Ralph Snyderman

Q: What Schools Are Affiliated With Ralph Snyderman

Ralph Snyderman is affiliated with the following schools: Washington College, Washington University in St. Louis, SUNY Downstate Medical Center, Johns Hopkins University, Duke University

Why Is Ralph Snyderman Influential?

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According to Wikipedia, Ralph Snyderman is a former member of the Purdue Pharma Board of Directors , Chancellor Emeritus at Duke University, James B. Duke Professor of Medicine, and Executive Director of the Duke Center for Personalized Health Care. He served as chancellor for health affairs and dean of the School of Medicine from 1989 to July 2004. Under his leadership, Duke University created the Duke University Health System to develop and operate a comprehensive health delivery system, and he was its founding President and Chief Executive Officer. DUHS, with its practice networks, ambulatory care centers, home health services, community hospitals, university hospital, and satellite collaborations demonstrated the power of academic medicine to deliver the best of care to broad communities. Snyderman helped lead the creation of the largest academic clinical research organization worldwide. During his tenure, Duke University Hospital was ranked 6th overall in the nation and its medical school ranked 4th. Snyderman is a leader in the conception and development of personalized health care, an evolving model of national health care delivery. He has articulated the need to move the current focus of health care from the treatment of disease-events to personalized, predictive, preventive, and participatory care that is focused on the patient. As Senior Vice-President at Genentech, he led the development of powerful new molecular biology therapeutics. Ralph Snyderman was the recipient of the 2012 David E. Rogers Award from the Association of American Medical Colleges which recognized him as "The Father of Personalized Medicine." He is a member of the Association of American Medical Colleges , Association of American Physicians , American Academy of Arts & Sciences, and the National Academy of Medicine.

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Ralph Snyderman's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Inflammation: Basic Principles and Clinical Correlates (1992) (1913)
A potential second messenger role for unsaturated fatty acids: activation of Ca2+-dependent protein kinase. (1984) (549)
rac, a novel ras-related family of proteins that are botulinum toxin substrates. (1989) (548)
Specific receptor sites for chemotactic peptides on human polymorphonuclear leukocytes. (1977) (508)
Inhibition of lymphocyte proliferation by a synthetic peptide homologous to retroviral envelope proteins. (1985) (412)
Molecular and cellular mechanisms of leukocyte chemotaxis. (1981) (398)
Identification of beta-adrenergic receptors in human lymphocytes by (-) (3H) alprenolol binding. (1976) (360)
The chemotactic attraction of human fibroblasts to a lymphocyte-derived factor (1976) (348)
Regulation of Human Chemokine Receptors CXCR4 (1997) (309)
An inherited abnormality of neutrophil adhesion. Its genetic transmission and its association with a missing protein. (1980) (290)
Chemoattractant Receptor Cross-desensitization* (1999) (289)
Chemotactic and Anaphylatoxic Fragment Cleaved from the Fifth Component of Guinea Pig Complement (1968) (280)
Activation of the respiratory burst enzyme from human neutrophils in a cell-free system. Evidence for a soluble cofactor. (1985) (274)
Receptor-coupled activation of phosphoinositide-specific phospholipase C by an N protein. (1986) (271)
Human mononuclear leukocyte chemotaxis: a quantitative assay for humoral and cellular chemotactic factors. (1972) (265)
Phorbol myristate acetate mediates redistribution of protein kinase C in human neutrophils: potential role in the activation of the respiratory burst enzyme. (1985) (260)
Chemoattractant receptor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate in human polymorphonuclear leukocyte membranes. Requirement for a guanine nucleotide regulatory protein. (1985) (248)
Stimulation of neutrophil oxidative metabolism by chemotactic peptides: influence of calcium ion concentration and cytochalasin B and comparison with stimulation by phorbol myristate acetate. (1979) (233)
Neisseria meningitidis and Neisseria gonorrhoeae bacteremia associated with C6, C7, or C8 deficiency. (1979) (230)
Chemoattractant receptors on phagocytic cells. (1984) (222)
Calcium influx requirement for human neutrophil chemotaxis: inhibition by lanthanum chloride. (1976) (216)
Opiates transdeactivate chemokine receptors: delta and mu opiate receptor-mediated heterologous desensitization. (1998) (216)
INTERACTIONS OF THE COMPLEMENT SYSTEM WITH ENDOTOXIC LIPOPOLYSACCHARIDE (1968) (214)
Activation of the respiratory burst enzyme in human polymorphonuclear leukocytes by chemoattractants and other soluble stimuli. Evidence that the same oxidase is activated by different transductional mechanisms. (1983) (212)
The NADPH oxidase of human polymorphonuclear leukocytes. Evidence for regulation by multiple signals. (1984) (209)
Targeted Disruption of the Leukotriene B4Receptor in Mice Reveals Its Role in Inflammation and Platelet-Activating Factor–Induced Anaphylaxis (2000) (186)
Human calcium‐calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine‐177 by calcium‐calmodulin dependent protein kinase I kinase. (1995) (180)
Potential role for a guanine nucleotide regulatory protein in chemoattractant receptor mediated polyphosphoinositide metabolism, Ca++ mobilization and cellular responses by leukocytes. (1985) (179)
Cross-desensitization of receptors for peptide chemoattractants. Characterization of a new form of leukocyte regulation. (1994) (177)
Differences in phosphorylation of formylpeptide and C5a chemoattractant receptors correlate with differences in desensitization. (1993) (174)
Guanine nucleotides modulate the binding affinity of the oligopeptide chemoattractant receptor on human polymorphonuclear leukocytes. (1983) (174)
An inhibitor of macrophage chemotaxis produced by neoplasms. (1976) (172)
A human mononuclear leukocyte chemotactic factor: characterization, specificity and kinetics of production by homologous leukocytes. (1973) (171)
Integrative medicine: bringing medicine back to its roots. (2002) (169)
A role for adenosine deaminase in human monocyte maturation. (1976) (167)
BIOLOGICAL ACTIVITY OF COMPLEMENT IN VIVO ROLE OF C5 IN THE ACCUMULATION OF POLYMORPHONUCLEAR LEUKOCYTES IN INFLAMMATORY EXUDATES (1971) (167)
Role of the Cytoplasmic Tails of CXCR1 and CXCR2 in Mediating Leukocyte Migration, Activation, and Regulation1 (2003) (163)
Differential Cross-regulation of the Human Chemokine Receptors CXCR1 and CXCR2 (1998) (163)
Depression of macrophage function by a factor produced by neoplasms: a merchanism for abrogation of immune surveillance. (1976) (162)
A neutrophil chemotatic factor derived from C'5 upon interaction of guinea pig serum with endotoxin. (1969) (160)
Model for Leukocyte Regulation by Chemoattractant Receptors: Roles of a Guanine Nucleotide Regulatory Protein and Polyphosphoinositide Metabolism (1986) (159)
Macrophage Activation (1984) (158)
Polymorphonuclear Leukocyte Chemotactic Activity in Rabbit Serum and Guinea Pig Serum Treated with Immune Complexes: Evidence for C5a as the Major Chemotactic Factor (1970) (149)
Receptor class desensitization of leukocyte chemoattractant receptors. (1991) (148)
Biologic and biochemical activities of continuous macrophage cell lines P388D1 and J774.1. (1977) (148)
Regulation of stably transfected platelet activating factor receptor in RBL-2H3 cells. Role of multiple G proteins and receptor phosphorylation. (1994) (143)
Patient engagement as a risk factor in personalized health care: a systematic review of the literature on chronic disease (2014) (141)
The oligopeptide chemotactic factor receptor on human polymorphonuclear leukocyte membranes exists in two affinity states. (1982) (140)
Nucleotide regulatory protein-mediated activation of phospholipase C in human polymorphonuclear leukocytes is disrupted by phorbol esters. (1987) (138)
Effects of neoplasms on inflammation: depression of macrophage accumulation after tumor implantation. (1976) (137)
Immunosuppressive activity of the retroviral envelope protein P 15E and its possible relationship to neoplasia. (1984) (137)
Requirement of S-adenosyl-L-methionine-mediated methylation for human monocyte chemotaxis. (1978) (137)
Factors from saliva and oral bacteria, chemotactic for polymorphonuclear leukocytes: their possible role in gingival inflammation. (1970) (134)
Pneumonitis complicating low-dose methotrexate therapy in rheumatoid arthritis. (1985) (132)
A conserved region at the COOH terminus of human immunodeficiency virus gp120 envelope protein contains an immunodominant epitope. (1987) (126)
Do macrophages destroy nascent tumors? (1979) (125)
Chemoattractant stimulus-response coupling (1992) (123)
Role of a guanine nucleotide regulatory protein in the activation of phospholipase C by different chemoattractants. (1987) (121)
Cross-desensitization of Chemoattractant Receptors Occurs at Multiple Levels (1995) (115)
Substance P primes human neutrophil activation: a mechanism for neurological regulation of inflammation. (1989) (113)
Chemoattractant Receptors Activate Distinct Pathways for Chemotaxis and Secretion (1999) (113)
Inhibitors of monocyte responses to chemotaxins are present in human cancerous effusions and react with monoclonal antibodies to the P15(E) structural protein of retroviruses. (1981) (112)
Mechanisms of inflammation and leukocyte activation. (1997) (112)
Neutralization of sensitized virus by purified components of complement. (1970) (111)
A Chemotactic Factor for Mononuclear Leukocytes 1 (1971) (109)
Personalized health care: From theory to practice (2012) (108)
Regulation of human interleukin-8 receptor A: identification of a phosphorylation site involved in modulating receptor functions. (1995) (106)
Chemoattractant-elicited alterations of cAMP levels in human polymorphonuclear leukocytes require a Ca2+-dependent mechanism which is independent of transmembrane activation of adenylate cyclase. (1985) (106)
Macrophage accumulation in mice is inhibited by low molecular weight products from murine leukemia viruses. (1980) (104)
Significance of complement to the mechanism of action of endotoxin. (1969) (104)
Monocyte responsiveness to chemotactic stimuli is a property of a subpopulation of cells that can respond to multiple chemoattractants. (1981) (102)
A synthetic peptide homologous to the envelope proteins of retroviruses inhibits monocyte-mediated killing by inactivating interleukin 1. (1987) (101)
Demonstration of a chemotactic factor receptor on macrophages. (1980) (98)
Inhibition of human natural killer cell activity by a synthetic peptide homologous to a conserved region in the retroviral protein, p15E. (1987) (98)
Prospective Medicine: The Next Health Care Transformation (2003) (94)
Redistribution of protein kinase C activity in human monocytes: correlation with activation of the respiratory burst. (1985) (93)
Similarity between p15E of murine and feline leukaemia viruses and p21 of HTLV (1984) (92)
DEPRESSED MONOCYTE CHEMOTAXIS DURING ACUTE INFLUENZA INFECTION (1975) (92)
Immunologic Reactions and Periodontal Inflammation (1970) (91)
Calcium influx stimulates a second pathway for sustained diacylglycerol production in leukocytes activated by chemoattractants. (1988) (91)
Abnormalities of Monocyte Chemotaxis in Patients With Melanoma: Effects of Immunotherapy and Tumor Removal (1977) (87)
Abnormalities of chemotactic lymphokine synthesis and mononuclear leukocyte chemotaxis in Wiskott-Aldrich syndrome. (1974) (87)
Role of Phospholipase Cβ3 Phosphorylation in the Desensitization of Cellular Responses to Platelet-activating Factor* (1997) (85)
Defective mononuclear leukocyte chemotaxis: a previously unrecognized immune dysfunction. Studies in a patient with chronic mucocutaneous candidiasis. (1973) (85)
Abnormal monocyte chemotaxis in patients with breast cancer: evidence for a tumor-mediated effect. (1978) (84)
Abortive and productive infections of human mononuclear phagocytes by type I herpes simplex virus. (1978) (83)
Development of specific receptors for N-formylated chemotactic peptides in a human monocyte cell line stimulated with lymphokines (1980) (82)
Defective monocyte function in patients with genitourinary carcinoma. (1975) (81)
Homologous and heterologous skin transplantation in patients with lymphomatous disease. (1961) (81)
Familial deficiency of the seventh component of complement associated with recurrent bacteremic infections due to Neisseria. (1978) (80)
Inhaled asbestos activates a complement-dependent chemoattractant for macrophages. (1985) (80)
Quantification of mouse macrophage chemotaxis in vitro: role of C5 for the production of chemotactic activity (1975) (80)
Identification of the ral and rac1 gene products, low molecular mass GTP-binding proteins from human platelets. (1989) (79)
Neutralization of Sensitized Virus by the Fourth Component of Complement (1969) (79)
Suppression of the respiratory burst of human monocytes by a synthetic peptide homologous to envelope proteins of human and animal retroviruses. (1986) (78)
Regulation of the Human Chemokine Receptor CCR1 (2000) (77)
Multiple Signaling Pathways of Human Interleukin-8 Receptor A (1998) (75)
Macrophage proteinase and inflammation: the production of chemotactic activity from the fifth complement by macrophage proteinase. (1972) (74)
Generation of a fibroblast chemotactic factor in serum by activation of complement. (1979) (71)
Depression of human monocyte chemotaxis by herpes simplex and influenza viruses. (1974) (68)
A chemoattractant receptor on macrophages exists in two affinity states regulated by guanine nucleotides (1984) (68)
Amphotericin B alters the affinity and functional activity of the oligopeptide chemotactic factor receptor on human polymorphonuclear leukocytes. (1982) (66)
Humoral mediators of chemotaxis of mononuclear leukocytes. (1972) (65)
N-Formylmethionyl peptide receptors on equine leukocytes initiate secretion but not chemotaxis. (1980) (65)
Differential stimulation of the respiratory burst and lysosomal enzyme secretion in human polymorphonuclear leukocytes by synthetic diacylglycerols. (1986) (63)
Mastoparan, a wasp venom peptide, identifies two discrete mechanisms for elevating cytosolic calcium and inositol trisphosphates in human polymorphonuclear leukocytes. (1989) (63)
Chemotaxis of Macrophages (1976) (62)
Interleukin-8-mediated Heterologous Receptor Internalization Provides Resistance to HIV-1 Infectivity (2003) (61)
Inflammation and Herpes Simplex Virus: Release of a Chemotaxis-Generating Factor from Infected Cells (1970) (61)
Signal transduction in cells following binding of chemoattractants to membrane receptors (1988) (61)
Rapid changes in light scattering from human polymorphonuclear leukocytes exposed to chemoattractants. Discrete responses correlated with chemotactic and secretory functions. (1984) (60)
Differential Regulation of Formyl Peptide and Platelet-activating Factor Receptors (1998) (60)
Chemoattractant Receptor-induced Phosphorylation of L-selectin* (1997) (59)
Meeting the Challenges Facing Clinical Research: Solutions Proposed by Leaders of Medical Specialty and Clinical Research Societies (2006) (59)
Phospholipid methylation in macrophages is inhibited by chemotactic factors. (1979) (58)
Transmethylation reactions regulate affinity and functional activity of chemotactic factor receptors on macrophages (1982) (57)
Human retrovirus-related synthetic peptides inhibit T lymphocyte proliferation. (1988) (56)
Human Gi protein α‐subunit: deduction of amino acid structure from a cloned cDNA (1987) (56)
Suppressive effect on polyclonal B-cell activation of a synthetic peptide homologous to a transmembrane component of oncogenic retroviruses. (1987) (56)
Prospective health care: the second transformation of medicine (2006) (55)
Murine malignant cells synthesize a 19,000-dalton protein that is physicochemically and antigenically related to the immunosuppressive retroviral protein, P15E (1983) (55)
A pertussis/choleratoxin-sensitive N protein may mediate chemoattractant receptor signal transduction. (1986) (55)
Effect of virus infection on the inflammatory response. Depression of macrophage accumulation in influenza-infected mice. (1976) (55)
Cultural and organizational implications of academic managed-care networks. (1994) (54)
Role for Endotoxin and Complement in Periodontal Tissue Destruction (1972) (54)
Function and regulation of chemoattractant receptors (2000) (53)
The formylpeptide chemoattractant receptor copurifies with a GTP-binding protein containing a distinct 40-kDa pertussis toxin substrate. (1988) (52)
Deficiency of the fifth component of complement in human subjects. Clinical, genetic and immunologic studies in a large kindred. (1979) (52)
Chronic mucocutaneous candidiasis. Immunologic studies of three generations of a single family. (1979) (52)
Molecular cloning of a new human G protein Evidence for two Giα‐like protein families (1987) (51)
Identification of additional members of human G-protein-coupled receptor kinase multigene family. (1993) (50)
Isolation of GTP-binding proteins from myeloid HL-60 cells. Identification of two pertussis toxin substrates. (1987) (50)
Reaction of a Cobra Venom Factor with Guinea Pig Complement and Generation of an Activity Chemotactic for Polymorphonuclear Leukocytes∗ (1969) (50)
Augmentation of human monocyte chemotactic response by levamisole (1976) (50)
Characterization of chemotactic activity produced in vivo by a cell-mediated immune reaction in the guinea pig. (1975) (49)
Cyclic nucleotides regulate the morphologic alterations required for chemotaxis in monocytes. (1982) (49)
Chemoattractant-mediated stimulation of the respiratory burst in human polymorphonuclear leukocytes may require appearance of protein kinase activity in the cells' particulate fraction. (1986) (49)
Human malignant and mitogen-transformed cells contain retroviral P15E- related antigen (1984) (48)
Abnormalities of leukotaxis in atopic dermatitis. (1977) (48)
Cross-desensitization Among Receptors for Platelet Activating Factor and Peptide Chemoattractants (1996) (48)
Mechanisms of regulating the respiratory burst in leukocytes. (1984) (48)
Macrophage migratory dysfunction in cancer. A mechanism for subversion of surveillance. (1977) (46)
Decreased properdin activity in acute glomerulonephritis. (1969) (46)
Activation of complement by endotoxin. (1973) (46)
Personalized medicine is more than genomic medicine: confusion over terminology impedes progress towards personalized healthcare. (2012) (45)
Isoprenylation of the low molecular mass GTP-binding proteins rac 1 and rac 2: possible role in membrane localization. (1990) (45)
Rac1, a low-molecular-mass GTP-binding-protein with high intrinsic GTPase activity and distinct biochemical properties. (1992) (45)
Chemotactically responsive and nonresposive forms of a continuous human monocyte cell line. (1980) (45)
Hormonal activation of adenylate cyclase in macrophage membranes is regulated by guanine nucleotides. (1983) (45)
Transmethylation reactions are required for initial morphologic and biochemical responses of human monocytes to chemoattractants. (1981) (45)
ABNORMALITIES OF LEUKOCYTE CHEMOTAXIS IN HUMAN DISEASE * (1975) (44)
Prospective care: a personalized, preventative approach to medicine. (2006) (44)
Interaction of complex polysaccharides with the complement system: effect of calcium depletion on terminal component consumption (1975) (44)
Personalized Health Planning (2003) (44)
Production of Chemotactic Factor and Lymphotoxin by Human Leukocytes Stimulated with Herpes Simplex Virus (1974) (44)
Role of transmethylation reactions in cellular motility and phagocytosis. (1980) (44)
Human IFN-gamma production is inhibited by a synthetic peptide homologous to retroviral envelope protein. (1988) (44)
Decreased C'-1q protein concentration and agglutinating activity in agammaglobulinaemia syndromes: an inborn error reflected in the complement system. (1968) (44)
Identification of a region at the N-terminus of phospholipase C-beta 3 that interacts with G protein beta gamma subunits. (2000) (43)
Opiates Transdeactivate Chemokine Receptors: δ and μ Opiate Receptor–mediated Heterologous Desensitization (1998) (42)
Characterization of G25K, a GTP-binding protein containing a novel putative nucleotide binding domain. (1989) (42)
Induction of selective biological responses to chemoattractants in a human monocyte-like cell line (1983) (41)
Regulation of inositol phosphate metabolism in chemoattractant-stimulated human polymorphonuclear leukocytes. Definition of distinct dephosphorylation pathways for IP3 isomers. (1987) (41)
Generalized microsporum audoninii infection and depressed cellular immunity associated with a missing plasma factor required for lymphocyte blastogenesis. (1977) (41)
Cellular serine proteinase induces chemotaxis by complement activation (1977) (41)
The inflammatory response and resistance to endotoxin in mice. (1978) (40)
Polymorphonuclear leukocyte function in psoriasis: chemotaxis, chemokinesis, beta-adrenergic receptors, and proteolytic enzymes of polymorphonuclear leukocytes in the peripheral blood from psoriatic patients. (1983) (40)
Depression of Murine Macrophage Accumulation by Low-Molecular-Weight Factors Derived From Spontaneous Mammary Carcinomas (1980) (40)
Perspective: Prospective health care and the role of academic medicine: lead, follow, or get out of the way. (2008) (39)
Transductional mechanisms of chemoattractant receptors on leukocytes. (1984) (38)
Inherited human complement C5 deficiency. Nonsense mutations in exons 1 (Gln1 to Stop) and 36 (Arg1458 to Stop) and compound heterozygosity in three African-American families. (1995) (36)
Resistance of neoplasms to immunological destruction: role of a macrophage chemotaxis inhibitor (1978) (36)
Improving health by taking it personally. (2010) (36)
Identification of O-Adrenergic Receptors in Human Lymphocytes by ( ) [ 3 H ] Alprenolol Binding (36)
Intrinsic defect of the polymorphonuclear leukocyte resulting in impaired chemotaxis and phagocytosis (1971) (36)
The clinical researcher--an "emerging" species. (2004) (36)
Chemotactic factor and P15E-related chemotaxis inhibitor in human melanoma cell lines with different macrophage content and tumorigenicity in nude mice. (1987) (36)
Thrombin Primes Responsiveness of Selective Chemoattractant Receptors at a Site Distal to G Protein Activation (*) (1996) (35)
Depression of lymphocyte transformation and exacerbation of Behcet's syndrome by ingestion of english walnuts. (1973) (35)
INTERACTIONS OF THE COMPLEMENT SYSTEM WITH ENDOTOXIC LIPOPOLYSACCHARIDES IN IMMUNOGLOBULIN-DEFICIENT SERA (1970) (35)
Modulation of inositol phospholipid metabolism by polyamines. (1988) (35)
Hereditary C2 deficiency associated with cutaneous lupus erythematosus: clinical, laboratory, and genetic studies. (1979) (34)
Activation of complement by endotoxin: a role for 2 globulin, C1, C4 and C2 in the consumption of terminal complement components by endotoxin-coated erythrocytes. (1972) (33)
Prostaglandins and inflammation: enhancement of monocyte chemotactic responsiveness by prostaglandin E2. (1976) (32)
Coexistence of a chemotactic factor and a retroviral P15E-related chemotaxis inhibitor in human tumor cell culture supernatants. (1986) (31)
Characterization of human chemotactic lymphokine production induced by mitogens and mixed leukocyte reactions using a new microassay. (1977) (31)
Leukocyte activation by chemoattractant receptors: roles of a guanine nucleotide regulatory protein and polyphosphoinositide metabolism. (1987) (30)
Successful tumour immunotherapy: possible role of antibodies to anti-inflammatory factors produced by neoplasms. (1985) (30)
A Synthetic Peptide Homologous to Retroviral Transmembrane Envelope Proteins Depresses Protein Kinase C Mediated Lymphocyte Proliferation and Directly Inactivated Protein Kinase C: A Potential Mechanism for Immunosuppression (1991) (30)
Leukocyte chemoattraction by 1,2-diacylglycerol. (1988) (30)
Gauging supply and demand: the challenging quest to predict the future physician workforce. (2002) (29)
Influenza-induced depression of monocyte chemotaxis: Reversal by levamisole☆ (1977) (29)
Inflammation and viral infection: chemotactic activity resulting from the interaction of antiviral antibody and complement with cells infected with herpes simplex virus. (1972) (29)
Role of guanine nucleotide regulatory protein in polyphosphoinositide degradation and activation of phagocytic leukocytes by chemoattractants (1986) (28)
Chemoattractant-induced activation of c-fos gene expression in human monocytes (1987) (28)
Prospective medicine: the role for genomics in personalized health planning. (2004) (28)
Histamine-Releasing Factor Generated by the Interaction of Endotoxin with Hamster Serum (1970) (28)
Regulatory mechanisms of a chemoattractant receptor on leukocytes. (1984) (26)
Regulation of Leukocyte Function (1984) (26)
Integrative medicine and the search for the best practice of medicine. (2002) (25)
Stimulation of phosphorylcholine turnover and diacylglycerol production in human polymorphonuclear leukocytes. Novel assay for phosphorylcholine. (1989) (25)
Macrophage Proteinase and Inflammation: The Production of Chemotactic Activity from the Fifth Component of Complement by Macrophage Proteinase (1972) (25)
Lymphoma models for B cell activation and tolerance. V. Anti-Ig mediated growth inhibition is reversed by phorbol myristate acetate but does not involve changes in cytosolic free calcium. (1987) (25)
Human lymphocyte motility: normal characteristics and anomalous behavior of chronic lymphocytic leukemia cells (1976) (25)
Recombinant hydrophilic region of murine retroviral protein p15E inhibits stimulated T-lymphocyte proliferation. (1987) (24)
DEFECTIVE MACROPHAGE MIGRATION PRODUCED BY NEOPLASMS: IDENTIFICATION OF AN INHIBITOR OF MACROPHAGE CHEMOTAXIS1 (1976) (24)
Differential anti-inflammatory effects of LPS in susceptible and resistant mouse strains. (1981) (23)
Neisseria meningitidis bacteremia in association with deficiency of the sixth component of complement (1979) (23)
Role of phospholipase Cbeta3 phosphorylation in the desensitization of cellular responses to platelet-activating factor. (1997) (22)
Lipid requirements for leukocyte chemotaxis and phagocytosis: effects of inhibitors of phospholipid and cholesterol synthesis. (1980) (22)
Proposal for a new health record to support personalized, predictive, preventative and participatory medicine. (2008) (22)
Commentary: Personalized Health Planning and the Patient Protection and Affordable Care Act: An Opportunity for Academic Medicine to Lead Health Care Reform (2010) (21)
Personalized Health Planning in Primary Care Settings. (2016) (21)
Production of chemotactic activity by guinea pig immunoglobulins following activation of the C3 complement shunt pathway. (1972) (21)
The relationship of complement consumption to immune fever. (1971) (20)
Multiple chromatographic forms of the formylpeptide chemoattractant receptor and their relationship to GTP-binding proteins. (1989) (20)
Periodontal disease: a model for the study of inflammation. (1971) (20)
Personalized Health Care as a Pathway for the Adoption of Genomic Medicine (2012) (20)
Alterations of new methylated phospholipid synthesis in the plasma membranes of macrophages exposed to chemoattractants (1981) (20)
Influence of cytoskeletal assembly on phosphatidylcholine synthesis in intact phagocytic cells (1980) (19)
Immunological mechanisms of periodontal tissue destruction. (1973) (19)
Light scattering by polymorphonuclear leukocytes stimulated to aggregate under various pharmacologic conditions (1984) (19)
Mechanisms of inflammation and leukocyte chemotaxis in the rheumatic diseases. (1986) (18)
Extensive hydrolysis of N-formyl-L-methionyl-L-leucyl-L-[3H] phenylalanine by human polymorphonuclear leukocytes. A potential mechanism for modulation of the chemoattractant signal. (1986) (18)
Leukocyte chemoattractant receptors. (1988) (18)
Functional high efficiency expression of cloned leucocyte chemoattractant receptor cDNAs (1992) (17)
Effect of Membrane Fluidizers on the Number and Affinity of Chemotactic Factor Receptors on Human Polymorphonuclear Leukocytes (1983) (17)
Disorders of leukocyte chemotaxis. (1977) (17)
Binding of alpha 2-macroglobulin-thrombin complexes and methylamine-treated alpha 2-macroglobulin to human blood monocytes. (1988) (16)
Differential regulation of cAMP by endogenous versus transfected formylpeptide chemoattractant receptors: implications for Gi-coupled receptor signaling. (1992) (16)
Regulation of inositol phospholipid and inositol phosphate metabolism in chemoattractant‐activated human polymorphonuclear leukocytes (1987) (16)
Pharmacologic manipulation of leukocyte chemotaxis. Present knowledge and future trends. (1983) (16)
The role of transmethylation reactions in regulating the binding of BCG-activated murine macrophages to neoplastic target cells. (1981) (15)
Consumption of hamster complement by bacterial endotoxin. (1970) (15)
Value of Personalized Medicine. (2016) (15)
Oversight Mechanisms for Clinical Research (2000) (15)
Effects of CKS-17, a synthetic retroviral envelope peptide, on cell-mediated immunity in vivo: Immunosuppression, immunogenicity, and relation to immunosuppressive tumor products (2005) (15)
Human lymphocyte motility: normal characteristics and anomalous behavior of chronic lymphocytic leukemia cells. (1976) (14)
Regulatory mechanisms of a chemoattractant receptor on human polymorphonuclear leukocytes. (1985) (14)
Further Characterization of a Factor From Endotoxin-Treated Serum which Releases Histamine and Heparin from Mast Cells (1972) (14)
Further studies of a macrophage chemotaxis inhibitor (MCI) produced by neoplasms: murine tumors free of lactic dehydrogenase virus produce MCI. (1979) (14)
Molecular cloning of the cDNA for ligatin. (1989) (14)
Effect of C4 depletion on the utilization of the terminal components of guinea-pig complement by endotoxin. (1971) (14)
Characterization of an oligopeptide chemoattractant receptor on human blood monocytes using a new radioligand. (1984) (14)
Light scattering by polymorphonuclear leukocytes stimulated to aggregate under various pharmacologic conditions. (1984) (13)
Immune fever in the rabbit: responses of the hematologic and complement systems. (1971) (13)
RGS4 inhibits platelet-activating factor receptor phosphorylation and cellular responses. (2001) (13)
Endotoxin (LPS) stimulates in vitro migration of macrophages from LPS-resistant mice but not from LPS-sensitive mice. (1982) (12)
Identification of a novel inositol bisphosphate isomer formed in chemoattractant stimulated human polymorphonuclear leukocytes. (1987) (12)
A potential second messenger role for arachidonic acid: activation of Ca2+-dependent protein kinase. (1984) (12)
AAP Presidential Address: The AAP and the transformation of medicine. (2004) (12)
CHEMOTAXIS OF HUMAN AND MURINE MONONUCLEAR PHAGOCYTES (1981) (12)
Complement‐Mediated Vasoconstriction and Graft Rejection (1972) (12)
Personalized medicine 2014: has healthcare been transformed? (2014) (11)
Advancing human health in the decade ahead: pregnancy as a key window for discovery (2020) (11)
The role of the immune response in the development of periodontal disease. (1973) (11)
Isolated Deficiencies of the Fifth and Eighth Components of Complement (C) in two Families: Clinical, Genetic and Biological Correlations (1978) (10)
An Inhibitor of Macrophage Accumulation Produced by Neoplasms: Its Role in Abrogating Host Resistance to Cancer (1980) (10)
Component deficiencies. 5. The fifth component. (1986) (10)
Inhibition of lymphocyte proliferation by a synthetic peptide homologous to envelope proteins of human and animal retroviruses. (1985) (10)
Compassion and Health Care: A Discussion With the Dalai Lama. (2019) (10)
As it was. (1992) (10)
Bone Marrow-Derived Lymphoid Cells (B Cells): Functional Depletion with Cobra Factor and Fresh Serum (1972) (10)
Human Gi protein alpha-subunit: deduction of amino acid structure from a cloned cDNA. (1987) (9)
Guanine nucleotide regulatory proteins in receptor-mediated polyphosphoinositide hydrolysis in human leukocytes. (1987) (9)
BIOLOGICAL ACTIVITY OF COMPLEMENT IN VIVO (1971) (9)
Integration of Personalized Health Planning and Shared Medical Appointments for Patients with Type 2 Diabetes Mellitus (2018) (9)
Chemotaxis of mononuclear leukocytes. (1974) (9)
Role of phosphate-magnesium-binding regions in the high GTPase activity of rac1 protein. (1993) (8)
Effect of vuris infection on the inflammatory response. (1976) (8)
Induction of cellular immunity to Coccidioides immitis after sensitization with dinitrochlorobenzene. (1982) (8)
Disorders of human leukocyte chemotaxis. (1981) (8)
Phospholipase C-β2 interacts with mitogen-activated protein kinase kinase 3 (2002) (8)
Rapid Changes in Light Scattering from Human (1984) (8)
Duke Clinical Research Institute (2016) (8)
Absence of macrophage involvement in the passive serum therapy of Friend leukemia virus-induced disease. (1980) (8)
Retroviral protein P15E and tumorigenesis. Expression is neither required nor sufficient for tumor development. (1988) (7)
Production of a retroviral P15E-related chemotaxis inhibitor by IL-1-treated endothelial cells. A possible negative feedback in the regulation of the vascular response to monokines. (1989) (7)
Chemoattractant receptor affinity reflects its ability to transduce different biological responses. (1983) (7)
A soluble inhibitor of T lymphocyte function induced by HIV-1 infection of CD4+ T cells: characterization of a cellular protein and its relationship to p15E. (1990) (7)
Chemotaxis of Inflammatory Cells (1971) (7)
The phagocytic cell: summary. (1985) (6)
Molecular cloning of a novel human GTP-binding protein and its potential role in chemoattractant stimulus-response coupling. (1987) (6)
Neoplasia and Mononuclear Phagocyte Function (1983) (6)
To Adopt Precision Medicine, Redesign Clinical Care (2017) (6)
Subacute bacterial endocarditis. (1949) (6)
Antibodies raised against purified β-adrenergic receptors specifically bind β-adrenergic ligands (1979) (6)
C5a: A Chemotactic Factor for Mononuclear Leukocytes (1971) (6)
BIOLOGICAL ACTIVITIES OF A MACROPHAGE CHEMOTAXIS INHIBITOR (MCI) PRODUCED BY NEOPLASMS (1979) (6)
An evaluation of mHealth adoption and health self-management in emerging adulthood (2019) (6)
Effects of tumor growth on host defenses (2004) (6)
Genetic control of peripheral leukocyte response to endotoxin in mice. (1980) (6)
Far beyond informed consent. US research institutions keep close watch on OPRR's suspensions. (1999) (6)
Altered cell-averaged microviscosity of murine peritoneal macrophages undergoing activation in vivo or in vitro. (1987) (5)
An inhibitor of macrophage function produced by neoplasms (1976) (4)
The new prevention. Research on causes of disease must be applied to remaking our care system. (2003) (4)
Personalized health care in 2013: a status report on the impact of genomics. (2013) (4)
CHAPTER 32 – The Role of Genomics in Enabling Prospective Health Care (2009) (4)
REQUIREMENT OF TRANSMETHYLATION REACTIONS FOR EUKARYOTIC CELL CHEMOTAXIS (1979) (4)
Abnormalitieis of monocyte chemotaxis in patients with melanoma: effects of immunotherapy and tumor removal. (1977) (4)
The Role of Genomics in Enabling Prospective Health Care (2010) (4)
Inhibitors of monocyte responses to chemotaxins are associated with human neoplasms. (1982) (4)
Biologic Aspects of Leukocyte Chemotaxis (1977) (4)
Creating meaningful health care reform. (2009) (3)
Monocyte chemotactic mechanisms in patients with hypernephroma. (1978) (3)
Depression of macrophage chemotaxis in vivo in tumor bearing mice. (1975) (3)
Health Care Reform in the United States. (2016) (3)
Chemoattractant Receptors and Signal Transduction Processes (1988) (3)
Macrophage accumulation inhibited by extracts of murine leukemia viruses (mlv). Abstr. (1979) (2)
Academic medicine can transform health care through clinical research. (1999) (2)
Tubular arrays on electron microscopy not specific. (1978) (2)
The Role of the Neutrophil in the Inflammatory Response (1985) (2)
Molecular mechanisms of leukocyte activation by chemoattractants. (1991) (2)
Biochemical and Biological Aspects of Leukocyte Chemotactic Factors (1980) (2)
Regulation of Mononuclear Leukocyte Function by Transmethylation Reactions a (1985) (2)
PHARMACOLOGICAL MANIPULATION OF THE CHEMOTACTIC FACTOR RECEPTOR ON LEUKOCYTES (1983) (2)
Behçet's disease--provocative clues. (1988) (2)
Mechanisms of Nonspecific Host Resistance (1981) (2)
Role of female genital function in creatine metabolism as revealed by the serum creatine tolerance test (1955) (2)
Phospholipase C-beta 2 interacts with mitogen-activated protein kinase kinase 3. (2002) (2)
SPECIFIC RECEPTORS AND TRANSMETHYLATION REACTIONS ARE REQUIRED FOR LEUKOCYTE CHEMOTAXIS (1982) (2)
QUANTITATION OF THE INFLAMMATORY ACCUMULATION OF MONONUCLEAR PHAGOCYTES IN VIVO (1981) (2)
Role of c5 in the accumulation of polymorphonuclear leukocytes (pmns) in mice treated with endotoxin. Abstr. (1971) (2)
Inhaled Asbestos Fibers Produce Complement-Derived Chemotactic Factor(s) on Alveolar Surfaces (1985) (2)
Does economic theory justify changing policy that works? (2001) (1)
RECEPTORS ON PHAGOCYTIC CELLS (1984) (1)
Molecular cloning of a new human G protein. Evidence for two Gi alpha-like protein families. (1987) (1)
Editorial: CD8 T cells cut back on calcium intake in the lungs (2010) (1)
A Chancellor's Tale: Transforming Academic Medicine (2016) (1)
Human Mononuclear Leukocyte Chemotaxis: Definition of Two Chemotactic Factors and a Previously Unrecognized Immune Dysfunction (1973) (1)
Updated Conflict of Interest Disclosures. (2023) (1)
Contemporary Topics in Immunobiology (1980) (1)
Quantification of Lymphokine Production in Human Disease (1979) (1)
Stimulus-response coupling of a chemoattractant receptor on mononuclear phagocytes (1985) (1)
BINDING OF SYNTHETIC CHEMOTACTIC PEPTIDES AS A MODEL OF LIGAND-RECEPTOR INTERACTION (1981) (1)
Patients, physicians, and clinical trials: the other side of the coins. (1999) (1)
Leukocyte chemotactic activity from oral bacteria. (1969) (1)
Antibodies raised against purified beta-adrenergic receptors specifically bind beta-adrenergic ligands. (1979) (1)
Similarity p15E of murine and feline leukaemia viruses and p21 of HTLV (1984) (1)
Ralph Snyderman, MD. CAM and the role of the academic health center. Interview by Bonnie Horrigan. (2000) (1)
Absenceof MacrophageInvolvement in the PassiveSerumTherapy of Friend LeukemiaVirus-induced Disease1 (1980) (1)
Regulation of Leukocyte Responses to Chemoattractants: Role of Receptors, Guanine Nucleotide Regulatory (N) Proteins and Phospholipase C (1987) (1)
Patient engagement as a risk factor in personalized health care: a systematic review of the literature on chronic disease (2014) (1)
History of the Academic Medical Center (2016) (1)
Personalized Medical Group Visits: A Novel Approach for the Care of Prediabetes (2022) (1)
Introduction of Robert J. Lefkowitz. (2011) (1)
Taking aim at Pharma (2004) (1)
Binding of. cap alpha. /sub 2/-macroglobulin-thrombin complexes and methylamine-treated. cap alpha. /sub 2/-macroglobulin to human blood monocytes (1988) (1)
Depression of murine macrophage accumulation by factors derived from spontaneous mammary carcinomas. Abstr. (1980) (1)
The academic health center and health care reform : proceedings of the Duke Private Sector Conference, 1994 (1995) (1)
Announcements (1984) (0)
Generation of chemotactic activity by immune complexes carrying clustered or nonclustered C42 sites. (1973) (0)
Role of a Guanine Nucleotide Regulatory Protein in the Polyphosphoinositide Pathway of Leukocyte Activation by Chemoattractant Receptors1 (1987) (0)
Getting Down to Business (2016) (0)
Clinical Research (2000) (0)
Abortive and Prpductive Infections of Human Mononuclear P,agocytes by Type I Herpes Simplex Virus (2007) (0)
Integrative Medicine Is a Trojan Horse—Reply (2002) (0)
Depression of murine macrophage accumulation by low-molecular-weight derived from spontaneous mammary carcinomas. (1980) (0)
Chemokine Receptor Expression and Regulatory Mechanisms (2019) (0)
In Reply to Goetz. (2020) (0)
Receptors and Transductional Events in Leukocyte Chemotaxis (1981) (0)
Misidentification of Patients in the Abstract and Author Affiliations. (2016) (0)
Mediators Of The Allergic State Recent Investigations Discover the best Kindle eBooks in Best Sellers Ralph Snyderman (2020) (0)
WELCOME AND ANNOUNCEMENTS (2004) (0)
A New Model of Care (2009) (0)
Stepping Down and Lessons Learned (2016) (0)
Personalizing Health Care (2016) (0)
Error in Title. (2016) (0)
Medicine and charity, then and now. (1989) (0)
Mediators of the allergic state: recent investigations (1972) (0)
Review of the national arthritis advisory board symposium, “molecular biology: its potential for advancing rheumatology research” (1987) (0)
Preventive surgery in the female breast. (1983) (0)
Learning the Business (2016) (0)
BIOLOGICAL A C T I V I T Y OF C O M P L E M E N T IN VIVO ROLE OF C5 IN THE ACCUMULATION OF POLYMORPHONUCLEAR LEUKOCYTES IN INFLAMMATORY EXUDATES (2003) (0)
The Truth About the Drug Companies: How They Deceive Us and What to Do About It By Marcia Angell (2004) (0)
Evolution of the Duke University Medical Center (2016) (0)
From Brooklyn to Duke (2016) (0)
Generation of chemotactic activity by immune complexes carrying clustered or nonclustered C&42horbar; sites (1973) (0)
Chemoattractant-induced membrane phenomena of phagocytes. (1988) (0)
Cytogenetic Engineering In Vivo : Restoration of Biologic Complement Activity to C 5-Deficient Mice by Intravenous Inoculation of Hybrid Cells ( mouse splenic macrophages / chicken erythrocytes / mouse kidney cells / genetic repair / MuBI protein ) (0)
The Debt Repayment Paradox for VA Clinical Investigators—Reply (2004) (0)
MISCELLANEOUS: Do macrophages destroy nascent tumors? (1980) (0)
PRESENTATION OF CANDIDATES FOR DEGREES (2003) (0)
Membrane fluidizers alter the affinity and transductional activity of a chemo tactic factor receptor on human neutrophils (1982) (0)
Philanthropy and Relationships (2016) (0)
Addendum to Chapter 2 (1984) (0)
Division of Physician-Provider Time Between Ambulatory and In-Bed Patients in the Various Medical Specialties-Reply (1986) (0)
THE CHEMOTACTIC ATTRACTION OF H U M A N FIBROBLASTS (2003) (0)
Integrative medicine is a trojan horse. Authors' reply (2002) (0)
[24] Chemoattractant-induced membrane phenomena of phagocytes (1988) (0)
Polymorphonuclear Leukocyte Chemotactic Activity (2003) (0)
Two Names Added to Additional Contributions Section. (2016) (0)
Mouse macrophage chemotaxis in vitro. Role for c5 as a source of chemotactic activity. Abstr. (1974) (0)
Mechanism of chemoattraction by mouse skin neutral proteinase (1979) (0)
Enhancing Diversity, Inclusion, and Community Relations (2016) (0)
From the Laboratory of Immune Effector Function (2003) (0)
Contents, Vol. 36, 1969 (1969) (0)
Reputation and Crisis (2016) (0)
INTEGRATIVE MEDICINE (2002) (0)
Methylation Reactions in the Regulation of Mononuclear Phagocyte Function (1983) (0)
A conserved region at the COOH terminus of human immunodeficiency virus gpl20 envelope protein contains an immunodominant epitope (acquired immunodeficiency syndrome/synthetic peptides/retrovirus/anti-viral antibodies) (2016) (0)
Further Characterization ofaFactor from Endotoxin-Treated SerumwhichReleases Histamine andHeparin fromMastCells (1972) (0)
Mediators of the chemotaxis of mononuclear leucocytes. (1973) (0)
Biochemical changes in leukocytes in response to chemoattractants. (1988) (0)
Fighting for Renewal (2016) (0)
Precision medicine: beyond genomics to targeted therapies. (2016) (0)
Internationales Komplement Symposion 14. und 15. Juli 1969 in Mainz (1969) (0)
RESULTS Generation of Chemotactic Activity for Rabbit PMN in Guinea Pig Peritoneal Exudates (2003) (0)
Production ofChemotactic Factor andLymphotoxin byHuman Leukocytes Stimulated withHerpes Simplex Virus (1974) (0)
Characterization of a tumor derived macrophage chemotaxis inhibitor (mci). Abstr. (1978) (0)
Internationales Komplement Symposion 14. und 15. Juli 1969 in Mainz (1969) (0)
More about prospective health care. (2009) (0)
Addition of an Omitted Word. (2016) (0)

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