Ryuichi Kato
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Molecular Biology
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Biochemistry
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Biology
Ryuichi Kato's Degrees
- PhD Biochemistry University of Tokyo
- Masters Biochemistry University of Tokyo
- Bachelors Biochemistry University of Tokyo
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(Suggest an Edit or Addition)Ryuichi Kato's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- EFFECT OF STARVATION ON NADPH-DEPENDENT ENZYMES IN LIVER MICROSOMES OF MALE AND FEMALE RATS (1965) (518)
- Sex differences in the effects of abnormal physiological states on the metabolism of drugs by rat liver microsomes. (1965) (244)
- Sex difference of cytochrome P-450 in the rat: purification, characterization, and quantitation of constitutive forms of cytochrome P-450 from liver microsomes of male and female rats. (1983) (219)
- Drug metabolism under pathological and abnormal physiological states in animals and man. (1977) (203)
- Metabolic activation and covalent binding to nucleic acids of carcinogenic heterocyclic amines from cooked foods and amino acid pyrolysates. (1987) (172)
- Sex-specific cytochrome P450 as a cause of sex- and species-related differences in drug toxicity. (1992) (162)
- Suppression of levels of phenobarbital-inducible rat liver cytochrome P-450 by pituitary hormone. (1987) (159)
- Age-related alteration in the activities of drug-metabolizing enzymes and contents of sex-specific forms of cytochrome P-450 in liver microsomes from male and female rats. (1985) (149)
- Purification and properties of cytochrome P-450 from homogenates of human fetal livers. (1985) (136)
- Structural similarity and diversity of sulfotransferases. (1994) (128)
- Characteristics of nitro reduction of the carcinogenic agent, 4-nitroINOLONE N-oxide. (1970) (123)
- Cytochrome P450 in livers of diabetic rats: regulation by growth hormone and insulin. (1989) (116)
- Toxicity and metabolism of drugs in relation to dietary protein. (1968) (113)
- A high-spin form of cytochrome P-450 highly purified from polychlorinated biphenyl-treated rats. Catalytic characterization and immunochemical quantitation in liver microsomes. (1983) (111)
- Cytochrome P450 mediated metabolism of diazepam in human and rat: involvement of human CYP2C in N-demethylation in the substrate concentration-dependent manner. (1993) (108)
- Microsomal activation of 2-amino-3-methylimidazo[4,5-f]quinoline, a pyrolysate of sardine and beef extracts, to a mutagenic intermediate. (1983) (108)
- Metabolic activation of mutagenic N-hydroxyarylamines by O-acetyltransferase in Salmonella typhimurium TA98. (1985) (108)
- Effect of phenobarbital on electron transport system, oxidation and reduction of drugs in liver microsomes of rats of different age. (1968) (102)
- Isolation and expression of a cDNA encoding a male-specific rat sulfotransferase that catalyzes activation of N-hydroxy-2-acetylaminofluorene. (1993) (101)
- Genetic polymorphisms in human liver phenol sulfotransferases involved in the bioactivation of N-hydroxy derivatives of carcinogenic arylamines and heterocyclic amines. (1998) (97)
- Cloning and sequence analysis of a rat liver cDNA encoding hydroxysteroid sulfotransferase. (1989) (96)
- Effect of growth hormone and ectopic transplantation of pituitary gland on sex-specific forms of cytochrome P-450 and testosterone and drug oxidations in rat liver. (1986) (92)
- Cytochrome P-450 as a determinant of sex difference of drug metabolism in the rat. (1982) (92)
- Differences among the action of phenobarbital, methylcholanthrene and male sex hormone on microsomal drug-metabolizing enzyme systems of rat liver. (1966) (90)
- Dopamine receptor blocking activity of sulpiride in the central nervous system. (1977) (90)
- Possible role of P-450 in the oxidation of drugs in liver microsomes. (1966) (88)
- cDNA cloning of the hydroxysteroid sulfotransferase STa sharing a strong homology in amino acid sequence with the senescence marker protein SMP-2 in rat livers. (1990) (88)
- Effect of tyrosine kinase inhibition by imatinib mesylate on mast cell tumors in dogs. (2008) (87)
- Metabolism of drugs in old rats. I. Activities of NADPH-linked electron transport and drug-metabolizing enzyme systems in liver microsomes of old rats. (1968) (86)
- Nucleotide sequence of a full-length cDNA (PST-1) for aryl sulfotransferase from rat liver (1990) (85)
- N-hydroxylation of carcinogenic and mutagenic aromatic amines. (1983) (85)
- Mechanism of activation of proximate mutagens in Ames' tester strains: the acetyl-CoA dependent enzyme in Salmonella typhimurium TA98 deficient in TA98/1,8-DNP6 catalyzes DNA-binding as the cause of mutagenicity. (1983) (83)
- Activation of 2‐Hydroxyamino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridne by cDNA‐expressed Human and Rat Arylsulfotransferases (1994) (81)
- Metabolism of drugs in old rats. II. Metabolism in vivo and effect of drugs in old rats. (1968) (80)
- Studies on the mechanism of nitro reduction by rat liver. (1969) (76)
- Isolation and characterization of active metabolites of tryptophan-pyrolysate mutagen, TRP-P-2, formed by rat liver microsomes. (1980) (74)
- Purification and characterization of four catalytically active testosterone 6 beta-hydroxylase P-450s from rat liver microsomes: comparison of a novel form with three structurally and functionally related forms. (1990) (73)
- Sex difference in the O-dealkylation activity of 7-hydroxycoumarin O-alkyl derivatives in liver microsomes of rats. (1980) (71)
- A sex-specific form of cytochrome P-450 catalyzing propoxycoumarin O-depropylation and its identity with testosterone 6 beta-hydroxylase in untreated rat livers: reconstitution of the activity with microsomal lipids. (1988) (70)
- Drug metabolism in tumor-bearing rats. I. Activities of NADPH-linked electron transport and drug-metabolizing enzyme systems in liver microsomes of tumor-bearing rats. (1968) (68)
- Cytochrome b5 potentiation of cytochrome P-450 catalytic activity demonstrated by a vaccinia virus-mediated in situ reconstitution system. (1990) (64)
- Primary structures and properties of two related forms of aryl sulfotransferases in human liver. (1995) (63)
- Participation of cytochrome P-450 in reductive metabolism of 1-nitropyrene by rat liver microsomes. (1984) (63)
- Studies on the mechanism of drug-induced microsomal enzyme activities. V. Phenobarbital stimulation of endogenous messenger RNA and polyuridylic acid-directed L-[14C]-phenylalanine incorporation. (1966) (62)
- Metabolic activation of a protein pyrolysate promutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline by rat liver microsomes and purified cytochrome P-450. (1988) (62)
- Lack of low Km diazepam N-demethylase in livers of poor metabolizers for S-mephenytoin 4'-hydroxylation. (1994) (61)
- Gene conversion and differential regulation in the rat P-450 IIA gene subfamily. Purification, catalytic activity, cDNA and deduced amino acid sequence, and regulation of an adult male-specific hepatic testosterone 15 alpha-hydroxylase. (1988) (60)
- A new cytochrome P450 form belonging to the CYP2D in dog liver microsomes: purification, cDNA cloning, and enzyme characterization. (1995) (60)
- Metabolism and activation of aflatoxin B1 by reconstituted cytochrome P-450 system of rat liver. (1980) (59)
- Difference in the susceptibility of two phenobarbital-inducible forms, P450IIB1 and P450IIB2, to thyroid hormone- and growth hormone-induced suppression in rat liver: phenobarbital-inducible P450IIB2 suppression by thyroid hormone acting directly, but not through the pituitary system. (1991) (59)
- Pituitary regulation of sex-specific forms of cytochrome P-450 in liver microsomes of rats. (1985) (58)
- Postnatal development of constitutive forms of cytochrome P-450 in liver microsomes of male and female rats. (1984) (57)
- Metabolic activation of glutamic acid pyrolysis products, 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole and 2-amino-dipyrido[1,2-a:3',2'-d]imidazole, by purified cytochrome P-450. (1981) (57)
- Purification of human liver cytochrome P-450 catalyzing testosterone 6 beta-hydroxylation. (1987) (56)
- Polymorphism in hydroxylation of mephenytoin and hexobarbital stereoisomers in relation to hepatic P‐450 human‐2 (1990) (55)
- Microsome-specific stimulation by phenobarbital of amino acid incorporation in vivo. (1965) (54)
- Acetyl coenzyme A dependent activation of N-hydroxy derivatives of carcinogenic arylamines: mechanism of activation, species difference, tissue distribution, and acetyl donor specificity. (1986) (53)
- Effects of starvation and refeeding on the oxidation of drugs by liver microsomes. (1967) (53)
- Metabolic activation of mutagenic tryptophan pyrolysis products by rat liver microsomes. (1980) (53)
- Thyroid hormone and activities of drug-metabolizing enzymes and electron transport systems of rat liver microsomes. (1968) (53)
- Mutagenic activation of aflatoxin B1 by several forms of purified cytochrome P-450. (1986) (52)
- Reduction of tertiary amine N-oxides by liver microsomal cytochrome P-450. (1976) (52)
- Evidence for the involvement of cytochrome P-450 in tiaramide N-oxide reduction. (1974) (51)
- Effect of vitamin C deficiency on the metabolism of drugs and NADPH-linked electron transport system in liver microsomes. (1969) (50)
- Effects of hypophysectomy and growth hormone treatment on sex-specific forms of cytochrome P-450 in relation to drug and steroid metabolisms in rat liver microsomes. (1986) (50)
- Suppression in the expression of a male-specific cytochrome P450, P450-male: difference in the effect of chemical inducers on P450-male mRNA and protein in rat livers. (1989) (49)
- Nucleotide sequence of a human liver cytochrome P-450 related to the rat male specific form. (1987) (49)
- Thyroid hormone suppression of hepatic levels of phenobarbital-inducible P-450b and P-450e and other neonatal P-450s in hypophysectomized rats. (1989) (48)
- Hormonal regulation of rat renal cytochrome P450s by androgen and the pituitary. (1992) (48)
- Expression of a human P-450IIC gene in yeast cells using galactose-inducible expression system. (1989) (47)
- Activation and detoxication of N-hydroxy-Trp-P-2 by glutathione and glutathione transferases. (1983) (47)
- Human CYP2C-mediated stereoselective phenytoin hydroxylation in Japanese: difference in chiral preference of CYP2C9 and CYP2C19. (1999) (46)
- Partial purification and characterization of cytochrome P-450 responsible for the occurrence of sex difference in drug metabolism in the rat. (1981) (46)
- The regulation by growth hormone of microsomal testosterone 6 beta-hydroxylase in male rat livers. (1986) (45)
- Studies on age difference in mice for the activity of drug-metabolizing enzymes of liver microsomes. (1970) (44)
- Evidence for the involvement of multiple forms of cytochrome P-450 in the occurrence of sex-related differences of drug metabolism in the rat. (1982) (44)
- Evidence for the involvement of N-hydroxylation of 3-amino-1-methyl-5H-pyrido[4,3-b]indole by cytochrome P-450 in the covalent binding to DNA. (1981) (44)
- N-hydroxyarylamine O-acetyltransferase in hamster liver: identity with arylhydroxamic acid N,O-acetyltransferase and arylamine N-acetyltransferase. (1986) (43)
- Metabolic activation of N-hydroxylated metabolites of carcinogenic and mutagenic arylamines and arylamides by esterification. (1994) (43)
- Metabolic activation of mutagenic tryptophan pyrolysis products (Trp-P-1 and Trp-P-2) by a purified cytochrome P-450-dependent monooxygenase system. (1980) (43)
- Species difference in N-hydroxylation of a tryptophan pyrolysis product in relation to mutagenic activation. (1981) (43)
- Suppression of hepatic levels of an ethanol-inducible P-450DM/j by growth hormone: relationship between the increased level of P-450DM/j and depletion of growth hormone in diabetes. (1989) (42)
- Effect of administration of 3-aminotriazole on the activity of microsomal drug-metabolizing enzyme systems of rat liver. (1967) (42)
- Regulation of hepatic cortisol sulfotransferase in rats by pituitary growth hormone. (1989) (42)
- Regulation of hepatic sulfotransferase catalyzing the activation of N-hydroxyarylamide and N-hydroxyarylamine by growth hormone. (1987) (42)
- Hepatic triiodothyronine sulfation and its regulation by growth hormone and triiodothyronine in rats. (1992) (42)
- Evidence for the involvement of cytochrome P-450 in reduction of benzo(a)pyrene 4,5-oxide by rat liver microsomes. (1976) (42)
- Sulfotransferase-mediated DNA binding of N-hydroxyarylamines(amide) in liver cytosols from human and experimental animals. (1992) (41)
- Species differences in stereoselective metabolism of mephenytoin by cytochrome P450 (CYP2C and CYP3A). (1993) (41)
- Enzymatic acetylation and sulfation of N-hydroxyarylamines in bacteria and rat livers. (1989) (41)
- Metabolic Activation of Pyrolysate Arylamines by Human Liver Microsomes; Possible Involvement of a P‐448‐H Type Cytochrome P‐450 (1988) (41)
- Syntheses of hydroxyamino, nitroso and nitro derivatives of Trp-P-2 and Glu-P-1, amino acid pyrolysate mutagens, and their direct mutagenicities towards Salmonella typhimurium TA98 and TA98NR. (1983) (40)
- Drug metabolism in tumor-bearing rats. II. In vivo metabolisms and effects of drugs in tumor-bearing rats. (1968) (40)
- Monomorphic and polymorphic isozymes of arylamine N-acetyltransferases in hamster liver: purification of the isozymes and genetic basis of N-acetylation polymorphism. (1990) (39)
- SPECIES DIFFERENCE IN DRUG METABOLISM BY LIVER MICROSOMES IN ALLOXAN DIABETIC OR FASTED ANIMALS:(I) THE ACTIVITY OF DRUG-METABOLIZING ENZYMES AND ELECTRON TRANSPORT SYSTEM (1970) (37)
- Enhancement of Binding of N-Hydroxy-TRP-P-2 to DNA by seryl-tRNA synthetase. (1981) (36)
- Hormonal Regulation of Cytochrome P450 in Rat Liver (1993) (36)
- Complete cDNA sequence of a major 3-methylcholanthrene-inducible cytochrome P-450 isozyme (P-450AFB) of Syrian hamsters with high activity toward aflatoxin B1. (1989) (36)
- Metabolic activation of 2-amino-9H-pyrido[2,3-b]indole by rat-liver microsomes. (1982) (36)
- Transcriptional Elements Directing a Liver-Specific Expression of P450/6βA (CYP3A2) Gene-Encoding Testosterone 6β-Hydroxylase (1995) (35)
- Role of growth hormone in modulating the constitutive and phenobarbital-induced levels of two P-450(6)beta (testosterone 6 beta-hydroxylase) mRNAs in rat livers. (1989) (35)
- Studies on the mechanism of sex difference in drug-oxidizing activity of liver microsomes. (1968) (35)
- Specificity of four forms of cytochrome P-450 in the metabolic activation of several aromatic amines and benzo[a]pyrene. (1984) (35)
- Properties of cutaneous acetyltransferase catalyzing N- and O-acetylation of carcinogenic arylamines and N-hydroxyarylamine. (1988) (35)
- Purification of hepatic N-hydroxyarylamine sulfotransferases and their regulation by growth hormone and thyroid hormone in rats. (1991) (34)
- DNA binding of N-hydroxy-Trp-P-2 and N-hydroxy-Glu-P-1 by acetyl-CoA dependent enzyme in mammalian liver cytosol. (1985) (34)
- The importance of substrate concentration in determining cytochromes P450 therapeutically relevant in vivo. (1994) (33)
- High capacity of human skin for N-acetylation of arylamines. (1990) (33)
- Species differences in the N-acetylation by liver cytosol of mutagenic heterocyclic aromatic amines in protein pyrolysates. (1984) (33)
- Catalysis of the covalent binding of 3-hydroxyamino-1-methyl-5H-pyrido[4,3-b]indole to DNA by a L-proline- and adenosine triphosphate-dependent enzyme in rat hepatic cytosol. (1985) (33)
- Induced Increase of Meprobamate Metabolism in Rats Treated with Phenobarbital or Phenaglycodol (1960) (32)
- Covalent binding of N-hydroxy-Trp-P-2 to DNA by cytosolic proline-dependent system. (1982) (32)
- cDNA and deduced amino acid sequences of human P450 IIA3 (CYP2A3). (1989) (31)
- Structure of a Gene and cDNA of a Major Constitutive Form of Testosterone 6β-Hydroxylase (P450/6βA) Encoding CYP3A2: Comparison of the cDNA with P450PCN2 (1994) (31)
- Inhibition of drug-metabolizing enzymes of liver microsomes by hydrazine derivatives in relation to their lipid solubility. (1969) (30)
- Isolation and characterization of a new rat P450 (CYP3A18) cDNA encoding P450(6)beta-2 catalyzing testosterone 6 beta- and 16 alpha-hydroxylations. (1996) (30)
- Increased Sensitivity of Microsomes from Phenobarbital-Treated Rats to Synthetic Messenger RNA (Polyuridylic Acid): Lack of Effect on Ribosomes (1965) (30)
- Effect of starvation on the in vivo metabolism and effect of drugs in female and male rats. (1967) (29)
- Effect of growth hormone on rat hepatic cytochrome P-450f mRNA: a new mode of regulation (1990) (29)
- Effects of phenobarbital, 3-methylcholanthrene and polychlorinated biphenyls on sex-specific forms of cytochrome P-450 in liver microsomes of rats. (1986) (29)
- Modulation of hepatic level of microsomal testosterone 7 alpha-hydroxylase, P-450a (P450IIA), by thyroid hormone and growth hormone in rat liver. (1990) (29)
- Reduction of tertiary amine N-oxides by cytochrome P-450. Mechanism of the stimulatory effect of flavins and methyl viologen. (1978) (28)
- Immunochemical examinations of cytochrome P-450 in various tissues of human fetuses using antibodies to human fetal cytochrome P-450, P-450 HFLa. (1985) (27)
- An arylamine acetyltransferase (AT‐I) from syrian golden hamster liver: Cloning, complete nucleotide sequence, and expression in mammalian cells (1991) (27)
- Alteration of hepatic drug metabolizing activities and contents of cytochrome P-450 isozymes by neonatal monosodium glutamate treatment. (1988) (26)
- Substrate-induced spectral change of liver microsomes in phenobarbital and methylcholanthrene-treated male and female rats. (1970) (26)
- Effect of adrenalectomy or alloxan diabetes on the substrate interaction with cytochrome P-450 in the oxidation of drugs by liver microsomes. (1971) (25)
- Further studies on the persistence of neonatal androgen imprinting on sex-specific cytochrome P-450, testosterone and drug oxidations. (1987) (24)
- Effects of morphine treatment and starvation on the substrate interaction with P-450 in the oxidation of drugs by liver microsomes. (1970) (24)
- Metabolism of carcinogenic compounds. I. Effect of phenobarbital and methylcholanthrene on the activities of N-demethylation of carcinogenic compounds by liver microsomes of male and female rats. (1967) (24)
- Studies on the regulation of the activity of drug oxidation in rat liver microsomes by androgen and estrogen. (1970) (24)
- Neonatal testosterone imprinting of hepatic microsomal drug metabolism and a male-specific form of cytochrome P-450 in the rat. (1984) (23)
- Primary structure and molecular basis of polymorphic appearance of an acetyltransferase (AT-II)* in hamsters. (1994) (23)
- Reduction of tertiary amine N-oxide by purified cytochrome P-450. (1977) (23)
- The apparent loss of cytochrome P-450 associated with metabolic activation of carbon tetrachloride. (1979) (22)
- Disposition and enterohepatic circulation of diclofenac in dogs. (1980) (22)
- Effect of morphine administration on the hydroxylation of steroid hormones by rat liver microsomes. (1970) (22)
- Species differences in the effect of morphine administration or adrenalectomy on the substrate interactions with cytochrome P-450 and drug oxidations by liver microsomes. (1971) (22)
- Effect of thyroid hormone on the substrate interaction with P-450 in the oxidation of drugs by liver microsomes. (1970) (22)
- Effects of thyroxine and thyroidectomy on the hydroxylation of testosterone by liver microsomes from male and female rats. (1970) (22)
- Cytochrome P-450 human-2 (P-450IIC9) in mephenytoin hydroxylation polymorphism in human livers: differences in substrate and stereoselectivities among microheterogeneous P-450IIC species expressed in yeasts. (1991) (21)
- Reduction of epoxy derivatives of benzo(a)pyrene by microsomal cytochrome P-450. (1980) (20)
- Specificity of hepatic cytochrome P-450 isoenzymes from PCB-treated rats and participation of cytochrome b5 in the activation of aflatoxin B1. (1983) (20)
- Strain differences in the metabolism and action of drugs in mice and rats. (1970) (20)
- Formation of 2‐Amino‐3‐methylimidazo[4,5‐f]quinoline‐ and 2‐Amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline‐sulfamates by cDNA‐expressed Mammalian Phenol Sulfotransferases (1995) (19)
- Effects of ascorbic acid on the nonenzymatic binding to DNA and the mutagenicity of N-hydroxylated metabolite of a tryptophan-pyrolysis product. (1982) (19)
- Differences in the oxidative metabolism of drugs by liver microsomes. (1969) (19)
- Age- and sex-related alterations of microsomal drug- and testosterone-oxidizing cytochrome P450 in Sprague-Dawley strain-derived dwarf rats. (1995) (18)
- Expression and functional characterization of a rat sulfotransferase (ST1A1) cDNA for sulfations of phenolic substrates in COS-1 cells. (1993) (18)
- [Decreased hydroxylation of steroid hormones by liver microsomes from rats bearing Walker carcinosarcoma 256]. (1970) (18)
- Hepatic microsomal tolbutamide hydroxylation in Japanese: in vitro evidence for rapid and slow metabolizers. (1993) (18)
- Effect of toxohormone on microsomal cytochromes and hydroxylating systems of rat liver. (1969) (17)
- Effect of norharman on DNA strand breaks and mutation of Chinese hamster V79 cells by chemical carcinogens. (1984) (17)
- Reduction of N-hydroxy-2-acetylaminofluorene by liver microsomes. (1980) (17)
- The mechanism of sex differences in the anesthetic action of progesterone in rats. (1971) (16)
- Stimulatory effect of FMN and methyl viologen on cytochrome P-450 dependent reduction of tertiary amine N-oxide. (1976) (16)
- Isolation and characterization of four cytochrome P450 isozymes from untreated and phenobarbital-treated beagle dogs. (1994) (16)
- A high spin form of cytochrome P-448 highly purified from PCB-treated rats--II. Characteristic requirement of cytochrome b5 for maximum activity. (1983) (15)
- Species difference in the inhibition of drug metabolism by liver microsomes by different inhibitors. (1969) (15)
- A gene structure of testosterone 6β-hydroxylase (P450IIIA) (1991) (15)
- Metabolic activation of Trp-P-2, a tryptophan-pyrolysis mutagen, by isolated rat hepatocytes. (1983) (15)
- A sensitive method for determination of biphenyl hydroxylase activities using high-performance liquid chromatography. (1981) (15)
- Effect of androgen and estrogen on the hydroxylation of steroid hormones by rat liver microsomes. (1969) (15)
- Effect of phenobarbital and methylcholanthrene treatment on drug-induced difference spectrum of liver microsomes. (1969) (15)
- Distinct effects of phenobarbital and its N-methylated derivative on liver cytochrome P450 induction. (1996) (15)
- Glutathione transferase-mediated and non-enzymatic activation and detoxication of the N-hydroxy derivative of Trp-P-2, a potent pyrolysate promutagen. (1984) (14)
- Transcriptional elements directing a liver-specific expression of P450/6 beta A (CYP3A2) gene-encoding testosterone 6 beta-hydroxylase. (1995) (14)
- Species differences in metabolism of tiaramide hydrochloride, a new anti-inflammatory agent. (1977) (14)
- Species differences in the alteration of drug-metabolizing activities of liver microsomes by thyroxine treatment. (1969) (14)
- Effect of phenobarbital treatment on the activities of NADPH-dependent enzymes of liver microsomes in fasting or sucrose-fed rats. (1967) (14)
- Stereoselective oxidation and plasma protein binding of nilvadipine, a new dihydropyridine calcium antagonist, in man. (1988) (14)
- Antitumor effect and metabolic activation of cyclophosphamide and 4-hydroperoxycyclophosphamide in the human breast carcinoma (MX-1)-nude mouse system. (1983) (13)
- Monoclonal antibodies against a high spin form of rat cytochrome P-448. (1985) (13)
- Inhibition of benzodiazepine and GABA receptor binding by amino-gamma-carbolines and other amino acid pyrolysate mutagens. (1984) (13)
- Metabolic activation of a tryptophan pyrolysis product, 3-amino-1-methyl-5H-pyrido[4,3-b]indole(TRP-P-2) by isolated rat liver nuclei. (1981) (13)
- Structural elucidation of a mutagenic metabolite of 3-amino-1-methyl-5H-pyrido[4,3-b]indole. (1981) (13)
- Effect of morphine administration on the activities of microsomal drug-metabolizing enzyme systems in liver of different species. (1966) (13)
- Metabolic activation of trp-P-2, a mutagenic amine from tryptophan-pyrolysate, by liver microsomes from 3-methylcholanthrene-responsive and non-responsive mice. (1980) (13)
- Drug oxidation activities of horseradish peroxidase, myoglobin and cytochrome P-450cam reconstituted with synthetic hemes. (1987) (13)
- Reduction of tertiary amine N-oxides by rat liver mitochondria. (1977) (13)
- Studies on in vitro antipyrine metabolism by 13C,15N double labeled method. (1987) (12)
- Disposition and metabolic fate of tiaramide hydrochloride, a new anti-inflammatory agent, in the rat. (1977) (12)
- Interactions between the active metabolite of tryptophan pyrolysate mutagen, N-hydroxy-Trp-P-2, and lipids: the role of lipid peroxides in the conversion of N-hydroxy-Trp-P-2 to non-reactive forms. (1983) (12)
- DNA single-strand breaks by nitropyrenes and related compounds in Chinese hamster V79 cells. (1984) (12)
- A new assay for N-hydroxyarylamine O-acetyltransferase: reduction of N-hydroxyarylamines through N-acetoxyarylamines. (1986) (12)
- Suppression of clofibrate-induction of peroxisomal and microsomal fatty acid-oxidizing enzymes by growth hormone and thyroid hormone in primary cultures of rat hepatocytes. (1995) (12)
- Reconstitution of benzo[a] pyrene 4,5‐oxide reductase activity by purified cytochrome P‐450 (1978) (12)
- Species and sex differences in the substrate-induced spectral change of P-450 in relation to the activity of drug oxidation in liver microsomes. (1970) (11)
- Analysis and differentiation of the mechanism in the development of drug tolerance. (1967) (11)
- Activation and inactivation of a variety of mutagenic compounds by the reconstituted system containing highly purified preparations of cytochrome P-450 from rat liver (1985) (11)
- A new Salmonella tester strain expressing a hamster acetyltransferase shows high sensitivity for arylamines. (1993) (11)
- Different effect of aflatoxin on the induction of tryptophan oxygenase and of microsomal drug-hydroxylase system. (1970) (11)
- Mechanism of thyroxine-induced increase in steroid delta4-reductase activity in male rats. (1970) (11)
- SPECIES DIFFERENCE IN DRUG METABOLISM BY LIVER MICROSOMES IN ALLOXAN DIABETIC OR FASTED ANIMALS (II) THE SUBSTRATE INTERACTION WITH CYTOCHROME P-450 IN DRUG OXIDATION (1970) (11)
- Comparative study on the metabolism of N-methyl-4-aminoazobenzene by two forms of cytochrome P-488. (1985) (10)
- Inhibition of acetyl-coenzyme A dependent activation of N-hydroxyarylamines by phenolic compounds, pentachlorophenol and 1-nitro-2-naphthol. (1986) (10)
- Effect of syrup on the absorption of drugs from gastrointestinal tract. (1969) (10)
- Isolation and characterization of human liver cytochrome b5 cDNA. (1989) (10)
- Characterization and expression of hepatic sulfotransferase involved in the metabolism of N-substituted aryl compounds. (1994) (10)
- cDNA and deduced amino acid sequences of a male dominant P-450Md mRNA in rats. (1990) (10)
- Polymorphism in stereoselective hydroxylations of mephenytoin and hexobarbital by Japanese liver samples in relation to cytochrome P-450 human-2 (IIC9). (1992) (9)
- Individual difference in the effect of drugs in relation to the tissue concentration of drugs. (1969) (9)
- Decrease in the substrate interaction with cytochrome P-450 in drug hydroxylation by liver microsomes from rats bearing Walker 256 carcinosarcoma. (1970) (9)
- Activation and detoxication of carcinogenic arylamines by sulfation. (1995) (9)
- Effects of thyroid hormone on the hydroxylation of progesterone in liver microsomes of male and female rats. (1970) (9)
- Sex difference in the activities of microsomal drug-metabolizing enzyme systems in relation to dietary protein. (1966) (9)
- Metabolism of tiaramide in vitro. I. Oxidative metabolism of tiaramide by human and rat liver microsomes. (1982) (9)
- Species and sex differences in aminopyrine N-demethylating activity of liver microsomes under unphysiological conditions. (1968) (9)
- Effect of aflatoxin B1 on the incorporation of14C-acetate into cholesterol by rat liver (1969) (9)
- Modulation of ethanol-mediated CYP2E1 induction by clofibrate and L-carnitine in rat liver. (1993) (8)
- Inhibition by SKF 525-A of 7-ethoxycoumarin O-deethylation in microsomal and the reconstituted monooxygenase systems from PCB-treated rat livers. (1980) (8)
- Fast-atom bombardment and electron-impact mass spectrometry of N-hydroxyarylamines, active intermediates of mutagenic aromatic amines. (1985) (8)
- Activation and inactivation of a variety of mutagenic compounds by the reconstituted system containing highly purified preparations of cytochrome P-450 from rat liver. (1985) (8)
- Effect of phenobarbital on biosynthesis and elimination of cholesterol in rats. (1968) (8)
- Effect of phenobarbital on the activities of drug-metabolizing enzymes and electron transport system of liver microsomes in alloxan diabetes and thyroxine treated rats. (1969) (8)
- Molecular mechanisms of polymorphism in acetylating enzymes for arylamines and N-hydroxyarylamines in hamster liver. (1995) (7)
- Drug affecting the gastric emptying rate and drug absorption. (1972) (7)
- Induction of cytochrome P-450c and P-450d by metyrapone in the primary culture of rat hepatocytes. (1989) (7)
- Effect of adrenalectomy on the substrate interaction with cytochrome P-450 in the hydroxylation of steroid hormones by liver microsomes. (1970) (7)
- Characterization of human P450IIC isozymes by using yeast expression system. (1991) (6)
- Enhancement by cysteinyl thiols of acetyltransferase-mediated, but not of sulfotransferase-mediated, binding of a pyrolysate-derived N-hydroxyarylamine, 2-hydroxyamino-6-methyldipyrido[1,2-a:3',2'-d]imidazole, to DNA. (1990) (6)
- Decrease in the activity of hepatic microsomal drug-metabolizing enzymes in tumor-bearing nude mice. (1982) (6)
- Intracellular localization and co-factor requirement of nitroreductase in rat liver. (1968) (6)
- Hydroxylation of steroid hormone by the liver microsomes of rats under pathological states. (1968) (6)
- IMPORTANCE OF PURIFICATION OF HEPATIC CYTOCHROME P-450 FOR STUDYING DRUG METABOLISM IN MAN (1980) (6)
- Factors affecting the toxicity and metabolism of OMPA (octamethylpyrophosphoramide) in rats. (1967) (6)
- STUDIES ON SEX DIFFERENCES IN THE O-DEALKYLATION ACTIVITIES OF 7-HYDROXYCOUMARIN O-ALKYL DERIVATIVES IN LIVER MICROSOMES OF RATS (1980) (5)
- Structure of a gene and cDNA of a major constitutive form of testosterone 6 beta-hydroxylase (P450/6 beta A) encoding CYP3A2: comparison of the cDNA with P450PCN2. (1994) (5)
- Substrate interaction with P-450 and drug hydroxylation by liver microsomes of rats under physiologically abnormal states. (1969) (5)
- Decrease in the Metabolic Activating Capacities of Arylamines in Livers Bearing Hyperplastic Nodules: Association with the Selective Changes in Hepatic P‐450 Isozymes (1990) (5)
- Sulfotransferase- and acetyltransferase-mediated activation of carcinogenic N-hydroxyarylamines in mammals and bacteria, and their modulation by thiols. (1993) (5)
- Reduced nicotinamide adenine dinucleotide-dependent reduction of tertiary amine N-oxide by liver microsomal cytochrome P-450. (1977) (4)
- Inhibitory effect of TMK688 on skin tumor initiation caused by 7,12-dimethylbenz[a]anthracene in relation to inhibition of aryl hydrocarbon hydroxylase activity and Cyp1a1 mRNA induction. (1996) (4)
- Enhancement by alloxan-induced diabetes of the rate of metabolic activation of three pyrolysate carcinogens via increase in the P-448-H content in rat liver. (1988) (4)
- STUDIES ON SEX-SPECIFIC FORMS OF CYTOCHROME P-450 IN MALE AND FEMALE RATS (1985) (4)
- Chapter 4 Sex-dependent Regulation of Cytochrome P-450 Expression (1990) (4)
- Purification and properties of cytochrome P-450 and NADPH-cytochrome c (P-450) reductase from human liver microsomes. (1979) (4)
- Effect of Food Additives and Colors on Microsomal Drug-metabolizing Enzymes of Rat Liver (1969) (4)
- Lack of inhibitory action of aflatoxin on the induction of drug-metabolizing activities of liver microsomes by phenobarbital. (1969) (4)
- CLONING, EXPRESSION, AND FUNCTIONAL CHARACTERIZATION OF RAT AND HUMAN PHENOL SULFOTRANSFERASES (1992) (4)
- Regulations of male-dominant P-450Md mRNA in rat liver by hormonal factors and xenobiotics. (1991) (3)
- Purification, properties and function of N-hydroxyarylamine O-acetyltransferase. (1986) (3)
- Activation of Carcinogenic Compounds by Purified Cytochrome P-450 in Reconstituted Systems (1985) (3)
- Activities of NADPH-linked electron transport system in tumor-bearing rats. (1968) (3)
- Contrastic effects of ethionine and carbontetrachloride on ascorbic acid metabolism and on the activity of microsomal drug-metabolizing enzymes in rats. (1967) (3)
- Species difference in the inhibition of drug metabolism in liver microsomes by SKF 525A. (1966) (3)
- Acetyltransferase and sulfotransferase which activate mutagens and carcinogens through O-esterification mechanisms. (1990) (2)
- A gene structure of testosterone 6 beta-hydroxylase (P450IIIA). (1991) (2)
- High spin cytochrome P-448 with high activity for mutagenic activation of aromatic amines. (1983) (2)
- Pharmacogenetics and polymorphism of human P-450 which activates and detoxicates xenobiotics and carcinogens. (1990) (2)
- Influence of acetaldehyde and ethanol on rat hepatic lipocyte characteristics in primary culture (1995) (2)
- MECHANISMS OF METABOLIC ACTIVATION OF A TRYPTOPHAN PYROLYSATE, 3-AMINO-1-METHYL-5H-PYRIDO [4,3-b] INDOLE (1981) (1)
- N-Nitrosodialkylamine dealkylation in reconstituted systems containing cytochrome P-450 purified from phenobarbitaland β-naphthoflavone-treated rats (2006) (1)
- Acetyl-CoA dependent O-acetylation of N-hydroxyarylamines in bacterial and mammalian cells--the significance for mutagenesis and carcinogenesis. (1986) (1)
- Metabolism of mutagenic amino-gamma-carbolines in tryptophan pyrolysates. (1981) (1)
- Primary structure and regulation of hepatic sulfotransferases (1992) (1)
- STUDIES ON CYTOCHROME P-450 RESPONSIBLE FOR THE OCCURRENCE OF SEX DIFFERENCE OF DRUG METABOLISM IN THE RAT (1982) (1)
- Hepatic level of mRNA in relation to polymorphism and strain difference in expression of cytochrome P-450g. (1989) (1)
- Formation of Tertiary Amine N-Oxide and Its Reduction by Rat Liver Microsomes (1977) (1)
- Effect of stress on formation of stomach tumor in rats by N-methyl-N'-nitro-N-nitrosoguanidine. (1970) (1)
- Lack of chronic morphine effect on the induction of drug-metabolizing enzymes of liver microsomes by phenobarbital in female rats. (1967) (1)
- Species difference in drug metabolism by liver microsomes in alloxan diabetic or fasted animals. II. The substrate interaction with cytochrome P-450 in drug oxidation. (1970) (1)
- Sex related difference in cytochrome p 450 (1987) (1)
- Elimination, tissue accumulation, and metabolic fate of 4-nitroquinoline 1-oxide administered orally in rats. (1970) (1)
- MACROMOLECULAR BINDING OF CARCINOGENIC/MUTAGENIC N- HYDROXYARYLAMINES THROUGH O-ACETYLATION PATHWAY (1986) (0)
- Proceedings: N-ethanol oxidation of tiaramide by alcohol dehydrogenase. (1974) (0)
- Molecular characterization of mammalian Aryl(phenol) sulfotransferases (1993) (0)
- S-5 CURRENT TOPICS OF SPECIES SPECIFICITY IN DRUG TOXICITY-METABOLIC ASPECT (1989) (0)
- Sex difference in alteration of steroid delta4-hydrogenase activity in liver microsomes from rats bearing Walker carcinosarcoma-256. (1970) (0)
- B24 DRUG-INDUCED LOSS OF CONSTITUTIVE CYTOCHROME P-450 IN RAT LIVERS AND THE MECHANISM (1988) (0)
- STUDIES ON THE METABOLIC ACTIVATION AND THE MECHANISM OF TOXICITY OF DRUGS V. REDUCTION OF N-HYDROXY DERIVATIVE OF AN AROMATIC AMINE, 2-ACETYLAMINOFLUORENE BY CYTOCHROME P-450 (The 6th Meeting for the Study of Toxic Effect) (1979) (0)
- 1027 – REDUCTION OF TERTIARY AMINE N-OXIDE BY HEPATIC CYTOCHROME P-450 (1977) (0)
- Species Difference in M-Hydroxylation of a Tryptophan Pyrolysis Product in Relation to Mutagenic Activation 1 (2006) (0)
- [Carcinogens and their mechanism of action]. (1986) (0)
- Kato R & Gillette J R. Effect of starvation on NADPH-dependent enzymes in liver microsomes of male and female rats. J. Pharmacol. Exp. Ther. 150:279-84, 1965 (2004) (0)
- Introduction of Syrian hamster acetyltransferase gene into Salmonella typhimurium (1992) (0)
- MECHANISMS INVOLVED IN THE COVALENT BINDING OF A TRYPTOPHAN-PYROLYSATE PROMUTAGEN, TRP-P-2,TO DNA (1983) (0)
- Oral Presentations – Skin Pharmacology Society, 7th Annual Meeting, October 30–31, 1990, Japan (1990) (0)
- STEREOSELECTIVE HYDROXYLATION OF MEPHENYTOIN IN HUMAN LIVERS : CLONING AND EXPRESSION OF MEPHENYTOIN HYDROXYLASE cDNAS IN YEASTS AND THE GENETIC POLYMORPHISM (1991) (0)
- DEGRADATION OF CYTOCHROME P-450 ASSOCIATED WITH METABOLIC ACTIVATION OF CARBON TETRACHLORIDE (The 5th Meeting for the Study of Toxic Effect) (1978) (0)
- REDUCTION OF A TERTIARY AMINE N-OXIDE AND AN ARENE OXIDE IN RELATION TO THE REDUCTION RATE OF CYTOCHROME P-450 IN RAT LIVER MICROSOMES (1977) (0)
- PURIFICATION AND PROPERTIES OF CYTOCHROME P-450 AND NADPH-CYTOCHROME C (P-450) REDUCTASE FROM MICROSOMES OF HUMAN LIVERS (1980) (0)
- Polymorphism of Acetyltransferase in Hamster Liver: Isolation and Expression of cDNA and Genomic DNA in Cells of Different Species (1993) (0)
- Posters – Skin Pharmacology Society, 7th Annual Meeting, October 30–31, 1990, Japan (1990) (0)
- 326 A USEFUL MEASURE OF HEPATIC DRUG-OXIDIZING CAPACITY : CAFFEINE AND TRIMETHADIONE ELIMINATION AS THE INDICATORS (1992) (0)
- MULTIPLICITY AND EXPRESSIN OF RAT CYP3A (1994) (0)
- 335 – THE REDUCTION OF POLYCYCLIC AROMATIC HYDROCARBON EPOXIDES BY CYTOCHROME P-448 (1978) (0)
- Detection of Drosophila P-450s using anti-rat P-450 antibodies (1988) (0)
- Decreases in the metabolic activating capacities of arylamines in preneoplastic state: association with selective changes in hepatic P-450 isozymes (1991) (0)
- AN UNUSUAL METABOLITE OF TESTOSTERONE BY CYTOCHROME P-450 (1987) (0)
- ROLE OF GROWTH HORMONE ON THE EXPRESSION OF SEX-SPECIFIC FORMS OF CYTOCHROME P-450,P-450-MALE AND P-450-FEMALE (1987) (0)
- TOXICOLOGICAL SIGNIFICANCE OF A FORM OF CYTOCHROME P-450 HIGHLY PURIFIED FROM LIVER MICROSOMES OF PCBTREATED RATS : CATALYTIC AND IMMUNOCHEMICAL EXAMINATIONS OF A HIGH SPIN FORM OF CYTOCHROME P-448 (1984) (0)
- Effects of dicarboxylic acids on fatty acid-metabolizing enzymes in cultured rat hepatocytes. (1995) (0)
- Species difference in drug metabolism by liver microsomes in alloxan diabetic or fasted animals. I. The activity of drug-metabolizing enzymes and electron transport system. (1970) (0)
- Studies on sex-related difference of cytochrome P-450 in rat liver microsomes (IV). Radial immunodiffusion assay and regulation by sex hormones of forms of cytochrome P-450 present specifically in males and females, respectively (1983) (0)
- Metabolismand Activationof Aflatoxin B1by ReconstitutedCytochrome P-450 System of Rat Liver1 (2006) (0)
- Rat liver sulfotransferase activating carcinogenic hydroxymethyl-arenes : its properties and sequence analysis of cDNA (1990) (0)
- The Role of Glutathione in the Activation and Detoxication of a Naturally Occurring Mutagen-Carcinogen, Trp-P-2 (Regular Presentations) (Proceedings of the 10 th Symposium on Environmental Pollutants and Toxicology) (1984) (0)
- Thyroid hormone-mediated regulation of hepatic cytochrome P-450 (1990) (0)
- Polymorphism in stereoselective hydroxylation of hexobarbital isomers in relation to P-450 human-2 (mephenytoin hydroxylase) (1990) (0)
- A SENSITIVE METHOD FOR THE DETERMINATION OF BIPHENYL HYDROXYLASE ACTIVITY AND IT'S TOXICOLOGICAL APPLICATION (1981) (0)
- REGULATION AND CHARACTERIZATION OF STEROID 6β-HYDROXYLASE IN RAT LIVERS (1989) (0)
- Mechanism of the changes in hepatic drug metabolizing enzymes in diabetic states (1990) (0)
- [Symposium--drug metabolism and drug action. 5. Sex difference in drug effects and drug metabolizing enzyme activity in the rat liver microsomes--normal and chemically and physiologically altered states]. (1970) (0)
- 346 – PROPERTIES OF CYTOCHROME P-450 PARTIALLY PURIFIED FROM HUMAN LIVER MICROSOMES (1978) (0)
- Metabolic activation and mechanism of drug toxicity: VIII. Metabolic activation of Trp-P-2, a mutagenic aromatic amine from tryptophan-pyrolysates. (1980) (0)
- Cloning and expression of hamster arylamine acetyltransferase cDNA (1991) (0)
- Effects of Hypophysectomy and Growth Hormone Treatment on Sex-Specific Forms of Cytochrome P-450 in Relation to Drug and Steroid Metabolisms in Rat Liver Microsomest (2006) (0)
- Expression and Functional Characterization of a Rat Sulfotransferase (ST1A1) cDNA for Sulfations of Phenolic Substrates in COS-1 Cells•õ (2006) (0)
- Substrate interaction with P-450 in the hydroxylation of drugs under abnormal physiological states. (1971) (0)
- [Problems of species specificity in toxicity evaluation. 5. Species specificity in pharmacokinetics]. (1989) (0)
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