R. Paul Robertson

R. Paul Robertson's AcademicInfluence.com Rankings

R. Paul Robertson

Biology

#3746

World Rank

#5688

Historical Rank

Endocrinology

#18

World Rank

#21

Historical Rank

biology Degrees

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Biology

R. Paul Robertson's Degrees

Doctorate Medicine University of Washington
PhD Physiology University of Washington

Why Is R. Paul Robertson Influential?

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According to Wikipedia, R. Paul Robertson is an American endocrinologist and former president and scientific director of the Pacific Northwest Diabetes Research Institute . He is a professor of medicine at the University of Minnesota. Robertson was the 2009 president, Medicine & Science of the Volunteer Board for the American Diabetes Association. His research interests focus on glucose regulation of pancreatic islet gene expression and the abnormal consequences on gene expression caused by glucose toxicity. He is also involved in metabolic studies of type 1 diabetic patients who have successfully received pancreas and pancreatic islet transplantation . He was elected to be the editor-in-chief for the Journal of Clinical Endocrinology and Metabolism of the Endocrine Society beginning January 2015.

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R. Paul Robertson's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

International trial of the Edmonton protocol for islet transplantation. (2006) (1482)
Chronic Oxidative Stress as a Central Mechanism for Glucose Toxicity in Pancreatic Islet Beta Cells in Diabetes* (2004) (1036)
How Do We Define Cure of Diabetes? (2009) (896)
Glucose toxicity in beta-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection. (2003) (888)
Glucolipotoxicity: Fuel Excess and β-Cell Dysfunction (2008) (886)
β-Cell Glucose Toxicity, Lipotoxicity, and Chronic Oxidative Stress in Type 2 Diabetes (2004) (756)
Minireview: Secondary β-Cell Failure in Type 2 Diabetes-A Convergence of Glucotoxicity and Lipotoxicity. (2002) (697)
Lessons Learned From More Than 1,000 Pancreas Transplants at a Single Institution (2001) (603)
Glucolipotoxicity: fuel excess and beta-cell dysfunction. (2008) (540)
Relationships between fasting plasma glucose levels and insulin secretion during intravenous glucose tolerance tests. (1976) (511)
Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants. (1999) (461)
Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes. (2004) (454)
Islet transplantation as a treatment for diabetes - a work in progress. (2004) (439)
Minireview: Secondary beta-cell failure in type 2 diabetes--a convergence of glucotoxicity and lipotoxicity. (2002) (368)
Inactivation of specific β cell transcription factors in type 2 diabetes. (2013) (358)
Diabetes, glucose toxicity, and oxidative stress: A case of double jeopardy for the pancreatic islet beta cell. (2006) (346)
A role for glutathione peroxidase in protecting pancreatic β cells against oxidative stress in a model of glucose toxicity (2002) (316)
Adrenergic Modulation of Basal Insulin Secretion in Man (1973) (237)
Effects of hemipancreatectomy on insulin secretion and glucose tolerance in healthy humans. (1990) (236)
Regulation of the insulin gene by glucose and fatty acids. (2006) (233)
Preservation of insulin mRNA levels and insulin secretion in HIT cells by avoidance of chronic exposure to high glucose concentrations. (1992) (232)
Autologous Islet Transplantation to Prevent Diabetes After Pancreatic Resection (1995) (231)
Oxidative Stress-mediated, Post-translational Loss of MafA Protein as a Contributing Mechanism to Loss of Insulin Gene Expression in Glucotoxic Beta Cells* (2005) (213)
Chronic exposure of HIT cells to high glucose concentrations paradoxically decreases insulin gene transcription and alters binding of insulin gene regulatory protein. (1993) (213)
Chronic oxidative stress as a mechanism for glucose toxicity of the beta cell in Type 2 diabetes (2007) (203)
The glucose receptor. A defective mechanism in diabetes mellitus distinct from the beta adrenergic receptor. (1973) (196)
A role for alpha-adrenergic receptors in abnormal insulin secretion in diabetes mellitus. (1976) (194)
Effects of tacrolimus (FK506) on human insulin gene expression, insulin mRNA levels, and insulin secretion in HIT-T15 cells. (1996) (192)
Detection, evaluation and treatment of diabetes mellitus in chronic pancreatitis: recommendations from PancreasFest 2012. (2013) (192)
Differentiating Glucose Toxicity From Glucose Desensitization: A New Message From the Insulin Gene (1994) (187)
Pancreatic islet β‐cell and oxidative stress: The importance of glutathione peroxidase (2007) (183)
Oxidative stress and impaired insulin secretion in type 2 diabetes. (2006) (177)
Pancreatic endocrine function in cystic fibrosis. (1991) (176)
Thyroid Dysfunction and Diabetes Mellitus: Two Closely Associated Disorders. (2019) (176)
The Insulin Gene Promoter: A Simplified Nomenclature (1995) (174)
A role for prostaglandin E in defective insulin secretion and carbohydrate intolerance in diabetes mellitus. (1977) (172)
Control of insulin secretion by catecholamines, stress, and the sympathetic nervous system. (1973) (168)
Prevention of diabetes for up to 13 years by autoislet transplantation after pancreatectomy for chronic pancreatitis. (2001) (165)
Preserved insulin secretion and insulin independence in recipients of islet autografts. (1992) (158)
Chronic exposure of betaTC-6 cells to supraphysiologic concentrations of glucose decreases binding of the RIPE3b1 insulin gene transcription activator. (1996) (158)
Pancreas and islet transplantation in type 1 diabetes. (2006) (151)
Effect of the two-layer (University of Wisconsin solution–perfluorochemical plus O2) method of pancreas preservation on human islet isolation, as assessed by the Edmonton Isolation Protocol1 (2002) (150)
Successful islet autotransplantation in humans: functional insulin secretory reserve as an estimate of surviving islet cell mass. (1998) (149)
beta-Cell-specific overexpression of glutathione peroxidase preserves intranuclear MafA and reverses diabetes in db/db mice. (2009) (149)
Antecedent hyperglycemia, not hyperlipidemia, is associated with increased islet triacylglycerol content and decreased insulin gene mRNA level in Zucker diabetic fatty rats. (2001) (148)
The reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to high glucose concentration is associated with the loss of RIPE3b1 and STF-1 transcription factor expression. (1995) (147)
Induction of Defective Insulin Secretion and Impaired Glucose Tolerance by Clonidine Selective Stimulation of Metabolic Alpha-adrenergic Pathways (1978) (147)
Basal expression of cyclooxygenase-2 and nuclear factor-interleukin 6 are dominant and coordinately regulated by interleukin 1 in the pancreatic islet. (1998) (142)
Intrahepatic islet transplantation in type 1 diabetic patients does not restore hypoglycemic hormonal counterregulation or symptom recognition after insulin independence. (2002) (141)
Total pancreatectomy and islet autotransplantation in chronic pancreatitis: recommendations from PancreasFest. (2014) (140)
Pancreas and islet transplantation for patients with diabetes. (2000) (137)
Pancreatic Islet Transplantation in Humans: Recent Progress and Future Directions. (2018) (134)
Factors Predicting Outcomes After a Total Pancreatectomy and Islet Autotransplantation Lessons Learned From Over 500 Cases. (2015) (130)
Glucagon, catecholamine and pancreatic polypeptide secretion in type I diabetic recipients of pancreas allografts. (1990) (127)
Differentiation of glucose toxicity from beta cell exhaustion during the evolution of defective insulin gene expression in the pancreatic islet cell line, HIT-T15. (1997) (126)
Systemic venous drainage of pancreas allografts as independent cause of hyperinsulinemia in type I diabetic recipients. (1990) (125)
Lipoxygenase pathway in islet endocrine cells. Oxidative metabolism of arachidonic acid promotes insulin release. (1983) (124)
Dominance of cyclooxygenase-2 in the regulation of pancreatic islet prostaglandin synthesis. (1998) (123)
A 10‐Year Experience with 290 Pancreas Transplants at a Single Institution (1989) (115)
Type II Diabetes, Glucose “Non-Sense,” and Islet Desensitization (1989) (113)
Cyclosporin-Induced Inhibition of Insulin Secretion in Isolated Rat Islets and HIT Cells (1986) (110)
INHIBITORY EFFECTS OF IMMUNOSUPPRESSIVE DRUGS ON INSULIN SECRETION FROM HIT-T15 CELLS AND WISTAR RAT ISLETS1 (2002) (109)
Insulin-secreting cell lines: classification, characteristics and potential applications. (1996) (109)
In vivo prevention of hyperglycemia also prevents glucotoxic effects on PDX-1 and insulin gene expression. (1999) (105)
Islet Transplantation a Decade Later and Strategies for Filling a Half-Full Glass (2010) (104)
Zinc, Not Insulin, Regulates the Rat α-Cell Response to Hypoglycemia In Vivo (2007) (104)
Regulation of α-Cell Function by the β-Cell in Isolated Human and Rat Islets Deprived of Glucose: the “Switch-off” Hypothesis (2004) (101)
Defective Glucagon Secretion During Sustained Hypoglycemia Following Successful Islet Allo- and Autotransplantation in Humans (1997) (101)
Determinants of glucose toxicity and its reversibility in the pancreatic islet beta-cell line, HIT-T15. (2000) (101)
Characterization and regulation of prostaglandin and leukotriene receptors: an overview. (1986) (100)
Systemic Venous Drainage of Pancreas Allografts as Independent Cause of Hyperinsulinemia in Type I Diabetic Recipients (1990) (98)
G Proteins and Modulation of Insulin Secretion (1991) (95)
β-Cell deterioration during diabetes: what's in the gun? (2009) (94)
Regulation of α-Cell Function by the β-Cell During Hypoglycemia in Wistar Rats: the “Switch-off” Hypothesis (2004) (89)
Prostaglandin E2 Mediates Inhibition of Insulin Secretion by Interleukin-1β* (1999) (86)
Inhibition of Prostaglandin E Synthesis Augments Glucose-induced Insulin Secretion in Cultured Pancreas (1981) (85)
Inhibition of in vivo insulin secretion by prostaglandin E1. (1974) (84)
Hyperproinsulinemia is associated with increased beta cell demand after hemipancreatectomy in humans. (1996) (84)
Morphological and Functional Characterization of βTC-6 Cells—an Insulin-Secreting Cell Line Derived From Transgenic Mice (1995) (84)
Inhibition of Interleukin-1β-Induced COX-2 and EP3 Gene Expression by Sodium Salicylate Enhances Pancreatic Islet β-Cell Function (2002) (84)
Receptor-Mediated Adenylate Cyclase—Coupled Mechanism for PGE2 Inhibition of Insulin Secretion in HIT Cells (1987) (84)
Insulin Secretion and cAMP Metabolism in HIT Cells: Reciprocal and Serial Passage-Dependent Relationships (1989) (82)
Increased oxygen consumption rates in response to high glucose detected by a novel oxygen biosensor system in non-human primate and human islets. (2005) (82)
Plasma prostaglandin E in patients with cancer with and without hypercalcemia. (1976) (79)
Accelerated triglyceride secretion. A metabolic consequence of obesity. (1973) (78)
Elevated prostaglandins and suppressed parathyroid hormone associated with hypercalcemia and renal cell carcinoma. (1975) (73)
Prostaglandin: increased production by renal cell carcinoma. (1977) (73)
Relationship between diabetes and obesity 9 to 18 years after hemipancreatectomy and transplantation in donors and recipients. (2002) (72)
Pancreas transplantation for patients with type 1 diabetes. (2003) (72)
Zinc, not insulin, regulates the rat alpha-cell response to hypoglycemia in vivo. (2007) (71)
Ebselen Treatment Prevents Islet Apoptosis, Maintains Intranuclear Pdx-1 and MafA Levels, and Preserves β-Cell Mass and Function in ZDF Rats (2013) (70)
Prostaglandins as modulators of pancreatic islet function. (1979) (70)
The GENNID Study: A resource for mapping the genes that cause NIDDM (1996) (68)
Consequences on beta-cell function and reserve after long-term pancreas transplantation. (2004) (68)
Regulation of alpha-cell function by the beta-cell during hypoglycemia in Wistar rats: the "switch-off" hypothesis. (2004) (68)
Estimation of β-Cell Mass by Metabolic Tests (2007) (68)
Prostaglandin E-induced heterologous desensitization of hepatic adenylate cyclase. Consequences on the guanyl nucleotide regulatory complex. (1983) (65)
AN INTEGRATED VIEW OF β-CELL DYSFUNCTION IN TYPE-II DIABETES (1996) (65)
Suppression of plasma catecholamines and flushing by clonidine in man. (1978) (64)
Increase in Gs and cyclic AMP generation in HIT cells. Evidence that the 45-kDa alpha-subunit of Gs has greater functional activity than the 52-kDa alpha-subunit. (1989) (63)
Restoration of the Acute Insulin Response by Sodium Salicylate: A Glucose Dose-related Phenomenon (1978) (61)
Successful islet transplantation for patients with diabetes--fact or fantasy? (2000) (60)
ATP-Sensitive K+ Channel Mediates the Zinc Switch-Off Signal for Glucagon Response During Glucose Deprivation (2009) (60)
Paradoxical inhibition of insulin secretion by glucose in human diabetes mellitus. (1979) (58)
Regulation of alpha-cell function by the beta-cell in isolated human and rat islets deprived of glucose: the "switch-off" hypothesis. (2004) (58)
Neuroendocrine modulation of calcitonin and parathyroid hormone in man. (1978) (57)
Metabolic characterization of long-term successful pancreas transplants in type I diabetes. (1996) (57)
Eicosanoids as Pluripotential Modulators of Pancreatic Islet Function (1988) (56)
Estimation of beta-cell mass by metabolic tests: necessary, but how sufficient? (2007) (55)
Adenoviral Overexpression of the Glutamylcysteine Ligase Catalytic Subunit Protects Pancreatic Islets against Oxidative Stress* (2004) (54)
Antioxidant drugs for treating beta-cell oxidative stress in type 2 diabetes: glucose-centric versus insulin-centric therapy. (2010) (53)
Normoglycemia and preserved insulin secretory reserve in diabetic patients 10-18 years after pancreas transplantation. (1999) (51)
d-Glyceraldehyde Causes Production of Intracellular Peroxide in Pancreatic Islets, Oxidative Stress, and Defective Beta Cell Function via Non-mitochondrial Pathways* (2004) (50)
Suppression of Adenylate Kinase Catalyzed Phosphotransfer Precedes and Is Associated with Glucose-induced Insulin Secretion in Intact HIT-T15 Cells* (1996) (50)
RESTORED HYPOGLYCEMIC COUNTERREGULATION IS STABLE IN SUCCESSFUL PANCREAS TRANSPLANT RECIPIENTS FOR UP TO 19 YEARS AFTER TRANSPLANTATION1 (2001) (49)
Beta cell nuclear musculoaponeurotic fibrosarcoma oncogene family A (MafA) is deficient in type 2 diabetes (2012) (49)
Arachidonic acid metabolite regulation of insulin secretion. (1986) (49)
Autonomic epilepsy: clonidine blockade of paroxysmal catecholamine release and flushing. (1978) (48)
Assessment of β-Cell Mass and α- and β-Cell Survival and Function by Arginine Stimulation in Human Autologous Islet Recipients (2014) (47)
Inactivation of specific b cell transcription factors in type 2 diabetes (2018) (46)
A role for the lipoxygenase pathway of arachidonic acid metabolism in glucose- and glucagon-induced insulin secretion. (1983) (46)
Lipoxygenation of arachidonic acid: a pivotal step in stimulus-secretion coupling in the pancreatic beta cell. (1982) (46)
Pertussis Toxin–Sensitive G Protein Mediation of PGE2 Inhibition of cAMP Metabolism and Phasic Glucose-Induced Insulin Secretion in HIT Cells (1989) (46)
Inhibition of glucagon‐stimulated hepatic glycogenolysis by E‐series prostaglandins (1984) (45)
Prostaglandins as mediators of paraneoplastic syndromes: review and up-date. (1981) (45)
Pancreas Transplantation in Humans With Diabetes Mellitus (1991) (45)
Oxygenation products of arachidonic acid: third messengers for insulin release. (1984) (45)
G-Proteins and Hormonal Inhibition of Insulin Secretion From HIT-T15 Cells and Isolated Rat Islets (1992) (44)
High levels of the circulating form of parathyroid hormone do not inhibit in vitro erythropoiesis. (1983) (44)
No Effect of Deferoxamine Therapy on Glucose Homeostasis and Insulin Secretion in Individuals With NIDDM and Elevated Serum Ferritin (1993) (43)
Intrahepatic Glucose Flux as a Mechanism for Defective Intrahepatic Islet α-Cell Response to Hypoglycemia (2008) (43)
Selective deficiency of 1,25-dihydroxycholecalciferol. A cause of isolated skeletal resistance to parathyroid hormone. (1977) (42)
Inhibition of interleukin-1beta-induced COX-2 and EP3 gene expression by sodium salicylate enhances pancreatic islet beta-cell function. (2002) (42)
Effects of prostaglandin synthesis inhibitors on human insulin secretion and carbohydrates tolerance. (1979) (42)
Down-regulation in vivo of PGE receptors and adenylate cyclase stimulation. (1980) (41)
Differential in vivo pulmonary degradation of prostaglandins E1, B1, and A1. (1975) (40)
Prostaglandin E(2) mediates inhibition of insulin secretion by interleukin-1beta. (1999) (39)
Intravenous Glucose Tolerance and Pancreatic Islet β-Cell Function in Patients With Multiple Sclerosis During 2-yr Treatment With Cyclosporin (1989) (39)
Regulation of Human Insulin Gene Transcription by Glucose, Epinephrine, and Somatostatin (1994) (39)
Standardized Mixed-Meal Tolerance and Arginine Stimulation Tests Provide Reproducible and Complementary Measures of β-Cell Function: Results From the Foundation for the National Institutes of Health Biomarkers Consortium Investigative Series (2016) (38)
Reconstitution of glucotoxic HIT-T15 cells with somatostatin transcription factor-1 partially restores insulin promoter activity. (1998) (38)
Prostaglandins, glucose homeostasis, and diabetes mellitus. (1983) (37)
Prevention of Oxidative Stress by Adenoviral Overexpression of Glutathione‐Related Enzymes in Pancreatic Islets (2005) (37)
Islet Transplantation for Type 1 Diabetes, 2015: What Have We Learned From Alloislet and Autoislet Successes? (2015) (36)
Glutathione peroxidase protein expression and activity in human islets isolated for transplantation (2007) (36)
Kinetics of prostaglandin E metabolism in isolated hepatocytes. (1984) (35)
Down-regulation of prostaglandin E receptors and homologous desensitization of isolated adipocytes. (1983) (34)
Hypothesis: PGE, Carbohydrate Homeostasis, and Insulin Secretion: A Suggested Resolution of the Controversy (1983) (34)
Hypoglycemia after pancreas transplantation. (1998) (32)
Arginine is preferred to glucagon for stimulation testing of β-cell function. (2014) (32)
Differentiation between glucose-induced desensitization of insulin secretion and beta-cell exhaustion in the HIT-T15 cell line. (1998) (32)
A role for zinc in pancreatic islet β‐cell cross‐talk with the α‐cell during hypoglycaemia (2011) (31)
Cyclooxygenase-2, Not Microsomal Prostaglandin E Synthase-1, Is the Mechanism for Interleukin-1β-induced Prostaglandin E2 Production and Inhibition of Insulin Secretion in Pancreatic Islets* (2012) (31)
Transfection with SV40 gene of human pancreatic endocrine cells. (1991) (30)
Separate receptors for prostacyclin and prostaglandin E2 on human gel-filtered platelets. (1986) (30)
Rotation of the anatomic regions used for insulin injections and day-to-day variability of plasma glucose in type I diabetic subjects (1990) (30)
Applications and limitations of measurement of 15-keto,13,14-dihydro prostaglandin E2 in human blood by radioimmunoassay. (1979) (30)
Antagonist: diabetes and insulin resistance--philosophy, science, and the multiplier hypothesis. (1995) (30)
Nrf2/antioxidant pathway mediates β cell self-repair after damage by high-fat diet-induced oxidative stress. (2017) (30)
The B55α-containing PP2A holoenzyme dephosphorylates FOXO1 in islet β-cells under oxidative stress. (2012) (30)
Ectopic secretion of chorionic gonadotropin by a lung carcinoma. Pituitary gonadotropin and subunit secretion and prolonged chemotherapeutic remission. (1978) (29)
Early Alterations in Glycemic Control and Pancreatic Endocrine Function in Nondiabetic Patients With Chronic Pancreatitis (2016) (29)
Somatostatin and epinephrine decrease insulin messenger ribonucleic acid in HIT cells through a pertussis toxin-sensitive mechanism. (1991) (28)
Gene expression of type I phospholipase A2 in pancreatic beta cells (1991) (26)
Plasma catecholamine responses to intravenous glucose in normal man. (1974) (25)
Effects of nonsteroidal antiinflammatory drugs in conventional dosage on glucose homeostasis in patients with diabetes. (1983) (25)
An integrated view of beta-cell dysfunction in type-II diabetes. (1996) (24)
Glucose Homeostasis and Insulin Secretion in Human Recipients of Pancreas Transplantation (1989) (23)
A role for endogenous prostaglandins in defective glucose potentiation of nonglucose insulin secretagogues in diabetics. (1981) (23)
Modulation of insulin secretion by cyclic AMP and prostaglandin E: the effects of theophylline, sodium salicylate and tolbutamide. (1982) (23)
Reversal of defective glucagon responses to hypoglycemia in insulin-dependent autoimmune diabetic BB rats. (2007) (23)
Pancreatic islet transplantation for diabetes: successes, limitations, and challenges for the future. (2001) (23)
Pancreatectomy and Autologous Islet Transplantation for Painful Chronic Pancreatitis: Indications and Outcomes (2012) (22)
G-protein regulation of insulin secretion. (1994) (22)
Up-regulation of hepatic prostaglandin E receptors in vivo induced by prostaglandin synthesis inhibitors. (1981) (21)
Glucagon, catecholamine, and symptom responses to hypoglycemia in living donors of pancreas segments. (2003) (21)
Pancreas and islet transplantation. Challenges for the twenty-first century. (1997) (21)
Diabetic ketoacidosis and hyperosmolar nonketotic state. (1996) (21)
Therapeutic controversy: Pancreas transplantation for type I diabetes. (1998) (21)
Prostaglandin synthesis inhibitors reverse alpha-adrenergic inhibition of acute insulin response to glucose. (1980) (21)
Sodium salicylate potentiates neurohumoral responses to insulin-induced hypoglycemia. (1980) (21)
Hypercalcemia induced by prostaglandin E2 in thyroparathyroidectomized but not intact rats. (1977) (20)
Rotation of the anatomic regions used for insulin injections and day-to-day variability of plasma glucose in type I diabetic subjects. (1991) (20)
Update on transplanting beta cells for reversing type 1 diabetes. (2010) (20)
Intrahepatically transplanted islets--strangers in a strange land. (2002) (19)
Seminars in medicine of the Beth Israel Hospital, Boston: Pancreatic and islet transplantation for diabetes--cures or curiosities? (1992) (19)
Paradoxical hypoinsulinaemia: an alpha-adrenergic-mediated response to glucose. (1972) (19)
Pancreas transplantation as therapy for diabetes mellitus. (1992) (19)
Molecular regulation of prostaglandin synthesis Implications for endocrine systems (1995) (18)
Stress-induced inhibition of triglyceride secretion in vivo sand rats (Psammomys obesus). (1976) (18)
Pancreas Transplantation for Type 1 Diabetes— A Summation (1998) (18)
Somatostatin coordinately regulates glucagon gene expression and exocytosis in HIT-T15 cells. (1995) (17)
Effects of systemic delivery of insulin on plasma lipids and lipoprotein concentrations in pancreas transplant recipients. (1994) (17)
Erratum: Reduction of insulin gene transcription in HIT-T15 β cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expression (Cell (September 26, 1995) 92:20 (9127-9131)) (1995) (17)
Prostaglandin E2 Metabolite Levels During Diabetic Ketoacidosis (1985) (17)
Glucose, Insulin, and Glucagon Levels During Exercise in Pancreas Transplant Recipients (1995) (17)
Defective insulin secretion in niddm: Integral part of a multiplier hypothesis (1992) (17)
The COX-2/PGE2/EP3/Gi/o/cAMP/GSIS Pathway in the Islet: The Beat Goes On (2017) (15)
Improve islet yields and quality when clinical grade pancreata are preserved by the two-layer method (2006) (15)
Pancreas and islet transplants for patients with diabetes: taking positions and making decisions. (1999) (15)
Red Wine and Diabetes Health: Getting Skin in the Game (2013) (15)
Molecular basis for prostaglandin potency. III. Tests of the significance of the "hairpin conformation" in biorecognition phenomena. (1981) (14)
Reversal by methysergide of inhibition of insulin secretion by prostaglandin E in the dog. (1978) (14)
Pancreas transplantation for type I diabetes (1998) (14)
Interrelationships between PGE1 and PGI2 binding and stimulation of adenylate cyclase. (1983) (14)
Modulation of insulin secretion in normal and diabetic humans by prostaglandin E and sodium salicylate. (1977) (13)
AIRarg and AIRgluc as predictors of insulin secretory reserve. (2004) (13)
Islet transplantation: Travels up the learning curve (2002) (12)
Prevention of recurrent hypoglycemia in type 1 diabetes by pancreas transplantation (1999) (12)
Reevaluation of the sand rat as a model for diabetes mellitus. (1980) (12)
Secretion and degradation of glucagon by HIT cells. (1990) (12)
Deficient Glucagon Response to Hypoglycemia During a Mixed Meal in Total Pancreatectomy/Islet Autotransplantation Recipients (2018) (12)
Pancreas and islet transplantation in humans. (1996) (12)
The demise of islet allotransplantation in the United States: A call for an urgent regulatory update (2021) (11)
Assessment of b-Cell Mass and a- and b-Cell Survival and Function by Arginine Stimulation in Human (2015) (11)
Hypothesis: prostaglandins mediate defective glucose recognition in diabetes mellitus. (1980) (11)
Effects of tacrolimus ( FK 506 ) on human insulin gene expression , insulin mRNA levels , and insulin secretion in HITT 15 cells (2013) (11)
Preventive effects of octreotide (SMS 201-995) on diabetic ketogenesis during insulin withdrawal. (1991) (11)
Improvement of defective insulin responses to glucose, arginine, and beta-adrenergic stimulation in diabetics by sodium salicylate. (1980) (10)
Evidence for lipoxygenase mediation of arachidonic acid-stimulated insulin secretion. (1983) (10)
In vivo insulin secretion: prostaglandin and adrenergic interrelationships. (1974) (10)
Glucose Homeostasis and Insulin Secretion During Chronic Treatment With Cyclosporin in Nondiabetic Humans (1989) (10)
Diabetes: Strategies to prevent the type 2 diabetes mellitus epidemic (2010) (10)
The Demise of Islet Allotransplantation in the US: A Call for an Urgent Regulatory Update The "ISLETS FOR US" Collaborative. (2020) (10)
Silymarin Activates c-AMP Phosphodiesterase and Stimulates Insulin Secretion in a Glucose-Dependent Manner in HIT-T15 Cells (2016) (9)
[Oxidative stress, insulin secretion, and insulin resistance]. (2001) (9)
Transplanted intrahepatic islets: enigmatic absence of the alpha-cell response to hypoglycaemia. (2002) (8)
Prostaglandins and hypercalcemia of cancer. (1981) (8)
Characterization of Prostaglandin E2 Binding to Isolated Human Adipocytes (1985) (8)
Effect of human fetal pancreas transplantation on secretion of C-peptide and glucose tolerance in type I diabetics. (1987) (7)
Time-related, cross-sectional and prospective follow-up of pancreatic endocrine function after pancreas allograft transplantation in Type 1 (insulin-dependent) diabetic patients (1991) (7)
Arachidonic acid metabolism, the endocrine pancreas, and diabetes mellitus. (1984) (7)
Improvement of insulin secretion in diabetics by a prostaglandin synthesis inhibitor. (1979) (7)
Functional effects of transgenic expression of cholera toxin in pancreatic beta-cells (1993) (7)
Total pancreatectomy and islet autotransplantation for chronic pancreatitis: breaking down barriers. (2015) (7)
Adipocyte Cellularity in the Desert Sand Rat (Psammomys obesus) 1 (1974) (6)
Mixed Meal and Intravenous L-Arginine Tests Both Stimulate Incretin Release Across Glucose Tolerance in Man: Lack of Correlation with β Cell Function. (2018) (6)
A METABOLIC CONSEQUENCE OF OBESITY (1973) (6)
Endocrine Function and Metabolic Outcomes in Pancreas and Islet Transplantation (2004) (6)
The Welcome Resurgence of the α-Cell: A Pro Glucagon Commentary (2010) (5)
Diabetic ketoacidosis and hyperosmolar nonketotic state: gaining control over extreme hyperglycemic complications. (1996) (5)
Iron and diabetes: an attractive hypothesis, but... (1994) (5)
PGE binding in isolated hepatocytes: regulation during fasting. (1987) (5)
Translational Endocrinology & Metabolism: Osteoporosis Update (2010) (5)
A role for prostaglandins as mediators of alpha-adrenergic inhibition of the acute insulin response to glucose. (1980) (5)
EFFECT OF SODIUM SALICYLATE ON HORMONAL RESPONSES TO HYPOGLYCAEMIA IN TYPE II DIABETICS (1984) (4)
Translational Endocrinology & Metabolism: Metabolic Surgery Update (2012) (4)
History of Diabetes, the Journal (1952-1991) editor's swan song. (1992) (4)
2005 update: impact of pancreas and islet transplants on acute and chronic complications of diabetes (2005) (4)
Spontaneous Hypoglycemia After Islet Transplantation: The Case For Using Non-Hepatic Sites. (2016) (4)
Glucose Toxicity and the Insulin Gene (1994) (4)
8 – Interrelationships between Prostaglandins and Biogenic Amines during Modulation of Beta-Cell Function (1981) (4)
Glucose Toxicity , Lipotoxicity , and Chronic Oxidative Stress in Type 2 Diabetes (2003) (4)
Pancreas and Islet Transplantation (1995) (3)
Molecular Regulation of Pancreatic Islet Prostaglandin Synthesis and Its Relevance to Diabetes Mellitus (2004) (3)
Inactivation of speci c β cell transcription factors in type 2 diabetes (2017) (3)
Estimation of β-cell mass by metabolic tests: Necessary, but how sufficient? (Diabetes (2007) 56, (2420-2424)) (2011) (3)
Mechanism of canine cyclic hematopoiesis: The role of prostaglandin E in feedback regulation (1983) (3)
Islet transplantation 2003: questions about its future (2003) (3)
Sounding board. Prostaglandins, the glucoreceptor, and diabetes. (1979) (3)
Sodium salicylate improves defective acute insulin responses to arginine and isoproterenol in diabetics (1979) (3)
Recent Advances in Nutritional Sciences Regulation of the Insulin Gene by Glucose and Fatty Acids 1 (2006) (3)
Experience with pancreas transplants from living related donors (1991) (3)
Variable regulation by insulin of insulin gene expression in HIT-T15 cells (1994) (3)
Sodium salicylate partially reverses alpha adrenergic inhibition of insulin release (1979) (3)
ADA Research Funding in 2009: Where Will We Be? (2009) (3)
Effects of prostaglandin B1 on basal and stimulated circulating levels of insulin, glucose and free fatty acids. (1974) (2)
Islets Transplantation at a Crossroads - Need for Urgent Regulatory Update in the United States: Perspective Presented During the Scientific Sessions 2021 at the American Diabetes Association Congress (2022) (2)
Metabolic Sequelae of Pancreas Transplantation (1989) (2)
Outpatient versus inpatient mixed meal tolerance and arginine stimulation testing yields comparable measures of variability for assessment of beta cell function (2018) (2)
A role for prostaglandin E (PGE) in the hypercalcemia of human cancer (1975) (2)
Perspectives on the New Year (1988) (2)
Diabetes Type 2 (Non-Insulin-Dependent Diabetes Mellitus) (2003) (2)
Nrf 2 / antioxidant pathway mediates β cell self-repair after damage by high-fat diet – induced oxidative stress (2017) (2)
Reversal of prostaglandin (PG) induced inhibition of insulin secretion by methysergide (1977) (2)
Prevention of glucose toxicity in HIT-T15 cells and ZDF rats by an antioxidant, N-acetyl-L-cysteine (1996) (2)
Prevention of hyperglycemia and glucotoxic effects on insulin gene expression by troglitazone in ZDF rats (1996) (1)
Translational Endocrinology & Metabolism: Posterior Pituitary Update (2012) (1)
1987 year book of endocrinology. (1981) (1)
General Practitioner Responsibility in Gynaecology* (1957) (1)
Treatment of diabetes mellitus (1992) (1)
KATP channel mediates the zinc switch-off signal for glucagon response during glucose deprivation (2009) (1)
Novel Nonimmunological Forms of {beta}-Cell Dysfunction: Diabetic Syndromes and Pathogenic Mechanisms. (2008) (1)
2009 Presidential Address: Mentoring … Touching the Future (2009) (1)
Glucose Toxicity of the Pancreatic ß-Cell (2001) (1)
Pancreas Transplantation at the University of Minnesota: 1966–2005 (2006) (1)
Arguments against the Requirement of a Biological License Application for Human Pancreatic Islets: The Position Statement of the Islets for US Collaborative Presented during the FDA Advisory Committee Meeting (2021) (1)
Nrf2 and Antioxidant Response in Animal Models of Type 2 Diabetes (2023) (1)
Sodium salicylate augments glucose recognition and insulin secretion and inhibits prostaglandin synthesis in pancreatic mono layer cultures (1980) (1)
Research funding and ageism. (2015) (1)
Prediction and prevention of type 2 diabetes mellitus (2009) (1)
Medical education without physician scientists: answers without questions. (2000) (1)
Suppression of plasma catecholamines (PCA) and central flushing in man by clonidine (CLON) (1977) (1)
[Hyperinsulinemia as a consequence of systemic venous drainage in patients with pancreas transplantation]. (1991) (1)
Pancreatic Islet Cell Transplantation (2012) (1)
Successful pregnancy after pancreatic islet autotransplantation. (1994) (1)
Prostaglandin receptor: induction of density changes in rat liver plasma membrane. (1980) (1)
Abnormal alpha-adrenergic mechanisms in diabetes mellitus. (1973) (1)
2009 Presidential Address: Mentoring … Touching the Future (2009) (1)
Puzzling About Partial Glucagon Responses to Hypoglycemia in Intrahepatic Islet Recipients: Missing Pieces (2015) (1)
HEPATITIS AFTER INOCULATIONS (1960) (0)
Epistaxis (1958) (0)
Points from letters: Age incidence of gall stones (1976) (0)
WEAR AND TEAR (1950) (0)
Plastic Bags (1959) (0)
CARE OF THE AGED (1953) (0)
Obstetric Emergency Service (1947) (0)
BURNS AND SCALDS (1956) (0)
Through the Storm (2006) (0)
Future directions for condensed matter physics (1999) (0)
JCEM Editor's Swan Song: 2015-2019. (2019) (0)
Dried Plasma for Domiciliary Midwifery (1949) (0)
Treatment of Coughs (1955) (0)
Points: Postnatal depression—does no one care? (1980) (0)
Continuing the JCEM mission with its new editorial team. (2015) (0)
Editorial: Update on stem cell research. (2009) (0)
History of Diabetes, the Journal (1952–1991): Editor's Swan Song (1992) (0)
Prostaglandins as Modulators of Pancreatic Islet Function (1979) (0)
Paradoxical inhibition of insulin (IRI) secretion by glucose (GLU) in human diabetes (1978) (0)
Radioimmunoassay for 13,14-dihydro,15-keto-prostaglandin E2 in human plasma: applications and artifacts. (1980) (0)
Efficacy of adding insulin therapy to sulfonylurea treatment immediately versus later in the course of progressive β-cell failure in type 2 diabetes (2002) (0)
Differential receptor dysfunction in human diabetes (1976) (0)
Endogenous regulators of insulin secretion: interrelationships among prostaglandin (PGE), serotonin (SER) and adrenergic receptors (1976) (0)
The alpha adrenergic receptor: its role in abnormal insulin secretion in diabetes mellitus (1974) (0)
Beta-Cell Replacement: Pancreas and Islet Transplantation (2007) (0)
Evolution of Nrf2 Gene Expression in HIT-T15 β-Cells During Chronic Oxidative Stress and Glucose Toxicity (2022) (0)
Regulation of the prostaglandin E receptor and the guanyl nucleotide regulatory subunit of hepatic adenylate cyclase. (1983) (0)
Factors Predicting Outcomes After a Total Pancreatectomy and s Learned From Over 500 Cases Islet Autotransplantation Lesson (2015) (0)
52. Pancreas and islet transplantation (2015) (0)
Methysergide reversal of prostaglandin E1 inhibition of pancreatic beta cell function (1977) (0)
Dysregulated Release and Degradation of Insulin During Mononuclear Cell–Induced β-Cell Lysis in HIT Cells (1991) (0)
164 GLYCERALDEHYDE INCREASES INTRACELLULAR PEROXIDE LEVELS AND INHIBITS GLUCOSE STIMULATED INSULIN SECRETION. (2004) (0)
Book ReviewPractical Applications of Prostaglandins and Their Synthesis Inhibitors (Advances in prostaglandin research) (1980) (0)
The battered β-cell: usual suspects and guilt by association. (2011) (0)
Diabetes Type 2 (Noninsulin-Dependent Diabetes Mellitus) (2016) (0)
A role for endogenous alpha adrenergic activity in abnormal insulin secretion in diabetics (1975) (0)
Insulin Injections: Rotation of Anatomic Regions and Plasma Glucose-Reply (1990) (0)
Perspective: Inexorable beta cell deterioration via oxidative stress as a secondary complication of Type 2 Diabetes (2021) (0)
Consensus Reports (2011) (0)
State of the Journal: The First 1000 Manuscripts (1989) (0)
Partial remission of diabetes mellitus (type 1 or type 2) (2020) (0)
Accelerated triglyceride secretion in sand rats: a metabolic consequence of sucrose feeding (1979) (0)
ADA Research Funding in 2009: Where Will We Be? (2009) (0)
Reconstitution of glucotoxic HIT-T15 cells with STF-1 partially restores insulin promoter activity (1997) (0)
Translational Endocrinology & Metabolism: Hypoglycemia in Diabetes Update (2012) (0)
1988. The year book of endocrinology. (1988) (0)
Arachidonic acid and metabolic diseases. (1983) (0)
161 THE UNDERLYING MECHANISM OF THE LOSS OF GLUCAGON SECRETION DURING HYPOGLYCEMIA IN DIABETES: THE “SWITCH-OFF HYPOTHESIS.” (2004) (0)
Complete remission of diabetes mellitus (type 1 or type 2) (2020) (0)
Translational Endocrinology & Metabolism: Vitamin D Update (2011) (0)
Paul Eston Lacy, MD, PhD (2005) (0)
Translational Endocrinology & Metabolism: Breast Cancer Update (2012) (0)
Characterization and regulation of the prostaglandin E (PGE) receptor in adipocytes (1982) (0)
Adipocyte prostaglandin E (PGE) receptors mediate counterregulation of lipolysis by PGE2 (1982) (0)
Evidence for regulation of the guanyl nucleotide subunits of adenylate cyclase by prostaglandin (1982) (0)
Insulin-secretin cell lines : classification, characteristics and potential applications (1996) (0)
Sodium salicylate reverses defective glucose potentiation of arginine induced insulin secretion in diabetes (1980) (0)
Remission of diabetes mellitus (type 1 or type 2) (2020) (0)
Down-regulation of prostaglandin E receptors and lipolysis in rat adipocytes. (1983) (0)
What is Successful Islet Transplantation in 2006 (2006) (0)
Lung tumor with ectopic secretion of chorionic gonadotropin (HCG): prolonged chemotherapeutic remission (1977) (0)
Response to Comment on: Robertson (2010) Islet Transplantation a Decade Later and Strategies for Filling a Half-Full Glass. Diabetes;59:1285–1291 (2010) (0)
AIRg and AIRa as surrogate measures for insulin secretory reserve in successful pancreas transplant recipients.: 039 (2003) (0)
460 RESTORATION OF DEFECTIVE GLUCAGON SECRETION DURING HYPOGLYCEMIA IN AUTOIMMUNE DIABETES. (2006) (0)
Isolated skeletal resistance to parathyroid hormone (PTH): correction with 1,25 dihydroxycholecalciferol (DHCC) therapy (1977) (0)
Prostaglandin: increased production by renal cell carcinoma. (1977) (0)
162 SWITCH-OFF HYPOTHESIS: AN EXPLANATION FOR THE DEFECTIVE GLUCAGON RESPONSE TO HYPOGLYCEMIA IN TYPE 1 DIABETES. (2004) (0)
Translational Endocrinology & Metabolism: Type 2 Diabetes Update (2011) (0)
RESTORED INSULIN SECRETION AND EUGLYCEMIA IN TYPE 1 DIABETES A DECADE AND MORE AFTER SUCCESSFUL PANCREAS TRANSPLANTATION. (1999) (0)
Metabolic outcomes after total pancreatectomy followed by islet autotransplantation (TPIAT): Mixed blessings (2020) (0)
Metabolic Measures of Islet Function and Mass After Islet Transplantation (2007) (0)
G-protein and drug trafficking on islet crossroads: implications for stress and diabetes. (1993) (0)
Translational Endocrinology & Metabolism: Neoplasia Update (2011) (0)
Defective insulin responses to adrenergic and glycemic stimuli in insulinoma (1977) (0)
Prostaglandins, glucose homeostasis, and diabetes mellitus. (1981) (0)
Metabolic Sequelae of Pancreas Transplantation (1989) (0)
Translational Endocrinology & Metabolism: Aging Update (2011) (0)
Glucose toxicity and paradoxical decrease in insulin gene transcription in β-TC6 cells (1996) (0)
Pancreas and islet transplantation in the management of diabetes (2003) (0)
G.P. Responsibility in Gynaecology (1957) (0)
MIDWIFE AND/OR DOCTOR (1949) (0)
Précis for JCEM: No Empty Promises. (2016) (0)
SHAKESPEARE AND MEDICINE (1959) (0)
Medical Education Without Physician Scientists: Answers Without Questions (44484) (2000) (0)
Prostaglandins (PG) E1, B1 and A1: Assessment of their hormonal potential by in vivo pulmonary degradation studies (1974) (0)
Trichlorethylene in Labour (1953) (0)
Editorial: ENDO Abstracts and Endocrine Reviews (2010) (0)
Circumcision (1952) (0)
POINTS FROM LETTERS: Interleaved Cotton-wool (1957) (0)
Star wars in medicine: good and bad fallout. (1985) (0)
Commentaries on perspectives in diabetes (2015) (0)
Introduction: a new section, an old hope. (1983) (0)
Points: Measles and Indians (1983) (0)

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