Rama Ranganathan
American bioengineer
Rama Ranganathan's AcademicInfluence.com Rankings

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Engineering
Rama Ranganathan's Degrees
- PhD Bioengineering University of California, Berkeley
- Masters Bioengineering University of California, Berkeley
Why Is Rama Ranganathan Influential?
(Suggest an Edit or Addition)According to Wikipedia, Rama Ranganathan is an American bioengineer. Ranganathan studied bioengineering at the University of California, Berkeley, and earned a master's degree and doctorate at the University of California, San Diego. During his tenure at the University of Texas Southwestern Medical Center, he headed the Cecil H. and Ida Green Center for Systems Biology, and was a Howard Hughes Medical Investigator from 1997 to 2007. Ranganathan joined the University of Chicago faculty in 2017, as founding leader of the Center for Physics of Evolving Systems, a joint project of UChicago's Division of the Biological Sciences and the Institute for Molecular Engineering. In 2018, Ranganathan was appointed the Joseph Regenstein Professor in the Department of Biochemistry and Molecular Biology, as well as the Institute for Molecular Engineering.
Rama Ranganathan's Published Works
Published Works
- Evolutionarily conserved pathways of energetic connectivity in protein families. (1999) (1278)
- Structural and Functional Analysis of the Mitotic Rotamase Pin1 Suggests Substrate Recognition Is Phosphorylation Dependent (1997) (657)
- Protein Sectors: Evolutionary Units of Three-Dimensional Structure (2009) (643)
- Evolutionarily conserved networks of residues mediate allosteric communication in proteins (2003) (523)
- The spatial architecture of protein function and adaptation (2012) (414)
- Evolutionary information for specifying a protein fold (2005) (403)
- Evolutionarily conserved networks of residues mediate allosteric communication in proteins (2003) (349)
- Surface Sites for Engineering Allosteric Control in Proteins (2008) (325)
- Structural Determinants of Allosteric Ligand Activation in RXR Heterodimers (2004) (312)
- The structural basis for red fluorescence in the tetrameric GFP homolog DsRed (2000) (308)
- Arrestin function in inactivation of G protein-coupled receptor rhodopsin in vivo. (1993) (305)
- Hot Spots for Allosteric Regulation on Protein Surfaces (2011) (300)
- Spatial Localization of the K+ Channel Selectivity Filter by Mutant Cycle–Based Structure Analysis (1996) (279)
- A global analysis of cross-talk in a mammalian cellular signalling network (2006) (257)
- Natural-like function in artificial WW domains (2005) (248)
- Photoreceptor deactivation and retinal degeneration mediated by a photoreceptor-specific protein kinase C. (1991) (239)
- A Molecular Pathway for Light-Dependent Photoreceptor Apoptosis in Drosophila (2000) (233)
- Evolvability as a Function of Purifying Selection in TEM-1 β-Lactamase (2015) (218)
- PDZ domain proteins: Scaffolds for signaling complexes (1997) (187)
- A Drosophila mutant defective in extracellular calcium-dependent photoreceptor deactivation and rapid desensitization (1991) (186)
- Signal transduction in Drosophila photoreceptors. (1995) (186)
- Cytosolic calcium transients: Spatial localization and role in drosophila photoreceptor cell function (1994) (138)
- Allosteric determinants in guanine nucleotide-binding proteins (2003) (133)
- Electric-field-stimulated protein mechanics (2016) (131)
- An evolution-based model for designing chorismate mutase enzymes (2020) (131)
- An interdomain sector mediating allostery in Hsp70 molecular chaperones (2010) (126)
- Overview of the Alliance for Cellular Signaling (2002) (125)
- Signal transduction pathway of TonB-dependent transporters (2007) (107)
- Dynamic Scaffolding in a G Protein-Coupled Signaling System (2007) (105)
- Origins of Allostery and Evolvability in Proteins: A Case Study (2016) (103)
- Evolution-Based Functional Decomposition of Proteins (2015) (97)
- Knowledge-based potentials in protein design. (2006) (84)
- The Context-Dependence of Mutations: A Linkage of Formalisms (2015) (83)
- Coevolution-based inference of amino acid interactions underlying protein function (2018) (83)
- Learning the pattern of epistasis linking genotype and phenotype in a protein (2017) (82)
- Deconstruction of the Ras switching cycle through saturation mutagenesis (2017) (78)
- Knowledge-based potential functions in protein design. (2002) (74)
- A novel allosteric mechanism in the cysteine peptidase cathepsin K discovered by computational methods (2014) (70)
- An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor (2016) (65)
- An evolutionary hotspot defines functional differences between CRYPTOCHROMES (2018) (65)
- Rediscovering the power of pairwise interactions (2007) (64)
- Arrestin binding determines the rate of inactivation of the G protein-coupled receptor rhodopsin in vivo (1995) (61)
- The molecular genetics of invertebrate phototransduction (1991) (57)
- Local complexity of amino acid interactions in a protein core (2003) (42)
- Elevated basal slippage mutation rates among the Canidae. (2007) (37)
- Systems analysis of the single photon response in invertebrate photoreceptors (2008) (34)
- Evolution-based design of proteins. (2013) (33)
- Evolvability as a Function of Purifying Selection in TEM-1 b-Lactamase Graphical Abstract Highlights (2015) (32)
- Autophagy: Snapshot of the network (2010) (29)
- A Matter of Life or Death (2003) (25)
- Evolutionary origins of ion channels. (1994) (24)
- Quantifying the Rhythm of KaiB-C Interaction for In Vitro Cyanobacterial Circadian Clock (2012) (21)
- Neuronal Fibrillar Cytoskeleton and Endomembrane System Organization in Alzheimer’s Disease (1987) (20)
- Signaling Across the Cell Membrane (2007) (18)
- 100th Anniversary of Macromolecular Science Viewpoint: Data-Driven Protein Design. (2021) (18)
- Hierarchical organization endows the kinase domain with regulatory plasticity (2017) (15)
- Roadmap on biology in time varying environments (2021) (13)
- RNA sectors and allosteric function within the ribosome (2020) (9)
- Cell biology. A matter of life or death. (2003) (8)
- Erratum: Evolutionarily conserved networks of residues mediate allosteric communication in proteins (Nature Structural Biology (2003) 10 (59-69)) (2003) (8)
- Note 109 : A summary of SCA calculations (2012) (8)
- Evolution-based design of chorismate mutase enzymes (2020) (6)
- A Protocol for Functional Assessment of Whole-Protein Saturation Mutagenesis Libraries Utilizing High-Throughput Sequencing. (2016) (5)
- The relation between alignment covariance and background-averaged epistasis (2017) (5)
- Coevolution-based inference of amino acid interactions underlying 3 protein function 4 5 6 (4)
- Putting Evolution to Work (2018) (4)
- A Study on Verbalism among Visually Impaired Children in Andhra Pradesh (2014) (4)
- Undersampling and the inference of coevolution in proteins (2021) (2)
- A set of experimentally validated, mutually orthogonal primers for combinatorially specifying genetic components (2018) (2)
- Author response: Coevolution-based inference of amino acid interactions underlying protein function (2018) (1)
- On the Emergence of Single Versus Multi-State Allostery (2021) (1)
- Kernel mechanism of the cyanobacterial circadian clock is a relaxation oscillator (2011) (1)
- Theory Protein Sectors : Evolutionary Units of Three-Dimensional Structure (2009) (1)
- Author response: Deconstruction of the Ras switching cycle through saturation mutagenesis (2017) (1)
- Systems-level characterization of the kernel mechanism of the cyanobacterial circadian oscillator (2014) (1)
- S65T Q80R Green Fluorescent Protein (GFP) pH 5.5 (2004) (0)
- CC45, An Artificial WW Domain Designed Using Statistical Coupling Analysis (2005) (0)
- Inferring protein dynamics through experiment and simulation: collective modes from atomic trajectories (2019) (0)
- Author response: An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor (2016) (0)
- EF-X in Silico - Modeling Protein Dynamics in an Electric Field (2020) (0)
- Crystal Structure of the 5th PDZ domain of InaD (2007) (0)
- Title An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor (2016) (0)
- Innovations in electric field-stimulated X-ray crystallography (2021) (0)
- Deciphering evolutionary instructions for specifying protein fold and function (2011) (0)
- A mechanism for the evolution of allosteric control in proteins (2011) (0)
- The 5th PDZ Domain of InaD in 10mM DTT (2007) (0)
- S65T Q80R T203C Green Fluorescent Protein (GFP) pH 5.5 (2004) (0)
- The second PDZ domain of Ligand of Numb protein X 2 in the presence of an electric field of ~1 MV/cm along the crystallographic x axis, with eightfold extrapolation of structure factor differences. (2016) (0)
- The third PDZ domain from the synaptic protein PSD-95 (G330T, H372A double mutant) (2016) (0)
- The Heterogeneity of Mutational Tolerance in a Protein is Dependent on the Strength of Selective Pressure Correlating with Sectors of Co-evolving Residues (2011) (0)
- TEN Evolution-Based Design of Proteins (2014) (0)
- PIN1 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FROM HOMO SAPIENS (1998) (0)
- S65T Q80R Green Fluorescent Protein (GFP) pH 8.5 (2004) (0)
- Inferring amino acid interactions underlying protein function (2017) (0)
- The third PDZ domain from the synaptic protein PSD-95 (G330T mutant) (2016) (0)
- Analysis of electric-field stimulated time-resolved X-ray crystallography data (2019) (0)
- PDZ2 of LNX2 at 277K,single conformer model (2016) (0)
- Second PDZ domain of Ligand of Numb protein X 2 by Laue crystallography (no electric field) (2016) (0)
- C60-1, a PDZ domain designed using statistical coupling analysis (2008) (0)
- Crystal Structure of the C645S Mutant of the 5th PDZ Domain of InaD (2007) (0)
- Decision letter: ASPEN, a methodology for reconstructing protein evolution with improved accuracy using ensemble models (2019) (0)
- RED FLUORESCENT PROTEIN (FP583 OR DSRED(CLONTECH)) FROM DISCOSOMA SP. (2000) (0)
- InaD PDZs 4-5 Act as an Allosterically-Regulated Dynamic Scaffold (2011) (0)
- Novel Simulation Methods for Electric Field-Induced Dynamics of Protein Crystals (2020) (0)
- S65T Q80R Y145C T203C Green Fluorescent Protein (GFP) pH 8.5 (2004) (0)
- PDZ2 of LNX2 at 277K, model with alternate conformations (2016) (0)
- The Evolutionary Design of Proteins (2011) (0)
- Control of Enzyme Activity by a Light-Sensing Signaling Domain (2011) (0)
- Alfred Goodman Gilman (1941–2015) (2016) (0)
- Supplementary Information for A (2008) (0)
- Decision letter: Evolutionary and functional insights into the mechanism underlying body-size-related adaptation of mammalian hemoglobin (2019) (0)
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