Rafael Augusto Lopes Franco

Rafael Augusto Lopes Franco's AcademicInfluence.com Rankings

Biology

#10873

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#14233

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Neuroscience

#1727

World Rank

#1781

Historical Rank

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Biology

Rafael Augusto Lopes Franco's Degrees

Bachelors Biology University of São Paulo

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Rafael Augusto Lopes Franco's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Presynaptic Control of Striatal Glutamatergic Neurotransmission by Adenosine A1–A2A Receptor Heteromers (2006) (567)
Coaggregation, Cointernalization, and Codesensitization of Adenosine A2A Receptors and Dopamine D2Receptors* (2002) (506)
Alternatively activated microglia and macrophages in the central nervous system (2015) (501)
Dopamine D1 and adenosine A1 receptors form functionally interacting heteromeric complexes. (2000) (464)
Adenosine A2A-Dopamine D2 Receptor-Receptor Heteromerization (2003) (427)
Building a new conceptual framework for receptor heteromers. (2009) (376)
Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: Implications for striatal neuronal function (2002) (369)
Molecular Mechanisms and Therapeutical Implications of Intramembrane Receptor/Receptor Interactions among Heptahelical Receptors with Examples from the Striatopallidal GABA Neurons (2003) (323)
Detection of heteromerization of more than two proteins by sequential BRET-FRET (2008) (296)
Cell surface adenosine deaminase: Much more than an ectoenzyme (1997) (258)
Receptor heteromerization in adenosine A2A receptor signaling (2003) (254)
Adenosine receptor–dopamine receptor interactions in the basal ganglia and their relevance for brain function (2007) (246)
An update on adenosine A2A-dopamine D2 receptor interactions: implications for the function of G protein-coupled receptors. (2008) (242)
Striatal Adenosine A2A and Cannabinoid CB1 Receptors Form Functional Heteromeric Complexes that Mediate the Motor Effects of Cannabinoids (2007) (240)
Metabotropic glutamate type 5, dopamine D2 and adenosine A2a receptors form higher‐order oligomers in living cells (2009) (239)
CD26, adenosine deaminase, and adenosine receptors mediate costimulatory signals in the immunological synapse. (2005) (238)
Adenosine A2A and dopamine D2 heteromeric receptor complexes and their function (2007) (210)
IFN-gamma up-regulates the A2B adenosine receptor expression in macrophages: a mechanism of macrophage deactivation. (1999) (208)
Cannabinoid Receptors CB1 and CB2 Form Functional Heteromers in Brain* (2012) (204)
Identification of Dopamine D1–D3 Receptor Heteromers (2008) (203)
Phosphodiesterases as therapeutic targets for Alzheimer's disease. (2012) (195)
Combining mass spectrometry and pull-down techniques for the study of receptor heteromerization. Direct epitope-epitope electrostatic interactions between adenosine A2A and dopamine D2 receptors. (2004) (194)
Aspects of the general biology of adenosine A2A signaling (2007) (192)
Mechanisms of cannabidiol neuroprotection in hypoxic–ischemic newborn pigs: Role of 5HT1A and CB2 receptors (2013) (179)
Metabotropic Glutamate 1α and Adenosine A1 Receptors Assemble into Functionally Interacting Complexes* (2001) (179)
Homodimerization of adenosine A2A receptors: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer (2003) (178)
Evidence for Adenosine/Dopamine Receptor Interactions: Indications for Heteromerization (2000) (166)
Antagonistic cannabinoid CB1/dopamine D2 receptor interactions in striatal CB1/D2 heteromers. A combined neurochemical and behavioral analysis (2008) (165)
Direct involvement of σ-1 receptors in the dopamine D1 receptor-mediated effects of cocaine (2010) (161)
Interactions between histamine H3 and dopamine D2 receptors and the implications for striatal function (2008) (160)
Role of glutamate on T-cell mediated immunity (2007) (159)
A1 Adenosine Receptors Accumulate in Neurodegenerative Structures in Alzheimer's Disease and Mediate Both Amyloid Precursor Protein Processing and Tau Phosphorylation and Translocation (2003) (158)
Functional relevance of neurotransmitter receptor heteromers in the central nervous system (2007) (157)
Sildenafil restores cognitive function without affecting β‐amyloid burden in a mouse model of Alzheimer's disease (2011) (156)
Successful therapies for Alzheimer’s disease: why so many in animal models and none in humans? (2014) (152)
Adenosine A2A receptor stimulation potentiates nitric oxide release by activated microglia (2005) (152)
Health Benefits of Methylxanthines in Cacao and Chocolate (2013) (152)
Marked changes in signal transduction upon heteromerization of dopamine D1 and histamine H3 receptors (2009) (152)
Past, present and future of A(2A) adenosine receptor antagonists in the therapy of Parkinson's disease. (2011) (149)
Circadian-Related Heteromerization of Adrenergic and Dopamine D4 Receptors Modulates Melatonin Synthesis and Release in the Pineal Gland (2012) (148)
Adenosine A1-A2A receptor heteromers: new targets for caffeine in the brain. (2008) (145)
Immunological identification of A1 adenosine receptors in brain cortex (1995) (144)
Adenosine A2A-dopamine D2 receptor-receptor heteromers. Targets for neuro-psychiatric disorders. (2004) (142)
Glutamate Released by Dendritic Cells as a Novel Modulator of T Cell Activation1 (2006) (142)
CB2 receptor and amyloid pathology in frontal cortex of Alzheimer's disease patients (2013) (141)
Expression of A2B adenosine receptors in human lymphocytes: their role in T cell activation. (1999) (138)
Striatal Pre- and Postsynaptic Profile of Adenosine A2A Receptor Antagonists (2011) (133)
Cocaine Inhibits Dopamine D2 Receptor Signaling via Sigma-1-D2 Receptor Heteromers (2013) (131)
Group I Metabotropic Glutamate Receptors Mediate a Dual Role of Glutamate in T Cell Activation* (2004) (128)
Adenosine–cannabinoid receptor interactions. Implications for striatal function (2010) (127)
Tadalafil crosses the blood–brain barrier and reverses cognitive dysfunction in a mouse model of AD (2013) (125)
Expression of the mRNA coding the cannabinoid receptor 2 in the pallidal complex of Macaca fascicularis (2011) (124)
Adenosine A2A Receptor and Dopamine D3 Receptor Interactions: Evidence of Functional A2A/D3 Heteromeric Complexes (2005) (123)
The emergence of neurotransmitters as immune modulators. (2007) (122)
Adenosine A2A receptor-antagonist/dopamine D2 receptor-agonist bivalent ligands as pharmacological tools to detect A2A-D2 receptor heteromers. (2009) (122)
Adenosine A2B receptors behave as an alternative anchoring protein for cell surface adenosine deaminase in lymphocytes and cultured cells. (2001) (120)
Adenosine receptor‐mediated modulation of dopamine release in the nucleus accumbens depends on glutamate neurotransmission and N‐methyl‐d‐aspartate receptor stimulation (2004) (120)
Understanding the Functional Plasticity in Neural Networks of the Basal Ganglia in Cocaine Use Disorder: A Role for Allosteric Receptor-Receptor Interactions in A2A-D2 Heteroreceptor Complexes (2016) (120)
Adenosine Deaminase and A1 Adenosine Receptors Internalize Together following Agonist-induced Receptor Desensitization* (1998) (120)
Neurotransmitter receptor heteromers and their integrative role in ‘local modules’: The striatal spine module (2007) (119)
Dopamine D1-histamine H3 Receptor Heteromers Provide a Selective Link to MAPK Signaling in GABAergic Neurons of the Direct Striatal Pathway* (2010) (119)
Binding and Signaling Studies Disclose a Potential Allosteric Site for Cannabidiol in Cannabinoid CB2 Receptors (2017) (119)
Detection of Heteromers Formed by Cannabinoid CB1, Dopamine D2, and Adenosine A2A G-Protein-Coupled Receptors by Combining Bimolecular Fluorescence Complementation and Bioluminescence Energy Transfer (2008) (117)
A1R–A2AR heteromers coupled to Gs and Gi/0 proteins modulate GABA transport into astrocytes (2013) (117)
The relevance of theobromine for the beneficial effects of cocoa consumption (2015) (115)
Intramembrane receptor–receptor interactions: a novel principle in molecular medicine (2006) (113)
Working memory deficits in transgenic rats overexpressing human adenosine A2A receptors in the brain (2007) (113)
Targeting Cannabinoid CB2 Receptors in the Central Nervous System. Medicinal Chemistry Approaches with Focus on Neurodegenerative Disorders (2016) (110)
Interactions between Intracellular Domains as Key Determinants of the Quaternary Structure and Function of Receptor Heteromers* (2010) (108)
Detection of higher‐order G protein‐coupled receptor oligomers by a combined BRET–BiFC technique (2008) (108)
Basic Pharmacological and Structural Evidence for Class A G-Protein-Coupled Receptor Heteromerization (2016) (105)
Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with Gi and Gs (2016) (104)
The Adenosine A2A Receptor Interacts with the Actin-binding Protein α-Actinin* (2003) (104)
Comodulation of CXCR4 and CD26 in Human Lymphocytes* (2001) (102)
Involvement of caveolin in ligand-induced recruitment and internalization of A(1) adenosine receptor and adenosine deaminase in an epithelial cell line. (2001) (101)
Heteromerization of GPR55 and cannabinoid CB2 receptors modulates signalling (2014) (101)
Adenosine Receptor Heteromers and their Integrative Role in Striatal Function (2007) (101)
Immunodensity and mRNA expression of A2A adenosine, D2 dopamine, and CB1 cannabinoid receptors in postmortem frontal cortex of subjects with schizophrenia: effect of antipsychotic treatment (2009) (100)
Involvement of adenosine A2A and dopamine receptors in the locomotor and sensitizing effects of cocaine (2006) (93)
Heterodimeric adenosine receptors: a device to regulate neurotransmitter release (2006) (93)
Looking for the role of cannabinoid receptor heteromers in striatal function (2009) (92)
Ligand-induced phosphorylation, clustering, and desensitization of A1 adenosine receptors. (1997) (92)
Basic Concepts in G-Protein-Coupled Receptor Homo- and Heterodimerization (2007) (89)
Detection of cannabinoid receptors CB1 and CB2 within basal ganglia output neurons in macaques: changes following experimental parkinsonism (2014) (88)
Regulation of heptaspanning-membrane-receptor function by dimerization and clustering. (2003) (87)
Dopamine D4 receptor, but not the ADHD-associated D4.7 variant, forms functional heteromers with the dopamine D2S receptor in the brain (2011) (87)
GPCR homomers and heteromers: a better choice as targets for drug development than GPCR monomers? (2009) (87)
Receptor-heteromer mediated regulation of endocannabinoid signaling in activated microglia. Role of CB1 and CB2 receptors and relevance for Alzheimer’s disease and levodopa-induced dyskinesia (2018) (87)
The Two-State Dimer Receptor Model: A General Model for Receptor Dimers (2006) (86)
l-DOPA-treatment in primates disrupts the expression of A2A adenosine–CB1 cannabinoid–D2 dopamine receptor heteromers in the caudate nucleus (2014) (83)
CB1 and GPR55 receptors are co-expressed and form heteromers in rat and monkey striatum (2014) (80)
Receptor–receptor interactions involving adenosine A1 or dopamine D1 receptors and accessory proteins (2006) (79)
Up‐regulation of the Kv3.4 potassium channel subunit in early stages of Alzheimer's disease (2004) (79)
Adenosine Deaminase Interacts with A1 Adenosine Receptors in Pig Brain Cortical Membranes (1996) (79)
Striatal plasticity at the network level. Focus on adenosine A2A and D2 interactions in models of Parkinson's Disease. (2004) (79)
Mitochondrial angiotensin receptors in dopaminergic neurons. Role in cell protection and aging-related vulnerability to neurodegeneration (2016) (78)
Heteromeric Nicotinic Acetylcholine–Dopamine Autoreceptor Complexes Modulate Striatal Dopamine Release (2007) (76)
l-DOPA disrupts adenosine A2A–cannabinoid CB1–dopamine D2 receptor heteromer cross-talk in the striatum of hemiparkinsonian rats: Biochemical and behavioral studies (2014) (76)
Ligand-induced caveolae-mediated internalization of A1 adenosine receptors: morphological evidence of endosomal sorting and receptor recycling. (2003) (76)
Old and new ways to calculate the affinity of agonists and antagonists interacting with G-protein-coupled monomeric and dimeric receptors: the receptor-dimer cooperativity index. (2007) (76)
Adenosine A2A receptors are expressed in human atrial myocytes and modulate spontaneous sarcoplasmic reticulum calcium release. (2006) (74)
Dimer-based model for heptaspanning membrane receptors. (2005) (74)
Decreased levels of guanosine 3′, 5′‐monophosphate (cGMP) in cerebrospinal fluid (CSF) are associated with cognitive decline and amyloid pathology in Alzheimer's disease (2015) (74)
The monoacylglycerol lipase inhibitor JZL184 is neuroprotective and alters glial cell phenotype in the chronic MPTP mouse model (2014) (73)
Cannabigerol Action at Cannabinoid CB1 and CB2 Receptors and at CB1–CB2 Heteroreceptor Complexes (2018) (73)
Calcium mobilization in Jurkat cells via A2b adenosine receptors (1997) (73)
Role of electrostatic interaction in receptor-receptor heteromerization (2007) (72)
Abnormal calcium handling in atrial fibrillation is linked to up-regulation of adenosine A2A receptors. (2011) (72)
A First-in-Class Small-Molecule that Acts as a Dual Inhibitor of HDAC and PDE5 and that Rescues Hippocampal Synaptic Impairment in Alzheimer’s Disease Mice (2017) (72)
Oligomerization of G-protein-coupled receptors: a reality. (2010) (71)
Health benefits of methylxanthines in neurodegenerative diseases. (2017) (71)
G‐protein‐coupled receptor heteromers: function and ligand pharmacology (2008) (71)
Solubilization of A1 adenosine receptor from pig brain: Characterization and evidence of the role of the cell membrane on the coexistence of high‐ and low‐affinity states (1990) (70)
The Heat Shock Cognate Protein hsc73 Assembles with A1 Adenosine Receptors To Form Functional Modules in the Cell Membrane (2000) (70)
Possible role of intramembrane receptor-receptor interactions in memory and learning via formation of long-lived heteromeric complexes: focus on motor learning in the basal ganglia. (2003) (69)
Adenosine A2A receptor ligand recognition and signaling is blocked by A2B receptors (2018) (68)
Adenosine deaminase binding to human CD26 is inhibited by HIV-1 envelope glycoprotein gp120 and viral particles. (1997) (68)
Use of implicit methods from general sensitivity theory to develop a systematic approach to metabolic control. II. Complex systems. (1989) (67)
Interactions between Calmodulin, Adenosine A2A, and Dopamine D2 Receptors* (2009) (65)
Regulation of epithelial and lymphocyte cell adhesion by adenosine deaminase-CD26 interaction. (2002) (64)
Molecular mechanisms involved in the adenosine A1 and A2A receptor‐induced neuronal differentiation in neuroblastoma cells and striatal primary cultures (2005) (63)
Cannabidiol skews biased agonism at cannabinoid CB1 and CB2 receptors with smaller effect in CB1‐CB2 heteroreceptor complexes (2018) (63)
Structures for G-Protein-Coupled Receptor Tetramers in Complex with G Proteins. (2015) (62)
Cross-communication between Gi and Gs in a G-protein-coupled receptor heterotetramer guided by a receptor C-terminal domain (2018) (62)
Use of implicit methods from general sensitivity theory to develop a systematic approach to metabolic control. I. Unbranched pathways. (1989) (61)
Purinergic signaling in Parkinson's disease. Relevance for treatment (2016) (61)
Enzymatic and extraenzymatic role of adenosine deaminase 1 in T-cell-dendritic cell contacts and in alterations of the immune function. (2007) (61)
Phenylbutyrate is a multifaceted drug that exerts neuroprotective effects and reverses the Alzheimer´s disease-like phenotype of a commonly used mouse model. (2013) (60)
Interactions among adenosine deaminase, adenosine A1 receptors and dopamine D1 receptors in stably cotransfected fibroblast cells and neurons (2002) (59)
Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity. (2020) (59)
Adenosine deaminase potentiates the generation of effector, memory, and regulatory CD4+ T cells (2011) (57)
ATP-Sensitive K+ Channels Regulate the Concentrative Adenosine Transporter CNT2 following Activation by A1 Adenosine Receptors (2004) (56)
GPR55: A therapeutic target for Parkinson's disease? (2017) (55)
Chronic mild stress accelerates the onset and progression of the Alzheimer's disease phenotype in Tg2576 mice. (2012) (55)
Allosteric modulation of dopamine D2 receptors by homocysteine. (2006) (54)
Plasma membrane diffusion of G protein-coupled receptor oligomers. (2008) (54)
Adenosine receptors and Parkinson's disease. Relevance of antagonistic adenosine and dopamine receptor interactions in the striatum. (2001) (53)
Dopamine D2 and angiotensin II type 1 receptors form functional heteromers in rat striatum. (2015) (53)
GPR40 activation leads to CREB and ERK phosphorylation in primary cultures of neurons from the mouse CNS and in human neuroblastoma cells (2014) (53)
Reinforcing and neurochemical effects of cannabinoid CB1 receptor agonists, but not cocaine, are altered by an adenosine A2A receptor antagonist (2011) (53)
Stronger Dopamine D1 Receptor-Mediated Neurotransmission in Dyskinesia (2015) (52)
Human adenosine deaminase as an allosteric modulator of human A1 adenosine receptor: abolishment of negative cooperativity for [3H](R)‐pia binding to the caudate nucleus (2008) (52)
Fatty acid amide hydrolase inhibition for the symptomatic relief of Parkinson’s disease (2016) (52)
Role of adenosine in the control of homosynaptic plasticity in striatal excitatory synapses. (2005) (52)
Dynamic Regulation of CXCR1 and CXCR2 Homo- and Heterodimers1 (2009) (50)
Adenosine A2A Receptors and A2A Receptor Heteromers as Key Players in Striatal Function (2011) (50)
Increased α-Defensins 1-3 Production by Dendritic Cells in HIV-Infected Individuals Is Associated with Slower Disease Progression (2010) (49)
Concomitant histone deacetylase and phosphodiesterase 5 inhibition synergistically prevents the disruption in synaptic plasticity and it reverses cognitive impairment in a mouse model of Alzheimer’s disease (2015) (49)
The cluster-arranged cooperative model: a model that accounts for the kinetics of binding to A1 adenosine receptors. (1996) (49)
CD26 and adenosine deaminase interaction: its role in the fusion between horse membrane vesicles and spermatozoa. (1999) (48)
CCR5/CD4/CXCR4 oligomerization prevents HIV-1 gp120IIIB binding to the cell surface (2014) (48)
New Methods to Evaluate Colocalization of Fluorophores in Immunocytochemical Preparations as Exemplified by a Study on A2A and D2 Receptors in Chinese Hamster Ovary Cells (2005) (48)
G protein-coupled receptor heteromers as new targets for drug development. (2010) (47)
Adenosine A(1) receptor in cultured neurons from rat cerebral cortex: colocalization with adenosine deaminase. (2002) (47)
Neurochemical evidence supporting dopamine D1–D2 receptor heteromers in the striatum of the long-tailed macaque: changes following dopaminergic manipulation (2016) (46)
A2A adenosine receptor ligand binding and signalling is allosterically modulated by adenosine deaminase. (2011) (46)
Useful pharmacological parameters for G-protein-coupled receptor homodimers obtained from competition experiments. Agonist-antagonist binding modulation. (2009) (45)
Adenosine A2A Receptor Antagonists in Neurodegenerative Diseases: Huge Potential and Huge Challenges (2018) (45)
Molecular and functional interaction between GPR18 and cannabinoid CB2 G‐protein‐coupled receptors. Relevance in neurodegenerative diseases (2018) (45)
The Adenosine Receptors Present on the Plasma Membrane of Chromaffin Cells Are of the A2b Subtype (1992) (45)
The adenosine A2A receptor interacts with the actin-binding protein alpha-actinin. (2003) (45)
Dopamine receptor heteromeric complexes and their emerging functions. (2014) (44)
Angiotensin type 2 receptors: Role in aging and neuroinflammation in the substantia nigra (2019) (44)
Light resonance energy transfer-based methods in the study of G protein-coupled receptor oligomerization. (2008) (43)
Antioxidant Defense Mechanisms in Erythrocytes and in the Central Nervous System (2019) (43)
Actin-binding Protein α-Actinin-1 Interacts with the Metabotropic Glutamate Receptor Type 5b and Modulates the Cell Surface Expression and Function of the Receptor* (2007) (43)
Trafficking of adenosine A2A and dopamine D2 receptors (2007) (42)
Pharmacologic antagonism of dopamine receptor D3 attenuates neurodegeneration and motor impairment in a mouse model of Parkinson's disease (2017) (41)
The potential of methylxanthine-based therapies in pediatric respiratory tract diseases. (2016) (41)
Metabotropic glutamate type 1α receptor localizes in low‐density caveolin‐rich plasma membrane fractions (2003) (41)
Alterations in Gene and Protein Expression of Cannabinoid CB2 and GPR55 Receptors in the Dorsolateral Prefrontal Cortex of Suicide Victims (2018) (40)
How calmodulin interacts with the adenosine A(2A) and the dopamine D(2) receptors. (2008) (40)
Pharmacological data of cannabidiol- and cannabigerol-type phytocannabinoids acting on cannabinoid CB1, CB2 and CB1/CB2 heteromer receptors. (2020) (40)
Novel pharmacological targets based on receptor heteromers (2008) (40)
IDENTIFICATION OF DOPAMINE D 1 -D 3 RECEPTOR HETEROMERS: INDICATIONS FOR A ROLE OF SYNERGISTIC D 1 -D 3 RECEPTOR INTERACTIONS IN THE STRIATUM* (2008) (40)
Heteroreceptor Complexes Formed by Dopamine D1, Histamine H3, and N-Methyl-D-Aspartate Glutamate Receptors as Targets to Prevent Neuronal Death in Alzheimer’s Disease (2017) (39)
A model of the pentose phosphate pathway in rat liver cells (1995) (39)
Antioxidants versus Food Antioxidant Additives and Food Preservatives (2019) (39)
Understanding the Role of Adenosine A2AR Heteroreceptor Complexes in Neurodegeneration and Neuroinflammation (2018) (39)
The catalytic site structural gate of adenosine deaminase allosterically modulates ligand binding to adenosine receptors (2013) (38)
Potential of GPCRs to modulate MAPK and mTOR pathways in Alzheimer’s disease (2017) (38)
Resveratrol and Related Stilbenoids, Nutraceutical/Dietary Complements with Health-Promoting Actions: Industrial Production, Safety, and the Search for Mode of Action. (2018) (37)
Dopamine–Galanin Receptor Heteromers Modulate Cholinergic Neurotransmission in the Rat Ventral Hippocampus (2011) (37)
Epidermal growth factor (EGF)-induced up-regulation and agonist- and antagonist-induced desensitization and internalization of A1 adenosine receptors in a pituitary-derived cell line (1999) (37)
Hormetic and Mitochondria-Related Mechanisms of Antioxidant Action of Phytochemicals (2019) (37)
Pharmacokinetic investigation of sildenafil using positron emission tomography and determination of its effect on cerebrospinal fluid cGMP levels (2016) (37)
The neuronal Ca2+-binding protein 2 (NECAB2) interacts with the adenosine A2A receptor and modulates the cell surface expression and function of the receptor (2007) (37)
Immunolocalization of A1 Adenosine Receptors in Mammalian Spermatozoa (2000) (37)
Heterogeneous localization of some purine enzymes in subcellular fractions of rat brain and cerebellum (1986) (36)
Dopamine in Health and Disease: Much More Than a Neurotransmitter (2021) (36)
On the Nested Hierarchical Organization of CNS: Basic Characteristics of Neuronal Molecular Networks (2003) (35)
Chemical rules on the assessment of antioxidant potential in food and food additives aimed at reducing oxidative stress and neurodegeneration. (2017) (35)
Brain Dopamine Transmission in Health and Parkinson's Disease: Modulation of Synaptic Transmission and Plasticity Through Volume Transmission and Dopamine Heteroreceptors (2018) (35)
Neuroprotective potential of adenosine A2A and cannabinoid CB1 receptor antagonists in an animal model of Parkinson disease. (2014) (34)
Experimental data using candesartan and captopril indicate no double-edged sword effect in COVID-19 (2021) (33)
A Role for Interleukin-12 in the Regulation of T Cell Plasma Membrane Compartmentation* (2003) (33)
Computer simulation of purine metabolism. (1984) (33)
On the Molecular Basis of the Receptor Mosaic Hypothesis of the Engram (2004) (33)
Heptaspanning membrane receptors and cytoskeletal/scaffolding proteins (2007) (33)
Novel ergopeptides as dual ligands for adenosine and dopamine receptors. (2007) (32)
Biased receptor functionality versus biased agonism in G-protein-coupled receptors (2018) (32)
Potentiation of cannabinoid signaling in microglia by adenosine A2A receptor antagonists (2019) (32)
A new strategy for the evaluation of force parameters from quantum mechanical computations (1991) (32)
Age-related mitochondrial alterations without neuronal loss in the hippocampus of a transgenic model of Alzheimer's disease. (2013) (32)
Neuroprotective effect of L-DOPA co-administered with the adenosine A2A receptor agonist CGS 21680 in an animal model of Parkinson’s disease (2004) (32)
Chromenopyrazole, a Versatile Cannabinoid Scaffold with in Vivo Activity in a Model of Multiple Sclerosis. (2016) (31)
Immunological dysfunction in HIV‐1‐infected individuals caused by impairment of adenosine deaminase‐induced costimulation of T‐cell activation (2009) (31)
Aβ peptides as one of the crucial volume transmission signals in the trophic units and their interactions with homocysteine. Physiological implications and relevance for Alzheimer’s disease (2006) (31)
Defining the mechanism of action of 4-phenylbutyrate to develop a small-molecule-based therapy for Alzheimer's disease. (2011) (30)
Adenosine deaminase enhances T‐cell response elicited by dendritic cells loaded with inactivated HIV (2009) (29)
Neuroprotective Effect of JZL184 in MPP+-Treated SH-SY5Y Cells Through CB2 Receptors (2016) (28)
Prime time for G-protein-coupled receptor heteromers as therapeutic targets for CNS disorders: the dopamine D₁-D₃ receptor heteromer. (2010) (28)
Epigenetic drugs in Alzheimer’s disease (2013) (27)
Glutamate mGlu5-adenosine A2A-dopamine D2 receptor interactions in the striatum. Implications for drug therapy in neuro-psychiatric disorders and drug abuse (2003) (27)
Partners for adenosine A1 receptors (2007) (27)
Characterization of adenosine receptors in brush‐border membranes from pig kidney (1992) (26)
Mutual regulation between metabotropic glutamate type 1alpha receptor and caveolin proteins: from traffick to constitutive activity. (2004) (26)
Adenosine A2A Receptor Antagonists Affects NMDA Glutamate Receptor Function. Potential to Address Neurodegeneration in Alzheimer’s Disease (2020) (26)
Theoretical study of the protonation and tautomerization of adenosine, formycin, and their 2-NH2 and 2-F derivatives: functional implications in the mechanism of reaction of adenosine deaminase. (1989) (25)
Disruption of a dopamine receptor complex amplifies the actions of cocaine (2016) (25)
G‐protein‐coupled receptor heteromers or how neurons can display differently flavoured patterns in response to the same neurotransmitter (2009) (25)
Dopamine D(4) receptor, but not the ADHD-associated D(4.7) variant, forms functional heteromers with (2011) (24)
Calcium-mediated modulation of the quaternary structure and function of adenosine A2A-dopamine D2 receptor heteromers. (2010) (23)
Cocaine produces D2R-mediated conformational changes in the adenosine A(2A)R-dopamine D2R heteromer. (2010) (23)
Adenosine Deaminase Enhances the Immunogenicity of Human Dendritic Cells from Healthy and HIV-Infected Individuals (2012) (23)
The association of metabotropic glutamate receptor type 5 with the neuronal Ca2+‐binding protein 2 modulates receptor function (2009) (23)
Melatonin and the control of intraocular pressure (2020) (23)
Adenosine A 2A -Dopamine D 2 Receptor-Receptor Heteromerization QUALITATIVE AND QUANTITATIVE ASSESSMENT BY FLUORESCENCE AND BIOLUMINESCENCE ENERGY TRANSFER* □ S (2003) (22)
G‐Protein‐Coupled Receptor Heteromers as Key Players in the Molecular Architecture of the Central Nervous System (2014) (22)
Increased expression of cannabinoid CB2 and serotonin 5-HT1A heteroreceptor complexes in a model of newborn hypoxic-ischemic brain damage (2019) (21)
Ammonium toxicity in different cell lines. (1997) (21)
Adenosine deaminase regulates Treg expression in autologous T cell‐dendritic cell cocultures from patients infected with HIV‐1 (2016) (21)
Regulation of L‐Type Calcium Channels in GH4 Cells via A1 Adenosine Receptors (1997) (21)
Structure and function of adenosine receptor heteromers (2021) (21)
A2A and A2B adenosine receptors: the extracellular loop 2 determines high (A2A) or low affinity (A2B) for adenosine. (2019) (20)
Existence and theoretical aspects of homomeric and heteromeric dopamine receptor complexes and their relevance for neurological diseases (2007) (20)
Two Affinity Sites of the Cannabinoid Subtype 2 Receptor Identified by a Novel Homogeneous Binding Assay (2016) (20)
Modulation of GABA Transport by Adenosine A1R–A2AR Heteromers, Which Are Coupled to Both Gs- and Gi/o-Proteins (2011) (20)
Identification and rejection of outliers in enzyme kinetics. (1988) (20)
Gi protein coupling to adenosine A1–A2A receptor heteromers in human brain caudate nucleus (2010) (19)
Phosphodiesterase inhibition in cognitive decline. (2014) (19)
Targeting CB1 and GPR55 Endocannabinoid Receptors as a Potential Neuroprotective Approach for Parkinson’s Disease (2019) (19)
SARS-CoV-2 as a Factor to Disbalance the Renin–Angiotensin System: A Suspect in the Case of Exacerbated IL-6 Production (2020) (19)
Loss of Parvalbumin-Positive Neurons From the Globus Pallidus in Animal Models of Parkinson Disease (2012) (18)
Cannabinoid receptors CB 1 and CB 2 form functional heteromers in the brain # (2012) (18)
The binding of [3H]R‐PIA to A1 adenosine receptors produces a conversion of the high‐ to the low‐affinity state (1991) (18)
Fuxe, K. et al. Intramembrane receptor-receptor interactions: a novel principle in molecular medicine. J. Neural Transm. 114, 49-75 (2007) (18)
Biological potential of varinic-, minor-, and acidic phytocannabinoids. (2020) (18)
Recent Advances in the Potential of Cannabinoids for Neuroprotection in Alzheimer's, Parkinson's, and Huntington's Diseases. (2020) (17)
Interactions between ibuprofen, ACE2, renin‐angiotensin system, and spike protein in the lung. Implications for COVID‐19 (2021) (17)
Ecto‐adenosine deaminase: An ecto‐enzyme and a costimulatory protein acting on a variety of cell surface receptors (1998) (17)
Potential of caveolae in the therapy of cardiovascular and neurological diseases (2014) (17)
Maternal imprinting on cognition markers of wild type and transgenic Alzheimer’s disease model mice (2018) (17)
Orexin A/Hypocretin Modulates Leptin Receptor-Mediated Signaling by Allosteric Modulations Mediated by the Ghrelin GHS-R1A Receptor in Hypothalamic Neurons (2018) (17)
A method for binding parameters estimation of A1 adenosine receptor subtype: a practical approach. (1990) (17)
Experimental and computational analysis of biased agonism on full-length and a C-terminally truncated adenosine A2A receptor (2020) (17)
Biochemical systems theory: increasing predictive power by using second-order derivatives measurements. (1991) (17)
Adenosine A 2 B Receptors Behave as an Alternative Anchoring Protein for Cell Surface Adenosine Deaminase in Lymphocytes and Cultured Cells (2000) (17)
The pharmacological profile of L-glutamate transport in human NT2 neurones is consistent with excitatory amino acid transporter 2. (1998) (17)
Synthesis and Evaluation of 13N-Labelled Azo Compounds for β-Amyloid Imaging in Mice (2014) (16)
Adenosine Receptors in Myelin Fractions and Subtractions: The Effect of the Agonist (R)‐Phenylisopropyladenosine on Myelin Membrane Microviscosity (1991) (16)
Microglial Adenosine Receptors: From Preconditioning to Modulating the M1/M2 Balance in Activated Cells (2021) (16)
Abeta peptides as one of the crucial volume transmission signals in the trophic units and their interactions with homocysteine. Physiological implications and relevance for Alzheimer's disease. (2007) (15)
A computer program for enzyme kinetics that combines model discrimination, parameter refinement and sequential experimental design. (1986) (15)
Glucocerebrosidase Mutations and Synucleinopathies. Potential Role of Sterylglucosides and Relevance of Studying Both GBA1 and GBA2 Genes (2018) (15)
Design of Negative and Positive Allosteric Modulators of the Cannabinoid CB2 Receptor Derived from the Natural Product Cannabidiol. (2021) (15)
A quantum chemical study of the enzymatic deamination of benzoadenine derivatives. A theoretical model of the interactions occurring between nucleosides and the active site of adenosine deaminase. (1990) (15)
Cocaine Effects on Dopaminergic Transmission Depend on a Balance between Sigma-1 and Sigma-2 Receptor Expression (2018) (15)
Adenosine A 2 A Receptor and Dopamine D 3 Receptor Interactions : Evidence of Functional A 2 A / D 3 Heteromeric Complexes (2005) (14)
Adenosine/dopamine receptor‐receptor interactions in the central nervous system (2001) (14)
A Hybrid Indoloquinolizidine Peptide as Allosteric Modulator of Dopamine D1 Receptors (2010) (14)
Enzyme kinetic studies from progress curves. (1986) (14)
Theoretical study of the hydroxyl nucleophilic attack on the 6-aminopyrimidine molecule: functional implications in the reaction mechanism of nucleoside deaminative enzymes (1990) (14)
Neurotransmitter receptor heteromers in neurodegenerative diseases and neural plasticity (2009) (14)
N-Methyl-D-Aspartate Receptor Link to the MAP Kinase Pathway in Cortical and Hippocampal Neurons and Microglia Is Dependent on Calcium Sensors and Is Blocked by α-Synuclein, Tau, and Phospho-Tau in Non-transgenic and Transgenic APPSw,Ind Mice (2018) (14)
Indoloquinolizidine–Peptide Hybrids as Multiple Agonists for D1 and D2 Dopamine Receptors (2009) (13)
Adenosine Receptor Antagonists to Combat Cancer and to Boost Anti-Cancer Chemotherapy and Immunotherapy (2021) (13)
Modulation of adenosine agonist [3H]N6-(R)-phenylisopropyladenosine binding to pig brain cortical membranes by changes of membrane fluidity and of medium physicochemical characteristics. (1992) (13)
Differential Neuroprotective Effects of 5′-Deoxy-5′-Methylthioadenosine (2014) (13)
Expression of A 2 B adenosine receptors in human lymphocytes : their role in T cell activation (1999) (13)
Presynaptic P2X1-3 and α3-containing nicotinic receptors assemble into functionally interacting ion channels in the rat hippocampus (2016) (13)
Ecto-ADA in the development of the immune system. (1998) (13)
A genomics approach identifies selective effects of trans-resveratrol in cerebral cortex neuron and glia gene expression (2017) (12)
Adenine nucleotides and adenosine metabolism in pig kidney proximal tubule membranes (1993) (12)
A model for adenosine transport and metabolism. (1992) (12)
Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB2 Receptor** (2020) (12)
Cocaine Blocks Effects of Hunger Hormone, Ghrelin, Via Interaction with Neuronal Sigma-1 Receptors (2018) (12)
Control analysis of systems having two steps catalyzed by the same protein molecule in unbranched chains. (1990) (12)
Simulation of the purine nucleotide cycle as an anaplerotic process in skeletal muscle. (1987) (12)
An ACE2/Mas-related receptor MrgE axis in dopaminergic neuron mitochondria (2021) (12)
Detection of receptor heteromers involving dopamine receptors by the sequential BRET-FRET technology. (2013) (11)
Increased expression with differential subcellular location of cytidine deaminase APOBEC3G in human CD4+ T‐cell activation and dendritic cell maturation (2016) (11)
N-Methyl-D-aspartate (NMDA) and cannabinoid CB2 receptors form functional complexes in cells of the central nervous system: insights into the therapeutic potential of neuronal and microglial NMDA receptors (2021) (11)
Expression of GPR55 and either cannabinoid CB1 or CB2 heteroreceptor complexes in the caudate, putamen, and accumbens nuclei of control, parkinsonian, and dyskinetic non-human primates (2020) (11)
Expression of Melatonin and Dopamine D3 Receptor Heteromers in Eye Ciliary Body Epithelial Cells and Negative Correlation with Ocular Hypertension (2020) (11)
The Old and New Visions of Biased Agonism Through the Prism of Adenosine Receptor Signaling and Receptor/Receptor and Receptor/Protein Interactions (2021) (11)
A program for the numerical integration of enzyme kinetic equations using small computers. (1984) (10)
Genes Implicated in Familial Parkinson’s Disease Provide a Dual Picture of Nigral Dopaminergic Neurodegeneration with Mitochondria Taking Center Stage (2021) (10)
Biotin ergopeptide probes for dopamine receptors. (2011) (10)
Lessons on Differential Neuronal-Death-Vulnerability from Familial Cases of Parkinson’s and Alzheimer’s Diseases (2019) (10)
Role of Histidine Residues in Agonist and Antagonist Binding Sites of A1 Adenosine Receptor (1993) (10)
Phenyl Acyl Acids Attenuate the Unfolded Protein Response in Tunicamycin-Treated Neuroblastoma Cells (2013) (10)
Effect of phospholipases and proteases on the [3H]N6‐(R)‐phenylisopropyladenosine ([3H]R‐PIA) binding to A1 adenosine receptors from pig cerebral cortex (1991) (10)
Past , present and future of A 2 A adenosine receptor antagonists in the therapy of Parkinson ’ s disease (2011) (10)
Fitting integrated enzyme rate equations to progress curves with the use of a weighting matrix. (1991) (9)
Differential effect of amphetamine over the corticotropin-releasing factor CRF2 receptor, the orexin OX1 receptor and the CRF2-OX1 heteroreceptor complex (2019) (9)
Cocaine self‐administration markedly increases dopamine D2 receptor negative cooperativity for dopamine binding: A receptor dimer‐based analysis (2010) (9)
The Epigenetic Cytocrin Pathway to the Nucleus. Epigenetic Factors, Epigenetic Mediators, and Epigenetic Traits. A Biochemist Perspective (2017) (9)
Modulation of GH4 Cell Cycle via A1 Adenosine Receptors (1997) (9)
Angiotensin AT1 and AT2 receptor heteromer expression in the hemilesioned rat model of Parkinson’s disease that increases with levodopa-induced dyskinesia (2020) (9)
Role of CD26-adenosine deaminase interaction in T cell-mediated immunity (2005) (9)
Neuronal Calcium and cAMP Cross-Talk Mediated by Cannabinoid CB1 Receptor and EF-Hand Calcium Sensor Interactions (2018) (9)
HIV-1 envelope gp120 and viral particles block adenosine deaminase binding to human CD26. (1997) (9)
The Heteromeric Complex Formed by Dopamine Receptor D5 and CCR9 Leads the Gut Homing of CD4+ T Cells Upon Inflammation (2021) (8)
Hints on the Lateralization of Dopamine Binding to D1 Receptors in Rat Striatum (2016) (8)
N-ethylmaleimide affects agonist binding to A1 adenosine receptors differently in the presence than in the absence of ligand. (1991) (8)
Theoretical Approximation to the Reaction Mechanism of Adenosine Deaminase (1989) (8)
Understanding the Added Value of G-Protein-Coupled Receptor Heteromers (2014) (8)
Determination of the conformational preferences of adenosine at the active site of adenosine deaminase (1990) (8)
Phosphorylation of adenosine in renal brush-border membrane vesicles by an exchange reaction catalysed by adenosine kinase. (1994) (8)
The distribution of A1 adenosine receptor and 5′-nucleotidase in pig brain cortex subcellular fractions (1992) (7)
Optimal association-saturation procedure for estimating association and dissociation rate parameters in receptor studies. Application to solubilized A1 adenosine receptors. (1992) (7)
Dopamine D 1 -histamine H 3 Receptor Heteromers Provide a Selective Link to MAPK Signaling in GABAergic Neurons of (2011) (7)
Regulation of nitrobenzylthioninosine-sensitive adenosine uptake by cultured kidney cells. (1994) (7)
Novel Interactions Involving the Mas Receptor Show Potential of the Renin–Angiotensin system in the Regulation of Microglia Activation: Altered Expression in Parkinsonism and Dyskinesia (2021) (7)
Carnitine palmitoyltransferase 1C negatively regulates the endocannabinoid hydrolase ABHD6 in mice, depending on nutritional status (2021) (7)
Solubilization and molecular characterization of the nitrobenzylthioinosine binding sites from pig kidney brush-border membranes. (1994) (7)
Energy gradients for VT-signal migration in the CNS: studies on melanocortin receptors, mitochondrial uncoupling proteins and food intake. (2004) (7)
Ab initio study of the protonation and the tautomerism of the 7-aminopyrazolopyrimidine molecule (1990) (7)
GPR 55 : A therapeutic target for Parkinson ' s disease ? (2017) (7)
Kinetics of the 5′-nucleotidase and the adenosine deaminase in subcellular fractions of rat brain (1986) (7)
An old enzyme for current needs: adenosine deaminase and a dendritic cell vaccine for HIV (2012) (7)
Thermodynamic analysis of agonist and antagonist binding to membrane-bound and solubilized A1 adenosine receptors. (1993) (7)
Adenosine A2A and A3 Receptors Are Able to Interact with Each Other. A Further Piece in the Puzzle of Adenosine Receptor-Mediated Signaling (2020) (7)
Similarities and differences upon binditng of naturally occurring Δ9-tetrahydrocannabinol-derivatives to cannabinoid CB1 and CB2 receptors. (2021) (6)
Platforms for the identification of GPCR targets, and of orthosteric and allosteric modulators (2010) (6)
The sigma-1 receptor as key common factor in cocaine and food seeking behaviors. (2019) (6)
Adreno–melatonin receptor complexes control ion homeostasis and intraocular pressure ‐ their disruption contributes to hypertensive glaucoma (2020) (6)
Quantum chemical study of the electronic and conformational characteristics of adenosine and 8-substituted derivatives: functional implications in the mechanism of reaction of adenosine deaminase. (1990) (6)
Functional Complexes of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Receptors: Expression in Adult but Not Fetal Lung Tissue (2020) (6)
The meaning of the Michaelis-Menten constant: Km describes a steady-state (2019) (6)
Why have transgenic rodent models failed to successfully mimic Alzheimer’s disease. How can we develop effective drugs without them? (2019) (6)
DIMERBOW: exploring possible GPCR dimer interfaces. (2020) (5)
Detection, Analysis, and Quantification of GPCR Homo- and Heteroreceptor Complexes in Specific Neuronal Cell Populations Using the In Situ Proximity Ligation Assay (2018) (5)
Dipropylcyclopentylxanthine triggers apoptosis in Jurkat T cells by a receptor-independent mechanism (1997) (5)
Brief communication CB 2 receptor and amyloid pathology in frontal cortex of Alzheimer's disease patients (2013) (4)
Discovery of a macromolecular complex mediating the hunger suppressive actions of cocaine: Structural and functional properties (2021) (4)
A2A Receptor Homodimer-Disrupting Sequence Efficiently Delivered by a Protease-Resistant, Cyclic CPP Vector (2019) (4)
Unmasking adenosine 2A receptors (A2ARs) in monkey basal ganglia output neurons using cholera toxin subunit B (CTB) (2012) (4)
Microbiota and Other Preventive Strategies and Non-genetic Risk Factors in Parkinson’s Disease (2020) (4)
Practical Determination of Control Coefficients in Metabolic Pathways (1990) (4)
Transcriptional profiling of striatal neurons in response to single or concurrent activation of dopamine D2, adenosine A(2A) and metabotropic glutamate type 5 receptors: focus on beta-synuclein expression. (2012) (4)
Characterization of Five Purine Riboswitches in Cellular and Cell-Free Expression Systems (2021) (4)
Control analysis of transition times (1991) (4)
Decreased levels of cGMP in CSF are associated with cognitive decline and amyloid pathology in Alzheimer ’ s disease 1 Authors : (2014) (4)
Enzymes of the purine metabolism in rat brain microsomes (1986) (4)
A laboratory experiment on the purification of catalase (1986) (4)
Purification of adenosine deaminase from chicken-egg yolk by affinity column chromatography. (1990) (4)
Adenosine metabolism in kidney slices under normoxic conditions (1990) (4)
Interdependence between cooperativity and control coefficients. (1989) (3)
Natural Compounds as Guides for the Discovery of Drugs Targeting G-Protein-Coupled Receptors (2020) (3)
Cuprizone-Induced Neurotoxicity in Human Neural Cell Lines Is Mediated by a Reversible Mitochondrial Dysfunction: Relevance for Demyelination Models (2021) (3)
Role of CD 26-adenosine deaminase interaction in T cell-mediated immunity (2005) (3)
Effect of Endogenous Phospholipids on the [3H]R-Pia Binding to A1 Adenosine Receptors from PIG Cerebral Cortex (1991) (3)
Reply: Does the adenosine A2A receptor stimulate the ryanodine receptor? (2007) (3)
Adenosine‐glutamate receptor–receptor interactions in the central nervous system (2001) (3)
L.01 Novel strategies for treatment of schizophrenia and Parkinson's disease. Focus on receptor-receptor interactions in the basal ganglia (2003) (3)
Antioxidant Supplements versus Health Benefits of Brief/Intermittent Exposure to Potentially Toxic Physical or Chemical Agents (2021) (3)
Identification of the Ghrelin and Cannabinoid CB2 Receptor Heteromer Functionality and Marked Upregulation in Striatal Neurons from Offspring of Mice under a High-Fat Diet (2021) (3)
Specificity and nanomolar potency of melatonin on G-protein coupled melatonin MT1 and MT2 receptors expressed in HEK-293T human embryo kidney cells (2019) (3)
Expression of the Adenosine A2A-A3 Receptor Heteromer in Different Brain Regions and Marked Upregulation in the Microglia of the Transgenic APPSw,Ind Alzheimer’s Disease Model (2022) (3)
DIMERBOW: exploring possible GPCR dimer interfaces (2019) (3)
N-Methyl-D-Aspartate Receptor Link to the MAP Kinase Pathway in Cortical and Hippocampal Neurons and Microglia Is Dependent on Calcium Sensors and Is Blocked by α-Synuclein , Tau , and Phospho-Tau in Non-transgenic and Transgenic APP Sw , Ind Mice (2018) (3)
Adrenergic-melatonin heteroreceptor complexes are key in controlling ion homeostasis and intraocular eye pressure and their disruption contributes to hypertensive glaucoma (2019) (3)
Expression of cannabinoid CB1R–GPR55 heteromers in neuronal subtypes of the Macaca fascicularis striatum (2020) (3)
Targeted Metabolomics Shows That the Level of Glutamine, Kynurenine, Acyl-Carnitines and Lysophosphatidylcholines Is Significantly Increased in the Aqueous Humor of Glaucoma Patients (2022) (2)
Adenosine A1 Receptor in Cultured Neurons from Rat Cerebral Cortex (2000) (2)
Distribution of A1-adenosine receptors, adenosine deaminase and 5'-nucleotidase in brain and other tissues of the pig. (1990) (2)
G-protein-coupled receptor heteromers as new targets for drug development (2013) (2)
The Michaelis-Menten paradox: Km is not an equilibrium constant but a steady-state constant. (2019) (2)
The Binding Mode to Orthosteric Sites and/or Exosites Underlies the Therapeutic Potential of Drugs Targeting Cannabinoid CB2 Receptors (2022) (2)
The Michaelis-Menten paradox: Km is not an equilibrium constant but a steady-state constant. (2019) (2)
[Purine catabolism in rat brain (author's transl)]. (1981) (2)
5-Hydroxytryptamine, Glutamate, and ATP: Much More Than Neurotransmitters (2021) (2)
Similarities and differences upon binding of naturally occurring Δ 9 -tetrahydrocannabinol-derivatives to cannabinoid CB 1 and CB 2 receptors (2021) (2)
Geoffrey Burnstock (1929–2020): the finest pharmacologist and an inspiring scientist (2021) (2)
Potent and Subtype-Selective Dopamine D2 Receptor Biased Partial Agonists Discovered via an Ugi-Based Approach (2021) (2)
Heteromerization of Adenosine and Dopamine Receptor Subtypes: Relevance for Neuronal Integration in Normal and Pathological States (2002) (2)
Relationships between metabolic enzymes and the nucleoside transport. (1991) (1)
Purification of Catalase (1989) (1)
Rapid purification of adenosine deaminase from rat liver (1987) (1)
Usefulness of identifying G-protein-coupled receptor dimers for diagnosis and therapy of neurodegenerative diseases and of gliomas. (2018) (1)
Suggesting a Way to Understand the Actual Potential of Anti-Alzheimer’s Disease Drugs That Show Promise in Transgenic Mouse Models (2015) (1)
Faculty Opinions recommendation of Adenosine A1 and A2A receptor effects on G-protein cycling in beta-adrenergic stimulated ventricular membranes. (2007) (1)
Theoretical study of the acidic strength of amino acid side chains (1990) (1)
Structure of G-protein-coupled receptor heteromers (2020) (1)
Identification of Heteroreceptors Complexes and Signal Transduction Events Using Bioluminescence Resonance Energy Transfer (BRET). (2019) (1)
IFN-g UpRegulates the A 2 B Adenosine Receptor Expression in Macrophages : A Mechanism of Macrophage Deactivation 1 (1999) (1)
P.1.g.045 Neuroprotective effect of the monoacylglycerol lipase inhibitor JZL184 in a parkinsonian mouse model (2013) (1)
Antagonization of OX1 Receptor Potentiates CB2 Receptor Function in Microglia from APPSw/Ind Mice Model (2022) (1)
Heteroreceptor Complexes Implicated in Parkinson’s Disease (2017) (1)
Ghrelin and Cannabinoid Functional Interactions Mediated by Ghrelin/CB1 Receptor Heteromers That Are Upregulated in the Striatum From Offspring of Mice Under a High-Fat Diet (2021) (1)
Adenosine A2A‐cannabinoid CB1 receptor heteromers. Implications for the rewarding effects of cannabinoids (2007) (1)
Theoretical study of the tautomerism of adenosine and formycin: functional implications. (1989) (1)
Adenosine (Ado) uptake in brush-border membrane vesicles from rat kidney (BBM). (1991) (1)
The Kinetic Component in Drug Discovery: Using the Most Basic Pharmacological Concepts to Advance in Selecting Drugs to Combat CNS Diseases (2020) (1)
Methods to Identify the Signature of Trimers Formed by Three G Protein-Coupled Receptors or by Two G Protein-Coupled and One Ionotropic Receptor with Special Emphasis in the Functional Role in the Central Nervous System (2018) (1)
Science plus technology to address challenges in determining the efficacy of neuroprotective/neurorestorative therapies (2021) (1)
Enhancing cognition before clinical symptoms of dementia (2014) (1)
Real-Time G-Protein-Coupled Receptor Imaging to Understand and Quantify Receptor Dynamics (2011) (1)
P08 Thermodynamic differences between high-and low-affinity states of A, adenosine receptors (1992) (0)
Cocaine Blocks Effects of Hunger Hormone, Ghrelin, Via Interaction with Neuronal Sigma-1 Receptors (2018) (0)
3.126 EVALUATION OF DRUGS ACTING ON CB1-A2A RECEPTOR OLIGOMERS IN RAT MODELS OF PARKINSON'S DISEASE (2012) (0)
SOLUBLE AMYLOID-BETA ACTIVATES CHOLINE ACETYLTRANSFERASE INTERACTION BETWEEN N-METHYL ASPARTATE (NMDA) GLUTAMATE RECEPTORS AND CALCIUM SENSORS IN NEURONS: ALTERED INTERACTION AND CALCIUM-SENSOR MODULATION IN THE APP-PS1 MODEL OF ALZHEIMER’S DISEASE (2018) (0)
Heteroreceptor Complexes Formed by Dopamine D1, Histamine H3, and N-Methyl-D-Aspartate Glutamate Receptors as Targets to Prevent Neuronal Death in Alzheimer’s Disease (2016) (0)
NMDA receptor activation decreases adenosine A2AR function in APPSW,IND animal model of Alzheimer disease (2020) (0)
Faculty Opinions recommendation of Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors. (2006) (0)
P.3.f.005 A2A-adenosine, D2-dopamine and CB1-cannabinoid receptors in postmortem prefrontal cortex of schizophrenics (2008) (0)
NMDA receptor activation decreases adenosine A 2A R function in APP SW,IND animal model of Alzheimer disease: Molecular and cell biology/protein‐protein interactions (2020) (0)
Neuroprotective Effect of JZL184 in MPP+-Treated SH-SY5Y Cells Through CB2 Receptors (2015) (0)
Performance Indices in Metabolic Systems: a Criterion for Evaluating Effectiveness in Metabolic Regulation (1990) (0)
Neurochemical evidence supporting dopamine D1–D2 receptor heteromers in the striatum of the long-tailed macaque: changes following dopaminergic manipulation (2016) (0)
Analysis and Quantification of GPCR Allosteric Receptor–Receptor Interactions Using Radioligand Binding Assays: The A2AR-D2R Heteroreceptor Complex Example (2018) (0)
Regulation of Expression of Cannabinoid CB2 and Serotonin 5HT1A Receptor Complexes by Cannabinoids in Animal Models of Hypoxia and in Oxygen/Glucose-Deprived Neurons (2022) (0)
Cross-communication between Gi and Gs in a G-protein-coupled receptor heterotetramer guided by a receptor C-terminal domain (2018) (0)
Novel Modulator of T Cell Activation Glutamate Released by Dendritic Cells as a (2006) (0)
NeurophysiologyandPharmacology,PsychiatryCentreofExcellenceforDrugDiscovery,GlaxoSmithKlinePharmaceuticals, Harlow,EssexCM195AW,UnitedKingdom (2007) (0)
An improved method for the preparation of rat brain microsomes. (1986) (0)
INTERACTION BETWEEN N-METHYL ASPARTATE (NMDA) GLUTAMATE RECEPTORS AND CALCIUM SENSORS IN NEURONS: ALTERED INTERACTION AND CALCIUM-SENSOR MODULATION IN THE APP-PS1 MODEL OF ALZHEIMER’S DISEASE (2018) (0)
ArticleAdenosine A (2020) (0)
NEUROPROTECTIVE EFFECT OF CANNABINOID RECEPTORS IN NEUROINFLAMATION (2017) (0)
Response to Drs. Straub and Jessop (2008) (0)
Mandarin Translations (2010) (0)
Transport de nucleòsids (1995) (0)
Humans and Caffeine—A Very Long Relationship (2017) (0)
ADENOSINE A2A RECEPTOR ACTIVATION ATTENUATES NMDA RECEPTOR FUNCTION IN ALZHEIMER DISEASE (2019) (0)
Application of Progress Curve Analysis to Enzyme Kinetic Studies Using Radioactive Measurements (1991) (0)
Novel Interactions between Mas and Angiotensin Receptors and Their Functionality Modulatory Role for the Brain RAS (2021) (0)
Smart cell-surface receptors: On the 2012 Nobel Prize in Chemistry, awarded to Robert J. Lefkowitz and Brian K. Kobilka (2013) (0)
RESEARCH ARTICLE Synthesis and Evaluation of 13 N-Labelled Azo Compounds for β-Amyloid Imaging in Mice (2013) (0)
A1R–A2AR heteromers coupled to Gs and Gi/0 proteins modulate GABA transport into astrocytes (2013) (0)
Amyloid Beta Precursor Protein: Proper Credit for the Basic Biochemical Properties of the Most Studied Protein in the 21 st Century * (2014) (0)
Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with Gi and Gs (2016) (0)
SIMCODE: A program for simulating point mutations in genomic DNA (1985) (0)
Effect of σ 1 receptor ligands on σ 1 -D 2 receptor heteromer. (2013) (0)
Stronger Dopamine D1 Receptor-Mediated Neurotransmission in Dyskinesia (2014) (0)
Interaction of trans-acting factors with the proximal promoter of the mouse alpha-fetoprotein gene. (1992) (0)
A1 Adenosine receptors can occur manifesting two kinetic components of 8-cyclopentyl-1,3-[3H]dipropylxanthine ([3H]DPCPX) binding (1994) (0)
Angiotensin AT1 and AT2 receptors heteromer expression in microglia correlates with Parkinson’s disease progression in the hemilesioned rat model of the disease (2020) (0)
Computer-based learning of cooperativity and allostery (1985) (0)
Round table discussion: Glia is centrally involved in the pathogenic process of degenerative diseases and should be a therapeutic target (Session 39- Neurodegenerative Diseases) (2019) (0)
Multiple ligands applied to dopamine and adenosine receptors (2007) (0)
Cholesterol in autism spectrum disorders (2021) (0)
F1000Prime recommendation of Discovery of endogenous catecholamines in lymphocytes and evidence for catecholamine regulation of lymphocyte function via an autocrine loop. (2007) (0)
Expression and Impact of Adenosine A3 Receptors on Calcium Homeostasis in Human Right Atrium (2023) (0)
Interaction of trans-acting factors with the proximal promoter of the mouse α-fetoprotein gene (1992) (0)
Adenosine Receptors as a Paradigm to Identify Dimer/Oligomers of G-Protein-Coupled Receptors and as Targets in Parkinson’s Disease and Schizophrenia (2018) (0)
STRIATUM RECEPTOR INTERACTIONS IN THE D3 - FOR A ROLE OF SYNERGISTIC D1 Receptor Heteromers: INDICATIONS 3 D - 1 Identification of Dopamine D Mechanisms of Signal Transduction: (2014) (0)
FOR A ROLE OF SYNERGISTIC D 1 Receptor Heteromers : INDICATIONS 3 D − 1 Identification of Dopamine D Mechanisms of Signal Transduction : (2008) (0)
Author ' s personal copy The emergence of neurotransmitters as immune modulators (2007) (0)
Cytochemical demonstration of 5′-nucleotidase in rat brain synaptosomes (1987) (0)
Adenosine Receptors as a Paradigm to Identify Dimer/Oligomers of G-Protein-Coupled Receptors and as Targets in Parkinson’s Disease and Schizophrenia (2018) (0)
Front cover: Health benefits of methylxanthines in neurodegenerative diseases (2017) (0)
Introductory and Basic aspects (2008) (0)
Protein factors involved in the expression of the alpha-fetoprotein gene. (1991) (0)
Protein factors involved in the expression of the α-fetoprotein gene (1991) (0)
Dipropylcyclopentylxanthine triggers apoptosis in cells from patients with myeloid leukaemia (2004) (0)
Methamphetamine Blocks Adenosine A2A Receptor Activation via Sigma 1 and Cannabinoid CB1 Receptors (2021) (0)
Identification of a Tool Compound to Study the Mechanisms of Functional Selectivity between D2 and D3 Dopamine Receptors (2018) (0)
Orexin A/Hypocretin Modulates Leptin Receptor-Mediated Signaling by Allosteric Modulations Mediated by the Ghrelin GHS-R1A Receptor in Hypothalamic Neurons (2017) (0)
Hints on the Lateralization of Dopamine Binding to D1 Receptors in Rat Striatum (2015) (0)
Chapter 4.3. Pharmacology (2008) (0)

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What Schools Are Affiliated With Rafael Augusto Lopes Franco?

Rafael Augusto Lopes Franco is affiliated with the following schools:

University of Navarra
University of Barcelona

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