endogenous factors affecting arachidonic acid metabolism: I. Biosynthesis of prostacyclin and prostaglandins by carrageenin granulomas of rats (1978) (5)
- Prostacyclin and atherosclerosis--experimental and clinical approaches. (1988) (5)
- The Influence of Some 1-Substituted 6-Methoxy-1,2,3,4-tetrahydro-β-carbolines on the Metabolism and Activity of 5-Hydroxytryptamine (1966) (5)
- Mass-spectrometric evidence for spontaneous and angiotensin-induced generation of prostacyclin by perfused cat lungs. (1980) (5)
- Interactions between reactive oxygen species and sulfhydryl groups of cysteine, acetylcysteine and glutathione. (1995) (5)
- Design of a new prostaglandin synthetase inhibitors in a group of N-(2-carboxyphenyl)phenoxyacetamides and their antiinflammatory activity. (1976) (4)
- Vane's blood-bathed organ technique adapted to examine the endothelial effects of cardiovascular drugs in vivo. (2010) (4)
- Effects of prostanoids on generation of superoxide ions by human neutrophils. (1987) (4)
- Flavonoids — Lipoxygenases — Platelet Aggregation (1985) (4)
- Influence of SIN-1 and sodium nitroprusside (NANP) on ox-LDL metabolism in macrophages. (1994) (4)
- A neutrophil-derived NO-synthase (NOS) inhibitor. (1995) (4)
- Sir John Robert Vane (1927–2004) (2010) (3)
- A possible role of endothelial vasorelaxants in the pathogenesis of migraine (1990) (3)
- On the mechanism of angiotensin II induced release of prostacyclin. (1981) (3)
- Eicosanoid balance at early stages of experimental atherosclerosis. Its relationship with plasma fibrinolytic activity and platelet aggregation. (1986) (3)
- pH-dependent release of EDRF from rabbit aortic endothelium. (1990) (3)
- Transcellular biosynthesis of eicosanoids. (1999) (3)
- Prostaglandins and Vascular Wall (1977) (3)
- Organic anions which induce fibrinolysis in vitro. (1966) (3)
- Almitrine increases plasma fibrinolytic activity through the release of prostacyclin from lungs into circulation. (1982) (3)
- Permissive effect of molsidomine towards cardioprotective action of iloprost in myocardial ischemia in cats. (1993) (3)
- In vitro and in vivo models for evaluating drugs which influence arachidonic acid metabolism. (1979) (3)
- Influence of no-donor (SIN-1) on functions of inflammatory cells (2005) (3)
- John R. Vane (1927–2004) (2005) (2)
- A paradox of thrombogenesis by streptokinase and its prevention by iloprost and camonagrel. (1996) (2)
- Pharmacological Interference in Biotransformation of Arachidonic Acid (1979) (2)
- Myocardial reactive hyperaemia in perfused guinea pig heart. (1995) (2)
- Prostacyclin in the treatment of atherosclerosis obliterans and other vascular diseases. (1984) (2)
- Carrageenin hyperthermia in rats (1974) (2)
- Influence of INPEA, pindolol and propranolol on the chronotropic and metabolic responses to -adrenergic stimulation in intact rats. (1971) (2)
- PROSTACYCLIN AS AN ANTI-ATHEROSCLEROTIC HORMONE - A HYPOTHESIS (1981) (2)
- Pharmacological Interference in Arachidonic Acid Cascade (1981) (2)
- Cardioprotection by molsidomine and iloprost in myocardial ischemia in anaesthetized cats. (1992) (2)
- Streptokinase-prostacyclin--nitric oxide: in vivo interactions. (1995) (2)
- [Significance of arachidonic acid cascade in cardiology]. (1978) (1)
- Metabolites of arachidonic acid in the lung. (1987) (1)
- On the mechanism of thrombogenesis during pharmacological thrombolysis. (1996) (1)
- Bioassay of Prostacyclin and Thromboxane A2 (1981) (1)
- Eicosanoids in aspirin-induced asthma. (1989) (1)
- Effects of prostacyclin in atherosclerotic vascular disease. (1985) (1)
- Letter: Aspirin sensitivity: other drugs. (1975) (1)
- Crossroads of L-Arginine/Arachidonate Metabolism (1997) (1)
- The role of oxygen free radicals in the destruction of endothelium-derived relaxing factor (EDRF) (1987) (1)
- Cellular and Humoral Markers of Tissue Damage (1996) (1)
- The effect of insulin and tolbutamide on the reduced glutathione concentration in the blood of diabetic and non-diabetic persons. (1961) (1)
- Secretory function of vascular endothelium and its implication in the action of vasoactive drugs. (1990) (1)
- The evolution of ideas in prostaglandin research. (1980) (1)
- A triple test for screening biological activity of prostacyclin analogues (1978) (1)
- [Pharmacological research on the structure of adrenergic receptors in the heart]. (1972) (0)
- [Recent views on the metabolism of biogenic amines]. (1960) (0)
- Interaction between prostacyclin and nitric oxide TN white blood cells (1990) (0)
- [Mechanisms regulating the release of deaggregating prostanoids]. (1982) (0)
- [Effect of a series of indole derivatives on monoamine oxidase activity]. (1971) (0)
- PROSTACYCLIN - CLINICAL IMPLICATIONS OF BIOLOGICAL ACTIONS1 (1980) (0)
- 20-Methyl-prostacyclin analogs--a two stage screening procedure for biological properties. (1978) (0)
- The application of ultrasounds for detection of scavenging of superoxide anions by drugs. (1991) (0)
- Prostaglandins, platelets, lipids: New developments in atherosclerosis (1982) (0)
- The Endothelium: A New Secretory Organ Target or Promoter of Pathophysiological Derangements in ICU Patients (1996) (0)
- Review article The role of endothelium in pharmacotherapy of diabetic angiopathies (2007) (0)
- Central nervous action of alpha-aminobutyrylcholine. (1965) (0)
- Interaction between prostacyclin and molsidomine in blood cells and plasma. (1991) (0)
- Crossroads of medicine and chemistry in the 20th century (2007) (0)
- From Hippocrates to statistics. A historical perspective (2015) (0)
- On the mechanism of reactive hyperaemia in perfused guinea pig heart (1995) (0)
- 1139 – PROSTAGLANDINS AND PROSTAGIANDIN SYNTHESIS INHIBITORS IN ETIOLOGY AND TREATMENT OP INFLAMMATION (1977) (0)
- ENDOTOXIN-INDUCED ACUTE RESPIRATORY DISTRESS SYNDROME IN NITRIC OXIDE-DEFICIENT RATS (1998) (0)
- 2184 – THE GENERATION OF PROSTACYCLIN BY ARTERIES AND BY THE CORONARY VASCULAR BED DURING THE DEVELOPMENT OF EXPERIMANTAL ATHEROSCLEROSIS IN RABBITS (1978) (0)
- Anti-aggregatory prostanoids. Part II. (1985) (0)
- The effect of tolbutamide and insulin on the reduced glutathione content of the blood and liver of normal and alloxan-diabetic rats. (1961) (0)
- Synthesis and Properties of 2-Carboxyalkyl-1,2-benzisoselenazol-3(2H)- ones and Related Organoselenium Compounds as Nitric Oxide Synthase Inhibitors and Cytokine Inducers. (1997) (0)
- [ROMEK. In memory of professor Roman Rembies--on the 20th anniversary of his death]. (2005) (0)
- Selectin P (PADGEM GMP-140)—Mediated Adhesion of Human Platelets to Neutrophils in Vitro and the Immune Complex-induced Peritoneitis in Rats is Influenced by Interleukin-8 (1995) (0)
- [Endogenous substances with high biological activity--their pharmaco-therapeutic significance]. (1976) (0)
- Male portrait head (2009) (0)
- In Memoriam (2013) (0)
- Humoral Homeostasis — Role of Vascular Endothelium (1997) (0)
- Dietary PUFAs, lipid peroxides, atherosclerosis, aspirin. (1979) (0)
- Prostaglandins and the mechanism of drug action in circulatory system. (1976) (0)
- [Prostacyclins and arteriosclerosis]. (1979) (0)
- Changes in coronary endothelial function during progression of cardiac hypertrophy and failure in TGαq∗44 mice (2002) (0)
- 982 – NORA DRENALINE-INDUCED RELEASE OP PROSTAGLANDINS E FROM THE PERFUSED BLOOD VESSELS OF THE RABBIT. (1977) (0)
- [New arylsulfonylurea antidiabetics]. (1957) (0)
- Relations between endothelial secretogogues: Alliance or neutrality? (1995) (0)
- Modulation of LDL catabolism by sodium nitroprusside and PGE2 in human peripheral blood lymphocytes. (1994) (0)
- Anti-aggregatory prostanoids. Part I. (1985) (0)
- [Endogenous nitroglycerin]. (1990) (0)
- Prostacyclin in vascular pathology--therapeutic possibilities. (1984) (0)
- Regulatory role of oxygen and lipid free radicals in the secretory function of endothelium (1987) (0)
- [Medical pharmacogenetics. I. Methods applied in pharmacogenetic studies]. (1967) (0)
- Unknown faces of known drugs (2008) (0)
- Prostacyclin in Therapy of Vascular Disease (1985) (0)
- [Prostacyclin, EDRF and arteriosclerosis]. (1989) (0)
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