R. Oss Jakes
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R. Oss Jakesbiology Degrees
Biology
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Neuroscience
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#2085
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Biology
R. Oss Jakes's Degrees
- PhD Neuroscience University of California, San Francisco
- Bachelors Biology Stanford University
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(Suggest an Edit or Addition)R. Oss Jakes's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- α-Synuclein in Lewy bodies (1997) (4852)
- Alpha-synuclein in Lewy bodies. (1997) (2847)
- α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies (1998) (2581)
- Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease (1989) (2149)
- alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies. (1998) (1031)
- Identification of two distinct synucleins from human brain (1994) (1025)
- Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans (1996) (918)
- Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease. (1988) (882)
- Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization. (1990) (835)
- Abnormal tau phosphorylation at Ser396 in alzheimer's disease recapitulates development and contributes to reduced microtubule binding (1993) (810)
- Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies (1998) (802)
- Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation. (2000) (708)
- Abundant Tau Filaments and Nonapoptotic Neurodegeneration in Transgenic Mice Expressing Human P301S Tau Protein (2002) (615)
- Binding of α-Synuclein to Brain Vesicles Is Abolished by Familial Parkinson’s Disease Mutation* (1998) (536)
- Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205 (1995) (530)
- Cingulin, a new peripheral component of tight junctions (1988) (504)
- Biophysical Properties of the Synucleins and Their Propensities to Fibrillate (2002) (463)
- Activation of the novel stress‐activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases (1997) (459)
- Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease. (1994) (458)
- Hypothesis: Microtubule Instability and Paired Helical Filament Formation in the Alzheimer Disease Brain Are Related to Apolipoprotein E Genotype (1994) (454)
- Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform. (1995) (438)
- The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development. (1993) (437)
- Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies. (1998) (409)
- Mutations causing neurodegenerative tauopathies. (2005) (389)
- Aggregates from mutant and wild‐type α‐synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of β‐sheet and amyloid‐like filaments (1998) (377)
- α-Synuclein Binds to Tau and Stimulates the Protein Kinase A-catalyzed Tau Phosphorylation of Serine Residues 262 and 356* (1999) (367)
- Synthetic filaments assembled from C‐terminally truncated α‐synuclein (1998) (354)
- Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau protein. (1994) (349)
- Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein (2000) (346)
- Detection of Phosphorylated Ser262 in Fetal Tau, Adult Tau, and Paired Helical Filament Tau (*) (1995) (334)
- The Synucleinopathies: Twenty Years On (2017) (307)
- The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase. (2001) (307)
- Phosphorylation of microtubule‐associated protein tau by stress‐activated protein kinases (1997) (298)
- Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of α‐synuclein protein implicated in Parkinson's disease (1998) (269)
- p42 map kinase phosphorylation sites in microtubule‐associated protein tau are dephosphorylated by protein phosphatase 2A1 Implications for Alzheimer's disease (1992) (264)
- Effects of frontotemporal dementia FTDP‐17 mutations on heparin‐induced assembly of tau filaments (1999) (255)
- Mutation E46K increases phospholipid binding and assembly into filaments of human α‐synuclein (2004) (240)
- A panel of epitope‐specific antibodies detects protein domains distributed throughout human α‐synuclein in lewy bodies of Parkinson's disease (2000) (212)
- A Raman optical activity study of rheomorphism in caseins, synucleins and tau. New insight into the structure and behaviour of natively unfolded proteins. (2002) (207)
- Difference between the tau protein of Alzheimer paired helical filament core and normal tau revealed by epitope analysis of monoclonal antibodies 423 and 7.51. (1991) (201)
- Active site titration and aminoacyl adenylate binding stoichiometry of aminoacyl-tRNA synthetases. (1975) (200)
- Staging of cytoskeletal and beta-amyloid changes in human isocortex reveals biphasic synaptic protein response during progression of Alzheimer's disease. (2000) (200)
- Alzheimer-like Changes in Microtubule-associated Protein Tau Induced by Sulfated Glycosaminoglycans (1997) (199)
- Tau Gene Mutation K257T Causes a Tauopathy Similar to Pick's Disease (2000) (166)
- Characterization of mAb AP422, a novel phosphorylation‐dependent monoclonal antibody against tau protein (1996) (165)
- Synthetic filaments assembled from C-terminally truncated alpha-synuclein. (1998) (158)
- AD2, a phosphorylation-dependent monoclonal antibody directed against tau proteins found in Alzheimer's disease. (1996) (152)
- Assembly of Alzheimer‐like filaments from full‐length tau protein (1994) (149)
- The microtubule binding repeats of tau protein assemble into filaments like those found in Alzheimer's disease (1992) (149)
- Protein Phosphatase 2A Is the Major Enzyme in Brain that Dephosphorylates τ Protein Phosphorylated by Proline‐Directed Protein Kinases or Cyclic AMP‐Dependent Protein Kinase (1995) (144)
- Mutation E46K increases phospholipid binding and assembly into filaments of human alpha-synuclein. (2004) (141)
- Binding of Abeta to alpha- and beta-synucleins: identification of segments in alpha-synuclein/NAC precursor that bind Abeta and NAC. (1997) (138)
- Identification of 3‐ and 4‐repeat tau isoforms within the PHF in Alzheimer's disease. (1991) (136)
- Tau protein is phosphorylated by cyclic AMP-dependent protein kinase and calcium/calmodulin-dependent protein kinase II within its microtubule-binding domains at Ser-262 and Ser-356. (1996) (135)
- Evidence that phosphorylation of the microtubule-associated protein Tau by SAPK4/p38δ at Thr50 promotes microtubule assembly (2005) (129)
- Fiber diffraction of synthetic a-synuclein filaments shows amyloid-like cross-b conformation (2000) (127)
- The primary structure of alamethicin. (1970) (117)
- Villin sequence and peptide map identify six homologous domains. (1988) (116)
- Demonstration of two reaction pathways for the aminoacylation of tRNA. Application of the pulsed quenched flow technique. (1975) (111)
- PTL-1, a microtubule-associated protein with tau-like repeats from the nematode Caenorhabditis elegans. (1996) (105)
- Epitope mapping of LB509, a monoclonal antibody directed against human α-synuclein (1999) (99)
- Reduced Binding of Protein Phosphatase 2A to Tau Protein with Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17 Mutations (2000) (95)
- Calcium binding regions of myosin ‘Regulatory’ light chains (1976) (87)
- Localization of the Alz-50 epitope in recombinant human microtubule-associated protein tau (1991) (86)
- Molecular dissection of the paired helical filament (1995) (85)
- Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease (1994) (83)
- Tyrosyl-tRNA synthetase from Escherichia coli. Stoichiometry of ligand binding and half-of-the-sites reactivity in aminoacylation. (1975) (83)
- Two‐Dimensional Characterization of Paired Helical Filament‐Tau from Alzheimer's Disease: Demonstration of an Additional 74‐kDa Component and Age‐Related Biochemical Modifications (1997) (81)
- Phosphorylation site sequence of smooth muscle myosin light chain (M r = 20 000) (1984) (73)
- Protein phosphatase 2A is the major enzyme in brain that dephosphorylates tau protein phosphorylated by proline-directed protein kinases or cyclic AMP-dependent protein kinase. (1995) (67)
- From genetics to pathology: tau and alpha-synuclein assemblies in neurodegenerative diseases. (2001) (62)
- Methionyl-tRNA synthetase from Escherichia coli. Primary structure of the active crystallised tryptic fragment. (2005) (61)
- Topographical relationship between beta-amyloid and tau protein epitopes in tangle-bearing cells in Alzheimer disease. (1990) (60)
- Sequence Determinants for Amyloid Fibrillogenesis of Human α-Synuclein (2007) (59)
- Different configurational states of beta-amyloid and their distributions relative to plaques and tangles in Alzheimer disease. (1990) (59)
- Tau gene (MAPT) sequence variation among primates. (2004) (56)
- Functional Characterization of FTDP-17 tau Gene Mutations through Their Effects on Xenopus Oocyte Maturation* (2002) (52)
- The amino acid sequence of profilin from calf spleen (1979) (50)
- A gelsolin-like Ca2+-dependent actin-binding domain in villin (1985) (48)
- Localisation of light chain and actin binding sites on myosin. (1986) (44)
- Molecular dissection of the neurofibrillary lesions of Alzheimer's disease. (1995) (44)
- Epitope mapping of LB509, a monoclonal antibody directed against human alpha-synuclein. (1999) (43)
- Repeated sequences in methionyl‐tRNA synthetase from E. coli (1974) (39)
- α‐Synuclein Inclusions in Alzheimer and Lewy Body Diseases (2000) (39)
- Tau protein in Alzheimer's disease. (1995) (39)
- Phosphorylation of tau by cyclic-AMP-dependent protein kinase. (1993) (38)
- Genetic dissection of familial Parkinson's disease. (1998) (37)
- Intraneuronal filamentous tau protein and α-synuclein deposits in neurodegenerative diseases (1998) (34)
- Amino acid sequence of myosin essential light chain from the scallop Aquipecten irradians. (1986) (34)
- Lewy Body Variant of Alzheimer's Disease: Selective Neocortical Loss of t-SNARE Proteins and Loss of MAP2 and α-Synuclein in Medial Temporal Lobe (2009) (32)
- Early‐onset Dementia with Lewy Bodies (2004) (30)
- Myosin-Linked Regulation: A Chemical Approach (1977) (29)
- Sequence Determinants for Amyloid Fibrillogenesis of Human alpha-Synuclein. (2007) (27)
- Regulatory and essential light-chain-binding sites in myosin heavy chain subfragment-1 mapped by site-directed mutagenesis. (1989) (26)
- Synuclein proteins of the pufferfish Fugu rubripes: sequences and functional characterization. (2006) (24)
- Binding of A β to α-and β-synucleins : identification of segments in α-synuclein / NAC precursor that bind A β and NAC (1997) (22)
- Mapping the cysteine residues and actin-binding regions of villin by using antisera to the amino and carboxyl termini of the molecule. (1985) (21)
- Parkinson's Disease, Dementia with Lewy Bodies, and Multiple System Atrophy as α-Synucleinopathies. (2001) (20)
- Gram-scale purification of methionyl-tRNA and tyrosyl-tRNA synthetases from Escherichia coli. (1975) (20)
- Intraneuronal filamentous tau protein and alpha-synuclein deposits in neurodegenerative diseases. (1998) (19)
- Tau protein and Alzheimer's disease (1994) (17)
- Human β-Synuclein Rendered Fibrillogenic by Designed Mutations (2010) (17)
- a-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies (ubiquitinysarkosyl-insoluble filamentsyimmunoelectron microscopy) (1998) (16)
- Activation of the novel MAP kinase homologue SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6). (1997) (15)
- Studies in the Respiratory and Carbohydrate Metabolism of Plant Tissues2 (1964) (15)
- The regulatory function of the myosin light chains (1976) (11)
- Role of the myosin light chains in the regulation of contractile activity. (1982) (10)
- Determination of Certain Phosphate Compounds in Plant Extracts (1962) (10)
- Characterisation of an Antibody Relevant to the Neuropathology of Alzheimer Disease (1995) (5)
- Post-translational modifications of microtubule-and growth-associated proteins in nerve regeneration and neuropathy (2009) (5)
- THE ABNORMAL PHOSPHORYLATION OF TAU AT SER396 IN ALZHEIMERʼS DISEASE RECAPITULATES PHOSPHORYLATION DURING DEVELOPMENT AND CONTRIBUTES TO REDUCED MICROTUBULE BINDING (1993) (3)
- Apolipoprotein E-e4 and apolipoprotein E-e2 are susceptibility genes that affect the rate of disease expressivity of late-onset familial and sporadic Alzheimer disease (1994) (2)
- Synthetic ¢laments assembled from C-terminally truncated K-synuclein (1998) (1)
- ReviewThe regulatory function of the myosin light chains (1976) (1)
- Pituitary fibroblast growth factors: immunocharacterization of an acid component and N-terminal sequence analysis of a truncated basic component. (1988) (1)
- Loss of synaptic proteins and choline acetyltransferase in primary and secondary visual cortex in dementia with Lewy bodies (2008) (0)
- 403 Characterization of mAb AP422, a novel phosphorylation-dependent monoclonal antibody against Tau protein (1996) (0)
- Screening of active ingredients for treatment of alzheimer's disease (1997) (0)
- Pituitary fgfs: characterization of acidic and basic forms (1989) (0)
- Topographical relationship between f 8-amyloid and tau protein epitopes in tangle-bearing cells in Alzheimer disease ( molecular pathology / amyloid fibrils / paired helical filaments ) (0)
- Screening of agents for the treatment of Alzheimer's disease (1997) (0)
- 303 Molecular dissection of the paired helical filament (1996) (0)
- Theabnormal phosphorylation oftauprotein atSer-202 in Alzheimer disease recapitulates phosphorylation during development (fetal tau/adult tau/paired helical fIlament/neuropathology) (1993) (0)
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