Raúl Rabadán
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Spanish biologist
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Raúl Rabadánbiology Degrees
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Computational Biology
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Evolutionary Biology
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Biology
Raúl Rabadán's Degrees
- PhD Biophysics University of Barcelona
- Bachelors Physics University of Barcelona
Why Is Raúl Rabadán Influential?
(Suggest an Edit or Addition)According to Wikipedia, Raúl Rabadán is a Spanish-American theoretical physicist and computational biologist. He is currently the Gerald and Janet Carrus Professor in the Department of Systems Biology, Biomedical Informatics and Surgery at Columbia University. He is the director of the Program for Mathematical Genomics at Columbia University and director of the Center for Topology of Cancer Evolution and Heterogeneity. At Columbia, he has put together a highly interdisciplinary lab with researchers from the fields of mathematics, physics, computer science, engineering, and medicine, with the common goal of solving pressing biomedical problems through quantitative computational models. Rabadan's current interest focuses on uncovering patterns of evolution in biological systems—in particular, viruses and cancer.
Raúl Rabadán's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma (2016) (1474)
- Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4. (2012) (979)
- Analysis of the Coding Genome of Diffuse Large B-Cell Lymphoma (2011) (929)
- Inactivating mutations of acetyltransferase genes in B-cell lymphoma (2010) (855)
- BRAF mutations in hairy-cell leukemia. (2011) (763)
- Transforming Fusions of FGFR and TACC Genes in Human Glioblastoma (2012) (647)
- Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation (2011) (643)
- Clonal evolution of glioblastoma under therapy (2016) (504)
- Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia. (2013) (480)
- Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas (2014) (467)
- Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma (2019) (463)
- Genetics of follicular lymphoma transformation. (2014) (458)
- The integrated landscape of driver genomic alterations in glioblastoma (2013) (442)
- Leukemogenesis Induced by an Activating β-catenin mutation in Osteoblasts (2014) (429)
- Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractoriness. (2011) (388)
- Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia. (2012) (364)
- RNA Exosome-Regulated Long Non-Coding RNA Transcription Controls Super-Enhancer Activity (2015) (354)
- Convergent mutations and kinase fusions lead to oncogenic STAT3 activation in anaplastic large cell lymphoma. (2015) (350)
- Geographic dependence, surveillance, and origins of the 2009 influenza A (H1N1) virus. (2009) (342)
- The coding genome of splenic marginal zone lymphoma: activation of NOTCH2 and other pathways regulating marginal zone development (2012) (336)
- Clinical impact of small TP53 mutated subclones in chronic lymphocytic leukemia. (2013) (320)
- The mutational landscape of cutaneous T cell lymphoma and Sézary syndrome (2015) (300)
- Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL (2013) (296)
- PHF6 mutations in T-cell acute lymphoblastic leukemia (2010) (264)
- Codon usage bias and the evolution of influenza A viruses. Codon Usage Biases of Influenza Virus (2010) (250)
- Genetic lesions associated with chronic lymphocytic leukemia transformation to Richter syndrome (2013) (250)
- Topology of viral evolution (2013) (250)
- Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers. (2017) (250)
- Patterns of Evolution and Host Gene Mimicry in Influenza and Other RNA Viruses (2008) (244)
- Whole-exome sequencing identifies somatic mutations of BCOR in acute myeloid leukemia with normal karyotype. (2011) (232)
- LONGITUDINAL MOLECULAR TRAJECTORIES OF DIFFUSE GLIOMA IN ADULTS (2019) (223)
- Heart and Skeletal Muscle Inflammation of Farmed Salmon Is Associated with Infection with a Novel Reovirus (2010) (218)
- Genetic Inactivation of the PRC2 Complex in T-Cell Acute Lymphoblastic Leukemia (2011) (214)
- Single-cell topological RNA-Seq analysis reveals insights into cellular differentiation and development (2017) (212)
- A Nondegenerate Code of Deleterious Variants in Mendelian Loci Contributes to Complex Disease Risk (2013) (197)
- Spatiotemporal genomic architecture informs precision oncology in glioblastoma (2017) (193)
- Disease-associated mutation in SRSF2 misregulates splicing by altering RNA-binding affinities (2015) (178)
- Highly Conserved Regions of Influenza A Virus Polymerase Gene Segments Are Critical for Efficient Viral RNA Packaging (2007) (164)
- The Egyptian Rousette Genome Reveals Unexpected Features of Bat Antiviral Immunity (2018) (162)
- Emergence of Fatal Avian Influenza in New England Harbor Seals (2012) (160)
- Drug-drug interaction through molecular structure similarity analysis (2012) (155)
- Mutational landscape, clonal evolution patterns, and role of RAS mutations in relapsed acute lymphoblastic leukemia (2016) (154)
- An NF-κB Transcription-Factor-Dependent Lineage-Specific Transcriptional Program Promotes Regulatory T Cell Identity and Function. (2017) (151)
- Noncoding RNA transcription targets AID to divergently transcribed loci in B cells (2014) (150)
- Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors (2019) (144)
- The origin of the recent swine influenza A(H1N1) virus infecting humans. (2009) (141)
- Pharmacogenomic landscape of patient-derived tumor cells informs precision oncology therapy (2018) (132)
- Pervasive mutations of JAK-STAT pathway genes in classical Hodgkin lymphoma. (2018) (130)
- Distinct Viral and Mutational Spectrum of Endemic Burkitt Lymphoma (2015) (126)
- The genetics of nodal marginal zone lymphoma. (2016) (125)
- The 2019 mathematical oncology roadmap (2019) (124)
- Comparison of Avian and Human Influenza A Viruses Reveals a Mutational Bias on the Viral Genomes (2006) (121)
- A targetable GATA2-IGF2 axis confers aggressiveness in lethal prostate cancer. (2015) (110)
- Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors (2018) (110)
- Mitochondrial DNA Haplogroup D4a Is a Marker for Extreme Longevity in Japan (2008) (96)
- A Structure-Informed Atlas of Human-Virus Interactions (2019) (93)
- Genetic lesions associated with chronic lymphocytic leukemia chemo-refractoriness. (2014) (89)
- Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations. (2021) (88)
- Somatic mutations and cell identity linked by Genotyping of Transcriptomes (2019) (87)
- Identification of a new subclass of ALK-negative ALCL expressing aberrant levels of ERBB4 transcripts. (2016) (86)
- Clonal evolution mechanisms in NT5C2 mutant relapsed acute lymphoblastic leukemia (2017) (84)
- Activating mutations and translocations in the guanine exchange factor VAV1 in peripheral T-cell lymphomas (2017) (83)
- Functional interrogation of DNA damage response variants with base editing screens (2021) (82)
- Transcriptomics Identify CD9 as a Marker of Murine IL-10-Competent Regulatory B Cells. (2015) (81)
- FBXW7 mutations in melanoma and a new therapeutic paradigm. (2014) (77)
- Quantitative Analysis of Immune Infiltrates in Primary Melanoma (2018) (75)
- MGMT genomic rearrangements contribute to chemotherapy resistance in gliomas (2020) (74)
- iPLA2β-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4 (2021) (72)
- Patterns of Oligonucleotide Sequences in Viral and Host Cell RNA Identify Mediators of the Host Innate Immune System (2009) (71)
- Differential levels of transcription of p53‐regulated genes by the arginine/proline polymorphism: p53 with arginine at codon 72 favors apoptosis (2010) (69)
- Biclustering of Adverse Drug Events in the FDA's Spontaneous Reporting System (2011) (69)
- Non‐random reassortment in human influenza A viruses (2008) (66)
- Tumor evolutionary directed graphs and the history of chronic lymphocytic leukemia (2014) (66)
- arcasHLA: high-resolution HLA typing from RNAseq (2019) (65)
- Facilitating adverse drug event detection in pharmacovigilance databases using molecular structure similarity: application to rhabdomyolysis (2011) (64)
- Comprehensive characterization of protein–protein interactions perturbed by disease mutations (2021) (63)
- Pegasus: a comprehensive annotation and prediction tool for detection of driver gene fusions in cancer (2014) (62)
- The miR-424(322)/503 cluster orchestrates remodeling of the epithelium in the involuting mammary gland (2014) (62)
- Genotyping of Transcriptomes links somatic mutations and cell identity (2019) (61)
- Disease-Causing Mutations in SF3B1 Alter Splicing by Disrupting Interaction with SUGP1. (2019) (61)
- Complete Regression of Advanced Pancreatic Ductal Adenocarcinomas upon Combined Inhibition of EGFR and C-RAF. (2019) (60)
- Evolutionary Dynamics of Pandemic Methicillin-Sensitive Staphylococcus aureus ST398 and Its International Spread via Routes of Human Migration (2017) (59)
- Oligonucleotide Motifs That Disappear during the Evolution of Influenza Virus in Humans Increase Alpha Interferon Secretion by Plasmacytoid Dendritic Cells (2011) (59)
- Viral reassortment as an information exchange between viral segments (2012) (58)
- Mutations of NOTCH 1 are an independent predictor of survival in chronic lymphocytic leukemia (2012) (58)
- Differences in Patient Age Distribution between Influenza A Subtypes (2009) (57)
- Glioma progression is shaped by genetic evolution and microenvironment interactions (2022) (56)
- The B-cell receptor controls fitness of MYC-driven lymphoma cells via GSK3β inhibition (2017) (53)
- Tissue-Resident Memory T Cells Mediate Immune Homeostasis in the Human Pancreas through the PD-1/PD-L1 Pathway (2019) (52)
- Mutations in the RNA splicing factor SF3B1 promote tumorigenesis through MYC stabilization. (2020) (52)
- Discovering Disease Associations by Integrating Electronic Clinical Data and Medical Literature (2011) (51)
- Reassortment Patterns in Swine Influenza Viruses (2009) (51)
- A single-cell atlas of the mouse and human prostate reveals heterogeneity and conservation of epithelial progenitors (2020) (49)
- Network Analysis of Global Influenza Spread (2010) (48)
- Blastic plasmacytoid dendritic cell neoplasm: genomics mark epigenetic dysregulation as a primary therapeutic target (2018) (48)
- Comprehensive characterisation of compartment-specific long non-coding RNAs associated with pancreatic ductal adenocarcinoma (2018) (46)
- Novel insights into the genetics and epigenetics of MALT lymphoma unveiled by next generation sequencing analyses (2019) (46)
- Inference of Ancestral Recombination Graphs through Topological Data Analysis (2015) (45)
- Nuclear Proximity of Mtr4 to RNA Exosome Restricts DNA Mutational Asymmetry (2017) (44)
- p53 Maintains Baseline Expression of Multiple Tumor Suppressor Genes (2017) (44)
- Longitudinal active sampling for respiratory viral infections across age groups (2019) (43)
- Clinical impact of small subclones harboring NOTCH1, SF3B1 or BIRC3 mutations in chronic lymphocytic leukemia (2016) (43)
- Rates of asymptomatic respiratory virus infection across age groups (2019) (41)
- Germ‐Cell‐Specific Inflammasome Component NLRP14 Negatively Regulates Cytosolic Nucleic Acid Sensing to Promote Fertilization (2017) (41)
- Topological Data Analysis Generates High-Resolution, Genome-wide Maps of Human Recombination. (2016) (41)
- Cluster analysis of the origins of the new influenza A(H1N1) virus. (2009) (40)
- Phf6 Loss Enhances HSC Self-Renewal Driving Tumor Initiation and Leukemia Stem Cell Activity in T-ALL. (2018) (40)
- The Long Noncoding RNA Paupar Modulates PAX6 Regulatory Activities to Promote Alpha Cell Development and Function. (2019) (40)
- A novel patient-derived tumorgraft model with TRAF1-ALK anaplastic large-cell lymphoma translocation (2014) (40)
- Genomic Characterization of Dysplastic Nevi Unveils Implications for Diagnosis of Melanoma. (2017) (40)
- Anomalies in the Influenza Virus Genome Database: New Biology or Laboratory Errors? (2008) (38)
- SAVI: a statistical algorithm for variant frequency identification (2013) (36)
- Generation of Live Attenuated Influenza Virus by Using Codon Usage Bias (2015) (36)
- Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors (2016) (35)
- De novo transcriptome reconstruction and annotation of the Egyptian rousette bat (2015) (35)
- Genetic similarity between cancers and comorbid Mendelian diseases identifies candidate driver genes (2015) (34)
- Recombination and lineage-specific mutations linked to the emergence of SARS-CoV-2 (2020) (34)
- Midkine rewires the melanoma microenvironment toward a tolerogenic and immune-resistant state (2020) (34)
- Data-driven discovery of seasonally linked diseases from an Electronic Health Records system (2014) (33)
- A MYC and RAS co-activation signature in localized prostate cancer drives bone metastasis and castration resistance (2020) (32)
- The Holdout Randomization Test: Principled and Easy Black Box Feature Selection (2018) (31)
- Single-cell characterization of macrophages in glioblastoma reveals MARCO as a mesenchymal pro-tumor marker (2021) (31)
- A Random Matrix Theory Approach to Denoise Single-Cell Data (2020) (30)
- Topological Data Analysis for Genomics and Evolution: Topology in Biology (2020) (30)
- E3-ubiquitin ligase Nedd4 determines the fate of AID-associated RNA polymerase II in B cells (2013) (29)
- The possibility of cancer immune editing in gliomas. A critical review (2018) (29)
- High-resolution Genomic Surveillance of 2014 Ebolavirus Using Shared Subclonal Variants (2014) (29)
- Increased HOXA5 expression provides a selective advantage for gain of whole chromosome 7 in IDH wild-type glioblastoma (2018) (29)
- Distinct genomic profile and specific targeted drug responses in adult cerebellar glioblastoma (2018) (29)
- Darwin or Lamarck? Future Challenges in Evolutionary Algorithms for Knowledge Discovery and Data Mining (2014) (28)
- An Information-Theoretic Analysis of Genetics, Gender and Age in Cancer Patients (2008) (28)
- The Contribution of the PB1-F2 Protein to the Fitness of Influenza A Viruses and its Recent Evolution in the 2009 Influenza A (H1N1) Pandemic Virus (2009) (27)
- Reprogramming Eukaryotic Translation with Ligand-Responsive Synthetic RNA Switches (2016) (27)
- Global Patterns of Recombination across Human Viruses (2021) (27)
- Assessment of T-cell receptor repertoire and clonal expansion in peripheral T-cell lymphoma using RNA-seq data (2015) (25)
- Copy number profiling across glioblastoma populations has implications for clinical trial design (2018) (25)
- Precision Medicine for Acute Kidney Injury (AKI): Redefining AKI by Agnostic Kidney Tissue Interrogation and Genetics. (2018) (25)
- Multiscale Topology of Chromatin Folding (2015) (25)
- Functional Data Analysis using a Topological Summary Statistic: the Smooth Euler Characteristic Transform (2016) (25)
- MutComFocal: an integrative approach to identifying recurrent and focal genomic alterations in tumor samples (2013) (25)
- Topological Data Analysis for Genomics and Evolution (2019) (25)
- GAB2 induces tumor angiogenesis in NRAS-driven melanoma (2013) (24)
- Frequency Analysis Techniques for Identification of Viral Genetic Data (2010) (24)
- Genomic characterization of HIV-associated plasmablastic lymphoma identifies pervasive mutations in the JAK-STAT pathway. (2020) (24)
- Identification of relevant genetic alterations in cancer using topological data analysis (2020) (23)
- Viral diversity and clonal evolution from unphased genomic data (2014) (23)
- Gata3-controlled nucleosome eviction drives Myc enhancer activity in T-cell development and leukemia. (2019) (22)
- Mutational and functional genetics mapping of chemotherapy resistance mechanisms in relapsed acute lymphoblastic leukemia (2020) (22)
- Moduli Spaces of Phylogenetic Trees Describing Tumor Evolutionary Patterns (2014) (22)
- Prognostic and therapeutic role of targetable lesions in B-lineage acute lymphoblastic leukemia without recurrent fusion genes (2016) (21)
- CD8+ T-cell-mediated immunoediting influences genomic evolution and immune evasion in murine gliomas (2019) (20)
- Inter‐ and intra‐patient clonal and subclonal heterogeneity of chronic lymphocytic leukaemia: evidences from circulating and lymph nodal compartments (2016) (20)
- Interrogation of Eukaryotic Stop Codon Readthrough Signals by in Vitro RNA Selection. (2019) (20)
- SF3B1 mutant-induced missplicing of MAP3K7 causes anemia in myelodysplastic syndromes (2020) (19)
- Pan-cancer analysis identifies mutations in SUGP1 that recapitulate mutant SF3B1 splicing dysregulation (2020) (19)
- Beyond NPM-anaplastic lymphoma kinase driven lymphomagenesis: alternative drivers in anaplastic large cell lymphoma (2013) (19)
- High tumor mutational burden and T-cell activation are associated with long-term response to anti-PD1 therapy in Lynch syndrome recurrent glioblastoma patient (2020) (18)
- Author Correction: Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma (2019) (18)
- Fractal-like Distributions over the Rational Numbers in High-throughput Biological and Clinical Data (2010) (18)
- Persistent Homology Based Characterization of the Breast Cancer Immune Microenvironment: A Feasibility Study (2020) (18)
- Signs of the 2009 Influenza Pandemic in the New York-Presbyterian Hospital Electronic Health Records (2010) (18)
- The Holdout Randomization Test for Feature Selection in Black Box Models (2018) (18)
- Parametric Inference using Persistence Diagrams: A Case Study in Population Genetics (2014) (17)
- Genetic mechanisms of HLA-I loss and immune escape in diffuse large B cell lymphoma (2021) (17)
- Pharmacogenomic analysis of patient-derived tumor cells in gynecologic cancers (2019) (17)
- Characterizing Scales of Genetic Recombination and Antibiotic Resistance in Pathogenic Bacteria Using Topological Data Analysis (2014) (16)
- A pan-cancer analysis of driver gene mutations, DNA methylation and gene expressions reveals that chromatin remodeling is a major mechanism inducing global changes in cancer epigenomes (2018) (16)
- ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma (2021) (16)
- Evolution of the Influenza A Virus: Some New Advances (2008) (16)
- Genomic data analysis in tree spaces (2016) (16)
- FYN–TRAF3IP2 induces NF-κB signaling-driven peripheral T-cell lymphoma (2021) (16)
- An information theoretic method to identify combinations of genomic alterations that promote glioblastoma. (2015) (15)
- Repurposing dasatinib for diffuse large B cell lymphoma (2019) (15)
- Quantifying Genetic Innovation: Mathematical Foundations for the Topological Study of Reticulate Evolution (2018) (15)
- Collider Bounds on Pseudoscalars Coupling to Gauge Bosons (2005) (15)
- A Phase I Study of the Combination of Pexidartinib and Sirolimus to Target Tumor-Associated Macrophages in Unresectable Sarcoma and Malignant Peripheral Nerve Sheath Tumors (2021) (14)
- The Coding Genome of Nodal Marginal Zone Lymphoma Reveals Recurrent Molecular Alterations of PTPRD and Other Jak/Stat Signaling Genes (2014) (14)
- Hypermutagenesis in untreated adult gliomas due to inherited mismatch mutations (2019) (14)
- Secretome analysis of patient-derived GBM tumor spheres identifies midkine as a potent therapeutic target (2019) (14)
- Evolutionary scalpels for dissecting tumor ecosystems. (2017) (14)
- A Recoding Method to Improve the Humoral Immune Response to an HIV DNA Vaccine (2008) (13)
- Darwin, Lamarck, or Baldwin: Applying Evolutionary Algorithms to Machine Learning Techniques (2014) (13)
- Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations. (2021) (13)
- Mutant SF3B1 promotes AKT and NF-kB driven mammary tumorigenesis. (2020) (13)
- Host Dependent Evolutionary Patterns and the Origin of 2009 H1N1 Pandemic Influenza (2010) (12)
- Transcriptome reconstruction and annotation of cynomolgus and African green monkey (2014) (12)
- Black Box FDR (2018) (12)
- Computing the Role of Alternative Splicing in Cancer. (2021) (12)
- Quantifying Pathogen Surveillance Using Temporal Genomic Data (2013) (12)
- Identification of potentially oncogenic alterations from tumor-only samples reveals Fanconi anemia pathway mutations in bladder carcinomas (2017) (12)
- Recombination and convergent evolution led to the emergence of 2019 Wuhan coronavirus (2020) (12)
- Reassortment patterns in Swine influenza viruses. (2009) (12)
- Can patient selection and neoadjuvant administration resuscitate PD-1 inhibitors for glioblastoma? (2019) (11)
- Topological Summaries of Tumor Images Improve Prediction of Disease Free Survival in Glioblastoma Multiforme (2016) (11)
- New Recurrently Mutated Genes in Classical Hodgkin Lymphoma Revealed By Whole-Exome Sequencing of Microdissected Tumor Cells (2016) (11)
- Topological Data Analysis of Single-cell Hi-C Contact Maps (2018) (11)
- A Case of T‐cell Acute Lymphoblastic Leukemia Relapsed As Myeloid Acute Leukemia (2016) (11)
- On Statistical Modeling of Sequencing Noise in High Depth Data to Assess Tumor Evolution (2017) (9)
- Identifying Hosts of Families of Viruses: A Machine Learning Approach (2011) (9)
- CD8+ T-cell–Mediated Immunoediting Influences Genomic Evolution and Immune Evasion in Murine Gliomas (2020) (9)
- Linking transcriptomic and imaging data defines features of a favorable tumor immune microenvironment and identifies a combination biomarker for primary melanoma. (2020) (9)
- High throughput droplet single-cell Genotyping of Transcriptomes (GoT) reveals the cell identity dependency of the impact of somatic mutations (2018) (9)
- A Novel JAK1 Mutant Breast Implant-Associated Anaplastic Large Cell Lymphoma Patient-Derived Xenograft Fostering Pre-Clinical Discoveries (2020) (9)
- Leukaemogenesis inducedbyanactivating b-catenin mutation in osteoblasts (2014) (9)
- Quasi-universality in single-cell sequencing data (2018) (8)
- CtIP-mediated DNA resection is dispensable for IgH class switch recombination by alternative end-joining (2020) (8)
- Transcriptional control of CBX5 by the RNA binding proteins RBMX and RBMXL1 maintains chromatin state in myeloid leukemia (2021) (8)
- Dose-response modeling in high-throughput cancer drug screenings: an end-to-end approach. (2018) (8)
- Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma (2019) (8)
- Genomic Characterization of HIV-Associated Plasmablastic Lymphoma Identifies Pervasive Mutations in the JAK–STAT Pathway (2020) (7)
- Molecular characterization of severe and mild cases of influenza A (H1N1) 2009 strain from Argentina. (2010) (7)
- How many neutrophils are enough (redux, redux)? (2012) (7)
- Subversion of Serotonin Receptor Signaling in Osteoblasts by Kynurenine Drives Acute Myeloid Leukemia (2022) (6)
- Quantifying Reticulation in Phylogenetic Complexes Using Homology (2015) (6)
- MREC: a fast and versatile framework for aligning and matching point clouds with applications to single cell molecular data (2020) (6)
- Understanding Coronavirus (2020) (6)
- Reassortment Patterns in Swine Influenza Viruses (2009) (6)
- A Fast Semi-Automatic Segmentation Tool for Processing Brain Tumor Images (2015) (6)
- Oncogenic Vav1-Myo1f induces therapeutically targetable macrophage-rich tumor microenvironment in peripheral T cell lymphoma (2022) (5)
- Network Propagation Reveals Novel Features Predicting Drug Response of Cancer Cell Lines (2016) (5)
- Identi fi cation of a new subclass of ALK-negative ALCL expressing aberrant levels of ERBB 4 transcripts (2015) (5)
- PDK1 Is Required for Maintenance of CD4+ Foxp3+ Regulatory T Cell Function (2021) (5)
- HLA Typing from RNA Sequencing and Applications to Cancer. (2020) (5)
- Host Dependent Evolutionary Patterns and the Origin of 2009 H1N1 Pandemic Influenza. (2010) (4)
- Abstract 3853: Humanized NOD/Scid/IL2g-/- tumor grafts recapitulate primary anaplastic large cell lymphoma. (2013) (4)
- arcasHLA: high resolution HLA typing from RNA seq (2018) (4)
- Small Subclones Harboring NOTCH1, SF3B1 or BIRC3 Mutations Are Clinically Irrelevant in Chronic Lymphocytic Leukemia (2014) (4)
- A persistent look at how tumours evade therapy (2021) (4)
- Recombination and lineage-specific mutations linked to the emergence of SARS-CoV-2 (2021) (4)
- Topology identifies emerging adaptive mutations in SARS-CoV-2 (2021) (3)
- Next Generation Syndromic Surveillance (2009) (3)
- Repurposing dasatinib for ibrutinib-resistant diffuse large B-Cell lymphoma (2017) (3)
- Identification of Dido1 Mutation Associated with Familial Myelodysplastic Syndrome (MDS)/Acute Myeloid Leukemia (AML) (2012) (3)
- HLA allele-specific expression loss in tumors can shorten survival and hinder immunotherapy (2020) (3)
- Erratum to Convergent Mutations and Kinase Fusions Lead to Oncogenic STAT3 Activation in Anaplastic Large Cell Lymphoma [Cancer Cell 27, 516-532] April 13, 2015 10.1016/j.ccell.2015.04.014 (2015) (3)
- Activating Mutations In Fyn Kinase In Peripheral T-Cell Lymphomas (2013) (3)
- The Contribution of the PB1-F2 Protein to the Fitness of Influenza A Viruses and its Recent Evolution in the 2009 Influenza A (H1N1) Pandemic Virus. (2009) (3)
- The UVSSA complex alleviates MYC-driven transcription stress (2021) (3)
- The Contribution of the PB1-F2 protein to the fitness of Influenza A viruses and its recent evolution in the 2009 Influenza A (H1N1) pandemic virus. (2009) (3)
- Young and Early Career Investigators: Report from a Global HIV Vaccine Enterprise Working Group (2010) (3)
- Double Empirical Bayes Testing (2020) (2)
- Loss of PBRM1 alters promoter histone modifications and activates ALDH1A1 to drive renal cell carcinoma. (2022) (2)
- Active surveillance documents rates of clinical care seeking due to respiratory illness (2020) (2)
- Recurrent Rhoa Mutations In Peripheral T-Cell Lymphoma (2013) (2)
- Understanding the Origins of a Pandemic Virus (2011) (2)
- ParMap, an Algorithm for the Identification of Complex Genomic Variations in Nextgen Sequencing Data (2010) (2)
- RNA Sequencing of Hodgkin Lymphoma Reed-Sternberg Cells Uncovers a Plasma Cell Signature and Escape from NK Cell Recognition (2019) (2)
- JAK-STAT in lymphoproliferative disorders (2015) (2)
- Multiscale reorganization of the genome following DNA damage facilitates chromosome translocations via nuclear actin polymerization (2022) (2)
- TOP2B Enzymatic Activity on Promoters and Introns Modulates Multiple Oncogenes in Human Gliomas (2019) (2)
- Computational structure prediction methods enable the systematic identification of oncogenic mutations (2022) (2)
- Dose-response modeling in high-throughput cancer drug screenings: A case study with recommendations for practitioners (2018) (2)
- Single-cell characterization of macrophages in glioblastoma reveals MARCO as a mesenchymal pro-tumor marker (2021) (2)
- Transcriptional activation of Cidec by PPAR-How many neutrophils are enough ( redux , redux ) ? (1)
- Inter-Host Reassortment Patterns in Swine Influenza Viruses (2009) (1)
- Targeting cancer associated fibroblasts in pancreatic ductal adenocarcinoma: Identification and characterization of therapeutic candidates (2015) (1)
- Preparedness for the prevention and control of influenza outbreaks on passenger ships in the EU: the SHIPSAN TRAINET (2009) (1)
- Summary of Common Misunderstandings (2020) (1)
- ParMap, an algorithm for the identification of small genomic insertions and deletions in nextgen sequencing data (2010) (1)
- How Does the COVID-19 Outbreak Compare to the SARS Outbreak in 2003? (2020) (1)
- Abstract A24: PBRM1 alteration in clear cell renal cell carcinoma increases tumorigenicity through ALDH1A1 upregulation (2016) (1)
- Abstract NG16: DoublePIK3CAmutations incisincrease oncogenicity and sensitivity to PI3Kα inhibitors (2020) (1)
- High Throughput Droplet Single-Cell Genotyping of Transcriptomes (GoT) Reveals the Cell Identity Dependency of the Transcriptional Output of Somatic Mutations (2018) (1)
- VAV1 Activating Mutations and Translocations in Peripheral T-Cell Lymphomas (2016) (1)
- Molecular Genetic Analysis of Myelodysplastic Syndromes (MDS) Patients with Ring Sideroblasts (RS); Independent Confirmation of Association of SF3B1 Mutations with Better Prognosis (2014) (1)
- Genome-Wide Analysis Reveals Frequent Inactivating Mutations of Acetyltransferase Genes In B-Cell Lymphoma (2010) (1)
- Neoadjuvant chemoradiation alters the immune microenvironment in pancreatic ductal adenocarcinoma (2022) (1)
- 91 Impact of ultra-fast ‘FLASH’ radiotherapy on single cell immunogenomics in diffuse intrinsic pontine glioma (DIPG) (2021) (1)
- Geometry and Topology of Genomic Data (2017) (1)
- Author Correction: Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma (2019) (1)
- A Unified Modular Framework to Incorporate Structural Dependency in Spatial Omics Data (2022) (1)
- Publisher Correction: ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma (2022) (1)
- Topological Data Analysis (2019) (1)
- Highly sensitive detection of small variants in multi-sample ultra-deep tumor sequencing (2017) (1)
- The Genome of Chronic Lymphocytic Leukemia (2010) (1)
- Abstract 5173: Identification of single-nucleotide variants by high-throughput RNA sequencing in endemic Burkitt Lymphoma (2014) (1)
- KINOMO: A non-negative matrix factorization framework for recovering intra- and inter-tumoral heterogeneity from single-cell RNA-seq data (2022) (1)
- Viral diversity and clonal evolution from unphased genomic data (2014) (1)
- Dimensionality Reduction, Manifold Learning, and Metric Geometry (2019) (1)
- Convergent Mutations and New Kinase Fusions Lead to Oncogenic STAT3 Activation in Anaplastic Large Cell Lymphoma (2014) (1)
- Oncogenes and Tumor Suppressors p 53 Maintains Baseline Expression of Multiple Tumor Suppressor Genes (2017) (1)
- Topological data analysis identifies emerging adaptive mutations in SARS-CoV-2 (2021) (1)
- Radiation therapy promotes unsaturated fatty acids to maintain survival of glioblastoma (2022) (1)
- Pharmacogenomic analysis of patient-derived tumor cells in gynecologic cancers (2019) (1)
- Data-driven discovery of seasonally linked diseases from an Electronic Health Records system (2014) (1)
- A Targetable Bone Marrow-Niche Axis for the Treatment of Acute Myeloid Leukemia (2021) (1)
- Author response: Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors (2016) (1)
- MTR-19A MACROPHAGE-/MICROGLIAL-RICH TUMOR MICROENVIRONMENT MIMICS PRONEURAL TO MESENCHYMAL TRANSITION IN GLIOBLASTOMA (2015) (0)
- Abstract 4486: Proof of principle for pharmacogenomic-guided precision oncology for pediatric malignancy (2023) (0)
- MREC: a fast and versatile framework for aligning and matching data with applications to single cell molecular data (2020) (0)
- PATH-51. DNA COPY NUMBER PROFILING ACROSS GLIOBLASTOMA POPULATIONS HAS IMPLICATIONS FOR CLINICAL TRIAL DESIGN (2018) (0)
- ARP2/3- and resection-coupled genome reorganization facilitates translocations (2021) (0)
- Abstract B11: Prognostic biomarkers in stage II-III melanoma (2020) (0)
- A transposase-derived gene required for human brain development (2023) (0)
- Basic Notions of Algebraic Topology (2019) (0)
- How Is the Coronavirus Changing? (2020) (0)
- P01.150 hypermutations in glioblastoma are associated with increased response to immunotherapy (2018) (0)
- 2003 - ACUTE MYELOID LEUKEMIA CELLS SEIZE SEROTONIN SIGNALING IN OSTEOBLASTS TO ENGRAFT AND PROLIFERATE (2019) (0)
- A Theory of Taxonomy (2016) (0)
- Spatiotemporal genomic architecture informs precision oncology in glioblastoma (2017) (0)
- Inverse agonists of RAR/RXR signaling as lineage-specific anti-tumor agents against human Adenoid Cystic Carcinoma. (2023) (0)
- DIPG-45. Radiation induces a robust interferon response in Diffuse Midline Glioma (DMG), improving the potential for combination immunotherapy (2022) (0)
- How Can We Treat the Virus and Prevent Infections? (2021) (0)
- Midkine rewires the melanoma microenvironment toward a tolerogenic and immune-resistant state (2020) (0)
- Clonal evolution of uveal melanoma metastases. (2018) (0)
- HHV-6 in the Lymphoma Microenvironment: Both Chicken and Egg? (2021) (0)
- DDIS-13. UNDERSTANDING GLIOBLASTOMA SUSCEPTIBILITY TO TOP2-TARGETING DRUGS FOR PERSONALIZED THERAPY (2018) (0)
- Topological Data Analysis beyond Genomics (2019) (0)
- Supplementary Material for “Predicting Clinical Outcomes in Glioblastoma: An Application of Topological and Functional Data Analysis” (2019) (0)
- Evolution, Trees, and Beyond (2019) (0)
- The Mutational Landscape of CTCL and Sezary Syndrome (2015) (0)
- Transcriptional Control of HP1a By the RNA Binding Proteins Rbmx/L1 Maintain Chromatin State in Myeloid Leukemia (2020) (0)
- On Statistical Modeling of Sequencing Noise in High Depth Data to Assess Tumor Evolution (2017) (0)
- Suggested Further Reading (2019) (0)
- Plenary Paper (2014) (0)
- Identification of a New Subclass of ALK Negative Anaplastic Large Cell Lymphoma Expressing Aberrant Levels of ERBB4 Transcripts (2014) (0)
- FULL TRANSCRIPTOME SEQUENCING OF SORTED HODGKIN AND REED‐STERNBERG CELLS REVEALS PLASMACYTIC DIFFERENTIATION: INSIGHTS INTO MECHANISMS OF ONCOGENESIS AND IMMUNE EVASION (2017) (0)
- Expression of Vav1-Myo1F Fusion Affects T-Cell Differentiation and Induces T-Cell Lymphoma (2020) (0)
- Correction: Secretome analysis of patient-derived GBM tumorspheres identifies midkine as a potent therapeutic target (2020) (0)
- 3061 – STROMAL CELL-TRIGGERED DOWNREGULATION OF THE NUCLEOPORIN (NUP) FAMILY DRIVES TRANSFORMATION OF MYELODYSPLASIA TO ACUTE MYELOID LEUKEMIA (2022) (0)
- Figure and Quotation Credits (2020) (0)
- Correlation of immune infiltration of cytotoxic T cells and activated microglia in glioblastoma (GBM) post anti-PD1 therapy with response. (2018) (0)
- LYMPHOID NEOPLASIA Identi fi cation of a new subclass of ALK-negative ALCL expressing aberrant levels of ERBB4 transcripts (2015) (0)
- Role of Vav1 Genomic Alterations in T-Cell Differentiation and Transformation in Peripheral T-Cell Lymphoma (2019) (0)
- Genetic Landscape and Gene Expression Profile of Chronic Lymphocytic Leukemia Patients with Ultra-Stable Disease (2016) (0)
- Abstract A44: Targeting cancer-associated fibroblasts in pancreatic ductal adenocarcinoma: Identification and characterization of therapeutic candidates (2015) (0)
- Abstract B005: Linking transcriptomic and imaging features of the melanoma tumor microenvironment (2019) (0)
- TMIC-68. EVALUATING FLASH AND CONVENTIONAL DOSE-RATE RADIATION AND IMMUNE RESPONSE WITH SINGLE-CELL SEQUENCING IN DIFFUSE MIDLINE GLIOMA (DMG) (2022) (0)
- Author Correction: Multiscale reorganization of the genome following DNA damage facilitates chromosome translocations via nuclear actin polymerization. (2023) (0)
- Abstract 4750: Transcriptome sequencing of the Reed-Sternberg cells of classical Hodgkin lymphoma (2015) (0)
- Introductory Editors' note (2017) (0)
- Abstract PO-41: Expression of Vav1-Myo1F fusion affects T-cell differentiation and induces T-cell lymphoma (2020) (0)
- The Emergence of 2009 H1N1 Pandemic Influenza (2011) (0)
- chronic lymphocytic leukemia are an independent predictor of survival in NOTCH1 Mutations of (2013) (0)
- How Did the COVID-19 Outbreak Start and Evolve? (2020) (0)
- How Is the Coronavirus Spreading (2020) (0)
- Abstract IA6: Misregulation of pre-mRNA splicing in cancer (2013) (0)
- Abstract 3917: DoublePIK3CAmutations incisenhance oncogene activation and sensitivity to PI3K alpha inhibitors in breast cancer (2019) (0)
- Pervasiveness of HLA allele-specific expression loss across tumor types (2023) (0)
- Abstract 2091: Quantitative compositional and spatial analysis of tumor microenvironment (TME) in primary melanoma (2018) (0)
- A Random Categorization Model for Hierarchical Taxonomies (2017) (0)
- Mechanisms of insertions at a DNA double-strand break (2022) (0)
- Running title : Basal p 53 activates multiple tumor suppressor genes 1 p 53 maintains baseline expression of multiple tumor suppressor genes (2017) (0)
- Mutational Landscape, Clonal Evolution Patterns and Role of RAS Mutations in Relapsed Acute Lymphoblastic Leukemia (2016) (0)
- Are There Therapeutic Options? (2020) (0)
- Mutations in the RNA Splicing Factor SF3B1 Promote Transformation through MYC Stabilization (2018) (0)
- Gene-08. Pharmacologic Modulation Of Myc And Pdgfra By Targeting Topoisomerase Ii On Gliomas (2017) (0)
- 872 Neoadjuvant chemoradiotherapy enhances T cell infiltration in pancreatic ductal adenocarcinoma but high percentage of regulatory T cells associates with poor survival (2020) (0)
- 460 SINGLE CELL RNA SEQUENCING ANALYSIS UNVEILS CANCER-ASSOCIATE FIBROBLASTS HETEROGENEITY IN INTRAHEPATIC CHOLANGIOCARCINOMA (2020) (0)
- Benchmarking of microbiome detection tools on RNA-seq synthetic databases according to diverse conditions (2023) (0)
- Pharmacogenomic landscape of patient-derived tumor cells informs precision oncology therapy (2018) (0)
- Health Risks of Accidents at Nuclear Power Plants (2011) (0)
- Abstract 5084: A multifaceted role of the Hedgehog pathway in modulating pancreatic ductal adenocarcinoma biology (2015) (0)
- Applying Topological Principles to Genomic Analysis: Topological data analysis helps to overcome difficulties that conventional tree-based phylogenetic analyses have with horizontal gene transfers (2015) (0)
- Comprehensive characterization of protein-protein interaction network perturbations by human disease mutations (2020) (0)
- Genomic analysis of early-stage lung cancer reveals a role for TP53 mutations in distant metastasis (2022) (0)
- Modeling Cancer Complexity (2015) (0)
- Checkpoint kinase 1/2 inhibition potentiates anti-tumoral immune response and sensitizes gliomas to immune checkpoint blockade (2023) (0)
- IMMU-42. CD8+ T-CELLS MEDIATE IMMUNOEDITING, AND INFLUENCE GENOTYPE, TUMOR ONCOGENIC PATHWAYS AND MICROENVIRONMENT DURING PROGRESSION OF MURINE GLIOMAS (2019) (0)
- Abstract B11: Understanding how the Hedgehog pathway mediates stromal desmoplasia in Pancreatic Ductal Adencarcinoma (2015) (0)
- Author response: Tumor evolutionary directed graphs and the history of chronic lymphocytic leukemia (2014) (0)
- WE‐D‐BRB‐03: Geometrization of Tumor Evolution (2015) (0)
- epithelium in the involuting mammary gland cluster orchestrates remodeling of the miR-424 ( 322 ) / 503 The Material Supplemental (2014) (0)
- Pexidartinib and Sirolimus Sarcoma Phase 1 1 A Phase 1 study of the combination of pexidartinib and sirolimus to target tumor associated macrophages in unresectable sarcoma and malignant peripheral nerve sheath tumors (2021) (0)
- How Does the COVID-19 Outbreak Compare to Seasonal and Pandemic Influenza? (2020) (0)
- GENE-17. TOP2B REGULATES CDK4 SPLICE VARIANTS IN GLIOMAS (2018) (0)
- Transcriptome reconstruction and annotation of cynomolgus and African green monkey (2014) (0)
- Single cell RNA sequencing and functional in vivo genetic manipulation reveal heterogeneity and tumor-promoting roles of cancer-associated fibroblasts in intrahepatic cholangiocarcinoma (2020) (0)
- A pan-cancer analysis of driver gene mutations, DNA methylation and gene expressions reveals that chromatin remodeling is a major mechanism inducing global changes in cancer epigenomes (2018) (0)
- Foreword by Series Editor (2020) (0)
- Identification of potentially oncogenic alterations from tumor-only samples reveals Fanconi anemia pathway mutations in bladder carcinomas (2017) (0)
- Somatic mutations and cell identity linked by Genotyping of Transcriptomes (2019) (0)
- Anomalies in the Influenza Virus Genome Database: New Biology or Laboratory Errors? (cid:1) † (2008) (0)
- FLASH and Conventional Radiation Induce Differential Immune Responses in Diffuse Intrinsic Pontine Glioma, Highlighting Potential for Combination Immunotherapy (2022) (0)
- Highly Conserved Regions of Influenza A Virus Polymerase Gene Segments Are Critical for Efficient Viral RNA Packaging (cid:1) (2008) (0)
- Abstract A21: Compound PIK3CA mutations support a mutational dose-response model for oncogene activation and response to PI3K inhibitor targeted therapy in breast cancer (2020) (0)
- Host Dependent Evolutionary Patterns and the Origin of 2009 H1N1 Pandemic Influenza: Alexander Solovyov*, Benjamin Greenbaum*, Gustavo Palacios, W. Ian Lipkin and Raul Rabadan (* Joint First Authors). (2010) (0)
- Oncogenes and Tumor Suppressors p53 Maintains Baseline Expression of Multiple Tumor Suppressor Genes (2017) (0)
- Abstract P3-03-01: DoublePIK3CAmutations incisdrive oncogene addiction and enhance sensitivity to PI3K alpha inhibitors in breast cancer (2020) (0)
- Editorial overview: Genomics and epigenomics (2018) (0)
- Phenotypic dissection of epithelial lineages and therapeutic manipulation of differentiation programs in human Adenoid Cystic Carcinomas (ACCs) (2022) (0)
- Assessment of T-cell receptor repertoire and clonal expansion in peripheral T-cell lymphoma using RNA-seq data (2017) (0)
- Longitudinal molecular trajectories of diffuse glioma in adults (2019) (0)
- Mechanisms of Therapeutic Response to Tipifarnib in a Mouse Model of Angioimmunoblastic T-Cell Lymphoma (2020) (0)
- Abstract 2798: High density of CD68+HLA-DR-macrophages in the stroma of primary melanoma correlates with an unfavorable immune microenvironment as assessed by Digital Spatial Profiling (2019) (0)
- Reprogramming Cancer Associated Fibroblasts as a therapeutic approach against Pancreatic Ductal Adenocarcinoma (2017) (0)
- Abstract 4595: Activating mutations in theNT5C2nucleotidase gene drive chemotherapy resistance in relapsed ALL. (2013) (0)
- Pregnancy Specific Glycoproteins: A Possible Mediator of Immune Tolerance of Cancers (2021) (0)
- Suppression of GATA3 Binding Drives Selective Abrogation of NOTCH1-MYC Enhancer Activity By Nucleosome Invasion in Thymocyte Development and Leukemia (2018) (0)
- chemo-refractoriness Genetic lesions associated with chronic lymphocytic leukemia (2014) (0)
- Correction: The UVSSA complex alleviates MYC-driven transcription stress (2023) (0)
- GENO-06A PAN-GLIOMA CHARACTERIZATION OF GENOMIC, EPIGENOMIC AND TRANSCRIPTOMIC ACTIVITIES REVEALS NOVEL RELATIONSHIPS BETWEEN HISTOLOGICAL SUBTYPES AND MOLECULAR SIGNATURES (2015) (0)
- Sequence analysis arcasHLA: high-resolution HLA typing from RNAseq (2020) (0)
- 2. mtDNA Haplogroup D4a is a Marker for Extreme Longevity in Japan (2009) (0)
- Expanded pressure-induced pain referral and generalised hyperalgesia in women with primary dysmenorrhea (2017) (0)
- A Structure Informed Atlas of Pan-Viral Interactions Reveals Features of Human Infection (2019) (0)
- Genomic landscape of virus-associated cancers (2023) (0)
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