Robert T. Schimke
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(Suggest an Edit or Addition)Robert T. Schimke's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells. (1978) (805)
- Adaptive characteristics of urea cycle enzymes in the rat. (1962) (611)
- Control of enzyme levels in animal tissues. (1970) (548)
- Gene amplification in cultured animal cells (1984) (540)
- THE ROLES OF SYNTHESIS AND DEGRADATION IN THE CONTROL OF RAT LIVER TRYPTOPHAN PYRROLASE. (1965) (443)
- Studies on the synthesis and degradation of proteins of the endoplasmic reticulum of rat liver. (1969) (396)
- Multiple hexokinases of rat tissues. Purification and comparison of soluble forms. (1966) (388)
- Micro assay for 3-hydroxy-3-methylglutaryl-CoA reductase in rat liver and in L-cell fibroblasts. (1974) (353)
- Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes. (1979) (321)
- Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase (1978) (317)
- Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line. (1978) (308)
- Gene amplification, drug resistance, and cancer. (1984) (300)
- THE IMPORTANCE OF BOTH SYNTHESIS AND DEGRADATION IN THE CONTROL OF ARGINASE LEVELS IN RAT LIVER. (1964) (289)
- Gene amplification and drug resistance in cultured murine cells. (1978) (275)
- Multiple forms of hexokinase in the rat: tissue distribution, age dependency, and properties. (1965) (267)
- Influence of turnover rates on the responses of enzymes to cortisone. (1965) (265)
- Transient hypoxia enhances the frequency of dihydrofolate reductase gene amplification in Chinese hamster ovary cells. (1986) (250)
- Gene amplification in cultured cells. (1988) (249)
- Cell line-specific differences in the control of cell cycle progression in the absence of mitosis. (1990) (243)
- Synthesis of double-stranded DNA complementary to lysozyme, ovomucoid, and ovalbumin mRNAs. Optimization for full length second strand synthesis by Escherichia coli DNA polymerase I. (1978) (236)
- Studies on factors affecting the levels of urea cycle enzymes in rat liver. (1963) (224)
- Transcription factor Sp1 recognizes a DNA sequence in the mouse dihydrofolate reductase promoter (1986) (221)
- INTERACTION OF ESTROGEN AND PROGESTERONE IN CHICK OVIDUCT DEVELOPMENT (1969) (220)
- 2-5A synthetase: assay, distribution and variation with growth or hormone status (1979) (212)
- Identification and isolation of ovalbumin-synthesizing polysomes. I. Specific binding of 125 I-anti-ovalbumin to polysomes. (1972) (205)
- Differential effects of fasting and protein-free diets on levels of urea cycle enzymes in rat liver. (1962) (204)
- Defining cellular senescence in IMR-90 cells: a flow cytometric analysis. (1988) (203)
- Unstable DNA amplifications in methotrexate resistant Leishmania consist of extrachromosomal circles which relocalize during stabilization (1984) (202)
- Overreplication and recombination of DNA in higher eukaryotes: potential consequences and biological implications. (1986) (199)
- INTERACTION OF ESTROGEN AND PROGESTERONE IN CHICK OVIDUCT DEVELOPMENT (1969) (199)
- Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica. (1983) (196)
- Synthesis of full length cDNAs from four partially purified oviduct mRNAs. (1978) (195)
- Properties of an altered dihydrofolate reductase encoded by amplified genes in cultured mouse fibroblasts. (1981) (187)
- Modulation of ovalbumin synthesis by estradiol-17 beta and actinomycin D as studied in explants of chick oviduct in culture. (1971) (185)
- Size heterogeneity in the 3′ end of dihydrofolate reductase messenger RNAs in mouse cells (1980) (182)
- Enhancement of methotrexate resistance and dihydrofolate reductase gene amplification by treatment of mouse 3T6 cells with hydroxyurea (1983) (179)
- Quantitative measurement of ovalbumin messenger ribonucleic acid activity. Localization in polysomes, induction by estrogen, and effect of actinomycin D. (1973) (172)
- CHAPTER 32 – Regulation of Protein Degradation in Mammalian Tissues12 (1970) (162)
- ENZYMES OF ARGININE METABOLISM IN MAMMALIAN CELL CULTURE. I. REPRESSION OF ARGININOSUCCINATE SYNTHETASE AND ARGININOSUCCINASE. (1964) (161)
- BCL-2 expression delays drug-induced apoptosis but does not increase clonogenic survival after drug treatment in HeLa cells. (1995) (160)
- Gene amplification in a single cell cycle in Chinese hamster ovary cells. (1984) (159)
- Cytotoxic effects of cell cycle phase specific agents: result of cell cycle perturbation. (1990) (154)
- Studies on the attachment of carbohydrate to ovalbumin nascent chains in hen oviduct. (1976) (151)
- Peptide transport by the multidrug resistance pump. (1992) (149)
- Size distribution of membrane proteins of rat liver and their relative rates of degradation. (1971) (149)
- Correlation of dihydrofolate reductase elevation with gene amplification in a homogeneously staining chromosomal region in L5178Y cells (1979) (141)
- Gene amplification in a leukemic patient treated with methotrexate. (1984) (141)
- Structure and genomic organization of the mouse dihydrofolate reductase gene (1980) (137)
- An analysis of the kinetics of rat liver tryptophan pyrrolase induction: the significance of both enzyme synthesis and degradation. (1964) (133)
- The generation of energy by the arginine dihydrolase pathway in Mycoplasma hominis 07. (1966) (131)
- Synthesis and degradation of folate reductase in sensitive and methotrexate-resistant lines of S-180 cells. (1976) (128)
- Cytologic evidence for gene amplification in methotrexate-resistant cells obtained from a patient with ovarian adenocarcinoma. (1984) (127)
- UV radiation facilitates methotrexate resistance and amplification of the dihydrofolate reductase gene in cultured 3T6 mouse cells (1984) (126)
- Amplification and loss of dihydrofolate reductase genes in a Chinese hamster ovary cell line (1981) (125)
- Heterogeneity of genetic loci in chickens: analysis of endogenous viral and nonviral genes by cleavage of DNA with restriction endonucleases (1979) (124)
- Studies of the stability in vivo and in vitro of rat liver tryptophan pyrrolase. (1965) (122)
- Preparation of electrocompetent E. coli using salt-free growth medium. (1996) (122)
- Studies on the correlation between size and relative degradation rate of soluble proteins. (1973) (120)
- Isolation of hen oviduct ovalbumin and rat live albumin polysomes by indirect immunoprecipitation. (1974) (114)
- Control of enzyme levels in mammalian tissues. (2006) (113)
- Indolent Staphylococcus albus or aureus bacteremia after ventriculoatriostomy. Role of foreign body in its initiation and perpetuation. (1961) (112)
- Transcriptional regulation of mouse dihydrofolate reductase in the cell cycle. (1985) (111)
- Methylmercury hydroxide enhancement of translation and transcription of ovalbumin and conalbumin mRNA's. (1979) (111)
- Quantitation of dihydrofolate reductase in individual parental and methotrexate-resistant murine cells. Use of a fluorescence activated cell sorter. (1978) (107)
- Structure of amplified normal and variant dihydrofolate reductase genes in mouse sarcoma S180 cells. (1982) (107)
- Independent genetic control of the catalytic activity and the rate of degradation of catalase in mice. (1969) (106)
- Synthesis of a deoxyribonucleic acid sequence complementary to ovalbumin messenger ribonucleic acid and quantification of ovalbumin genes. (1973) (102)
- Relationship of amplified dihydrofolate reductase genes to double minute chromosomes in unstably resistant mouse fibroblast cell lines (1981) (102)
- P-glycoprotein confers methotrexate resistance in 3T6 cells with deficient carrier-mediated methotrexate uptake. (1996) (102)
- Synthesis of ovalbumin in a rabbit reticulocyte cell-free system programmed with hen oviduct ribonucleic acid. (1971) (101)
- Protein degradation in human fibroblasts (WI-38). Effects of aging, viral transformation, and amino acid analogs. (1976) (101)
- Turnover and exchange of ribosomal proteins from rat liver. (1972) (100)
- Induction of ovalbumin mRNA sequences by estrogen and progesterone in chick oviduct as measured by hybridization to complementary DNA. (1975) (99)
- Regulation of protein synthesis in chick oviduct. 3. Mechanism of ovalbumin "superinduction" by actinomycin D. (1973) (98)
- In vivo inhibition of cyclin B degradation and induction of cell-cycle arrest in mammalian cells by the neutral cysteine protease inhibitor N-acetylleucylleucylnorleucinal. (1993) (96)
- On the Roles of Synthesis and Degradation in Regulation of Enzyme Levels in Mammalian Tissues (1969) (95)
- Dissociation of nuclear and cytoplasmic cell cycle progression by drugs employed in cell synchronization. (1995) (95)
- Tetracycline-controlled gene expression system achieves high-level and quantitative control of gene expression. (1996) (94)
- Cell cycle analysis of apoptosis using flow cytometry. (1995) (94)
- Rapid spontaneous dihydrofolate reductase gene amplification shown by fluorescence-activated cell sorting. (1983) (93)
- ARGININE METABOLISM IN PLEUROPNEUMONIA-LIKE ORGANISMS ISOLATED FROM MAMMALIAN CELL CULTURE (1963) (93)
- A Rapid Chemical Method for Detecting PPLO Contamination of Tissue Cell Cultures (1963) (91)
- Chromosomal and extrachromosomal localization of amplified dihydrofolate reductase genes in cultured mammalian cells. (1981) (90)
- Frequencies of independent and simultaneous selection of Chinese hamster cells for methotrexate and doxorubicin (adriamycin) resistance. (1987) (89)
- Nucleotide sequence surrounding multiple polyadenylation sites in the mouse dihydrofolate reductase gene. (1982) (88)
- Presence of the Arginine Dihydrolase Pathway in Mycoplasma (1966) (87)
- The Genetic and Developmental Regulation of Hepatic δ-Aminolevulinate Dehydratase in Mice (1969) (86)
- Unstable amplification of an altered dihydrofolate reductase gene associated with double-minute chromosomes (1981) (86)
- Heterogeneity at the 5' termini of mouse dihydrofolate reductase mRNAs. Evidence for multiple promoter regions. (1985) (85)
- Synthesis of rat liver albumin in a rabbit reticulocyte cell-free protein-synthesizing system. (1973) (85)
- Expression of abbreviated mouse dihydrofolate reductase genes in cultured hamster cells. (1982) (85)
- Amplification of dihydrofolate reductase genes in methotrexate-resistant cultured mouse cells. (1978) (83)
- Quantitative Studies of White Matter II. Enzymes involved in triose phosphate metabolism (1961) (81)
- Methotrexate resistance and gene amplification. Mechanisms and implications (1986) (78)
- Identification of methotrexate transport deficiency in mammalian cells using fluoresceinated methotrexate and flow cytometry. (1987) (77)
- Ovalbumin messenger RNA: evidence that the initial product of transcription is the same size as polysomal ovalbumin messenger. (1974) (76)
- Loss and stabilization of amplified dihydrofolate reductase genes in mouse sarcoma S-180 cell lines (1981) (75)
- Immunochemical isolation and characterization of ovalbumin messenger ribonucleic acid. (1975) (73)
- Opposite-strand RNAs from the 5' flanking region of the mouse dihydrofolate reductase gene. (1985) (72)
- S phase-specific synthesis of dihydrofolate reductase in Chinese hamster ovary cells. (1981) (69)
- Identification and isolation of ovalbumin-synthesizing polysomes. II. Quantification and immunoprecipitation of polysomes. (1972) (68)
- Induction of apoptosis by the anti-tubulin drug colcemid: relationship of mitotic checkpoint control to the induction of apoptosis in HeLa S3 cells. (1994) (68)
- Ultrastructural features of minute chromosomes in a methotrexate-resistant mouse 3T3 cell line. (1985) (67)
- Differences in the regulation of protein synthesis, cyclin B accumulation, and cellular growth in response to the inhibition of DNA synthesis in Chinese hamster ovary and HeLa S3 cells. (1993) (67)
- Regulation of folate reductase synthesis in sensitive and methotrexate-resistant sarcoma 180 cells. In vitro translation and characterization of folate reductase mRNA. (1976) (64)
- Hormonal regulation of ovalbumin synthesis in chick oviduct. (1973) (64)
- Methods for analysis of enzyme synthesis and degradation in animal tissues. (1975) (64)
- Purification of ovalbumin messenger ribonucleic acid by specific immunoadsorption of ovalbumin-synthesizing polysomes and millipore partition of ribonucleic acid. (1973) (62)
- Effect of size on the relative rate of degradation of rat liver soluble proteins. (1970) (62)
- Cyclin B1 expression in HeLa S3 cells studied by flow cytometry. (1994) (62)
- Effects of phenobarbital, 3-methylcholanthrene, and hematin on the synthesis of protein components of rat liver microsomal membranes. (1972) (62)
- Differences in mitotic control among mammalian cells. (1991) (61)
- Novel DNA rearrangements are associated with dihydrofolate reductase gene amplification. (1984) (61)
- Increased gene amplification in L5178Y mouse lymphoma cells with hydroxyurea-induced chromosomal aberrations. (1985) (59)
- Regulation of protein turnover in mammalian tissues. (1968) (59)
- Gene localization by chromosome fractionation: globin genes are on at least two chromosomes and three estrogen-inducible genes are on three chromosomes. (1979) (59)
- Gene amplification and drug resistance. (1980) (58)
- Thermal denaturation of DNA for immunochemical staining of incorporated bromodeoxyuridine (BrdUrd): critical factors that affect the amount of fluorescence and the shape of BrdUrd/DNA histogram. (1989) (57)
- Polyoma virus and cyclic AMP-mediated control of dihydrofolate reductase mRNA abundance in methotrexate-resistant mouse fibroblasts. (1979) (56)
- Biological Regulation and Development (1980) (53)
- STUDIES ON ISOZYMES OF HEXOKINASE IN ANIMAL TISSUES * (1968) (53)
- The structural gene for α mannosidase 1 in Dictyostelium discoideum (1976) (50)
- [37] Arginase (rat liver) (1970) (48)
- Electrophoretic properties and tissue distribution of multiple forms of hexokinase in various mammalian species. (1966) (48)
- Protein alterations in aging WI38 cells as determined by proteolytic susceptibility. (1975) (47)
- Cellular detoxification of tripeptidyl aldehydes by an aldo-keto reductase. (1993) (47)
- Congenital hyperammonemia. Association with hyperglycinemia and decreased levels of carbamyl phosphate synthetase. (1970) (47)
- Post-transcriptional regulation in higher eukaryotes: The role of the reporter gene in controlling expression (1991) (46)
- Turnover of Membrane Proteins in Animal Cells (1975) (44)
- Murine dihydrofolate reductase transcripts through the cell cycle (1986) (43)
- Sequential amplification of dihydrofolate reductase and multidrug resistance genes in Chinese hamster ovary cells selected for stepwise resistance to the lipid-soluble antifolate trimetrexate. (1989) (43)
- Arginine breakdown in mammalian cell culture contaminated with pleuropneumonia-like organisms (PPLO). (1963) (42)
- Functional analysis of the tobacco mosaic virus tRNA-like structure in cytoplasmic gene regulation. (1991) (42)
- In vitro transcription and delimitation of promoter elements of the murine dihydrofolate reductase gene (1986) (41)
- Over-replication of DNA in S phase Chinese hamster ovary cells after DNA synthesis inhibition. (1987) (41)
- Cross-resistance to the lipid-soluble antifolate trimetrexate in human carcinoma cells with the multidrug-resistant phenotype. (1989) (39)
- Construction of bacterial plasmids that contain the nucleotide sequence for bovine corticotropin-beta-lipotropin precursor. (1978) (39)
- Specific binding of albumin antibody to rat liver polysomes. (1974) (38)
- Regulation of translation of ovalbumin messenger RNA by estrogens and progesterone in oviduct of withdrawn chicks. (1978) (38)
- A re-examination of the 5' termini of mouse dihydrofolate reductase RNA. (1986) (37)
- Progesterone Antagonism of Estrogen-Induced Cytodifferentiation in Chick Oviduct (1969) (36)
- Life, death and genomic change in perturbed cell cycles. (1994) (36)
- Characterization and genetic mapping of modA. A mutation in the post-translational modification of the glycosidases of Dictyostelium discoideum. (1978) (36)
- On the activities of some enzymes concerned with glycolysis and glycogenolysis in extracts of rabbit skeletal muscles. (1968) (36)
- [64] Assay of ovalbumin mRNA in reticulocyte lysate (1974) (35)
- Enhancement of the frequency of methotrexate resistance by gamma-radiation in Chinese hamster ovary and mouse 3T6 cells. (1989) (35)
- Transient inhibition of DNA synthesis results in increased dihydrofolate reductase synthesis and subsequent increased DNA content per cell (1986) (35)
- Improvements in immunoprecipitation of specific messenger RNA. Isolation of highly purified conalbumin mRNA in high yield. (1979) (35)
- Repression of enzymes of arginine biosynthesis in mammalian tissue culture. (1962) (35)
- The activities of some enzymes concerned with energy metabolism in mammalian muscles of differing pigmentation. (1969) (35)
- Mechanisms of 3-hydroxy-3-methylglutaryl coenzyme A reductase overaccumulation in three compactin-resistant cell lines. (1985) (34)
- The pattern of dihydrofolate reductase expression through the cell cycle in rodent and human cultured cells. (1989) (34)
- Studies of a mutation affecting pyrimidine degradation in inbred mice. (1970) (34)
- Rapid emergence of methotrexate resistance in cultured mouse cells. (1984) (33)
- Turnover of chromosomal proteins from rat liver. (1973) (31)
- Gene amplification; what are we learning? (1992) (30)
- Effects of prolonged light deprivation on the development of retinal enzymes in the rabbit. (1959) (30)
- Effect of cycloheximide on development of methotrexate resistance of Chinese hamster ovary cells treated with inhibitors of DNA synthesis (1988) (30)
- Differential effects of estrogen and progesterone on ovalbumin mRNA utilization. (1978) (28)
- Improvements in the Epstein-Barr-based shuttle vector system for direct cloning in human tissue culture cells (1992) (27)
- Studies on the amplification of dihydrofolate reductase genes in methotrexate-resistant cultured mouse cells. (1979) (27)
- Fifth Gordon Hamilton-Fairley memorial lecture. Methotrexate resistance and gene amplification: an experimental model for the generation of cellular heterogeneity. (1985) (25)
- cDNA expression cloning in human cells using the pλDR2 episomal vector system (1992) (24)
- The propensity for gene amplification: a comparison of protocols, cell lines, and selection agents. (1994) (23)
- Catalase turnover in human diploid cell cultures. (1972) (23)
- Effects of a post-translational modification mutation on different developmentally regulated glycosidases in Dictyostelium discoideum. (1978) (23)
- CHAPTER 8 – Nucleic Acid Probes and Analysis of Hormone Action in Oviduct (1975) (23)
- Expression of the mouse serum albumin gene introduced into differentiated and dedifferentiated rat hepatoma cells. (1985) (23)
- Construction and analysis of DNA sequence libraries from flow-sorted chromosomes: practical and theoretical considerations. (1984) (22)
- Immunoadsorption of ovalbumin synthesizing polysosmes and partial purification of ovalbumin messenger RNA. (1974) (22)
- Effects of secobarbital and of d-amphetamine on psychomotor performance of normal subjects. (1960) (21)
- A cell cycle analysis of growth-related genes expressed during T lymphocyte maturation (1990) (21)
- A study of chromosomal changes associated with amplified dihydrofolate reductase genes in rat hepatoma cells and their dedifferentiated variants (1984) (21)
- Intracellular protein turnover (1975) (20)
- STUDIES ON THE METABOLISM OF ARGININE BY MYCOPLASMA (1967) (20)
- A phenotype conferring selective resistance to lipophilic antifolates in Chinese hamster ovary cells. (1991) (20)
- Partial purification of the ovalbumin gene (1976) (19)
- Characterization by flow cytometry of fluorescein-methotrexate transport in Chinese hamster ovary cells. (1989) (18)
- Organization of polysomes from pre-existing ribosomes in chick oviduct by a secondary administration of either estradiol or progesterone. (1970) (18)
- Perturbation of DNA replication and cell cycle progression by commonly used [3H]thymidine labeling protocols (1990) (18)
- Human cDNA clones that modify radiomimetic sensitivity of ataxia-telangiectasia (group A) cells (1995) (17)
- [7] Amplification of genes in somatic mammalian cells (1987) (17)
- A rapid procedure for isolation of RNA-free genomic DNA from mammalian cells. (1993) (17)
- Purification and properties of an exo-β-d-1,3-glucanase from sea urchin eggs (1969) (17)
- Characterization of the coexisting multiple mechanisms of methotrexate resistance in mouse 3T6 R50 fibroblasts. (1992) (17)
- Initiation of protein synthesis in bacteria at a translational start codon of mamalian cDNA: effects of the preceding nucleotide sequence. (1980) (16)
- Inhibition of apoptosis by overexpressing Bcl-2 enhances gene amplification by a mechanism independent of aphidicolin pretreatment. (1996) (16)
- The search for early genetic events in tumorigenesis: an amplification paradigm. (1990) (16)
- Studies on adaptation of urea cycle enzymes in the rat. (1961) (15)
- Temporal order of DNA replication in the H-2 major histocompatibility complex of the mouse (1992) (14)
- The synthesis and degradation of membrane proteins. (1973) (14)
- Cell cycle regulation of transfected murine dihydrofolate reductase genes. (1986) (14)
- Identification and isolation of ovalbumin-synthesizing polysomes. 3. Precipitation of ovalbumin polysomes from a heterologous cell-free protein-synthesizing system. (1973) (12)
- Interaction of hyperthermia and metabolic inhibitors on the induction of chromosome damage in Chinese hamster ovary cells. (1987) (11)
- Flow cytometric characterization of antifolate resistance in cultured mammalian cells using fluoresceinated methotrexate and daunorubicin. (1990) (11)
- Induction of Apoptosis by Cell-Cycle Phase Specific Drugs (1994) (11)
- Heterogeneity in the mitotic checkpoint control of BALB/3T3 cells and a correlation with gene amplification propensity. (1994) (11)
- Gene amplification and drug resistance in cultured animal cells. (1984) (11)
- Gene amplification and drug resistance in mammalian cells. (1982) (11)
- Isolation of recombinant plasmids bearing cDNA to hen ovomucoid and lysozyme mRNAs. (1979) (9)
- Toxicity of folic acid analogs in cultured human cells: a microtiter assay for the analysis of drug competition. (1987) (9)
- Amplification of genes in somatic mammalian cells. (1987) (9)
- Fifth annual Pezcoller symposium: apoptosis. (1994) (9)
- Restriction map of the region surrounding the EcoRI site in the pCR1 plasmid and analysis of an inserted ovalbumin gene. (1979) (9)
- Flow cytometric analysis of mammalian glial cultures treated with methotrexate (1990) (9)
- [38] Micromethods for the assay of argininosuccinate synthetase, argininosuccinase, and arginase☆☆☆★ (1970) (9)
- Chimeric 3-hydroxy-3-methylglutaryl coenzyme A reductase-dihydrofolate reductase genes display bidirectional expression and unidirectional regulation in stably transfected cells (1989) (9)
- A family of repeated DNA sequences, one of which resides in the second intervening sequence of the mouse dihydrofolate reductase gene. (1983) (8)
- Ovalbumin mRNA, complementary DNA and hormone regulation in chick oviduct. (1973) (8)
- Hormonal regulation of ovalbumin synthesis in the chick oviduct. (1975) (8)
- The genetic and developmental regulation of hepatic delta-aminolevulinate dehydratase in mice. (1969) (7)
- Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells. 1978. (1992) (7)
- Bromodeoxyuridine/DNA analysis of replication in CHO cells after exposure to UV light. (1993) (7)
- Principles underlying the regulation of synthesis and degradation of proteins in animal tissues (1974) (7)
- The localization of glyceraldehyde 3-phosphate dehydrogenase in kidney tissue by means of fluorescent antibody (1963) (6)
- Assay of ovalbumin mRNA in reticulocyte lysate. (1974) (6)
- [51] l-tryptophan 2,3-dioxygenase (tryptophan pyrrolase) (rat liver)☆ (1970) (6)
- Murine catalase phenotypes (1970) (6)
- pλZd39: a new type of cDNA expression vector for low background, high efficiency directional cloning (1991) (6)
- Biological Regulation and Development (1979) (5)
- Reduced-stringency DNA reassociation: sequence specific duplex formation. (1982) (5)
- Gene Amplification , Drug Resistance , and Cancer 1 (2006) (5)
- Intronic positioning maximizes co-expression and co-amplification of nonselectable heterologous genes. (1989) (5)
- Protein turnover and the control of enzyme levels in animal tissues (1970) (5)
- Rapid distribution of research materials: Whose responsibility is it? (1988) (5)
- Protein turnover and the regulation of enzyme levels in rat liver. (1967) (5)
- The synthesis and degradation of membrane proteins. (1974) (5)
- Symposium on Hormonal Control of Protein Biosynthesis. (1967) (4)
- Specificity of the binding of antibodies to polysomes in hen oviduct. (1974) (4)
- INDUCTION, STABILIZATION AND TURNOVER OF ENDOPLASMIC RETICULUM PROTEINS* (1969) (4)
- Gene amplification and methotrexate resistance in cultured animal cells. (1980) (4)
- 3 – On the Mechanism of Induced Gene Amplification in Mammalian Cells (1988) (4)
- ENZYMES OF ARGININE METABOLISM IN CELL CULTURE: STUDIES ON ENZYME INDUCTION AND REPRESSION. (1964) (4)
- On the frequency of metaphase chromosome aberrations in the small intestine of aged rats. (1990) (4)
- Complementation of the Cellular A-T Phenotype by Gene Transfer. (1993) (4)
- Detection of anti-tumor immunity in man by the indirect macrophage adherence inhibition assay using guinea pig peritoneal cells as indicator cells. (1981) (3)
- Comparison of the haemocytometer and tube modifications of the leucocyte adherence inhibition assay. (1981) (3)
- Structure and Localization of Dihydrofolate Reductase Genes in Methotrexate-Resistant Cultured Cells (1979) (3)
- Apoptosis. Fifth Pezcoller Foundation Symposium--Trento, Italy, June 9-11, 1993. (1994) (3)
- Flow-cytometric analysis of spermatogenesis in Teleogryllus commodus (1989) (3)
- Biologic Mechanisms in Aging (1983) (3)
- Gene Amplification in Cultured Animal Cells Review (1984) (3)
- Studies on the roles of synthesis and degradation in the control of enzyme levels in animal tissues. (1966) (3)
- Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase. 1978. (1992) (3)
- Intragenomic DNA sequence homologies in the chicken and other members of the classAves: DNA re-association under reduced stringency conditions (1980) (3)
- Protein Degradation in Vivo and Its Regulation (1976) (3)
- Two RFLPs for the human dihydrofolate reductase gene (DHFR). (1987) (2)
- A fluorescein-methotrexate-based flow cytometric bioassay for measurement of plasma methotrexate and trimetrexate levels. (1989) (2)
- EFFECTS OF ESTROGEN AND PROGESTERONE ON OVALBUMIN SYNTHESIS IN THE WITHDRAWN OVIDUCT * (1977) (2)
- The discovery of gene amplification in mammalian cells: to be in the right place at the right time. (1989) (2)
- MEASUREMENT OF PROTEIN SYNTHESIS AND TURNOVER IN ANIMAL CELLS WITH TRITIATED WATER**This work was supported in part by Grant No. CA-13038 of the National Cancer Institute, National Institutes of Health. (1978) (2)
- THE ROLE OF DOUBLE MINUTE CHROMOSOMES IN UNSTABLE METHOTREXATE RESISTANCE (1981) (2)
- Comparison of the hemocytometer and tube modifications of the leukocyte adherence inhibition assay -- II. Application of both modifications for detection of anti-tumor immunity in man. (1981) (2)
- [33] Ornithine carbamyltransferase (Mycoplasma) (1970) (2)
- Overreplication of DNA and the rapid generation of genomic change. (1986) (2)
- Purification and properties of an exo-beta-D-1,3-glucanase from sea urchin eggs. (1969) (1)
- [36] Arginine deiminase (Mycoplasma)☆ (1970) (1)
- Estrogen Regulation of Ovalbumin mRNA Content and Utilization1 (1973) (1)
- Methotrexate Resistance, Gene Amplification, and Somatic Cell Heterogeneity (1985) (1)
- Deletion of stably integrated DNA is suppressed by cadmium and zinc. (1989) (1)
- The structural gene for alpha-mannosidase-1 in Dictyostellium discoideum. (1976) (1)
- LossandStabilization ofAmplified Dihydrofolate Reductase GenesinMouseSarcoma S-180 CellLines (1981) (1)
- Initiation of protein synthesis in bacteria at a translational start codon of mammalian cDNA : Effects of the preceding nucleotide sequence ( genetic expression / dihydrofolate reductase / plasmid / DNA cloning / ribosome binding ) (1)
- Hormones in Development. Papers from a conference, Nottingham, England, Sept. 1968. Max Hamburgh and E. J. W. Barrington, Eds. Appleton-Century-Crofts, New York, 1971. xx, 854 pp., illus. $30 (1972) (0)
- CYCLIN B DEGRADATION AS A TARGET OF ANTIPROLIFERATIVE DRUG ACTION (1994) (0)
- 3 Heat-induced chromosome damage in cho K1 cells is altered by treatment with metabolic inhibitors (1987) (0)
- Induction of dihydrofolate reductase synthesis by polyoma virus in methotrexate. resistant 3T6 cells (1978) (0)
- Letter from Robert T. Schimke to Merton Bernfield (1978) (0)
- [Ascitic fluid as an additional source of antibody production]. (1973) (0)
- BCL-2 Expression Delays Drug-induced Apoptosis but Does Not Increase Clonogenic Survival after Drug Treatment in HeLa Cells1 (2006) (0)
- Induction of dihydrofolate reductase synthesis by polyoma virus in methotrexate-resistant mouse fibroblasts (1978) (0)
- [Contributions to the orthology of the lateral geniculate body of the rat]. (1968) (0)
- Amplification of dihydrofolate reductase (dhfr) genes in an l5178y line resistant to methotrexate (mtx). Abstr. (1979) (0)
- [Flexible-chain 6-mercaptopurine-protein conjugates. 18. Immunosuppressive-antigen conjugates]. (1977) (0)
- Book Review:Enzyme Synthesis and Degradation in Mammalian Systems. Miloslav Rechcigl (1972) (0)
- The project-grant application of the National Institutes of Health. Preparation of the project-grant applications: assistance from the grantee institution's experienced investigators. (1973) (0)
- Synthesis of RNA from cellulose-bound complementary DNA. (1977) (0)
- 2 Mechanisms of gene amplification (1987) (0)
- Dihydrofolate Reductase Gene Amplification, Altered Dihydrofolate Reductase, and Methotrexate Resistance in Cultured 3T6 Cells Associated with Unstable Amplification of an Altered Dihydrofolate Reductase Gene (1982) (0)
- [6-mercaptopurine-protein conjugates prepared by reductive alkylation. 15. Immunosuppressive antigen conjugates]. (1977) (0)
- [The macrophage disappearance reaction in guinea pigs sensitized with bovine gamma globulin or human scrum albumin (author's transl)]. (1977) (0)
- p lambda Zd39: a new type of cDNA expression vector for low background, high efficiency directional cloning. (1991) (0)
- [Detection of cell-mediated immunity against protein antigen by the macrophage adherence inhibition test (author's transl)]. (1978) (0)
- (methotrexate selection/DNA transfection/in vitro DNA recombinatioi (2016) (0)
- Developmental Processes: Hormones in Development . Papers from a conference, Nottingham, England, Sept. 1968. Max Hamburgh and E. J. W. Barrington, Eds. Appleton-Century-Crofts, New York, 1971. xx, 854 pp., illus. $30. (1972) (0)
- Nutrition Classics. The Journal of Biological chemistry, 39:3808-17, 1964. The importance of both synthesis and degradation in the control of arginase levels in rat liver. Robert T. Schimke. (1979) (0)
- Macromolecular Metabolism. Jerard Hurwitz (1967) (0)
- The acquisition of methotrexate resistance by gene amplification (1984) (0)
- A method for the preparation of metaphase chromosomes from rat small intestine. (1988) (0)
- Strand specific DNA repair in different stages of the cell cycle (1993) (0)
- Macrophage adherence inhibition assay: measurements of adherent cells by the TV image analysis system Densitron. (1981) (0)
- Ovalbumin mRNA and ovalbumin DNA and the molecular biology of steroid hormone action. (1975) (0)
- Regulation of enzyme levels in animal tissues: the role of enzyme degradation. (1973) (0)
- Amplification andLossofDihydrofolate Reductase Genesina Chinese Hamster OvaryCellLine (1981) (0)
- Quantitative Studies of White Matter (1964) (0)
- Small Molecules and Great Things (1971) (0)
- Properties of an Altered Dihydrofolate Reductase Amplified Genes in Cultured Mouse Fibroblasts* Encoded by (1981) (0)
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