Rebecca A. Taub

Rebecca A. Taub's AcademicInfluence.com Rankings

Rebecca A. Taub

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#12327

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#7325

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Philosophy

Rebecca A. Taub's Degrees

PhD Biomedical Sciences University of California, San Francisco
Doctorate Medicine Stanford University

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Rebecca A. Taub's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Liver Failure and Defective Hepatocyte Regeneration in Interleukin-6-Deficient Mice (1996) (1510)
Liver regeneration: from myth to mechanism (2004) (1464)
Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells. (1982) (1328)
The human c-myc oncogene: Structural consequences of translocation into the igh locus in Burkitt lymphoma (1983) (600)
Translocations among antibody genes in human cancer. (1983) (569)
Increased toxin‐induced liver injury and fibrosis in interleukin‐6–deficient mice (2000) (310)
Rapid activation of the stat3 transcription complex in liver regeneration (1995) (306)
Transcriptional control of liver regeneration (1996) (299)
Interleukin-6 Protects against Fas-mediated Death by Establishing a Critical Level of Anti-apoptotic Hepatic Proteins FLIP, Bcl-2, and Bcl-xL* (2001) (296)
STAT3 Contributes to the Mitogenic Response of Hepatocytes during Liver Regeneration* (2002) (295)
The network of glucokinase-expressing cells in glucose homeostasis and the potential of glucokinase activators for diabetes therapy. (2006) (289)
PRL-1, a unique nuclear protein tyrosine phosphatase, affects cell growth (1994) (264)
Activation and somatic mutation of the translocated c-myc gene in Burkitt lymphoma cells (1984) (263)
Resmetirom (MGL-3196) for the treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial (2019) (262)
CCAAT enhancer- binding protein beta is required for normal hepatocyte proliferation in mice after partial hepatectomy. (1998) (261)
Anti-inflammatory therapeutics for the treatment of atherosclerosis (2011) (256)
Rapid activation of post-hepatectomy factor/nuclear factor kappa B in hepatocytes, a primary response in the regenerating liver. (1994) (222)
The immediate-early growth response in regenerating liver and insulin-stimulated H-35 cells: comparison with serum-stimulated 3T3 cells and identification of 41 novel immediate-early genes (1991) (218)
A monoclonal antibody against the platelet fibrinogen receptor contains a sequence that mimics a receptor recognition domain in fibrinogen. (1989) (211)
Hepatoprotection via the IL-6/Stat3 pathway. (2003) (203)
Induction patterns of 70 genes during nine days after hepatectomy define the temporal course of liver regeneration. (1993) (203)
Interactions among LRF-1, JunB, c-Jun, and c-Fos define a regulatory program in the G1 phase of liver regeneration (1992) (192)
Antibodies to human c-myc oncogene product: evidence of an evolutionarily conserved protein induced during cell proliferation. (1984) (159)
A Multicomponent Insulin Response Sequence Mediates a Strong Repression of Mouse Glucose-6-phosphatase Gene Transcription by Insulin* (1997) (150)
Transcriptional regulatory signals define cytokine-dependent and -independent pathways in liver regeneration. (1999) (149)
Characterization of Induction of Protooncogene c-myc and Cellular Growth in Human Vascular Smooth Muscle Cells by Insulin and IGF-I (1989) (147)
Treatment With 5-Lipoxygenase Inhibitor VIA-2291 (Atreleuton) in Patients With Recent Acute Coronary Syndrome (2010) (144)
Identification of Acyl Coenzyme A:Monoacylglycerol Acyltransferase 3, an Intestinal Specific Enzyme Implicated in Dietary Fat Absorption* (2003) (141)
Coexpression of IL‐6 and soluble IL‐6R causes nodular regenerative hyperplasia and adenomas of the liver (1998) (141)
High levels of glucose-6-phosphatase gene and protein expression reflect an adaptive response in proliferating liver and diabetes. (1995) (138)
RNR-1, a nuclear receptor in the NGFI-B/Nur77 family that is rapidly induced in regenerating liver. (1993) (136)
Identification of LRF-1, a leucine-zipper protein that is rapidly and highly induced in regenerating liver. (1991) (133)
Interleukin-6-Induced STAT3 and AP-1 Amplify Hepatocyte Nuclear Factor 1-Mediated Transactivation of Hepatic Genes, an Adaptive Response to Liver Injury (2001) (132)
Interleukin‐6 from intrahepatic cells of bone marrow origin is required for normal murine liver regeneration (2002) (129)
Rapid induction in regenerating liver of RL/IF-1 (an I kappa B that inhibits NF-kappa B, RelB-p50, and c-Rel-p50) and PHF, a novel kappa B site-binding complex (1992) (128)
A variant translocation places the λ immunoglobulin genes 3′ to the c-myc oncogene in Burkitt's lymphoma (1984) (120)
Variable amplification of immunoglobulin λ light-chain genes in human populations (1983) (119)
Massive hepatic apoptosis associated with TGF-beta1 activation after Fas ligand treatment of IGF binding protein-1-deficient mice. (2003) (118)
Immediate-early gene expression differs between regenerating liver, insulin-stimulated H-35 cells, and mitogen-stimulated Balb/c 3T3 cells. Liver-specific induction patterns of gene 33, phosphoenolpyruvate carboxykinase, and the jun, fos, and egr families. (1990) (115)
Insulin as a growth factor in rat hepatoma cells. Stimulation of proto-oncogene expression. (1987) (113)
A high‐fat diet impairs liver regeneration in C57BL/6 mice through overexpression of the NF‐κB inhibitor, IκBα (2005) (112)
Global changes in interleukin‐6–dependent gene expression patterns in mouse livers after partial hepatectomy (2001) (111)
Impaired Hepatocyte DNA Synthetic Response Posthepatectomy in Insulin-Like Growth Factor Binding Protein 1-Deficient Mice with Defects in C/EBPβ and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Regulation (2003) (108)
The gene encoding rat insulinlike growth factor-binding protein 1 is rapidly and highly induced in regenerating liver (1991) (108)
Extremes of Clinical and Enzymatic Phenotypes in Children With Hyperinsulinism Caused by Glucokinase Activating Mutations (2009) (99)
Interleukin-6 protects hepatocytes from CCl4-mediated necrosis and apoptosis in mice by reducing MMP-2 expression. (2005) (99)
Novel delayed-early and highly insulin-induced growth response genes. Identification of HRS, a potential regulator of alternative pre-mRNA splicing. (1993) (98)
Insights into the Structure and Regulation of Glucokinase from a Novel Mutation (V62M), Which Causes Maturity-onset Diabetes of the Young* (2005) (97)
Carbon Flux via the Pentose Phosphate Pathway Regulates the Hepatic Expression of the Glucose-6-phosphatase and Phosphoenolpyruvate Carboxykinase Genes in Conscious Rats* (1998) (92)
Up-regulated Transcriptional Repressors SnoN and Ski Bind Smad Proteins to Antagonize Transforming Growth Factor-β Signals during Liver Regeneration* (2002) (92)
A novel alteration in the structure of an activated c-myc gene in a variant t(2;8) burkitt lymphoma (1984) (92)
Matrix metalloproteinase–activated doxorubicin prodrugs inhibit HT1080 xenograft growth better than doxorubicin with less toxicity (2005) (90)
Coexistence of C/EBP alpha, beta, growth-induced proteins and DNA synthesis in hepatocytes during liver regeneration. Implications for maintenance of the differentiated state during liver growth. (1995) (87)
Molecular analysis of the fructose transporter gene (GLUT5) in isolated fructose malabsorption. (1996) (85)
ATF-7, a Novel bZIP Protein, Interacts with the PRL-1 Protein-tyrosine Phosphatase* (2001) (80)
Discovery of 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β agonist in clinical trials for the treatment of dyslipidemia. (2014) (79)
Inhibition of Tumor Necrosis Factor-α-Converting Enzyme by a Selective Antagonist Protects Brain from Focal Ischemic Injury in Rats (2004) (77)
Activation of interleukin-6/STAT3 and liver regeneration following transplantation. (2001) (75)
From Clinicogenetic Studies of Maturity-Onset Diabetes of the Young to Unraveling Complex Mechanisms of Glucokinase Regulation (2006) (74)
HRS/SRp40-mediated inclusion of the fibronectin EIIIB exon, a possible cause of increased EIIIB expression in proliferating liver (1997) (72)
Hepatic jagged1 expression studies (1999) (70)
Lipid lowering in healthy volunteers treated with multiple doses of MGL-3196, a liver-targeted thyroid hormone receptor-β agonist. (2013) (68)
Cloning, human chromosomal assignment, and adipose and hepatic expression of the CL-6/INSIG1 gene. (1997) (66)
Promoter-specific trans-activation and inhibition mediated by JunB. (1993) (64)
Characterization of the promoter region and 3' end of the human insulin receptor gene. (1989) (64)
Normal liver regeneration in p50/nuclear factor κB1 knockout mice (2001) (63)
A high-fat diet impairs liver regeneration in C57BL/6 mice through overexpression of the NF-kappaB inhibitor, IkappaBalpha. (2005) (62)
Receptor Occupancy of Nonpeptide Corticotropin-Releasing Factor 1 Antagonist DMP696: Correlation with Drug Exposure and Anxiolytic Efficacy (2003) (59)
Cytologically balanced t(2;20) in a two-generation family with alagille syndrome: cytogenetic and molecular studies. (1994) (59)
Mapping of the human Blym-1 transforming gene activated in Burkitt lymphomas to chromosome 1. (1984) (57)
Mitogenic Up-regulation of the PRL-1 Protein-tyrosine Phosphatase Gene by Egr-1 (1999) (57)
Anxiolytic-Like Effects of the Corticotropin-Releasing Factor1 (CRF1) Antagonist DMP904 [4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1,5-a]-pyrimidine] Administered Acutely or Chronically at Doses Occupying Central CRF1 Receptors in Rats (2004) (55)
Localization of the beta-globin gene by chromosomal in situ hybridization. (1984) (54)
A Glucose Sensor Role for Glucokinase in Anterior Pituitary Cells (2006) (52)
Expression of PRL-1 nuclear PTPase is associated with proliferation in liver but with differentiation in intestine. (1996) (49)
A phase 2 randomized, double-blind, placebo-controlled study of the effect of VIA-2291, a 5-lipoxygenase inhibitor, on vascular inflammation in patients after an acute coronary syndrome. (2015) (49)
A translocated human c-myc oncogene is altered in a conserved coding sequence. (1986) (48)
Blocking NF‐κB in the liver: The good and bad news (1998) (48)
Rapid induction of mRNAs for liver regeneration factor and insulin‐like growth factor binding protein‐1 in primary cultures of rat hepatocytes by hepatocyte growth factor and epidermal growth factor (1994) (46)
Inhibition of tumor necrosis factor-alpha-converting enzyme by a selective antagonist protects brain from focal ischemic injury in rats. (2004) (46)
Molecular analysis of 24 Alagille syndrome families identifies a single submicroscopic deletion and further localizes the Alagille region within 20p12. (1995) (45)
Sepsis-induced depression of rat glucose-6-phosphatase gene expression and activity. (1997) (43)
Functional validation of ligand mimicry by anti-receptor antibodies: structural and therapeutic implications. (1992) (43)
I kappa B alpha can localize in the nucleus but shows no direct transactivation potential. (1993) (41)
Peptide sequences from the hypervariable regions of two monoclonal anti-idiotypic antibodies against the thyrotropin (TSH) receptor are similar to TSH and inhibit TSH-increased cAMP production in FRTL-5 thyroid cells. (1992) (41)
Insulin-Receptor Gene and Its Expression in Patients With Insulin Resistance (1989) (40)
Coexpression of liver‐specific and growth‐induced genes in perinatal and regenerating liver: Attainment and maintenance of the differentiated state during rapid proliferation (1995) (40)
Physiologic turnover of nuclear factor kappa B by nuclear proteolysis. (1994) (39)
Increased expression of cytokine-induced neutrophil chemoattractant in septic rat liver. (1995) (38)
Structure and localization of the IGFBP‐1 gene and its expression during liver regeneration (1994) (38)
Effects of Resmetirom on Noninvasive Endpoints in a 36‐Week Phase 2 Active Treatment Extension Study in Patients With NASH (2021) (37)
Mechanistic features associated with induction of metalloproteinases in human gingival fibroblasts by interleukin-1. (1994) (36)
Discovery of orally active carboxylic acid derivatives of 2-phenyl-5-trifluoromethyloxazole-4-carboxamide as potent diacylglycerol acyltransferase-1 inhibitors for the potential treatment of obesity and diabetes. (2011) (35)
MGL-3196, a selective thyroid hormone receptor-beta agonist significantly decreases hepatic fat in NASH patients at 12 weeks, the primary endpoint in a 36 week serial liver biopsy study (2018) (35)
6-Hydroxybuspirone Is a Major Active Metabolite of Buspirone: Assessment of Pharmacokinetics and 5-Hydroxytryptamine1A Receptor Occupancy in Rats (2007) (34)
Sugar binding to recombinant wild-type and mutant glucokinase monitored by kinetic measurement and tryptophan fluorescence. (2008) (33)
Anti-idiotypic antibodies against an antibody to the platelet glycoprotein (GP) IIb-IIIa complex mimic GP IIb-IIIa by recognizing fibrinogen. (1992) (32)
STAT 3 Contributes to the Mitogenic Response of Hepatocytes during Liver Regeneration * (2002) (30)
Liver regeneration in health and disease. (1996) (30)
CCAAT Enhancer – binding Protein b Is Required for Normal Hepatocyte Proliferation in Mice after Partial Hepatectomy (1998) (27)
Altered expression and function of the insulin receptor in a family with lipoatrophic diabetes. (1988) (26)
The Gene Encoding Human Nuclear Protein Tyrosine Phosphatase, PRL-1 (1998) (26)
Posttranscriptional mechanisms account for differences in steady state levels of insulin receptor messenger RNA in different cells. (1991) (25)
Normal liver regeneration in p50/nuclear factor kappaB1 knockout mice. (2001) (24)
Transcriptional up-regulation of the delayed early gene HRS/SRp40 during liver regeneration. Interactions among YY1, GA-binding proteins, and mitogenic signals. (1998) (22)
Considerable Differences in Vaccine Immunogenicities and Efficacies Related to the Diluent Used for Aluminum Hydroxide Adjuvant (2008) (22)
Blunting of the immediate-early gene and mitogenic response in hepatectomized type 1 diabetic animals. (1995) (21)
Expression and function of growth-induced genes during liver regeneration (1995) (21)
Molecular cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme. (1994) (20)
Variable amplification of immunoglobulin lambda light-chain genes in human populations. (1983) (20)
A variant translocation places the lambda immunoglobulin genes 3' to the c-myc oncogene in Burkitt's lymphoma. (1984) (19)
Disconnection between the early onset anorectic effects by C75 and hypothalamic fatty acid synthase inhibition in rodents. (2005) (19)
Association of interleukin-1-induced, NF kappa B DNA-binding activity with collagenase gene expression in human gingival fibroblasts. (1996) (19)
Sequence of rat RL/IF-1 encoding an IkappaB, and comparison with related proteins containing notch-like repeats [corrected]. (1992) (18)
Hepatic Fat Reduction Due to Resmetirom in Patients with Nonalcoholic Steatohepatitis Is Associated With Improvement of Quality of Life. (2021) (17)
Rapid activation of latent transcription factor complexes reflects initiating signals in liver regeneration. (1996) (17)
Increased expression of cytokine-induced neutrophil chemoattractant in septic rat liver (1996) (17)
Glucokinase activation – a strategy for T2D therapy: recent developments (2007) (15)
Liver‐specific and proliferation‐induced deoxyribonuclease I hypersensitive sites in the mouse insulin‐like growth factor binding protein‐1 gene (1999) (15)
Discovery and optimization of 2-phenyloxazole derivatives as diacylglycerol acyltransferase-1 inhibitors. (2011) (13)
Synthesis, structure-activity relationships, and in vivo properties of 3,4-dihydro-1H-pyrido[2,3-b]pyrazin-2-ones as corticotropin-releasing factor-1 receptor antagonists. (2004) (13)
Blocking NF-kappaB in the liver: the good and bad news. (1998) (12)
Protein tyrosine phosphatase of liver regeneration-1 is required for normal timing of cell cycle progression during liver regeneration. (2015) (11)
Expression analysis and chromosomal assignment of the human SFRS5/SRp40 gene. (1997) (10)
Expression of the protein tyrosine phosphatase, phosphatase of regenerating liver 1, in the outer segments of primate cone photoreceptors. (2000) (9)
Potent, selective MCH-1 receptor antagonists. (2008) (9)
Variable gene expression within human tyrosinemia type 1 liver may reflect region‐specific dysplasia (1996) (9)
Alternative splicing and structure of the human and mouse SFRS5/HRS/SRp40 genes. (1997) (8)
Sequence of rat RL/IF-1 encoding IKBβ-like activity and comparison with related proteins containing notch-like repeats (1992) (7)
Anxiolytic-Like Effects of the Corticotropin-Releasing Factor 1 ( CRF 1 ) Antagonist DMP 904 [ 4-( 3-pentylamino )-2 , 7-dimethyl-8-( 2-methyl-4-methoxyphenyl )-pyrazolo-[ 1 , 5-a ]-pyrimidine ] Administered Acutely or Chronically at Doses Occupying Central CRF 1 Receptors in Rats (2004) (7)
The effect of translocations on the cellular myc gene in burkitt lymphomas (1984) (7)
Four RFLPs of the human insulin receptor gene: PstI, KpnI, RsaI (2 RFLPs). (1988) (7)
Receptor Occupancy of Non-Peptide CRF 1 Antagonist DMP 696 : Correlation with Drug Exposure and Anxiolytic Efficacy (2002) (4)
Transcriptional Up-regulation of the Delayed Early GeneHRS/SRp40 during Liver Regeneration (1998) (3)
Abstract 5458: VIA-3196, a Liver-directed Thyroid Beta Agonist for Treating Cardiometabolic Disease (2009) (3)
Fatty acid modulators for the treatment of diabesity (2007) (3)
F1-7 Transcriptional control of liver regeneration (1995) (3)
SAT-347-MRI-PDFF response in MGL-3196 and placebo treated patients predicts reduction in ballooning and inflammation components of NAS and NASH resolution in a 36-week serial liver biopsy study (2019) (2)
Discovery of camphor-derived pyrazolones as 11β-hydroxysteroid dehydrogenase type 1 inhibitors. (2014) (2)
Resmetirom (MGL-3196) in Patients With Heterozygous Familial Hypercholesterolemia. (2022) (2)
Anxiolytic-like Effects of the CRF1 Antagonist DMP904 Administered Acutely or Chronically at Doses Occupying Central CRF1 Receptors in Rats (2003) (2)
Adenovirus-mediated overexpression of activin beta(C) subunit accelerates liver regeneration in partially hepatectomized rats. (2005) (2)
GLUCOCORTICOIDS INHIBIT PROGRESSION OF CELL CYCLE PATHWAYS FOLLOWING ISCHEMIA/ REPERFUSION(I/R)INJURY IN THE LIVER.: Abstract# 63 (2000) (2)
Four RFLPs of the human insulin receptor gene: PstI, KpnI, RsaI (2 RFLPs). (1988) (1)
In Orvieto: new insights into liver biology and disease therapy (1999) (1)
P5387LDL cholesterol, apolipoprotein B, lipoprotein(a), apolipoprotein CIII and triglyceride lowering by MGL-3196, a thyroid hormone beta selective agonist, in a 12 week study in HeFH patients (2018) (1)
Biomarkers, imaging and safety in a well-compensated NASH cirrhotic cohort treated with resmetirom, a thyroid hormone receptor beta agonist, for 52 weeks (2022) (1)
CCAAT enhancer binding protein B is required for Fas-induced apoptosis in liver (2000) (1)
IL-6/gpl30/Stat3 (2005) (1)
Sepsis-induced depression of rat glucose-6-phosphatase gene expression and activity. (1997) (1)
Utility of FIB-4 thresholds to identify patients with at-risk F2-F3 NASH based on screening data from a 2000 patient biopsy confirmed cohort of resmetirom Phase 3 clinical trial, MAESTRO-NASH (2022) (0)
INDUCTION OF THE TRANSCRIPTION FACTOR, NF‐&kgr;B, BY CECAL LIGATION AND PUNCTURE (CLP).: 218 (1995) (0)
Impact of resmetirom-mediated reductions in liver volume and steatosis compared with placebo on the quantification of fibrosis using second harmonic generation in a serial liver biopsy study (2022) (0)
Reply to Deleuze and Hadchouel (1996) (0)
Kinase Regulation Kinase / Extracellular Signal-Regulated Mitogen-Activated Protein and β Mice with Defects in C / EBP Growth Factor Binding Protein 1-Deficient Response Posthepatectomy in Insulin-Like Impaired Hepatocyte DNA Synthetic (2002) (0)
SEPSIS INDUCES THE EXPRESSION OF THE CHEMOKINE, CINC, IN RAT HEPATOCYTES (1995) (0)
Roles of Cytokines and Growth Factors in Liver Regeneration, Repair, and Fibrosis after Liver Injury (2002) (0)
Promoter-specific Â¿raws-Activationand Inhibition Mediated by .limit (2006) (0)
78; gro/KC, and MCP‐1/JE, INFLAMMATORY CHEMOKINES, ARE EXPRESSED BY HEPATOCYTES, and INCREASED IN SEPSIS (1994) (0)
Abstracts of papers presented at the 1997 Meeting on Regulation of Liver Gene Expression in Health & Disease, April 30-May 4, 1997 (1997) (0)
Single-strand conformational polymorphism analysis of human GLUT5 in isolated fructose malabsorption (1995) (0)
In Orvieto: new insights into liver biopsy and disease therapy. 8th Biennial International Congress on Liver Development, Gene Regulation and Disease. Orvieto, Italy, 2-5 June 1999. (1999) (0)
Alagille Syndrome: Cytogenetic and Molecular Studies (2007) (0)
INITIATION OF EARLY SIGNAL TRANSDUCTION PATHWAYS IN THE LIVER FOLLOWING COLD ISCHEMIA AND REPERFUSION INJURY (1999) (0)
The Non-Alcoholic Steatohepatitis and Cardiovascular Disease Intersection, an Important Consideration in Drug Development (2020) (0)
Retrospective AI-based measurement of NASH histology (AIM-NASH) analysis of biopsies from Phase 2 study of Resmetirom confirms significant treatment-induced changes in histologic features of non-alcoholic steatohepatitis (2022) (0)
INDUCTION OF THE TRANSCRIPTION FACTOR, NFKB, BY CECAL LIGATION, and PUNCTURE (CLP) (1995) (0)
Buspirone is a Major Active Metabolite of Buspirone : Assessment of Pharmacokinetics and 5-HT 1 A Receptor Occupancy in Rats (2007) (0)
Translocation of the c-mnc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells ( recombination / chromosome / cancer / DNA ) (0)
INITIATION OF SIGNAL TRANSDUCER AND ACTIVATORS OF TRANSCRIPTION (STATs) FOLLOWING ISCHEMIA/REPERFUSION INJURY (1998) (0)
Treatment with interleukin-6 reduces liver damage and apoptotic hepatocyte death and enhances recovery in acute toxic injury (1998) (0)
Abstract 11958: Pharmacokinetics, Safety and Cholesterol Lowering in Healthy Volunteers Treated with Single and Multiple Doses of Madrigal's 3196 Liver-directed Thyroid Hormone Receptor- Agonist (2012) (0)
Translocation ofthec-mncgeneintotheimmunoglobulin heavy chain locus inhumanBurkitt lymphoma andmurine plasmacytoma cells (1982) (0)
The Structure and Function of the Normal c-myc Gene and Its Alteration in Malignant Cells (1987) (0)

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What Schools Are Affiliated With Rebecca A. Taub?

Rebecca A. Taub is affiliated with the following schools:

University of Pennsylvania