Rebecca Sitsapesan | Academic Influence

Rebecca Sitsapesan's AcademicInfluence.com Rankings

Rebecca Sitsapesan

Computer Science

#11831

World Rank

#12587

Historical Rank

Machine Learning

#5439

World Rank

#5511

Historical Rank

Artificial Intelligence

#5872

World Rank

#5962

Historical Rank

Database

#8912

World Rank

#9368

Historical Rank

computer-science Degrees

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Computer Science

Rebecca Sitsapesan's Degrees

PhD Computer Science University of California, Berkeley
Masters Computer Science Stanford University

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Why Is Rebecca Sitsapesan Influential?

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According to Wikipedia, Rebecca Sitsapesan was a professor and cardiac pharmacologist known for her work on single channel recording, ryanodine receptors and TRIC proteins. She was Professor of Pharmacology at the University of Oxford from 2013 to 2019, and Emeritus Professor from 2019 until her death in 2022.

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Rebecca Sitsapesan's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Mechanisms of caffeine activation of single calcium‐release channels of sheep cardiac sarcoplasmic reticulum. (1990) (280)
TPC2 Is a Novel NAADP-sensitive Ca2+ Release Channel, Operating as a Dual Sensor of Luminal pH and Ca2+* (2010) (204)
Cyclic ADP-ribose, the ryanodine receptor and Ca2+ release. (1995) (161)
Sheep cardiac sarcoplasmic reticulum calcium‐release channels: modification of conductance and gating by temperature. (1991) (160)
Regulation of Current Flow through Ryanodine Receptors by Luminal Ca2+ (1997) (148)
Evidence for Ca(2+) activation and inactivation sites on the luminal side of the cardiac ryanodine receptor complex. (2000) (147)
The Concise Guide to Pharmacology 2013/14: Overview (2013) (143)
Regulation of the gating of the sheep cardiac sarcoplasmic reticulum ca2+-release channel by luminal Ca2+ (1994) (141)
Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2) (2016) (134)
Light at the end of the Ca2+-release channel tunnel: structures and mechanisms involved in ion translocation in ryanodine receptor channels (2001) (128)
Cyclic ADP-ribose competes with ATP for the adenine nucleotide binding site on the cardiac ryanodine receptor Ca(2+)-release channel. (1994) (107)
Gating of the native and purified cardiac SR Ca(2+)-release channel with monovalent cations as permeant species. (1994) (92)
The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K (2018) (84)
TPC 2 Is a Novel NAADP-sensitive Ca 2 Release Channel , Operating as a Dual Sensor of Luminal pH and Ca 2 * (2010) (82)
Reconstituted Human TPC1 Is a Proton-Permeable Ion Channel and Is Activated by NAADP or Ca2+ (2014) (77)
Maximum Phosphorylation of the Cardiac Ryanodine Receptor at Serine-2809 by Protein Kinase A Produces Unique Modifications to Channel Gating and Conductance Not Observed at Lower Levels of Phosphorylation (2006) (75)
The gating of the sheep skeletal sarcoplasmic reticulum Ca2+-release channel is regulated by luminal Ca2+ (1995) (72)
Cyclic ADP-ribose and related compounds activate sheep skeletal sarcoplasmic reticulum Ca2+ release channel. (1995) (71)
The interactions of ATP, ADP, and inorganic phosphate with the sheep cardiac ryanodine receptor. (1998) (67)
FKBP12 Activates the Cardiac Ryanodine Receptor Ca2+-Release Channel and Is Antagonised by FKBP12.6 (2012) (66)
New insights into the gating mechanisms of cardiac ryanodine receptors revealed by rapid changes in ligand concentration. (1995) (48)
Effects of eicosapentaenoic acid on cardiac SR Ca(2+)-release and ryanodine receptor function. (2003) (42)
Modification of the Conductance and Gating Properties of Ryanodine Receptors by Suramin (1996) (39)
New and notable ion‐channels in the sarcoplasmic/endoplasmic reticulum: do they support the process of intracellular Ca2+ release? (2015) (38)
Synthesis of the Ca2+-mobilizing messengers NAADP and cADPR by intracellular CD38 enzyme in the mouse heart: Role in β-adrenoceptor signaling (2017) (37)
Charade of the SR K+-channel: two ion-channels, TRIC-A and TRIC-B, masquerade as a single K+-channel. (2010) (35)
Markovian models of low and high activity levels of cardiac ryanodine receptors. (2001) (35)
Stereospecific antiarrhythmic effect of opioid receptor antagonists in myocardial ischaemia (1986) (34)
The effects of drugs interacting with opioid receptors on the early ventricular arrhythmias arising from myocardial ischaemia (1989) (33)
The structure and function of ryanodine receptors (1998) (33)
Exploring the biophysical evidence that mammalian two‐pore channels are NAADP‐activated calcium‐permeable channels (2016) (32)
Structural factors that determine the ability of adenosine and related compounds to activate the cardiac ryanodine receptor (2000) (32)
Glycolytic pathway intermediates activate cardiac ryanodine receptors (1998) (31)
The antiarrhythmic and cardiac electrophysiological effects of buprenorphine (1989) (28)
DIDS modifies the conductance, gating, and inactivation mechanisms of the cardiac ryanodine receptor. (2002) (27)
TRIC channels supporting efficient Ca2+ release from intracellular stores (2013) (26)
Do Inactivation Mechanisms Rather than Adaptation Hold the Key to Understanding Ryanodine Receptor Channel Gating? (2000) (24)
From eggs to hearts: what is the link between cyclic ADP-ribose and ryanodine receptors? (2012) (24)
Similarities in the Effects of DIDS, DBDS and Suramin on Cardiac Ryanodine Receptor Function (1999) (22)
TRIC-B channels display labile gating: evidence from the TRIC-A knockout mouse model (2013) (21)
New and notable ion-channels in the sarcoplasmic/endoplasmic reticulum: do they support the process of intracellular Ca2+ release? (2015) (20)
Functional regulation of the cardiac ryanodine receptor by suramin and calmodulin involves multiple binding sites. (2004) (19)
FKBP12.6 Activates RyR1: Investigating the Amino Acid Residues Critical for Channel Modulation (2014) (19)
Effect of adrenaline on cardiac force-interval relationship. (1992) (18)
Quantitative RyR1 reduction and loss of calcium sensitivity of RyR1Q1970fsX16+A4329D cause cores and loss of muscle strength. (2019) (17)
Ca2+-Dependent Phosphorylation of RyR2 Can Uncouple Channel Gating from Direct Cytosolic Ca2+ Regulation (2011) (17)
Is there something fishy about the regulation of the ryanodine receptor in the fish heart? (2015) (16)
The ryanodine receptor provides high throughput Ca2+-release but is precisely regulated by networks of associated proteins: a focus on proteins relevant to phosphorylation. (2015) (14)
Dampened activity of ryanodine receptor channels in mutant skeletal muscle lacking TRIC‐A (2017) (14)
Evidence for novel caffeine and Ca2+ binding sites on the lobster skeletal ryanodine receptor (1999) (14)
Mitsugumin 23 Forms a Massive Bowl-Shaped Assembly and Cation-Conducting Channel (2011) (13)
Ca2+‐calmodulin can activate and inactivate cardiac ryanodine receptors (2009) (13)
Antagonism by adenosine and ATP of an isoprenaline-induced background current in guinea-pig ventricular myocytes. (1990) (13)
AMP is a partial agonist at the sheep cardiac ryanodine receptor (1999) (13)
Ca2+-calmodulin increases RyR2 open probability yet reduces ryanoid association with RyR2. (2009) (12)
Single-Channel Characterization of the Rabbit Recombinant RyR2 Reveals a Novel Inactivation Property of Physiological Concentrations of ATP (2008) (11)
Structural characteristics that govern binding to, and modulation through, the cardiac ryanodine receptor nucleotide binding site. (2003) (11)
Simvastatin activates single skeletal RyR1 channels but exerts more complex regulation of the cardiac RyR2 isoform (2018) (11)
Promiscuous attraction of ligands within the ATP binding site of RyR2 promotes diverse gating behaviour (2018) (9)
Removal of clustered positive charge from dihydropyridine receptor II-III loop peptide augments activation of ryanodine receptors. (2004) (8)
Subconductance Gating and Voltage Sensitivity of Sarcoplasmic Reticulum K+ Channels: A Modeling Approach (2015) (8)
Enhanced activity of multiple TRIC‐B channels: an endoplasmic reticulum/sarcoplasmic reticulum mechanism to boost counterion currents (2019) (8)
Diadenosine pentaphosphate is a potent activator of cardiac ryanodine receptors revealing a novel high‐affinity binding site for adenine nucleotides (2009) (5)
Increased open probability of sheep cardiac sarcoplasmic reticulum calcium-release channes induced by low temperatures (1990) (5)
A novel method for incorporation of ion channels into a planar phospholipid bilayer which allows solution changes on a millisecond timescale (1995) (5)
Cyclic ADP-Ribose Competes With ATP for the Adenine Nucleotide Binding Site on the Cardiac Ryanodine Receptor Ca2+-Release Channel (2005) (4)
In pursuit of ryanodine receptors gating in the plasma membrane of RINm5F pancreatic β-cells (2009) (4)
Luminal Ca2+ is a Major Sensitiser of Two-Pore Channels to NAADP (2010) (4)
Regulation of Ryanodine Receptor Channel Gating (1998) (3)
Polyunsaturated fatty acid-induced suppression of SR Ca2+ release (2003) (2)
Reconstitution of lysosomal ion channels into artificial membranes. (2015) (2)
TPC2 is a Novel NAADP-Sensitive Intracellular Ca2+-Release Channel with Unique Gating Characteristics (2011) (2)
Inhibition of cardiac and skeletal ryanodine receptors by the polyunsaturated fatty acid eicosapentaenoic acid (EPA) (2002) (2)
PROCEEDINGS OF THE PHYSIOLOGICAL SOCIETY (2013) (2)
Atorvastatin Activates Skeletal RyR1 Channels: Towards Reducing Statin Side-Effects (2018) (2)
FKBP12 and FKBP12.6 Exert Opposing Actions on the Single-Channel Behaviour of Both RyR1 and RyR2 (2010) (1)
The V2475F CPVT1 mutation yields distinct RyR2 channel populations that differ in their responses to cytosolic Ca2+ and Mg2+ (2021) (1)
Investigating the Relationship between FKBP Structure and the Ability to Activate RyR Channels (2013) (1)
Differential Effects of Temperature and Lipids on the Gating of RyR and SR K+ Channels (2016) (1)
Intracellular CD38 Mediates Cardiac Synthesis of NAADP and CADPR (2016) (1)
Statin activation of skeletal ryanodine receptors (RyR1) is a class effect but separable from HMG‐CoA reductase inhibition (2021) (1)
FKBP12 is a High Affinity, Reversible Activator of RyR2, and FKBP12.6 Antagonises Its Actions (2010) (1)
The ryanodine receptor mutational characteristics and its indication for cancer prognosis (2022) (1)
Quantitative RyR1 reduction and loss of calcium sensitivity of RyR1Q1970fsX16+A4329D cause cores and loss of muscle strength (2019) (1)
The effects of suramin and calmodulin on cardiac ryanodine receptor function (2001) (0)
Very high levels of S2809 phosphorylation are required to significantly alter RyR2 channel function (2005) (0)
Human TMEM16K (ANO10) A Target Enabling Package (TEP) (2020) (0)
Recombinant human TPC2 and TPC1 are both NAADP-regulated ion channels but display important functional differences (2015) (0)
H+ Inhibits TRIC-B Channels Derived from Mouse TRIC-A Knockout Tissue (2014) (0)
Diadenosine pentaphosphate activates the sheep cardiac ryanodine receptor at nanomolar concentrations (2004) (0)
Biophysical characteristics of TRIC-A and TRIC-B channels and their regulation of RYR2. (2021) (0)
Modelling the ATP Binding Site of RyR2 to Rationalise Ligand-Induced Gating Behaviour (2019) (0)
Simvastatin Activates Single Skeletal RyR1 Channels but Exerts More Complex Regulation of the Cardiac Isoform, RyR2 (2016) (0)
3245-Plat Calcium-Dependent Gating in MthK K D Channels Occurs at the Selectivity Filter (2014) (0)
Promiscuous attraction of ligands within the ATP binding site of RyR2 promotes diverse gating behaviour (2018) (0)
Voltage-Dependent Stochastic Gating Models of TRIC-B Channels (2013) (0)
Rapamycin is a Deceptive Tool for Probing Functional Interactions Between FK506-Binding Proteins and Ryanodine Receptors (2011) (0)
Voltage-dependent stochastic gating of TRIC-B channels derived from TRIC-A knockout mouse skeletal muscle (2013) (0)
The Malignant Hyperthermia G2435R Mutation Causes Constitutive RYR1 Openings (2021) (0)
Single-channel study of recombinant rabbit RyR2 identifies a novel inactivating property of ATP (2007) (0)
TRIC-B channels display labile gating: evidence from the TRIC-A knockout mouse model (2013) (0)
Sheep RyR2 channel activity is regulated by an endogenous kinase other than PKA or CaMKII; an effect not mediated by S2809 (2008) (0)
The effects of P1,P5-diadenosinc pentaphosphate (Ap5A) suggest novel high-affinity binding sites for adenine nucleotides on the cardiac ryanodine receptor (RyR2) (2007) (0)
Connecting Two-Pore Channel Structure with Single Channel Permeability Measurements (2015) (0)
Activation and inhibition of RyR gating by a DHPR II-III loop peptide (2002) (0)
Dampened Activity of Single Ryanodine Receptor Channels in Mice Devoid of TRIC-A (2016) (0)
Acta endocrinologica congress satellite symposium, St Göran's Hospital, Stockholm, Sweden, 26 June 1983 (1982) (0)
Calmodulin activates the cardiac ryanodine receptor (RyR2) and increases single-channel conductance at sub-activating Ca2+ levels. (2007) (0)
Two pore channels (TPC) are Ca2+-permeable, NAADP-activated ion-channels with marked sensitivity to luminal Ca2+ (2010) (0)
Simvastatin has Profound Effects on Sarcoplasmic Reticulum Ca2+ Leak in Skeletal but not Cardiac Muscle: A Mechanism for Myopathy (2016) (0)
Inactivation of the cardiac sarcoplasmic reticulum calcium-release channel by high calcium concentrations (1990) (0)
Cooperative Gating Among Ion-Channel Species in Junctional Sarcoplasmic Reticulum (2019) (0)
Probing the mechanism of ATP-dependent activation of RyR2 using triphosphate (2003) (0)
Impaired Ligand Regulation of Native RyR2 Channels in the Catecholaminergic Polymorphic Ventricular Tachycardia Mutation, RyR2-V2475F(+/−) (2019) (0)
SR K+ channels from TRIC-A knockout mice gate in a cooperative manner (2016) (0)
FKBP12 is a high affinity activator and FKBP12.6 is an antagonist of cardiac ryanodine receptor. (2012) (0)
A Homology Modelling Study of Potential RyR2 Structural Changes in R2474S and V2475F CPVT1 (2021) (0)
Ca2+-bound calmodulin (Ca2+CaM) activates the cardiac ryanodine receptor (RyR2) via a high affinity binding site and inhibits activity via a lower affinity site. (2007) (0)
Triphosphate is an effective activator of the sheep cardiac ryanodine receptor (2002) (0)
Effects of FKBP12 and FKBP12.6 on waves of Ca2+-induced Ca2+-release in isolated, permeabilised rat ventricular myocytes (2010) (0)
Synthesis of cADPR and NAADP by intracellular CD38 in heart: role in inotropic and arrhythmogenic effects of beta-adrenoceptor signaling (2016) (0)
PROCEEDINGS OF THE PHYSIOLOGICAL SOCIETY (2014) (0)
Opposing effects of FKBP12 and FKBP12.6 on the cardiac and skeletal isoforms of the ryanodine receptor (2010) (0)
Differential effects of statins on Ca2+ sparks in permeabilised rat skeletal and cardiac muscle: A mechanism for statin-induced myopathy (2016) (0)
The effects of calmodulin on the sheep cardiac ryanodine receptor (2002) (0)
Phosphorylation Activates RyR2 By Uncoupling The Channel From The Influence Of Cytosolic Ca2+ But Also Inhibits RyR2 By A Distinct Mechanism (2009) (0)
Knockdown of TRIC-B from tric-a-/-mice Alters Intracellular Ca2+ Signaling in Skeletal and Cardiac Muscles (2010) (0)
TRIC-B Channels Exhibit Labile Gating Properties; Evidence from TRIC-A Knockout Mice (2013) (0)
Exploring the Ca2+ sensitivity of modal gating of the cardiac Ca2+-release channel results in new Markovian models (2006) (0)
FKBP12.6 ‘Stabilises’ Cardiac SR Ca2+-Release by Antagonising High-Affinity Reversible Activation of RyR2 by FKBP12 (2011) (0)
Calmodulin regulation of the sheep cardiac ryanodine receptor is complex, involving modifications to both gating and conductance (2006) (0)
Use of Rapamycin Reveals Evidence of the Physiological Roles of FKBP12 and FKBP12.6 In Cardiac Excitation-Contraction Coupling (2010) (0)
High levels of phosphorylation at S2809 are required for significant increases in the P o of sheep cardiac ryanodine receptors. (2004) (0)
Adenosine and adenosine triphosphate antagonise the isoprenaline induced 6Na9o dependent inward current in guinea-pig ventricular myocytes*1 (1989) (0)
Irreversible activation of a sub-population of cardiac ryanodine receptor (RyR2) channels by Mg(2+)ATP. (2007) (0)
Single ryanodine receptor channels from the skeletal muscle of TRIC-A knockout mice show reduced activation by Mg2+ATP (2016) (0)
A new look at structures and mechanisms regulating endoplasmic/sarcoplasmic reticulum Ca2+ release in health and disease (2015) (0)
Phosphorylation of the sheep cardiac ryanodine receptor modifies both gating and conductance (2005) (0)
TRIC channels supporting efficient Ca2+ release from intracellular stores (2012) (0)
Cardiac and skeletal sarcoplasmic reticulum K+ channels from TRIC-A knockout mice show distinct gating characteristics to those derived from wild type mice (2016) (0)
The TRIC-A knockout mouse model provides insight into the labile gating nature of TRIC-B channels (2012) (0)
Statins Bind to Cardiac Ryanodine Receptor (RyR2) Channels to Alter Opening Frequency (2018) (0)
Single-channel characterisation of the trimeric intracellular (TRIC) membrane proteins reveals the identity of the sarcoplasmic reticulum K+-channel (2010) (0)
Critical role of TRIC-channels: What can be revealed by single-channel studies? (2014) (0)
The capacity to modulate ryanodine receptor channel gating by FK506-binding proteins is contained within three amino acid residues (2012) (0)
TPC1 is a Proton Permeable Channel that can be Independently Activated by Cytosolic Calcium or NAADP (2014) (0)
Electrophysiological Comparison of TRIC-A and TRIC-B, Two Trimeric Intracellular Cation Channels Associated with Intracellular Ca2+-Stores (2009) (0)
Mitsugumin23, a Protein Associated with Intracellular Calcium Stores, Behaves as an Ion-Channel that can Conduct Calcium (2011) (0)
Adenine nucleotide structure and the modulation of cardiac RyR channel gating. (2002) (0)
Simvastatin differentially modulates single cardiac and skeletal ryanodine receptor channels (2016) (0)
An Overview of Ryanodine Receptor Structure and Function (1998) (0)

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