Ralph F. Hirschmann
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American biochemist
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Biology
Why Is Ralph F. Hirschmann Influential?
(Suggest an Edit or Addition)According to Wikipedia, Ralph Franz Hirschmann was a German American chemist who led a team that was responsible for the first organic synthesis of an enzyme, a ribonuclease. Early life and education Born on May 6, 1922, in Fürth, he emigrated from Nazi Germany in 1936 and settled with his family in Kansas City, Missouri. He became a naturalized citizen of the United States in 1944. After graduating from Oberlin College in 1943, he served in the United States Army for three years in the Pacific Theater of Operations. Following the completion of his military service, Hirschmann attended the University of Wisconsin–Madison, receiving his Doctor of Philosophy in organic chemistry in 1950.
Ralph F. Hirschmann's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- A new class of angiotensin-converting enzyme inhibitors (1980) (659)
- A potent cyclic hexapeptide analogue of somatostatin (1981) (356)
- Peptide synthesis catalyzed by an antibody containing a binding site for variable amino acids. (1994) (308)
- Acetamidomethyl. A novel thiol protecting group for cysteine. (1972) (253)
- De novo design and synthesis of somatostatin non-peptide peptidomimetics utilizing beta-D-glucose as a novel scaffolding (1993) (198)
- Nonpeptidal peptidomimetics with a β-D-glucose scaffolding. A partial somatostatin agonist bearing a close structural relationship to a potent, selective substance P antagonist (1992) (192)
- Medicinal Chemistry in the Golden Age of Biology: Lessons from Steroid and Peptide Research (1991) (157)
- Conformationally restricted bicyclic analogs of somatostatin. (1978) (114)
- Azide and Cyanide Displacements via Hypervalent Silicate Intermediates. (1999) (107)
- Studies on the total synthesis of an enzyme. V. The preparation of enzymatically active material. (1969) (100)
- Design, synthesis, and crystal structure of a pyrrolinone-based peptidomimetic possessing the conformation of a .beta.-strand: potential application to the design of novel inhibitors of proteolytic enzymes (1992) (96)
- The Controlled Synthesis of Peptides in Aqueous Medium. I. The Use of α-Amino Acid N-Carboxyanhydrides (1966) (87)
- The controlled synthesis of peptides in aqueous medium. 3. Use of Leuchs' anhydrides in the synthesis of dipeptides. Mechanism and control of side reactions. (1967) (84)
- Pyrrolinone-based peptidomimetics. "Let the enzyme or receptor be the judge". (2011) (77)
- De Novo Design, Synthesis, and X-ray Crystal Structures of Pyrrolinone-Based .beta.-Strand Peptidomimetics (1994) (76)
- Modulation of receptor and receptor subtype affinities using diastereomeric and enantiomeric monosaccharide scaffolds as a means to structural and biological diversity. A new route to ether synthesis. (1998) (74)
- Inferences about the conformation of somatostatin at a biologic receptor based on NMR studies (1978) (70)
- Heterocyclic analogues of the antihypertensive beta-adrenergic blocking agent (S)-2-[3-(ter-butylamino)-2-hydroxypropoxy]-3-cyanopyridine. (1980) (67)
- Controlled synthesis of peptides in aqueous medium. VIII. Preparation and use of novel .alpha.-amino acid N-carboxyanhydrides (1971) (67)
- The Rearrangement of the Steroid C/D Rings1 (1954) (67)
- Peptide bond formation via catalytic antibodies: Synthesis of a novel phosphonate diester hapten (1994) (66)
- Synthesis and Structure of Steroidal Pregn-4-eno- and 5α-Pregnano [3,2-c]pyrazoles. A Novel Class of Potent Anti-Inflammatory Steroids (1964) (65)
- Design and synthesis of peptidomimetic inhibitors of HIV-1 protease and renin. Evidence for improved transport. (1994) (62)
- The first design and synthesis of a steroidal peptidomimetic. The potential value of peptidomimetics in elucidating the bioactive conformation of peptide ligands (1992) (61)
- Phosphonate Diester and Phosphonamide Synthesis. Reaction Coordinate Analysis by 31P NMR Spectroscopy: Identification of Pyrophosphonate Anhydrides and Highly Reactive Phosphonylammonium Salts1 (1997) (59)
- Studies on the total synthesis of an enzyme. I. Objective and strategy. (1969) (56)
- Nonreducible cyclic analogues of somatostatin (1976) (52)
- The beta-D-glucose scaffold as a beta-turn mimetic. (2009) (51)
- An orally bioavailable pyrrolinone inhibitor of HIV-1 protease: computational analysis and X-ray crystal structure of the enzyme complex. (1997) (50)
- Synthesis and Structure of Steroidal 4-Pregneno [3,2-c]Pyrazoles. A Novel Class of Potent Anti-Inflammatory Steroids (1963) (50)
- Pyrrolinone-Based HIV Protease Inhibitors. Design, Synthesis, and Antiviral Activity: Evidence for Improved Transport (1995) (47)
- Inhibitors of gastric acid secretion: 3,4-diamino-1,2,5-thiadiazole 1-oxides and 1,1-dioxides as urea equivalents in a series of histamine H2-receptor antagonists. (1982) (46)
- The synthesis of peptides in aqueous medium. IV. A novel protecting group for cysteine. (1968) (45)
- Synthesis of potent cyclic hexapeptide NK-1 antagonists. Use of a minilibrary in transforming a peptidal somatostatin receptor ligand into an NK-1 receptor ligand via a polyvalent peptidomimetic. (1996) (43)
- The synthesis of peptides in aqueous medium. VII. The preparation and use of 2,5-thiazolidinediones in peptide synthesis. (1971) (42)
- Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors. (2003) (42)
- Synthesis and antihypertensive activity of some ester progenitors of methyldopa. (1978) (41)
- Design and synthesis of novel scaffolds for drug discovery: hybrids of beta-D-glucose with 1,2,3,4-tetrahydrobenzo[e][1,4]diazepin-5-one, the corresponding 1-oxazepine, and 2- and 4-pyridyldiazepines. (2001) (41)
- The cortisone era: aspects of its impact. Some contributions of the Merck Laboratories (1992) (40)
- Novel ligands lacking a positive charge for the δ- and μ-opioid receptors (2000) (39)
- Effects of heterocyclic aromatic substituents on binding affinities at two distinct sites of somatostatin receptors. Correlation with the electrostatic potential of the substituents. (2003) (39)
- The Reaction of Epoxides with Anhydrous Hydrogen Fluoride in the Presence of Organic Bases. The Preparation of 9α-Fluoro-4-pregnene-11β,17α,21-Triol 3,20-Dione 21-Acetate and Its 1-Dehydro Analog (1956) (39)
- Purification and characterization of human liver glycolate oxidase. Molecular weight, subunit, and kinetic properties. (1979) (38)
- Synthesis of thyrotropin-releasing hormone analogues with selective central nervous system effects. (1981) (38)
- Design and Synthesis of a Competent Pyrrolinone−Peptide Hybrid Ligand for the Class II Major Histocompatibility Complex Protein HLA-DR1 (1999) (35)
- Isonicotinyloxycarbonyl, a novel amino protecting group for peptide synthesis. (1977) (35)
- Synthesis of peptides in aqueous medium. V. Preparation and use of 2,5-thiazolidinediones (NTA's). Use of the 13C-H nuclear magnetic resonance signal as internal standard for quantitative studies. (1968) (35)
- 16-Methylated Steroids. IV. 6,16α-Dimethyl-▵6-Hydrocortisone and Related Compounds (1963) (34)
- On the low energy solution conformation of somatostatin. (1981) (33)
- Studies on the total synthesis of an enzyme. II. Synthesis of a protected tetratetracontapeptide corresponding to the 21-64 sequence of ribonuclease A. (1969) (33)
- The Synthesis of Vitamin K11 (1954) (33)
- REARRANGEMENT OF THE STEROID C/D RINGS. SYNTHESIS OF AN 11-KETO-Δ13(17a)-C-NOR/D-HOMO-STEROID (1953) (32)
- The versatile steroid nucleus: Design and synthesis of a peptidomimetic employing this novel scaffold. (1993) (32)
- Design and synthesis of a tetrahydropyran-based inhibitor of mammalian ribonucleotide reductase. (1998) (30)
- Synthesis of a proposed growth hormone releasing factor. (1971) (30)
- Lactam restriction of peptide conformation in cyclic hexapeptides which alter rumen fermentation. (2009) (29)
- Development of an efficient, regio- and stereoselective route to libraries based on the beta-D-glucose scaffold. (2000) (28)
- A NEW BIOLOGICALLY POTENT STEROID: 1-DEHYDRO-9α-FLUOROHYDROCORTISONE ACETATE (1955) (28)
- Symbiotic approach to drug design: antihypertensive beta-adrenergic blocking agents. (1979) (28)
- The microbial 1-dehydrogenation of some delta4-3 ketosteroids. (1955) (26)
- Investigations of an Antibody Ligase (1997) (25)
- Total synthesis of an enzyme. IV. Factors affecting the conversion of protected S-protein to ribonuclease S' (1969) (25)
- Novel chimeric scaffolds to extend the exploration of receptor space: hybrid beta-D-glucose-benzoheterodiazepine structures for broad screening. Effect of amide alkylation on the course of cyclization reactions. (2004) (24)
- An effective synthesis of scalemic 3,5,5-trisubstituted pyrrolin-4-ones (1993) (24)
- Synthesis and Properties of 4-Methyl-2-oxo-1,2-benzopyran-7-yl β-D-Galactoside (Galactoside of 4-Methylumbelliferone) (1962) (23)
- beta-Adrenergic blocking agents with acute antihypertensive activity. (1979) (23)
- Somatostatin analogs which define the role of the lysine-9 amino group. (2009) (22)
- Photochemistry of Biologically Important Transition Metal Complexes. I. Cyanocobalamin and Related Corrin Complexes of Rhodium(III) (1976) (22)
- CONFIGURATION AT C12 OF 12-HYDROXYLATED SAPOGENINS. REARRANGEMENT OF THE STEROID C/D RINGS (1952) (22)
- The Partial Synthesis of 12α-Methyl-11-dehydrocorticosterone (1960) (22)
- Synthesis of a substance P antagonist with a somatostatin scaffold: factors affecting agonism/antagonism at GPCRs and the role of pseudosymmetry. (2000) (21)
- Dihydrofolate reductase: the amino acid sequence of the enzyme from a methotrexate-resistant mutant of Escherichia coli. (1978) (21)
- Molecular modeling, synthesis, and structures of N-methylated 3,5-linked pyrrolin-4-ones toward the creation of a privileged nonpeptide scaffold. (1999) (20)
- Some novel, acid-labile amine protecting groups (1977) (20)
- Piperazinylpyrazines with central serotoninmimetic activity. (1978) (19)
- Design and synthesis of nonpeptide peptidomimetic inhibitors of renin (1995) (19)
- Design, Synthesis, and Solution Structure of a Pyrrolinone-Based β-Turn Peptidomimetic (2000) (19)
- The design and synthesis of 2,5-linked pyrrolinones. A potential non-peptide peptidomimetic scaffold. (1996) (19)
- SYNTHESIS OF PREGN-4-ENO(3,2-C)PYRAZOLES RELATED TO 9-ALPHA-FLUORO-16-ALPHA-METHYLCORTISOL. (1964) (19)
- PHOSPHONYLTRIETHYLAMMONIUM SALTS : NOVEL REACTIVE SPECIES FOR THE SYNTHESIS OF PHOSPHONATE ESTERS AND PHOSPHONONAMIDES (1995) (18)
- First generation design, synthesis, and evaluation of azepine-based cryptophycin analogues. (2001) (18)
- DESIGN, SYNTHESIS, AND EVALUATION OF A PYRROLINONE-PEPTIDE HYBRID LIGAND FOR THE CLASS II MHC PROTEIN HLA-DR1 (1998) (17)
- Design and synthesis of sulfur-free cyclic hexapeptides which contain the RGD sequence and bind to the fibrinogen GP IIb/IIIa receptor. A conformation-based correlation between propensity for imide formation and receptor affinity. (2009) (17)
- Design, synthesis, and evaluation of azepine-based cryptophycin mimetics (2003) (17)
- A General Synthesis of 4,5-Unsaturated 2-Oxasteroids. A Synthesis of 2-Oxacortisol (1962) (17)
- An Approach to an Improved Antiinflammatory Steroid. The Synthesis of 11β,17-Dihydroxy-3,20-dione-1,4-pregnadien-21-yl 2-Acetamido-2-deoxy-β-D-glucopyranoside (1964) (17)
- Synthesis and stereospecific antipsychotic activity of (-)-1-cyclopropylmethyl-4-(3-trifluoromethylthio-5H-dibenzo[a,d]cyclohepten-5-ylidene)piperidine. (1977) (17)
- A CONTRIBUTION TO THE CHEMISTRY OF STEROID 17,21-OXIDES (1956) (16)
- Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors possessing augmented P2' side chains. (2006) (16)
- Synthesis of peptides in aqueous medium. VI. Synthesis of an unsymmetrical cystine peptide fragment of insulin (1969) (16)
- De Novo Design and Synthesis of Somatostatin Non‐Peptide Peptidomimetics Utilizing β‐D‐Glucose as a Novel Scaffolding. (1994) (15)
- An approach to peripheral vasodilator-beta-adrenergic blocking agents. (1977) (15)
- Design and synthesis of potent cystine-free cyclic hexapeptide agonists at the human urotensin receptor. (2006) (15)
- Titanium(III) as a selective reducing agent for nitroarginyl peptides: synthesis of arginine vasotocin (1978) (15)
- Design, synthesis, and binding affinities of pyrrolinone-based somatostatin mimetics. (2005) (15)
- Inhibitors of gastric acid secretion: antisecretory 2-pyridylurea derivatives. (1983) (15)
- The synthesis of an enzyme. (1970) (15)
- A second-generation synthesis of polypyrrolinone nonpeptidomimetics: prelude to the synthesis of polypyrrolinones on solid support. (2000) (15)
- The Conversion of Hecogenin to ▵7,9(11)-22-isoallospirostadiene-3β-ol1 (1953) (14)
- A second-generation synthesis of scalemic 3,5,5-trisubstituted pyrrolin-4-ones: Incorporation of functionalized amino acid side-chains (1997) (14)
- Intramolecular hydrogen-bond participation in phosphonylammonium salt formation. (2000) (14)
- Design, Synthesis, and Crystal Structure of a Pyrrolinone-Based Peptidomimetic Possessing the Conformation of a β-Strand: Potential Application to the Design of Novel Inhibitors of Proteolytic Enzymes (1993) (14)
- A Partial Synthesis of 11β,17α,21-Trihydroxy-A-nor-3(5)-pregnene-2,20-dione, an A-Nor Homolog of Hydrocortisone (1959) (14)
- Catechol: A minimal scaffold for non-peptide peptidomimetics of the i + 1 and i + 2 positions of the beta-turn of somatostatin. (2006) (13)
- Configurational Relationship of 11,12-Oxygenated Sapogenins. Rearrangement to the [3.3.0]Bicycloöctane System1 (1955) (13)
- A New Route to 2-Amino-2-deoxy-β-D-glucosides (1966) (13)
- Transport Characteristics of Peptidomimetics. Effect of the Pyrrolinone Bioisostere on Transport Across Caco-2 Cell Monolayers (1998) (13)
- A versatile, efficient synthesis of (−)-(2S, 3R, 4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane, the abbott pseudodipeptidyl insert (1990) (13)
- Replacement of Phe6, Phe7, and Phe11 of D-Trp8-somatostatin-14 with L-pyrazinylalanine. Predicted and observed effects on binding affinities at hSST2 and hSST4. An unexpected effect of the chirality of Trp8 on NMR spectra in methanol. (2005) (12)
- Nonpeptidal Peptidomimetics with a β‐D‐Glucose Scaffolding. A Partial Somatostatin Agonist Bearing a Close Structural Relationship to a Potent, Selective Substance P Antagonist. (1993) (12)
- Synthesis of polypyrrolinones on solid support. (2000) (12)
- Synthesis of 2'-(2,4-Difluorophenyl)-11β,17,21-trihydroxy-6,16α-dimethyl-20- oxopregna-4,6-dieno[3,2-c]pyrazole (1964) (11)
- Characterization of synthetic parathyroid hormone analogs and of synthetic by-products (1989) (11)
- Enantioretentive alkylation of oxazolidinone aluminum enolates with epoxides: Preparation of uncoded homoserine analogs (1994) (11)
- A deuterium isotope effect on the inhibition of gastric secretion by N,N-dimethyl-N'-[2-(diisopropylamino)ethyl]-N'-(4,6-dimethyl-2-pyridyl)urea. Synthesis of metabolites. (1983) (11)
- Synthesis of Cortisone-21 Phosphate (1958) (11)
- Synthesis and binding affinities of novel SRIF-mimicking beta-D-glucosides satisfying the requirement for a pi-cloud at C1. (2005) (9)
- Cyclic peptide formation catalyzed by an antibody ligase. (2000) (9)
- Design, synthesis, and evaluation of a pyrrolinone-based matrix metalloprotease inhibitor. (2000) (9)
- SYMBIOTIC APPROACH TO DRUG DESIGN: ANTIHYPERTENSIVE β-ADRENERGIC BLOCKING AGENTS (1980) (9)
- Design, synthesis, and structural analysis of D,L-mixed polypyrrolinones. 1. From nonpeptide peptidomimetics to nanotubes. (2010) (7)
- Synthesis of alpha-methyl-DLg-glutathione. (1967) (7)
- Approaches to vasodilating/beta-adrenergic blocking agents: examples of the dihydrolutidine type. (1981) (7)
- The Structure of the Enol Acetate Derivatives of Steroid 7- and 11-Ketones (1953) (6)
- Synthesis of novel, highly potent cyclic-hexapeptide analogs of somatostatin. Potential application of orthogonal protection for affinity chromatography (1991) (6)
- A New Route to Desoxycholic Acid (1951) (6)
- The first synthesis of a tricyclic homodetic peptide employing coordinated orthogonal protection (1996) (6)
- SYNTHESIS OF THE FIRST TRICYCLIC HOMODETIC PEPTIDE. USE OF COORDINATED ORTHOGONAL DEPROTECTION TO ACHIEVE DIRECTED RING CLOSURE (1998) (5)
- SYNTHESIS OF INDOMETHACIN METABOLITES. (1964) (5)
- Photochemical Redox Reaction of Aqueous Benzylpentacyanocobaltate(III) (1976) (5)
- Pyrrolinone‐Based HIV Protease Inhibitors. Design, Synthesis, and Antiviral Activity: Evidence for Improved Transport. (1996) (5)
- Development of an Efficient, Regio‐ and Stereoselective Route to Libraries Based on the β‐D‐Glucose Scaffold. (2001) (5)
- Design, synthesis, and structural analysis of D,L-mixed polypyrrolinones. 2. Macrocyclic hexapyrrolinones. (2010) (5)
- A practical synthesis of Nalpha-Fmoc-L-pyrazinylalanine via Schöllkopf's chiral auxiliary. (2008) (5)
- The β‐D‐Glucose Scaffold as a β‐Turn Mimetic (2010) (5)
- Beta 1-selective adrenoceptor antagonists: examples of the 2-[4-[3-(substituted-amino)-2-hydroxypropoxy]phenyl]imidazole class. (1983) (4)
- Phosphonate Diester and Phosphonamide Synthesis. Reaction Coordinate Analysis by 31P NMR Spectroscopy: Identification of Pyrophosphonate Anhydrides and Highly Reactive Phosphonylammonium Salts. (1998) (4)
- SYNTHESIS AND ANTIHYPERTENSIVE ACTIVITY OF SOME ESTER PROGENITORS OF METHYLDOPA (1978) (4)
- Synthesis of thyrotropin-releasing hormone analogs with selective central nervous system effects (1981) (4)
- Structure and Hydrogenation of Key Intermediates in the Equilenin Synthesis1,2 (1951) (4)
- INHIBITORS OF GASTRIC ACID SECRETION: 3,4-DIAMINO-1,2,5-THIADIAZOLE 1-OXIDES AND 1,1-DIOXIDES AS UREA EQUIVALENTS IN A SERIES OF HISTAMINE H2 RECEPTOR ANTAGONISTS (1982) (3)
- Phosphonyltriethylammonium Salts: Novel Reactive Species for the Synthesis of Phosphonate Esters and Phosphonamides. (1995) (3)
- Efficacy of water-soluble derivatives of vitamin K1 in counteracting drug-induced hypoprothrombinemia. (1959) (3)
- Tactics for Minimal Protection in Peptide Synthesis (1973) (3)
- APPROACHES TO VASODILATING/β-ADRENERGIC BLOCKING AGENTS: EXAMPLES OF THE DIHYDROLUTIDINE TYPE (1981) (3)
- Thyrocalcitonin. II. Enzymatic and chemical sequence studies. (1968) (2)
- The controlled synthesis of peptides in aqueous medium. 8. The preparation and use of novel alpha-amino acid N-carboxyanhydrides. (1971) (2)
- Chemoselective monoalkylation of 5-trifluoroacetamido- and 5-acetamido-1-pentanol derivatives via N,O-bisdeprotonation. Quantitation of evolved H2 as a probe of anion formation (1995) (2)
- A New Synthesis of the 6-Methoxy-17-equilenones and Some Stereochemical Considerations (1951) (2)
- Novel ligands lacking a positive charge for the delta- and mu-opioid receptors. (2000) (2)
- The First Design and Synthesis of a Steroidal Peptidomimetic. The Potential Value of Peptidomimetics in Elucidating the Bioactive Conformation of Peptide Ligands. (1993) (2)
- SOME RECENT DEVELOPMENTS IN THE SYNTHESIS OF BIOLOGICALLY ACTIVE PEPTIDES (1978) (2)
- CHARACTERIZATION OF SYNTHETIC PEPTIDE HORMONE ANALOGS AND OF BYPRODUCTS (1987) (2)
- A Second‐Generation Synthesis of Polypyrrolinone Nonpeptidomimetics: Prelude to the Synthesis of Polypyrrolinones on Solid Support. (2000) (2)
- [Effectiveness and tolerance of aerosol disodium cromoglycate in children with bronchial asthma]. (1991) (2)
- Some novel, acid-labile amine protecting groups 1. (1977) (1)
- Design and Synthesis of a Tetrahydropyran‐Based Inhibitor of Mammalian Ribonucleotide Reductase. (1999) (1)
- Investigation of an antibody-ligase. Evidence for strain-induced catalysis. (2003) (1)
- Synthesis of Pregn-4-eno[3,2-c]pyrazoles Related to 9α-Fluoro-16α-methylcortisol 1 (1964) (1)
- 1.01 – Reflections of a Medicinal Chemist: Formative Years through Thirty-Seven Years Service in the Pharmaceutical Industry (2007) (1)
- INHIBITORS OF GASTRIC ACID SECRETION: ANTISECRETORY 2-PYRIDYLUREA DERIVATIVES (1983) (0)
- PIPERAZINYLPYRAZINES WITH CENTRAL SEROTONINMIMETIC ACTIVITY (1978) (0)
- Synthesis of the First Tricyclic Homodetic Peptide. Use of Coordinated Orthogonal Deprotection to Achieve Directed Ring Closure. (1998) (0)
- Peptide Bond Formation via Catalytic Antibodies: Synthesis of a Novel Phosphonate Diester Hapten. (2010) (0)
- Photochemical Redox Reaction of Aqueous Benzylpentacyanocobaltate(III). (1976) (0)
- Conformationally restricted bicyclic analogs of somatostatin (peptide conformation/peptide synthesis/hydrophobic bonding/hormone receptors/macrocycles) (0)
- A Versatile, Efficient Synthesis of (-)-(2S,3R,4S)-2-Amino-1- cyclohexyl-3,4-dihydroxy-6-methylheptane (I), the Abbott Pseudodipeptidyl Insert. (1991) (0)
- crystal structure of HIV-1 protease-hup (2004) (0)
- [Idiopathic lung hemosiderosis in a 3-year-old child following ductus ligation in the neonatal period]. (1985) (0)
- Design and Synthesis of Potent Cystine‐Free Cyclic Hexapeptide Agonists at the Human Urotensin Receptor. (2006) (0)
- SYNTHESIS OF 2'-(2,4-DIFLUOROPHENYL )-11-BETA, 17,21-TRIHYDROXY-6,16-ALPHA-DIMETHYL-20-OXOPREGNA-4,6-DIENO(3,2-C) PYRAZOLE. (1964) (0)
- “The time has come,” the Walrus said, “to talk of many things...” -Lewis Carroll, Through the Looking Glass (2002) (0)
- ISONICOTINYLOXYCARBONYL A NOVEL AMINO PROTECTING GROUP FOR PEPTIDE SYNTHESIS (1978) (0)
- The synthesis of an enzyme (2004) (0)
- A Second-Generation Synthesis of Scalemic 3,5,5-Trisubstituted Pyrrolin-4-ones: Incorporation of Functionalized Amino Acid Side- Chains. (1997) (0)
- Review of the Fogarty International Center Conference, NIH: peptides in health and disease. (2009) (0)
- Studies on the total synthesis of an enzyme. 3. Synthesis of a protected hexacontapeptide corresponding to the 65-124 sequence of ribonuclease A. (1969) (0)
- SYNTHESIS AND STEREOSPECIFIC ANTIPSYCHOTIC ACTIVITY OF (-)-1-CYCLOPROPYLMETHYL-4-(3-TRIFLUOROMETHYLTHIO-5H-DIBENZO(A,D)CYCLOHEPTEN-5-YLIDENE)PIPERIDINE (1977) (0)
- β-ADRENERGIC BLOCKING AGENTS WITH ACUTE ANTIHYPERTENSIVE ACTIVITY (1979) (0)
- ACETAMIDOMETHYL, NEUE THIOL-SCHUTZGRUPPE FUER CYSTEIN (1972) (0)
- PEPTIDE RESEARCH IN AN INDUSTRIAL ENVIRONMENT (1984) (0)
- Enantioretentive Alkylation of Oxazolidinone Aluminum Enolates with Epoxides: Preparation of Uncoded Homoserine Analogues. (1995) (0)
- A method for the controlled stepwise synthesis of peptides and protected derivatives thereof. (1966) (0)
- Chemoselective Monoalkylation of 5-Trifluoroacetamido- and 5-Acetamido- 1-pentanol Derivatives via N,O-Bisdeprotonation. Quantitation of Evolved H2 as a Probe of Anion Formation. (2010) (0)
- Design, Synthesis, and Evaluation of a Pyrrolinone—Peptide Hybrid Ligand for the Class II MHC Protein HLA-DR1 (1999) (0)
- A DEUTERIUM ISOTOPE EFFECT ON THE INHIBITION OF GASTRIC SECRETION BY N,N-DIMETHYL-N′-(2-(DIISOPROPYLAMINO)ETHYL)-N′-(4,6-DIMETHYL-2-PYRIDYL)UREA. SYNTHESIS OF METABOLITES (1984) (0)
- A process for producing a cysteine-containing peptides (1968) (0)
- Oegonmedicinpreparat intended one Foer lokal Treatment of foerhoejt intraokulart-pressure Vilka innehaoller kolsyraanhydrasinhibitorer Science S - (-) - 1- (tert-butylamino) -3 - / (4-morpholino-1,2,5-tiadiazol-3-yl) oxy / - 2-propanol (1980) (0)
- Thiol Protection with the Acetamidomethyl Group: S‐Acetamidomethyl‐L‐Cysteine Hydrochloride (2003) (0)
- An Effective Synthesis of Scalemic 3,5,5-Trisubstituted Pyrrolin-4- ones. (1993) (0)
- An Approach to Peripheral Vasodilator-β-adrenergic Blocking Agents. (1977) (0)
- Recent developments in peptidomimetic research at the University of Pennsylvania (1993) (0)
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