Richard J. Gryglewski
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Richard J. Gryglewskimedical Degrees
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#2792
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#3227
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Pharmacology
#311
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#361
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Richard J. Gryglewskiphilosophy Degrees
Philosophy
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#11270
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Ontology
#91
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#102
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#5008
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#6361
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Medical Philosophy
Richard J. Gryglewski's Degrees
- PhD Pharmacology University of California, San Francisco
- Doctorate Medicine University of California, San Francisco
Why Is Richard J. Gryglewski Influential?
(Suggest an Edit or Addition)Richard J. Gryglewski's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation (1976) (3173)
- Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor (1986) (2461)
- Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides. (1976) (997)
- Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac ateries and inhibits platelet aggregation. (1976) (949)
- A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation. (1976) (594)
- Relationship of inhibition of prostaglandin biosynthesis by analgesics to asthma attacks in aspirin-sensitive patients. (1975) (456)
- On the mechanism of antithrombotic action of flavonoids. (1987) (429)
- Corticosteroids inhibit prostaglandin release from perfused mesenteric blood vessels of rabbit and from perfused lungs of sensitized guinea pig. (1975) (341)
- SUCCESSFUL THERAPY OF ADVANCED ARTERIOSCLEROSIS OBLITERANS WITH PROSTACYCLIN (1979) (283)
- Bioassay of prostacyclin and endothelium‐derived relaxing factor (EDRF) from porcine aortic endothelial cells (1997) (243)
- Mechanism of action of some inhibitors of endothelium-derived relaxing factor. (1986) (212)
- Circulatory and anti-platelet effects of intravenous prostacyclin in healthy men. (1978) (186)
- Flavonoids and nitric oxide synthase. (2002) (160)
- Effects of all cis-5,8,11,14,17 eicosapentaenoic acid and PGH3 on platelet aggregation. (1979) (152)
- Thromboxane Generation and Platelet Aggregation in Survivals of Myocardial Infarction (1978) (130)
- Dietary Supplementation with Vitamin E in Hyperlipoproteinemias: Effects on Plasma Lipid Peroxides, Antioxidant Activity, Prostacyclin Generation and Platelet Aggregability (1985) (117)
- Regulation of cyclooxygenase by the heme-heme oxygenase system in microvessel endothelial cells. (2002) (109)
- Involvement of nitric oxide in the endothelium‐dependent relaxation induced by hydrogen peroxide in the rabbit aorta (1993) (95)
- Pulmonary and anti-platelet effects of intravenous and inhaled prostacyclin in man (1978) (90)
- Generation of prostaglandin E‐like material by the guinea‐pig trachea contracted by histamine (1975) (89)
- Treatment of ischaemic stroke with prostacyclin. (1983) (83)
- Inhibition of endothelial nitric oxide synthase by ebselen. Prevention by thiols suggests the inactivation by ebselen of a critical thiol essential for the catalytic activity of nitric oxide synthase. (1993) (76)
- Prostacyclin as a circulatory hormone. (1979) (73)
- Steroid hormones, anti-inflammatory steroids and prostaglandins. (1976) (71)
- Anti‐atherogenic effect of statins: role of nitric oxide, peroxynitrite and haem oxygenase‐1 (2009) (70)
- Serum lipoproteins, lipid peroxides and prostacyclin biosynthesis in patients with coronary heart disease. (1981) (66)
- Prostacyclin therapy in peripheral arterial disease. (1980) (60)
- Endothelial action of thienopyridines and thienopyrimidinones in the isolated guinea pig heart. (2005) (58)
- Selective inhibition of thromboxane A2 biosynthesis in blood platelets (1977) (57)
- Interleukin 1beta induces functional prostaglandin E synthase in cultured human umbilical vein endothelial cells. (2002) (47)
- Thrombolytic action of ticlopidine: possible mechanisms. (1996) (43)
- Preparation and biochemical properties of PGH3. (1979) (43)
- PROSTACYCLIN IN CENTRAL RETINAL VEIN OCCLUSION (1980) (41)
- Aspirin-sensitive asthma: the effect of aspirin on the release of prostaglandins from nasal polyps. (1977) (39)
- No-dependent vasodilation induced by nebivolol in coronary circulation is not mediated by beta-adrenoceptors or by 5 HT1A-receptors. (2002) (37)
- Platelet aggregability, thromboxane A2 and malonaldehyde formation following administration of aspirin to man. (1979) (34)
- Lack of beneficial effects of L-arginine infusion in primary pulmonary hypertension. (1994) (34)
- Asthma relieved by aspirin and by other cyclo-oxygenase inhibitors. (1978) (32)
- Double-blind controlled trial of the therapeutic effects of prostacyclin in patients with completed ischaemic stroke. (1985) (32)
- Thienopyridines: effects on cultured endothelial cells. (1999) (31)
- Antiplatelet action of losartan involves TXA2 receptor antagonism but not TXA2 synthase inhibition. (2000) (29)
- Aspirin-induced asthma. Hypersensitivity to fenoprofen and ibuprofen in relation to their inhibitory action on prostaglandin generation by different microsomal enzymic preparations. (1976) (29)
- Obligatory role of lipid mediators in platelet-neutrophil adhesion. (2003) (28)
- Asthmatic attacks induced in aspirin-sensitive patients by diclofenac and naproxen. (1977) (28)
- Screening and Assessment of the Potency of Anti-Inflammatory Drugs in vitro (1979) (28)
- Endogenous mechanisms that regulate prostacyclin release. (1980) (24)
- Mechanisms of angiotensin-converting enzyme inhibitor induced thrombolysis in Wistar rats. (2003) (23)
- Platelet aggregation and thromboxane A2 formation in cat platelet rich plasma. (1978) (23)
- Synthesis and thrombolytic activity of new thienopyrimidinone derivatives. (2002) (21)
- Angiotensin-induced release of prostacyclin from perfused organs. (1980) (21)
- Generation of Prostaglandin and Thromboxane-Like Substances by Large Airways and Lung Parenchyma (1977) (19)
- The effect of nitric oxide synthase inhibition on the plasma fibrinolytic system in septic shock in rats (1994) (19)
- Reversal of the postischaemic suppression of coronary function in perfused guinea pig heart by ischaemic preconditioning. (1999) (19)
- Clinical use of prostacyclin (PGI2) in ischaemic stroke. (1982) (19)
- Nitric oxide donors induce extrusion of cyclic GMP from isolated human blood platelets by a mechanism which may be modulated by prostaglandins. (1995) (18)
- Endogenous mechanisms which regulate prostacyclin release. (1979) (18)
- Thrombolysis by thienopyridines and their congeners. (2000) (17)
- Nitric oxide is a major mediator in reactive hyperaemia evoked by a brief coronary occlusion in the guinea pig heart. (1993) (17)
- Biphasic response to lipopolysaccharide from E. coli in the isolated ventilated blood-perfused rat lung. (1999) (17)
- Release of prostaglandin E‐like material from perfused mesenteric blood vessels of rabbits (1976) (17)
- The mechanism of anti-thrombotic, thrombolytic and fibrinolytic actions of camonagrel--a new thromboxane synthase inhibitor. (1995) (16)
- An abnormality of arachidonic acid metabolism is not a generalized phenomenon in patients with aspirin-induced asthma. (1988) (16)
- Effects of endothelin-1 and endothelin-3 on the release of prostanoids from isolated perfused rat kidney. (1991) (16)
- Polyunsaturated fatty acids and thrombosis (1979) (15)
- Aspirin-Sensitive Asthma: Its Relationship to Inhibition of Prostaglandin Biosynthesis (1977) (15)
- Lungs as a generator of prostacyclin — Hypothesis on physiological significance (1978) (13)
- Release of prostacyclin by the lung. (1981) (13)
- Prostacyclin and molsidomine synergise in their fibrinolytic and anti-platelet actions in patients with peripheral arterial disease. (1993) (12)
- L-arginine--substrate for no synthesis--its beneficial effects in therapy of patients with peripheral arterial disease: comparison with placebo-preliminary results. (1996) (12)
- Clonidine-induced coronary vasodilatation in isolated guinea pig heart is not mediated by endothelial alpha2 adrenoceptors. (2003) (12)
- Dihomo-γ-Linolenic Acid in Patients with Atherosclerosis: Effects on Platelet Aggregation, Plasma Lipids and Low-Density Lipoprotein-Induced Inhibition of Prostacyclin Generation-Reply (1984) (11)
- The endothelium-dependent and the endothelium-independent vasodilators in the isolated, perfused guinea pig heart. (1992) (11)
- Prostacyclin and the mechanism of action of defibrotide. (1989) (11)
- Carboxyebselen a potent and selective inhibitor of endothelial nitric oxide synthase. (1994) (11)
- beta-Pyridylcarbinol (Ronicol) releases a prostacyclin-like substance into arterial blood of patients with arteriosclerosis obliterans. (1983) (10)
- Arachidonic acid-induced platelet aggregation and thromboxane A2 generation in patients with coronary heart disease. (1978) (10)
- Mechanisms of the Endothelium‐Dependent Relaxation Induced by NG‐Hydroxy‐L‐Arginine (1992) (10)
- Paradoxical augmentation of bradykinin-induced vasodilatation by xanthine/xanthine oxidase-derived free radicals in isolated guinea pig heart. (2002) (10)
- L-N6-(1-iminoethyl)-lysine (L-NIL) but not S-methylisothiourea sulphate (SMT) displays selectivity towards NOS-2. (1999) (9)
- Endothelial Secretory Function and Atherothrombosis (2004) (8)
- Thrombolytic and antiplatelet action of xanthinol nicotinate (Sadamin): possible mechanisms. (1998) (7)
- On the Mechanism of Thrombolytic Action of Thromboxane Synthetase Inhibitors (1987) (7)
- Fibrinolytic Activity and the Effects of Beta-Pyridylcarbinol (Ronicol) in Patients with Arteriosclerosis Obliterans (1983) (7)
- Beneficial results of pentoxifylline ('Trental') therapy in arteriosclerosis obliterans: possible mechanism of action. (1985) (7)
- Effects of two beta3-agonists, CGP 12177A and BRL 37344, on coronary flow and contractility in isolated guinea pig heart. (2003) (7)
- Effect of ticlopidine on streptokinase-induced thrombolysis in rats. (1999) (7)
- Secretory function of vascular endothelium. (1987) (7)
- Eosinophil-epithelial cell interaction augments cysteinyl leukotrienes synthesis. (2002) (6)
- Action of beta-adrenolytics on the isolated guinea-pig atria. (1971) (6)
- The dual action of meclofenamate on the contractile response to PGF2 alpha in the guinea-pig trachea. (1975) (6)
- Plasma ANP and cyclic GMP after physical exercise in patients with mitral valve disease and in healthy subjects. (1993) (5)
- Myocardial necroses produced by intravenous infusion of isoprenaline into rats (1971) (5)
- Thrombolytic activity of beta-adrenolytic drug, sotalol. (1998) (5)
- Chapter 3 The prostacyclins (1983) (5)
- Some experimental models for the study of inflammation and anti-inflammatory drugs. (1977) (4)
- Aspirin, prostaglandins, and bronchial asthma. (1980) (4)
- [The effect of treatment with sulphur water from the spring in Wiesław in Busko-Solec on levels of lipids,the fibrinolytic system and thrombogenic platelet function in patients with arteriosclerosis]. (1997) (4)
- Prostaglandin synthetase activity in the renal medulla of normal and hypertensive rats. (1974) (4)
- INTERLEUKIN 1β INDUCES FUNCTIONAL PROSTAGLANDIN E SYNTHASE IN CULTURED HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS (2002) (4)
- Prostacyclin and vascular disease. (1981) (4)
- Effect of corticosteroids on the release of histamine and prostaglandins from fragments of mesentery of immunized guinea pigs. (1978) (4)
- Role of thromboxane A2 and platelet activating factor in early haemodynamic response to lipopolysaccharide in rats. (1999) (4)
- Increased pneumotoxicity of lipopolysaccharide from E.coli in nitric oxide deficient blood-perfused rat lungs. (1997) (4)
- Bioassay of prostacyclin and endothelium‐derived relaxing factor (EDRF) from porcine aortic endothelial cells (1986) (3)
- [Use of prostacyclin in patients with ischemic stroke. A double-blind method II]. (1988) (3)
- Vasorelaxant and platelet-suppressant potencies of four NO-donors. (1990) (3)
- Regulatory role of prostaglandins in the vascular system. (1975) (3)
- Endothelium-derived relaxing factor (EDRF) from cultured and fresh endothelial cells. (1988) (3)
- Aspirin sensitive asthma and arachidonic acid transformation. (1986) (3)
- Stimulatory cholinergic effect on the release of antiaggregatory activity into the circulation of cat and man and its modification by β‐adrenergic antagonists (1985) (2)
- Asthma and nonsteroidal anti-inflammatory drugs. (1979) (2)
- [Prostacyclin in treatment of peripheral vascular disease of lower extremities (author's transl)]. (1980) (2)
- Kinins and thrombolysis. (1993) (2)
- Prostaglandin-like substances inPropionibacterium acnes. V. Activity profiles using cascade superfusion bioassay and platelet aggregation (1981) (2)
- Haemodynamic and antihypertensive effect of prostacyclin. (1984) (2)
- Effect of glucocorticosteroids on the release of prostaglandin-like substances in anaphylaxis. (1977) (1)
- DIHOMO-γ- Linolenic Acid in Patients with Atherosclerosis ; Effects on Platelets, Plasma Lipids and LDL-Induced Inhibition of Prostacyclin Generation (1983) (1)
- Asthma and Anti-inflammatory Drugs (1983) (1)
- Anti-Platelet and Vasodilatory Action of Prostacyclin /PGI2/ in Healthy Men and in Patients with Peripheral Artery Disease (1979) (1)
- Bioassay of prostacyclin and endothelium‐derived relaxing factor (EDRF) from porcine aortic endothelial cells (1997) (1)
- Residual pulmonary neutrophils are involved in vaso- and bronchoconstrictor responses to platelet activating factor in the isolated buffer-perfused rat lung. (2000) (1)
- Prostacyclin in the therapy of peripheral arterial disease. (1980) (1)
- Pharmacological properties of a new beta-blocking agent (1-isopropylamino-3-(2-methyl-3-nitrophenoxy)-propan-2-ol). (1974) (1)
- Dihomo-γ-Linolenic Acid in Patients with Atherosclerosis: Effects on Platelet Aggregation, Plasma Lipids and Low-Density Lipoprotein-Induced Inhibition of Prostacyclin Generation (1984) (1)
- Clinical Use of Prostacyclin in Vascular Disease (1983) (1)
- A new circulatory hormone: prostacyclin. (1978) (1)
- [Almitrine, a powerful liberator of prostacyclin in vivo]. (1980) (0)
- [The lung, producer of prostacyclin]. (1980) (0)
- Dynamics of myocardial damage by isoprenaline in rats and an attempt to correlate the morphologic changes in the myocardium with electrocardiographic, biochemical and hematologic changes. (1971) (0)
- Controlled trials on the effects of prostacyclin in vascular disease (1984) (0)
- Evolution of ideas on the role of prostaglandins in inflammation. (1980) (0)
- Regulation of Prostacyclin (PGI2) Release into Circulation (1982) (0)
- Two main biological effects of prostacyclin, i.e., its effect (1983) (0)
- An experimental model of micronecrosis in the myocardium in rats. (1971) (0)
- Thrombolytic and Hypotensive Properties of Kallikrein in Anaesthetized Cats (1988) (0)
- [Effect of prostacyclin (PGI2) on retinal arteries]. (1984) (0)
- Aspirin, prostaglandins and bronchial asthma [proceedings]. (1978) (0)
- The influence of corticosteroids on prostaglandin release from various organs. (1978) (0)
- THE EFFECT OF SIX PROSTAGLANDINS, PROSTACYCLIN AND ILOPROST ON GENERATION OF SUPEROXIDE ANIONS (0J) BY HUMAN NEUTROPHILS (PMNs) ACTIVATED BY ZYMOSAN OR FMLP (1987) (0)
- [Effect of prostacycline aerosol on the activity of blood platelets and lungs]. (1979) (0)
- [Prostacyclin in ischemic stroke]. (1983) (0)
- Kallikrein-thrombolytic and hypotensive action in cats--preliminary results. (1990) (0)
- [Comparative studies on the damaging effect of catecholamines on rat myocardium]. (1976) (0)
- Selective inhibition by fenflumizole tissue cyclooxygenase in rabbits ex vivo. (1985) (0)
- Protection against isoprenaline induced myocardial necroses by beta-adrenergic blocking agents. (1973) (0)
- Effects of Two &bgr;3-Agonists, CGP 12177A and BRL 37344, on Coronary Flow and Contractility in Isolated Guinea Pig Heart (2003) (0)
- [1st intravenous administration of prostacyclin to man]. (1978) (0)
- A new endocrine-like function of lungs: generation of prostacyclin. (1978) (0)
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