Reginald F. Frye
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Computer Science
Reginald F. Frye's Degrees
- PhD Computer Science Stanford University
- Masters Computer Science University of California, Berkeley
- Bachelors Computer Science University of California, Berkeley
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(Suggest an Edit or Addition)Reginald F. Frye's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- DHEA and DHEA‐S: A Review (1999) (527)
- Validation of the five‐drug “Pittsburgh cocktail” approach for assessment of selective regulation of drug‐metabolizing enzymes (1997) (241)
- Effect of St John's Wort on imatinib mesylate pharmacokinetics (2004) (230)
- Liver disease selectively modulates cytochrome P450–mediated metabolism (2006) (204)
- Induction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures. (2004) (181)
- Bioequivalence revisited: Influence of age and sex on CYP enzymes (2004) (151)
- Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure (2003) (144)
- Effects of high-fructose corn syrup and sucrose on the pharmacokinetics of fructose and acute metabolic and hemodynamic responses in healthy subjects. (2012) (140)
- Plasma levels of TNF-alpha and IL-6 are inversely related to cytochrome P450-dependent drug metabolism in patients with congestive heart failure. (2002) (137)
- ESRD impairs nonrenal clearance of fexofenadine but not midazolam. (2009) (122)
- Hepatic drug metabolism and transport in patients with kidney disease. (2003) (109)
- In vivo modulation of CYP enzymes by quinidine and rifampin (2000) (101)
- Effects of herbal supplements on drug glucuronidation. Review of clinical, animal, and in vitro studies. (2011) (98)
- Tolbutamide, Flurbiprofen, and Losartan as Probes of CYP2C9 Activity in Humans (2003) (95)
- Drug Administration in Patients with Renal Insufficiency (1997) (94)
- Determinants of vancomycin clearance by continuous venovenous hemofiltration and continuous venovenous hemodialysis. (1998) (93)
- Application of semisimultaneous midazolam administration for hepatic and intestinal cytochrome P450 3A phenotyping (2002) (90)
- Pharmacokinetics of α-mangostin in rats after intravenous and oral application. (2011) (76)
- Probing the world of cytochrome P450 enzymes. (2004) (74)
- Pharmacometabolomics Reveals Racial Differences in Response to Atenolol Treatment (2013) (70)
- Differences in flurbiprofen pharmacokinetics between CYP2C9*1/*1, *1/*2, and *1/*3 genotypes (2003) (70)
- Chloroquine modulation of specific metabolizing enzymes activities: investigation with selective five drug cocktail. (1998) (68)
- Determination of chlorzoxazone and 6-hydroxychlorzoxazone in human plasma and urine by high-performance liquid chromatography. (1996) (66)
- Effect of hepatic impairment on the pharmacokinetics of atomoxetine and its metabolites (2003) (66)
- Evaluation of the Influence of Diabetes Mellitus on Antipyrine Metabolism and CYP1A2 and CYP2D6 Activity (2000) (65)
- A sensitive and specific liquid chromatography-tandem mass spectrometry method for the determination of intracellular and extracellular uric acid. (2009) (60)
- Differential effect of IFNalpha-2b on the cytochrome P450 enzyme system: a potential basis of IFN toxicity and its modulation by other drugs. (2002) (56)
- Simultaneous determination of uric acid metabolites allantoin, 6-aminouracil, and triuret in human urine using liquid chromatography-mass spectrometry. (2009) (54)
- Cefazolin as empiric therapy in hemodialysis-related infections: efficacy and blood concentrations. (1998) (53)
- The effect of trimethoprim on CYP2C8 mediated rosiglitazone metabolism in human liver microsomes and healthy subjects. (2005) (53)
- Pharmacokinetics of Intermittent Intraperitoneal Cefazolin in Continuous Ambulatory Peritoneal Dialysis Patients (1999) (53)
- Pharmacogenomics competencies in pharmacy practice: A blueprint for change. (2017) (51)
- Inhibitory effects of commonly used herbal extracts on UGT1A1 enzyme activity (2010) (50)
- The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney. (2004) (50)
- Effect of chronic disulfiram administration on the activities of CYP1A2, CYP2C19, CYP2D6, CYP2E1, and N-acetyltransferase in healthy human subjects. (2002) (49)
- Early Atorvastatin Reduces Hemorrhage after Acute Cerebral Ischemia in Diabetic Rats (2009) (49)
- Inhibitory Effects of Commonly Used Herbal Extracts on UDP-Glucuronosyltransferase 1A4, 1A6, and 1A9 Enzyme Activities (2011) (48)
- Sensitive liquid chromatographic method using fluorescence detection for the determination of estradiol 3- and 17-glucuronides in rat and human liver microsomal incubations: formation kinetics. (2002) (48)
- Minimal in vivo activation of CYP2C9-mediated flurbiprofen metabolism by dapsone. (2001) (48)
- The Effects of Milk Thistle (Silybum marianum) on Human Cytochrome P450 Activity (2014) (48)
- Validation of incorporating flurbiprofen into the Pittsburgh cocktail (2006) (47)
- Cyclophosphamide and 4-hydroxycyclophosphamide pharmacokinetics in patients with glomerulonephritis secondary to lupus and small vessel vasculitis. (2012) (46)
- Intravenous Vancomycin Pharmacokinetics in Automated Peritoneal Dialysis Patients (2001) (45)
- Simplified method for determination of rosiglitazone in human plasma. (2004) (45)
- Pharmacokinetics of intermittent intravenous cefazolin and tobramycin in patients treated with automated peritoneal dialysis. (2000) (44)
- Pioglitazone improves hepatic mitochondrial function in a mouse model of nonalcoholic steatohepatitis. (2018) (44)
- Determinants of Ceftriaxone Clearance by Continuous Venovenous Hemofiltration and Hemodialysis (2000) (42)
- Interaction of sorafenib and cytochrome P450 isoenzymes in patients with advanced melanoma: a phase I/II pharmacokinetic interaction study (2011) (42)
- High-performance liquid chromatographic assay for acetaminophen glucuronide in human liver microsomes. (2001) (41)
- Cytochrome P-450 activity is differentially altered in severely injured patients (2005) (41)
- Inhibition of Intestinal and Hepatic Glucuronidation of Mycophenolic Acid by Ginkgo biloba Extract and Flavonoids (2010) (41)
- Pharmacokinetics of intermittent intraperitoneal ceftazidime. (1999) (38)
- Influence of DHEA Administration on 24-Hour Cortisol Concentrations (2003) (38)
- Sensitive and specific high-performance liquid chromatographic assay for 4'-hydroxyflurbiprofen and flurbiprofen in human urine and plasma. (2000) (38)
- Determination of famotidine in human plasma and urine by high-performance liquid chromatography. (1999) (37)
- Determinants of Ceftazidime Clearance by Continuous Venovenous Hemofiltration and Continuous Venovenous Hemodialysis (2000) (37)
- Effect of Ceftazidime on Systemic Cytokine Concentrations in Rats (2000) (37)
- Use of Chlorzoxazone as an In Vivo Probe of Cytochrome P450 2E1: Choice of Dose and Phenotypic Trait Measure (1998) (37)
- Pharmacokinetic Properties of Pure Xanthones in Comparison to a Mangosteen Fruit Extract in Rats (2013) (36)
- Evaluation of gentamicin pharmacokinetics and dosing protocols in 195 neonates. (1998) (36)
- Enzyme‐ and transporter‐mediated beverage–drug interactions: An update on fruit juices and green tea (2015) (36)
- Pyrosequencing method for genotyping cytochrome P450 CYP2C8 and CYP2C9 enzymes. (2004) (35)
- A summer research training program to foster PharmD students' interest in research. (2008) (35)
- CYP2D6 mRNA expression in circulating peripheral blood mononuclear cells correlates with in vivo debrisoquine hydroxylase activity in extensive metabolizers. (1996) (34)
- In Vivo Alterations in Drug Metabolism and Transport Pathways in Patients with Chronic Kidney Diseases (2014) (33)
- Cefazolin dialytic clearance by high-efficiency and high-flux hemodialyzers. (2001) (32)
- Cytochrome P450 mRNA expression in peripheral blood lymphocytes as a predictor of enzyme induction (2005) (31)
- Debilitating Reaction following the Initial Dose of Tramadol (1997) (30)
- Effect of Cytochrome P450 3A5 Genotype on Atorvastatin Pharmacokinetics and Its Interaction with Clarithromycin (2011) (29)
- Simplified method for determination of clarithromycin in human plasma using protein precipitation in a 96-well format and liquid chromatography-tandem mass spectrometry. (2008) (27)
- Sex Differences in the Pharmacokinetics of Dehydroepiandrosterone (DHEA) after Single‐ and Multiple‐Dose Administration in Healthy Older Adults (2000) (26)
- Evaluation of flurbiprofen urinary ratios as in vivo indices for CYP2C9 activity. (2007) (26)
- Association of branched and aromatic amino acids levels with metabolic syndrome and impaired fasting glucose in hypertensive patients. (2015) (24)
- Induction of CYP2E1 activity in liver transplant patients as measured by chlorzoxazone 6‐hydroxylation (1998) (24)
- Effect of valerian, valerian/hops extracts, and valerenic acid on glucuronidation in vitro (2007) (24)
- Vancomycin Disposition following Intraperitoneal Administration in Children Receiving Peritoneal Dialysis (2007) (23)
- Simultaneous determination of p-aminohippuric acid, acetyl-p-aminohippuric acid and iothalamate in human plasma and urine by high-performance liquid chromatography. (1998) (23)
- Pharmacokinetics of Intraperitoneal Cefepime in Automated Peritoneal Dialysis (2005) (23)
- Is a Diabetes Mellitus–Linked Amino Acid Signature Associated With &bgr;-Blocker–Induced Impaired Fasting Glucose? (2014) (23)
- A Genetic Response Score for Hydrochlorothiazide Use: Insights From Genomics and Metabolomics Integration. (2016) (22)
- Intermittent Intravenous Piperacillin Pharmacokinetics in Automated Peritoneal Dialysis Patients (2000) (22)
- Improved high-performance liquid chromatographic determination of debrisoquine and 4-hydroxydebrisoquine in human urine following direct injection. (1996) (22)
- Coordinated intrahepatic and extrahepatic regulation of cytochrome P4502D6 in healthy subjects and in patients after liver transplantation (2003) (22)
- Current clinical evidence on pioglitazone pharmacogenomics (2013) (22)
- Comparison of Iothalamate Clearance Methods for Measuring GFR (1999) (21)
- Effect of Nortriptyline and Paroxetine on CYP2D6 Activity in Depressed Elderly Patients (2002) (21)
- Characterization of tubular functional capacity in humans using para-aminohippurate and famotidine. (2001) (21)
- Pharmacokinetics and tissue distribution of dodeca-2E,4E,8E,10E/Z-tetraenoic acid isobutylamides after oral administration in rats. (2009) (20)
- Effect of Conjugated Equine Estrogens on Oxidative Metabolism in Middle‐aged and Elderly Postmenopausal Women (2006) (20)
- A Genetic Score Associates With Pioglitazone Response in Patients With Non-alcoholic Steatohepatitis (2018) (20)
- Teicoplanin Nephrotoxicity: First Case Report (1992) (20)
- Plasma Coenzyme Q10 Predicts Lipid-lowering Response to High-Dose Atorvastatin. (2008) (19)
- Sphingolipid Metabolic Pathway Impacts Thiazide Diuretics Blood Pressure Response: Insights From Genomics, Metabolomics, and Lipidomics (2017) (19)
- The effect of milk thistle (Silybum marianum) and its main flavonolignans on CYP2C8 enzyme activity in human liver microsomes. (2017) (18)
- Determination of 20-hydroxyeicosatetraenoic acid in microsomal incubates using high-performance liquid chromatography-mass spectrometry (HPLC-MS). (2003) (18)
- Effect of St. John's Wort on imatinib mesylate pharmacokinetics (2004) (18)
- A sensitive method for the simultaneous determination of caffeine and its dimethylxanthine metabolites in human plasma : Application to CYP1A2 phenotyping (1998) (17)
- Effects of liver disease on the disposition of the opioid antagonist nalmefene (1997) (17)
- Concentration‐dependent response to pioglitazone in nonalcoholic steatohepatitis (2017) (17)
- Use of Enantiomeric Bupropion and Hydroxybupropion to Assess CYP2B6 Activity in Glomerular Kidney Diseases (2010) (16)
- Early thrombin formation capacity in trauma patients and association with venous thromboembolism. (2016) (16)
- The Effect of Renal Insufficiency and Hemodialysis on the Pharmacokinetics of Nalmefene (1996) (16)
- Effect of Age and Postoperative Time on Cytochrome P450 Enzyme Activity Following Liver Transplantation (2005) (16)
- Presence of arachidonoyl-carnitine is associated with adverse cardiometabolic responses in hypertensive patients treated with atenolol (2016) (15)
- Pharmacokinetics of valerenic acid in rats after intravenous and oral administrations. (2012) (15)
- A validated liquid chromatography tandem mass spectrometry method for simultaneous determination of pioglitazone, hydroxypioglitazone, and ketopioglitazone in human plasma and its application to a clinical study. (2014) (14)
- Determination of N-desethylamodiaquine by hydrophilic interaction liquid chromatography with tandem mass spectrometry: application to in vitro drug metabolism studies. (2008) (14)
- Determination of mycophenolic acid glucuronide in microsomal incubations using high performance liquid chromatography-tandem mass spectrometry. (2008) (14)
- Sensitive high-performance liquid chromatographic determination of chlorzoxazone and 6-hydroxychlorzoxazone in plasma. (1993) (13)
- Relative Bioavailability of Silybin A and Silybin B From 2 Multiconstituent Dietary Supplement Formulations Containing Milk Thistle Extract: A Single-dose Study. (2018) (12)
- Validation and application of a liquid chromatography-tandem mass spectrometric method for quantification of the drug transport probe fexofenadine in human plasma using 96-well filter plates. (2010) (12)
- The Role of Pharmacogenetics in the Treatment of Chronic Hepatitis C Infection (2014) (12)
- The effect of age on the pharmacokinetics of the opioid antagonist nalmefene. (2003) (11)
- Stereoselective determination of the CYP2C19 probe drug mephenytoin in human urine by gas chromatography-mass spectrometry. (2003) (11)
- Determination of trimethoprim in low-volume human plasma by liquid chromatography. (2004) (10)
- Novel plasma biomarker of atenolol-induced hyperglycemia identified through a metabolomics-genomics integrative approach (2016) (10)
- Impaired 6‐hydroxychlorzoxazone elimination in patients with kidney disease: Implication for cytochrome P450 2E1 pharmacogenetic studies (2003) (10)
- Toxicological and Pharmacokinetic Evaluation of Concomitant Intake of Grapefruit Juice and Simvastatin in Rats after Repeated Treatment over 28 Days. (2009) (10)
- Examination of Metoprolol Pharmacokinetics and Pharmacodynamics Across CYP2D6 Genotype‐Derived Activity Scores (2020) (10)
- Effect of pterostilbene on in vitro drug metabolizing enzyme activity (2019) (10)
- Inhibitory effect of six herbal extracts on CYP2C8 enzyme activity in human liver microsomes (2015) (10)
- Absolute/relative bioavailability and metabolism of dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamides (tetraenes) after intravenous and oral single doses to rats. (2011) (9)
- Interpopulation variation frequency of human inosine 5'-monophosphate dehydrogenase type II (IMPDH2) genetic polymorphisms. (2008) (9)
- Stability of Cefepime in Icodextrin Peritoneal Dialysis Solution (2004) (9)
- Effect of renal insufficiency on CYP activity (1996) (9)
- Atenolol Exposure and Risk for Development of Adverse Metabolic Effects: A Pilot Study (2010) (9)
- Rapid microtiter plate assay for determination of inulin in human plasma and dialysate. (2002) (9)
- Effect of CYP2C8 genotype on rosiglitazone pharmacokinetics (2005) (9)
- Metabolomic association between venous thromboembolism in critically ill trauma patients and kynurenine pathway of tryptophan metabolism. (2018) (8)
- Pharmacokinetics of Intraperitoneal Cefazolin and Ceftazidime Coadministered to CAPD Patients (2005) (8)
- A Preliminary Study on the Effects of Self-Reported Dietary Caffeine on Pain Experience and Postoperative Analgesia. (2012) (8)
- Estimation of the hepatic extraction ratio of indocyanine green in swine. (1993) (8)
- Intensive Care Unit Delirium in Surgical Patients Is Associated with Upregulation in Tryptophan Metabolism (2020) (7)
- Effect of Disulfiram‐Mediated CYP2E1 Inhibition on the Disposition of Vesnarinone (1999) (7)
- Determination of visnagin in rat plasma by liquid chromatography with tandem mass spectrometry and its application to in vivo pharmacokinetic studies. (2009) (6)
- Identification of omega hydroxy fatty acids in biological samples as their pentafluoropropyl derivatives by gas chromatography/mass spectrometry with positive and negative ion detection. (2002) (6)
- Nicotine as a factor in stress responsiveness among detoxified alcoholics. (2011) (6)
- Effect of the acute phase response induced by endotoxin administration on the expression and activity of UGT isoforms in rats. (2008) (6)
- Stability of Atropine Sulfate Prepared for Mass Chemical Terrorism (2003) (5)
- Pharmacokinetics of abecarnil in patients with renal insufficiency (1996) (4)
- Effect of St. John's Wort administration on CYP2C8 mediated rosiglitazone metabolism (2005) (4)
- Nalmefene to Prevent Epidural Narcotic Side Effects in Pediatric Patients: A Pharmacokinetic and Safety Study (2000) (4)
- Inhibitory Effects of Commonly Used Herbal Extracts on UGT 1 A 4 , 1 A 6 , and 1 A 9 Enzyme Activities (2011) (3)
- The influence of type i and type ii diabetes mellitus on antipyrine disposition (1992) (3)
- Effect of Low‐Furanocoumarin Hybrid Grapefruit Juice Consumption on Midazolam Pharmacokinetics (2017) (2)
- Cytochrome P450 Function in Pediatric Sepsis-Induced Multiple Organ Failure.♦ 179 (1997) (2)
- Impared 6‐hydroxychlorzoxazone elimination in patients with renal insufficiency: Implication for pharmacogenetic studies (1996) (2)
- Diminished Oxidative Metabolizing Capacity of Specific Cytochrome P450 (P450) Isozymes in Sepsis Induced Pediatric Multiple Organ Failure (MOF) (1998) (2)
- A Genetic Response Score for Hydrochlorothiazide UseNovelty and Significance (2016) (2)
- Abstract 11088: Pharmacometabolomics Reveals a Novel Signature for Predicting Beta Blocker Associated Impaired Fasting Glucose (2012) (1)
- Tick-Tock...genes working round the clock: associations with sleep and acute and chronic post-thoracotomy pain (2013) (1)
- Pharmacokinetics of chlorzoxazone An in vivo probe of cytochrome P4502E1 activity (1993) (1)
- Integrating Metabolomics And Genomics Reveals Novel Biomarkers Of Hydrochlorothiazide Response In Pharmacogenomic Evaluation Of Antihypertensive Responses (pear) Study: Qp-04 (2015) (1)
- THE EFFECT OF ISONIAZID ON CYP 2 E 1-AND CYP 4 A-MEDIATED HYDROXYLATION OF ARACHIDONIC ACID IN THE RAT LIVER AND KIDNEY (2004) (1)
- (155) Can thoracotomy patients be “immune” to developing chronic pain? Examination of the role of immune and inflammatory markers in the post-surgical trajectory (2015) (1)
- Absolute and relative bioavailabilities of dodeca-2E, 4E, 8E, 10E/Z-tetraenoic acid isobutylamides after intravenous and oral single doses in rats (2009) (1)
- 2235: Equipping health professional students to apply pharmacogenomic data to clinical decision making in real-world scenarios: Comparison of an active engagement Versus didactic teaching approach (2017) (1)
- Pharmacodynamic modeling of erythropoietin therapy (1992) (1)
- Selective Modulation of Cyp‐Mediated Metabolism in Liver Disease (2003) (1)
- Effect of conjugated estrogen replacement therapy (ERT) on CYP activity (1997) (1)
- Application of a map Bayesian method for CYP2E1 phenotyping (2004) (1)
- CONTINUOUS VENOVENOUS HEMODIALYSIS (CVVHD) CLEARANCE OF CEFTRIAXONE (1996) (1)
- Evaluating an interactive teaching approach with personal genotyping to provide pharmacy students with a knowledge base for clinical pharmacogenetics (2020) (1)
- Abstract 18338: Genomics-metabolomics Integrative Approach Reveals Novel Biomarkers In DPYS Associated With Higher Glucose Change After Treatment With Atenolol (2015) (0)
- Differential response of serum iron indices (SII) to iron dextran (ID) in hemodialysis patients (1996) (0)
- Abstracts for poster presentationB. System (physiology, anatomy, animal models): B30 - other(680): Ethnic differences in acute pain and analgesic side effects (2007) (0)
- RESEARCH Mitochondria Dysfunction in Aging and Metabolic Diseases Pioglitazone improves hepatic mitochondrial function in a mouse model of nonalcoholic steatohepatitis (2018) (0)
- Abstract 13621: Integrating Metabolomics and Genomics Uncovers Novel Pathways and Genetic Signatures Influencing Hydrochlorothiazide Blood Pressure Response: A Genetic Response Score for Hydrochlorothiazide Use (2015) (0)
- Bioavailability of dodeca-2E,4E,8E,10E/Z-tetraenoic acid isobutylamides after oral administration in rats and distribution in various tissues (2009) (0)
- Population Pharmacokinetic Model of Chlorzoxazone and 6‐Hydroxychlorzoxazone in Renal Failure: Impact of Patient Covariates on CYP2E1 Activity (2003) (0)
- A model for predicting chronic post-thoracotomy pain among patients with lung cancer (2011) (0)
- Pharmacokinetic profiling of dodeca-2E,4E,8E,10E/Z-tetraenoic acid isobutylamides in rats using liquid chromatography tandem mass spectrometry (2008) (0)
- Book Review: Infectious Diseases: Prophylaxis & Chemotherapy (1991) (0)
- DMD057232 1611..1616 (2014) (0)
- Predicting the vagaries and vestiges of post-thoracotomy pain (2012) (0)
- Associations of pre-operative experimental pain and psychosocial measures with acute post-operative pain and side effects (2009) (0)
- A randomized, cross‐over trial of metoprolol succinate formulations to evaluate PK and PD end points for therapeutic equivalence (2022) (0)
- PII‐37 (2006) (0)
- Identifying risk factors for acute post-operative pain from oral surgery in an ethnically diverse sample (2011) (0)
- (398) Evidence for response differences in acute post-operative pain and side effects in a multi-ethnic sample (2008) (0)
- Presence of arachidonoyl-carnitine is associated with adverse cardiometabolic responses in hypertensive patients treated with atenolol (2016) (0)
- 2235 (2017) (0)
- Examination of predictive models for surgical outcome and change over time (2010) (0)
- DRUG METABOLISM IN OLDER OLTx PATIENTS: EFFECTS OF DONOR AND RECIPIENT AGE. (1999) (0)
- 1179: EARLY HYPERCOAGULABILITY IN TRAUMA ICU PATIENTS DETECTED BY CALIBRATED AUTOMATED THROMBOGRAM (2015) (0)
- Novel plasma biomarker of atenolol-induced hyperglycemia identified through a metabolomics-genomics integrative approach (2016) (0)
- Absolute Bioavailability and Metabolism of Dodeca-2E,4E,8E,10E/Z-tetraenoic acid isobutylamides (“tetraene”) after Intravenous and Oral Single Doses to Rats (2009) (0)
- The pharmacokinetic properties of pure γ-mangostin in rats in comparison to mangosteen extract (2012) (0)
- Bioavailability of dodeca-2E, 4E, 8E, 10E/Z-tetraenoic acid isobutylamides after oral administration in rats and distribution in various tissues (2009) (0)
- Changes in CYP450 enzyme activity over time following liver transplantation (2005) (0)
- Students' experience in a phase III clinical trial. (1990) (0)
- DRUG METABOLISM IN PEDIATRIC LIVER TRANSPLANTATION 199 (1997) (0)
- The Influence of Cannabidiol on the Pharmacokinetics of Methylphenidate in Healthy Subjects (2022) (0)
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