Ravishankar Ramachandran
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Indian molecular biologist
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Ravishankar Ramachandranbiology Degrees
Biology
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Cell Biology
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Genetics
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Molecular Biology
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Biology
Ravishankar Ramachandran's Degrees
- Masters Biotechnology Delhi University
- Bachelors Biotechnology Delhi University
Why Is Ravishankar Ramachandran Influential?
(Suggest an Edit or Addition)According to Wikipedia, Ravishankar Ramachandran is an Indian molecular biologist and a senior principal scientist at the department of molecular and structural biology of the Central Drug Research Institute. Known for his studies on the molecular mechanisms of human pathogens such as Mycobacterium tuberculosis, Ramachandran is a DBT-nominated member of the Institutional Bio-Safety Committee of Babasaheb Bhimrao Ambedkar University. His studies have been documented by way of a number of articles and ResearchGate, an online repository of scientific articles has listed 142 of them. The Department of Biotechnology of the Government of India awarded him the National Bioscience Award for Career Development, one of the highest Indian science awards, for his contributions to biosciences, in 2010.
Ravishankar Ramachandran's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Mutational studies on HslU and its docking mode with HslV. (2000) (145)
- NAD+-dependent DNA Ligase (Rv3014c) from Mycobacterium tuberculosis (2005) (141)
- Mycobacterium tuberculosis NAD+-dependent DNA ligase is selectively inhibited by glycosylamines compared with human DNA ligase I (2005) (64)
- Functional interactions of HslV (ClpQ) with the ATPase HslU (ClpY) (2002) (63)
- Hsp70-1 from Plasmodium falciparum: protein stability, domain analysis and chaperone activity. (2009) (56)
- Medicarpin, a legume phytoalexin, stimulates osteoblast differentiation and promotes peak bone mass achievement in rats: evidence for estrogen receptor β-mediated osteogenic action of medicarpin. (2012) (56)
- NAD+‐dependent DNA ligase (Rv3014c) from Mycobacterium tuberculosis: Novel structure‐function relationship and identification of a specific inhibitor (2007) (51)
- Pathophysiological Mechanism of Bone Loss in Type 2 Diabetes Involves Inverse Regulation of Osteoblast Function by PGC-1α and Skeletal Muscle Atrogenes: AdipoR1 as a Potential Target for Reversing Diabetes-Induced Osteopenia (2015) (50)
- NAD+‐Dependent DNA Ligase: A novel target waiting for the right inhibitor (2008) (40)
- Characterization of Rv3868, an Essential Hypothetical Protein of the ESX-1 Secretion System in Mycobacterium tuberculosis* (2008) (40)
- Mechanistic insights from the crystal structures of a feast/famine regulatory protein from Mycobacterium tuberculosis H37Rv (2007) (37)
- Bile acid receptor agonist GW4064 regulates PPARγ coactivator-1α expression through estrogen receptor-related receptor α. (2011) (34)
- Mechanism of inhibition of the ATPase domain of human topoisomerase IIα by 1,4-benzoquinone, 1,2-naphthoquinone, 1,4-naphthoquinone, and 9,10-phenanthroquinone. (2012) (33)
- Structural biology of Mycobacterium tuberculosis proteins: the Indian efforts. (2011) (31)
- Isolation and characterization of the prokaryotic proteasome homolog HslVU (ClpQY) from Thermotoga maritima and the crystal structure of HslV. (2002) (29)
- Single Amino Acid Substitutions at Specific Positions of the Heptad Repeat Sequence of Piscidin-1 Yielded Novel Analogs That Show Low Cytotoxicity and In Vitro and In Vivo Antiendotoxin Activity (2016) (26)
- Crystal structures of the Mycobacterium tuberculosis secretory antigen alanine dehydrogenase (Rv2780) in apo and ternary complex forms captures “open” and “closed” enzyme conformations (2008) (25)
- Direct evidence for a glutamate switch necessary for substrate recognition: crystal structures of lysine epsilon-aminotransferase (Rv3290c) from Mycobacterium tuberculosis H37Rv. (2006) (25)
- Small molecule adiponectin receptor agonist GTDF protects against skeletal muscle atrophy (2017) (24)
- Identification of gallic acid based glycoconjugates as a novel tubulin polymerization inhibitors. (2016) (23)
- Piscidin-1-analogs with double L- and D-lysine residues exhibited different conformations in lipopolysaccharide but comparable anti-endotoxin activities (2017) (22)
- Identification of 1-[4-Benzyloxyphenyl)-but-3-enyl]-1H-azoles as New Class of Antitubercular and Antimicrobial Agents. (2013) (20)
- Characterization of the HslU chaperone affinity for HslV protease (2005) (20)
- M. tuberculosis Sliding β-Clamp Does Not Interact Directly with the NAD+ -Dependent DNA Ligase (2012) (17)
- Overexpression, purification and crystallization of lysine ∊-aminotransferase (Rv3290c) from Mycobacterium tuberculosis H37Rv (2006) (17)
- Solution-phase synthesis of a library of carbapeptide analogues based on glycosylamino acid scaffolds and their in silico screening and antimicrobial evaluation. (2009) (15)
- Crystal Structure of the Hexachlorocyclohexane Dehydrochlorinase (LinA-Type2): Mutational Analysis, Thermostability and Enantioselectivity (2012) (15)
- Ligand-induced structural transitions, mutational analysis, and 'open' quaternary structure of the M. tuberculosis feast/famine regulatory protein (Rv3291c). (2009) (14)
- A Novel Dimer-Tetramer Transition Captured by the Crystal Structure of the HIV-1 Nef (2011) (14)
- Crystal structure of the Bacillus anthracis nucleoside diphosphate kinase and its characterization reveals an enzyme adapted to perform under stress conditions (2009) (13)
- reply: Docking of components in a bacterial complex (2000) (12)
- Cloning, purification and comparative structural analysis of two hypothetical proteins from Mycobacterium tuberculosis found in the human granuloma during persistence and highly up-regulated under carbon-starvation conditions. (2008) (12)
- Identification of novel phenyl butenonyl C-glycosides with ureidyl and sulfonamidyl moieties as antimalarial agents. (2014) (12)
- Dynamics of Physical Interaction between HIV-1 Nef and ASK1: Identifying the Interacting Motif(S) (2013) (12)
- Synthesis, in silico screening and bioevaluation of dispiro-cycloalkanones as antitubercular and mycobacterial NAD+-dependent DNA ligase inhibitors (2011) (11)
- Leprosy drug clofazimine activates peroxisome proliferator-activated receptor-γ and synergizes with imatinib to inhibit chronic myeloid leukemia cells (2019) (11)
- Interactions of the M. tuberculosis UsfX with the cognate sigma factor SigF and the anti-anti sigma factor RsfA. (2009) (11)
- Exploring the positional importance of aromatic residues and lysine in the interactions of peptides with the Plasmodium falciparum Hsp70-1. (2010) (11)
- Characterization of EccA3, a CbbX family ATPase from the ESX-3 secretion pathway of M. tuberculosis. (2017) (10)
- Identification of in vitro inhibitors of Mycobacterium tuberculosis Lysine ε-aminotransferase by pharmacophore mapping and three-dimensional flexible searches (2008) (10)
- Thianthrene is a novel inhibitor of Leishmania donovani pteridine reductase 1 (PTR1) (2012) (9)
- Crystal Structure of Mycobacterium tuberculosis H37Rv AldR (Rv2779c), a Regulator of the ald Gene (2016) (9)
- Characterization of M. tuberculosis SerB2, an Essential HAD-Family Phosphatase, Reveals Novel Properties (2014) (9)
- The M. tuberculosis HAD phosphatase (Rv3042c) interacts with host proteins and is inhibited by Clofazimine (2016) (8)
- Phase III, Randomized, Double-blind, Placebo controlled trial of Efficacy, Safety and Tolerability of Antiviral drug Umifenovir vs Standard care of therapy in non-severe COVID-19 patients (2021) (8)
- Structural-functional diversity of malaria parasite's PfHSP70-1 and PfHSP40 chaperone pair gives an edge over human orthologs in chaperone-assisted protein folding. (2020) (8)
- The quaternary arrangement of HslU and HslV in a cocrystal: a response to Wang, Yale. (2001) (8)
- Tricyclic dihydrobenzoxazepine and tetracyclic indole derivatives can specifically target bacterial DNA ligases and can distinguish them from human DNA ligase I. (2015) (7)
- Cloning, expression, purification and crystallization of a transcriptional regulatory protein (Rv3291c) from Mycobacterium tuberculosis H37Rv. (2004) (7)
- Mycobacterium tuberculosis UsfX (Rv3287c) exhibits novel nucleotide binding and hydrolysis properties. (2008) (7)
- Biochemical and functional characterizations of tyrosine phosphatases from pathogenic and nonpathogenic mycobacteria: indication of phenyl cyclopropyl methyl-/phenyl butenyl azoles as tyrosine phosphatase inhibitors (2015) (7)
- NAD+-dependent DNA ligase (Rv3014c) from M. tuberculosis: Strategies for inhibitor design (2008) (7)
- Exploiting Bacterial DNA Repair Systems as Drug Targets: A Review of the Current Scenario with Focus on Mycobacteria (2014) (6)
- Mycobacterial protein tyrosine kinase, PtkA phosphorylates PtpA at tyrosine residues and the mechanism is stalled by the novel series of inhibitors (2019) (6)
- Cloning, overexpression, purification and preliminary X-ray analysis of a feast/famine regulatory protein (Rv2779c) from Mycobacterium tuberculosis H37Rv. (2014) (6)
- Protein kinase C-δ inhibitor, Rottlerin inhibits growth and survival of mycobacteria exclusively through Shikimate kinase. (2016) (6)
- M. tuberculosis class II apurinic/ apyrimidinic‐endonuclease/3′‐5′ exonuclease (XthA) engages with NAD+-dependent DNA ligase A (LigA) to counter futile cleavage and ligation cycles in base excision repair (2020) (5)
- Mycobacterium tuberculosis class II apurinic/apyrimidinic‐endonuclease/3′‐5′ exonuclease III exhibits DNA regulated modes of interaction with the sliding DNA β‐clamp (2015) (5)
- Synthesis and bioevaluation of aryl hydroxamates distinguishing between NAD+ and ATP-dependent DNA ligases (2012) (5)
- Overexpression, purification, crystallization and preliminary X-ray analysis of Rv2780 from Mycobacterium tuberculosis H37Rv. (2008) (5)
- [Fe–S] biogenesis and unusual assembly of the ISC scaffold complex in the Plasmodium falciparum mitochondrion (2021) (5)
- Overexpression, purification and crystallization of lysine epsilon-aminotransferase (Rv3290c) from Mycobacterium tuberculosis H37Rv. (2006) (5)
- Biochemical characterization and novel inhibitor identification of Mycobacterium tuberculosis Endonuclease VIII 2 (Rv3297) (2017) (4)
- Critical determinants for substrate recognition and catalysis in the M. tuberculosis class II AP-endonuclease/3'-5' exonuclease III. (2015) (4)
- Histone Chaperone Nucleophosmin Regulates Transcription of Key Genes Involved in Oral Tumorigenesis (2019) (4)
- Setomimycin as a potential molecule for COVID‑19 target: in silico approach and in vitro validation (2022) (4)
- Exploring the positional importance of aromatic residues and lysine in the interactions of peptides with the Plasmodium falciparum Hsp70-1. (2011) (4)
- Mycobacterium tuberculosis Endonuclease VIII 2 (Nei2) forms a prereplicative BER complex with DnaN: Identification, characterization, and disruption of complex formation (2021) (3)
- Rv3868 (EccA1), an essential component of the Mycobacterium tuberculosis ESX-1 secretion system, is thermostable. (2013) (3)
- Mutational analysis of Mycobacterium tuberculosis lysine ɛ-aminotransferase and inhibitor co-crystal structures, reveals distinct binding modes. (2015) (3)
- Erratum. Pathophysiological Mechanism of Bone Loss in Type 2 Diabetes Involves Inverse Regulation of Osteoblast Function by PGC-1α and Skeletal Muscle Atrogenes: AdipoR1 as a Potential Target for Reversing Diabetes-Induced Osteopenia. Diabetes 2015;64:2609–2623 (2017) (3)
- Estradiol overcomes adiponectin-resistance in diabetic mice by regulating skeletal muscle adiponectin receptor 1 expression (2021) (2)
- Structure based identification of first-in-class fragment inhibitors that target the NMN pocket of M. tuberculosis NAD+-dependent DNA Ligase A. (2020) (1)
- Purification, crystallization and preliminary structural analysis of nucleoside diphosphate kinase from Bacillus anthracis. (2007) (1)
- Severe Acute Respiratory Syndrome Coronavirus-2 genome sequence variations relate to morbidity and mortality in Coronavirus Disease-19 (2021) (1)
- Identification of active molecules against Mycobacterial Shikimate Kinase from Chemical library and their affinity with different domains (2020) (0)
- Crystal structure of HslV from Thermotoga maritima (2003) (0)
- Crystal structure of Mycobacterium avium SerB2 at pH 6.6 (2016) (0)
- Crystal structure of Mycobacterium avium SerB2 in complex with serine at catalytic (PSP) domain (2017) (0)
- Crystal Structure of a Hexachlorocyclohexane dehydrochlorinase (LinA) Type2 (2012) (0)
- Crystal structure of Mycobacterium avium SerB2 with serine present at slightly different position near ACT domain (2017) (0)
- Lysine aminotransferase from M. tuberculosis in bound PMP form (2006) (0)
- Correction to: Setomimycin as a potential molecule for COVID‑19 target: in silico approach and in vitro validation (2022) (0)
- Crystal structure of the HIV-1 Nef sequenced from a patient's sample (2011) (0)
- Lysine aminotransferase from M. tuberculosis in the internal aldimine form (2006) (0)
- Structural basis for domain rotation during adenylation of active site K123 and fragment library screening against NAD+ -dependent DNA ligase from Mycobacterium tuberculosis (2020) (0)
- Crystal structure of Pndk from Bacillus anthracis (2009) (0)
- Feast or famine regulatory protein (Rv3291c)from M. tuberculosis complexed with L-Phenylalanine (2007) (0)
- Crystal structure of Mycobacterium avium SerB2 mutant D343N/D347N (2016) (0)
- Crystal structure of Mycobacterium avium SerB2 in complex with serine at ACT domain (2017) (0)
- Biochemical and functional characterizations of tyrosine phosphatases from pathogenic and nonpathogenic mycobacteria: indication of phenyl cyclopropyl methyl-/phenyl butenyl azoles as tyrosine phosphatase inhibitors (2015) (0)
- Regulation of futile ligation during early steps of BER in M. tuberculosis is carried out by a β-clamp-XthA-LigA tri-component complex. (2022) (0)
- E243 mutant of M. tuberculosis Rv3290C (2009) (0)
- Crystal structure of Glu104Ala mutant (2009) (0)
- Crystal structure of T330S mutant of Rv3290c from M. tuberculosis (2009) (0)
- Crystal structure of a transcriptional regulator (2007) (0)
- Crystal structure of the M. tuberculosis Lysine-epsilon aminotransferase (Rv3290c) complexed to an inhibitor (2009) (0)
- M. tuberculosis Rv3291c complexed to Lysine (2009) (0)
- Crystal structure of Mycobacterium avium SerB2 mutant S275A/R279A at pH 6.6 with ethylene glycol bound at ACT- I domain (2016) (0)
- Adenylation domain of NAD+ dependent DNA ligase from M.tuberculosis (2005) (0)
- Lysine aminotransferase from M. tuberculosis in the internal aldimine form with bound substrate 2-ketoglutarate (2006) (0)
- Lysine Acetyltransferases (KATS) in Disguise: Diseases Implications. (2023) (0)
- N328A mutant of M. tuberculosis Rv3290c (2009) (0)
- Crystal Structure of MtbAldR (Rv2779c) (2015) (0)
- Crystal structure of Rv2780 from M. tuberculosis H37Rv (2008) (0)
- Histone chaperone Nucleophosmin regulates transcription of key genes involved in oral tumorigenesis (2022) (0)
- The M. tuberculosis HAD phosphatase (Rv3042c) interacts with host proteins and is inhibited by Clofazimine (2016) (0)
- Ternary complex of M. tuberculosis Rv2780 with NAD and pyruvate (2008) (0)
- Crystal structure of the M. tuberculosis beta clamp (2012) (0)
- Salt bridges at the subdomain interfaces of the adenylation domain and active-site residues of Mycobacterium tuberculosis NAD+-dependent DNA ligase A (MtbLigA) are important for the initial steps of nick-sealing activity. (2021) (0)
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