Rafael Augusto Lopes Franco
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Rafael Augusto Lopes Francobiology Degrees
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#14233
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Neuroscience
#1727
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#1781
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Biology
Rafael Augusto Lopes Franco's Degrees
- Bachelors Biology University of São Paulo
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(Suggest an Edit or Addition)Rafael Augusto Lopes Franco's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Presynaptic Control of Striatal Glutamatergic Neurotransmission by Adenosine A1–A2A Receptor Heteromers (2006) (567)
- Coaggregation, Cointernalization, and Codesensitization of Adenosine A2A Receptors and Dopamine D2Receptors* (2002) (506)
- Alternatively activated microglia and macrophages in the central nervous system (2015) (501)
- Dopamine D1 and adenosine A1 receptors form functionally interacting heteromeric complexes. (2000) (464)
- Adenosine A2A-Dopamine D2 Receptor-Receptor Heteromerization (2003) (427)
- Building a new conceptual framework for receptor heteromers. (2009) (376)
- Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: Implications for striatal neuronal function (2002) (369)
- Molecular Mechanisms and Therapeutical Implications of Intramembrane Receptor/Receptor Interactions among Heptahelical Receptors with Examples from the Striatopallidal GABA Neurons (2003) (323)
- Detection of heteromerization of more than two proteins by sequential BRET-FRET (2008) (296)
- Cell surface adenosine deaminase: Much more than an ectoenzyme (1997) (258)
- Receptor heteromerization in adenosine A2A receptor signaling (2003) (254)
- Adenosine receptor–dopamine receptor interactions in the basal ganglia and their relevance for brain function (2007) (246)
- An update on adenosine A2A-dopamine D2 receptor interactions: implications for the function of G protein-coupled receptors. (2008) (242)
- Striatal Adenosine A2A and Cannabinoid CB1 Receptors Form Functional Heteromeric Complexes that Mediate the Motor Effects of Cannabinoids (2007) (240)
- Metabotropic glutamate type 5, dopamine D2 and adenosine A2a receptors form higher‐order oligomers in living cells (2009) (239)
- CD26, adenosine deaminase, and adenosine receptors mediate costimulatory signals in the immunological synapse. (2005) (238)
- Adenosine A2A and dopamine D2 heteromeric receptor complexes and their function (2007) (210)
- IFN-gamma up-regulates the A2B adenosine receptor expression in macrophages: a mechanism of macrophage deactivation. (1999) (208)
- Cannabinoid Receptors CB1 and CB2 Form Functional Heteromers in Brain* (2012) (204)
- Identification of Dopamine D1–D3 Receptor Heteromers (2008) (203)
- Phosphodiesterases as therapeutic targets for Alzheimer's disease. (2012) (195)
- Combining mass spectrometry and pull-down techniques for the study of receptor heteromerization. Direct epitope-epitope electrostatic interactions between adenosine A2A and dopamine D2 receptors. (2004) (194)
- Aspects of the general biology of adenosine A2A signaling (2007) (192)
- Mechanisms of cannabidiol neuroprotection in hypoxic–ischemic newborn pigs: Role of 5HT1A and CB2 receptors (2013) (179)
- Metabotropic Glutamate 1α and Adenosine A1 Receptors Assemble into Functionally Interacting Complexes* (2001) (179)
- Homodimerization of adenosine A2A receptors: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer (2003) (178)
- Evidence for Adenosine/Dopamine Receptor Interactions: Indications for Heteromerization (2000) (166)
- Antagonistic cannabinoid CB1/dopamine D2 receptor interactions in striatal CB1/D2 heteromers. A combined neurochemical and behavioral analysis (2008) (165)
- Direct involvement of σ-1 receptors in the dopamine D1 receptor-mediated effects of cocaine (2010) (161)
- Interactions between histamine H3 and dopamine D2 receptors and the implications for striatal function (2008) (160)
- Role of glutamate on T-cell mediated immunity (2007) (159)
- A1 Adenosine Receptors Accumulate in Neurodegenerative Structures in Alzheimer's Disease and Mediate Both Amyloid Precursor Protein Processing and Tau Phosphorylation and Translocation (2003) (158)
- Functional relevance of neurotransmitter receptor heteromers in the central nervous system (2007) (157)
- Sildenafil restores cognitive function without affecting β‐amyloid burden in a mouse model of Alzheimer's disease (2011) (156)
- Successful therapies for Alzheimer’s disease: why so many in animal models and none in humans? (2014) (152)
- Adenosine A2A receptor stimulation potentiates nitric oxide release by activated microglia (2005) (152)
- Health Benefits of Methylxanthines in Cacao and Chocolate (2013) (152)
- Marked changes in signal transduction upon heteromerization of dopamine D1 and histamine H3 receptors (2009) (152)
- Past, present and future of A(2A) adenosine receptor antagonists in the therapy of Parkinson's disease. (2011) (149)
- Circadian-Related Heteromerization of Adrenergic and Dopamine D4 Receptors Modulates Melatonin Synthesis and Release in the Pineal Gland (2012) (148)
- Adenosine A1-A2A receptor heteromers: new targets for caffeine in the brain. (2008) (145)
- Immunological identification of A1 adenosine receptors in brain cortex (1995) (144)
- Adenosine A2A-dopamine D2 receptor-receptor heteromers. Targets for neuro-psychiatric disorders. (2004) (142)
- Glutamate Released by Dendritic Cells as a Novel Modulator of T Cell Activation1 (2006) (142)
- CB2 receptor and amyloid pathology in frontal cortex of Alzheimer's disease patients (2013) (141)
- Expression of A2B adenosine receptors in human lymphocytes: their role in T cell activation. (1999) (138)
- Striatal Pre- and Postsynaptic Profile of Adenosine A2A Receptor Antagonists (2011) (133)
- Cocaine Inhibits Dopamine D2 Receptor Signaling via Sigma-1-D2 Receptor Heteromers (2013) (131)
- Group I Metabotropic Glutamate Receptors Mediate a Dual Role of Glutamate in T Cell Activation* (2004) (128)
- Adenosine–cannabinoid receptor interactions. Implications for striatal function (2010) (127)
- Tadalafil crosses the blood–brain barrier and reverses cognitive dysfunction in a mouse model of AD (2013) (125)
- Expression of the mRNA coding the cannabinoid receptor 2 in the pallidal complex of Macaca fascicularis (2011) (124)
- Adenosine A2A Receptor and Dopamine D3 Receptor Interactions: Evidence of Functional A2A/D3 Heteromeric Complexes (2005) (123)
- The emergence of neurotransmitters as immune modulators. (2007) (122)
- Adenosine A2A receptor-antagonist/dopamine D2 receptor-agonist bivalent ligands as pharmacological tools to detect A2A-D2 receptor heteromers. (2009) (122)
- Adenosine A2B receptors behave as an alternative anchoring protein for cell surface adenosine deaminase in lymphocytes and cultured cells. (2001) (120)
- Adenosine receptor‐mediated modulation of dopamine release in the nucleus accumbens depends on glutamate neurotransmission and N‐methyl‐d‐aspartate receptor stimulation (2004) (120)
- Understanding the Functional Plasticity in Neural Networks of the Basal Ganglia in Cocaine Use Disorder: A Role for Allosteric Receptor-Receptor Interactions in A2A-D2 Heteroreceptor Complexes (2016) (120)
- Adenosine Deaminase and A1 Adenosine Receptors Internalize Together following Agonist-induced Receptor Desensitization* (1998) (120)
- Neurotransmitter receptor heteromers and their integrative role in ‘local modules’: The striatal spine module (2007) (119)
- Dopamine D1-histamine H3 Receptor Heteromers Provide a Selective Link to MAPK Signaling in GABAergic Neurons of the Direct Striatal Pathway* (2010) (119)
- Binding and Signaling Studies Disclose a Potential Allosteric Site for Cannabidiol in Cannabinoid CB2 Receptors (2017) (119)
- Detection of Heteromers Formed by Cannabinoid CB1, Dopamine D2, and Adenosine A2A G-Protein-Coupled Receptors by Combining Bimolecular Fluorescence Complementation and Bioluminescence Energy Transfer (2008) (117)
- A1R–A2AR heteromers coupled to Gs and Gi/0 proteins modulate GABA transport into astrocytes (2013) (117)
- The relevance of theobromine for the beneficial effects of cocoa consumption (2015) (115)
- Intramembrane receptor–receptor interactions: a novel principle in molecular medicine (2006) (113)
- Working memory deficits in transgenic rats overexpressing human adenosine A2A receptors in the brain (2007) (113)
- Targeting Cannabinoid CB2 Receptors in the Central Nervous System. Medicinal Chemistry Approaches with Focus on Neurodegenerative Disorders (2016) (110)
- Interactions between Intracellular Domains as Key Determinants of the Quaternary Structure and Function of Receptor Heteromers* (2010) (108)
- Detection of higher‐order G protein‐coupled receptor oligomers by a combined BRET–BiFC technique (2008) (108)
- Basic Pharmacological and Structural Evidence for Class A G-Protein-Coupled Receptor Heteromerization (2016) (105)
- Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with Gi and Gs (2016) (104)
- The Adenosine A2A Receptor Interacts with the Actin-binding Protein α-Actinin* (2003) (104)
- Comodulation of CXCR4 and CD26 in Human Lymphocytes* (2001) (102)
- Involvement of caveolin in ligand-induced recruitment and internalization of A(1) adenosine receptor and adenosine deaminase in an epithelial cell line. (2001) (101)
- Heteromerization of GPR55 and cannabinoid CB2 receptors modulates signalling (2014) (101)
- Adenosine Receptor Heteromers and their Integrative Role in Striatal Function (2007) (101)
- Immunodensity and mRNA expression of A2A adenosine, D2 dopamine, and CB1 cannabinoid receptors in postmortem frontal cortex of subjects with schizophrenia: effect of antipsychotic treatment (2009) (100)
- Involvement of adenosine A2A and dopamine receptors in the locomotor and sensitizing effects of cocaine (2006) (93)
- Heterodimeric adenosine receptors: a device to regulate neurotransmitter release (2006) (93)
- Looking for the role of cannabinoid receptor heteromers in striatal function (2009) (92)
- Ligand-induced phosphorylation, clustering, and desensitization of A1 adenosine receptors. (1997) (92)
- Basic Concepts in G-Protein-Coupled Receptor Homo- and Heterodimerization (2007) (89)
- Detection of cannabinoid receptors CB1 and CB2 within basal ganglia output neurons in macaques: changes following experimental parkinsonism (2014) (88)
- Regulation of heptaspanning-membrane-receptor function by dimerization and clustering. (2003) (87)
- Dopamine D4 receptor, but not the ADHD-associated D4.7 variant, forms functional heteromers with the dopamine D2S receptor in the brain (2011) (87)
- GPCR homomers and heteromers: a better choice as targets for drug development than GPCR monomers? (2009) (87)
- Receptor-heteromer mediated regulation of endocannabinoid signaling in activated microglia. Role of CB1 and CB2 receptors and relevance for Alzheimer’s disease and levodopa-induced dyskinesia (2018) (87)
- The Two-State Dimer Receptor Model: A General Model for Receptor Dimers (2006) (86)
- l-DOPA-treatment in primates disrupts the expression of A2A adenosine–CB1 cannabinoid–D2 dopamine receptor heteromers in the caudate nucleus (2014) (83)
- CB1 and GPR55 receptors are co-expressed and form heteromers in rat and monkey striatum (2014) (80)
- Receptor–receptor interactions involving adenosine A1 or dopamine D1 receptors and accessory proteins (2006) (79)
- Up‐regulation of the Kv3.4 potassium channel subunit in early stages of Alzheimer's disease (2004) (79)
- Adenosine Deaminase Interacts with A1 Adenosine Receptors in Pig Brain Cortical Membranes (1996) (79)
- Striatal plasticity at the network level. Focus on adenosine A2A and D2 interactions in models of Parkinson's Disease. (2004) (79)
- Mitochondrial angiotensin receptors in dopaminergic neurons. Role in cell protection and aging-related vulnerability to neurodegeneration (2016) (78)
- Heteromeric Nicotinic Acetylcholine–Dopamine Autoreceptor Complexes Modulate Striatal Dopamine Release (2007) (76)
- l-DOPA disrupts adenosine A2A–cannabinoid CB1–dopamine D2 receptor heteromer cross-talk in the striatum of hemiparkinsonian rats: Biochemical and behavioral studies (2014) (76)
- Ligand-induced caveolae-mediated internalization of A1 adenosine receptors: morphological evidence of endosomal sorting and receptor recycling. (2003) (76)
- Old and new ways to calculate the affinity of agonists and antagonists interacting with G-protein-coupled monomeric and dimeric receptors: the receptor-dimer cooperativity index. (2007) (76)
- Adenosine A2A receptors are expressed in human atrial myocytes and modulate spontaneous sarcoplasmic reticulum calcium release. (2006) (74)
- Dimer-based model for heptaspanning membrane receptors. (2005) (74)
- Decreased levels of guanosine 3′, 5′‐monophosphate (cGMP) in cerebrospinal fluid (CSF) are associated with cognitive decline and amyloid pathology in Alzheimer's disease (2015) (74)
- The monoacylglycerol lipase inhibitor JZL184 is neuroprotective and alters glial cell phenotype in the chronic MPTP mouse model (2014) (73)
- Cannabigerol Action at Cannabinoid CB1 and CB2 Receptors and at CB1–CB2 Heteroreceptor Complexes (2018) (73)
- Calcium mobilization in Jurkat cells via A2b adenosine receptors (1997) (73)
- Role of electrostatic interaction in receptor-receptor heteromerization (2007) (72)
- Abnormal calcium handling in atrial fibrillation is linked to up-regulation of adenosine A2A receptors. (2011) (72)
- A First-in-Class Small-Molecule that Acts as a Dual Inhibitor of HDAC and PDE5 and that Rescues Hippocampal Synaptic Impairment in Alzheimer’s Disease Mice (2017) (72)
- Oligomerization of G-protein-coupled receptors: a reality. (2010) (71)
- Health benefits of methylxanthines in neurodegenerative diseases. (2017) (71)
- G‐protein‐coupled receptor heteromers: function and ligand pharmacology (2008) (71)
- Solubilization of A1 adenosine receptor from pig brain: Characterization and evidence of the role of the cell membrane on the coexistence of high‐ and low‐affinity states (1990) (70)
- The Heat Shock Cognate Protein hsc73 Assembles with A1 Adenosine Receptors To Form Functional Modules in the Cell Membrane (2000) (70)
- Possible role of intramembrane receptor-receptor interactions in memory and learning via formation of long-lived heteromeric complexes: focus on motor learning in the basal ganglia. (2003) (69)
- Adenosine A2A receptor ligand recognition and signaling is blocked by A2B receptors (2018) (68)
- Adenosine deaminase binding to human CD26 is inhibited by HIV-1 envelope glycoprotein gp120 and viral particles. (1997) (68)
- Use of implicit methods from general sensitivity theory to develop a systematic approach to metabolic control. II. Complex systems. (1989) (67)
- Interactions between Calmodulin, Adenosine A2A, and Dopamine D2 Receptors* (2009) (65)
- Regulation of epithelial and lymphocyte cell adhesion by adenosine deaminase-CD26 interaction. (2002) (64)
- Molecular mechanisms involved in the adenosine A1 and A2A receptor‐induced neuronal differentiation in neuroblastoma cells and striatal primary cultures (2005) (63)
- Cannabidiol skews biased agonism at cannabinoid CB1 and CB2 receptors with smaller effect in CB1‐CB2 heteroreceptor complexes (2018) (63)
- Structures for G-Protein-Coupled Receptor Tetramers in Complex with G Proteins. (2015) (62)
- Cross-communication between Gi and Gs in a G-protein-coupled receptor heterotetramer guided by a receptor C-terminal domain (2018) (62)
- Use of implicit methods from general sensitivity theory to develop a systematic approach to metabolic control. I. Unbranched pathways. (1989) (61)
- Purinergic signaling in Parkinson's disease. Relevance for treatment (2016) (61)
- Enzymatic and extraenzymatic role of adenosine deaminase 1 in T-cell-dendritic cell contacts and in alterations of the immune function. (2007) (61)
- Phenylbutyrate is a multifaceted drug that exerts neuroprotective effects and reverses the Alzheimer´s disease-like phenotype of a commonly used mouse model. (2013) (60)
- Interactions among adenosine deaminase, adenosine A1 receptors and dopamine D1 receptors in stably cotransfected fibroblast cells and neurons (2002) (59)
- Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity. (2020) (59)
- Adenosine deaminase potentiates the generation of effector, memory, and regulatory CD4+ T cells (2011) (57)
- ATP-Sensitive K+ Channels Regulate the Concentrative Adenosine Transporter CNT2 following Activation by A1 Adenosine Receptors (2004) (56)
- GPR55: A therapeutic target for Parkinson's disease? (2017) (55)
- Chronic mild stress accelerates the onset and progression of the Alzheimer's disease phenotype in Tg2576 mice. (2012) (55)
- Allosteric modulation of dopamine D2 receptors by homocysteine. (2006) (54)
- Plasma membrane diffusion of G protein-coupled receptor oligomers. (2008) (54)
- Adenosine receptors and Parkinson's disease. Relevance of antagonistic adenosine and dopamine receptor interactions in the striatum. (2001) (53)
- Dopamine D2 and angiotensin II type 1 receptors form functional heteromers in rat striatum. (2015) (53)
- GPR40 activation leads to CREB and ERK phosphorylation in primary cultures of neurons from the mouse CNS and in human neuroblastoma cells (2014) (53)
- Reinforcing and neurochemical effects of cannabinoid CB1 receptor agonists, but not cocaine, are altered by an adenosine A2A receptor antagonist (2011) (53)
- Stronger Dopamine D1 Receptor-Mediated Neurotransmission in Dyskinesia (2015) (52)
- Human adenosine deaminase as an allosteric modulator of human A1 adenosine receptor: abolishment of negative cooperativity for [3H](R)‐pia binding to the caudate nucleus (2008) (52)
- Fatty acid amide hydrolase inhibition for the symptomatic relief of Parkinson’s disease (2016) (52)
- Role of adenosine in the control of homosynaptic plasticity in striatal excitatory synapses. (2005) (52)
- Dynamic Regulation of CXCR1 and CXCR2 Homo- and Heterodimers1 (2009) (50)
- Adenosine A2A Receptors and A2A Receptor Heteromers as Key Players in Striatal Function (2011) (50)
- Increased α-Defensins 1-3 Production by Dendritic Cells in HIV-Infected Individuals Is Associated with Slower Disease Progression (2010) (49)
- Concomitant histone deacetylase and phosphodiesterase 5 inhibition synergistically prevents the disruption in synaptic plasticity and it reverses cognitive impairment in a mouse model of Alzheimer’s disease (2015) (49)
- The cluster-arranged cooperative model: a model that accounts for the kinetics of binding to A1 adenosine receptors. (1996) (49)
- CD26 and adenosine deaminase interaction: its role in the fusion between horse membrane vesicles and spermatozoa. (1999) (48)
- CCR5/CD4/CXCR4 oligomerization prevents HIV-1 gp120IIIB binding to the cell surface (2014) (48)
- New Methods to Evaluate Colocalization of Fluorophores in Immunocytochemical Preparations as Exemplified by a Study on A2A and D2 Receptors in Chinese Hamster Ovary Cells (2005) (48)
- G protein-coupled receptor heteromers as new targets for drug development. (2010) (47)
- Adenosine A(1) receptor in cultured neurons from rat cerebral cortex: colocalization with adenosine deaminase. (2002) (47)
- Neurochemical evidence supporting dopamine D1–D2 receptor heteromers in the striatum of the long-tailed macaque: changes following dopaminergic manipulation (2016) (46)
- A2A adenosine receptor ligand binding and signalling is allosterically modulated by adenosine deaminase. (2011) (46)
- Useful pharmacological parameters for G-protein-coupled receptor homodimers obtained from competition experiments. Agonist-antagonist binding modulation. (2009) (45)
- Adenosine A2A Receptor Antagonists in Neurodegenerative Diseases: Huge Potential and Huge Challenges (2018) (45)
- Molecular and functional interaction between GPR18 and cannabinoid CB2 G‐protein‐coupled receptors. Relevance in neurodegenerative diseases (2018) (45)
- The Adenosine Receptors Present on the Plasma Membrane of Chromaffin Cells Are of the A2b Subtype (1992) (45)
- The adenosine A2A receptor interacts with the actin-binding protein alpha-actinin. (2003) (45)
- Dopamine receptor heteromeric complexes and their emerging functions. (2014) (44)
- Angiotensin type 2 receptors: Role in aging and neuroinflammation in the substantia nigra (2019) (44)
- Light resonance energy transfer-based methods in the study of G protein-coupled receptor oligomerization. (2008) (43)
- Antioxidant Defense Mechanisms in Erythrocytes and in the Central Nervous System (2019) (43)
- Actin-binding Protein α-Actinin-1 Interacts with the Metabotropic Glutamate Receptor Type 5b and Modulates the Cell Surface Expression and Function of the Receptor* (2007) (43)
- Trafficking of adenosine A2A and dopamine D2 receptors (2007) (42)
- Pharmacologic antagonism of dopamine receptor D3 attenuates neurodegeneration and motor impairment in a mouse model of Parkinson's disease (2017) (41)
- The potential of methylxanthine-based therapies in pediatric respiratory tract diseases. (2016) (41)
- Metabotropic glutamate type 1α receptor localizes in low‐density caveolin‐rich plasma membrane fractions (2003) (41)
- Alterations in Gene and Protein Expression of Cannabinoid CB2 and GPR55 Receptors in the Dorsolateral Prefrontal Cortex of Suicide Victims (2018) (40)
- How calmodulin interacts with the adenosine A(2A) and the dopamine D(2) receptors. (2008) (40)
- Pharmacological data of cannabidiol- and cannabigerol-type phytocannabinoids acting on cannabinoid CB1, CB2 and CB1/CB2 heteromer receptors. (2020) (40)
- Novel pharmacological targets based on receptor heteromers (2008) (40)
- IDENTIFICATION OF DOPAMINE D 1 -D 3 RECEPTOR HETEROMERS: INDICATIONS FOR A ROLE OF SYNERGISTIC D 1 -D 3 RECEPTOR INTERACTIONS IN THE STRIATUM* (2008) (40)
- Heteroreceptor Complexes Formed by Dopamine D1, Histamine H3, and N-Methyl-D-Aspartate Glutamate Receptors as Targets to Prevent Neuronal Death in Alzheimer’s Disease (2017) (39)
- A model of the pentose phosphate pathway in rat liver cells (1995) (39)
- Antioxidants versus Food Antioxidant Additives and Food Preservatives (2019) (39)
- Understanding the Role of Adenosine A2AR Heteroreceptor Complexes in Neurodegeneration and Neuroinflammation (2018) (39)
- The catalytic site structural gate of adenosine deaminase allosterically modulates ligand binding to adenosine receptors (2013) (38)
- Potential of GPCRs to modulate MAPK and mTOR pathways in Alzheimer’s disease (2017) (38)
- Resveratrol and Related Stilbenoids, Nutraceutical/Dietary Complements with Health-Promoting Actions: Industrial Production, Safety, and the Search for Mode of Action. (2018) (37)
- Dopamine–Galanin Receptor Heteromers Modulate Cholinergic Neurotransmission in the Rat Ventral Hippocampus (2011) (37)
- Epidermal growth factor (EGF)-induced up-regulation and agonist- and antagonist-induced desensitization and internalization of A1 adenosine receptors in a pituitary-derived cell line (1999) (37)
- Hormetic and Mitochondria-Related Mechanisms of Antioxidant Action of Phytochemicals (2019) (37)
- Pharmacokinetic investigation of sildenafil using positron emission tomography and determination of its effect on cerebrospinal fluid cGMP levels (2016) (37)
- The neuronal Ca2+-binding protein 2 (NECAB2) interacts with the adenosine A2A receptor and modulates the cell surface expression and function of the receptor (2007) (37)
- Immunolocalization of A1 Adenosine Receptors in Mammalian Spermatozoa (2000) (37)
- Heterogeneous localization of some purine enzymes in subcellular fractions of rat brain and cerebellum (1986) (36)
- Dopamine in Health and Disease: Much More Than a Neurotransmitter (2021) (36)
- On the Nested Hierarchical Organization of CNS: Basic Characteristics of Neuronal Molecular Networks (2003) (35)
- Chemical rules on the assessment of antioxidant potential in food and food additives aimed at reducing oxidative stress and neurodegeneration. (2017) (35)
- Brain Dopamine Transmission in Health and Parkinson's Disease: Modulation of Synaptic Transmission and Plasticity Through Volume Transmission and Dopamine Heteroreceptors (2018) (35)
- Neuroprotective potential of adenosine A2A and cannabinoid CB1 receptor antagonists in an animal model of Parkinson disease. (2014) (34)
- Experimental data using candesartan and captopril indicate no double-edged sword effect in COVID-19 (2021) (33)
- A Role for Interleukin-12 in the Regulation of T Cell Plasma Membrane Compartmentation* (2003) (33)
- Computer simulation of purine metabolism. (1984) (33)
- On the Molecular Basis of the Receptor Mosaic Hypothesis of the Engram (2004) (33)
- Heptaspanning membrane receptors and cytoskeletal/scaffolding proteins (2007) (33)
- Novel ergopeptides as dual ligands for adenosine and dopamine receptors. (2007) (32)
- Biased receptor functionality versus biased agonism in G-protein-coupled receptors (2018) (32)
- Potentiation of cannabinoid signaling in microglia by adenosine A2A receptor antagonists (2019) (32)
- A new strategy for the evaluation of force parameters from quantum mechanical computations (1991) (32)
- Age-related mitochondrial alterations without neuronal loss in the hippocampus of a transgenic model of Alzheimer's disease. (2013) (32)
- Neuroprotective effect of L-DOPA co-administered with the adenosine A2A receptor agonist CGS 21680 in an animal model of Parkinson’s disease (2004) (32)
- Chromenopyrazole, a Versatile Cannabinoid Scaffold with in Vivo Activity in a Model of Multiple Sclerosis. (2016) (31)
- Immunological dysfunction in HIV‐1‐infected individuals caused by impairment of adenosine deaminase‐induced costimulation of T‐cell activation (2009) (31)
- Aβ peptides as one of the crucial volume transmission signals in the trophic units and their interactions with homocysteine. Physiological implications and relevance for Alzheimer’s disease (2006) (31)
- Defining the mechanism of action of 4-phenylbutyrate to develop a small-molecule-based therapy for Alzheimer's disease. (2011) (30)
- Adenosine deaminase enhances T‐cell response elicited by dendritic cells loaded with inactivated HIV (2009) (29)
- Neuroprotective Effect of JZL184 in MPP+-Treated SH-SY5Y Cells Through CB2 Receptors (2016) (28)
- Prime time for G-protein-coupled receptor heteromers as therapeutic targets for CNS disorders: the dopamine D₁-D₃ receptor heteromer. (2010) (28)
- Epigenetic drugs in Alzheimer’s disease (2013) (27)
- Glutamate mGlu5-adenosine A2A-dopamine D2 receptor interactions in the striatum. Implications for drug therapy in neuro-psychiatric disorders and drug abuse (2003) (27)
- Partners for adenosine A1 receptors (2007) (27)
- Characterization of adenosine receptors in brush‐border membranes from pig kidney (1992) (26)
- Mutual regulation between metabotropic glutamate type 1alpha receptor and caveolin proteins: from traffick to constitutive activity. (2004) (26)
- Adenosine A2A Receptor Antagonists Affects NMDA Glutamate Receptor Function. Potential to Address Neurodegeneration in Alzheimer’s Disease (2020) (26)
- Theoretical study of the protonation and tautomerization of adenosine, formycin, and their 2-NH2 and 2-F derivatives: functional implications in the mechanism of reaction of adenosine deaminase. (1989) (25)
- Disruption of a dopamine receptor complex amplifies the actions of cocaine (2016) (25)
- G‐protein‐coupled receptor heteromers or how neurons can display differently flavoured patterns in response to the same neurotransmitter (2009) (25)
- Dopamine D(4) receptor, but not the ADHD-associated D(4.7) variant, forms functional heteromers with (2011) (24)
- Calcium-mediated modulation of the quaternary structure and function of adenosine A2A-dopamine D2 receptor heteromers. (2010) (23)
- Cocaine produces D2R-mediated conformational changes in the adenosine A(2A)R-dopamine D2R heteromer. (2010) (23)
- Adenosine Deaminase Enhances the Immunogenicity of Human Dendritic Cells from Healthy and HIV-Infected Individuals (2012) (23)
- The association of metabotropic glutamate receptor type 5 with the neuronal Ca2+‐binding protein 2 modulates receptor function (2009) (23)
- Melatonin and the control of intraocular pressure (2020) (23)
- Adenosine A 2A -Dopamine D 2 Receptor-Receptor Heteromerization QUALITATIVE AND QUANTITATIVE ASSESSMENT BY FLUORESCENCE AND BIOLUMINESCENCE ENERGY TRANSFER* □ S (2003) (22)
- G‐Protein‐Coupled Receptor Heteromers as Key Players in the Molecular Architecture of the Central Nervous System (2014) (22)
- Increased expression of cannabinoid CB2 and serotonin 5-HT1A heteroreceptor complexes in a model of newborn hypoxic-ischemic brain damage (2019) (21)
- Ammonium toxicity in different cell lines. (1997) (21)
- Adenosine deaminase regulates Treg expression in autologous T cell‐dendritic cell cocultures from patients infected with HIV‐1 (2016) (21)
- Regulation of L‐Type Calcium Channels in GH4 Cells via A1 Adenosine Receptors (1997) (21)
- Structure and function of adenosine receptor heteromers (2021) (21)
- A2A and A2B adenosine receptors: the extracellular loop 2 determines high (A2A) or low affinity (A2B) for adenosine. (2019) (20)
- Existence and theoretical aspects of homomeric and heteromeric dopamine receptor complexes and their relevance for neurological diseases (2007) (20)
- Two Affinity Sites of the Cannabinoid Subtype 2 Receptor Identified by a Novel Homogeneous Binding Assay (2016) (20)
- Modulation of GABA Transport by Adenosine A1R–A2AR Heteromers, Which Are Coupled to Both Gs- and Gi/o-Proteins (2011) (20)
- Identification and rejection of outliers in enzyme kinetics. (1988) (20)
- Gi protein coupling to adenosine A1–A2A receptor heteromers in human brain caudate nucleus (2010) (19)
- Phosphodiesterase inhibition in cognitive decline. (2014) (19)
- Targeting CB1 and GPR55 Endocannabinoid Receptors as a Potential Neuroprotective Approach for Parkinson’s Disease (2019) (19)
- SARS-CoV-2 as a Factor to Disbalance the Renin–Angiotensin System: A Suspect in the Case of Exacerbated IL-6 Production (2020) (19)
- Loss of Parvalbumin-Positive Neurons From the Globus Pallidus in Animal Models of Parkinson Disease (2012) (18)
- Cannabinoid receptors CB 1 and CB 2 form functional heteromers in the brain # (2012) (18)
- The binding of [3H]R‐PIA to A1 adenosine receptors produces a conversion of the high‐ to the low‐affinity state (1991) (18)
- Fuxe, K. et al. Intramembrane receptor-receptor interactions: a novel principle in molecular medicine. J. Neural Transm. 114, 49-75 (2007) (18)
- Biological potential of varinic-, minor-, and acidic phytocannabinoids. (2020) (18)
- Recent Advances in the Potential of Cannabinoids for Neuroprotection in Alzheimer's, Parkinson's, and Huntington's Diseases. (2020) (17)
- Interactions between ibuprofen, ACE2, renin‐angiotensin system, and spike protein in the lung. Implications for COVID‐19 (2021) (17)
- Ecto‐adenosine deaminase: An ecto‐enzyme and a costimulatory protein acting on a variety of cell surface receptors (1998) (17)
- Potential of caveolae in the therapy of cardiovascular and neurological diseases (2014) (17)
- Maternal imprinting on cognition markers of wild type and transgenic Alzheimer’s disease model mice (2018) (17)
- Orexin A/Hypocretin Modulates Leptin Receptor-Mediated Signaling by Allosteric Modulations Mediated by the Ghrelin GHS-R1A Receptor in Hypothalamic Neurons (2018) (17)
- A method for binding parameters estimation of A1 adenosine receptor subtype: a practical approach. (1990) (17)
- Experimental and computational analysis of biased agonism on full-length and a C-terminally truncated adenosine A2A receptor (2020) (17)
- Biochemical systems theory: increasing predictive power by using second-order derivatives measurements. (1991) (17)
- Adenosine A 2 B Receptors Behave as an Alternative Anchoring Protein for Cell Surface Adenosine Deaminase in Lymphocytes and Cultured Cells (2000) (17)
- The pharmacological profile of L-glutamate transport in human NT2 neurones is consistent with excitatory amino acid transporter 2. (1998) (17)
- Synthesis and Evaluation of 13N-Labelled Azo Compounds for β-Amyloid Imaging in Mice (2014) (16)
- Adenosine Receptors in Myelin Fractions and Subtractions: The Effect of the Agonist (R)‐Phenylisopropyladenosine on Myelin Membrane Microviscosity (1991) (16)
- Microglial Adenosine Receptors: From Preconditioning to Modulating the M1/M2 Balance in Activated Cells (2021) (16)
- Abeta peptides as one of the crucial volume transmission signals in the trophic units and their interactions with homocysteine. Physiological implications and relevance for Alzheimer's disease. (2007) (15)
- A computer program for enzyme kinetics that combines model discrimination, parameter refinement and sequential experimental design. (1986) (15)
- Glucocerebrosidase Mutations and Synucleinopathies. Potential Role of Sterylglucosides and Relevance of Studying Both GBA1 and GBA2 Genes (2018) (15)
- Design of Negative and Positive Allosteric Modulators of the Cannabinoid CB2 Receptor Derived from the Natural Product Cannabidiol. (2021) (15)
- A quantum chemical study of the enzymatic deamination of benzoadenine derivatives. A theoretical model of the interactions occurring between nucleosides and the active site of adenosine deaminase. (1990) (15)
- Cocaine Effects on Dopaminergic Transmission Depend on a Balance between Sigma-1 and Sigma-2 Receptor Expression (2018) (15)
- Adenosine A 2 A Receptor and Dopamine D 3 Receptor Interactions : Evidence of Functional A 2 A / D 3 Heteromeric Complexes (2005) (14)
- Adenosine/dopamine receptor‐receptor interactions in the central nervous system (2001) (14)
- A Hybrid Indoloquinolizidine Peptide as Allosteric Modulator of Dopamine D1 Receptors (2010) (14)
- Enzyme kinetic studies from progress curves. (1986) (14)
- Theoretical study of the hydroxyl nucleophilic attack on the 6-aminopyrimidine molecule: functional implications in the reaction mechanism of nucleoside deaminative enzymes (1990) (14)
- Neurotransmitter receptor heteromers in neurodegenerative diseases and neural plasticity (2009) (14)
- N-Methyl-D-Aspartate Receptor Link to the MAP Kinase Pathway in Cortical and Hippocampal Neurons and Microglia Is Dependent on Calcium Sensors and Is Blocked by α-Synuclein, Tau, and Phospho-Tau in Non-transgenic and Transgenic APPSw,Ind Mice (2018) (14)
- Indoloquinolizidine–Peptide Hybrids as Multiple Agonists for D1 and D2 Dopamine Receptors (2009) (13)
- Adenosine Receptor Antagonists to Combat Cancer and to Boost Anti-Cancer Chemotherapy and Immunotherapy (2021) (13)
- Modulation of adenosine agonist [3H]N6-(R)-phenylisopropyladenosine binding to pig brain cortical membranes by changes of membrane fluidity and of medium physicochemical characteristics. (1992) (13)
- Differential Neuroprotective Effects of 5′-Deoxy-5′-Methylthioadenosine (2014) (13)
- Expression of A 2 B adenosine receptors in human lymphocytes : their role in T cell activation (1999) (13)
- Presynaptic P2X1-3 and α3-containing nicotinic receptors assemble into functionally interacting ion channels in the rat hippocampus (2016) (13)
- Ecto-ADA in the development of the immune system. (1998) (13)
- A genomics approach identifies selective effects of trans-resveratrol in cerebral cortex neuron and glia gene expression (2017) (12)
- Adenine nucleotides and adenosine metabolism in pig kidney proximal tubule membranes (1993) (12)
- A model for adenosine transport and metabolism. (1992) (12)
- Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB2 Receptor** (2020) (12)
- Cocaine Blocks Effects of Hunger Hormone, Ghrelin, Via Interaction with Neuronal Sigma-1 Receptors (2018) (12)
- Control analysis of systems having two steps catalyzed by the same protein molecule in unbranched chains. (1990) (12)
- Simulation of the purine nucleotide cycle as an anaplerotic process in skeletal muscle. (1987) (12)
- An ACE2/Mas-related receptor MrgE axis in dopaminergic neuron mitochondria (2021) (12)
- Detection of receptor heteromers involving dopamine receptors by the sequential BRET-FRET technology. (2013) (11)
- Increased expression with differential subcellular location of cytidine deaminase APOBEC3G in human CD4+ T‐cell activation and dendritic cell maturation (2016) (11)
- N-Methyl-D-aspartate (NMDA) and cannabinoid CB2 receptors form functional complexes in cells of the central nervous system: insights into the therapeutic potential of neuronal and microglial NMDA receptors (2021) (11)
- Expression of GPR55 and either cannabinoid CB1 or CB2 heteroreceptor complexes in the caudate, putamen, and accumbens nuclei of control, parkinsonian, and dyskinetic non-human primates (2020) (11)
- Expression of Melatonin and Dopamine D3 Receptor Heteromers in Eye Ciliary Body Epithelial Cells and Negative Correlation with Ocular Hypertension (2020) (11)
- The Old and New Visions of Biased Agonism Through the Prism of Adenosine Receptor Signaling and Receptor/Receptor and Receptor/Protein Interactions (2021) (11)
- A program for the numerical integration of enzyme kinetic equations using small computers. (1984) (10)
- Genes Implicated in Familial Parkinson’s Disease Provide a Dual Picture of Nigral Dopaminergic Neurodegeneration with Mitochondria Taking Center Stage (2021) (10)
- Biotin ergopeptide probes for dopamine receptors. (2011) (10)
- Lessons on Differential Neuronal-Death-Vulnerability from Familial Cases of Parkinson’s and Alzheimer’s Diseases (2019) (10)
- Role of Histidine Residues in Agonist and Antagonist Binding Sites of A1 Adenosine Receptor (1993) (10)
- Phenyl Acyl Acids Attenuate the Unfolded Protein Response in Tunicamycin-Treated Neuroblastoma Cells (2013) (10)
- Effect of phospholipases and proteases on the [3H]N6‐(R)‐phenylisopropyladenosine ([3H]R‐PIA) binding to A1 adenosine receptors from pig cerebral cortex (1991) (10)
- Past , present and future of A 2 A adenosine receptor antagonists in the therapy of Parkinson ’ s disease (2011) (10)
- Fitting integrated enzyme rate equations to progress curves with the use of a weighting matrix. (1991) (9)
- Differential effect of amphetamine over the corticotropin-releasing factor CRF2 receptor, the orexin OX1 receptor and the CRF2-OX1 heteroreceptor complex (2019) (9)
- Cocaine self‐administration markedly increases dopamine D2 receptor negative cooperativity for dopamine binding: A receptor dimer‐based analysis (2010) (9)
- The Epigenetic Cytocrin Pathway to the Nucleus. Epigenetic Factors, Epigenetic Mediators, and Epigenetic Traits. A Biochemist Perspective (2017) (9)
- Modulation of GH4 Cell Cycle via A1 Adenosine Receptors (1997) (9)
- Angiotensin AT1 and AT2 receptor heteromer expression in the hemilesioned rat model of Parkinson’s disease that increases with levodopa-induced dyskinesia (2020) (9)
- Role of CD26-adenosine deaminase interaction in T cell-mediated immunity (2005) (9)
- Neuronal Calcium and cAMP Cross-Talk Mediated by Cannabinoid CB1 Receptor and EF-Hand Calcium Sensor Interactions (2018) (9)
- HIV-1 envelope gp120 and viral particles block adenosine deaminase binding to human CD26. (1997) (9)
- The Heteromeric Complex Formed by Dopamine Receptor D5 and CCR9 Leads the Gut Homing of CD4+ T Cells Upon Inflammation (2021) (8)
- Hints on the Lateralization of Dopamine Binding to D1 Receptors in Rat Striatum (2016) (8)
- N-ethylmaleimide affects agonist binding to A1 adenosine receptors differently in the presence than in the absence of ligand. (1991) (8)
- Theoretical Approximation to the Reaction Mechanism of Adenosine Deaminase (1989) (8)
- Understanding the Added Value of G-Protein-Coupled Receptor Heteromers (2014) (8)
- Determination of the conformational preferences of adenosine at the active site of adenosine deaminase (1990) (8)
- Phosphorylation of adenosine in renal brush-border membrane vesicles by an exchange reaction catalysed by adenosine kinase. (1994) (8)
- The distribution of A1 adenosine receptor and 5′-nucleotidase in pig brain cortex subcellular fractions (1992) (7)
- Optimal association-saturation procedure for estimating association and dissociation rate parameters in receptor studies. Application to solubilized A1 adenosine receptors. (1992) (7)
- Dopamine D 1 -histamine H 3 Receptor Heteromers Provide a Selective Link to MAPK Signaling in GABAergic Neurons of (2011) (7)
- Regulation of nitrobenzylthioninosine-sensitive adenosine uptake by cultured kidney cells. (1994) (7)
- Novel Interactions Involving the Mas Receptor Show Potential of the Renin–Angiotensin system in the Regulation of Microglia Activation: Altered Expression in Parkinsonism and Dyskinesia (2021) (7)
- Carnitine palmitoyltransferase 1C negatively regulates the endocannabinoid hydrolase ABHD6 in mice, depending on nutritional status (2021) (7)
- Solubilization and molecular characterization of the nitrobenzylthioinosine binding sites from pig kidney brush-border membranes. (1994) (7)
- Energy gradients for VT-signal migration in the CNS: studies on melanocortin receptors, mitochondrial uncoupling proteins and food intake. (2004) (7)
- Ab initio study of the protonation and the tautomerism of the 7-aminopyrazolopyrimidine molecule (1990) (7)
- GPR 55 : A therapeutic target for Parkinson ' s disease ? (2017) (7)
- Kinetics of the 5′-nucleotidase and the adenosine deaminase in subcellular fractions of rat brain (1986) (7)
- An old enzyme for current needs: adenosine deaminase and a dendritic cell vaccine for HIV (2012) (7)
- Thermodynamic analysis of agonist and antagonist binding to membrane-bound and solubilized A1 adenosine receptors. (1993) (7)
- Adenosine A2A and A3 Receptors Are Able to Interact with Each Other. A Further Piece in the Puzzle of Adenosine Receptor-Mediated Signaling (2020) (7)
- Similarities and differences upon binditng of naturally occurring Δ9-tetrahydrocannabinol-derivatives to cannabinoid CB1 and CB2 receptors. (2021) (6)
- Platforms for the identification of GPCR targets, and of orthosteric and allosteric modulators (2010) (6)
- The sigma-1 receptor as key common factor in cocaine and food seeking behaviors. (2019) (6)
- Adreno–melatonin receptor complexes control ion homeostasis and intraocular pressure ‐ their disruption contributes to hypertensive glaucoma (2020) (6)
- Quantum chemical study of the electronic and conformational characteristics of adenosine and 8-substituted derivatives: functional implications in the mechanism of reaction of adenosine deaminase. (1990) (6)
- Functional Complexes of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Receptors: Expression in Adult but Not Fetal Lung Tissue (2020) (6)
- The meaning of the Michaelis-Menten constant: Km describes a steady-state (2019) (6)
- Why have transgenic rodent models failed to successfully mimic Alzheimer’s disease. How can we develop effective drugs without them? (2019) (6)
- DIMERBOW: exploring possible GPCR dimer interfaces. (2020) (5)
- Detection, Analysis, and Quantification of GPCR Homo- and Heteroreceptor Complexes in Specific Neuronal Cell Populations Using the In Situ Proximity Ligation Assay (2018) (5)
- Dipropylcyclopentylxanthine triggers apoptosis in Jurkat T cells by a receptor-independent mechanism (1997) (5)
- Brief communication CB 2 receptor and amyloid pathology in frontal cortex of Alzheimer's disease patients (2013) (4)
- Discovery of a macromolecular complex mediating the hunger suppressive actions of cocaine: Structural and functional properties (2021) (4)
- A2A Receptor Homodimer-Disrupting Sequence Efficiently Delivered by a Protease-Resistant, Cyclic CPP Vector (2019) (4)
- Unmasking adenosine 2A receptors (A2ARs) in monkey basal ganglia output neurons using cholera toxin subunit B (CTB) (2012) (4)
- Microbiota and Other Preventive Strategies and Non-genetic Risk Factors in Parkinson’s Disease (2020) (4)
- Practical Determination of Control Coefficients in Metabolic Pathways (1990) (4)
- Transcriptional profiling of striatal neurons in response to single or concurrent activation of dopamine D2, adenosine A(2A) and metabotropic glutamate type 5 receptors: focus on beta-synuclein expression. (2012) (4)
- Characterization of Five Purine Riboswitches in Cellular and Cell-Free Expression Systems (2021) (4)
- Control analysis of transition times (1991) (4)
- Decreased levels of cGMP in CSF are associated with cognitive decline and amyloid pathology in Alzheimer ’ s disease 1 Authors : (2014) (4)
- Enzymes of the purine metabolism in rat brain microsomes (1986) (4)
- A laboratory experiment on the purification of catalase (1986) (4)
- Purification of adenosine deaminase from chicken-egg yolk by affinity column chromatography. (1990) (4)
- Adenosine metabolism in kidney slices under normoxic conditions (1990) (4)
- Interdependence between cooperativity and control coefficients. (1989) (3)
- Natural Compounds as Guides for the Discovery of Drugs Targeting G-Protein-Coupled Receptors (2020) (3)
- Cuprizone-Induced Neurotoxicity in Human Neural Cell Lines Is Mediated by a Reversible Mitochondrial Dysfunction: Relevance for Demyelination Models (2021) (3)
- Role of CD 26-adenosine deaminase interaction in T cell-mediated immunity (2005) (3)
- Effect of Endogenous Phospholipids on the [3H]R-Pia Binding to A1 Adenosine Receptors from PIG Cerebral Cortex (1991) (3)
- Reply: Does the adenosine A2A receptor stimulate the ryanodine receptor? (2007) (3)
- Adenosine‐glutamate receptor–receptor interactions in the central nervous system (2001) (3)
- L.01 Novel strategies for treatment of schizophrenia and Parkinson's disease. Focus on receptor-receptor interactions in the basal ganglia (2003) (3)
- Antioxidant Supplements versus Health Benefits of Brief/Intermittent Exposure to Potentially Toxic Physical or Chemical Agents (2021) (3)
- Identification of the Ghrelin and Cannabinoid CB2 Receptor Heteromer Functionality and Marked Upregulation in Striatal Neurons from Offspring of Mice under a High-Fat Diet (2021) (3)
- Specificity and nanomolar potency of melatonin on G-protein coupled melatonin MT1 and MT2 receptors expressed in HEK-293T human embryo kidney cells (2019) (3)
- Expression of the Adenosine A2A-A3 Receptor Heteromer in Different Brain Regions and Marked Upregulation in the Microglia of the Transgenic APPSw,Ind Alzheimer’s Disease Model (2022) (3)
- DIMERBOW: exploring possible GPCR dimer interfaces (2019) (3)
- N-Methyl-D-Aspartate Receptor Link to the MAP Kinase Pathway in Cortical and Hippocampal Neurons and Microglia Is Dependent on Calcium Sensors and Is Blocked by α-Synuclein , Tau , and Phospho-Tau in Non-transgenic and Transgenic APP Sw , Ind Mice (2018) (3)
- Adrenergic-melatonin heteroreceptor complexes are key in controlling ion homeostasis and intraocular eye pressure and their disruption contributes to hypertensive glaucoma (2019) (3)
- Expression of cannabinoid CB1R–GPR55 heteromers in neuronal subtypes of the Macaca fascicularis striatum (2020) (3)
- Targeted Metabolomics Shows That the Level of Glutamine, Kynurenine, Acyl-Carnitines and Lysophosphatidylcholines Is Significantly Increased in the Aqueous Humor of Glaucoma Patients (2022) (2)
- Adenosine A1 Receptor in Cultured Neurons from Rat Cerebral Cortex (2000) (2)
- Distribution of A1-adenosine receptors, adenosine deaminase and 5'-nucleotidase in brain and other tissues of the pig. (1990) (2)
- G-protein-coupled receptor heteromers as new targets for drug development (2013) (2)
- The Michaelis-Menten paradox: Km is not an equilibrium constant but a steady-state constant. (2019) (2)
- The Binding Mode to Orthosteric Sites and/or Exosites Underlies the Therapeutic Potential of Drugs Targeting Cannabinoid CB2 Receptors (2022) (2)
- The Michaelis-Menten paradox: Km is not an equilibrium constant but a steady-state constant. (2019) (2)
- [Purine catabolism in rat brain (author's transl)]. (1981) (2)
- 5-Hydroxytryptamine, Glutamate, and ATP: Much More Than Neurotransmitters (2021) (2)
- Similarities and differences upon binding of naturally occurring Δ 9 -tetrahydrocannabinol-derivatives to cannabinoid CB 1 and CB 2 receptors (2021) (2)
- Geoffrey Burnstock (1929–2020): the finest pharmacologist and an inspiring scientist (2021) (2)
- Potent and Subtype-Selective Dopamine D2 Receptor Biased Partial Agonists Discovered via an Ugi-Based Approach (2021) (2)
- Heteromerization of Adenosine and Dopamine Receptor Subtypes: Relevance for Neuronal Integration in Normal and Pathological States (2002) (2)
- Relationships between metabolic enzymes and the nucleoside transport. (1991) (1)
- Purification of Catalase (1989) (1)
- Rapid purification of adenosine deaminase from rat liver (1987) (1)
- Usefulness of identifying G-protein-coupled receptor dimers for diagnosis and therapy of neurodegenerative diseases and of gliomas. (2018) (1)
- Suggesting a Way to Understand the Actual Potential of Anti-Alzheimer’s Disease Drugs That Show Promise in Transgenic Mouse Models (2015) (1)
- Faculty Opinions recommendation of Adenosine A1 and A2A receptor effects on G-protein cycling in beta-adrenergic stimulated ventricular membranes. (2007) (1)
- Theoretical study of the acidic strength of amino acid side chains (1990) (1)
- Structure of G-protein-coupled receptor heteromers (2020) (1)
- Identification of Heteroreceptors Complexes and Signal Transduction Events Using Bioluminescence Resonance Energy Transfer (BRET). (2019) (1)
- IFN-g UpRegulates the A 2 B Adenosine Receptor Expression in Macrophages : A Mechanism of Macrophage Deactivation 1 (1999) (1)
- P.1.g.045 Neuroprotective effect of the monoacylglycerol lipase inhibitor JZL184 in a parkinsonian mouse model (2013) (1)
- Antagonization of OX1 Receptor Potentiates CB2 Receptor Function in Microglia from APPSw/Ind Mice Model (2022) (1)
- Heteroreceptor Complexes Implicated in Parkinson’s Disease (2017) (1)
- Ghrelin and Cannabinoid Functional Interactions Mediated by Ghrelin/CB1 Receptor Heteromers That Are Upregulated in the Striatum From Offspring of Mice Under a High-Fat Diet (2021) (1)
- Adenosine A2A‐cannabinoid CB1 receptor heteromers. Implications for the rewarding effects of cannabinoids (2007) (1)
- Theoretical study of the tautomerism of adenosine and formycin: functional implications. (1989) (1)
- Adenosine (Ado) uptake in brush-border membrane vesicles from rat kidney (BBM). (1991) (1)
- The Kinetic Component in Drug Discovery: Using the Most Basic Pharmacological Concepts to Advance in Selecting Drugs to Combat CNS Diseases (2020) (1)
- Methods to Identify the Signature of Trimers Formed by Three G Protein-Coupled Receptors or by Two G Protein-Coupled and One Ionotropic Receptor with Special Emphasis in the Functional Role in the Central Nervous System (2018) (1)
- Science plus technology to address challenges in determining the efficacy of neuroprotective/neurorestorative therapies (2021) (1)
- Enhancing cognition before clinical symptoms of dementia (2014) (1)
- Real-Time G-Protein-Coupled Receptor Imaging to Understand and Quantify Receptor Dynamics (2011) (1)
- P08 Thermodynamic differences between high-and low-affinity states of A, adenosine receptors (1992) (0)
- Cocaine Blocks Effects of Hunger Hormone, Ghrelin, Via Interaction with Neuronal Sigma-1 Receptors (2018) (0)
- 3.126 EVALUATION OF DRUGS ACTING ON CB1-A2A RECEPTOR OLIGOMERS IN RAT MODELS OF PARKINSON'S DISEASE (2012) (0)
- SOLUBLE AMYLOID-BETA ACTIVATES CHOLINE ACETYLTRANSFERASE INTERACTION BETWEEN N-METHYL ASPARTATE (NMDA) GLUTAMATE RECEPTORS AND CALCIUM SENSORS IN NEURONS: ALTERED INTERACTION AND CALCIUM-SENSOR MODULATION IN THE APP-PS1 MODEL OF ALZHEIMER’S DISEASE (2018) (0)
- Heteroreceptor Complexes Formed by Dopamine D1, Histamine H3, and N-Methyl-D-Aspartate Glutamate Receptors as Targets to Prevent Neuronal Death in Alzheimer’s Disease (2016) (0)
- NMDA receptor activation decreases adenosine A2AR function in APPSW,IND animal model of Alzheimer disease (2020) (0)
- Faculty Opinions recommendation of Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors. (2006) (0)
- P.3.f.005 A2A-adenosine, D2-dopamine and CB1-cannabinoid receptors in postmortem prefrontal cortex of schizophrenics (2008) (0)
- NMDA receptor activation decreases adenosine A 2A R function in APP SW,IND animal model of Alzheimer disease: Molecular and cell biology/protein‐protein interactions (2020) (0)
- Neuroprotective Effect of JZL184 in MPP+-Treated SH-SY5Y Cells Through CB2 Receptors (2015) (0)
- Performance Indices in Metabolic Systems: a Criterion for Evaluating Effectiveness in Metabolic Regulation (1990) (0)
- Neurochemical evidence supporting dopamine D1–D2 receptor heteromers in the striatum of the long-tailed macaque: changes following dopaminergic manipulation (2016) (0)
- Analysis and Quantification of GPCR Allosteric Receptor–Receptor Interactions Using Radioligand Binding Assays: The A2AR-D2R Heteroreceptor Complex Example (2018) (0)
- Regulation of Expression of Cannabinoid CB2 and Serotonin 5HT1A Receptor Complexes by Cannabinoids in Animal Models of Hypoxia and in Oxygen/Glucose-Deprived Neurons (2022) (0)
- Cross-communication between Gi and Gs in a G-protein-coupled receptor heterotetramer guided by a receptor C-terminal domain (2018) (0)
- Novel Modulator of T Cell Activation Glutamate Released by Dendritic Cells as a (2006) (0)
- NeurophysiologyandPharmacology,PsychiatryCentreofExcellenceforDrugDiscovery,GlaxoSmithKlinePharmaceuticals, Harlow,EssexCM195AW,UnitedKingdom (2007) (0)
- An improved method for the preparation of rat brain microsomes. (1986) (0)
- INTERACTION BETWEEN N-METHYL ASPARTATE (NMDA) GLUTAMATE RECEPTORS AND CALCIUM SENSORS IN NEURONS: ALTERED INTERACTION AND CALCIUM-SENSOR MODULATION IN THE APP-PS1 MODEL OF ALZHEIMER’S DISEASE (2018) (0)
- ArticleAdenosine A (2020) (0)
- NEUROPROTECTIVE EFFECT OF CANNABINOID RECEPTORS IN NEUROINFLAMATION (2017) (0)
- Response to Drs. Straub and Jessop (2008) (0)
- Mandarin Translations (2010) (0)
- Transport de nucleòsids (1995) (0)
- Humans and Caffeine—A Very Long Relationship (2017) (0)
- ADENOSINE A2A RECEPTOR ACTIVATION ATTENUATES NMDA RECEPTOR FUNCTION IN ALZHEIMER DISEASE (2019) (0)
- Application of Progress Curve Analysis to Enzyme Kinetic Studies Using Radioactive Measurements (1991) (0)
- Novel Interactions between Mas and Angiotensin Receptors and Their Functionality Modulatory Role for the Brain RAS (2021) (0)
- Smart cell-surface receptors: On the 2012 Nobel Prize in Chemistry, awarded to Robert J. Lefkowitz and Brian K. Kobilka (2013) (0)
- RESEARCH ARTICLE Synthesis and Evaluation of 13 N-Labelled Azo Compounds for β-Amyloid Imaging in Mice (2013) (0)
- A1R–A2AR heteromers coupled to Gs and Gi/0 proteins modulate GABA transport into astrocytes (2013) (0)
- Amyloid Beta Precursor Protein: Proper Credit for the Basic Biochemical Properties of the Most Studied Protein in the 21 st Century * (2014) (0)
- Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with Gi and Gs (2016) (0)
- SIMCODE: A program for simulating point mutations in genomic DNA (1985) (0)
- Effect of σ 1 receptor ligands on σ 1 -D 2 receptor heteromer. (2013) (0)
- Stronger Dopamine D1 Receptor-Mediated Neurotransmission in Dyskinesia (2014) (0)
- Interaction of trans-acting factors with the proximal promoter of the mouse alpha-fetoprotein gene. (1992) (0)
- A1 Adenosine receptors can occur manifesting two kinetic components of 8-cyclopentyl-1,3-[3H]dipropylxanthine ([3H]DPCPX) binding (1994) (0)
- Angiotensin AT1 and AT2 receptors heteromer expression in microglia correlates with Parkinson’s disease progression in the hemilesioned rat model of the disease (2020) (0)
- Computer-based learning of cooperativity and allostery (1985) (0)
- Round table discussion: Glia is centrally involved in the pathogenic process of degenerative diseases and should be a therapeutic target (Session 39- Neurodegenerative Diseases) (2019) (0)
- Multiple ligands applied to dopamine and adenosine receptors (2007) (0)
- Cholesterol in autism spectrum disorders (2021) (0)
- F1000Prime recommendation of Discovery of endogenous catecholamines in lymphocytes and evidence for catecholamine regulation of lymphocyte function via an autocrine loop. (2007) (0)
- Expression and Impact of Adenosine A3 Receptors on Calcium Homeostasis in Human Right Atrium (2023) (0)
- Interaction of trans-acting factors with the proximal promoter of the mouse α-fetoprotein gene (1992) (0)
- Adenosine Receptors as a Paradigm to Identify Dimer/Oligomers of G-Protein-Coupled Receptors and as Targets in Parkinson’s Disease and Schizophrenia (2018) (0)
- STRIATUM RECEPTOR INTERACTIONS IN THE D3 - FOR A ROLE OF SYNERGISTIC D1 Receptor Heteromers: INDICATIONS 3 D - 1 Identification of Dopamine D Mechanisms of Signal Transduction: (2014) (0)
- FOR A ROLE OF SYNERGISTIC D 1 Receptor Heteromers : INDICATIONS 3 D − 1 Identification of Dopamine D Mechanisms of Signal Transduction : (2008) (0)
- Author ' s personal copy The emergence of neurotransmitters as immune modulators (2007) (0)
- Cytochemical demonstration of 5′-nucleotidase in rat brain synaptosomes (1987) (0)
- Adenosine Receptors as a Paradigm to Identify Dimer/Oligomers of G-Protein-Coupled Receptors and as Targets in Parkinson’s Disease and Schizophrenia (2018) (0)
- Front cover: Health benefits of methylxanthines in neurodegenerative diseases (2017) (0)
- Introductory and Basic aspects (2008) (0)
- Protein factors involved in the expression of the alpha-fetoprotein gene. (1991) (0)
- Protein factors involved in the expression of the α-fetoprotein gene (1991) (0)
- Dipropylcyclopentylxanthine triggers apoptosis in cells from patients with myeloid leukaemia (2004) (0)
- Methamphetamine Blocks Adenosine A2A Receptor Activation via Sigma 1 and Cannabinoid CB1 Receptors (2021) (0)
- Identification of a Tool Compound to Study the Mechanisms of Functional Selectivity between D2 and D3 Dopamine Receptors (2018) (0)
- Orexin A/Hypocretin Modulates Leptin Receptor-Mediated Signaling by Allosteric Modulations Mediated by the Ghrelin GHS-R1A Receptor in Hypothalamic Neurons (2017) (0)
- Hints on the Lateralization of Dopamine Binding to D1 Receptors in Rat Striatum (2015) (0)
- Chapter 4.3. Pharmacology (2008) (0)
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