Rajini Rao
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Indian Physiologist
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Rajini Raobiology Degrees
Biology
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#17392
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#2730
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Physiology
#502
World Rank
#750
Historical Rank
#64
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Biology
Rajini Rao's Degrees
- Bachelors Biology Delhi University
- Masters Physiology Delhi University
- PhD Physiology Delhi University
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Why Is Rajini Rao Influential?
(Suggest an Edit or Addition)According to Wikipedia, Rajini Rao is an American physiologist who is a professor at Johns Hopkins University School of Medicine. Rao is also the director of the Graduate Program in Cellular and Molecular Medicine and is the principal investigator of the Rao Lab. She is an elected fellow of the American Association for the Advancement of Science, Rao discovers novel ion channels and explores their roles in human health and disease. The Rao Lab identified the oncogenic role of SPCA2 in breast cancer through an aberrant method of signalling to calcium channels.
Rajini Rao's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Evolutionary origins of eukaryotic sodium/proton exchangers. (2005) (512)
- The yeast endosomal Na+K+/H+ exchanger Nhx1 regulates cellular pH to control vesicle trafficking. (2005) (319)
- Intracellular Sequestration of Sodium by a Novel Na+/H+ Exchanger in Yeast Is Enhanced by Mutations in the Plasma Membrane H+-ATPase (1997) (271)
- Store-Independent Activation of Orai1 by SPCA2 in Mammary Tumors (2010) (257)
- PMR1, a Ca2+-ATPase in Yeast Golgi, Has Properties Distinct from Sarco/endoplasmic Reticulum and Plasma Membrane Calcium Pumps* (1997) (256)
- Mechanism of Antifungal Activity of Terpenoid Phenols Resembles Calcium Stress and Inhibition of the TOR Pathway (2010) (236)
- Novel Localization of a Na+/H+ Exchanger in a Late Endosomal Compartment of Yeast (1998) (222)
- Requirement for Ergosterol in V-ATPase Function Underlies Antifungal Activity of Azole Drugs (2010) (191)
- Cod1p/Spf1p is a P-type ATPase involved in ER function and Ca2+ homeostasis (2002) (174)
- Antifungal Activity of Amiodarone Is Mediated by Disruption of Calcium Homeostasis* (2003) (164)
- Human Na(+)/H(+) exchanger isoform 6 is found in recycling endosomes of cells, not in mitochondria. (2002) (164)
- Functional Expression in Yeast of the Human Secretory Pathway Ca2+, Mn2+-ATPase Defective in Hailey-Hailey Disease* (2002) (146)
- Expression of the yeast plasma membrane [H+]ATPase in secretory vesicles. A new strategy for directed mutagenesis. (1991) (139)
- Inhibition of Sodium/Proton Exchange by a Rab-GTPase-activating Protein Regulates Endosomal Traffic in Yeast* (2004) (123)
- A Novel Isoform of the Secretory Pathway Ca2+,Mn2+-ATPase, hSPCA2, Has Unusual Properties and Is Expressed in the Brain* (2005) (117)
- The yeast endosomal Na+/H+ exchanger, Nhx1, confers osmotolerance following acute hypertonic shock. (1999) (115)
- Manganese Selectivity of Pmr1, the Yeast Secretory Pathway Ion Pump, Is Defined by Residue Gln783 in Transmembrane Segment 6 (2000) (103)
- Functional expression of heterologous proteins in yeast: insights into Ca2+ signaling and Ca2+-transporting ATPases. (2004) (99)
- Amyloid clearance defect in ApoE4 astrocytes is reversed by epigenetic correction of endosomal pH (2018) (97)
- FUNCTIONAL EVALUATION OF AUTISM-ASSOCIATED MUTATIONS IN NHE9 (2013) (87)
- A human Na+/H+ antiporter sharing evolutionary origins with bacterial NhaA may be a candidate gene for essential hypertension (2007) (86)
- Genome-Wide Analysis Reveals the Vacuolar pH-Stat of Saccharomyces cerevisiae (2011) (84)
- An inside job: how endosomal Na+/H+ exchangers link to autism and neurological disease (2014) (82)
- Localization of plasma membrane and secretory calcium pumps in the mammary gland. (2008) (81)
- A Leak Pathway for Luminal Protons in Endosomes Drives Oncogenic Signaling in Glioblastoma (2015) (80)
- Selective inhibition of HER2-positive breast cancer cells by the HIV protease inhibitor nelfinavir. (2012) (79)
- Plant-Specific Cation/H+ Exchanger 17 and Its Homologs Are Endomembrane K+ Transporters with Roles in Protein Sorting* (2011) (77)
- Membrane Hyperpolarization Drives Cation Influx and Fungicidal Activity of Amiodarone* (2009) (75)
- Cellular calcium dynamics in lactation and breast cancer: from physiology to pathology. (2014) (74)
- Mechanism of the Synergistic Effect of Amiodarone and Fluconazole in Candida albicans (2010) (73)
- Transcriptional regulation by glucose of the yeast PMA1 gene encoding the plasma membrane H+‐ATPase (1993) (72)
- SPCA2 Regulates Orai1 Trafficking and Store Independent Ca2+ Entry in a Model of Lactation (2013) (66)
- Direct Comparison of Manganese Detoxification/Efflux Proteins and Molecular Characterization of ZnT10 Protein as a Manganese Transporter* (2016) (65)
- Phenotypic Screening of Mutations in Pmr1, the Yeast Secretory Pathway Ca2+/Mn2+-ATPase, Reveals Residues Critical for Ion Selectivity and Transport* (2000) (65)
- Induction of vacuolar CaZ+‐ATPase and H+/Ca 2+ exchange activity in yeast mutants lacking Pmrl, the Golgi Ca2+‐ATPase (1999) (62)
- Vestibular Hair Bundles Control pH with (Na+, K+)/H+ Exchangers NHE6 and NHE9 (2006) (59)
- An N-terminal EF hand-like motif modulates ion transport by Pmr1, the yeast Golgi Ca(2+)/Mn(2+)-ATPase. (1999) (58)
- Calcium-ATPases: Gene disorders and dysregulation in cancer. (2016) (56)
- Beyond ergosterol: linking pH to antifungal mechanisms. (2010) (54)
- A phenomics approach in yeast links proton and calcium pump function in the Golgi. (2007) (50)
- Replacement of the invariant lysine 77 by arginine in yeast iso-1-cytochrome c results in enhanced and normal activities in vitro and in vivo. (1987) (49)
- Vesicular distribution of Secretory Pathway Ca2+-ATPase isoform 1 and a role in manganese detoxification in liver-derived polarized cells (2011) (48)
- Model-guided mutagenesis drives functional studies of human NHA2, implicated in hypertension. (2010) (47)
- The Na+/H+ Exchanger NHE6 Modulates Endosomal pH to Control Processing of Amyloid Precursor Protein in a Cell Culture Model of Alzheimer Disease* (2015) (47)
- Fungicidal activity of amiodarone is tightly coupled to calcium influx. (2008) (43)
- Directed mutagenesis of the strongly conserved lysine 175 in the proposed nucleotide-binding domain of alpha-subunit from Escherichia coli F1-ATPase. (1988) (42)
- Essential Role for Vacuolar Acidification in Candida albicans Virulence* (2013) (42)
- Trinitrophenyl-ATP and -ADP bind to a single nucleotide site on isolated beta-subunit of Escherichia coli F1-ATPase. In vitro assembly of F1-subunits requires occupancy of the nucleotide-binding site on beta-subunit by nucleoside triphosphate. (1988) (41)
- Global Disruption of Cell Cycle Progression and Nutrient Response by the Antifungal Agent Amiodarone* (2007) (39)
- Substitutions of Aspartate 378 in the Phosphorylation Domain of the Yeast PMA1 H+-ATPase Disrupt Protein Folding and Biogenesis* (1998) (38)
- The yeast Na+/H+ exchanger Nhx1 is an N-linked glycoprotein. Topological implications. (2001) (38)
- Mutational analysis of the intramembranous H10 loop of yeast Nhx1 reveals a critical role in ion homoeostasis and vesicle trafficking. (2006) (37)
- Packing Interactions between Transmembrane Helices Alter Ion Selectivity of the Yeast Golgi Ca2+/Mn2+-ATPase PMR1* (2003) (37)
- Cod 1 p / Spf 1 p is a P-type ATPase involved in ER function and Ca 2 homeostasis (2002) (35)
- Mutagenesis of conserved residues in the phosphorylation domain of the yeast plasma membrane H(+)-ATPase. Effects on structure and function. (1993) (33)
- Does the proteome encode organellar pH? (2006) (30)
- Transmembrane Segments of the P‐Type Cation‐Transporting ATPases A Comparative Study a (1989) (29)
- Unconventional Chemiosmotic Coupling of NHA2, a Mammalian Na+/H+ Antiporter, to a Plasma Membrane H+ Gradient* (2012) (29)
- Secretory pathway Ca2+‐ATPases promote in vitro microcalcifications in breast cancer cells (2017) (28)
- Subtype specific targeting of calcium signaling in breast cancer. (2019) (27)
- The properties of hybrid F1-ATPase enzymes suggest that a cyclical catalytic mechanism involving three catalytic sites occurs. (1987) (27)
- Emerging links between endosomal pH and cancer (2020) (27)
- Dysregulation of Ion Homeostasis by Antifungal Agents (2012) (25)
- Pyridoxal 5'-diphospho-5'-adenosine binds at a single site on isolated alpha-subunit from Escherichia coli F1-ATPase and specifically reacts with lysine 201. (1988) (24)
- Expression of Hailey-Hailey disease mutations in yeast. (2004) (23)
- Histone deacetylase–mediated regulation of endolysosomal pH (2018) (22)
- Structure and Function of the Yeast Plasma‐Membrane H+‐ATPase a (1992) (21)
- The defective proton-ATPase of uncA mutants of Escherichia coli: ATP-binding and ATP-induced conformational change in mutant alpha-subunits. (1987) (20)
- Endosomal Na+ (K+)/H+ Exchanger Nhx1/Vps44 Functions Independently and Downstream of Multivesicular Body Formation* (2011) (20)
- A spoke in the wheel: Calcium spikes disrupt yeast cell cycle (2008) (20)
- Plasma-Membrane and Related ATPases (1996) (20)
- Induction of vacuolar Ca 2-ATPase and H / Ca 2 exchange activity in yeast mutants lacking Pmr 1 , the Golgi Ca 2-ATPase (1999) (19)
- Mutagenesis of the yeast plasma membrane H(+)-ATPase. A novel expression system. (1992) (17)
- New insights into store-independent Ca2+ entry: secretory pathway calcium ATPase 2 in normal physiology and cancer (2013) (17)
- A Ca2+-ATPase Regulates E-cadherin Biogenesis and Epithelial–Mesenchymal Transition in Breast Cancer Cells (2019) (16)
- The V-ATPase as a target for antifungal drugs. (2012) (15)
- NHA2 is expressed in distal nephron and regulated by dietary sodium (2017) (14)
- The Yeast Na 1 /H 1 Exchanger Nhx1 Is an N-Linked Glycoprotein (2001) (12)
- The Yeast Na+/H+ Exchanger Nhx1 Is anN-Linked Glycoprotein (2001) (10)
- NHA2 promotes cyst development in an in vitro model of polycystic kidney disease (2018) (9)
- Applying knowledge of autism to brain cancer management: what do we know? (2015) (9)
- Functional analysis of Na+/H+ exchanger 9 variants identified in patients with autism and epilepsy (2017) (8)
- 3 – The Nucleotide-binding Site of the Plasma-membrane H+-ATPase of Neurospora crassa: A Comparison with other P-type ATPases (1989) (6)
- Epigenetic Modulation of SPCA2 Reverses Epithelial to Mesenchymal Transition in Breast Cancer Cells (2020) (6)
- Secretory pathway Ca2+-ATPase SPCA2 regulates mitochondrial respiration and DNA damage response through store-independent calcium entry (2022) (4)
- Abstract 1125: Secretory pathway calcium ATPase-2 (SPCA2) regulates metastasis by suppressing mesenchymal markers in triple negative breast cancer cell lines (2019) (3)
- The Amyloid Clearance Defect in ApoE4 Astrocytes is Corrected by Epigenetic Restoration of NHE6 (2018) (3)
- Endosomal Acid-Base Homeostasis in Neurodegenerative Diseases. (2020) (3)
- Fungicidal activityofamiodarone is tightlycoupled to calcium in £ ux (2008) (2)
- A Ca2+-ATPase Regulates E-cadherin Biogenesis and Epithelial-Mesenchymal Transition in Breast Cancer Cells (2018) (2)
- Structural features of the yeast plasma-membrane H(+)-ATPase. (1994) (2)
- Na+/H+ exchanger NHE9 affects tumor progression of human glioblastomas by altering endosomal pH (893.34) (2014) (2)
- Store Independent Ca2+ Entry Regulates the DNA Damage Response in Breast Cancer Cells (2020) (2)
- brain human functionally distinct regions of the normal aged Gene expression profiles in anatomically and (2015) (1)
- Ca2+-ATPase Genes and Related Diseases (2003) (1)
- Faculty Opinions recommendation of PAC, an evolutionarily conserved membrane protein, is a proton-activated chloride channel. (2019) (0)
- NHA2 is expressed in distal nephron and regulated by dietary sodium (2016) (0)
- Emerging links between endosomal pH and cancer (2020) (0)
- Interaction and Regulation of Calcium Homeostasis by TRPV Channels and SPCA2 in Breast Cancer (2011) (0)
- Virulence Candida albicans Essential Role for Vacuolar Acidification in Membrane Biology : (2013) (0)
- Dynamic function of secretory pathway Ca2+‐ATPase 2 (SPCA2) and transient receptor potential (TRP) channels in breast cancer (2011) (0)
- Interactions Between Secretory Pathway Ca2+-ATPase 2 with TRP and Orai Channels Mediate Store Independent Ca2+ Entry in Lactation (2012) (0)
- A Moonlighting Role for SPCA2 in E-cadherin Biogenesis and Suppression of Epithelial-Mesenchymal Transition (2018) (0)
- Functional Evaluation of NHE6 Mutation Associated with Syndromic Autism and Tau Deposition (2014) (0)
- Culture Model of Alzheimer Disease Amyloid Precursor Protein in a Cell Endosomal pH to Control Processing of Exchanger NHE 6 Modulates + / H + The (2015) (0)
- Role of Endosomal Sodium/Hydrogen Exchangers NHE6 and NHE9 in a Neurobiological Model of Disease (2012) (0)
- Organellar calcium pumps of the golgi and ER: from yeast to human (2007) (0)
- P2-03-04: Novel Pathways Underlying the Initiation and Transition of DCIS to IDC of HER2−Overexpressing Breast Cancer Model. (2011) (0)
- Functional Evaluation of Autism Associated Mutations in Slc9A9 (NHE9) (2013) (0)
- Secretory pathway Ca2+_ATPase isoforms in mouse lactation and in human breast cancer (2007) (0)
- The Na+/H+ Exchanger NHE6 Links Endosomal pH to Amyloid Pathologies in Alzheimer's Disease (2015) (0)
- Abstract 448: The novel role of ecdysoneless (ECD) in maintain ER Ca2+ homeostasis (2018) (0)
- Calcium Dynamics and Homeostasis in Breast Cancer Oncogenesis (2015) (0)
- A conserved mechanism for regulation of endo-lysosomal pH by histone deacetylases (2018) (0)
- Milk on the Moo've. (2021) (0)
- NHA2 promotes cyst development in an in vitro model of polycystic kidney disease (2018) (0)
- Abstract 5276: Secretory pathway calcium ATPase 2 (SPCA2) promotes cell survival and chemoresistance in receptor positive breast cancer cells (2020) (0)
- Packing Interactions in the Golgi Calcium Pump 35294 (2003) (0)
- and Rajini Stress and Inhibition of the TOR Pathway Terpenoid Phenols Resembles Calcium Mechanism of Antifungal Activity of (2010) (0)
- Packing Interactions between Transmembrane Helices Alter Ion Selectivity of the Yeast Golgi Ca 2 (cid:1) /Mn 2 (cid:1) -ATPase PMR1* (2003) (0)
- Functional Evaluation of Autism-Related Mutations in the Na+ (k+)/ H+ Exchanger NHE9 (2011) (0)
- The calcium connection (2010) (0)
- Secretory Pathway Calcium ATPases in Breast Cancer (2016) (0)
- Calcium transport in the mammary gland: A role for secretory pathway calcium ATPase 2 (SPCA2) in normal physiology and breast cancer (2007) (0)
- Model-Structure, Mutagenesis and Functional Characteristics of the Human Transporter, NHA2 (2010) (0)
- Selective inhibition of H er 2-P ositive Breast cancer cells b y the HiV P rotease inhibitor Nelf inavir (2012) (0)
- from physiology to pathology Cellular calcium dynamics in lactation and breast cancer (2016) (0)
- The endosomal pH regulator NHE9 is a driver of stemness in glioblastoma (2021) (0)
- An unconventional role in store-independent constitutive calcium signaling by the secretory pathway calcium - atpases in mammary tumors (2010) (0)
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