Rafael De Cabo
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Rafael De Cabomathematics Degrees
Mathematics
#8323
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#11312
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Measure Theory
#3730
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#4397
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Rafael De Cabobiology Degrees
Biology
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#19520
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Molecular Biology
#2683
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#2724
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Biochemistry
#2722
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#2907
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Mathematics Biology
Rafael De Cabo's Degrees
- PhD Biochemistry University of Granada
Why Is Rafael De Cabo Influential?
(Suggest an Edit or Addition)Rafael De Cabo's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Resveratrol improves health and survival of mice on a high-calorie diet (2006) (4154)
- Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging (2013) (1074)
- Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study (2012) (1005)
- Nutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell Survival (2007) (752)
- Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2 (2010) (466)
- Are sirtuins viable targets for improving healthspan and lifespan? (2012) (348)
- Mitochondrial biogenesis and healthy aging (2008) (324)
- The Search for Antiaging Interventions: From Elixirs to Fasting Regimens (2014) (293)
- Of mice and men: The benefits of caloric restriction, exercise, and mimetics (2012) (264)
- Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: Role of circulating factors and SIRT1 (2009) (219)
- Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile (2013) (213)
- Reduced Expression of MYC Increases Longevity and Enhances Healthspan (2015) (213)
- Development of Calorie Restriction Mimetics as a Prolongevity Strategy (2004) (200)
- Resveratrol supplementation: Where are we now and where should we go? (2015) (193)
- Age‐associated vascular oxidative stress, Nrf2 dysfunction and NF‐κB activation in the non‐human primate Macaca mulatta (2011) (180)
- MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels (2015) (172)
- Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress (2007) (171)
- The impact of low-protein high-carbohydrate diets on aging and lifespan (2016) (160)
- Adaptive induction of NF‐E2–Related Factor‐2‐driven antioxidant genes in endothelial cells in response to hyperglycemia (2011) (147)
- The plasma membrane redox system in aging (2006) (147)
- Calorie restriction attenuates age-related alterations in the plasma membrane antioxidant system in rat liver (2004) (144)
- NRF2, cancer and calorie restriction (2011) (119)
- Disruption of Nrf2 signaling impairs angiogenic capacity of endothelial cells: implications for microvascular aging (2012) (119)
- An in vitro model of caloric restriction (2003) (111)
- The effect of resveratrol on lifespan depends on both gender and dietary nutrient composition in Drosophila melanogaster (2013) (97)
- Calorie restriction in rodents: Caveats to consider (2017) (86)
- Dietary activators of Sirt1 (2009) (85)
- LKB1 and AMPK regulate synaptic remodeling in old age (2014) (83)
- Nutritional strategies to optimise cognitive function in the aging brain (2016) (80)
- Hungry for life: How the arcuate nucleus and neuropeptide Y may play a critical role in mediating the benefits of calorie restriction (2009) (75)
- The potential for dietary restriction to increase longevity in humans: extrapolation from monkey studies (2006) (74)
- Adipogenic signaling in rat white adipose tissue: Modulation by aging and calorie restriction (2007) (73)
- Up‐regulation of plasma membrane‐associated redox activities in neuronal cells lacking functional mitochondria (2007) (71)
- Carbotoxicity—Noxious Effects of Carbohydrates (2018) (66)
- Manipulation of caloric content but not diet composition, attenuates the deficit in learning and memory of senescence-accelerated mouse strain P8 (2008) (62)
- Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice (2016) (61)
- Branched chain amino acids, aging and age-related health (2020) (61)
- Calorie restriction, aging and longevity (2010) (57)
- Comparative approaches to facilitate the discovery of prolongevity interventions: Effects of tocopherols on lifespan of three invertebrate species (2007) (57)
- Effect of calorie restriction and refeeding on skin wound healing in the rat (2012) (55)
- Bioenergetics of aging and calorie restriction (2006) (53)
- The human longevity gene homolog INDY and interleukin‐6 interact in hepatic lipid metabolism (2017) (47)
- Caloric restriction reduces age-related pseudocapillarization of the hepatic sinusoid (2007) (42)
- The plasma membrane redox system is impaired by amyloid β-peptide and in the hippocampus and cerebral cortex of 3xTgAD mice (2010) (40)
- Toll-like receptors 2 and 4 modulate autonomic control of heart rate and energy metabolism (2014) (40)
- Mouse liver plasma membrane redox system activity is altered by aging and modulated by calorie restriction (2005) (37)
- Frailty index as a biomarker of lifespan and healthspan: Focus on pharmacological interventions (2019) (36)
- Acetaminophen hepatotoxicity in mice: Effect of age, frailty and exposure type (2016) (36)
- Neuroprotection provided by dietary restriction in rats is further enhanced by reducing glucocortocoids (2012) (35)
- Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging : role of circulating factors and SIRT 1 (2009) (32)
- Effect of caloric restriction on base-excision repair (BER) in the aging rat brain (2010) (31)
- Mitochondrial ultrastructure and markers of dynamics in hepatocytes from aged, calorie restricted mice fed with different dietary fats (2014) (31)
- Comparison of rat liver and brain proteasomes for oxidative stress-induced inactivation: Influence of ageing and dietary restriction (2009) (29)
- Translational strategies in aging and age-related disease (2015) (27)
- Preserved learning and memory following 5-fluorouracil and cyclophosphamide treatment in rats (2011) (27)
- Alterations in liver sinusoidal endothelium in a baboon model of type 1 diabetes (2007) (25)
- Dietary fat modifies mitochondrial and plasma membrane apoptotic signaling in skeletal muscle of calorie-restricted mice (2013) (24)
- The plasma membrane redox enzyme NQO1 sustains cellular energetics and protects human neuroblastoma cells against metabolic and proteotoxic stress (2012) (24)
- Calorie restriction alters physical performance but not cognition in two models of altered neuroendocrine signaling (2008) (23)
- Adaptations to oxidative stress induced by vitamin E deficiency in rat liver (2006) (23)
- Caloric Restriction Modulates Early Events in Insulin Signaling in Liver and Skeletal Muscle of Rat (2004) (23)
- Age-associated learning and memory deficits in two mouse versions of the stone T-maze (2012) (19)
- Effects of aging and calorie restriction on rat skeletal muscle glycogen synthase and glycogen phosphorylase (2009) (19)
- The influence of dietary fat source on liver and skeletal muscle mitochondrial modifications and lifespan changes in calorie-restricted mice (2015) (19)
- The effect of ageing on isoniazid pharmacokinetics and hepatotoxicity in Fischer 344 rats (2016) (19)
- Influence of anaerobic and aerobic exercise on age-related pathways in skeletal muscle (2017) (17)
- Effects of Intermittent Fasting on Health, Aging, and Disease. (2020) (16)
- The Roy Walford legacy: diet restriction from molecules to mice to monkeys to man and onto mimetics (2004) (16)
- Erratum: Osteocalcin Signaling in Myofibers Is Necessary and Sufficient for Optimum Adaptation to Exercise (Cell Metabolism (2016) 23(6) (1078–1092)(S1550413116302224)(10.1016/j.cmet.2016.05.004)) (2017) (16)
- A High Fat Diet and NAD+ Rescue Premature Aging in Cockayne Syndrome (2014) (12)
- The impact of aging, calorie restriction and dietary fat on mitochondrial ultrastructure, dynamics and autophagy markers in mouse skeletal muscle (2019) (11)
- Nutrition and aging (2010) (9)
- N‐Acetyl cysteine does not prevent liver toxicity from chronic low‐dose plus subacute high‐dose paracetamol exposure in young or old mice (2016) (9)
- Discoidin domain Receptor 2: A determinant of metabolic syndrome-associated arterial fibrosis in non-human primates (2019) (9)
- Dietary Activators of Sirt 1 (2009) (8)
- The effect of aging on mitochondrial and cytosolic hepatic intrinsic death pathway and apoptosis associated proteins in Fischer 344 rats (2015) (8)
- Calorie Restriction in Nonhuman Primates: Impact on Aging, Disease, and Frailty (2005) (8)
- Mitochondrial adaptations in liver and skeletal muscle to pro-longevity nutritional and genetic interventions: the crosstalk between calorie restriction and CYB5R3 overexpression in transgenic mice (2020) (6)
- The Aging Liver and the Effects of Long Term Caloric Restriction (2010) (6)
- Calorie Restriction and Aging (2010) (6)
- Preclinical frailty assessments: Phenotype and frailty index identify frailty in different mice and are variably affected by chronic medications (2022) (4)
- Will Calorie Restriction Stave Off Age-Related Brain Dysfunction, Specifically to Learning and Memory? A Review and Critique of the Rodent Literature (2010) (3)
- - Aguirre Reduction in Pro-Aging Signaling , Cancer , and Diabetes in Humans Growth Hormone Receptor Deficiency Is Associated with a Major (2011) (3)
- Small Molecule Modulators of Sirtuin Activity (2010) (3)
- collagen remodeling of tissue in a mouse model of emphysema: possible role Mechanics, nonlinearity, and failure strength of lung (2015) (2)
- History of the Study of Calorie Restriction in Nonhuman Primates Conducted by the National Institute on Aging: The First Decade (2015) (2)
- Caloric restriction and cardiovascular disease (2010) (2)
- Abstract 1717: Calorie Restriction Reduces MMP-2 Activity and Retards Age-associated Aortic Restructuring in Rats (2006) (2)
- Selected Abstracts from the American Aging Association 47th Annual Meeting “Improving Resilience to Delay Aging” Philadelphia, 2018 (2018) (1)
- Skeletal Aging: From Bench to Bed Side (2013) (1)
- Vasoprotective effects of caloric restriction in aging (2010) (1)
- Fasting-Mimicking Diet Re duces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity Graphical (1)
- A LOW PROTEIN, HIGH CARBOHYDRATE DIET ATTENUATES BRAIN AGING AND IMPROVES SPATIAL MEMORY IN MICE (2017) (1)
- Involvement of JNK in TNFα driven remodelling (2015) (1)
- Calorie Restriction and Cancer: An Update (2010) (1)
- Hypothalamic involvement in the beneficial effects of restricted diets on glucose tolerance in mice (2007) (0)
- Basic nutritional investigation Caloric restriction modulates insulin receptor signaling in liver and skeletal muscle of rat (2005) (0)
- Dietary restriction and induced tumorigenesis in mice with altered hypothalamic appetite regulation (2008) (0)
- EFFECT OF CHRONIC POLYPHARMACY AND THE DRUG BURDEN INDEX (DBI) ON PHYSICAL FUNCTION IN AGED MICE. (2017) (0)
- Dietary Protein to Carbohy drate Ratio and Caloric Restriction : Comparing Metabolic Outcomes in Mice Graphical Abstract Highlights (2015) (0)
- Response to DR. Mitnitski's anD DR. RockwooD's LetteR to the eDitoR: BioLogicaL age RevisiteD (2013) (0)
- COMPARATIVE PROTEOMIC ANALYSIS OF NORMAL AND NQO 1-NULL MOUSE EMBRYO FIBROBLASTS (2013) (0)
- Abstract B016: Aberrant age-related methylation leads to tumor predisposition in colorectal organoids (2023) (0)
- Impairing the Nrf2-Dependent Antioxidant Response: A Novel Model of Vascular Aging Liver-Specific Knockdown of IGF-1 Decreases Vascular Oxidative Stress Resistance by (2011) (0)
- ReseRv ations in accepting t hat t he R e i s "Depletion of Bone Ma RRo w pRogenit o R c ells w ith aging. " g ene R alization s houl D Be av oi D e D (2012) (0)
- Resveratrol abrogates tumor-evoked Bregs conversion by targeting PPAR-alpha pathway (127.41) (2012) (0)
- Metabolic adaptations and modulation of coenzyme Q system through nutritional interventions and CYB5R3 overexpression in transgenic mice (2018) (0)
- Acknowledgement to referees 2012 (2012) (0)
- Metabolic Flexibility: Interplay of Diet Composition and Intermittent Fasting on Healthspan (P08-053-19) (2019) (0)
- Apoptotic signaling of skeletal muscle tissue in response to cytochrome b5 reductase 3 over-expression and dietary interventions (2018) (0)
- Tumor-Evoked Regulatory B Cells Resveratrol-Mediated Inactivation of Inhibition of Breast Cancer Metastasis by (2013) (0)
- Cell Types to Chemotherapy Fasting Cycles Retard Growth of Tumors and Sensitize a Range of (2012) (0)
- LeakRegulation and Physiology of Mitochondrial Proton (2015) (0)
- Modulation of mitochondrial, autophagic, and nutrient sensing pathways markers in liver and skeletal muscle by overexpression of the redox enzyme NADH-cytochrome b5 reductase-3 in male and female mice (2021) (0)
- of large granular lymphocyte leukemia on blood DNA methylation and epigenetic clock modeling in Fischer 344 rats (2021) (0)
- A TRANSLATIONAL MODEL TO UNDERSTAND THE IMPACT OF POLYPHARMACY ON ADVERSE GERIATRIC OUTCOMES (2017) (0)
- Clinical Report Disulfiram Treatment Normalizes Body Weight in Obese Mice (2020) (0)
- Two-Year Trial of Human Caloric Restriction (2015) (0)
- Pulmonary Hypertension Resveratrol Prevents Monocrotaline-Induced Pulmonary Hypertension in Rats (2009) (0)
- Erratum to: Effect of calorie restriction and refeeding on skin wound healing in rats (2012) (0)
- Contents Vol. 90, 2012 (2012) (0)
- Response to the LetteR "Age A nd site shou L d be conside R ed when investig Ating the effect of g Ro wth fAct o R s on hum A n bone-de R ived ce LL s" (2014) (0)
- NQO1 in aging and disease: Novel roles of a quinone reductase (2016) (0)
- 1 ADCK 2 haploinsufficiency reduces mitochondrial 2 lipid oxidation and causes myopathy associated with 3 CoQ deficiency 4 (2019) (0)
- Abstract P139: Cytochrome B5 Reductase 3 Biases Activation of Soluble Guanylyl Cyclase in Resistance Arteries (2019) (0)
- 1 Negative Regulation of STAT 3-mediated Cellular Respiration by SirT 1 (2011) (0)
- Aging and Dietary Restriction: The Yeast Paradigm (2010) (0)
- Dietary Restriction and Aging in Drosophila Melanogaster (2010) (0)
- Natural infection of human adenovirus 36 in rhesus monkeys is associated with gain in body fat, yet, reduction in fasting glucose (2013) (0)
- Modulation of mitochondrial metabolism markers and mitochondrial morphology by aging and CYB5R3 overexpression in transgenic mice (2021) (0)
- Telomere Biology and Cardiovascular Disease Vascular Cell Senescence: Contribution to Atherosclerosis Stem Cells and the Regeneration of the Aging Cardiovascular System Mechanisms of Cardiovascular Disease in Accelerated Aging Syndromes Mechanisms Underlying Caloric Restriction and Lifespan Regulati (2008) (0)
- Ketones facilitate transcriptional resolution of secondary DNA structures in premature aging (2022) (0)
- Comparative proteomic analysis of normal and NQO1-null mouse embryo fibroblasts (2009) (0)
- HEALTHSPAN IN MICE AS A PRECLINICAL OUTCOME IN OLD AGE (2017) (0)
- AGEING AND DRUG-INDUCED LIVER INJURY: INSIGHTS FROM ANIMAL STUDIES (2017) (0)
- Hormetic response via Nrf2 in mice with a genetic deletion of the antioxidant enzyme NQO1 (2012) (0)
- monocrotaline-induced pulmonary hypertension Role of inhibition of nitric oxide production in (2015) (0)
- I'm not Dead Yet: Flies and Mice (2014) (0)
- Abstract 13797: Effects of Resveratrol Supplementation on Walking Performance in Peripheral Artery Disease: A Randomized Clinical Trial (2016) (0)
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