R. R. Macdonald Senior

R. R. Macdonald Senior's AcademicInfluence.com Rankings

Philosophy

#7820

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#11080

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Logic

#4853

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#6184

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philosophy Degrees

R. R. Macdonald Senior

Biology

#10554

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#13887

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Cell Biology

#503

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#515

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Molecular Biology

#1544

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#1571

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Biochemistry

#1675

World Rank

#1810

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biology Degrees

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Philosophy
Biology

R. R. Macdonald Senior's Degrees

Doctorate Medicine Stanford University

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R. R. Macdonald Senior's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

MMP-9/Gelatinase B Is a Key Regulator of Growth Plate Angiogenesis and Apoptosis of Hypertrophic Chondrocytes (1998) (1786)
Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. (1997) (1481)
Interleukin-13 Induces Tissue Fibrosis by Selectively Stimulating and Activating Transforming Growth Factor β1 (2001) (919)
MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis. (2002) (838)
Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms. (2000) (808)
Matrix metalloproteinase-9 in lung remodeling. (2003) (589)
Platelet-derived growth factor and transforming growth factor-beta enhance tissue repair activities by unique mechanisms (1989) (558)
Human 92- and 72-kilodalton type IV collagenases are elastases. (1991) (542)
Chemotaxis of monocytes and neutrophils to platelet-derived growth factor. (1982) (525)
Chemotactic activity of elastin-derived peptides. (1980) (507)
Neutral metalloproteinases produced by human mononuclear phagocytes. Enzyme profile, regulation, and expression during cellular development. (1990) (469)
Elastin fragments drive disease progression in a murine model of emphysema. (2006) (450)
Targeted Disruption of the Matrix Metalloproteinase-9 Gene Impairs Smooth Muscle Cell Migration and Geometrical Arterial Remodeling (2002) (432)
Platelet factor 4 is chemotactic for neutrophils and monocytes. (1981) (417)
The Serpin α1-Proteinase Inhibitor Is a Critical Substrate for Gelatinase B/MMP-9 In Vivo (2000) (375)
Val-Gly-Val-Ala-Pro-Gly, a repeating peptide in elastin, is chemotactic for fibroblasts and monocytes (1984) (359)
Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13-induced inflammation and remodeling. (2002) (340)
Fragments of extracellular matrix as mediators of inflammation. (2008) (335)
The induction of pulmonary emphysema with human leukocyte elastase. (2015) (328)
Matrix Metalloproteinases 9 and 2 Are Necessary for the Migration of Langerhans Cells and Dermal Dendritic Cells from Human and Murine Skin1 (2002) (308)
Matrix Metalloproteinase Gelatinase B (MMP-9) Coordinates and Effects Epithelial Regeneration* (2002) (282)
Clinical experience with theophylline. Relarionships between dosage, serum concentration, and toxicity. (1976) (281)
Matrix metalloproteinases. Matrix degradation and more. (1999) (263)
Chemotactic activity of platelet alpha granule proteins for fibroblasts (1983) (262)
Recruitment of osteoclast precursors by purified bone matrix constituents (1982) (261)
Characterization of hematopoietic progenitor mobilization in protease-deficient mice. (2004) (258)
The induction of emphysema with elastase. II. Changes in connective tissue. (1976) (256)
In vivo incisional wound healing augmented by platelet-derived growth factor and recombinant c-sis gene homodimeric proteins (1988) (249)
Proteolysis by neutrophils. Relative importance of cell-substrate contact and oxidative inactivation of proteinase inhibitors in vitro. (1982) (246)
Gelatinase B–deficient Mice Are Resistant to Experimental Bullous Pemphigoid (1998) (245)
Effects of fibrinogen derivatives upon the inflammatory response. Studies with human fibrinopeptide B. (1986) (239)
The Structural Basis for the Elastolytic Activity of the 92-kDa and 72-kDa Gelatinases (1996) (230)
Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage metalloelastase. (1992) (207)
Human alveolar macrophages produce a fibroblast-like collagenase and collagenase inhibitor. (1985) (205)
Smooth muscle-mediated connective tissue remodeling in pulmonary hypertension. (1987) (197)
Elastin Degradation by Matrix Metalloproteinases (1997) (191)
Gelatinase B is required for alveolar bronchiolization after intratracheal bleomycin. (2000) (181)
The elastin receptor shows structural and functional similarities to the 67-kDa tumor cell laminin receptor. (1989) (180)
Elastin binds to a multifunctional 67-kilodalton peripheral membrane protein. (1989) (176)
A critical role for neutrophil elastase in experimental bullous pemphigoid. (2000) (175)
Activation of the 92-kDa Gelatinase by Stromelysin and 4-Aminophenylmercuric Acetate (1995) (168)
Elastase release from human alveolar macrophages: comparison between smokers and nonsmokers. (1977) (167)
Nicotine is chemotactic for neutrophils and enhances neutrophil responsiveness to chemotactic peptides. (1984) (164)
Mice that lack matrix metalloproteinase-9 display delayed wound healing associated with delayed reepithelization and disordered collagen fibrillogenesis. (2009) (153)
Chemotactic responses of fibroblasts to tropoelastin and elastin-derived peptides. (1982) (148)
Neutrophil emigration in the lungs, peritoneum, and skin does not require gelatinase B. (1999) (147)
Neutrophils from MMP‐9‐ or neutrophil elastase‐deficient mice show no defect in transendothelial migration under flow in vitro (2002) (147)
Matrix metalloproteinase-9 activates TGF-β and stimulates fibroblast contraction of collagen gels. (2014) (146)
Alpha 1-proteinase inhibitor is a neutrophil chemoattractant after proteolytic inactivation by macrophage elastase. (1988) (145)
Matrix metalloproteinase deficiencies affect contact hypersensitivity: stromelysin-1 deficiency prevents the response and gelatinase B deficiency prolongs the response. (1999) (138)
Macrophage fusion, giant cell formation, and the foreign body response require matrix metalloproteinase 9 (2009) (137)
Matrix Metalloproteinase-9 Deficiency Results in Enhanced Allergen-Induced Airway Inflammation1 (2004) (137)
Degradation of entactin by matrix metalloproteinases. Susceptibility to matrilysin and identification of cleavage sites. (1993) (131)
Matrilysin is much more efficient than other matrix metalloproteinases in the proteolytic inactivation of alpha 1-antitrypsin. (1994) (129)
The inhibitory complex of human alpha 1-proteinase inhibitor and human leukocyte elastase is a neutrophil chemoattractant (1988) (122)
The role of matrix metalloproteinase-9 in cigarette smoke-induced emphysema. (2011) (119)
Platelet-derived growth factor promotes polymorphonuclear leukocyte activation. (1984) (114)
Elastin degradation by human alveolar macrophages. A prominent role of metalloproteinase activity. (1989) (114)
Elastase of U-937 monocytelike cells. Comparisons with elastases derived from human monocytes and neutrophils and murine macrophagelike cells. (1982) (113)
Differential stimulation of collagenase and chemotactic activity in fibroblasts derived from rat wound repair tissue and human skin by growth factors (1989) (111)
Interactions of pulmonary surfactant protein D (SP-D) with human blood leukocytes. (1995) (109)
Characterization of the mannose/fucose receptor on human mononuclear phagocytes. (1982) (106)
Laminin isoforms and lung development: all isoforms are not equal. (2006) (105)
Serum Elastase Inhibitor Deficiency and αl-Antitrypsin Deficiency in Patients with Obstructive Emphysema (1969) (103)
Receptor-mediated binding and internalization of leukocyte elastase by alveolar macrophages in vitro. (1979) (103)
A Site on Laminin α5, AQARSAASKVKVSMKF, Induces Inflammatory Cell Production of Matrix Metalloproteinase-9 and Chemotaxis1 (2003) (103)
Characterization of biologically active domains on elastin: identification of a monoclonal antibody to a cell recognition site. (1986) (96)
Neutrophil Elastase Cleaves Laminin-332 (Laminin-5) Generating Peptides That Are Chemotactic for Neutrophils* (2008) (96)
Synergy between a plasminogen cascade and MMP-9 in autoimmune disease. (2005) (96)
Epithelial laminin alpha5 is necessary for distal epithelial cell maturation, VEGF production, and alveolization in the developing murine lung. (2005) (89)
Membrane‐type 1 matrix metalloproteinase is required for normal alveolar development (2005) (89)
Extracellular matrix injury during lung inflammation. (1987) (88)
Laminin alpha 5 is required for lobar septation and visceral pleural basement membrane formation in the developing mouse lung. (2002) (87)
Developmental regulation of the human cathepsin G gene in myelomonocytic cells. (1990) (85)
Studies of leukotriene B4-specific binding and function in rat polymorphonuclear leukocytes: absence of a chemotactic response. (1985) (85)
Overexpression of Stat3C in Pulmonary Epithelium Protects against Hyperoxic Lung Injury1 (2005) (80)
Determination of oxidized alpha-1-proteinase inhibitor in serum. (1982) (78)
Neutrophils show chemotaxis to type IV collagen and its 7S domain and contain a 67 kD type IV collagen binding protein with lectin properties. (1989) (77)
Proteinases secreted by human mononuclear phagocytes. (1991) (76)
Clara cell adhesion and migration to extracellular matrix (2008) (76)
Ablation of Matrix Metalloproteinase-9 Increases Severity of Viral Myocarditis in Mice (2008) (75)
Chemotactic factor inactivators of human granulocytes. (1977) (75)
Fibrinogen-derived peptide B beta 1-42 is a multidomained neutrophil chemoattractant (1988) (74)
Characterization of mouse alveolar epithelial cell monolayers. (2009) (72)
Mouse strain modulates the role of the ciliated cell in acute tracheobronchial airway injury-distal airways. (2002) (72)
Maintenance of glomerular filtration barrier integrity requires laminin alpha5. (2010) (72)
Expression of Laminin α3, α4, and α5 Chains by Alveolar Epithelial Cells and Fibroblasts (1998) (68)
Dissociation of the chemotactic and mitogenic activities of platelet- derived growth factor by human neutrophil elastase (1985) (68)
Distal airways in mice exposed to cigarette smoke: Nrf2-regulated genes are increased in Clara cells. (2008) (66)
Tissue-specific expression and developmental regulation of the human fgr proto-oncogene (1989) (65)
PDGF AA homodimers are potent chemoattractants for fibroblasts and neutrophils, and for monocytes activated by lymphocytes or cytokines. (1992) (63)
The serpin-enzyme complex (SEC) receptor mediates the neutrophil chemotactic effect of alpha-1 antitrypsin-elastase complexes and amyloid-beta peptide. (1992) (63)
Roles of a prostaglandin E‐type receptor, EP3, in upregulation of matrix metalloproteinase‐9 and vascular endothelial growth factor during enhancement of tumor metastasis (2009) (62)
Gelatinase B (MMP-9) is not essential in the normal kidney and does not influence progression of renal disease in a mouse model of Alport syndrome. (2000) (62)
Elastin in lung development and disease. (1995) (61)
Extracellular matrix-specific induction of elastogenic differentiation and maintenance of phenotypic stability in bovine ligament fibroblasts (1984) (60)
Neutrophil elastase cleaves the murine hemidesmosomal protein BP180/type XVII collagen and generates degradation products that modulate experimental bullous pemphigoid. (2012) (60)
12-o-Tetradecanoyl-phorbol-13-acetate-differentiated U937 cells express a macrophage-like profile of neutral proteinases. High levels of secreted collagenase and collagenase inhibitor accompany low levels of intracellular elastase and cathepsin G. (1986) (60)
Cathepsin G in human mononuclear phagocytes: comparisons between monocytes and U937 monocyte-like cells. (1984) (58)
Clara cells impact the pulmonary innate immune response to LPS. (2007) (54)
Digestion of the fifth component of complement by leukocyte enzymes. Sequential generation of chemotactic activities for leukocytes and for tumor cells. (1979) (53)
Neutral proteinases from human inflammatory cells. A critical review of their role in extracellular matrix degradation. (1983) (53)
Laser capture microdissection and real-time reverse transcriptase/ polymerase chain reaction of bronchiolar epithelium after bleomycin. (2001) (51)
Smoking and nicotine exposure delay development of collagen-induced arthritis in mice (2009) (50)
Rationale and Design of the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) Study. Sarcoidosis Protocol. (2015) (50)
Gelatinase B(MMP-9) an apoptotic factor in diabetic transgenic mice (2003) (50)
Postpneumonectomy lung growth: a model of reinitiation of tropoelastin and type I collagen production in a normal pattern in adult rat lung. (1996) (46)
A Chemotactic Peptide from Laminin α5 Functions as a Regulator of Inflammatory Immune Responses via TNFα-mediated Signaling1 (2005) (45)
Neutral proteinase expression by human mononuclear phagocytes: a prominent role of cellular differentiation. (1992) (45)
Membrane type 1 matrix metalloproteinase is necessary for distal airway epithelial repair and keratinocyte growth factor receptor expression after acute injury. (2007) (45)
The carboxyl-terminal tridecapeptide of platelet factor 4 is a potent chemotactic agent for monocytes. (1982) (43)
Entactin expression by rat lung and rat alveolar epithelial cells. (1996) (42)
Recombinant SP-D carbohydrate recognition domain is a chemoattractant for human neutrophils. (1999) (41)
Tumor necrosis factor-alpha from macrophages enhances LPS-induced clara cell expression of keratinocyte-derived chemokine. (2008) (41)
Biochemical quantitation of the chemotactic factor inactivator activity in human serum. (1979) (40)
Brain-derived growth factor is a chemoattractant for fibroblasts and astroglial cells. (1986) (39)
Alveolar cell carcinoma. An electron microscopic study. (1969) (37)
Different Roles for Matrix Metalloproteinase‐2 and Matrix Metalloproteinase‐9 in the Pathogenesis of Cardiac Allograft Rejection (2005) (37)
Fibrinogen-derived peptide B beta 1-42 is a multidomained neutrophil chemoattractant. (1988) (37)
Appearance of chemotactic responsiveness to elastin peptides by developing fetal bovine ligament fibroblasts parallels the onset of elastin production (1984) (36)
A chemotactic peptide from laminin alpha 5 functions as a regulator of inflammatory immune responses via TNF alpha-mediated signaling. (2005) (36)
A new method for determination of elastolytic activity using (14C) labeled elastin and its application to leukocytic elastase. (1975) (35)
Expression Patterns of Laminin α 1 and α 5 in Human Lung during Development (2000) (34)
Extracellular matrix metalloproteinase inducer is increased in smokers' bronchoalveolar lavage fluid. (2003) (34)
Binding and degradation of elastin by the staphylolytic enzyme lysostaphin. (1995) (34)
Bronchiolar chemokine expression is different after single versus repeated cigarette smoke exposure (2008) (32)
Human C5a and C5a des Arg exhibit chemotactic activity for fibroblasts. (1988) (31)
Human alveolar macrophages secrete an inhibitor of metalloproteinase elastase. (1987) (30)
Increased basigin in bleomycin-induced lung injury. (2003) (30)
Inhibition of Obliterative Airway Disease Development in Murine Tracheal Allografts by Matrix Metalloproteinase‐9 Deficiency (2005) (27)
Laser capture microdissection and mRNA characterization of mouse airway epithelium: methodological considerations. (2004) (26)
Measurement of elastase activity by elastin agar and its use in the detection of antitrypsin deficiency. (1971) (25)
Neither SP-A nor NH2-terminal domains of SP-A can substitute for SP-D in regulation of alveolar homeostasis. (2006) (25)
The elastase activity of alveolar macrophages: measurements using synthetic substrates and elastin. (1976) (25)
The effects of proteolytic enzymes on the tensile strength of human lung. (2015) (25)
Inhibition of obliterative airway disease development in murine tracheal allografts by matrix metalloproteinase-9 deficiency. (2004) (25)
Expression patterns of laminin alpha1 and alpha5 in human lung during development. (2000) (22)
Theophylline toxicity due to impaired theophylline degradation. (1974) (22)
Lung development in laminin γ2 deficiency: abnormal tracheal hemidesmosomes with normal branching morphogenesis and epithelial differentiation (2006) (21)
Comparison of the elastolytic effects of human leukocyte elastase and porcine pancreatic elastase. (1976) (21)
Extracellular matrix metalloproteinase inducer in interstitial pneumonias. (2006) (20)
Expression of laminin alpha3, alpha4, and alpha5 chains by alveolar epithelial cells and fibroblasts. (1998) (19)
Growth factors in fibrotic diseases. (1987) (19)
Smoke particulates stress lung cells (2008) (18)
Macrophage Elastase (MMP-12) (1998) (18)
Cell injury and repair. (1981) (18)
Functional Consequences of Cell Type-Restricted Expression of Laminin α5 in Mouse Placental Labyrinth and Kidney Glomerular Capillaries (2012) (16)
OBTAINING AND CULTURING HUMAN AND ANIMAL ALVEOLAR MACROPHAGES (1981) (15)
Keratinocyte-Targeted Expression of Human Laminin γ2 Rescues Skin Blistering and Early Lethality of Laminin γ2 Deficient Mice (2012) (15)
The role of elastases in the development of emphysema (1978) (14)
Laminin α-chain expression and basement membrane formation by MLE-15 respiratory epithelial cells (2002) (14)
111Indium-labeled human alveolar macrophages and monocytes: function and ultrastructure. (1980) (13)
Comparison of the elastolytic effects of human leukocyte elastase and porcine pancreatic elastase. (1976) (13)
Gelatinase B deficiency does not protect against lipopolysaccharide-induced acute lung injury. (1999) (12)
The fibrotic matrix in control: does the extracellular matrix drive progression of idiopathic pulmonary fibrosis? (2012) (12)
Measuring small airways in transverse CT images correction for partial volume averaging and airway tilt. (2010) (12)
Chemotaxis of Monocytes and Neutrophils (1982) (11)
Introduction: the matrix metalloproteinase family. (1992) (10)
Laminin γ2 knockout mice rescued with the human protein exhibit enamel maturation defects. (2016) (9)
Laminin alpha-chain expression and basement membrane formation by MLE-15 respiratory epithelial cells. (2002) (9)
Rationale and Design of the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis Study. Alpha-1 Protocol. (2015) (9)
Platelet alpha-granule protein-induced chemotaxis of inflammatory cells and fibroblasts. (1989) (8)
Effects of hyperoxia on fibrinogen metabolism and clotting factors in rabbits. (1974) (6)
Aspects of respiratory care pertinent to the radiologist. (1973) (4)
Recombinant SP-D carbohydrate recognition domain is a chemoattractant for human neutrophils. (1999) (4)
The immunopathologic basis of hypersensitivity pneumonitis. (1978) (3)
Inflammatory mediators of pulmonary tissue injury (1991) (3)
Chemotactic Factor Inactivators of Human (1977) (2)
The role of elastases in the development of emphysema. (1978) (2)
Tracheobronchomalacia as a Co-Morbidity of Asthma and as an Alternate Diagnosis to Asthma (2009) (1)
Modulation of macrophage elastase activity identification and quantification of a metalloproteinase elastase inhibitor released by human alveolar macrophages (1985) (1)
Alveolar macrophage secrets. (1981) (1)
Correlation between Emphysema Index (EI) and Health-Related Quality of Life (HRQL) Scores in Heavy Smokers. (2009) (1)
So Long: It's Been Great Knowing You (1993) (0)
clinical impHcationsofbasicresearch Extracellular Matrix Injury during Lung Inflammation * (0)
Different roles for matrix metalloproteinase-2 and -9 in the pathogenesis of cardiac allograft rejection (2004) (0)
Significant prolongation of murine cardiac allograft survival by inhibition of matrix metalloproteinase-2 (2002) (0)
8-Year Emphysema Progression In Former Smokers Is Predicted By 2-Year Progression And Associated With Biomarkers Of Lung Injury And Inflammation (2012) (0)
Matrix Metalloproteinase-9 Affects Three-Dimensional Collagen Gel Contraction (2006) (0)
Dynamic Chest Computed Tomography (CT) Identifies Airway Malacia In Difficult To Control Asthma (DCA): A New Asthma Phenotype (2011) (0)
Metalloproteinase-9-deficient mice are resistant to bullous pemphigoid (1998) (0)
Let 'Er Rip (2012) (0)
MT1_MMP is required for repair of acute airway injury (2006) (0)
Laminin‐332 deficient mice present defects during tooth enamel development (LB547) (2014) (0)
Chemotactic for Neutrophils ( Laminin-5 ) Generating Peptides That Are Neutrophil Elastase Cleaves Laminin-332 Glycobiology and Extracellular Matrices : (2008) (0)
InjuryEpithelium Protects against Hyperoxic Lung Overexpression of Stat3C in Pulmonary (2005) (0)
Alive, Well, and Growing: A Report from the Editors (1990) (0)
Insights from RNA-sequencing of bronchoalveolar lavage cells in a large sarcoidosis cohort (2017) (0)
Theophylline Toxicity due to Impaired Theophylline Degradation1, 2 (2015) (0)
Regional Alveolar Macrophage Activation And Protease Production In Emphyema (2010) (0)
Prolongation of cardiac allograft survival by abrogation of matrix metalloproteinase-2 (2003) (0)
THE RELATION OF CERVICAL MUCUS PROTEINS TO SPERM PENETRABILITY (2005) (0)
Abrogation of obliterative airway disease in murine tracheal allografts by inhibition of matrix metalloproteinases-2 and -9 (2003) (0)
I. Neutrophils, Their Elastases and Inhibitors in the Lungs (2015) (0)
Corrections For Tilt And Partial Volume Averaging Improve Correlations Between Spirometry And Human Airway Wall Thickness On CT Scan In COPD (2011) (0)
chemoattractant for human neutrophils Recombinant SP-D carbohydrate recognition domain is a (2016) (0)
Peripheral Blood Monocyte MMP-14 And EMMPRIN Expression Are Associated With The Presence And Progression Of Emphysema (2012) (0)
Laminin-332 (A.K.A. Lm-5) is Required for Maintaining Normal Lung Structure and Mechanics (2010) (0)
InjuryProtects against Hyperoxic Lung Overexpression of Stat3C in Pulmonary (2013) (0)
The Red journal at 25. A perspective from the founding editors. (2014) (0)
Smoking and nicotine exposure delays development of arthritis in animal model (99.24) (2009) (0)
Lung Laminin-332 Deficiency Enhances Engraftment of Tumor Cells into the Lung but Retards Tumor Cell Growth (2012) (0)
CT Airway Dimensions And Emphysema Severity (2010) (0)
Off and running: a progress report from the AJRCMB. (1988) (0)
Regional And Longitudinal Changes In Emphysema Severity And Small Airway Wall Thickness (WT) In A Cohort Of Former Heavy Smokers From The National Lung Screening Trial (NLST) (2012) (0)
Mice Lacking Pulmonary Laminin-332 (a.k.a. Lm-5) Can Survive into Adulthood. (2009) (0)
Lung elastin and elastases in COPD (2002) (0)
Matrix Metalloproteinase-9 Deficiency Results in Enhanced Allergen-Induced Airway Inflammation 1 (2004) (0)
Relationship of Monocyte EMMPRIN Expression with Emphysema and COPD Severity. (2009) (0)
Pancreatic, liver, gastrointestinal, and renal diseases (1992) (0)
Interactions between Inflammatory Cells and Extracellular Matrix (1992) (0)
Monocyte MMP-14 And EMMPRIN Production Is Elevated In Emphysema (2010) (0)

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Published Works

What Schools Are Affiliated With R. R. Macdonald Senior?

R. R. Macdonald Senior's AcademicInfluence.com Rankings