R. Michael Blaese
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Philosophy
R. Michael Blaese's Degrees
- PhD Microbiology University of Washington
- Bachelors Biology University of California, San Diego
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(Suggest an Edit or Addition)R. Michael Blaese's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. (1992) (1569)
- T Lymphocyte-Directed Gene Therapy for ADA− SCID: Initial Trial Results After 4 Years (1995) (1412)
- Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells (1997) (696)
- Role of suppressor T cells in pathogenesis of common variable hypogammaglobulinaemia. (1974) (633)
- A multiinstitutional survey of the Wiskott-Aldrich syndrome. (1994) (597)
- Engraftment of gene–modified umbilical cord blood cells in neonates with adenosine deaminase deficiency (1995) (594)
- Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: a negative selection system. (1992) (526)
- In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats. (1993) (474)
- Gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir. (1993) (417)
- Improved methods of retroviral vector transduction and production for gene therapy. (1994) (401)
- T lymphocytes with a normal ADA gene accumulate after transplantation of transduced autologous umbilical cord blood CD34+ cells in ADA-deficient SCID neonates (1998) (325)
- Immune response to B19 parvovirus and an antibody defect in persistent viral infection. (1989) (318)
- High-efficiency retroviral-mediated gene transfer into human and nonhuman primate peripheral blood lymphocytes. (1995) (266)
- Wiskott-Aldrich syndrome/X-linked thrombocytopenia: WASP gene mutations, protein expression, and phenotype. (1997) (266)
- Tumors expressing the cytosine deaminase suicide gene can be eliminated in vivo with 5-fluorocytosine and induce protective immunity to wild type tumor. (1994) (247)
- Gene therapy for adenosine deaminase-deficient severe combined immune deficiency: clinical comparison of retroviral vectors and treatment plans. (2012) (229)
- Disorders of suppressor immunoregulatory cells in the pathogenesis of immunodeficiency and autoimmunity. (1978) (222)
- Defective EBV-specific suppressor T-cell function in rheumatoid arthritis. (1981) (215)
- Long-term in vivo survival of receptor-modified syngeneic T cells in patients with human immunodeficiency virus infection. (2000) (214)
- Acyclovir treatment of the chronic fatigue syndrome. Lack of efficacy in a placebo-controlled trial. (1988) (211)
- The Wiskott-Aldrich syndrome and X-linked congenital thrombocytopenia are caused by mutations of the same gene. (1995) (209)
- Persistence and expression of the adenosine deaminase gene for 12 years and immune reaction to gene transfer components: long-term results of the first clinical gene therapy trial. (2003) (205)
- Immunodeficiency disease and malignancy. Various immunologic deficiencies of man and the role of immune processes in the control of malignant disease. (1972) (204)
- The ADA human gene therapy clinical protocol: Points to Consider response with clinical protocol, July 6, 1990. (1990) (202)
- Gene therapy of cancer. (1994) (194)
- Therapy of colon cancer with oncolytic adenovirus is enhanced by the addition of herpes simplex virus-thymidine kinase. (1999) (190)
- Abnormally elevated frequency of Epstein-Barr virus-infected B cells in the blood of patients with rheumatoid arthritis. (1984) (184)
- Adenoviral vectors capable of replication improve the efficacy of HSVtk/GCV suicide gene therapy of cancer (1999) (180)
- The effect of thymidine kinase transduction and ganciclovir therapy on tumor vasculature and growth of 9L gliomas in rats. (1994) (173)
- The Wiskott-Aldrich syndrome. A disorder with a possible defect in antigen processing or recognition. (1968) (172)
- X-linked hypogammaglobulinemia and isolated growth hormone deficiency. (1980) (170)
- Immune response to fetal calf serum by two adenosine deaminase-deficient patients after T cell gene therapy. (2002) (169)
- Amphotropic murine leukemia retrovirus is not an acute pathogen for primates. (1990) (160)
- Increased immunoglobulin-secreting cells in the blood of patients with active systemic lupus erythematosus. (1980) (159)
- The effector cells in human peripheral blood mediating mitogen-induced cellular cytotoxicity and antibody-dependent cellular cytotoxicity. (1976) (152)
- Successful peripheral T-lymphocyte-directed gene transfer for a patient with severe combined immune deficiency caused by adenosine deaminase deficiency. (1998) (149)
- Polyclonal immunoglobulin secretion by human B lymphocytes exposed to Epstein-Barr virus in vitro. (1979) (148)
- Human gene transfer: characterization of human tumor-infiltrating lymphocytes as vehicles for retroviral-mediated gene transfer in man. (1990) (147)
- Structural and functional basis for JAK3-deficient severe combined immunodeficiency. (1997) (146)
- Endonuclease analysis of viral DNA from varicella and subsequent zoster infections in the same patient. (1984) (139)
- Signaling via IL-2 and IL-4 in JAK3-deficient severe combined immunodeficiency lymphocytes: JAK3-dependent and independent pathways. (1996) (139)
- Lymphocytes as cellular vehicles for gene therapy in mouse and man. (1991) (136)
- Recommendations for live viral and bacterial vaccines in immunodeficient patients and their close contacts. (2014) (136)
- Splenectomy in the management of the thrombocytopenia of the Wiskott-Aldrich syndrome. (1980) (135)
- Mechanism of ‘bystander effect’ killing in the herpes simplex thymidine kinase gene therapy model of cancer treatment (1997) (134)
- Epstein-Barr virus infection and immunoregulation in man. (1985) (133)
- Defective lymphocyte transformation and delayed hypersensitivity in Wiskott-Aldrich syndrome. (1970) (131)
- Lymphocyte gene therapy. (1991) (130)
- Infection efficiency of T lymphocytes with amphotropic retroviral vectors is cell cycle dependent (1989) (128)
- The release of inflammatory cytokines from human peripheral blood mononuclear cells in vitro following exposure to adenovirus variants and capsid. (2002) (127)
- Peripheral expansion of pre-existing mature T cells is an important means of CD4+ T-cell regeneration HIV-infected adults (1998) (125)
- A receptor for IgA on human T lymphocytes. (1979) (122)
- Characterization of common variable immunodeficiency: identification of a subset of patients with distinctive immunophenotypic and clinical features. (1990) (118)
- Fibrosarcoma cells transduced with the IL-6 gene exhibited reduced tumorigenicity, increased immunogenicity, and decreased metastatic potential. (1992) (115)
- Isolation of papovavirus from brain tumor and urine of a patient with Wiskott-Aldrich syndrome. (1974) (114)
- Characteristic T cell dysfunction in patients with chronic active Epstein-Barr virus infection (chronic infectious mononucleosis). (1985) (111)
- B cell differentiation and immunoregulatory T cell function in human cord blood lymphocytes. (1980) (110)
- Enhancement of the herpes simplex virus thymidine kinase/ganciclovir bystander effect and its antitumor efficacy in vivo by pharmacologic manipulation of gap junctions. (1998) (109)
- Toxicity studies of retroviral-mediated gene transfer for the treatment of brain tumors. (1993) (107)
- The bystander effect in the HSVtk/ganciclovir system and its relationship to gap junctional communication (1998) (106)
- INFECTIOUS AGAMMAGLOBULINEMIA: TRANSMISSION OF IMMUNODEFICIENCY WITH GRAFTS OF AGAMMAGLOBULINEMIC CELLS (1974) (106)
- Monocyte-mediated antibody-dependent cellular cytotoxicity: a clinical test of monocyte function. (1976) (104)
- Identification of mutations in the Wiskott-Aldrich syndrome gene and characterization of a polymorphic dinucleotide repeat at DXS6940, adjacent to the disease gene. (1995) (101)
- Limiting dilution analysis of Epstein-Barr virus-induced immunoglobulin production by human B cells (1983) (101)
- Hypercatabolism of IgG, IgA, IgM, and albumin in the Wiskott-Aldrich syndrome. A unique disorder of serum protein metabolism. (1971) (100)
- Splenectomy and/or bone marrow transplantation in the management of the Wiskott-Aldrich syndrome: long-term follow-up of 62 cases. (1993) (99)
- Relationship between immunoglobulin production and immortalization by Epstein Barr virus. (1985) (99)
- Immunoglobulin production induced in vitro by glucocorticoid hormones: T cell-dependent stimulation of immunoglobulin production without B cell proliferation in cultures of human peripheral blood lymphocytes. (1981) (98)
- In vivo transfer of the human interleukin-2 gene: negative tumoricidal results in experimental brain tumors. (1994) (96)
- Malignant lymphoma in patients with the Wiskott-Aldrich syndrome. (1985) (90)
- Splenectomy and/or bone marrow transplantation in the management of the Wiskott-Aldrich syndrome: long-term follow-up of 62 cases (1993) (87)
- Immunoglobulin secreting cells in normal human bronchial lavage fluids. (1978) (87)
- Abnormalities of chemotactic lymphokine synthesis and mononuclear leukocyte chemotaxis in Wiskott-Aldrich syndrome. (1974) (87)
- Defective mononuclear leukocyte chemotaxis: a previously unrecognized immune dysfunction. Studies in a patient with chronic mucocutaneous candidiasis. (1973) (85)
- IMMUNODEFICIENCY IN FAMILIAL ERYTHROPHAGOCYTIC LYMPHOHISTIOCYTOSIS (1978) (83)
- Platelet-associated immunoglobulin, platelet size, and the effect of splenectomy in the Wiskott-Aldrich syndrome. (1985) (83)
- Development of Gene Therapy for Immunodeficiency: Adenosine Deaminase Deficiency (1993) (81)
- Carrier detection in the Wiskott Aldrich syndrome (1988) (80)
- Impaired lymphocyte transformation in intestinal lymphangiectasia: evidence for at least two functionally distinct lymphocyte populations in man. (1972) (75)
- Retroviral-mediated gene correction for X-linked severe combined immunodeficiency. (1996) (73)
- Human gene marker/therapy clinical protocols. (1996) (73)
- Suppression of the human autologous mixed lymphocyte reaction by physiologic concentrations of hydrocortisone. (1977) (70)
- Preferential survival of CD4+ T lymphocytes engineered with anti-human immunodeficiency virus (HIV) genes in HIV-infected individuals. (2005) (69)
- In vitro correction of JAK3-deficient severe combined immunodeficiency by retroviral-mediated gene transduction (1996) (69)
- Selective inhibition of immunoregulatory cell functions by cyclosporin A. (1982) (67)
- Acyclovir treatment of the chronic fatigue syndrome. (1988) (66)
- Correction of ADA deficiency in human T lymphocytes using retroviral-mediated gene transfer. (1991) (66)
- Soluble suppressor supernatants elaborated by concanavalin A-activated human mononuclear cells. II. Characterization of a soluble suppressor of B cell immunoglobulin production. (1981) (65)
- A simple and reliable method for screening retroviral producer clones without selectable markers. (1997) (63)
- Phytohemagglutinin as a skin test for the evaluation of cellular immune competence in man. (1973) (60)
- Development of Improved Adenosine Deaminase Retroviral Vectors (1998) (59)
- IMMUNOLOGIC INCOMPETENCE OF IMMUNOLOGICALLY RUNTED ANIMALS. (1964) (59)
- T cell-mediated immunoregulation of Epstein Barr virus- (EBV) induced B lymphocyte activation in EBV-seropositive and EBV-seronegative individuals. (1982) (58)
- Gene therapy for cancer. (1997) (57)
- Intrathecal gene therapy for malignant leptomeningeal neoplasia. (1994) (57)
- Ontogeny of humoral immune function in normal chickens: a comparison of immunoglobulin-secreting cells in bone marrow, spleen, lungs and intestine. (1981) (54)
- Induction of an antitumor immunological response by an intratumoral injection of dendritic cells pulsed with genetically engineered Semliki Forest virus to produce interleukin-18 combined with the systemic administration of interleukin-12. (2003) (52)
- Infection of human cells with murine amphotropic replication-competent retroviruses. (1993) (51)
- Evidence that specific oligosaccharides block early events necessary for the expression of antigen-specific proliferation by human lymphocytes. (1980) (51)
- Human gene marker/therapy clinical protocols. (1999) (51)
- Molecular analysis of T lymphocyte-directed gene therapy for adenosine deaminase deficiency: long-term expression in vivo of genes introduced with a retroviral vector. (1996) (51)
- Granulocyte colony-stimulating factor recruitment of CD34+ progenitors to peripheral blood : Impaired mobilization in chronic granulomatous disease and adenosine deaminase-deficient severe combined immunodeficiency disease patients (1996) (51)
- In vivo expression and survival of gene-modified T lymphocytes in rhesus monkeys. (1990) (50)
- Increased bronchoalveolar IgG-secreting cells in interstitial lung diseases. (1980) (50)
- The origin of salivary IgA. (1970) (49)
- Retrovirus-mediated WASP gene transfer corrects defective actin polymerization in B cell lines from Wiskott–Aldrich syndrome patients carrying ‘null’ mutations (1999) (47)
- Immunoregulatory properties of fractions from human pregnancy urine: evidence that human chorionic gonadotropin is not responsible. (1977) (45)
- Scanning of the Wiskott-Aldrich syndrome (WAS) gene: identification of 18 novel alterations including a possible mutation hotspot at Arg86 resulting in thrombocytopenia, a mild WAS phenotype. (1995) (45)
- Adeno-retroviral chimeric viruses as in vivo transducing agents (1999) (44)
- Constrictive pericarditis, intestinal lymphangiectasia, and reversible immunologic deficiency. (1975) (43)
- Familial chronic lymphocytic leukemia. Immunologic and cellular characterization. (1976) (43)
- Variable immunodeficiency with abnormal condensation of the heterochromatin of chromosomes 1, 9, and 16. (1988) (43)
- Retroviral transfer of acid alpha-glucosidase cDNA to enzyme-deficient myoblasts results in phenotypic spread of the genotypic correction by both secretion and fusion. (1997) (42)
- Enzyme prodrug gene therapy: synergistic use of the herpes simplex virus-cellular thymidine kinase/ganciclovir system and thymidylate synthase inhibitors for the treatment of colon cancer. (1999) (42)
- Fc receptors for IgA on human B, and human non-B, non-T lymphocytes. (1979) (41)
- Characterization of the antitumor immune response generated by treatment of murine tumors with recombinant adenoviruses expressing HSVtk, IL-2, IL-6 or B7-1 (1997) (40)
- A reappraisal of the effector cells mediating mitogen induced cellular cytotoxicity. (1975) (40)
- Carrier detection in the Wiskott Aldrich syndrome. (1988) (39)
- Immunodeficiency in the Wiskott-Aldrich syndrome. (1975) (39)
- Somatic mosaicism in the Wiskott-Aldrich syndrome: molecular and functional characterization of genotypic revertants. (2010) (39)
- Efficient directional cloning of recombinant adenovirus vectors using DNA-protein complex. (1998) (38)
- Reconstitution of normal megakaryocytopoiesis and immunologic functions in Wiskott-Aldrich syndrome by marrow transplantation following myeloablation and immunosuppression with busulfan and cyclophosphamide. (1981) (38)
- Establishment and characterization of adenosine deaminase-deficient human T cell lines. (1989) (37)
- Artifactual plaque formation in vitro and in vivo to passive transfer of specific antibody. (1976) (37)
- Long-term remission from acute myelogenous leukemia after bone marrow transplantation and recovery from acute graft-versus-host reaction and prolonged immunoincompetence. (1975) (37)
- Defibrination syndrome in an infantborn after abruptio placentae (1968) (36)
- Lymphocyte-macrophage interaction in antigen induced in vitro lymphocyte transformation in patients with the Wiskott-Aldrich syndrome and other diseases with anergy. (1972) (36)
- Antibodies to nucleic acids in congenital immune deficiency states. (1976) (36)
- Cooperative interaction of factor B and other complement components with mononuclear cells in the antibody-independent lysis of xenogeneic erythrocytes (1982) (35)
- Functional properties of human T cells bearing Fc receptors for IgA. I. Mitogen responsiveness, mixed lymphocyte culture reactivity, and helper activity for B cell immunoglobulin production. (1980) (35)
- Treatment of severe combined immunodeficiency disease (SCID) due to adenosine deaminase deficiency with CD34+ selected autologous peripheral blood cells transduced with a human ADA gene. Amendment to clinical research project, Project 90-C-195, January 10, 1992. (1993) (35)
- Granulocyte colony-stimulating factor recruitment of CD34+ progenitors to peripheral blood: impaired mobilization in chronic granulomatous disease and adenosine deaminase--deficient severe combined immunodeficiency disease patients. (1996) (35)
- Keratinocyte gene therapy for adenosine deaminase deficiency: a model approach for inherited metabolic disorders. (1997) (34)
- Synergy between the herpes simplex virus tk/ganciclovir prodrug suicide system and the topoisomerase I inhibitor topotecan. (1999) (34)
- Normalization of antibody responsiveness in a patient with common variable hypogammaglobulinemia and HIV infection. (1987) (34)
- In situ delivery of suicide genes for cancer treatment. (1994) (34)
- POKEWEED MITOGEN-, CONCANAVALIN A-, AND PHYTOHEMAGGLUTININ-INDUCED DEVELOPMENT OF CYTOTOXIC EFFECTOR LYMPHOCYTES (1973) (33)
- A phase I study of intralesional administration of an adenovirus vector expressing the HSV-1 thymidine kinase gene (AdV.RSV-TK) in combination with escalating doses of ganciclovir in patients with cutaneous metastatic malignant melanoma. (2000) (33)
- Spontaneous cytotoxicity of human peripheral mononuclear cells toward red blood cell targets in vitro. I. characterization of the killer cell. (1977) (33)
- Hereditary thrombocytopenia: relation to Wiskott-Aldrich syndrome with special reference to splenectomy. Report of a family and review of the literature. (1972) (33)
- Pure red blood cell aplasia associated with chronic Epstein-Barr virus infection: evidence for T cell-mediated suppression of erythroid colony forming units. (1984) (32)
- Gene Therapy for Severe Combined Immunodeficiency Caused by Adenosine Deaminase Deficiency: Improved Retroviral Vectors for Clinical Trials (1999) (31)
- Newborn and Wiskott-Aldrich patient B cells can be activated by TNP-Brucella abortus: evidence that TNP-Brucella abortus behaves as a T-independent type 1 antigen in humans. (1984) (31)
- The Wiskott-Aldrich syndrome protein (1996) (30)
- Development of a skin-based metabolic sink for phenylalanine by overexpression of phenylalanine hydroxylase and GTP cyclohydrolase in primary human keratinocytes (2000) (30)
- Patients with Wiskott-Aldrich syndrome have normal IgG2 levels. (1986) (30)
- Interferon-mediated inhibition of human polyclonal immunoglobulin synthesis. (1982) (28)
- Intrathecal Gene Therapy for the Treatment of Leptomeningeal Carcinomatosis. National Institutes of Health, Bethesda, Maryland (1995) (28)
- Adenovirus vectors as transcomplementing templates for the production of replication defective retroviral vectors. (1998) (28)
- Hereditary sensory neuropathy. Association with increased synthesis of immunoglobulin A. (1974) (27)
- Monoclonal gammopathy in the Wiskott-Aldrich syndrome. (1974) (26)
- T cell-replacing factor for glucocorticosteroid-induced immunoglobulin production. A unique steroid-dependent cytokine (1983) (26)
- Retrovirus-mediated gene transfer of ornithine-delta-aminotransferase into keratinocytes from gyrate atrophy patients. (1997) (24)
- Retroviral expression of recombinant p47phox protein by Epstein-Barr virus-transformed B lymphocytes from a patient with autosomal chronic granulomatous disease. (1992) (24)
- IMMUNOLOGIC INCOMPETENCE OF IMMUNOLOGICALLY RUNTED ANIMALS (1964) (24)
- Strategies for gene therapy. (1993) (24)
- Suppressor T cell clones from patients with acute Epstein-Barr virus-induced infectious mononucleosis. (1987) (24)
- A study of the safety and survival of the adoptive transfer of genetically marked syngeneic lymphocytes in HIV-infected identical twins. (1993) (23)
- Spontaneous cytotoxicity of human peripheral blood mononuclear cells toward red blood cell targets. II. Time-dependent loss of suppressor cell activity. (1977) (23)
- Toxicity studies and distribution dynamics of retroviral vectors following intrathecal administration of retroviral vector-producer cells. (1995) (22)
- Progress toward gene therapy. (1991) (22)
- Purification and characterization of a mannose-containing disaccharide obtained from human pregnancy urine. A new immunoregulatory saccharide (1984) (22)
- Tissue distribution of immunoglobulin-secreting cells in normal and IgA-deficient chickens. (1979) (22)
- Induction of cytotoxic effector activity in the HL-60 promyelocytic cell line by incubation with phorbol myristate acetate: a model system of human spontaneous monocyte-mediated cytotoxicity. (1983) (21)
- Immunologic deficiency diseases. (1971) (21)
- Characterization of a soluble suppressor of human B cell immunoglobulin biosynthesis produced by a continuous human suppressor T cell line (1981) (21)
- Increased sensitivity of lymphocyte Δ1pyrroline-5-carboxylate reductase to inhibition by proline with transformation (1975) (21)
- Gene therapy for primary immunodeficiency disease. (1992) (20)
- Cytotoxic effector cell function in organized gut-associated lymphoid tissue (GALT). (1976) (19)
- Reversal of infectious mononucleosis-associated suppressor T cell activity by D-mannose (1983) (19)
- Infectious agammaglobulinemia: suppressor T cells with specificity for individual immunoglobulin classes. (1977) (18)
- The cytotoxic effector potential of some common non-lymphoid tumors and cultured cell lines with phytohemagglutinin and heterologous anti-erythrocyte antisera. (1975) (18)
- Gene therapy: lessons learnt from the past decade (1999) (18)
- Spontaneous cytotoxicity by human peripheral blood monocytes: inhibition by monosaccharides and oligosaccharides. (1981) (17)
- Gene transfer and expression in nonhuman primates using retroviral vectors. (1986) (17)
- TNF/TIL Human Gene Therapy Clinical Protocol: Original Protocol, April 23, 1990 (1990) (16)
- Production of macrophage migration inhibitory factor and lymphotoxin by leukocytes from normal and Wiskott-Aldrich syndrome patients. (1973) (16)
- The effect of Mycobacterium bovis (Bacillus Calmette-Guérin) on macrophage random migration, chemotaxis, and pinocytosis. (1976) (16)
- The mononuclear phagocyte system: role in expression of immunocompetence in neonatal and adult life. (1979) (16)
- Generation of a conditionally neor-containing retroviral producer cell line: effects of neor on retroviral titer and transgene expression (1998) (15)
- A high-resolution map of genes, microsatellite markers, and new dinucleotide repeats from UBE1 to the GATA locus in the region Xp11.23. (1995) (15)
- Inhibition of antigen-stimulated in vitro proliferation of thymic dependent chicken spleen cells by specific antibody. (1972) (15)
- Immunostimulation by cytomegalovirus (CMV): helper T cell-dependent activation of immunoglobulin production in vitro by lymphocytes from CMV-immune donors. (1985) (14)
- Inhibition of human lymphoproliferation by intravenous lipid emulsion. (1982) (14)
- Ophthalmic manifestations of the Wiskott-Aldrich syndrome. (1969) (14)
- Malignant lymphoma of the jejunum in a patient with Wiskott-Aldrich syndrome. Surgical treatment. (1975) (14)
- A novel approach using transcomplementing adenoviral vectors for gene therapy of adrenocortical cancer. (2002) (14)
- EVIDENCE THAT MONOCYTE MEDIATED CELLULAR RECOGNITION PHENOMENA ARE MEDIATED BY RECEPTORS WITH SPECIFICITY FOR SIMPLE OLIGOSACCHARIDES (1980) (14)
- Effects of IMP dehydrogenase inhibitors on the phosphorylation of ganciclovir in MOLT-4 cells before and after herpes simplex virus thymidine kinase gene transduction. (1994) (13)
- Synergistic cytotoxicity. I. Characterization of a heat labile plasma fraction that induces nonspecific cytotoxicity by human mononuclear cells. (1979) (13)
- IMMUNODEFICIENCY IN FAMILIAL ERYTHROPHAGOCYTIC LYMPHOHISTIOCYTOSIS (1978) (12)
- Immunosuppressive activity of succinylacetone. (1982) (12)
- Effect of Corynebacterium parvum, methanol-extraction residue of BCG, and levamisole on macrophage random migration, chemotaxis, and pinocytosis. (1977) (12)
- Defibrination syndrome in an infant born after abruptio placentae. (1968) (12)
- Use of a herpes thymidine kinase/neomycin phosphotransferase chimeric gene for metabolic suicide gene transfer (2000) (12)
- MICC cytotoxic effector function of human T lymphocyte subpopulations bearing Fc-receptors for IgG and IgM. (1979) (12)
- Biosynthetic ganciclovir triphosphate: its isolation and characterization from ganciclovir-treated herpes simplex thymidine kinase-transduced murine cells. (2001) (11)
- Intrathecal gene therapy for the treatment of leptomeningeal carcinomatosis. GTI 0108. A phase I/II study. (1995) (11)
- Uromodulin: a specific inhibitor of IL-1-initiated human T cell colony formation. (1990) (11)
- Enhanced cAMP production by activated human Fc-IgG receptor positive T-cell subpopulations. (1981) (11)
- Hemolytic anemia in agammaglobulinemic chickens: a model of "autoimmune" disease in immune deficiency. (1971) (10)
- Spontaneous cytotoxicity. III. Inhibition of human monocyte mediated cytotoxicity by pokeweed mitogen. (1979) (10)
- Synergistic cytotoxicity. II. In vitro arming of monocytes and T cells by a heat labile fraction of human plasma. (1979) (10)
- 17 – PHYSIOLOGICAL FACTORS CONTROLLING IMMUNOGLOBULIN METABOLISM (1970) (10)
- Lack of effector cell function in chronic lymphocytic leukemia, a B-cell malignancy, and the Sézary syndrome, a T-cell malignancy. (1978) (10)
- Reconstitution of immunologic function in a patient with severe combined immunodeficiency following transplantation of marrow from an HLA-A,B,C nonidentical but MLC-compatible paternal donor. (1979) (9)
- Anti-tumor immunity generated by tumor cells engineered to express B7-1 via retroviral or adenoviral gene transfer. (1998) (9)
- Gene Therapy for Adenosine Deaminase Deficiency and Malignant Solid Tumors (1994) (9)
- Human gene marker/therapy clinical protocols. (1997) (9)
- The treatment of adenosine deaminase deficiency. (1987) (9)
- What is the status of gene therapy for primary immunodeficiency? (2007) (9)
- Suppressor T-cell function in man: suppression of immunoglobulin production by the direct action of immunoregulatory T cells on the B cell in four separate, distinct systems. (1982) (8)
- T3-T cell receptor (Ti) complex-independent activation of T cells by wheat germ agglutinin. (1987) (8)
- Lymphoid populations of gut mucosa in chickens (1980) (8)
- Immunosuppression by succinylacetone. II. Prevention of graft-vs-host disease. (1987) (8)
- WISKOTT-ALDRICH SYNDROME (WAS) CARRIER DETECTION BY X-CHROMOSOME INACTIVATION ANALYSIS (1987) (8)
- Immunization Of The Immunocompromised Host (1998) (7)
- Gene therapy for genetic diseases. (1989) (7)
- Immunoglobulin metabolism in disease. (1975) (7)
- The role of nonactivated and interferon-gamma activated monocytes in regulating normal and SLE patient B cell responses to TNP-Brucella abortus. (1986) (7)
- Steps toward gene therapy: 2. Cancer and AIDS. (1995) (7)
- Cellular distribution of a human I-A-like (DS/DC) antigen on normal and neoplastic lymphoid cells. (1985) (7)
- Steps toward gene therapy: 1. The initial trials. (1995) (7)
- Treatment of experimental autoimmune uveitis in the rat with systemic succinylacetone. (1988) (7)
- 18 Suicide Genes: Gene Therapy Applications Using Enzyme/Prodrug Strategies (1999) (6)
- Brain tumor treatment: significant contributions. (1992) (6)
- A CRITIQUE OF TECHNIQUES OF MACROPHAGE-MONOCYTE DEPLETION IN STUDIES OF HUMAN PERIPHERAL BLOOD MONONUCLEAR LEUKOCYTE (MNL) FUNCTION (1977) (6)
- Phytohaemagglutinin-induced cytotoxic effector lymphocyte function in patients with the Wiskott-Aldrich syndrome (WAS). (1973) (6)
- The role of cell surface lectin--carbohydrate interactions in cellular recognition, cooperation, and regulation. (1983) (6)
- Synergistic Cytotoxicity (1979) (6)
- Differential effects of ouabain on human cell-mediated cytotoxicity. I. Inhibition of mitogen-induced cellular cytotoxicity and antibody-dependent cellular cytotoxicity against chicken red cell targets. (1979) (6)
- Enumeration of pulmonary immunoglobulin secreting cells in human bronchoalveolar lavage. (1979) (6)
- Optimism regarding the use of RNA/DNA hybrids to repair genes at high efficiency (1999) (6)
- Retroviral-mediated gene transfer into hemopoietic cells. (1988) (5)
- Infection of human hematopoietic progenitor cells using a retroviral vector with a xenotropic pseudotype. (1988) (5)
- Monocyte cytotoxicity: evidence for multiple mechanisms of in vitro erythrocyte target killing. Trypan blue can both inhibit and enhance target lysis. (1982) (5)
- Seasonal viral influenza among persons with primary antibody immunodeficiency. (2019) (5)
- Retrovirus mediated gene transfer as therapy for adenosine deaminase (ADA) deficiency. (1995) (5)
- Evidence of two functionally distinct lymphocyte populations in man. (1973) (5)
- Retrovirus-mediated gene transfer into CD4+ and CD8+ human T cell subsets derived from tumor-infiltrating lymphocytes and peripheral blood mononuclear cells (1991) (5)
- Lymphokine induction of DR Antigen expression on human neonatal and cell line monocytes (1982) (5)
- Gene therapy for cancer. (1997) (5)
- 712 SPLENECTOMY AND PROPHYLACTIC ANTIBIOTICS IN THE MANAGEMENT OF THE WISKOTT-ALDRICH SYNDROME (WAS) (1978) (4)
- Macrophage function in the development of immunocompetence and in immunodeficiency. (1976) (4)
- Gene therapy of primary immunodeficiencies (2004) (4)
- THE USE OF GENE THERAPY FOR IMMUNODEFICIENCY DISEASE (1996) (3)
- CHAPTER 21 – IMMUNOGLOBULIN SECRETING CELLS IN THE CIRCULATING BLOOD AND IN MITOGEN STIMULATED CULTURES FROM PATIENTS WITH IMMUNODEFICIENCY DISEASES (1979) (3)
- Characterization of T cell ligands for uromodulin: a possible role in costimulation. (1994) (3)
- A MONOCLONAL ANTIBODY DIRECTED AGAINST A HUMAN B LYMPHOID CELL ACTIVATION ANTIGEN (1982) (3)
- Hepatitis B virus infection in the Wiskott-Aldrich syndrome. (1976) (3)
- Differential effects of ouabain on human cell-mediated cytotoxicity. II. Stimulation of monocyte-mediated, spontaneous cytotoxicity against chicken red cell targets. (1979) (3)
- 18 – ABNORMALITIES OF IMMUNOGLOBULIN METABOLISM (1970) (2)
- Defective allosuppression in patients with ataxia-telangiectasia. (1985) (2)
- Lymphoid cell-derived lectin-like receptor molecules as immunoregulatory signals in immunodeficiency. (1983) (2)
- Disorders of Suppressor T Cells in Immunodeficiency and Malignancy (1980) (2)
- thrombocytopenia are caused by mutations of the same gene The Wiskott-Aldrich syndrome and X-linked congenital (2011) (2)
- Inhibition of human lymphoproliferative responses and altered lymphocyte membrane phenotype by succinylacetone. (1992) (1)
- Immunodeficiency Disease and Malignancy (2020) (1)
- Challenges of Genetic Disease: Gene Addition or Gene Repair (1999) (1)
- Immune Assessment of Patients with Chronic Active EBV Infection (CAEBV) (1985) (1)
- The proportion of TA, TG, and TM cells in various immunodeficiency and autoimmune disorders. (1983) (1)
- Phytohemagglutinin (PHA) skin test: A measure of intact cellmediated immunity (1971) (1)
- Monoclonal gammopathy in syndrome the Wiskott-Aldrich (1974) (1)
- TWO COLOR FLOW CYTOMETRIC ANALYSIS OF CORD BLOOD LYMPHOCYTES (1987) (1)
- General Discussion 2 (1994) (1)
- Comparison of Anti-HIV-1 Retroviral Vectors and Their Use in a Gene Therapy Trial in Identical Twins (1995) (0)
- 685 IMMUNOGLOBULIN SECRETING CELLS IN THE BLOOD AND TONSIL OF NORMALS AND PATIENTS WITH IMMUNODEFICIENCY (1978) (0)
- Natural gene therapy: Somatic reversion in the Wiskott–Aldrich syndrome (2008) (0)
- 920 EFFECTS OF STEROID HORMONES ON IMMUNOGLOBULIN PRODUCTION IN ADULT AMD CORD BLOOD LYMPHOCYTES (1981) (0)
- EVALUATION OF RETROVIRAL MEDIATED GENE TRANSFER BY IN SITU HYBRIDIZATION (1987) (0)
- I Brief Definitive Reports I INFECTIOUS AGAMMAGLOBULINEM IA: TRANSMISSION OF IMMUNODEFICIENCY WITH GRAFTS OF AGAMMAGLOBULINEM IC CELLS (1974) (0)
- results of the first clinical gene therapy trial years and immune reaction to gene transfer components: Long-term Persistence and expression of the adenosine deaminase gene for twelve (2013) (0)
- Corrigendum: Retroviral transfer of acid α-glucosidase cDNA to enzyme-deficient myoblasts results in phenotypic spread of the genotypic correction by both secretion and fusion (Human Gene Therapy (1997) 8, 13 (1555-1563)) (1998) (0)
- Human gene marker/therapy clinical protocols. (2000) (0)
- AbstractDevelopment of gene therapy for mesothelioma using the Herpes simplex thymidine kinase suicide gene system (1996) (0)
- Neel Distinguished Research Lecturer: Where We Stand with Gene Therapy (1997) (0)
- Clinical Protocol Amendment to Clinical Research Project Project 90-C-195 (1999) (0)
- AN EVALUATION OF THE MECHANISMS OF T CELL-MEDIATED CYTOTOXICITY BY HOLGER KIRCHNER AND R. MICHAEL BLAESE (2003) (0)
- SPLICE SITE MUTATIONS IN THE WISKOTT ALDRICH SYNDROME. • 59 (1996) (0)
- Retroviral-Mediated Transfer andExpression of the Common Gamma Chain intoHuman Hematopoietic Progenitors (1999) (0)
- Human gene marker/therapy clinical protocols. (1996) (0)
- The Effect of Mycobacteriumbovis(BacillusCalmetteGuërin) on Macrophage RandomMigration,Chemotaxis,and Pinocytosis1 (1976) (0)
- features (see comments) clinical of a subset of patients with distinctive immunophenotypic and Characterization of common variable immunodeficiency: identification (2011) (0)
- Reversal of Common Variable Hypogammaglobulinemia-Associated Suppressor Cell Activity by Specific Carbohydrates (1985) (0)
- IMMUNOGLOBULIN CLASS SPECIFIC SUPPRESSOR T CELLS (1977) (0)
- In situ gene delivery for cancer therapy (1995) (0)
- Disorders of the immunoglobulin A system in hereditary sensory neuropathy. (1973) (0)
- GENE THERAPY (1996) (0)
- Deaminase Deficiency With Severe Combined Immune Deficiency Caused by Adenosine Directed Gene Transfer for a Patient - Successful Peripheral T-Lymphocyte (2011) (0)
- Monocyte Contrasuppression of EBV-Immune Regulatory T Cells (1985) (0)
- The wiskott aldrich syndrome gene localization and carrier detection with restriction fragment length polymorphisms (1986) (0)
- Antibodies to nucleic acids deficiency states in congenital immune (1976) (0)
- The mononuclear phagocyte system: the heart of host defense. (1986) (0)
- Contribution of B and T lymphocytes to in vitro chicken proliferative spleen cell reactions to antigens. (1973) (0)
- FAVORABLE RESPONSE TO IVIgG IN A WISCOTT-ALDRICH SYNDROME INFANT WITH SEVERE THROMBOCYTOPENIA REFRACTORY TO SPLENECTOMY (1987) (0)
- 951 IMPAIRED SPECIFIC IN VITRO ANTIBODY RESPONSES IN PATIENTS WITH ATAXIA TELANGIECTASIA (A-T) (1981) (0)
- Terapia genowa nowotworow i AIDS (1997) (0)
- 85. Von Willebrand Factor (VWF) Gene Targeting by Double_Strand Break Enhanced Homologous Recombination (2006) (0)
- Gene therapy of cancer. (1994) (0)
- OVERCORNING THE OBSTACLES (1997) (0)
- 1040. Towards Gene Correction Therapy for Wiskott-Aldrich Syndrome Using Designed Zinc Finger Endonucleases (2006) (0)
- Gene Therapy for Cancer Inserted genes could in theory arrest tumor growth or even AIDS (0)
- Gene Therapy for Immunodeficiency and Cancer (1993) (0)
- IDF MEDICAL ADVISORY COMMITTEE (2013) (0)
- Wait-effect in tumor-destructive therapy (1993) (0)
- Alternative splicing of the Wiskott-Aldrich syndrome (WAS) gene may affect phenotype (1996) (0)
- STUDIES OF MONOCYTE Fc RECEPTOR AVIDITY AND MONOCYTE MEDIATED ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY (MMADCC) IN MAN (1977) (0)
- IMMUNODEFICIENCY IN LYMPHOHISTIOCYTOSIS: DEFECTIVE CELLULAR IMMUNITY IN ASSOCIATION WITH HYPERLIPIDEMIA (1977) (0)
- Human gene marker/therapy clinical protocols. (1999) (0)
- ESTABLISHMENT AND CHARACTERIZATION OF ADENOSINE DEAMINASE (ADA)-DEFICIENT T CELL LINES (1987) (0)
- Prospects for gene therapy of human disease. (1991) (0)
- patient with Wiskott-Aldrich syndrome Unprecedented diversity of genotypic revertants in lymphocytes of a (2012) (0)
- SPONTANEOUS CYTOTOXICITY BY HUMAN PERIPHERAL BLOOD LYMPHOCYTES DUE TO A TIME DEPENDENT LOSS OF SUPPRESSOR CELLS (1977) (0)
- New approaches in the therapy of immunodeficiency. (1993) (0)
- Spontaneous Cytotoxicity (1979) (0)
- Rapid Publication (2003) (0)
- immunodeficiency Retroviral-mediated gene correction for X-linked severe combined (2011) (0)
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