Raphael Mechoulam

Raphael Mechoulam's AcademicInfluence.com Rankings

Raphael Mechoulam

Chemistry

#135

World Rank

#306

Historical Rank

Organic Chemistry

#76

World Rank

#107

Historical Rank

chemistry Degrees

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Chemistry

Why Is Raphael Mechoulam Influential?

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According to Wikipedia, Raphael Mechoulam was a Bulgarian-born Israeli organic chemist and a professor in the Department of Natural Materials at the School of Pharmacy in the Faculty of Medicine of the Hebrew University of Jerusalem. Mechoulam served as Rector of the university from 1979-1982. He was elected to the Israel Academy of Sciences and Humanities in 1994 and served as its scientific chair from 2007-2013. He was a recipient of the Israel Prize for Chemistry Research in 2000 and the Harvey Prize for 2019-2020.

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Raphael Mechoulam's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Isolation and structure of a brain constituent that binds to the cannabinoid receptor. (1992) (5259)
Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. (1995) (2730)
International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors (2002) (2552)
Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish (1964) (2158)
International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2 (2010) (1504)
Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide (2001) (964)
The endocannabinoid system and the brain. (2013) (834)
2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor (2001) (785)
An endogenous cannabinoid (2-AG) is neuroprotective after brain injury (2001) (723)
Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb. (2009) (691)
The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis. (2000) (565)
HU-308: a specific agonist for CB(2), a peripheral cannabinoid receptor. (1999) (539)
An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity. (1998) (513)
Endocannabinoid signaling at the periphery: 50 years after THC. (2015) (498)
Peripheral cannabinoid receptor, CB2, regulates bone mass. (2006) (498)
Chronic administration of cannabidiol to healthy volunteers and epileptic patients. (1980) (492)
Pharmacological activity of the cannabinoid receptor agonist, anandamide, a brain constituent. (1993) (446)
Cannabidiol – Recent Advances (2007) (445)
Cannabidiol: An Overview of Some Pharmacological Aspects (2002) (406)
The pharmacological activity of anandamide, a putative endogenous cannabinoid, in mice. (1994) (396)
Is lipid signaling through cannabinoid 2 receptors part of a protective system? (2011) (396)
Behavioral, biochemical, and molecular modeling evaluations of cannabinoid analogs (1991) (395)
Cannabidiol Attenuates Cardiac Dysfunction, Oxidative Stress, Fibrosis, Inflammatory and Cell Death Signaling Pathways in Diabetic Cardiomyopathy (2010) (374)
Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: Relevance to Parkinson's disease (2005) (349)
Cytokine production in the brain following closed head injury: dexanabinol (HU-211) is a novel TNF-α inhibitor and an effective neuroprotectant (1997) (333)
The isolation and structure of delta-1-tetrahydrocannabinol and other neutral cannabinoids from hashish. (1971) (330)
Hashish. I. The structure of cannabidiol. (1963) (325)
Two new unsaturated fatty acid ethanolamides in brain that bind to the cannabinoid receptor. (1993) (321)
A TOTAL SYNTHESIS OF DL-DELTA-1-TETRAHYDROCANNABINOL, THE ACTIVE CONSTITUENT OF HASHISH. (1965) (304)
Chemical Basis of Hashish Activity (1970) (302)
Anandamide, a Brain Endogenous Compound, Interacts Specifically with Cannabinoid Receptors and Inhibits Adenylate Cyclase (1993) (290)
Cannabidiol and Other Cannabinoids Reduce Microglial Activation In Vitro and In Vivo: Relevance to Alzheimer's Disease (2011) (290)
Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson's disease: Importance of antioxidant and cannabinoid receptor-independent properties (2007) (269)
Attenuation of Allergic Contact Dermatitis Through the Endocannabinoid System (2007) (264)
Early phytocannabinoid chemistry to endocannabinoids and beyond (2014) (264)
Structural requirements for binding of anandamide-type compounds to the brain cannabinoid receptor. (1997) (259)
Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid? (2013) (254)
Biphasic Effects of Anandamide (1998) (248)
Human brain endothelium: coexpression and function of vanilloid and endocannabinoid receptors. (2004) (242)
Antipsychotic effect of cannabidiol. (1995) (239)
Cannabinoids and brain injury: therapeutic implications. (2002) (234)
A historical overview of chemical research on cannabinoids. (2000) (228)
Low dose anandamide affects food intake, cognitive function, neurotransmitter and corticosterone levels in diet-restricted mice. (2000) (227)
Non‐psychoactive CB2 cannabinoid agonists stimulate neural progenitor proliferation (2006) (221)
Cannabidiol-transdermal delivery and anti-inflammatory effect in a murine model. (2003) (219)
The peripheral cannabinoid receptor: adenylate cyclase inhibition and G protein coupling (1995) (211)
Cannabidiol, a non‐psychotropic component of cannabis, attenuates vomiting and nausea‐like behaviour via indirect agonism of 5‐HT1A somatodendritic autoreceptors in the dorsal raphe nucleus (2012) (197)
Discovery and characterization of endogenous cannabinoids. (1999) (193)
Presence of functional cannabinoid receptors in human endocrine pancreas (2008) (192)
The endocannabinoid 2-AG protects the blood–brain barrier after closed head injury and inhibits mRNA expression of proinflammatory cytokines (2006) (189)
Cannabidiol: an overview of some chemical and pharmacological aspects. Part I: chemical aspects. (2002) (184)
Suppressors of cancer cell proliferation from fig (Ficus carica) resin: isolation and structure elucidation. (2001) (183)
Tetrahydrocannabinol and endocannabinoids in feeding and appetite. (2002) (183)
Effect of the brain constituent anandamide, a cannabinoid receptor agonist, on the hypothalamo-pituitary-adrenal axis in the rat. (1994) (180)
Cannabinoids in health and disease (2007) (177)
A novel probe for the cannabinoid receptor. (1992) (176)
Cannabinoid CB2 receptor agonists protect the striatum against malonate toxicity: Relevance for Huntington's disease (2009) (176)
The absolute configuration of δ1-tetrahydrocannabinol, the major active constituent of hashish. (1967) (175)
Nonpsychotropic cannabinoid acts as a functional N-methyl-D-aspartate receptor blocker. (1989) (173)
N-arachidonoyl l-serine, an endocannabinoid-like brain constituent with vasodilatory properties (2006) (172)
The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling (2008) (172)
Anandamide may mediate sleep induction (1997) (170)
2-Arachidonylglycerol, an endogenous cannabinoid, inhibits tumor necrosis factor-alpha production in murine macrophages, and in mice. (2000) (170)
Anandamide (arachidonylethanolamide), a brain cannabinoid receptor agonist, reduces sperm fertilizing capacity in sea urchins by inhibiting the acrosome reaction. (1994) (169)
Recent advances in the chemistry and biochemistry of cannabis (1976) (167)
Hashish. IV. The isolation and structure of cannabinolic cannabidiolic and cannabigerolic acids. (1965) (166)
First direct evidence for the mechanism of .DELTA.1-tetrahydrocannabinolic acid biosynthesis (1995) (163)
Cannabidiol lowers incidence of diabetes in non-obese diabetic mice (2006) (163)
An efficient new cannabinoid antiemetic in pediatric oncology. (1995) (160)
Cannabinol derivatives: binding to cannabinoid receptors and inhibition of adenylylcyclase. (1997) (160)
Inhibitory effects of certain enantiomeric cannabinoids in the mouse vas deferens and the myenteric plexus preparation of guinea‐pig small intestine (1992) (153)
Preliminary, Open-Label, Pilot Study of Add-On Oral Δ9-Tetrahydrocannabinol in Chronic Post-Traumatic Stress Disorder (2014) (151)
CB1 cannabinoid receptors are involved in neuroprotection via NF-κB inhibition (2005) (150)
()--Tetrahydrocannabinol Antagonizes the Peripheral Cannabinoid Receptor-mediated Inhibition of Adenylyl Cyclase (*) (1996) (150)
Cannabidiol protects against hepatic ischemia/reperfusion injury by attenuating inflammatory signaling and response, oxidative/nitrative stress, and cell death (2011) (149)
Marihuana chemistry. (1970) (145)
Effect of low doses of Δ9-tetrahydrocannabinol and cannabidiol on the extinction of cocaine-induced and amphetamine-induced conditioned place preference learning in rats (2004) (145)
Recent advances in the chemistry of hashish. (1967) (144)
Prospective analysis of safety and efficacy of medical cannabis in large unselected population of patients with cancer. (2018) (142)
Endocannabinoids and Neuroprotection (2002) (142)
Cannabinoids: influence on neurotransmitter uptake in rat brain synaptosomes. (1975) (142)
Effects of cannabidiol on behavioral seizures caused by convulsant drugs or current in mice. (1982) (141)
Endocannabinoids and Traumatic Brain Injury (2007) (141)
Early medical use of cannabis (1993) (140)
Incensole acetate, an incense component, elicits psychoactivity by activating TRPV3 channels in the brain (2008) (140)
Involvement of Neuronal Cannabinoid Receptor CB1 in Regulation of Bone Mass and Bone Remodeling (2006) (140)
The CB(2) cannabinoid receptor controls myeloid progenitor trafficking: involvement in the pathogenesis of an animal model of multiple sclerosis. (2008) (139)
Epidemiological characteristics, safety and efficacy of medical cannabis in the elderly. (2018) (138)
Effect of cannabinoids on lithium-induced vomiting in the Suncus murinus (house musk shrew) (2003) (135)
Milk intake and survival in newborn cannabinoid CB1 receptor knockout mice: evidence for a "CB3" receptor. (2003) (135)
Suppression of experimental autoimmune encephalomyelitis by cannabinoids. (1994) (134)
Cannabidiol reduced the striatal atrophy caused 3‐nitropropionic acid in vivo by mechanisms independent of the activation of cannabinoid, vanilloid TRPV1 and adenosine A2A receptors (2007) (134)
Inhibition of Human Neutrophil Chemotaxis by Endogenous Cannabinoids and Phytocannabinoids: Evidence for a Site Distinct from CB1 and CB2 (2008) (132)
Enantiomeric cannabinoids: stereospecificity of psychotropic activity (1988) (129)
Cannabinoids Induce Glioma Stem-like Cell Differentiation and Inhibit Gliomagenesis* (2007) (128)
A nonpsychotropic cannabinoid, HU-211, has cerebroprotective effects after closed head injury in the rat. (1993) (127)
Search for endogenous ligands of the cannabinoid receptor. (1994) (127)
A novel synthetic, nonpsychoactive cannabinoid acid (HU-320) with antiinflammatory properties in murine collagen-induced arthritis. (2004) (126)
Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines. (2010) (126)
Noladin ether, a putative novel endocannabinoid: inactivation mechanisms and a sensitive method for its quantification in rat tissues (2002) (125)
Cannabidiol presents an inverted U-shaped dose-response curve in a simulated public speaking test (2018) (124)
A comparative analysis of the potential of cannabinoids and ondansetron to suppress cisplatin-induced emesis in the Suncus murinus (house musk shrew) (2004) (123)
Effects of THC on driving performance, physiological state and subjective feelings relative to alcohol. (2008) (122)
Stereochemical effects of 11-OH-Δ 8-tetrahydrocannabinol-dimethylheptyl to inhibit adenylate cyclase and bind to the cannabinoid receptor (1990) (121)
Critical role of the endogenous cannabinoid system in mouse pup suckling and growth. (2001) (121)
Drug-Induced Hypothermia Reduces Ischemic Damage: Effects of the Cannabinoid HU-210 (2003) (121)
Cannabidiol protects oligodendrocyte progenitor cells from inflammation-induced apoptosis by attenuating endoplasmic reticulum stress (2012) (119)
From gan-zi-gun-nu to anandamide and 2-arachidonoylglycerol: the ongoing story of cannabis. (1999) (117)
Cannabidiol arrests onset of autoimmune diabetes in NOD mice (2008) (117)
Trick or treat from food endocannabinoids? (1998) (113)
CB1 cannabinoid receptors are involved in neuroprotection via NF-kappa B inhibition. (2005) (112)
Short-term fasting and prolonged semistarvation have opposite effects on 2-AG levels in mouse brain (2003) (112)
Toward drugs derived from cannabis (2004) (112)
Cannabinoids: between neuroprotection and neurotoxicity. (2005) (111)
Carbachol, an acetylcholine receptor agonist, enhances production in rat aorta of 2-arachidonoyl glycerol, a hypotensive endocannabinoid. (1998) (110)
A stereospecific synthesis of (-)-delta 1- and (-)-delta 1(6)-tetrahydrocannabinols. (1967) (108)
Marijuana ; chemistry, pharmacology, metabolism and clinical effects (1973) (108)
Cannabidiol ameliorates cognitive and motor impairments in bile‐duct ligated mice via 5‐HT1A receptor activation (2010) (107)
Plant cannabinoids: a neglected pharmacological treasure trove (2005) (105)
Endocannabinoids and traumatic brain injury (2011) (103)
Cannabidiol Protects against Doxorubicin-Induced Cardiomyopathy by Modulating Mitochondrial Function and Biogenesis (2015) (103)
Cannabidiol, a non‐psychoactive component of cannabis and its synthetic dimethylheptyl homolog suppress nausea in an experimental model with rats (2002) (103)
Prospects for cannabinoid therapies in basal ganglia disorders (2011) (102)
Cannabinoids and endocannabinoids in metabolic disorders with focus on diabetes. (2011) (101)
Stereochemical effects of 11-OH-Δ 8-THC-dimethylheptyl in mice and dogs (1989) (99)
Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats (2006) (99)
A new cannabinoid CB2 receptor agonist HU‐910 attenuates oxidative stress, inflammation and cell death associated with hepatic ischaemia/reperfusion injury (2012) (98)
Cannabidiol, a nonpsychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury. (2007) (97)
Synthesis of the individual, pharmacologically distinct, enantiomers of a tetrahydrocannabinol derivative (1990) (91)
DOMESTICATION OF PLANTS IN THE OLD WORLD: THE ORIGIN AND SPREAD OF CULTIVATED PLANTS IN WEST ASIA, EUROPE AND THE NILE VALLEY. Daniel Zohary and Maria Hopf. 2000. 3rd edition. Oxford University Press, Oxford. 316 pp. Hardcover, £22.95. ISBN 0-19850-356-3. (2002) (91)
Effects of cannabinoids on lithium-induced conditioned rejection reactions in a rat model of nausea (2003) (89)
Cannabidiol improves brain and liver function in a fulminant hepatic failure‐induced model of hepatic encephalopathy in mice (2011) (88)
Syntheses of .DELTA.1-tetrahydrocannabinol and related cannabinoids (1972) (88)
Hashish—VII : The isomerization of cannabidiol to tetrahydrocannabinols (1966) (87)
Synthetic nonpsychotropic cannabinoids with potent antiinflammatory, analgesic, and leukocyte antiadhesion activities. (1992) (86)
Administration of 2-arachidonoylglycerol ameliorates both acute and chronic experimental autoimmune encephalomyelitis (2011) (86)
Cannabidiol ameliorates cognitive and motor impairments in mice with bile duct ligation. (2009) (84)
STRUCTURAL REQUIREMENTS FOR CANNABINOID ACTIVITY * (1971) (84)
Metabolites of cannabidiol identified in human urine. (1990) (83)
Boswellia resin: from religious ceremonies to medical uses; a review of in‐vitro, in‐vivo and clinical trials (2009) (82)
Real life Experience of Medical Cannabis Treatment in Autism: Analysis of Safety and Efficacy (2019) (81)
Cannabichromene, a new active principle in hashish (1966) (80)
Synthesis and antitumor activity of quinonoid derivatives of cannabinoids. (2004) (79)
The absolute configuration of delta-1-tetrahydrocannabinol, the major active constituent of hashish. (1967) (78)
Discovery of endocannabinoids and some random thoughts on their possible roles in neuroprotection and aggression. (2002) (77)
The effect of cannabidiol and URB597 on conditioned gaping (a model of nausea) elicited by a lithium-paired context in the rat (2008) (77)
Incensole Acetate, a Novel Anti-Inflammatory Compound Isolated from Boswellia Resin, Inhibits Nuclear Factor-κB Activation (2007) (77)
Low doses of anandamides inhibit pharmacological effects of delta 9-tetrahydrocannabinol. (1995) (76)
Differential response to acute and repeated stress in cannabinoid CB1 receptor knockout newborn and adult mice (2005) (76)
Pharmacological effects of two active constituents of marihuana. (1968) (75)
Boswellia resin: from religious ceremonies to medical uses; a review of in-vitro, in-vivo and clinical trials. (2009) (74)
Beyond THC and Endocannabinoids. (2020) (73)
Cannabidiol attenuates alcohol-induced liver steatosis, metabolic dysregulation, inflammation and neutrophil-mediated injury (2017) (72)
Incensole Acetate: A Novel Neuroprotective Agent Isolated from Boswellia Carterii (2008) (72)
Towards cannabinoid drugs--revisited. (1998) (72)
Interaction between non-psychotropic cannabinoids in marihuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews (2011) (71)
Oleoyl serine, an endogenous N-acyl amide, modulates bone remodeling and mass (2010) (71)
Anxiolytic effect of cannabidiol derivatives in the elevated plus-maze. (1994) (70)
The chemistry of endocannabinoids. (2006) (70)
Stout Guards of the Central Nervous System (2003) (70)
Protection against septic shock and suppression of tumor necrosis factor alpha and nitric oxide production by dexanabinol (HU-211), a nonpsychotropic cannabinoid. (1997) (70)
A Cannabinoid Quinone Inhibits Angiogenesis by Targeting Vascular Endothelial Cells (2006) (69)
Prohedonic Effect of Cannabidiol in a Rat Model of Depression (2016) (69)
Human Brain Capillary Endothelium: 2-Arachidonoglycerol (Endocannabinoid) Interacts With Endothelin-1 (2000) (67)
CB2 Cannabinoid Receptor Targets Mitogenic Gi Protein–Cyclin D1 Axis in Osteoblasts (2010) (67)
Up-regulation of the endocannabinoid system in the uterus of leptin knockout (ob/ob) mice and implications for fertility. (2005) (66)
Cannabis and alcohol--a close friendship. (2003) (66)
Pharmacokinetics of cannabidiol in dogs. (1988) (65)
Enantiomeric cannabidiol derivatives: synthesis and binding to cannabinoid receptors. (2005) (64)
Cannabinomimetic behavioral effects of and adenylate cyclase inhibition by two new endogenous anandamides. (1995) (64)
Delta-9-tetrahydrocannabinol and cannabidiol, but not ondansetron, interfere with conditioned retching reactions elicited by a lithium-paired context in Suncus murinus: An animal model of anticipatory nausea and vomiting (2006) (64)
The sleep inducing factor oleamide is produced by mouse neuroblastoma cells. (1997) (63)
A study investigating the acute dose— response effects of 13 mg and 17 mg Δ 9- tetrahydrocannabinol on cognitive—motor skills, subjective and autonomic measures in regular users of marijuana (2008) (62)
γ-Irradiation Enhances Apoptosis Induced by Cannabidiol, a Non-psychotropic Cannabinoid, in Cultured HL-60 Myeloblastic Leukemia Cells (2003) (62)
Cannabidiol, a Major Non‐Psychotropic Cannabis Constituent Enhances Fracture Healing and Stimulates Lysyl Hydroxylase Activity in Osteoblasts (2015) (61)
Effects of two endogenous fatty acid ethanolamides on mouse vasa deferentia. (1994) (61)
Endocannabinoids affect neurological and cognitive function in thioacetamide-induced hepatic encephalopathy in mice (2006) (60)
Cannabinoids as therapeutics. (2005) (59)
Motor effects of the non-psychotropic phytocannabinoid cannabidiol that are mediated by 5-HT1A receptors (2013) (58)
Blockade of45Ca2+ influx through theN-methyl-d-aspartate receptor ion channel by the non-psychoactive cannabinoid HU-211 (1993) (58)
Characterization of the hypothermic effect of the synthetic cannabinoid HU-210 in the rat. Relation to the adrenergic system and endogenous pyrogens (1995) (58)
The cannabinoids: an overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection. (2001) (57)
Inhibition of cisplatin-induced emesis in the pigeon by a non-psychotropic synthetic cannabinoid. (1989) (56)
HDAC1 and HDAC3 underlie dynamic H3K9 acetylation during embryonic neurogenesis and in schizophrenia‐like animals (2018) (56)
Inhibition of monoacylglycerol lipase attenuates vomiting in Suncus murinus and 2‐arachidonoyl glycerol attenuates nausea in rats (2012) (55)
Cannabidiol for the Prevention of Graft-versus-Host-Disease after Allogeneic Hematopoietic Cell Transplantation: Results of a Phase II Study. (2015) (55)
Comparative metabolism of cannabidiol in dog, rat and man (1991) (55)
Physiology: A hunger for cannabinoids (2001) (54)
(+)-Cannabidiol analogues which bind cannabinoid receptors but exert peripheral activity only. (2004) (52)
In vitro and in vivo efficacy of non-psychoactive cannabidiol in neuroblastoma. (2016) (52)
Comparison of the enzymatic stability and intraocular pressure effects of 2-arachidonylglycerol and noladin ether, a novel putative endocannabinoid. (2002) (52)
HU-331, a novel cannabinoid-based anticancer topoisomerase II inhibitor (2007) (52)
Cannabielsoic acids : Isolation and synthesis by a novel oxidative cyclization (1974) (51)
Cannabinoid agonists and antagonists modulate lithium-induced conditioned gaping in rats (2003) (51)
Novel natural and synthetic ligands of the endocannabinoid system. (2010) (50)
Endogenous cannabinoid ligands--chemical and biological studies. (1996) (50)
Effects on sleep and dopamine levels of microdialysis perfusion of cannabidiol into the lateral hypothalamus of rats. (2011) (50)
The non-psychotropic cannabinoid (+)-(3S,4S)-7-hydroxy-Δ 6-tetrahydrocannabinol 1,1-dimethylheptyl (HU-211) attenuates N-methyl-d-aspartate receptor-mediated neurotoxicity in primary cultures of rat forebrain (1993) (50)
Brain imaging study of the acute effects of Δ9-tetrahydrocannabinol (THC) on attention and motor coordination in regular users of marijuana (2007) (50)
Developmental aspects of anandamide: ontogeny of response and prenatal exposure (1996) (50)
N-Arachidonoyl-l-Serine is Neuroprotective after Traumatic Brain Injury by Reducing Apoptosis (2011) (50)
Hashish components. Photochemical production of cannabicyclol from cannabichromene. (1968) (49)
Identification through synthesis of an active delta-1(6)-tetrahydrocannabinol metabolite. (1970) (49)
Peripubertal cannabidiol treatment rescues behavioral and neurochemical abnormalities in the MAM model of schizophrenia (2019) (49)
The anti‐nausea effects of CB1 agonists are mediated by an action at the visceral insular cortex (2012) (49)
Metabolism of Δ1(6)-Tetrahydro-cannabinol, an Active Marihuana Constituent (1970) (48)
Cannabis--a valuable drug that deserves better treatment. (2012) (48)
N‐Acyl amino acids and their impact on biological processes (2014) (47)
Cannabidiol Limits T Cell-Mediated Chronic Autoimmune Myocarditis: Implications to Autoimmune Disorders and Organ Transplantation (2016) (47)
Repeated stimulation of D1 dopamine receptors enhances (-)-11-hydroxy-delta 8-tetrahydrocannabinol-dimethyl-heptyl-induced catalepsy in male rats. (1994) (47)
Cannabinoids ameliorate cerebral dysfunction following liver failure via AMP‐activated protein kinase (2007) (47)
Chemistry of Cannabis (1982) (46)
Ontogenetic development of the response to anandamide and Δ9-tetrahydrocannabinol in mice (1996) (46)
Synthesis and biological activity of five tetrahydrocannabinol metabolites. (1972) (46)
Effect of prior foot shock stress and Δ9-tetrahydrocannabinol, cannabidiolic acid, and cannabidiol on anxiety-like responding in the light-dark emergence test in rats (2017) (46)
Effects of cannabidiol in males and females in two different rat models of depression (2019) (45)
Δ9-Tetrahydrocannabinol inhibits cell cycle progression by downregulation of E2F1 in human glioblastoma multiforme cells (2008) (45)
Endothelial-mediated regulation of cerebral microcirculation. (2006) (45)
Suppression of neuropathic pain behavior in rats by a non-psychotropic synthetic cannabinoid with NMDA receptor-blocking properties (1991) (45)
A new tetrahydrocannabinolic acid. (1969) (45)
Stereochemical requirements for cannabinoid activity. (1980) (44)
Anticonvulsant effects of the (-) and (+)isomers of cannabidiol and their dimethylheptyl homologs. (1982) (44)
A Cannabinoid Anticancer Quinone, HU-331, Is More Potent and Less Cardiotoxic Than Doxorubicin: A Comparative in Vivo Study (2007) (43)
Synthesis of Steroidal Methylene Compounds by the Wittig Reaction1 (1957) (43)
Omega-3 N-acylethanolamines are endogenously synthesised from omega-3 fatty acids in different human prostate and breast cancer cell lines. (2011) (43)
Hashish--13. On the nature of the Beam test. (1968) (42)
Stereospecificity of the discriminative stimulus functions of the dimethylheptyl homologs of 11-hydroxy-delta 8-tetrahydrocannabinol in rats and pigeons. (1989) (42)
CB2 cannabinoid receptor agonist enantiomers HU-433 and HU-308: An inverse relationship between binding affinity and biological potency (2015) (42)
Endocannabinoids as positive or negative factors in hematopoietic cell migration and differentiation. (2008) (41)
Stereoelectronic factor in the chloranil dehydrogenation of cannabinoids. Total synthesis of dl-cannabichromene. (1968) (41)
The Jerusalem Balsam: from the Franciscan Monastery in the old city of Jerusalem to Martindale 33. (2005) (41)
Dexanabinol (HU‐211): A nonpsychotropic cannabinoid with neuroprotective properties (2000) (41)
Cannabinoids and Capsaicin Improve Liver Function Following Thioacetamide-Induced Acute Injury in Mice (2008) (41)
Estrogens in insects (1984) (41)
Boron trifluoride etherate on alumina ― a modified Lewis acid reagent. An improved synthesis of cannabidiol (1985) (40)
The Pharmacohistory of Cannabis Sativa (2019) (40)
Effects of the endocannabinoid noladin ether on body weight, food consumption, locomotor activity, and cognitive index in mice (2005) (40)
A random walk through a cannabis field (1991) (39)
Additions and Corrections - A Total Synthesis of dl-Δ'-Tetrahydrocannabinol, the Active Constituent of Hashish. (1965) (39)
A submicron emulsion of HU-211, a synthetic cannabinoid, reduces intraocular pressure in rabbits (2000) (38)
The Wittig Reaction with Fluorenone. Formation of Cyclopropane Derivatives (1958) (38)
Identification of 5α-Androstane-3α, 17β-diol as a Principal Metabolite of Pregnenolone in Rat Ovary at Onset of Puberty (1970) (38)
Syntheses in the Cardiac Aglycone Field. III.1 The Conversion of a 14α- to a 14β-Hydroxy Group in the Androstane Series. The Ultraviolet Spectra of Δ15-Androsten-17-ones (1960) (37)
Cannabidiolic acid methyl ester, a stable synthetic analogue of cannabidiolic acid, can produce 5‐HT1A receptor‐mediated suppression of nausea and anxiety in rats (2018) (37)
PADMA-28, a traditional tibetan herbal preparation inhibits the respiratory burst in human neutrophils, the killing of epithelial cells by mixtures of oxidants and pro-inflammatory agonists and peroxidation of lipids (1999) (37)
Anticonvulsant activity of four oxygenated cannabidiol derivatives. (1975) (37)
N-arachidonoyl-L-serine (AraS) Possesses Proneurogenic Properties in Vitro and in Vivo after Traumatic Brain Injury (2013) (36)
Therapeutic opportunities through modulation of the endocannabinoid system (2005) (36)
Towards cannabinoid drugs. (1987) (36)
The nonpsychoactive Cannabis constituent cannabidiol is a wake-inducing agent. (2008) (35)
Endocannabinoid signaling in neurotoxicity and neuroprotection. (2010) (33)
Fluorinated Cannabidiol Derivatives: Enhancement of Activity in Mice Models Predictive of Anxiolytic, Antidepressant and Antipsychotic Effects (2016) (32)
Toward an anandamide transporter. (2005) (32)
Carboxylation of resorcinols with methylmagnesium carbonate. Synthesis of cannabinoid acids (1969) (31)
Skeletal lipidomics: regulation of bone metabolism by fatty acid amide family (2011) (31)
Evidence that (−)-7-hydroxy-4′-dimethylheptyl-cannabidiol activates a non-CB1, non-CB2, non-TRPV1 target in the mouse vas deferens (2005) (31)
Capsaicin affects brain function in a model of hepatic encephalopathy associated with fulminant hepatic failure in mice (2009) (31)
Stereochemical requirements for cannabimimetic activity. (1987) (30)
The CB1 cannabinoid receptor agonist, HU-210, reduces levodopa-induced rotations in 6-hydroxydopamine-lesioned rats. (2003) (30)
Endocannabinoids, feeding and suckling – from our perspective (2006) (30)
Stereospecific effects of (-)- and (+)-7-hydroxy-delta-6-tetrahydrocannabinol-dimethylheptyl on the immune system of mice. (1989) (30)
Looking back at Cannabis research. (2000) (30)
The ISO‐Tetrahydrocannabinols (1968) (29)
The CB2 Cannabinoid Receptor Controls Myeloid Progenitor Trafficking (2008) (29)
Altered dopamine D3 receptor gene expression in MAM model of schizophrenia is reversed by peripubertal cannabidiol treatment. (2020) (29)
RECENT ADVANCES IN THE USE OF CANNABINOIDS AS THERAPEUTIC AGENTS (1984) (29)
N-Oleoyl-glycine reduces nicotine reward and withdrawal in mice (2019) (29)
Cannabis – the Israeli perspective (2016) (28)
A total synthesis of distamycin a, an antiviral antibiotic (1978) (28)
6β-Hydroxy-δ1-Tetrahydrocannabinol Synthesis and Biological Activity (1971) (28)
Anti-inflammatory effects of the cannabidiol derivative dimethylheptyl-cannabidiol – studies in BV-2 microglia and encephalitogenic T cells (2016) (27)
The synthetic cannabinoid HU-210 attenuates neural damage in diabetic mice and hyperglycemic pheochromocytoma PC12 cells (2007) (27)
CANNABINOID ENANTIOMER ACTION ON THE CYTOARCHITECTURE (1996) (27)
Recent Advantages in Cannabinoid Research (1999) (27)
Bioactive lipids ALIAmides differentially modulate inflammatory responses of distinct subsets of primary human T lymphocytes (2018) (27)
Halogenation of phenols and phenyl ethers with potassium halides in the presence of 18-crown-6 on oxidation with m-chloroperbenzoic acid (1987) (27)
Endogenous Cannabinoids Improve Myocardial Resistance to Arrhythmogenic Effects of Coronary Occlusion and Reperfusion: a Possible Mechanism (2002) (27)
Cannabidiol and phenytoin: a structural comparison. (1980) (26)
Cannabis and epilepsy (2017) (26)
Urinary metabolites of cannabidiol in dog, rat and man and their identification by gas chromatography-mass spectrometry. (1991) (25)
Antimicrobial potential of endocannabinoid and endocannabinoid-like compounds against methicillin-resistant Staphylococcus aureus (2018) (25)
Efficacy and Safety of Cannabidiol Plus Standard Care vs Standard Care Alone for the Treatment of Emotional Exhaustion and Burnout Among Frontline Health Care Workers During the COVID-19 Pandemic (2021) (25)
Effect of the synthetic cannabinoid HU-210 on quorum sensing and on the production of quorum sensing-mediated virulence factors by Vibrio harveyi (2015) (25)
HU‐446 and HU‐465, Derivatives of the Non‐psychoactive Cannabinoid Cannabidiol, Decrease the Activation of Encephalitogenic T Cells (2016) (25)
Towards a better cannabis drug (2013) (24)
Neuroscience. Stout guards of the central nervous system. (2003) (24)
Prospects for Creation of Cardioprotective Drugs Based on Cannabinoid Receptor Agonists (2016) (24)
Cannabimimetic activity (Δ 1-THC cue) of cannabidiol monomethyl ether and two stereoisomeric hexahydrocannabinols in rats and pigeons (1986) (24)
Dominant negative DISC1 mutant mice display specific social behaviour deficits and aberration in BDNF and cannabinoid receptor expression (2014) (23)
Photochemical reactions of cannabidiol (1971) (23)
Structure-activity relationships in the tetrahydrocannabinol series. Modifications on the aromatic ring and it the side-chain. (1972) (23)
Crosstalk between the transcriptional regulation of dopamine D2 and cannabinoid CB1 receptors in schizophrenia: Analyses in patients and in perinatal Δ9-tetrahydrocannabinol-exposed rats (2021) (23)
Further Aspects of the Wittig Reaction in the Steroid Series. 20-Dehydrocholesterol and 20-Isocholesterol (1958) (23)
Stereoselective cyclizations of cannabinoid 1,5 dienes. (1969) (23)
Base-catalysed double-bond isomerizations of cannabinoids: structural and stereochemical aspects (1984) (22)
Synthesis of a primary metabolite of cannabidiol. (2000) (22)
Resolution of chiral cannabinoids on amylose tris(3,5-dimethylphenylcarbamate) chiral stationary phase: effects of structural features and mobile phase additives. (1993) (22)
Role of CB2 Receptor in the Recovery of Mice after Traumatic Brain Injury. (2019) (21)
Structure-activity relationships of pyrrole amidine antiviral antibiotics. 2. Preparation of mono- and tripyrrole derivatives of congocidine. (1980) (21)
Concerning the Isomerization of Δ1-to Δ1(6)-Tetrahydrocannabinol1 (1966) (21)
Antinociceptive effects of HUF-101, a fluorinated cannabidiol derivative (2017) (20)
Interview with Prof. Raphael Mechoulam, codiscoverer of THC.. Interview by Stanley Einstein. (1986) (20)
Anti-Biofilm Activity of Cannabidiol against Candida albicans (2021) (20)
Acute oral cannabidiolic acid methyl ester reduces depression-like behavior in two genetic animal models of depression (2018) (20)
Endocannabinoids in liver disease and hepatic encephalopathy. (2008) (20)
Antioxidant properties of the vasoactive endocannabinoid, 2-arachidonoyl glycerol (2-AG). (2003) (19)
The synthesis of 10-hydroxy-10α-testosterone (1964) (19)
CB1 cannabinoid receptors mediate endochondral skeletal growth attenuation by Δ9‐tetrahydrocannabinol (2015) (19)
Total syntheses of cannabidiol and Δ1-tetrahydrocannabinol metabolites (1976) (19)
On the Therapeutic Possibilities of Some Cannabinoids (1976) (19)
Multiple sclerosis may disrupt endocannabinoid brain protection mechanism. (2006) (19)
HU-444, a Novel, Potent Anti-Inflammatory, Nonpsychotropic Cannabinoid (2015) (19)
Cannabidiol for COVID-19 Patients with Mild to Moderate Symptoms (CANDIDATE Study): A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. (2021) (18)
Reduction of hippocampal acetylcholine turnover in rats treated with (−)-Δ8-tetrahydrocannabinol and its 1′,2′-dimethyl-heptyl homolog (1980) (18)
The toxicity of Veratrum and Solanum alkaloids to housefly larvae (1958) (18)
Stereospecifically labeled delta1(6)-tetrahydrocannabinol. (1968) (18)
Subject Index, Vol. 39, 1989 (1989) (18)
Prostaglandins and cannabis XV. Comparison of enantiomeric cannabinoids in stimulating prostaglandin synthesis in fibroblasts. (1986) (18)
Activation of Cannabinoid Receptors Decreases the Area of Ischemic Myocardial Necrosis (2002) (18)
The synthesis of zapotidine. (1967) (17)
Structure--activity relationships of pyrrole amidine antiviral antibiotics. 1. Modifications of the alkylamidine side chain. (1979) (17)
Stereochemical effects of 11-OH-delta 8-THC-dimethylheptyl in mice and dogs. (1989) (17)
Synthesis and psychotropic activity of side-chain hydroxylated delta6-tetrahydrocannabinol metabolites. (1979) (17)
Structure-anticonvulsant activity relationships of cannabidiol analogs. (1987) (16)
Cannabimimetic activity of novel enantiomeric, benzofuran cannabinoids. (1990) (16)
A new type of cannabinoid. Synthesis of cannabielsoic acid A by a novel photo-oxidative cyclisation (1970) (16)
Cannabinoid Geometry and Biological Activity (2019) (16)
A repeated tests procedure to assess onset and duration of the cue properties of (−)Δ9-THC, (−)Δ8-THC-DMH and (+)Δ8-THC (1981) (16)
Potential combinations of endocannabinoid/endocannabinoid-like compounds and antibiotics against methicillin-resistant Staphylococcus aureus (2020) (15)
Endogenous and Synthetic Cannabinoids: Recent Advances (1996) (15)
An evaluation of the anti‐hyperalgesic effects of cannabidiolic acid‐methyl ester in a preclinical model of peripheral neuropathic pain (2020) (15)
THE STRUCTURE OF ZAPOTIDINE1 (1961) (15)
Ontogenetic development of the response to anandamide and delta 9-tetrahydrocannabinol in mice. (1996) (15)
PADMA-28, a traditional Tibetan herbal preparation, blocks cellular responses to bFGF and IGF-I (2004) (15)
Δ6-Tetrahydrocannabinol-7-oic acid, a urinary Δ6-THC metabolite: Isolation and synthesis (1973) (14)
Cannabinoids as Therapeutic Agents (2019) (14)
A new easy method for the synthesis of cyclic halogenoethers and halogenolactones (1984) (14)
Magel2 Modulates Bone Remodeling and Mass in Prader‐Willi Syndrome by Affecting Oleoyl Serine Levels and Activity (2018) (14)
Structure-activity relationships of pyrrole amidine antiviral antibiotics III: preparation of distamycin and congocidine derivatives based on 2,5-disubstituted pyrroles. (1980) (14)
Conversion of ruscogenin into 1α- and 1β hydroxycholesterol derivatives : Structure elucidation by computer assisted analysis of their lanthanide-induced nmr shifts (1981) (13)
Palmitoyl Serine: An Endogenous Neuroprotective Endocannabinoid-Like Entity After Traumatic Brain Injury (2015) (13)
A repeated test procedure to assess onset and duration of the cue properties of (-) delta 9-THC, (-) delta 8-THC-DMH and (+) delta 8-THC. (1981) (13)
Evaluation of repeated or acute treatment with cannabidiol (CBD), cannabidiolic acid (CBDA) or CBDA methyl ester (HU-580) on nausea and/or vomiting in rats and shrews (2020) (13)
[Increase of the heart arrhythmogenic resistance and decrease of the myocardial necrosis zone during activation of cannabinoid receptors]. (2002) (12)
Subjectively experienced cannabis effects in animals (1989) (12)
Comparative Evaluation of Combinatory Interaction between Endocannabinoid System Compounds and Poly-L-lysine against Streptococcus mutans Growth and Biofilm Formation (2020) (11)
Cannabinoids in Models of Chronic Inflammatory Conditions (2004) (11)
Benzoxocin and benzoxonin derivatives. Novel groups of terpenophenols with central nervous system activity. (1974) (10)
Synthesis of the Individual, Pharmacologically Distinct, Enantiomers of a Tetrahydrocannabinol Derivative. (1990) (10)
Identification of a C-Glucuronide of Dgr6-Tetrahydrocannabinol as a Mouse Liver Conjugate in vivo. (1978) (10)
Conversation with Raphael Mechoulam. (2007) (10)
Acute naloxone-precipitated morphine withdrawal elicits nausea-like somatic behaviors in rats in a manner suppressed by N-oleoylglycine (2019) (10)
Cannabinoid receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database (2019) (10)
Hippocampal Cannabinoid-1 Receptor Upregulation Upon Endothelin-B Receptor Deficiency: A Neuroprotective Substitution Effect? (2005) (10)
The structure of senegenic acid, a nortriterpene artifact from Polygala senega. (1965) (10)
Cannabinoid rearrangements: Synthesis of Δ5-tetrahydrocannabinol (1973) (10)
Notes - Basic Alcoholysis of the Trifluoromethyl Group in 1,1,1-Trifluoro-2,2-diarylethanes (1956) (10)
Synthesis and enzymatic formation of a C-glucuronide of delta6-tetrahydrocannabinol. (1977) (10)
Structural features affecting chiral discrimination of terpene derivatives on a carbamated amylose stationary phase. (1994) (9)
Endogenous cannabinoid ligands. (1996) (9)
Cannabidiol partially blocks the sleepiness in hypocretin-deficient rats. Preliminary data. (2019) (9)
Lipids in neural function: modulation of behavior by oral administration of endocannabinoids found in foods. (2001) (9)
Biology of endocannabinoids (2002) (9)
A developmental profile of estrogen and androgen radioimmunoactive substances in the flesh fly, Sarcophaga crassipalpis (1987) (9)
[Endocannabinoids and psychiatric disorders: the road ahead]. (2010) (9)
Are the endocannabinoid-like compounds N-acyl aminoacids neuroprotective after traumatic brain injury? (2016) (9)
Cannabinoid Chemistry: An Overview (2005) (9)
Activity of novel aminocannabinoids in baboons. (1984) (9)
Stereospecific cyclizations and isomerizations of cannabichromene and related cannabinoids. (1969) (9)
Chemical synthesis and biological occurrence of carboxylic acid metabolites of delta1(6)-tetrahydrocannabinol. (1979) (9)
Discriminative stimulus- and open-field effects of the enantiomers of 11-hydroxy-delta-8-tetrahydrocannabinol in pigeons and gerbils (1994) (9)
Adherence, Safety, and Effectiveness of Medical Cannabis and Epidemiological Characteristics of the Patient Population: A Prospective Study (2022) (9)
Cannabinoid Quinones—A Review and Novel Observations (2021) (9)
Therapeutic Potential of Cannabidiol, Cannabidiolic Acid, and Cannabidiolic Acid Methyl Ester as Treatments for Nausea and Vomiting. (2021) (8)
Effect of stereospecific cannabinoids on the immune system. (1991) (8)
Todd's achievement (1997) (8)
Cannabinoid 2 (CB2) receptor agonism reduces lithium chloride-induced vomiting in Suncus murinus and nausea-induced conditioned gaping in rats. (2016) (8)
CNS Cannabinoid Receptors (1994) (8)
The Role of Receptor Transactivation in the Cardioprotective Effects of Preconditioning and Postconditioning (2012) (8)
Delta 6-tetrahydrocannabinol-7-oic acid, a urinary delta 6-THC metabolite: isolation and synthesis. (1974) (8)
Human pharmacology of 1S and 1R enantiomers of delta-3-tetrahydrocannabinol (2004) (8)
Anticonvulsant and neurotoxic effects of tetrahydrocannabinol stereoisomers. (1987) (8)
Oleoyl glycine: interference with the aversive effects of acute naloxone-precipitated MWD, but not morphine reward, in male Sprague–Dawley rats (2019) (8)
Anandamide alters the membrane properties, halts the cell division and prevents drug efflux in multidrug resistant Staphylococcus aureus (2021) (8)
neuroprotective after brain injury (2001) (7)
Discriminative stimulus effects and receptor binding of enantiomeric pairs of cannabinoids in rats and pigeons; a comparison. (1993) (7)
International Association for Cannabinoid Medicines (2013) (7)
Base‐Catalyzed Conversion of an Equatorial into an Axial Methoxycarbonyl Group Due to a 1,5‐Long‐Range Substituent Effect (1980) (7)
CB 1 cannabinoid receptors are involved in neuroprotection via NF-jB inhibition (2005) (7)
New Advances in the Identification and Physiological Roles of the Components of the Endogenous Cannabinoid System (2003) (7)
Oleoyl alanine (HU595): a stable monomethylated oleoyl glycine interferes with acute naloxone precipitated morphine withdrawal in male rats (2020) (7)
Current Status of Therapeutic Opportunities Based on Cannabinoid Research. An Overview (1981) (7)
Syntheses of 1 -tetrahydrocannabinol and related cannabinoids. (1972) (7)
Formation of ortho-menthenes by acid-catalysed ring opening of pin-2-ene derivatives (1976) (6)
Derivatives of Dexanabinol. II. Salts of Amino Acid Esters Containing Tertiary and Quaternary Heterocyclic Nitrogen with Increased Water-Solubility (1996) (6)
The ovulation blocking effect of cannabinoids: Structure-activity relationships (1980) (6)
Cannabinoid receptors: pharmacology, second messenger systems and endogenous ligands. (1994) (6)
19-hydroxy-10-isotestosterone (1960) (6)
Binding and functional studies with the peripheral and neuronal cannabinoid receptors (1994) (6)
P.4.c.008 Cannabidiol presents an inverted U-shaped dose-response curve in the simulated public speaking test (2016) (6)
Early perceptual loss in depression (2007) (6)
Anandamide prevents the adhesion of filamentous Candida albicans to cervical epithelial cells (2020) (6)
The structure and synthesis of oleuropeic acid (1962) (6)
[Mass spectroscopy and its application to structural and stereochemical problems. 68. Mass spectroscopic studies of constituents of hashish]. (1965) (5)
Notes. The Dies-Alder Reaction of Steroidal 20-Methylene-Δ16-pregnene Derivatives with Maleic Anhydride (1959) (5)
A Delightful Trip Along the Pathway of Cannabinoid and Endocannabinoid Chemistry and Pharmacology. (2022) (5)
Nonpsychotropic synthetic cannabinoids as therapeutic agents. (2010) (5)
Looking ahead after 50 years of research on cannabinoids (2014) (5)
Sleep and neurochemical modulation by cannabidiolic acid methyl ester in rats (2019) (5)
Metabolism of delta 1(6)-tetrahydro--cannabinol, an active marihuana constituent. (1970) (5)
Protective effects of N-oleoylglycine in a mouse model of mild traumatic brain injury. (2020) (5)
Novel CBG Derivatives Can Reduce Inflammation, Pain and Obesity (2021) (5)
Involvement of central and peripheral cannabionoid receptors in the regulation of heart resistance to arrhythmogenic effects of epinephrine (2007) (5)
STEREOCHEMICAL REQUIREMENTS FOR CANNABINOID ACTIVITY (1981) (5)
Separation of the discriminative stimulus effects of stereoisomers of Δ2- and Δ3-tetrahydrocannabinols in pigeons (1988) (5)
Spectral effects in cyclobutane derivatives : The bathochromic-hypochromic shifts in compounds related to verbenone (1976) (4)
983 Cannabidiol Treatment Does Not Effect Active Crohn's Disease (2013) (4)
Intraperirhinal cortex administration of the synthetic cannabinoid, HU210, disrupts object recognition memory in rats (2015) (4)
Senegenic acid, a pentacyclic nor-triterpene acid (1964) (4)
Antiparasitic structure-activity relationships of congocidine derivatives. (1981) (4)
Spontaneous and Naloxone-Precipitated Withdrawal Behaviors From Chronic Opiates are Accompanied by Changes in N-Oleoylglycine and N-Oleoylalanine Levels in the Brain and Ameliorated by Treatment With These Mediators (2021) (4)
International Cannabis Research Society meeting summary, Keystone, CO (June 19-20, 1992). (1993) (4)
Relation between effects of cannabinoid derivatives on the twitch response of the isolated guinea-pig ileum and their psychotropic properties. (1978) (4)
Derivatives of Dexanabinol. I. Water-Soluble Salts of Glycinate Esters (2004) (4)
Sodium chromate oxidation of enol benzoates. Allylic oxidation versus a novel rearrangement (1977) (3)
BORON TRIFLUORIDE ETHERATE ON ALUMINA - A MODIFIED LEWIS ACID REAGENT. AN IMPROVED SYNTHESIS OF CANNABIDIOL (1985) (3)
Fenchone Derivatives as a Novel Class of CB2 Selective Ligands: Design, Synthesis, X-ray Structure and Therapeutic Potential (2022) (3)
Interaction of Cannabinoids with Model Membranes — NMR Studies (1978) (3)
Cannabidiol - An Innovative Strategy For Graft Versus Host Disease Prevention (2013) (3)
Effect of synthetic enantiomeric cannabinoids on platelet aggregation. (1992) (3)
N-Oleoylglycine and N-Oleoylalanine Do Not Modify Tolerance to Nociception, Hyperthermia, and Suppression of Activity Produced by Morphine (2021) (3)
STRUCTURE ELUCIDATION OF A CONDENSATION PRODUCT OF 4-AMINOPYRROLE DERIVATIVES AND DICYCLOHEXYLCARBODIIMIDE (1980) (3)
HU-671, a Novel Oleoyl Serine Derivative, Exhibits Enhanced Efficacy in Reversing Ovariectomy-Induced Osteoporosis and Bone Marrow Adiposity (2019) (3)
Peering through the smoke (2002) (3)
A Facile Method for Regiospecific Hydroxylation of Resorcinol Diethers (1983) (3)
Cannabinol: a rapidly formed metabolite of delta-1- and delta-6-tetrahydrocannabinol. (1975) (3)
Separation of the discriminative stimulus effects of stereoisomers of delta 2- and delta 3-tetrahydrocannabinols in pigeons. (1988) (3)
Targeting the Achilles’ Heel of Multidrug-Resistant Staphylococcus aureus by the Endocannabinoid Anandamide (2022) (3)
On the Fluorination of DDT with Hydrogen Fluoride and Mercuric Oxide (1957) (3)
1 The cannabinoid system : from the point of view of a chemist (2004) (3)
Total synthesis of cannabidiol and delta1-tetrahydrocannabinol metabolites. (1976) (3)
The Endocannabinoid System: A Look Back and Ahead. (2015) (3)
Identification of a C-Glucuronide of Δ6-Tetrahydrocannabinol as a Mouse Liver Conjugate in vivo (1978) (2)
The promise of advances in the field of endocannabinoids. (2004) (2)
Marijuana and Madness: The cannabinoid system: from the point of view of a chemist (2004) (2)
Comment on 'Health aspects of cannabis: revisited' (Hollister). (1998) (2)
Reactions of cannabinoid tosylhydrazones: stereochemical aspects (1984) (2)
Involvement of central and peripheral cannabionoid receptors in the regulation of heart resistance to arrhythmogenic effects of epinephrine (2000) (2)
Chapter 2 Alkaloids in Cannabis Sativa L. (1989) (2)
STRUCTURE-ACTIVITY RELATIONSHIPS OF PYRROLEAMIDINE ANTIVIRAL ANTIBIOTICS. 1. MODIFICATIONS OF THE ALKYLAMIDINE SIDE CHAIN (1980) (2)
O- and C-d-glucosyluronic acid derivatives of Δ1-tetrahydrocannabinol: Synthesis and differential behavior to β-glucuronidase☆☆☆ (1981) (2)
Effect of oleoyl glycine and oleoyl alanine on lithium chloride induced nausea in rats and vomiting in shrews (2021) (2)
A New Method for the Oxidation of Monoketones to 1,3-Diketones (1974) (2)
Oleoyl Serine, an Endogenous Regulator of Skeletal Mass (2010) (2)
The Cannabidiol Analog PECS-101 Prevents Chemotherapy-Induced Neuropathic Pain via PPARγ Receptors (2021) (2)
HU308 Mitigates Osteoarthritis by Stimulating Sox9‐Related Networks of Carbohydrate Metabolism (2022) (2)
Blowing away the smokescreen (2000) (2)
The Structure of Ceanothic Acid1 (1962) (2)
Pain reduction and lack of psychotropic effects with ajulemic acid: comment on the article by Sumariwalla et al - Reply (2004) (2)
BASE-CATALYZED DOUBLE-BOND ISOMERIZATIONS OF CANNABINOIDS: STRUCTURAL AND STEREOCHEMICAL ASPECTS (1985) (2)
A NEW EASY METHOD FOR THE SYNTHESIS OF CYCLIC HALO ETHERS AND HALO LACTONES (1985) (1)
Metabolism of 7-hydroxy- 1(6)-tetrahydrocannabinol in the rabbit. (1973) (1)
CANNABINOID REARRANGEMENTS, SYNTHESIS OF DELTA(5)-TETRAHYDROCANNABINOL (1973) (1)
Correction: Fluorinated Cannabidiol Derivatives: Enhancement of Activity in Mice Models Predictive of Anxiolytic, Antidepressant and Antipsychotic Effects (2016) (1)
The role of the cannabinoid system in feeding and appetite. (2005) (1)
PLANT AND BRAIN CANNABINOIDS: THE CHEMISTRY OF MAJOR NEW PLAYERS IN PHYSIOLOGY (2007) (1)
Cannabidiol – an Innovative Strategy for Graft Versus Host Disease Prevention – an Update of a Phase I/II Study (2014) (1)
HU-910, a CB2 receptor agonist, reverses behavioral changes in pharmacological rodent models for schizophrenia (2022) (1)
SYNTHESIS OF THE INDIVIDUAL, PHARNACOLOGICALLY DISTINCT, ENANTIONERS OF A TETRAHYDROCANNABINOL DERIVATIVE (1990) (1)
Cannabidiol attenuates alcohol-induced liver steatosis, metabolic dysregulation, inflammation and neutrophil-mediated injury (2017) (1)
Cannabinoid Receptor 2 Blockade Prevents Anti-Depressive-like Effect of Cannabidiol Acid Methyl Ester in Female WKY Rats (2023) (1)
Interaction of cannabinoid methanandamide with processes ofsensitization to both behavioral and immunologicalmethamphetamine effects in mice. (2004) (1)
Evaluation of Sex Differences in the Potential of Δ9-Tetrahydrocannabinol, Cannabidiol, Cannabidiolic Acid, and Oleoyl Alanine to Reduce Nausea-Induced Conditioned Gaping Reactions in Sprague-Dawley Rats. (2022) (1)
[A marihuana component for nausea and vomiting induced by chemo- and radiotherapy]. (1983) (1)
Abstracts of the 15th Annual Meeting of the Israel Society for Neuroscience Eilat, Israel, December 3–5, 2006 (2006) (1)
Behavioural effects of anandamide, a cannabinoid receptor agonist, in mice: 16.15 (1995) (1)
Maintained anxiolytic effects of cannabidiol after treatment discontinuation in healthcare workers during the COVID-19 pandemic (2022) (1)
N-Oleoyl Glycine and Its Derivatives Attenuate the Acquisition and Expression of Cocaine-Induced Behaviors. (2022) (1)
Synthesis of a potential urinary tetrahydrocannabinol metabolite. (1972) (1)
Isotope effect studies on the dehydrogenation of Δ1-tetrahydrocannabinol in the rat (1977) (1)
Cannabinoids: receptors, endogenous ligands and a newly synthesized antagonist. (1996) (1)
SYNTHESIS AND ENZYMIC FORMATION OF A C-GLUCURONIDE OF Δ6-TETRAHYDROCANNABINOL (1977) (1)
Anti-Tumorigenic Effect of a Novel Derivative of 2-Hydroxyoleic Acid and the Endocannabinoid Anandamide on Neuroblastoma Cells (2022) (1)
CANNABIDIOL AND PHENYTOIN: A STRUCTURAL COMPARISON (1980) (0)
Effect of prior foot shock stress and Δ9-tetrahydrocannabinol, cannabidiolic acid, and cannabidiol on anxiety-like responding in the light-dark emergence test in rats (2017) (0)
High MN1 expression is associated with poor prognosis in acute myeloid leukemia independent of allogeneic progenitor cell transplantation (2006) (0)
Albert Einstein Memorial Lectures (2012) (0)
Assessing the treatment of cannabidiolic acid methyl ester: a stable synthetic analogue of cannabidiolic acid on c-Fos and NeuN expression in the hypothalamus of rats (2021) (0)
Suppression of experimental autoimmune encephalomyelitis by Δ 8-tetrahydrocannabinol (1991) (0)
Peripubertal cannabidiol treatment prevents molecular and behavioral changes in neurodevelopmental model of schizophrenia (2018) (0)
Cannabidiol protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and cell death (2011) (0)
(3S, 4S) -7-hydroxy-delta (arrow high) 6 (arrow high) - tetrahydrocannabinol compounds, processes for their preparation and their use (1987) (0)
PHARMACOLOGY OF ENDOGENOUS AND EXOGENOUS CANNABINOID RECEPTOR AGONISTS (1998) (0)
Pesticides. I. the structure of dihydronicotyrine (2010) (0)
S.11.04 Endocannabinoids — intrepid defenders of the nervous system (2004) (0)
Antimicrobial potential of endocannabinoid and endocannabinoid-like compounds against methicillin-resistant Staphylococcus aureus (2018) (0)
Use of cannabinoids as anti-inflamatoprios agents. (1999) (0)
HU308-mediated cannabinoid signaling mitigates age and trauma-related osteoarthritis (2021) (0)
Using kannabidiol as anti-inflammatory agents (1999) (0)
Abstracts of the 16th Annual Meeting of The Israel Society for Neuroscience Eilat, Israel, November 25–27, 2007 (2008) (0)
Two New Unsaturated Fatty Acid Ethanolamides (I), (II) in Brain That Bind to the Cannabinoid Receptor. (1993) (0)
Isotope effect studies on the dehydrogenation of delta 1-tetrahydrocannabinol in the rat. (1977) (0)
Synthesis of [11C] HU-304*: A new radioligand for positron emission tomographic studies of cannabinoid receptors (1999) (0)
Cannabinoids metabolic patterns vs biological activity (1977) (0)
(3S, 4S) -7-hydroxy-delta · 6 · - tetrahydrocannabinol compounds, process for their preparation and medicaments containing these compounds (1987) (0)
Synthetic endogenous cannabinoid analog and their uses (1999) (0)
Oleoyl glycine: interference with the aversive effects of acute naloxone-precipitated MWD, but not morphine reward, in male Sprague–Dawley rats (2019) (0)
Effects of Preconditioning on Coronary Perfusion in Cardiac Ischemia and Reperfusion (2013) (0)
(6a s, 10a s)-1-hydroxy- 8-thc derivatives (1987) (0)
3- (6-alkoxy-4-alkyl-2-hydroxyphenyl) cyclohexanol derivatives and these drug compounds containing (1986) (0)
Acknowledgment to reviewers (1979) (0)
Synthetic analogs of endogenous cannabinoids and their uses. (1999) (0)
RESEARCH PAPER THEMED ISSUE (CANNABINOIDS IN BIOLOGY AND MEDICINE) (2011) (0)
Analgetic and antiemetic 3-(substituted-phenyl)cyclohexanol derivatives (1986) (0)
STRUCTURE-ACTIVITY RELATIONSHIPS OF PYRROLE AMIDINE ANTIVIRAL ANTIBIOTICS. III: PREPARATION OF DISTAMYCIN AND CONGOCIDINE DERIVATIVES BASED ON 2,5-DISUBSTITUTED PYRROLES (1981) (0)
Contents, Vol. 39, 1989 (1982) (0)
Effects of pharmacological modulation of the endocannabinoidsystem in a neurodevelopmental animal model of schizophrenia (2016) (0)
P.2.25 Cannabidiol (CBD) ameliorates cognitive impairments associated with a model of chronic liver disease in mice (2008) (0)
Real life Experience of Medical Cannabis Treatment in Autism: Analysis of Safety and Efficacy (2019) (0)
Palmitoyl Serine: An Endogenous Neuroprotective Endocannabinoid-Like Entity After Traumatic Brain Injury (2015) (0)
Corrigendum: Cannabinoids and Capsaicin Improve Liver Function Following Thioacetamide-Induced Acute Injury in Mice (2009) (0)
PL.01 The endocannabinoids: functional roles and therapeutic opportunities (2007) (0)
Books Received (1977) (0)
CANNABIDIOLIC ACID ESTERS COMPOSITIONS AND USES THEREOF (2018) (0)
United States Patent ( 19 ) Mechoulam (2017) (0)
BASE-CATALYZED CONVERSION OF AN EQUATORIAL INTO AN AXIAL METHOXYCARBONYL GROUP BASED ON A SUBSTITUENT-1,5-DISTANCE EFFECT (1980) (0)
(3S, 4S) -delta-6-tetrahydrocannabinol-7-acids and their derivatives, processes for their preparation and pharmaceutical compositions containing them (1992) (0)
endoCANNABINOIDS (2013) (0)
Skeletal anabolic activity of cannabinoid receptor agonists (2009) (0)
Dexanabinol derivatives and compositions their use as neuroprotective pharmaceutical (1995) (0)
Cannabinoids found naturally in the brain may suppress vomiting and nausea (2013) (0)
P.2.a.029 Anti-depressant-like effects of cannabidiol and cannabidiolic acid in genetic rat models of depression (2017) (0)
endotoxin-free , synthetic TLR 4 agonists , may allow exploitation of both IL-12 and regulatory DC to suppress GVHD . 440 Trametinib Selectively Inhibits Alloreactivity While Sparing Virus-Speci fi c T Cells (2014) (0)
201 – Cannabidiol Protects againstChronic Plus Binge Alcohol Induced Liver Injury by Modulating Neutrophil Infiltration, E Selectin, Inflammation and Oxidative/Nitrative Stress (2014) (0)
GVH/GVLCannabidiol for the Prevention of Graft-Versus-Host-Disease after Allogeneic Stem Cell Transplantation: Results of a Phase I/II Study (2015) (0)
Peripubertal treatment with cannabidiol reverses behavioral alterations in ∆9-THC animal model of schizophrenia (2018) (0)
P.3.c.010 Early pharmacological modulation of the endogenous cannabinoid signaling counteracts the phenotype in a rodent developmental disruption model of schizophrenia at adulthood (2016) (0)
Specific anonisten for peripheral cannabinoid receptors (2000) (0)
P.3.e.011 Endocannabinoid system genes regulation in schizophrenia (2016) (0)
Effects of Preconditioning on Coronary Perfusion in Cardiac Ischemia and Reperfusion (2013) (0)
The Role of Receptor Transactivation in the Cardioprotective Effects of Preconditioning and Postconditioning (2013) (0)
P.6.d.004 Brain imaging study on the effects of delta-9 THC on orientation and motor coordination in regular users of marijuana (2006) (0)
Cannabidiol, a non-intoxicating component of cannabis, suppresses nausea and vomiting in rats and shrews (2013) (0)
ACTIVITY OF NOVEL AMINOCANNABINOIDS IN BABOONS (1985) (0)
Early modulation of the endocannabinoid tone prevents the onset of a schizophrenia-likephenotype (2017) (0)
Compounds of tetrahydrocannabinol type and pharmaceutical compositions containing them (1977) (0)
A Fenchone Derivative Effectively Abrogates Joint Damage Following Post-Traumatic Osteoarthritis in Lewis Rats (2022) (0)
P.3.a.007 Disturbed DISC1 pathway interacts with adolescent cannabis exposure to produce impaired recognition memory restored by BDNF over-expression: a host-environment mouse model of severe mental illness (2016) (0)
P.2.020 Early modulation of the endocannabinoid tone prevents molecular and behavioral alterations in MAM model of schizophrenia (2017) (0)
STRUCTURE-ACTIVITY RELATIONSHIPS OF PYRROLE AMIDINE ANTIVIRAL ANTIBIOTICS. 2. REPARATION OF MONO- AND TRIPYRROLE DERIVATIVES OF CONGOCIDINE (1981) (0)
Effect of the synthetic cannabinoid HU-210 on quorum sensing and on the production of quorum sensing-mediated virulence factors by Vibrio harveyi (2015) (0)
Cannabinoids and Ischemia–Induced Retinal Neovascularization (2005) (0)
2-arachidonylglycerol (2-AG) - inhibitor factor alpha tumor necrosis and cerebral neuroprotective in closed head injury. (2001) (0)
High-Voltage-Activated Calcium Currents in Cannabinoids Modulate the P-Type (2015) (0)
On the Mechanisms of DDT-Resistance. (1956) (0)
Tumor necrosis factor alpha (TNF-alpha) inflammatory drugs (1996) (0)
A synthetic analogue of cannabidiolic acid that acts like a positive allosteric modulator at 5-HT1A receptors (2019) (0)
Use of cannabidiol in the treatment of nausea and vomiting induced by chemotherapy (2003) (0)
The synthesis of 19-hydroxy-10-alpha-testosterone. (1964) (0)
CANNABIELSOIC ACIDS, ISOLATION AND SYNTHESIS BY A NOVEL OXIDATIVE CYCLIZATION (1974) (0)
(3s, 4s) hydroxy-7 delta-6-tetrahydrocannabinol derivatives and derivatives (1987) (0)
Look Back in Ananda—40 Years of Research on Cannabinoids (2005) (0)
LIGANDS OFTHE CANNABINOID RECEPTORS (1998) (0)
Acute naloxone-precipitated morphine withdrawal elicits nausea-like somatic behaviors in rats in a manner suppressed by N-oleoylglycine (2019) (0)
FORMATION OF ORTHO-MENTHENES BY ACID-CATALYZED RING OPENING OF PIN-2-ENE DERIVATIVES (1976) (0)
Acids (3R, 4R) -delta6-tetrahydrocannabinol-7-oic. (1993) (0)
Endocannabinioid system : a look back and ahead, The (2017) (0)
Identification of 5-alpha-androstane-3-alpha, 17-beta-diol as a principal metabolite of pregnenolone in rat ovary at onset of puberty. (1970) (0)
Synthesi of delta-1, and delta-1 (6) tetrahydrocannabinol metabolites. (1970) (0)
Novel role of ‘entourage’ monoacylglycerols in function of human cerebral microvascular endothelial cells (2005) (0)
Inflammatory and Cell Death Signaling Pathways in Diabetic Cardiomyopathy Cannabidiol Attenuates Cardiac Dysfunction, Oxidative Stress, Fibrosis, and (2010) (0)
The Cannabidiol Analog PECS-101 Prevents Chemotherapy-Induced Neuropathic Pain via PPARγ Receptors (2021) (0)
CBD (2022) (0)
Mandarin Translations (2011) (0)
analgesic compositions based on (alkoxy-alkyl-hydroxy-phenyl) cyclohexanol (1986) (0)
Suppression of deafferentation-induced chronic pain behavior in the rat by HU211 — An anti-nociceptive synthetic cannabinoid with nmda receptor-blocking properties (1990) (0)
O-and C-D-glucosyluronic acid derivatives of delta 1-tetrahydrocannabinol: synthesis and differential behavior to beta-glucuronidase. (1981) (0)
Critical role of the endocannabinoid system in bone homeostasis (2007) (0)
A Role for Cerebrovascular Endothelium in Ischemia and Reperfusion (2004) (0)
CONVERSION OF RUSCOGENIN INTO 1α- AND 1β-HYDROXYCHOLESTEROL DERIVATIVES. STRUCTURE ELUCIDATION BY COMPUTER ASSISTED ANALYSIS OF THEIR LANTHANIDE-INDUCED NMR SHIFTS (1981) (0)
460 Assessment of the anti-inflammatory effects of fluorinated semi-synthetic phytocannabinoids in human in vitro inflammatory keratinocyte model systems (2017) (0)
Novel Endothelial-Mediated Responses Associated with Microcirculation and BBB Function (2001) (0)
Halogenation of Phenols and Phenyl Ethers with Potassium Halides in the Presence of 18-Crown-6 on Oxidation with m-Chloroperbenzoic Acid. (1987) (0)
[Medicines developed from hashish]. (1976) (0)
5. The Development of Chemical Testing (2017) (0)
ADENYLATE CYCLASE INHIBITION BY THE PERIPHERAL CANNABINOID RECEPTOR (1995) (0)
Benzoxocin and benzoxonin derivatives, Novel groups of terpenophenols with central nervous system activity. A correction. (1974) (0)
Marijuana and Madness: Other cannabinoids (2011) (0)
Erratum to: The effect of cannabidiol and URB597 on conditioned gaping (a model of nausea) elicited by a lithium-paired context in the rat (2011) (0)
Novel Synthesis of C-Methylated Phytocannabinoids Bearing Anti-inflammatory Properties (2023) (0)

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