Raquel Seruca
#113,511
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Oncobiologist
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Raquel Serucamedical Degrees
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#3537
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#4010
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Oncology
#249
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#257
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Raquel Seruca's Degrees
- PhD Biomedical Sciences University of Lisbon
- Masters Biomedical Sciences University of Lisbon
- Bachelors Biomedical Sciences University of Lisbon
Why Is Raquel Seruca Influential?
(Suggest an Edit or Addition)According to Wikipedia, Racquel Seruca was a Portuguese oncobiologist known for her work on stomach cancer. Life Seruca was born and raised in Porto. She graduated in medicine at the University of Porto before obtaining a PhD in the molecular genetics of stomach cancer in 1995. She was supervised by Professor . She was then a fellow at the University of Groningen in the Human Genetics department.
Raquel Seruca's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- BRAF mutations and RET/PTC rearrangements are alternative events in the etiopathogenesis of PTC (2003) (681)
- Helicobacter pylori and interleukin 1 genotyping: an opportunity to identify high-risk individuals for gastric carcinoma. (2002) (646)
- Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome. (1993) (636)
- Evaluation of tumor microsatellite instability using five quasimonomorphic mononucleotide repeats and pentaplex PCR. (2002) (563)
- A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma. (2003) (493)
- Familial gastric cancer: overview and guidelines for management* (1999) (483)
- Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline CDH1 mutation carriers (2015) (461)
- Interleukin 1B and interleukin 1RN polymorphisms are associated with increased risk of gastric carcinoma. (2001) (450)
- Germline E-cadherin mutations in hereditary diffuse gastric cancer: assessment of 42 new families and review of genetic screening criteria (2004) (374)
- BRAF screening as a low-cost effective strategy for simplifying HNPCC genetic testing (2004) (349)
- The prevalence of PIK3CA mutations in gastric and colon cancer. (2005) (340)
- Identification of germ-line E-cadherin mutations in gastric cancer families of European origin. (1998) (333)
- Early gastric cancer in young, asymptomatic carriers of germ-line E-cadherin mutations. (2001) (320)
- E-cadherin gene (CDH1) promoter methylation as the second hit in sporadic diffuse gastric carcinoma (2001) (282)
- Familial gastric cancer: genetic susceptibility, pathology, and implications for management. (2015) (271)
- Model of the early development of diffuse gastric cancer in E‐cadherin mutation carriers and its implications for patient screening (2004) (258)
- Determination of the replication error phenotype in human tumors without the requirement for matching normal DNA by analysis of mononucleotide repeat microsatellites (1998) (251)
- Microsatellite instability at multiple loci in gastric carcinoma: clinicopathologic implications and prognosis. (1996) (246)
- KRAS mutation testing for predicting response to anti-EGFR therapy for colorectal carcinoma: proposal for an European quality assurance program (2008) (234)
- Epithelial E- and P-cadherins: role and clinical significance in cancer. (2012) (216)
- Germline CDH1 deletions in hereditary diffuse gastric cancer families (2009) (202)
- Identification of CDH1 germline missense mutations associated with functional inactivation of the E-cadherin protein in young gastric cancer probands. (2003) (195)
- KRAS and BRAF oncogenic mutations in MSS colorectal carcinoma progression (2007) (179)
- Characterization of a Recurrent Germ Line Mutation of the E-Cadherin Gene: Implications for Genetic Testing and Clinical Management (2005) (178)
- BRAF-V600E is not involved in the colorectal tumorigenesis of HNPCC in patients with functional MLH1 and MSH2 genes (2005) (174)
- Cleft lip/palate and CDH1/E-cadherin mutations in families with hereditary diffuse gastric cancer (2005) (173)
- Screening E‐cadherin in gastric cancer families reveals germline mutations only in hereditary diffuse gastric cancer kindred (2002) (167)
- Genetics, Pathology, and Clinics of Familial Gastric Cancer (2006) (163)
- Biomarkers for gastric cancer: prognostic, predictive or targets of therapy? (2014) (161)
- Somatic mutations and deletions of the E-cadherin gene predict poor survival of patients with gastric cancer. (2013) (161)
- Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells. (2009) (157)
- Quantification of epigenetic and genetic 2nd hits in CDH1 during hereditary diffuse gastric cancer syndrome progression. (2009) (157)
- Distinct patterns of KRAS mutations in colorectal carcinomas according to germline mismatch repair defects and hMLH1 methylation status. (2004) (154)
- The clinicopathological features of gastric carcinomas with microsatellite instability may be mediated by mutations of different "target genes": a study of the TGFbeta RII, IGFII R, and BAX genes. (1998) (153)
- BRAF mutations characterize colon but not gastric cancer with mismatch repair deficiency (2003) (153)
- Modulation of E-cadherin function and dysfunction by N-glycosylation (2011) (147)
- Ionizing radiation modulates human macrophages towards a pro-inflammatory phenotype preserving their pro-invasive and pro-angiogenic capacities (2016) (145)
- Hereditary diffuse gastric cancer: updated clinical practice guidelines. (2020) (145)
- BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: Primary or secondary genetic events in colorectal carcinogenesis? (2008) (141)
- Helicobacter pylori Infection Induces Genetic Instability of Nuclear and Mitochondrial DNA in Gastric Cells (2009) (140)
- KRAS mutation testing for predicting response to anti-EGFR therapy for colorectal carcinoma: proposal for an European quality assurance program (2008) (140)
- Sporadic gastric carcinomas with microsatellite instability display a particular clinicopathologic profile (1995) (134)
- Highlights of the EORTC St. Gallen International Expert Consensus on the primary therapy of gastric, gastroesophageal and oesophageal cancer - differential treatment strategies for subtypes of early gastroesophageal cancer. (2012) (133)
- Lack of microRNA‐101 causes E‐cadherin functional deregulation through EZH2 up‐regulation in intestinal gastric cancer (2012) (121)
- Extracellular cleavage and shedding of P-cadherin: a mechanism underlying the invasive behaviour of breast cancer cells (2010) (115)
- Microsatellite instability, mitochondrial DNA large deletions, and mitochondrial DNA mutations in gastric carcinoma (2001) (113)
- Germline mutations of the E-cadherin(CDH1) and TP53 genes, rather than of RUNX3 and HPP1, contribute to genetic predisposition in German gastric cancer patients (2004) (110)
- The role of N-acetylglucosaminyltransferase III and V in the post-transcriptional modifications of E-cadherin. (2009) (110)
- Activated BRAF targets proximal colon tumors with mismatch repair deficiency and MLH1 inactivation (2004) (109)
- Helicobacter pylori Induces Gastric Epithelial Cell Invasion in a c-Met and Type IV Secretion System-dependent Manner* (2006) (106)
- Chromosomal changes in human primary testicular nonseminomatous germ cell tumors. (1989) (104)
- E-Cadherin (CDH1) and p53 rather than SMAD4 and Caspase-10 germline mutations contribute to genetic predisposition in Portuguese gastric cancer patients. (2004) (104)
- Candidate driver genes in microsatellite‐unstable colorectal cancer (2012) (103)
- Molecular pathology of familial gastric cancer, with an emphasis on hereditary diffuse gastric cancer (2007) (100)
- CagA associates with c-Met, E-cadherin, and p120-catenin in a multiproteic complex that suppresses Helicobacter pylori-induced cell-invasive phenotype. (2009) (100)
- E-cadherin and adherens-junctions stability in gastric carcinoma: functional implications of glycosyltransferases involving N-glycan branching biosynthesis, N-acetylglucosaminyltransferases III and V. (2013) (99)
- Loss and Recovery of Mgat3 and GnT-III Mediated E-cadherin N-glycosylation Is a Mechanism Involved in Epithelial-Mesenchymal-Epithelial Transitions (2012) (99)
- Preventing E-cadherin aberrant N-glycosylation at Asn-554 improves its critical function in gastric cancer (2016) (98)
- Oncogenic mutations in gastric cancer with microsatellite instability. (2011) (98)
- The intracellular E-cadherin germline mutation V832 M lacks the ability to mediate cell–cell adhesion and to suppress invasion (2003) (97)
- Allele-specific CDH1 downregulation and hereditary diffuse gastric cancer. (2010) (97)
- Loss of Heterozygosity and Promoter Methylation, but not Mutation, May Underlie Loss of TFF1 in Gastric Carcinoma (2002) (96)
- Helicobacter pylori infection generates genetic instability in gastric cells. (2010) (93)
- Cytogenetic analysis of ten human seminomas. (1989) (93)
- E‐cadherin dysfunction in gastric cancer ‐ Cellular consequences, clinical applications and open questions (2012) (93)
- EGFR regulates RhoA-GTP dependent cell motility in E-cadherin mutant cells. (2007) (93)
- Intragenic deletion of CDH1 as the inactivating mechanism of the wild-type allele in an HDGC tumour (2004) (92)
- MUC1 gene polymorphism and gastric cancer–an epidemiological study (2004) (91)
- Gastric cancer: adding glycosylation to the equation. (2013) (90)
- Macrophages stimulate gastric and colorectal cancer invasion through EGFR Y1086, c-Src, Erk1/2 and Akt phosphorylation and smallGTPase activity (2014) (90)
- E-cadherin germline missense mutations and cell phenotype: evidence for the independence of cell invasion on the motile capabilities of the cells. (2003) (90)
- Identification of seven novel germline mutations in the human E‐cadherin (CDH1) Gene (2007) (89)
- Chromosomal analysis and the classification of soft tissue sarcomas. (1989) (89)
- The NMD mRNA surveillance pathway downregulates aberrant E-cadherin transcripts in gastric cancer cells and in CDH1 mutation carriers (2008) (83)
- Docosahexaenoic Acid Inhibits Helicobacter pylori Growth In Vitro and Mice Gastric Mucosa Colonization (2012) (82)
- The importance of E-cadherin binding partners to evaluate the pathogenicity of E-cadherin missense mutations associated to HDGC (2012) (82)
- P‐cadherin functional role is dependent on E‐cadherin cellular context: a proof of concept using the breast cancer model (2013) (79)
- P-cadherin role in normal breast development and cancer. (2011) (79)
- De novo expression of CD44 variants in sporadic and hereditary gastric cancer (2010) (79)
- E-cadherin genetic screening and clinico-pathologic characteristics of early onset gastric cancer. (2011) (77)
- Specific clinical and biological features characterize inflammatory bowel disease associated colorectal cancers showing microsatellite instability. (2007) (77)
- Abnormalities of the E‐cadherin/catenin adhesion complex in classical papillary thyroid carcinoma and in its diffuse sclerosing variant (2001) (75)
- Target gene mutation profile differs between gastrointestinal and endometrial tumors with mismatch repair deficiency. (2002) (73)
- A model to infer the pathogenic significance of CDH1 germline missense variants (2006) (73)
- MSI phenotype and MMR alterations in familial and sporadic gastric cancer (2011) (72)
- Microbial-based therapy of cancer: Current progress and future prospects (2010) (71)
- P‐Cadherin Is Coexpressed with CD44 and CD49f and Mediates Stem Cell Properties in Basal‐like Breast Cancer (2012) (70)
- E-Cadherin Destabilization Accounts for the Pathogenicity of Missense Mutations in Hereditary Diffuse Gastric Cancer (2012) (69)
- B-Raf(V600E) cooperates with alternative spliced Rac1b to sustain colorectal cancer cell survival. (2008) (69)
- Causes and consequences of microsatellite instability in gastric carcinogenesis. (2014) (68)
- E-cadherin mutations and cell motility: a genotype-phenotype correlation. (2009) (68)
- The novel colorectal cancer biomarkers CDO1, ZSCAN18 and ZNF331 are frequently methylated across gastrointestinal cancers (2014) (65)
- Endoplasmic reticulum quality control: a new mechanism of E-cadherin regulation and its implication in cancer. (2008) (64)
- Chromosomal changes in mature residual teratomas following polychemotherapy. (1989) (64)
- Colorectal cancer and RASSF family—A special emphasis on RASSF1A (2013) (63)
- Epidermal growth factor receptor structural alterations in gastric cancer (2008) (63)
- Clinical spectrum and pleiotropic nature of CDH1 germline mutations (2019) (63)
- NOD2/CARD15 and TNFA, But Not ILLB and ILLRN, are Associated With Crohn's Disease (2005) (61)
- BRAF provides proliferation and survival signals in MSI colorectal carcinoma cells displaying BRAFV600E but not KRAS mutations (2008) (61)
- Concomitant RASSF1A hypermethylation and KRAS/BRAF mutations occur preferentially in MSI sporadic colorectal cancer (2005) (60)
- P53 mutations in gastric carcinomas. (1992) (58)
- Methylation tolerance due to an O6-methylguanine DNA methyltransferase (MGMT) field defect in the colonic mucosa: an initiating step in the development of mismatch repair-deficient colorectal cancers (2010) (58)
- Loss of functional E-cadherin renders cells more resistant to the apoptotic agent taxol in vitro. (2005) (58)
- The interferon gamma receptor 1 (IFNGR1) −56C/T gene polymorphism is associated with increased risk of early gastric carcinoma (2008) (56)
- i(12p)-negative testicular germ cell tumors. A different group? (1988) (53)
- E-cadherin alterations in hereditary disorders with emphasis on hereditary diffuse gastric cancer. (2013) (53)
- Increasing levels of MYC and MET co-amplification during tumor progression of a case of gastric cancer. (1995) (52)
- E-cadherin germline mutation carriers: clinical management and genetic implications (2014) (51)
- c-erbB-2 expression in primary gastric carcinomas and their metastases. (1992) (51)
- Hereditary lobular breast cancer with an emphasis on E-cadherin genetic defect (2018) (51)
- Identification of two distinct regions of deletion at 6q in gastric carcinoma (1995) (51)
- Identification of germline mutations in the cancer predisposing gene CDH1 in patients with orofacial clefts. (2013) (50)
- MSI-L Gastric Carcinomas Share the hMLH1 Methylation Status of MSI-H Carcinomas but Not Their Clinicopathological Profile (2000) (50)
- Concurrent hypermethylation of gene promoters is associated with a MSI-H phenotype and diploidy in gastric carcinomas. (2003) (50)
- Cytogenetic findings in eleven gastric carcinomas. (1993) (50)
- The interleukin-8-251*T/*A polymorphism is not associated with risk for gastric carcinoma development in a Portuguese population (2008) (50)
- CLMP is required for intestinal development, and loss-of-function mutations cause congenital short-bowel syndrome. (2012) (50)
- Promoter methylation of TGFβ receptor I and mutation of TGFβ receptor II are frequent events in MSI sporadic gastric carcinomas (2003) (49)
- Molecular cloning of the synovial sarcoma-specific translocation (X;18)(p11.2;q11.2) breakpoint. (1994) (48)
- The Extracellular Matrix: An Accomplice in Gastric Cancer Development and Progression (2020) (47)
- CPEB1, a novel gene silenced in gastric cancer: a Drosophila approach (2011) (44)
- Evidence of tumor microsatellite instability in gastric cancer with familial aggregation (2009) (44)
- E-cadherin impairment increases cell survival through Notch-dependent upregulation of Bcl-2. (2012) (44)
- High EPHB2 mutation rate in gastric but not endometrial tumors with microsatellite instability (2007) (43)
- Hyperplastic polyposis and diffuse carcinoma of the stomach. A study of a family (1993) (43)
- Predicting the Functional Impact of CDH1 Missense Mutations in Hereditary Diffuse Gastric Cancer (2017) (42)
- Characterization of the P373L E-cadherin germline missense mutation and implication for clinical management. (2007) (41)
- Hereditary gastric cancer. (2009) (41)
- Two pairs of proven monozygotic twins discordant for familial amyloid neuropathy (FAP) TTR Met 30 (1999) (40)
- E-cadherin missense mutations, associated with hereditary diffuse gastric cancer (HDGC) syndrome, display distinct invasive behaviors and genetic interactions with the Wnt and Notch pathways in Drosophila epithelia. (2006) (40)
- Blue intensity matters for cell cycle profiling in fluorescence DAPI-stained images (2017) (40)
- Genetic Screening for Familial Gastric Cancer (2004) (40)
- Rare Variants in the Epithelial Cadherin Gene Underlying the Genetic Etiology of Nonsyndromic Cleft Lip with or without Cleft Palate (2015) (39)
- Role of pathology in the identification of hereditary diffuse gastric cancer: report of a Portuguese family (2005) (38)
- Tumor Necrosis Factor Alpha Extended Haplotypes and Risk of Gastric Carcinoma (2008) (38)
- Role of site-specific promoter hypomethylation in aberrant MUC2 mucin expression in mucinous gastric carcinomas. (2003) (38)
- Benign and malignant thyroid lesions show instability at microsatellite loci. (1997) (38)
- Hereditary diffuse gastric cancer and E-cadherin: description of the first germline mutation in an Italian family. (2007) (38)
- The Bacterial Protein Azurin Impairs Invasion and FAK/Src Signaling in P-Cadherin-Overexpressing Breast Cancer Cell Models (2013) (38)
- Microsatellite instability in hyperplastic and adenomatous polyps of the stomach (1999) (38)
- Helicobacter pylori infection affects mitochondrial function and DNA repair, thus, mediating genetic instability in gastric cells (2013) (37)
- E‐cadherin deregulation in breast cancer (2020) (37)
- Hereditary diffuse gastric cancer - pathophysiology and clinical management. (2014) (36)
- Mutant BRAF induces DNA strand breaks, activates DNA damage response pathway, and up-regulates glucose transporter-1 in nontransformed epithelial cells. (2012) (36)
- C/EBPbeta is over‐expressed in gastric carcinogenesis and is associated with COX‐2 expression (2006) (36)
- H-RAS 81 polymorphism is significantly associated with aneuploidy in follicular tumors of the thyroid (2006) (36)
- Adherens junctions as targets of microorganisms: A focus on Helicobacter pylori (2013) (35)
- Establishment and characterization of two cell lines derived from human diffuse gastric carcinomas xenografted in nude mice (1996) (35)
- Patterns of β-Catenin Expression in Gastric Carcinoma: Clinicopathological Relevance and Mutation Analysis (2003) (35)
- CD44 alternative splicing in gastric cancer cells is regulated by culture dimensionality and matrix stiffness. (2016) (33)
- Insulin/IGF-I Signaling Pathways Enhances Tumor Cell Invasion through Bisecting GlcNAc N-glycans Modulation. An Interplay with E-Cadherin (2013) (33)
- Molecular targets and biological modifiers in gastric cancer. (2008) (33)
- Colorectal cancer-related mutant KRAS alleles function as positive regulators of autophagy (2015) (33)
- Detection of numerical alterations for chromosomes 7 and 12 in benign thyroid lesions by in situ hybridization. Histological implications. (1995) (33)
- Familial gastric polyposis revisited. Autosomal dominant inheritance confirmed. (1991) (32)
- Tumour selection advantage of non-dominant negative P53 mutations in homozygotic MDM2-SNP309 colorectal cancer cells (2006) (32)
- Clinical utility gene card for: Hereditary diffuse gastric cancer (HDGC) (2013) (32)
- O-mannosylation and N-glycosylation: two coordinated mechanisms regulating the tumour suppressor functions of E-cadherin in cancer (2016) (32)
- P53 in breast carcinomas: association between presence of mutation and immunohistochemical expression using a semiquantitative approach. (1998) (30)
- β‐Catenin (CTNNB1) gene amplification: A new mechanism of protein overexpression in cancer (2005) (30)
- Intricate Macrophage-Colorectal Cancer Cell Communication in Response to Radiation (2016) (30)
- Proliferation and survival molecules implicated in the inhibition of BRAF pathway in thyroid cancer cells harbouring different genetic mutations (2009) (30)
- Microsatellite instability in medullary breast carcinomas (1999) (30)
- Somatic mutations in mismatch repair genes in sporadic gastric carcinomas are not a cause but a consequence of the mutator phenotype. (2008) (29)
- Mixed lineage kinase 3 gene mutations in mismatch repair deficient gastrointestinal tumours (2009) (29)
- CLMP Is Essential for Intestinal Development, but Does Not Play a Key Role in Cellular Processes Involved in Intestinal Epithelial Development (2013) (29)
- ADP-Ribosylation Factor 6 Mediates E-Cadherin Recovery by Chemical Chaperones (2011) (28)
- Promoter methylation of TGFbeta receptor I and mutation of TGFbeta receptor II are frequent events in MSI sporadic gastric carcinomas. (2003) (27)
- Karyotyping and DNA flow cytometry of an orchidoblastoma. (1988) (27)
- Frequent Ki-ras mutations in gastric tumors of the MSI phenotype. (2003) (27)
- Target gene mutational pattern in Lynch syndrome colorectal carcinomas according to tumour location and germline mutation (2015) (26)
- Therapeutic targets associated to E-cadherin dysfunction in gastric cancer (2013) (26)
- E-cadherin-defective gastric cancer cells depend on Laminin to survive and invade. (2015) (26)
- C/EBPα expression is associated with homeostasis of the gastric epithelium and with gastric carcinogenesis (2010) (26)
- Matrix metalloproteases as maestros for the dual role of LPS- and IL-10-stimulated macrophages in cancer cell behaviour (2015) (25)
- Quantification of mutant E-cadherin using bioimaging analysis of in situ fluorescence microscopy. A new approach to CDH1 missense variants (2014) (25)
- Targeting the Tumor Microenvironment: An Unexplored Strategy for Mutant KRAS Tumors (2019) (25)
- High Incidence of Familial Gastric Cancer in Tuscany, a Region in Italy (2008) (24)
- Gastric cancer carcinogenesis and tumor progression. (2012) (24)
- Sequence diversity at the proximal 14q32.1 SERPIN subcluster: evidence for natural selection favoring the pseudogenization of SERPINA2. (2006) (24)
- Comments on: mutations in mitochondrial control region DNA in gastric tumours of Japanese patients, Tamura, et al. Eur J Cancer 1999, 35, 316-319. (1999) (24)
- Tetra‐and pentanucleotide short tandem repeat instability in gastric cancer (1997) (24)
- ICI 182,780 induces P-cadherin overexpression in breast cancer cells through chromatin remodelling at the promoter level: a role for C/EBPbeta in CDH3 gene activation. (2010) (24)
- Cytogenetics of a case of osteosarcoma. (1988) (23)
- Estrogens, MSI and Lynch syndrome-associated tumors. (2009) (23)
- A malignant mixed gonadal stromal tumor of the testis with heterologous components and i(12p) in one of its metastases. (1989) (23)
- High-throughput molecular profiling of a P-cadherin overexpressing breast cancer model reveals new targets for the anti-cancer bacterial protein azurin. (2014) (23)
- Hyperplastic polyposis and diffuse carcinoma of the stomach. A study of a family. (1993) (23)
- Mononucleotide precedes dinucleotide repeat instability during colorectal tumour development in Lynch syndrome patients (2009) (23)
- Hereditary Gastric and Breast Cancer Syndromes Related to CDH1 Germline Mutation: A Multidisciplinary Clinical Review (2020) (22)
- Crosstalk between Helicobacter pylori and Gastric Epithelial Cells Is Impaired by Docosahexaenoic Acid (2013) (22)
- Gastric Cardia Carcinoma is Associated with the Promoter -77T>C Gene Polymorphism of X-Ray Cross-Complementing Group 1 (XRCC1) (2009) (21)
- The mechanisms underlying MMR deficiency in immunodeficiency‐related non‐Hodgkin lymphomas are different from those in other sporadic microsatellite instable neoplasms (2009) (20)
- DNAJB4 molecular chaperone distinguishes WT from mutant E-cadherin, determining their fate in vitro and in vivo. (2014) (20)
- Analysis of microsatellite instability in medulloblastoma. (2009) (20)
- CCAAT/Enhancer Binding Protein β (C/EBPβ) Isoforms as Transcriptional Regulators of the Pro-Invasive CDH3/P-Cadherin Gene in Human Breast Cancer Cells (2013) (19)
- Cytogenetic study of a sclerosing stromal tumor of the ovary. (1990) (19)
- Unmasking the role of KRAS and BRAF pathways in MSI colorectal tumors (2009) (19)
- Detection of N-myc Amplification in Neuroblastomas Using Southern Blotting on Fine Needle Aspirates (2001) (19)
- In vitro demonstration of intra-locus compensation using the ornithine transcarbamylase protein as model. (2007) (18)
- Macrophages stimulate gastric and colorectal cancer invasion through EGFR Y 1086 , c-Src, Erk1/2 and Akt phosphorylation (2014) (18)
- E-Cadherin ( CDH 1 ) and p 53 rather than SMAD 4 and Caspase-10 germline mutations contribute to genetic predisposition in Portuguese gastric cancer patients (2004) (18)
- Loss of Y chromosome in gastric carcinoma. Fact or artifact? (1992) (18)
- A novel CDH1 germline missense mutation in a sporadic gastric cancer patient in north-east of Italy (2013) (17)
- Helicobacter pylori's cholesterol uptake impacts resistance to docosahexaenoic acid. (2014) (17)
- Substantial reduction of the gastric carcinoma critical region at 6q16.3-q23.1. (1999) (17)
- Atomic force microscopy and graph analysis to study the P-cadherin/SFK mechanotransduction signalling in breast cancer cells. (2016) (17)
- Substantial reduction of the gastric carcinoma critical region at 6q16.3–q23.1 (1999) (17)
- Retinoblastoma gene structure and product expression in human gastric carcinomas. (1994) (17)
- p53 alterations in gastric carcinoma: a study of 56 primary tumors and 204 nodal metastases. (1994) (17)
- Dependence of Tensional Homeostasis on Cell Type and on Cell–Cell Interactions (2018) (16)
- KRAS signaling pathway alterations in microsatellite unstable gastrointestinal cancers. (2010) (16)
- MBD4 mutations are rare in gastric carcinomas with microsatellite instability. (2003) (16)
- Cervical Cytology Practice Guidelines (2001) (16)
- Pathology and Genetics of Familial Gastric Cancer (2010) (16)
- Helicobacter Pylori Targets the EPHA2 Receptor Tyrosine Kinase in Gastric Cells Modulating Key Cellular Functions (2020) (16)
- Cytogenetic study of a combined germ cell tumor of the testis. (1988) (16)
- Transcription initiation arising from E-cadherin/CDH1 intron2: a novel protein isoform that increases gastric cancer cell invasion and angiogenesis. (2012) (15)
- A subset of colorectal carcinomas express c-KIT protein independently of BRAF and/or KRAS activation (2007) (15)
- Mitochondrial DNA alteration in gastric cancer. (2000) (15)
- Different patterns of β‐catenin expression in gastric carcinomas: relationship with clinicopathological parameters and prognostic outcome (2002) (15)
- Genetics of hereditary diffuse gastric cancer: progress and future challenges. (2006) (15)
- KRAS mutations and anti-epidermal growth factor receptor therapy in colorectal cancer with lymph node metastases. (2009) (15)
- TP53 germline mutations in Portugal and genetic modifiers of age at cancer onset (2009) (15)
- The germline CDH1 c.48 G>C substitution contributes to cancer predisposition through generation of a pro-invasive mutation. (2014) (14)
- SRC inhibition prevents P-cadherin mediated signaling and function in basal-like breast cancer cells (2018) (14)
- New Target Genes in Endometrial Tumors Show a Role for the Estrogen‐Receptor Pathway in Microsatellite‐Unstable Cancers (2014) (14)
- Bilateral apocrine carcinoma of the breast Molecular and immunocytochemical evidence for two independent primary tumours (1998) (13)
- Quantification of topological features in cell meshes to explore E-cadherin dysfunction (2016) (13)
- Analysis of FMR1 and flanking microsatellite markers in normal and fragile X chromosomes in Portugal: evidence for a “protector” haplotype (1998) (12)
- Clonal cytogenetic abnormalities and telomeric associations in a fibroxanthoma of the stomach (1992) (12)
- PCR amplification of DNA obtained from archived hematoxylin‐eosin– and giemsa‐stained breast cancer aspirates (1998) (12)
- Targeting the PI3K Signalling as a Therapeutic Strategy in Colorectal Cancer. (2018) (11)
- Allelic gains and losses in distinct regions of chromosome 6 in gastric carcinoma. (2001) (11)
- Dissecting the signaling pathways associated with the oncogenic activity of MLK3 P252H mutation (2014) (11)
- Extended structural variation of a pentanucleotide repeat in the GSTP1 gene: characterisation in a normal population and in thyroid and gastric tumours (2000) (11)
- Loss of the Y chromosome in gastric carcinoma. Fact or artifact (1991) (11)
- Clinical and functional characterization of the CDH1 germline variant c.1679C>G in three unrelated families with hereditary diffuse gastric cancer (2018) (10)
- Specific inhibition of p110α subunit of PI3K: putative therapeutic strategy for KRAS mutant colorectal cancers (2016) (10)
- Geometric compensation applied to image analysis of cell populations with morphological variability: a new role for a classical concept (2018) (10)
- WNT-inducible signaling pathway protein 3, WISP-3, is mutated in microsatellite unstable gastrointestinal carcinomas but not in endometrial carcinomas. (2003) (10)
- S100P is a molecular determinant of E-cadherin function in gastric cancer (2019) (9)
- E-cadherin signal sequence disruption: a novel mechanism underlying hereditary cancer (2018) (9)
- Germline Missense Mutants in Hereditary Diffuse Gastric Cancer (2013) (8)
- Germline Missense Mutants in Hereditary Diffuse Gastric Cancer (2013) (8)
- Familial gastric carcinoma (2014) (8)
- A residual mature teratoma with a more balanced karyotype than the primary testicular nonseminoma? (1988) (8)
- [Prophylactic gastrectomy in patients with deleterious E-cadherin gene mutation]. (2001) (8)
- Gastric cancer in Europe. (2008) (7)
- 591 Lack of MicroRNA-101 Causes E-cadherin Functional Deregulation Through EZH2 Upregulation in Intestinal Gastric Cancer (2012) (7)
- Allele loss in human gastric carcinomas - relation to tumor progression and differentiation. (1995) (7)
- Bacterial protein azurin as a new candidate drug to treat untreatable breast cancers (2011) (6)
- An lmmunohistochemical study of ras oncoprotein expression in gastric carcinoma (1993) (6)
- ‘P‐cadherin functional role is dependent on E‐cadherin cellular context: a proof of concept using the breast cancer model’ (2016) (6)
- Proteomic Identification of a Gastric Tumor ECM Signature Associated With Cancer Progression (2022) (6)
- Integrin β1 orchestrates the abnormal cell-matrix attachment and invasive behaviour of E-cadherin dysfunctional cells (2021) (6)
- Impact of Microarray Technologies on Cytopathology (2001) (6)
- Germline CDH1 G212E Missense Variant: Combining Clinical, In Vitro and In Vivo Strategies to Unravel Disease Burden (2021) (5)
- DNAJB 4 molecular chaperone distinguishes WT from mutant E-cadherin , determining their fate in vitro and in vivo (2014) (5)
- E-Cadherin Radial Distribution Characterization for Mutation Detection Purposes (2013) (4)
- Novel expressed sequences obtained by means of a suppression subtractive hybridisation analysis from the 6q21 region that is frequently deleted in gastric cancer. (2002) (4)
- Fluorescence Imaging and Biological Quantification (2017) (4)
- Co-expression of E- and P-cadherin in breast cancer: role as an invasion suppressor or as an invasion promoter? (2010) (4)
- The Porto European Cancer Research Summit 2021 (2021) (4)
- CHAPTER 5 Estrogen , MSI and Lynch Syndrome-Associated Tumors (2009) (3)
- 712 ICI 182,780 induces p-cadherin overexpression in breast cancer cells through chromatin remodelling at the promoter level: role of C/EBPbeta in CDH3 gene activation (2010) (3)
- E-cadherin germline mutation carriers: clinical management and genetic implications (2014) (3)
- Familial gastric polyposis and diffuse carcinoma: a new hereditary gastric cancer syndrome not linked to E-cadherin (1999) (3)
- A machine learning approach for single cell interphase cell cycle staging (2021) (3)
- Classification of gastric carcinoma: from microscopy to molecular pathology (1999) (3)
- CDH1 structural alterations as novel prognostic biomarker in gastric cancer patients. (2011) (3)
- Re. ‘Cellular phenotypes of differentiated‐type adenocarcinomas and precancerous lesions of the stomach are dependent on the genetic pathways’ (2001) (2)
- Corrigendum: Quantification of topological features in cell meshes to explore E-cadherin dysfunction (2016) (2)
- 26 E-Cadherin and CagA Associate in a Tetrameric Complex That Suppresses Helicobacter pylori-Mediated Cell Invasion (2008) (2)
- Cytogenetic Analysis of Ten Human Seminomas 1 (2006) (2)
- Assessment of microsatellite alterations in young patients with gastric adenocarcinoma (1997) (2)
- Microsatellite instability in hepatocellular carcinomas from two different geographic regions (Portugal and Mozambique) (2003) (2)
- Corrigendum to “The germline CDH1 c.48 G > C substitution contributes to cancer predisposition through generation of a pro-invasive mutation” [Mutat. Res. 770 (2014) 106–111] (2015) (1)
- CHROMOSOMAL ANALYSIS IN THE DIAGNOSIS OF SOFT-TISSUE SARCOMAS (1989) (1)
- Correspondence re: A. E. Biemer-Huttmann et al., Mucin core protein expression in colorectal cancers with high levels of microsatellite instability indicates a novel pathway of morphogenesis. Clin. Cancer Res., 6: 1909-1916, 2000. (2000) (1)
- , Mucin Core Protein Expression in Colorectal Cancers with High Levels of Microsatellite Instability Indicates a Novel Pathway of Morphogenesis. (2000) (1)
- Advances in Brief Microsatellite Instability Is Associated with Tumors That Characterize the Hereditary Non-Polyposis Colorectal Carcinoma Syndrome 1 (2006) (1)
- LETTER TO THE EDITOR. Relationship between the expression of p53 and the aggressiveness of gastric carcinoma (1997) (1)
- Hereditary Diffuse Gastric Cancer and Other Gastric Cancers Associated with Hereditary Predisposition Syndromes (2013) (1)
- TTR Met 30 discordant for familial amyloid neuropathy ( FAP ) Two pairs of proven monozygotic twins (1999) (1)
- Capturing quantitative features of protein expression from in situ fluorescence microscopic images of cancer cell populations (2017) (1)
- their fate in vitro and in vivo (2013) (0)
- Oncogenic mutations in MAPK cascade as novel molecular biomarkers for treatment of gastric cancer patients with EGFR inhibitors. (2011) (0)
- SLUG down-regulates the expression of the tight junction proteins Occludin, Claudin-4 and Claudin-5 and confers invasive behavior to gastric carcinoma cells in an in vitro model (2008) (0)
- Deletion mapping of long arm of chromosome 6 in gastric carcinoma (1996) (0)
- E-cadherin spatial characterization with radial distribution profile for mutation detection (2012) (0)
- Genetic and immunohistochemical features of hyperplastic and adenomatous polyps of the stomach (1999) (0)
- PG 5.03 Molecular mechanisms in gastric cancer: Basis for therapy? (2012) (0)
- Abstract 4981: ICI182,780 induces P-cadherin upregulation in breast cancer cells through histone modifications at the promoter level: The role of C/EBPbeta inCDH3gene activation (2010) (0)
- Live, Attenuated and Engineered Bacterial Strains in the Treatment of Cancer (2010) (0)
- O riginal Paper Benign and Malignant Thyroid Lesions Show Instability at M icrosatellite Loci (1997) (0)
- Molecular characterization of deletions in chromosome 6 in human gastric carcinoma (1994) (0)
- Poster presentations: E-cadherin exon 3 is not a target region in MIN+ gastric carcinomas (1999) (0)
- E-cadherin mediated cellular effects and molecular partners. Gastric cancer as an invasive model (2010) (0)
- 1 Helicobacter pylori ’ s cholesterol uptake impacts resistance to 1 docosahexaenoic acid 2 (2019) (0)
- Relationship between c-erbB-2 and other markers of aggressiveness of gastric carcinoma (1992) (0)
- Dissecting the signaling pathways associated with the oncogenic activity of MLK3 P252H mutation (2014) (0)
- Genetic and histologic characterization of familial gastric polyposis (1991) (0)
- HMLH1 gene promoter methylation is the major cause of micro-satellite instability in gastric cancer (1999) (0)
- Crosstalk between WNT and Hippo signaling pathways is affected by cell density and loss of or mutated E-cadherin protein, associated to HDGC. (2016) (0)
- PIK3CA Gene Alterations in Human Cancers (2009) (0)
- E-cadherin signal sequence disruption: a novel mechanism underlying hereditary cancer (2018) (0)
- Fibroxanthoma of the stomach: Report on a case with cytogenetic abnormalities (1992) (0)
- Helicobacter pylori and Gastroduodenal Secretory Function (1996) (0)
- 1055 Bacterial Protein Azurin as a New Candidate Drug to Treat P-cadherin Overexpressing Breast Cancer (2012) (0)
- Quercetin luteolin and ursolic acid are potent inhibitors of proliferation in colorectal carcinoma cells: new therapeutic tools? (2008) (0)
- Familial gastric carcinoma FCarneiro (2014) (0)
- I(12P) NEGATIVE GERM-CELL TUMORS - A DIFFERENT GROUP (1989) (0)
- Activation of Laminin γ2 by Helicobacter pylori promotes invasion and survival of gastric cancer cells with E-cadherin defects. (2022) (0)
- Illuminating the cycle of life (2017) (0)
- Relationship of P53 Mutations in Laryngeal Cancer and Tobacco Smoking (2004) (0)
- Genetically determined syndromes of the gastrointestinal tract (2004) (0)
- Differential Impacts on Tensional Homeostasis of Gastric Cancer Cells Due to Distinct Domain Variants of E-Cadherin (2022) (0)
- Hereditary Gastric Cancer: A New Syndrome (2021) (0)
- 552: CDH3/P-cadherin is negatively regulated by TAp63 in a p53-dependent manner in breast cancer cells: Effects on P-cadherin-mediated invasion and self-renewal (2014) (0)
- The Hunt for New Target Genes in Endometrial Tumors Reveals the Involvement of the Estrogen-Receptor Pathway in Microsatellite Unstable Cancers (2009) (0)
- Germline mutations in the E-cadherin and TP53 genes, but not in HPP1 or RUNX3 are associated with genetic predisposition for gastric cancer (2004) (0)
- Clinical and functional characterization of the CDH1 germline variant c.1679C>G in three unrelated families with hereditary diffuse gastric cancer (2018) (0)
- 319 DNAJB4 Differentially Regulates WT and Mutant E-cadherin in Cancer (2012) (0)
- Cytogenetic analysis of 11 gastric carcinomas (1992) (0)
- Geometrical compensation for protein expression profiling in fluorescence microscopy (2013) (0)
- Microsatellite instability in gastric carcinogenesis (1996) (0)
- S100P is a molecular determinant of E-cadherin function in gastric cancer (2019) (0)
- 930: Effect of radiotherapy on macrophages (2014) (0)
- Matrix metalloproteases as maestros for the dual role of LPS- and IL-10-stimulated macrophages in cancer cell behaviour (2015) (0)
- 488 TAp63 Counteracts Invasive and Stem Cell Properties Mediated by P-cadherin in Breast Cancer Cells (2012) (0)
- 452 P-cadherin Activates Src-kinase – a New Signaling Pathway With Implications in Breast Cancer Progression (2012) (0)
- Abstract 5815: Nucleus positioning and composition dictate the invasion performance of E-cadherin mutant cells (2023) (0)
- An immunohistochemical study of ras oncoprotein expression in gastric carcinoma. (1994) (0)
- Non-CDH1-Associated Familial Gastric Cancer and Epigenetics Factors (2013) (0)
- Benign and Malignant Thyroid Lesions Show Instability (1997) (0)
- Cytogenetic study of 6 gastric adenocarcinomas (1991) (0)
- tive case, one would have additional evidence favoring the concept that mtDNA mutations may play a specific role in the tumorigenesis of intestinal-type gastric carcinomas. 1 (2000) (0)
- OC-0501: The role of radiotherapy on macrophages and on macrophage-cancer cell communication (2015) (0)
- P53 expression/mutation in gastric carcinomas (1992) (0)
- Identification of the Gene Underlying Congenital Short Bowel Syndrome, Pointing to Its Major Role in Intestinal Development (2011) (0)
- Geometric compensation applied to image analysis of cell populations with morphological variability: a new role for a classical concept (2018) (0)
- Dependence of Tensional Homeostasis on Cell Type and on Cell–Cell Interactions (2018) (0)
- SRC inhibition prevents P-cadherin mediated signaling and function in basal-like breast cancer cells (2018) (0)
- Pathology of inherited conditions (2004) (0)
- Adenoma of the ciliary bodyA pathologic and cytogenetic study (1992) (0)
- Foamy cell mesothelioma (2002) (0)
- C/EBPβ physical interaction with the CDH3 gene promoter. (2013) (0)
- Author Correction: Ionizing radiation modulates human macrophages towards a pro-inflammatory phenotype preserving their pro-invasive and pro-angiogenic capacities (2022) (0)
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