Jane Rylett
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Canadian molecular neurobiologist
Jane Rylett's AcademicInfluence.com Rankings
Jane Rylettbiology Degrees
Biology
#14901
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#18773
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Neuroscience
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World Rank
#2934
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Biology
Jane Rylett's Degrees
- PhD Neuroscience McGill University
Why Is Jane Rylett Influential?
(Suggest an Edit or Addition)According to Wikipedia, Rebecca Jane Rylett is a Canadian molecular neurobiologist. , she is the Scientific Director of the CIHR Institute of Aging. As a Distinguished University Professor at the University of Western Ontario, Rylett also served as an Associate Dean in the Schulich School of Medicine & Dentistry and chair of the Department of Physiology and Pharmacology.
Jane Rylett's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The Vesicular Acetylcholine Transporter Is Required for Neuromuscular Development and Function (2009) (121)
- The “ins” and “outs” of the high‐affinity choline transporter CHT1 (2006) (98)
- Overexpression of Pyruvate Dehydrogenase Kinase 1 and Lactate Dehydrogenase A in Nerve Cells Confers Resistance to Amyloid β and Other Toxins by Decreasing Mitochondrial Respiration and Reactive Oxygen Species Production* (2012) (85)
- The hemicholinium‐3 sensitive high affinity choline transporter is internalized by clathrin‐mediated endocytosis and is present in endosomes and synaptic vesicles (2003) (78)
- Amyloid‐beta oligomers increase the localization of prion protein at the cell surface (2011) (70)
- Constitutive high‐affinity choline transporter endocytosis is determined by a carboxyl‐terminal tail dileucine motif (2005) (68)
- Hippocampal choline acetyltransferase activity correlates with spatial learning in aged rats (1993) (67)
- Substrate binding and catalytic mechanism of human choline acetyltransferase. (2006) (49)
- Oligomeric aggregates of amyloid β peptide 1–42 activate ERK/MAPK in SH-SY5Y cells via the α7 nicotinic receptor (2009) (47)
- Phosphorylation of Rat Brain Choline Acetyltransferase and Its Relationship to Enzyme Activity (1993) (45)
- A model for dynamic regulation of choline acetyltransferase by phosphorylation (2005) (44)
- 82-kDa choline acetyltransferase is in nuclei of cholinergic neurons in human CNS and altered in aging and Alzheimer disease (2007) (41)
- Expression, purification and characterization of recombinant human choline acetyltransferase: phosphorylation of the enzyme regulates catalytic activity. (2000) (41)
- Phosphorylation of 69-kDa Choline Acetyltransferase at Threonine 456 in Response to Amyloid-β Peptide 1–42* (2003) (36)
- Regulated recycling and plasma membrane recruitment of the high‐affinity choline transporter (2007) (35)
- Identification of a Novel Nuclear Localization Signal Common to 69- and 82-kDa Human Choline Acetyltransferase* (2003) (32)
- Regulation of the high‐affinity choline transporter activity and trafficking by its association with cholesterol‐rich lipid rafts (2014) (31)
- Synaptosomal “Membrane‐Bound” Choline Acetyltransferase Is Most Sensitive to Inhibition by Choline Mustard (1989) (31)
- Protein Kinase C Isoforms Differentially Phosphorylate Human Choline Acetyltransferase Regulating Its Catalytic Activity* (2004) (26)
- Inhibitors of nitric oxide synthase attenuate nerve growth factor‐mediated increases in choline acetyltransferase expression in PC12 cells (2002) (25)
- Peroxynitrite Donor SIN-1 Alters High-Affinity Choline Transporter Activity by Modifying Its Intracellular Trafficking (2012) (24)
- Exposure of nuclear antigens in formalin-fixed, paraffin-embedded necropsy human spinal cord tissue: Detection of NeuN (2005) (23)
- The interaction between hexamethonium and tubocurarine on the rat neuromuscular junction (1984) (23)
- Into the Fourth Dimension: Dysregulation of Genome Architecture in Aging and Alzheimer’s Disease (2018) (22)
- Affinity Labelling and Identification of the High‐Affinity Choline Carrier from Synaptic Membranes of Torpedo Electromotor Nerve Terminals with [3H]Choline Mustard (1988) (21)
- Inhibitors of serine/threonine phosphatases increase membrane-bound choline acetyltransferase activity and enhance acetylcholine synthesis (1997) (21)
- Assessing the Severity of Perinatal Hypoxia-Ischemia in Piglets Using Near-Infrared Spectroscopy to Measure the Cerebral Metabolic Rate of Oxygen (2009) (21)
- Choline transporter CHT regulation and function in cholinergic neurons. (2012) (20)
- Rapid, transient effects of the protein kinase C activator phorbol 12-myristate 13-acetate on activity and trafficking of the rat high-affinity choline transporter (2010) (20)
- Nitrogen mustard analogues of choline: potential for use and misuse (1986) (18)
- Activity and Subcellular Trafficking of the Sodium-Coupled Choline Transporter CHT Is Regulated Acutely by Peroxynitrite (2008) (18)
- Choline mustard: an irreversible ligand for use in studies of choline transport mechanisms at the cholinergic nerve terminal. (1986) (18)
- Nuclear 82-kDa choline acetyltransferase decreases amyloidogenic APP metabolism in neurons from APP/PS1 transgenic mice (2014) (16)
- Surface-entropy reduction used in the crystallization of human choline acetyltransferase. (2005) (15)
- Uptake and metabolism of [3H]choline mustard by cholinergic nerve terminals from rat brain (1990) (15)
- Two methods for large-scale purification of recombinant human choline acetyltransferase. (2005) (13)
- 82-kDa choline acetyltransferase and SATB1 localize to β-amyloid induced matrix attachment regions (2016) (12)
- Amino-Terminal β-Amyloid Antibody Blocks β-Amyloid-Mediated Inhibition of the High-Affinity Choline Transporter CHT (2017) (10)
- Studies on the Alkylation of Choline Acetyltransferase by Choline Mustard Aziridinium Ion (1985) (9)
- Enhanced ubiquitination and proteasomal degradation of catalytically deficient human choline acetyltransferase mutants (2016) (9)
- Attenuation of Oxidative Stress in HEK 293 Cells by the TCM Constituents Schisanhenol, Baicalein, Resveratrol or Crocetin and Two Defined Mixtures. (2015) (9)
- Chaperone-Mediated Regulation of Choline Acetyltransferase Protein Stability and Activity by HSC/HSP70, HSP90, and p97/VCP (2017) (9)
- Differential regulation of the high‐affinity choline transporter by wild‐type and Swedish mutant amyloid precursor protein (2015) (8)
- Insulin Regulates the Activity of the High-Affinity Choline Transporter CHT (2015) (8)
- Identification and partial characterization of the high-affinity choline carrier from rat brain striatum. (1996) (6)
- Impact of Oxidative - Nitrosative Stress on Cholinergic Presynaptic Function (2011) (6)
- 121 EVIDENCE FOR HIGH AFFINITY CHOLINE TRANSPORT IN SYNAPTOSOMES PREPARED FROM HIPPOCAMPUS AND NEOCORTEX OF PATIENTS WITH ALZHEIMERʼS DISEASE (1983) (3)
- THE ROLE OF NEUROINFLAMMATION IN ALZHEIMER'S DISEASE (2016) (2)
- Solubilization and partial characterization of [3H]choline mustard-labeled high-affinity choline carrier from presynaptic plasma membrane of Torpedo electric organ. (1990) (2)
- Infiltrating Hematogenous Macrophages Aggregate Around β-Amyloid Plaques in an Age- and Sex-Dependent Manner in a Mouse Model of Alzheimer Disease. (2020) (2)
- Solubilization and partial characterization of [3H]choline mustard-labeled high-affinity choline carrier from presynaptic plasma membrane ofTorpedo electric organ (2008) (1)
- Characterization and attempted isolation of the high-affinity choline transporter of torpedo electromotor nerve-terminals using a radioactive choline azirdium analog. (1987) (1)
- P3-377 Abeta (1-42) peptide regulates phosphorylation of nuclear choline acetyltransferase at threonine-456 by p38 kinase (2006) (0)
- SPAAC Pulse-Chase: A Novel Click Chemistry-Based Method to Determine the Half-Life of Cellular Proteins (2021) (0)
- Quantitative Cerebral Metabolism Measurements with NIRS: Application to Neonatal Brain Injury (2008) (0)
- P1-190 Oligomeric amyloid-β 1–42 activates extracellular signal regulated kinases ERK1 and ERK2 of the mitogen activated protein kinase pathway in SH-SY5Ycells (2004) (0)
- P1-390 Galantamine effects on activity and phosphorylation of choline acetyltransferase: alterations in regulation of acetylcholine biosynthesis (2004) (0)
- P4-177 Hierarchical phosphorylation of choline acetyltransferase by protein kinase-C and regulation of its enzymatic activity (2004) (0)
- CREATION OF THE CANADIAN CONSORTIUM FOR NEURODEGENERATION IN AGING (2014) (0)
- A novel transgenic mouse model expressing primate-specific nuclear choline acetyltransferase: insights into potential cholinergic vulnerability (2023) (0)
- Terminalsat Vesamicol-Treated Motor Nerve Empty Synaptic Vesicles Recycle and Undergo (2015) (0)
- Regulation of the high-affinity choline transporter activity and trafficking by its association with lipid rafts (2013) (0)
- Structures of ligand bound human choline acetyltransferase provide insight into regulation of acetylcholine synthesis (2006) (0)
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